Dr Andrew Biggin

BSc PhD MBBS FRACP
Senior Lecturer
Child and Adolescent Health
Children's Hospital at Westmead Clinical School


Website drbiggin.com

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Biographical details

Andrew is an Endocrinologist at the Children's Hospital at Westmead and a Senior Lecturer in the Discipline of Child & Adolescent Health. He obtained his PhD from the University of London looking at mechanisms of neuromuscular junction plasticity. He has been involved with the Children's Hospital Clinical School since 2006 and supervised a number of Masters and PhD candidates. He has a background in biochemistry and molecular biology and has developed a number of screening tests for mitochondrial disorders, Marfan syndrome and related conditions. Following completion of his Endocrine training he has developed a keen interest in bone dysplasias, metabolic bone disease and osteoporosis and this is his current primary research focus. He also has an interest in using IT to develop innovative ways to improve patient care and aid clinical research & teaching.

Current projects

Whole genome sequencing to identify new genetic disorders of the skeleton and explore the phenotypic spectrum associated with these mutations.

A randomized study to assess the efficacy and safety of KRN23(a recombinant human monoclonal antibody to fibroblast growth factor 23) versus oral phosphate and active Vitamin D treatment in pediatric patients with X-linked Hypophosphatemia (XLH)

Preserving beta-cell function with Tocilizumab in children with new-onset Type 1 Diabetes.

An observational, longitudinal, prospective, long-term registry of patients with hypophosphatasia.

A prospective, multicentre, single-arm study to evaluate the safety, efficacy and pharmacokinetics of Denosumab in children with osteogenesis imperfecta.

A multicenter, randomized, double-blind, placebo controlled efficacy and safety trial of intravenous zoledronic acid twice yearly compared to placebo in osteoporotic children treated with glucocorticoids for chronic inflammatory conditions.

The safety and efficacy of Stoss therapy in the treatment of Vitamin D deficiency.

Bisphosphonate treatment of childhood femoral head avascular necrosis due to Perthes disease.

Awards and honours

2017 - The Vice-Chancellor’s Award for Outstanding Research Higher Degree Supervision

2016 -Diabetes advocate recognition award, Danii Foundation

2013 - New Investigator Award. International Conference on Children's Bone Health, Rotterdam, Netherlands

Keywords

Osteoporosis; Bone health; Endocrinology

Clinical Specialty

Endocrinology

Selected publications

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Book Chapters

  • Biggin, A., Munns, C. (2014). Bisphosphonates in Osteogenesis Imperfecta. In Gordon L. Klein (Eds.), Bone Drugs in Pediatrics: Efficacy and Challenges, (pp. 67-80). New York: Springer. [More Information]

