Associate Professor Anandwardhan Hardikar

Associate Professor and Australian Future Fellow (ARC)
NHMRC Clinical Trials Centre, Sydney Medical School

Telephone +61 2 9562 5000
Fax +61 2 9565 1863

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Biographical details

Anandwardhan A. Hardikar, PhD, received MSc in Zoology (Genetics) and a PhD in Zoology from the University of Pune. After successful completion of his PhD work, carried out mainly at the National Center for Cell Science and partly at the WHO center, Catholic University of Louvain, Louvain-La-Neuve, Belgium, he continued training in the field of pancreas biology and diabetes at the University of Pennsylvania, School of Medicine, where he worked with Doris Stoffers. He worked with Professor Bernie Tuch at the University of New South Wales/POWH during the year 2000, where he pursued his research interests in transplantation of insulin-producing surrogate beta-cells. After his research tenure (2001-2005) in the laboratory of Marvin Gershengorn, Scientific Director, NIDDK, NIH, Bethesda, MD, he went on to join the National Center for Cell Science, Pune, India. Associate Professor Hardikar lead Diabetes and Pancreas Biology Section at O'Brien Institute, St. Vincent's Hospital and the University of Melbourne, in Melbourne, Australia.

Research interests

Our research is focused on understanding islet cell biology, specifically related to development, differentiation and death of human pancreatic beta cells. We work with cadaveric human pancreatic islets as well as biliary duct and gallbladder-derived cells to gather information that would help us understand development of insulin-producing cells. Our previous studies using next generation sequencing of developing human pancreas using the SOLiD platform have provided insight to understanding the role of ncRNAs (specifically microRNAs) in development and differentiation of insulin-producing cells. Present research projects involve applying this information to differentiation of human pancreatic progenitor cells. In addition to these studies, other projects in the lab are focused on understanding the epigenetic modifications in insulin-producing cells in a unique model of multigeneration undernutrition. These studies involve understanding the influence of diet, micronutrients, intrautetine programming and gut microbiota in development of central adiposity, insulin resistance and type 2 diabetes.

CURRENT FUNDED PROJECTS:
1) Australian Future Fellowship: The RAPID Study: RNA-based Analysis for Prediction of Islet Death Study group: http://www.RAPIDstudy.info/ Funding Agency: Australian Research Council (ARC)- Future Fellowship (Level 2) Period of Funding: 2011 - 2015 (mostly salary support)
Total Funding: A$ 816,756

2)A Novel Method to Diagnose Damage to the Eye in Individuals with Diabetes
Funding agency: Rebecca L Cooper Foundation (Equipment grant)
Period of funding: 2013
Total Funding: A$ 18,000

3) Generating New Pancreas from Old
Funding agency: Diabetes Australia Research Trust
Period of Funding: 2012 – 2013
Total Funding: A$ 59,148

4) FIELD LIFE Study: Unlocking gene - environment interactions in Type 2 diabetes andits complications
Study group: FIELD LIFE: Lifestyle Interactions in Fenofibrate and the Epigenome
Funding Agency: National Health and Medical Research Council (NHMRC)
Period of Funding: 2013 –2015
Total Funding: A$ 1,071,753

5) Development and Characterization of Gallbladder Epithelial Cells (Sole Chief Investigator)
Funding Agency: National Health and Medical Research Council (NHMRC)
Period of Funding: May 2012 – April 2015
Total Funding: A$ 650,875

