Dr Andrew Harman

Coordinator of Medical Sciences at Westmead
Senior Research Fellow, The Westmead Institute for Medical Research

Telephone +61 2 9845 9118
Fax +61 2 9845 9103

Website Honours in Medical Sciences at Westmead

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Biographical details

Andrew Harman is the coordinator of medical sciences at Westmead and is responsible for implementing a new Westmead based honours program in medical sciences. He is also the Westmead talented student program coordinator.

After completing his PhD at the University of Cambridge in 2002, Andrew has been working at The Westmead Institute for Medical Research where he is now a group leader. His group researches mucosal immunology and sexual transmission of HIV.

Research interests

Andrew's primary interest is in mucosal immunology and investigating sexual transmission of HIV. He has developed extensive collaborations with a range of sexual health specialists, as well as plastic, colorectal, gynaecological and urological surgeons.Therefore he has access to all the human tissues that sexually transmitted pathogens encounter during sexual intercourse (labia, vagina, cervix, foreskin, glans penis, urethra, anus and rectum). Regular access tothese tissue gives his group a translational cutting edge as they are one of the only research groups worldwide that has access to such a comprehensive range of anogenital tissue. Andrew's group also has access to human intestinal tissue and they are beginning to investigate the mucosal immunology associated with autoinflammatory diseases such as Crohn's disease and ulcerative colitis.

Current research students

Project title Research student
Investigating the role of anorectal dendritic cells and macrophages in sexual transmission of HIV Heeva BAHARLOU
The Role of Mucosal Dendritic Cells in the Sexual Transmission of HIV Hafsa RANA

Selected grants

2016

  • Defining the Interaction of HIV with the Interferon System in Initial Mucosal Infection; Cunningham A, Harman A, Palmer S, Nasr N, Diefenbach R, Sandgren K; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • The Role of Dendritic Cells in Sexual Transmission of HIV and Viral Reservoir Formation; Harman A, Cunningham A, Palmer S, Kim M, Nasr N; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • The Role of Dendritic Cells in Sexual Transmission of HIV and viral rosend formation; Harman A; DVC Research/Bridging Support Grant.
  • NanoString nCounter Platform; deFazio A, Alexander I, Booth D, Byrne J, Christodoulou J, Clarke C, Cunningham A, George J, Graham J, Harman A, Liddle C, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Cell type specific biologic responses to HIV infection; Cunningham A, Turville S, Harman A, Turville S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Nasr, N., Harman, A., Turville, S., Cunningham, A. (2014). HIV infection of dendritic cells. In Elisa Vincenzi, Guido Poli (Eds.), Human Retroviruses: Method and Protocols, (pp. 221-232). New York: Humana Press. [More Information]
  • Cunningham, A., Harman, A., Kim, M., Nasr, N., Lai, J. (2013). Immunobiology of Dendritic Cells and the Influence of HIV Infection. In Li Wu, Olivier Schwartz (Eds.), HIV Interactions with Dendritic Cells: Infection and Immunity, (pp. 1-44). New York, USA: Springer Science+Business Media.