Journals

  • Simm, P., Biggin, A., Zacharin, M., Rodda, C., Tham, E., Siafarikas, A., Jefferies, C., Hofman, P., Jensen, D., Woodhead, H., Munns, C., et al (2018). Consensus guidelines on the use of bisphosphonate therapy in children and adolescents. Journal of Paediatrics and Child Health, 54(3), 223-233. [More Information]
  • Fiscaletti, M., Coorey, C., Biggin, A., Briody, J., Little, D., Schindeler, A., Munns, C. (2018). Diagnosis of Recurrent Fracture in a Pediatric Cohort. Calcified Tissue International, 103, 529-539. [More Information]
  • Biggin, A., Enriquez, A., Wong, M., Bennetts, B., Lau, C., Chan, C., Pinner, J., Adelstein, S., Ades, L. (2018). Hemophagocytic Lymphohistiocytosis in Loeys-Dietz Syndrome. Journal of Clinical Immunology, 38(3), 234-236. [More Information]
  • Fiscaletti, M., Biggin, A., Bennetts, B., Wong, K., Briody, J., Pacey, V., Birman, C., Munns, C. (2018). Novel variant in Sp7/Osx associated with recessive osteogenesis imperfecta with bone fragility and hearing impairment. Bone, 110, 66-75. [More Information]
  • Biggin, A., Munns, C. (2017). Long-Term Bisphosphonate Therapy in Osteogenesis Imperfecta. Current Osteoporosis Reports, 15(5), 412-418. [More Information]
  • Korula, S., Titmuss, A., Biggin, A., Munns, C. (2015). A Practical Approach to Children with Recurrent Fractures. Endocrine Development, 28, 210-225. [More Information]
  • Munns, C., Fahiminiya, S., Poudel, N., Munteanu, M., Majewski, J., Sillence, D., Metcalf, J., Biggin, A., Glorieux, F., Fassier, F., et al (2015). Homozygosity for Frameshift Mutations in XYLT2 Result in a Spondylo-Ocular Syndrome with Bone Fragility, Cataracts, and Hearing Defects. American Journal of Human Genetics, 96(6), 971-978. [More Information]
  • Biggin, A., Zheng, L., Briody, J., Coorey, C., Munns, C. (2015). The long-term effects of switching from active intravenous bisphosphonate treatment to low-dose maintenance therapy in children with osteogenesis imperfecta. Hormone Research in Paediatrics, 83(3), 183-189. [More Information]
  • Biggin, A., Briody, J., Ormshaw, E., Wong, K., Bennetts, B., Munns, C. (2014). Fracture during Intravenous Bisphosphonate Treatment in a Child with Osteogenesis Imperfecta: An Argument for a More Frequent, Low-Dose Treatment Regimen. Hormone Research in Paediatrics, 81(3), 204-210. [More Information]
  • Dasgupta, D., Wee, M., Reyes, M., Li, Y., Simm, P., Sharma, A., Schlingmann, K., Janner, M., Biggin, A., Lazier, J., Munns, C., et al (2014). Mutations in SLC34A3/NPT2c Are Associated with Kidney Stones and Nephrocalcinosis. Journal of the American Society of Nephrology, 25(10), 2366-2375. [More Information]
  • Biggin, A., Munns, C. (2014). Osteogenesis Imperfecta: Diagnosis and Treatment. Current Osteoporosis Reports, 12(3), 279-288. [More Information]
  • Biggin, A., Briody, J., Ramjan, K., Middleton, A., Waugh, M., Munns, C. (2013). Evaluation of bone mineral density and morphology using pQCT in children after spinal cord injury. Developmental Neurorehabilitation, 16(6), 391-397. [More Information]
  • Ooi, H., Briody, J., Biggin, A., Cowell, C., Munns, C. (2013). Intravenous Zoledronic Acid Given Every 6 Months in Childhood Osteoporosis. Hormone Research in Paediatrics, 80(3), 179-184. [More Information]
  • Ades, L., Sullivan, K., Biggin, A., Haan, E., Brett, M., Holman, K., Dixon, J., Robertson, S., Holmes, A., Rogers, J., Bennetts, B. (2006). FBN1, TGFBR1, and the Marfan-craniosynostosis/mental retardation disorders revisited. American Journal of Medical Genetics, Part A, 140(10), 1047-1058. [More Information]
  • Biggin, A., Henke, R., Bennetts, B., Thorburn, D., Christodoulou, J. (2005). Mutation screening of the mitochondrial genome using denaturing high-performance liquid chromatography. Molecular Genetics and Metabolism, 84(1), 61-74. [More Information]

2018

  • Simm, P., Biggin, A., Zacharin, M., Rodda, C., Tham, E., Siafarikas, A., Jefferies, C., Hofman, P., Jensen, D., Woodhead, H., Munns, C., et al (2018). Consensus guidelines on the use of bisphosphonate therapy in children and adolescents. Journal of Paediatrics and Child Health, 54(3), 223-233. [More Information]
  • Fiscaletti, M., Coorey, C., Biggin, A., Briody, J., Little, D., Schindeler, A., Munns, C. (2018). Diagnosis of Recurrent Fracture in a Pediatric Cohort. Calcified Tissue International, 103, 529-539. [More Information]
  • Biggin, A., Enriquez, A., Wong, M., Bennetts, B., Lau, C., Chan, C., Pinner, J., Adelstein, S., Ades, L. (2018). Hemophagocytic Lymphohistiocytosis in Loeys-Dietz Syndrome. Journal of Clinical Immunology, 38(3), 234-236. [More Information]
  • Fiscaletti, M., Biggin, A., Bennetts, B., Wong, K., Briody, J., Pacey, V., Birman, C., Munns, C. (2018). Novel variant in Sp7/Osx associated with recessive osteogenesis imperfecta with bone fragility and hearing impairment. Bone, 110, 66-75. [More Information]