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • A clinical study for validating beta cell death in type 1 diabetes; Hardikar A; Juvenile Diabetes Research Foundation (Australia)/Pilot and Feasibility Grants.
  • Identifying molecular mechanisms regulating the expression of endocrine pancreatic microRNAs following exposure to metabolic effectors; Hardikar A, Walker M; Weizmann Institute of Science/Weizmann Australia Making Connections Grant.
  • A high-throughput, bright-field and fluorescence digital slide scanning platform and service that is both research and teaching-focused and available University-wide.; King N, Graeber M, Naylor M, Slapeta J, Quinnell R, Charles (nee Slaviero) K, Owens T, Bourne R, Braet F, Hambly B, Overall R, Stone J, Twigg S, Hardikar A, Halliday G, Richardson D, Byrne M, Keay K, Marsh D, Howell V, Pollock C, Chen X; DVC Research/Equipment Grant.
  • FIELD LIFE Study: Unlocking gene - environment interactions in Type 2 diabetes and its complications; Keech A, Hardikar A, Jenkins A, Blankenberg S, Best J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Generating new pancreas from old; Hardikar A; Diabetes Australia Research Trust/Research Grants.
  • A novel method to diagnose damage to eye in diabetes; Hardikar A; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2012

  • RNA-based analysis for prediction of islet death in diabetes; Hardikar A; Australian Research Council (ARC)/Future Fellowships (FT).
  • Gallbladder Epithelial Cells for treatment of Diabetes; Hardikar A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Development and Characterization of Gallbladder Epithelial Cells; Hardikar A; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • ACU-OBI Center of Excellence on Diabetes, vascular biology and tissue engineering; Hardikar A; Australian Catholic University/Research Grant.
  • Gallbladder-derived islet progenitor cells for treatment of diabetes; Hardikar A, Thiruchelvam D, Williams R; St Vincent's Hospital Melbourne/Research Endowment Fund.
  • Characterization of adult islet progenitor cells; Hardikar A; Helen Macpherson Smith Trust/Research Grant.

2009

  • Establishing Diabetes Group; Hardikar A; O'Brien Foundation/Barbara Walker Fellowship.

2008

  • Functional Assessment of Pancreatic Islets Following Transplantation using immunoisolatory devices; Hardikar A; Government of lndia - Department of Biotechnology /Research Grant.

Selected publications

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Book Chapters

  • Joglekar, M., Hardikar, A. (2013). Human Pancreatic Progenitors: Implications for Clinical Transplantation in Diabetes. In Niranjan Bhattacharya, Phillip Stubblefield (Eds.), Human Fetal Tissue Transplantation, (pp. 237-249). London: Springer.
  • Joglekar, M., Hardikar, A. (2012). Isolation, Expansion, and Characterization of Human Islet-Derived Progenitor Cells. In Shree Ram Singh (Eds.), Methods in Molecular Biology: Somatic Stem Cells, (pp. 351-366). New York, United States: Humana Press.
  • Lie, K., Chayosumrit, M., Hardikar, A., Sidhu, K. (2012). Puluripotent stem cells and diabetes: Basic Science to Clinical Applications. In Sidhu, K. S. (Eds.), Frontiers in pluripotent stem cells research: Bench-to-Bedside, (pp. 143-167). Dubai, ARE: Bentham Science Publishers.
  • Joglekar, M., Hardikar, A., Sahu, S., Yang, S. (2011). Cell Sources for Treating Diabetes. In Ali Gholamrezanezhad (Eds.), Stem cells in clinical research. Croatia: InTech Publishers.
  • Sahu, S., Joglekar, M., Yang, S., Hardikar, A. (2011). Gallbladder-derived islet stem cells. In unknown (Eds.), Stem Cells. Vienna, Austria: Open Access Publishers.
  • Joglekar, M., Hardikar, A. (2010). Human fetal pancreatic progenitor cells. In Phillip Stubblefield (Eds.), Clinical issues of fetal tissue transplantation in medicine. Springer.
  • Joglekar, M., Ranjan, A., Hardikar, A. (2009). Pancreas development and regeneration. In Singh, S. R. (Eds.), Stem Cells: Organogenesis and Cancer, (pp. 77-106). NIH, USA: Frontiers in Bioscience.