Journals

  • Clark, G., Kupresanin, F., Fromm, P., Ju, X., Muusers, L., Silveira, P., Elgundi, Z., Gasiorowski, R., Papadimitrious, M., Bryant, C., Lee, K., Harman, A., Hart, D., et al (2016). New insights into the phenotype of human dendritic cell populations. Clinical & Translational Immunology, 5(1), 1-12. [More Information]
  • Marsden, V., Donaghy, H., Bertram, K., Harman, A., Nasr, N., Keoshkerian, E., Merten, S., Lloyd, A., Cunningham, A. (2015). Herpes Simplex Virus Type 2–Infected Dendritic Cells Produce TNF-a, Which Enhances CCR5 Expression and Stimulates HIV Production from Adjacent Infected Cells. The Journal of Immunology, 194(9), 4438-4445. [More Information]
  • Harman, A., Nasr, N., Feetham, A., Galoyan, A., Alshehri,, A., Rambukwelle, D., Botting, R., Hiener, B., Diefenbach, E., Diefenbach, R., Kim, M., Cunningham, A., et al (2015). HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1. Journal of Virology, 89(13), 6575-6584. [More Information]
  • Kim, M., Truong, N., James, V., Bosnjak, L., Sandgren, K., Harman, A., Nasr, N., Bertram, K., Olbourne, N., Sawleshwarkar, S., Cunningham, A., et al (2015). Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. PLoS Pathogens, 11(4), 1-19. [More Information]
  • Nasr, N., Lai, J., Botting, R., Mercier, S., Harman, A., Kim, M., Turville, S., Center, R., Domagala, T., Gorry, P., Cunningham, A., et al (2014). Inhibition of Two Temporal Phases of HIV-1 Transfer from Primary Langerhans Cells to T Cells: The Role of Langerin. The Journal of Immunology, 193(5), 2554-2564. [More Information]
  • Wightman, F., Hao, K., Solomon, A., Saleh, S., Harman, A., Cunningham, A., Gray, L., Churchill, M., Cameron, P., Dear, A., et al (2013). Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells. AIDS, 27(18), 2853-2862. [More Information]
  • Harman, A., Bye, C., Nasr, N., Sandgren, K., Kim, M., Mercier, S., Botting, R., Lewin, S., Cunningham, A., Cameron, P. (2013). Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells. The Journal of Immunology, 190(1), 66-79. [More Information]
  • Cunningham, A., Harman, A., Nasr, N. (2013). Initial HIV mucosal infection and dendritic cells. EMBO Molecular Medicine, 5(5), 658-660. [More Information]
  • Mercier, S., Donaghy, H., Botting, R., Turville, S., Harman, A., Nasr, N., Ji, H., Kusebauch, U., Mendoza, L., Shteynberg, D., Cunningham, A., et al (2013). The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes. PLoS Pathogens, 9(10), 1-18. [More Information]
  • Harman, A., Kim, M., Nasr, N., Sandgren, K., Cameron, P. (2013). Tissue dendritic cells as portals for HIV entry. Reviews in Medical Virology, 23(5), 319-333. [More Information]
  • Nasr, N., Maddocks, S., Turville, S., Harman, A., Woolger, N., Helbig, K., Wilkinson, J., Bye, C., Wright, T., Rambukwelle, D., Donaghy, H., Cunningham, A., et al (2012). HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood, 120(4), 778-788. [More Information]
  • Harman, A., Lai, J., Turville, S., Samarajiwa, S., Gray, L., Marsden, V., Mercier, S., Jones, K., Nasr, N., Rustagi, A., Cunningham, A., et al (2011). HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production. Blood, 118(2), 298-308. [More Information]
  • Cameron, P., Saleh, S., Sallmann, G., Solomon, A., Wightman, F., Evans, V., Boucher, G., Haddad, E., Sekaly, R., Harman, A., Cunningham, A., et al (2010). Establishment of HIV-1 Latency in Resting CD4+ T Cells Depends on Chemokine-Induced Changes in the Actin Cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(39), 16934-16939. [More Information]
  • Cunningham, A., Donaghy, H., Harman, A., Turville, S. (2010). Manipulation of dendritic cell function by viruses. Current Opinion in Microbiology, 13(4), 524-9. [More Information]
  • Harman, A., Kraus, M., Bye, C., Byth Wilson, K., Turville, S., Tang, O., Mercier, S., Nasr, N., Stern, J., Slobedman, B., Cunningham, A., et al (2009). HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood, 114(1), 85-94. [More Information]
  • Lai, J., Bernhard, O., Turville, S., Harman, A., Wilkinson, J. (2009). Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1. Journal of Biological Chemistry, 284(17), 11027-11038. [More Information]
  • Donaghy, H., Bosnjak, L., Harman, A., Marsden, V., Tyring, S., Meng, T., Cunningham, A. (2009). Role for Plasmacytoid Dendritic Cells in the Immune Control of Recurrent Human Herpes Simplex Virus Infection. Journal of Virology, 83(4), 1952-1961. [More Information]
  • Cunningham, A., Harman, A., Donaghy, H. (2007). DC-SIGN 'AIDS' HIV immune evasion and infection. Nature Immunology, 8(6), 556-558. [More Information]
  • Watson, S., Mercier, S., Bye, C., Wilkinson, J., Cunningham, A., Harman, A. (2007). Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses. Virology Journal, 4(130), 1-5. [More Information]
  • Harman, A., Wilkinson, J., Bye, C., Bosnjak, L., Stern, J., Nicholle, M., Lai, J., Cunningham, A. (2006). HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells. The Journal of Immunology, 177(10), 7103-7113. [More Information]

2016

  • Clark, G., Kupresanin, F., Fromm, P., Ju, X., Muusers, L., Silveira, P., Elgundi, Z., Gasiorowski, R., Papadimitrious, M., Bryant, C., Lee, K., Harman, A., Hart, D., et al (2016). New insights into the phenotype of human dendritic cell populations. Clinical & Translational Immunology, 5(1), 1-12. [More Information]

2015

  • Marsden, V., Donaghy, H., Bertram, K., Harman, A., Nasr, N., Keoshkerian, E., Merten, S., Lloyd, A., Cunningham, A. (2015). Herpes Simplex Virus Type 2–Infected Dendritic Cells Produce TNF-a, Which Enhances CCR5 Expression and Stimulates HIV Production from Adjacent Infected Cells. The Journal of Immunology, 194(9), 4438-4445. [More Information]
  • Harman, A., Nasr, N., Feetham, A., Galoyan, A., Alshehri,, A., Rambukwelle, D., Botting, R., Hiener, B., Diefenbach, E., Diefenbach, R., Kim, M., Cunningham, A., et al (2015). HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1. Journal of Virology, 89(13), 6575-6584. [More Information]
  • Kim, M., Truong, N., James, V., Bosnjak, L., Sandgren, K., Harman, A., Nasr, N., Bertram, K., Olbourne, N., Sawleshwarkar, S., Cunningham, A., et al (2015). Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. PLoS Pathogens, 11(4), 1-19. [More Information]