2017

  • Biggin, A., Munns, C. (2017). Long-Term Bisphosphonate Therapy in Osteogenesis Imperfecta. Current Osteoporosis Reports, 15(5), 412-418. [More Information]

2015

  • Korula, S., Titmuss, A., Biggin, A., Munns, C. (2015). A Practical Approach to Children with Recurrent Fractures. Endocrine Development, 28, 210-225. [More Information]
  • Munns, C., Fahiminiya, S., Poudel, N., Munteanu, M., Majewski, J., Sillence, D., Metcalf, J., Biggin, A., Glorieux, F., Fassier, F., et al (2015). Homozygosity for Frameshift Mutations in XYLT2 Result in a Spondylo-Ocular Syndrome with Bone Fragility, Cataracts, and Hearing Defects. American Journal of Human Genetics, 96(6), 971-978. [More Information]
  • Biggin, A., Zheng, L., Briody, J., Coorey, C., Munns, C. (2015). The long-term effects of switching from active intravenous bisphosphonate treatment to low-dose maintenance therapy in children with osteogenesis imperfecta. Hormone Research in Paediatrics, 83(3), 183-189. [More Information]

2014

  • Biggin, A., Munns, C. (2014). Bisphosphonates in Osteogenesis Imperfecta. In Gordon L. Klein (Eds.), Bone Drugs in Pediatrics: Efficacy and Challenges, (pp. 67-80). New York: Springer. [More Information]
  • Biggin, A., Briody, J., Ormshaw, E., Wong, K., Bennetts, B., Munns, C. (2014). Fracture during Intravenous Bisphosphonate Treatment in a Child with Osteogenesis Imperfecta: An Argument for a More Frequent, Low-Dose Treatment Regimen. Hormone Research in Paediatrics, 81(3), 204-210. [More Information]
  • Dasgupta, D., Wee, M., Reyes, M., Li, Y., Simm, P., Sharma, A., Schlingmann, K., Janner, M., Biggin, A., Lazier, J., Munns, C., et al (2014). Mutations in SLC34A3/NPT2c Are Associated with Kidney Stones and Nephrocalcinosis. Journal of the American Society of Nephrology, 25(10), 2366-2375. [More Information]
  • Biggin, A., Munns, C. (2014). Osteogenesis Imperfecta: Diagnosis and Treatment. Current Osteoporosis Reports, 12(3), 279-288. [More Information]

2013

  • Biggin, A., Briody, J., Ramjan, K., Middleton, A., Waugh, M., Munns, C. (2013). Evaluation of bone mineral density and morphology using pQCT in children after spinal cord injury. Developmental Neurorehabilitation, 16(6), 391-397. [More Information]
  • Ooi, H., Briody, J., Biggin, A., Cowell, C., Munns, C. (2013). Intravenous Zoledronic Acid Given Every 6 Months in Childhood Osteoporosis. Hormone Research in Paediatrics, 80(3), 179-184. [More Information]

2006

  • Ades, L., Sullivan, K., Biggin, A., Haan, E., Brett, M., Holman, K., Dixon, J., Robertson, S., Holmes, A., Rogers, J., Bennetts, B. (2006). FBN1, TGFBR1, and the Marfan-craniosynostosis/mental retardation disorders revisited. American Journal of Medical Genetics, Part A, 140(10), 1047-1058. [More Information]

2005

  • Biggin, A., Henke, R., Bennetts, B., Thorburn, D., Christodoulou, J. (2005). Mutation screening of the mitochondrial genome using denaturing high-performance liquid chromatography. Molecular Genetics and Metabolism, 84(1), 61-74. [More Information]

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