Journals

  • Farr, R., Joglekar, M., Taylor, C., Hardikar, A. (2013). Circulating non-coding RNAs as biomarkers of beta cell death in diabetes. Pediatric Endocrinology Reviews, 11(1), 14-20. [More Information]
  • Sundrani, D., Reddy, U., Joshi, A., Mehendale, S., Chavan-Gautam, P., Hardikar, A., Chandak, G., Joshi, S. (2013). Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia. Clinical Epigenetics, 5(1), 1-11. [More Information]
  • Satoor, S., Hardikar, A. (2013). Maternal nutrition, nutrient transfer & foetal pancreas development. Indian Journal of Medical Research, 137(2), 249-250. [More Information]
  • Hardikar, A. (2013). microRNAs: small regulators of human disease. MicroRNAs in Diabetes and Obesity (Non-coding RNAs in Endocrinology), 1, 1-2. [More Information]
  • Ranjan, A., Joglekar, M., Atre, A., Patole, M., Bhonde, R., Hardikar, A. (2012). Cellular detection of multiple antigens at single cell resolution using antibodies generated from the same species. Journal of Immunological Methods, 379(1-2), 42-47. [More Information]
  • Kumar, U., Ranjan, A., Sharan, C., Hardikar, A., Pundle, A., Poddar, P. (2012). Green approach towards size controlled synthesis of biocompatible antibacterial metal nanoparticles in aqueous phase using lysozyme. Current Nanoscience, 8(1), 130-140.
  • Hardikar, A., Walker, M., Lynn, F. (2012). Noncoding RNAs. Experimental Diabetes Research, 2012, 629249 - 1-629249 - 2. [More Information]
  • Ansarullah, Z., Bharucha, B., Umarani, M., Dwivedi, M., Laddha, N., Begum, R., Hardikar, A., Ramachandran, A. (2012). Oreocnide integrifolia Flavonoids Augment Reprogramming for Islet Neogenesis and B-Cell Regeneration in Pancreatectomized BALB/c Mice. Evidence-Based Complementary and Alternative Medicine, 2012, 1410-13. [More Information]
  • Ranjan, A., Joglekar, M., Atre, A., Patole, M., Bhonde, R., Hardikar, A. (2012). Simultaneous imaging of microRNA or mRNA territories with protein territory in mammalian cells at single cell resolution. RNA Biology, 9(7), 949-953. [More Information]
  • Forster, N., Penington, A., Hardikar, A., Palmer, J., Hussey, A., Tai, J., Morrison, W., Feeney, S. (2011). A prevascularized tissue engineering chamber supports growth and function of islets and progenitor cells in diabetic mice. Islets, 3(5), 271-283. [More Information]
  • Ansarullah, Z., Bharucha, B., Dwivedi, M., Laddha, N., Begum, R., Hardikar, A., Ramachandran, A. (2011). Antioxidant rich flavonoids from Oreocnide integrifolia enhance glucose uptake and insulin secretion and protects pancreatic (beta)-cells from streptozotocin insult. BMC Complementary and Alternative Medicine, 11, 1-13. [More Information]
  • Vaithilingam, V., Quayum, N., Joglekar, M., Jensen, J., Hardikar, A., Oberholzer, J., Guillemin, G., Tuch, B. (2011). Effect of alginate encapsulation on the cellular transcriptome of human islets. Biomaterials, 32(33), 8416-8425. [More Information]
  • Ansarullah, Z., Jayaraman, S., Hardikar, A., Ramachandran, A. (2011). Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model. Evidence-Based Complementary and Alternative Medicine, 2011, 1-9. [More Information]
  • Satoor, S., Puranik, A., Kumar, S., Williams, M., Ghale, M., Rahalkar, A., Karandikar, M., Shouche, Y., Patole, M., Bhonde, R., et al (2011). Location, location, location: Beneficial effects of autologous fat transplantation. Scientific Reports, 1, 1-10. [More Information]
  • Chayosumrit, M., Hardikar, A., Tuch, B., Sidhu, K. (2011). Role of the Glucagon-like Peptide-1 Receptor Agonist in Maintaining Pluripotency in Human Embryonic Stem Cells. The Open Stem Cell Journal, 3, 11-22. [More Information]
  • Williams, M., Mitchell, G., Hardikar, A. (2011). Stem Cells: Epigenetic Basis of Differentiation. The Open Stem Cell Journal, 3, 28-33. [More Information]
  • Wu, Y., Li, J., Saleem, S., Yee, S., Hardikar, A., Wang, R. (2010). c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells. Laboratory Investigation, 90(9), 1373-1384. [More Information]
  • Lee, J., Jo, J., Hardikar, A., Periwal, V., Rane, S. (2010). Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass. PLoS One, 5, e8653. [More Information]
  • Joglekar, M., Hardikar, A. (2010). Epithelial-to-mesenchymal transition in pancreatic islet beta cells. Cell Cycle, 9(20), 4077-4079. [More Information]
