Dr Andrew Hoy
Physiology, School of Medical Sciences
|Telephone||02 9351 2514|
Dr Hoy is Head of the Lipid Metabolism Laboratory in the Discipline of Physiology SoMS and Bosch Institute as well as an Honorary Associate position with the Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders. He received his PhD training at the Garvan Institute of Medical Research within the Diabetes and Obesity Research Program. Following this he did his Post-Doctoral training in the laboratory of Prof Matthew Watt at Monash University, as a NHMRC Biomedical Australia training Fellow,which has lead to his current research interest in lipid metabolism and how it is perturbed in Obesity, Diabetes and Cancer.
Dr Hoy is currently an active member of Australian Diabetes Society (since 2006), Australian Physiological Society (since 2001), Australian Society of Medical Research (since 2007), and American Society for Biochemistry and Molecular Biology (since 2011).
Research conducted by my laboratory is focused on the regulation of lipid metabolism, predominantly fatty acid storage and utilisation, and how this may be perturbed in chronic disease states such as cancer, obesity and insulin resistance.
Current Laboratory Members:
- Miss Seher Balaban - PhD Student
- Mr Harrison Shtein -MPhil Student
- Mr Tim Nguyen -MPhil Student
- Miss Lisa Lee - BSc Hons Student
The Lipid Metabolism Laboratory has two major research themes:
Lipid Metabolism and Insulin Resistance
The accumulation of lipid in tissue responsible for regulating blood glucose levels, including skeletal muscle and liver, results in the insulin resistance. The vast majority of fatty acids are stored in the lipid droplet as triacylglycerols. Hence, the lipid droplet is at the centre of intracellular lipid homeostasis. However, triacylglycerols are not mechanistically linked to the development of insulin resistance. Other lipid species that can arise from lipid processes that occur at the lipid droplet have been. This theme aims to understand the role of the metabolic processes that occur at the lipid droplet that are altered with insulin resistance.
Lipid Metabolism and Cancer
Metabolic diseases such as obesity and insulin resistance are risk factors for some cancers. Cancer is characterised by a dramatic shift in their metabolic phenotype, primarily towards non-oxidative metabolism and increased lipid synthesis. That said, the role of fatty acid metabolism in the sustained growth of cancer cells has yet to be fully elucidated. This theme aims to characterise the fatty acid metabolism of cancer cells and its role as a therapeutic target.
Awards and honours
2013 CASS Foundation Travel Grant ($3000)
2011 Molecular & Cellular Biology of Lipids Gordon Research Conference Junior Scientist Travel Award (USD$500)
2011 Monash Obesity and Diabetes Institute Travel Fellowship ($2500)
2010 Ian Potter Foundation Travel Grant ($2500)
2010 Keystone Symposia / Barrie Hesp Scholarship (USD$1000)
2008 Australian Diabetes Society Travel Award ($500)
2007 Australian Diabetes Society Travel Award ($1000)
2005 Australian Postgraduate Award (UNSW)
2002 Metabolic Research Centre and UOW Travel Grant
- Fat cells in obesity and breast cancer - fatty acids metabolism as a potential link; Hoy A; DVC Research/Bridging Support Grant.
- Elucidating the Link between Obesity and Prostate Cancer; Hoy A; DVC Research/Bridging Support Fellowship.
- Circulating fat, insulin resistance and obesity; Hoy A; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).