2014

  • Nasr, N., Harman, A., Turville, S., Cunningham, A. (2014). HIV infection of dendritic cells. In Elisa Vincenzi, Guido Poli (Eds.), Human Retroviruses: Method and Protocols, (pp. 221-232). New York: Humana Press. [More Information]
  • Nasr, N., Lai, J., Botting, R., Mercier, S., Harman, A., Kim, M., Turville, S., Center, R., Domagala, T., Gorry, P., Cunningham, A., et al (2014). Inhibition of Two Temporal Phases of HIV-1 Transfer from Primary Langerhans Cells to T Cells: The Role of Langerin. The Journal of Immunology, 193(5), 2554-2564. [More Information]

2013

  • Wightman, F., Hao, K., Solomon, A., Saleh, S., Harman, A., Cunningham, A., Gray, L., Churchill, M., Cameron, P., Dear, A., et al (2013). Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells. AIDS, 27(18), 2853-2862. [More Information]
  • Harman, A., Bye, C., Nasr, N., Sandgren, K., Kim, M., Mercier, S., Botting, R., Lewin, S., Cunningham, A., Cameron, P. (2013). Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells. The Journal of Immunology, 190(1), 66-79. [More Information]
  • Cunningham, A., Harman, A., Kim, M., Nasr, N., Lai, J. (2013). Immunobiology of Dendritic Cells and the Influence of HIV Infection. In Li Wu, Olivier Schwartz (Eds.), HIV Interactions with Dendritic Cells: Infection and Immunity, (pp. 1-44). New York, USA: Springer Science+Business Media.
  • Cunningham, A., Harman, A., Nasr, N. (2013). Initial HIV mucosal infection and dendritic cells. EMBO Molecular Medicine, 5(5), 658-660. [More Information]
  • Mercier, S., Donaghy, H., Botting, R., Turville, S., Harman, A., Nasr, N., Ji, H., Kusebauch, U., Mendoza, L., Shteynberg, D., Cunningham, A., et al (2013). The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes. PLoS Pathogens, 9(10), 1-18. [More Information]
  • Harman, A., Kim, M., Nasr, N., Sandgren, K., Cameron, P. (2013). Tissue dendritic cells as portals for HIV entry. Reviews in Medical Virology, 23(5), 319-333. [More Information]

2012

  • Nasr, N., Maddocks, S., Turville, S., Harman, A., Woolger, N., Helbig, K., Wilkinson, J., Bye, C., Wright, T., Rambukwelle, D., Donaghy, H., Cunningham, A., et al (2012). HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood, 120(4), 778-788. [More Information]

2011

  • Harman, A., Lai, J., Turville, S., Samarajiwa, S., Gray, L., Marsden, V., Mercier, S., Jones, K., Nasr, N., Rustagi, A., Cunningham, A., et al (2011). HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production. Blood, 118(2), 298-308. [More Information]

2010

  • Cameron, P., Saleh, S., Sallmann, G., Solomon, A., Wightman, F., Evans, V., Boucher, G., Haddad, E., Sekaly, R., Harman, A., Cunningham, A., et al (2010). Establishment of HIV-1 Latency in Resting CD4+ T Cells Depends on Chemokine-Induced Changes in the Actin Cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(39), 16934-16939. [More Information]
  • Cunningham, A., Donaghy, H., Harman, A., Turville, S. (2010). Manipulation of dendritic cell function by viruses. Current Opinion in Microbiology, 13(4), 524-9. [More Information]

2009

  • Harman, A., Kraus, M., Bye, C., Byth Wilson, K., Turville, S., Tang, O., Mercier, S., Nasr, N., Stern, J., Slobedman, B., Cunningham, A., et al (2009). HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood, 114(1), 85-94. [More Information]
  • Lai, J., Bernhard, O., Turville, S., Harman, A., Wilkinson, J. (2009). Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1. Journal of Biological Chemistry, 284(17), 11027-11038. [More Information]
  • Donaghy, H., Bosnjak, L., Harman, A., Marsden, V., Tyring, S., Meng, T., Cunningham, A. (2009). Role for Plasmacytoid Dendritic Cells in the Immune Control of Recurrent Human Herpes Simplex Virus Infection. Journal of Virology, 83(4), 1952-1961. [More Information]

2007

  • Cunningham, A., Harman, A., Donaghy, H. (2007). DC-SIGN 'AIDS' HIV immune evasion and infection. Nature Immunology, 8(6), 556-558. [More Information]
  • Watson, S., Mercier, S., Bye, C., Wilkinson, J., Cunningham, A., Harman, A. (2007). Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses. Virology Journal, 4(130), 1-5. [More Information]

2006

  • Harman, A., Wilkinson, J., Bye, C., Bosnjak, L., Stern, J., Nicholle, M., Lai, J., Cunningham, A. (2006). HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells. The Journal of Immunology, 177(10), 7103-7113. [More Information]

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