  • Khandwekar, A., Patil, D., Hardikar, A., Shouche, Y., Doble, M. (2010). In vivo modulation of foreign body response on polyurethane by surface entrapment technique. Journal of Biomedical Materials Research. Part A, 95 A (2), 413-423. [More Information]
  • Joglekar, M., Wei, C., Hardikar, A. (2010). Quantitative estimation of multiple miRNAs and mRNAs from a single cell. Cold Spring Harbor Protocols, 5(8). [More Information]
  • Mitnala, S., Pondugala, P., Guduru, V., Rabella, P., Thiyyari, J., Chivukula, S., Boddupalli, S., Hardikar, A., Reddy, D. (2010). Reduced expression of PDX-1 is associated with decreased beta cell function in chronic pancreatitis. Pancreas, 39(6), 856-852. [More Information]
  • Parekh, V., Umrani, M., Hardikar, A. (2010). Taurine supports preservation of proendocrine cell types in human umbilical cord blood-derived mononuclear cells during cryostorage. Transplantation Proceedings, 42, 4619-4621. [More Information]
  • Parekh, V., Joglekar, M., Hardikar, A. (2009). Differentiation of human umbilical cord blood-derived mononuclear cells to endocrine pancreatic lineage. Differentiation, 78(4), 232-240. [More Information]
  • Ranjan, A., Joglekar, M., Hardikar, A. (2009). Endothelial cells in pancreatic islet development and function. Islets, 34, 523-528. [More Information]
  • Joglekar, M., Joglekar, V., Hardikar, A. (2009). Expression of islet-specific microRNAs during human pancreatic development. Gene Expression Patterns, 9(2), 109-113. [More Information]
  • Ranjan, A., Kumar, U., Hardikar, A., Poddar, P., Nair, P., Hardikar, A. (2009). Human blood vessel-derived endothelial progenitors for endothelialization of small diameter vascular prosthesis. PLoS One, 4(11), 1-11. [More Information]
  • Joglekar, M., Joglekar, V., Joglekar, S., Hardikar, A. (2009). Human fetal pancreatic insulin-producing cells proliferate in vitro. Journal of Endocrinology, 201(1), 27-36. [More Information]
  • Dalvi, M., Umrani, M., Joglekar, M., Hardikar, A. (2009). Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro. Journal of Biosciences, 34(4), 523-528. [More Information]
  • Sahu, S., Joglekar, M., Dumbre, R., Phadnis, S., Tosh, D., Hardikar, A. (2009). Islet-like cell clusters occur naturally in human gall bladder and are retained in diabetic conditions. Journal of Cellular and Molecular Medicine, 13(5), 999-1000. [More Information]
  • Phadnis, S., Ghaskadbi, S., Hardikar, A., Bhonde, R. (2009). Mesenchymal stem cells derived from bone marrow of diabetic patients portrait unique markers influenced by the diabetic microenvironment. The Review of Diabetic Studies, 6(4), 260-270. [More Information]
  • Kode, J., Mukherjee, S., Joglekar, M., Hardikar, A. (2009). Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy, 11, 377-391. [More Information]
  • Sahu, S., Tosh, D., Hardikar, A. (2009). New sources of beta-cells for treating diabetes. The Journal of Endocrinology, 202(1), 13-16. [More Information]
  • Joglekar, M., Patil, D., Joglekar, V., Rao, G., Reddy, D., Mitala, S., Shouche, Y., Hardikar, A. (2009). The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells. Islets, 1(2), 137-147. [More Information]
  • Joglekar, M., Parekh, V., Mehta, S., honde, R., Hardikar, A. (2007). MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. Developmental Biology, 311(2), 603-612. [More Information]
  • Joglekar, M., Parekh, V., Hardikar, A. (2007). New pancreas from old: microregulators of pancreas regeneration. Trends in Endocrinology and Metabolism, 18(10), 393-400. [More Information]
  • Phadnis, S., Joglekar, M., Venkateshan, V., Ghaskadbi, S., Hardikar, A., Bhonde, R. (2006). Human umbilical cord blood serum promotes growth, proliferation, as well as differentiation of human bone marrow-derived progenitor cells. In Vitro Cellular & Developmental Biology. Animal, 42(10), 283-286. [More Information]
  • Hardikar, A., Lees, J., Sidhu, K., Colvin, E., Tuch, B. (2006). Stem-cell therapy for diabetes cure: how close are we? Current Stem Cell Research & Therapy, 1(3), 425-436. [More Information]
  • Gershengorn, M., Geras-Raaka, E., Hardikar, A., Raaka, B. (2005). Are better islet cell precursors generated by epithelial-to-mesenchymal transition? Cell Cycle, 4(3), 380-382. [More Information]

