Dr Allan Young

Senior Lecturer
Surgery, Northern Clinical School


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Selected publications

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Journals

  • Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012). Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine, 37(1), 18-25. [More Information]
  • Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gilles, R., Dart, A., Sonnabend, D., Little, C. (2008). Modulation of Aggrecan and ADAMTS Expression in Ovine Tendinopathy Induced by Altered Strain. Seminars in Arthritis and Rheumatism, 58(4), 1055-1066. [More Information]
  • Cake, M., Smith, M., Young, A., Smith, S., Ghosh, P., Read, R. (2008). Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan). Clinical and Experimental Rheumatology, 26(4), 561-567. [More Information]
  • Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2007). Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. European Spine Journal, 16(12), 2193-2205. [More Information]
  • Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. (2007). Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical Orthopaedics and Related Research, 462, 212-220. [More Information]
  • Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research & Therapy, 8(2), 1-6. [More Information]
  • Young, A., Stanwell, P., Williams, A., Rohrsheim, J., Parker, D., Giuffre, B., Ellis, A. (2005). Glycosaminoglycan content of knee cartilage following posterior cruciate ligament rupture demonstrated by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). A case report. Journal of Bone and Joint Surgery-American Volume, 87(12), 2763-2767. [More Information]
  • Young, A., Smith, M., Smith, S., Burkhardt, D., Cake, M., Melrose, J., Read, R., Ghosh, P., Sonnabend, D., Little, C. (2005). Metabolism of Small Leucine-Rich Proteoglycans in an Ovine Model of Osteoarthritis. 51st Annual Meeting of the Orthopaedic Research Society, 30, 1057-1057.
  • Young, A., Smith, M., Smith, S., Cake, M., Ghosh, P., Read, R., Melrose, J., Sonnabend, D., Roughley, P., Little, C. (2005). Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Research & Therapy, 7(4), R852-61. [More Information]

Conferences

  • Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2008). Spatial and temporal catabolism of the small leucine repeat proteoglycans (SLRPs) in an ovine annular lesion model of experimental intervertebral disc degeneration has structure-function implications. World Forum for Spine Research 2008, Switzerland: AO Foundation.
  • Smith, M., Sakurai, A., Smith, S., Young, A., Melrose, J., Dart, A., Sonnabend, D., Little, C. (2006). Altered aggrecan and ADAMTS expression in overload-induced tendon pathology. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Young, A., McLennan, S., Smith, S., Smith, M., Melrose, J., Cake, M., Flannery, C., Sonnabend, D., Little, C. (2006). Changes in expression and immunolcalization of proteoglycan 4 / lubricin in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Young, A., Smith, S., Jackson, M., Smith, M., Burkhardt, D., Appleyard, R., Cake, M., Read, R. (2006). Regional changes in expression and activity of ADAMTS and MMP enzymes in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.

2012

  • Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012). Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine, 37(1), 18-25. [More Information]

2008

  • Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gilles, R., Dart, A., Sonnabend, D., Little, C. (2008). Modulation of Aggrecan and ADAMTS Expression in Ovine Tendinopathy Induced by Altered Strain. Seminars in Arthritis and Rheumatism, 58(4), 1055-1066. [More Information]
  • Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2008). Spatial and temporal catabolism of the small leucine repeat proteoglycans (SLRPs) in an ovine annular lesion model of experimental intervertebral disc degeneration has structure-function implications. World Forum for Spine Research 2008, Switzerland: AO Foundation.
  • Cake, M., Smith, M., Young, A., Smith, S., Ghosh, P., Read, R. (2008). Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan). Clinical and Experimental Rheumatology, 26(4), 561-567. [More Information]

2007

  • Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2007). Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. European Spine Journal, 16(12), 2193-2205. [More Information]
  • Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. (2007). Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical Orthopaedics and Related Research, 462, 212-220. [More Information]

2006

  • Smith, M., Sakurai, A., Smith, S., Young, A., Melrose, J., Dart, A., Sonnabend, D., Little, C. (2006). Altered aggrecan and ADAMTS expression in overload-induced tendon pathology. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Young, A., McLennan, S., Smith, S., Smith, M., Melrose, J., Cake, M., Flannery, C., Sonnabend, D., Little, C. (2006). Changes in expression and immunolcalization of proteoglycan 4 / lubricin in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research & Therapy, 8(2), 1-6. [More Information]
  • Young, A., Smith, S., Jackson, M., Smith, M., Burkhardt, D., Appleyard, R., Cake, M., Read, R. (2006). Regional changes in expression and activity of ADAMTS and MMP enzymes in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.

2005

  • Young, A., Stanwell, P., Williams, A., Rohrsheim, J., Parker, D., Giuffre, B., Ellis, A. (2005). Glycosaminoglycan content of knee cartilage following posterior cruciate ligament rupture demonstrated by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). A case report. Journal of Bone and Joint Surgery-American Volume, 87(12), 2763-2767. [More Information]
  • Young, A., Smith, M., Smith, S., Burkhardt, D., Cake, M., Melrose, J., Read, R., Ghosh, P., Sonnabend, D., Little, C. (2005). Metabolism of Small Leucine-Rich Proteoglycans in an Ovine Model of Osteoarthritis. 51st Annual Meeting of the Orthopaedic Research Society, 30, 1057-1057.
  • Young, A., Smith, M., Smith, S., Cake, M., Ghosh, P., Read, R., Melrose, J., Sonnabend, D., Roughley, P., Little, C. (2005). Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Research & Therapy, 7(4), R852-61. [More Information]

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