Conferences

  • Hardikar, A. (2013). Non coding (nc) RNAs in regenerative biology of endocrine pancreas,. Tissue Engineering and Regenerative Medicine International Society meeting, Sydney, Australia: Sheraton on the Park.
  • Hardikar, A. (2013). Quantitative real-time PCR of single cells obtained by laser catapulting microscopy. PALM Laser Catapulting Microscopy workshop, Germany.
  • Hardikar, A. (2010). Non-coding RNAs in endocrine pancreas development and function. The Islet Society meeting, Stockholm, Sweden.
  • Hardikar, A. (2009). MicroRNAs involved in epithelial-to-mesenchymal transition of human pancreatic islet cells. Australian Islet Study group meeting, Melbourne.
  • Hardikar, A. (2009). Role of miR-30 family microRNAs in epithelial-to-mesenchymal transition of human islets. EMBO workshop, Scotland.
  • Hardikar, A. (2008). Role of incretins in biochemical maturation of pancreatic islets. Asia Incretin and Islet Biology Meeting, Incheon, Korea.
  • Hardikar, A. (2008). The Thrifty Jerry: A rat model of chronic multi-generational undernutrition. Pennington Biomedical Research Symposia, Baton Rouge, USA.

2013

  • Farr, R., Joglekar, M., Taylor, C., Hardikar, A. (2013). Circulating non-coding RNAs as biomarkers of beta cell death in diabetes. Pediatric Endocrinology Reviews, 11(1), 14-20. [More Information]
  • Sundrani, D., Reddy, U., Joshi, A., Mehendale, S., Chavan-Gautam, P., Hardikar, A., Chandak, G., Joshi, S. (2013). Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia. Clinical Epigenetics, 5(1), 1-11. [More Information]
  • Joglekar, M., Hardikar, A. (2013). Human Pancreatic Progenitors: Implications for Clinical Transplantation in Diabetes. In Niranjan Bhattacharya, Phillip Stubblefield (Eds.), Human Fetal Tissue Transplantation, (pp. 237-249). London: Springer.
  • Satoor, S., Hardikar, A. (2013). Maternal nutrition, nutrient transfer & foetal pancreas development. Indian Journal of Medical Research, 137(2), 249-250. [More Information]
  • Hardikar, A. (2013). microRNAs: small regulators of human disease. MicroRNAs in Diabetes and Obesity (Non-coding RNAs in Endocrinology), 1, 1-2. [More Information]
  • Hardikar, A. (2013). Non coding (nc) RNAs in regenerative biology of endocrine pancreas,. Tissue Engineering and Regenerative Medicine International Society meeting, Sydney, Australia: Sheraton on the Park.
  • Hardikar, A. (2013). Quantitative real-time PCR of single cells obtained by laser catapulting microscopy. PALM Laser Catapulting Microscopy workshop, Germany.

2012

  • Ranjan, A., Joglekar, M., Atre, A., Patole, M., Bhonde, R., Hardikar, A. (2012). Cellular detection of multiple antigens at single cell resolution using antibodies generated from the same species. Journal of Immunological Methods, 379(1-2), 42-47. [More Information]
  • Kumar, U., Ranjan, A., Sharan, C., Hardikar, A., Pundle, A., Poddar, P. (2012). Green approach towards size controlled synthesis of biocompatible antibacterial metal nanoparticles in aqueous phase using lysozyme. Current Nanoscience, 8(1), 130-140.
  • Joglekar, M., Hardikar, A. (2012). Isolation, Expansion, and Characterization of Human Islet-Derived Progenitor Cells. In Shree Ram Singh (Eds.), Methods in Molecular Biology: Somatic Stem Cells, (pp. 351-366). New York, United States: Humana Press.
  • Hardikar, A., Walker, M., Lynn, F. (2012). Noncoding RNAs. Experimental Diabetes Research, 2012, 629249 - 1-629249 - 2. [More Information]
  • Ansarullah, Z., Bharucha, B., Umarani, M., Dwivedi, M., Laddha, N., Begum, R., Hardikar, A., Ramachandran, A. (2012). Oreocnide integrifolia Flavonoids Augment Reprogramming for Islet Neogenesis and B-Cell Regeneration in Pancreatectomized BALB/c Mice. Evidence-Based Complementary and Alternative Medicine, 2012, 1410-13. [More Information]
  • Lie, K., Chayosumrit, M., Hardikar, A., Sidhu, K. (2012). Puluripotent stem cells and diabetes: Basic Science to Clinical Applications. In Sidhu, K. S. (Eds.), Frontiers in pluripotent stem cells research: Bench-to-Bedside, (pp. 143-167). Dubai, ARE: Bentham Science Publishers.
  • Ranjan, A., Joglekar, M., Atre, A., Patole, M., Bhonde, R., Hardikar, A. (2012). Simultaneous imaging of microRNA or mRNA territories with protein territory in mammalian cells at single cell resolution. RNA Biology, 9(7), 949-953. [More Information]

2011

  • Forster, N., Penington, A., Hardikar, A., Palmer, J., Hussey, A., Tai, J., Morrison, W., Feeney, S. (2011). A prevascularized tissue engineering chamber supports growth and function of islets and progenitor cells in diabetic mice. Islets, 3(5), 271-283. [More Information]
  • Ansarullah, Z., Bharucha, B., Dwivedi, M., Laddha, N., Begum, R., Hardikar, A., Ramachandran, A. (2011). Antioxidant rich flavonoids from Oreocnide integrifolia enhance glucose uptake and insulin secretion and protects pancreatic (beta)-cells from streptozotocin insult. BMC Complementary and Alternative Medicine, 11, 1-13. [More Information]
  • Joglekar, M., Hardikar, A., Sahu, S., Yang, S. (2011). Cell Sources for Treating Diabetes. In Ali Gholamrezanezhad (Eds.), Stem cells in clinical research. Croatia: InTech Publishers.
  • Vaithilingam, V., Quayum, N., Joglekar, M., Jensen, J., Hardikar, A., Oberholzer, J., Guillemin, G., Tuch, B. (2011). Effect of alginate encapsulation on the cellular transcriptome of human islets. Biomaterials, 32(33), 8416-8425. [More Information]
  • Sahu, S., Joglekar, M., Yang, S., Hardikar, A. (2011). Gallbladder-derived islet stem cells. In unknown (Eds.), Stem Cells. Vienna, Austria: Open Access Publishers.
  • Ansarullah, Z., Jayaraman, S., Hardikar, A., Ramachandran, A. (2011). Influence of Oreocnide integrifolia (Gaud.) Miq on IRS-1, Akt and Glut-4 in Fat-Fed C57BL/6J Type 2 Diabetes Mouse Model. Evidence-Based Complementary and Alternative Medicine, 2011, 1-9. [More Information]
  • Satoor, S., Puranik, A., Kumar, S., Williams, M., Ghale, M., Rahalkar, A., Karandikar, M., Shouche, Y., Patole, M., Bhonde, R., et al (2011). Location, location, location: Beneficial effects of autologous fat transplantation. Scientific Reports, 1, 1-10. [More Information]
  • Chayosumrit, M., Hardikar, A., Tuch, B., Sidhu, K. (2011). Role of the Glucagon-like Peptide-1 Receptor Agonist in Maintaining Pluripotency in Human Embryonic Stem Cells. The Open Stem Cell Journal, 3, 11-22. [More Information]
  • Williams, M., Mitchell, G., Hardikar, A. (2011). Stem Cells: Epigenetic Basis of Differentiation. The Open Stem Cell Journal, 3, 28-33. [More Information]

2010

  • Wu, Y., Li, J., Saleem, S., Yee, S., Hardikar, A., Wang, R. (2010). c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells. Laboratory Investigation, 90(9), 1373-1384. [More Information]
  • Lee, J., Jo, J., Hardikar, A., Periwal, V., Rane, S. (2010). Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass. PLoS One, 5, e8653. [More Information]
  • Joglekar, M., Hardikar, A. (2010). Epithelial-to-mesenchymal transition in pancreatic islet beta cells. Cell Cycle, 9(20), 4077-4079. [More Information]
  • Joglekar, M., Hardikar, A. (2010). Human fetal pancreatic progenitor cells. In Phillip Stubblefield (Eds.), Clinical issues of fetal tissue transplantation in medicine. Springer.
  • Khandwekar, A., Patil, D., Hardikar, A., Shouche, Y., Doble, M. (2010). In vivo modulation of foreign body response on polyurethane by surface entrapment technique. Journal of Biomedical Materials Research. Part A, 95 A (2), 413-423. [More Information]
  • Hardikar, A. (2010). Non-coding RNAs in endocrine pancreas development and function. The Islet Society meeting, Stockholm, Sweden.
  • Joglekar, M., Wei, C., Hardikar, A. (2010). Quantitative estimation of multiple miRNAs and mRNAs from a single cell. Cold Spring Harbor Protocols, 5(8). [More Information]
  • Mitnala, S., Pondugala, P., Guduru, V., Rabella, P., Thiyyari, J., Chivukula, S., Boddupalli, S., Hardikar, A., Reddy, D. (2010). Reduced expression of PDX-1 is associated with decreased beta cell function in chronic pancreatitis. Pancreas, 39(6), 856-852. [More Information]
  • Parekh, V., Umrani, M., Hardikar, A. (2010). Taurine supports preservation of proendocrine cell types in human umbilical cord blood-derived mononuclear cells during cryostorage. Transplantation Proceedings, 42, 4619-4621. [More Information]

2009

  • Parekh, V., Joglekar, M., Hardikar, A. (2009). Differentiation of human umbilical cord blood-derived mononuclear cells to endocrine pancreatic lineage. Differentiation, 78(4), 232-240. [More Information]
  • Ranjan, A., Joglekar, M., Hardikar, A. (2009). Endothelial cells in pancreatic islet development and function. Islets, 34, 523-528. [More Information]
  • Joglekar, M., Joglekar, V., Hardikar, A. (2009). Expression of islet-specific microRNAs during human pancreatic development. Gene Expression Patterns, 9(2), 109-113. [More Information]
  • Ranjan, A., Kumar, U., Hardikar, A., Poddar, P., Nair, P., Hardikar, A. (2009). Human blood vessel-derived endothelial progenitors for endothelialization of small diameter vascular prosthesis. PLoS One, 4(11), 1-11. [More Information]
  • Joglekar, M., Joglekar, V., Joglekar, S., Hardikar, A. (2009). Human fetal pancreatic insulin-producing cells proliferate in vitro. Journal of Endocrinology, 201(1), 27-36. [More Information]
  • Dalvi, M., Umrani, M., Joglekar, M., Hardikar, A. (2009). Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro. Journal of Biosciences, 34(4), 523-528. [More Information]
  • Sahu, S., Joglekar, M., Dumbre, R., Phadnis, S., Tosh, D., Hardikar, A. (2009). Islet-like cell clusters occur naturally in human gall bladder and are retained in diabetic conditions. Journal of Cellular and Molecular Medicine, 13(5), 999-1000. [More Information]
  • Phadnis, S., Ghaskadbi, S., Hardikar, A., Bhonde, R. (2009). Mesenchymal stem cells derived from bone marrow of diabetic patients portrait unique markers influenced by the diabetic microenvironment. The Review of Diabetic Studies, 6(4), 260-270. [More Information]
  • Kode, J., Mukherjee, S., Joglekar, M., Hardikar, A. (2009). Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy, 11, 377-391. [More Information]
  • Hardikar, A. (2009). MicroRNAs involved in epithelial-to-mesenchymal transition of human pancreatic islet cells. Australian Islet Study group meeting, Melbourne.
  • Sahu, S., Tosh, D., Hardikar, A. (2009). New sources of beta-cells for treating diabetes. The Journal of Endocrinology, 202(1), 13-16. [More Information]
  • Joglekar, M., Ranjan, A., Hardikar, A. (2009). Pancreas development and regeneration. In Singh, S. R. (Eds.), Stem Cells: Organogenesis and Cancer, (pp. 77-106). NIH, USA: Frontiers in Bioscience.
  • Hardikar, A. (2009). Role of miR-30 family microRNAs in epithelial-to-mesenchymal transition of human islets. EMBO workshop, Scotland.
  • Joglekar, M., Patil, D., Joglekar, V., Rao, G., Reddy, D., Mitala, S., Shouche, Y., Hardikar, A. (2009). The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells. Islets, 1(2), 137-147. [More Information]

2008

  • Hardikar, A. (2008). Role of incretins in biochemical maturation of pancreatic islets. Asia Incretin and Islet Biology Meeting, Incheon, Korea.
  • Hardikar, A. (2008). The Thrifty Jerry: A rat model of chronic multi-generational undernutrition. Pennington Biomedical Research Symposia, Baton Rouge, USA.

2007

  • Joglekar, M., Parekh, V., Mehta, S., honde, R., Hardikar, A. (2007). MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. Developmental Biology, 311(2), 603-612. [More Information]
  • Joglekar, M., Parekh, V., Hardikar, A. (2007). New pancreas from old: microregulators of pancreas regeneration. Trends in Endocrinology and Metabolism, 18(10), 393-400. [More Information]

2006

  • Phadnis, S., Joglekar, M., Venkateshan, V., Ghaskadbi, S., Hardikar, A., Bhonde, R. (2006). Human umbilical cord blood serum promotes growth, proliferation, as well as differentiation of human bone marrow-derived progenitor cells. In Vitro Cellular & Developmental Biology. Animal, 42(10), 283-286. [More Information]
  • Hardikar, A., Lees, J., Sidhu, K., Colvin, E., Tuch, B. (2006). Stem-cell therapy for diabetes cure: how close are we? Current Stem Cell Research & Therapy, 1(3), 425-436. [More Information]

2005

  • Gershengorn, M., Geras-Raaka, E., Hardikar, A., Raaka, B. (2005). Are better islet cell precursors generated by epithelial-to-mesenchymal transition? Cell Cycle, 4(3), 380-382. [More Information]

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