Dr Andrew Hoy
Physiology, School of Medical Sciences
Charles Perkins Centre
|Telephone||02 9351 2514|
Dr Hoy is Head of the Lipid Metabolism Laboratory in the Discipline of Physiology, School of Medical Sciences and Bosch Institute as well as an Honorary Associate with the Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders. He received his PhD training at the Garvan Institute of Medical Research within the Diabetes and Obesity Research Program. Following this he did his Post-Doctoral training at Monash University, as a NHMRC Biomedical Australia training Fellow, which has lead to his current research interest in lipid metabolism and how it is perturbed in Obesity, Diabetes and Cancer.
Research conducted by my laboratory is focused on the regulation of lipid metabolism, predominantly fatty acid storage and utilisation, and how this may be perturbed in chronic disease states such as cancer, obesity and insulin resistance.
Current Laboratory Members:
- Dr Elham Hosseini Behesh - Postdoctoral Fellow
- Miss Seher Balaban - PhD Student
- Miss Quanqing (Helen) Gao - PhD Student; in collaboration with Prof Dai Hibbs and A/Prof Thomas Grewal in the Faculty of Pharmacy
- Mr Harrison Shtein - MPhil Student
- Mr Tim Nguyen - MPhil Student
- Miss Shilpa Nagarajan - MPhil Student
- Mr Griffin Hall - Hons Student
- Miss Meghana Kakani - Hons Student
- Miss Nikki Raftopulos - Hons Student
The Lipid Metabolism Laboratory has two major research themes:
Lipid Metabolism and Insulin Resistance
The accumulation of lipid in tissue sresponsible for regulating blood glucose levels, including skeletal muscle and liver, results in development of insulin resistance. The vast majority of fatty acids are stored in the lipid droplet as triacylglycerols. Hence, the lipid droplet is at the centre of intracellular lipid homeostasis. However, triacylglycerols are not mechanistically linked to the development of insulin resistance. Other lipid species that can arise from lipid processes that occur at the lipid droplet have been proposed to instigate insulin resistance. This theme aims to understand the role of the metabolic processes that occur at the lipid droplet that are altered with insulin resistance.
Lipid Metabolism and Cancer
Metabolic diseases such as obesity and insulin resistance are risk factors for some cancers, as well alter cancer progression. Tumours are characterised by a dramatic shift in their metabolic phenotype, primarily towards non-oxidative metabolism and increased lipid synthesis. That said, the role of fatty acid metabolism in the sustained growth of cancer cells has yet to be fully elucidated. This theme aims to characterise the fatty acid metabolism of cancer cells, how intermediary metabolism and cancer behaviour is altered in an obese microenvironment, and identifying novel metabolic therapeutic target.
Awards and honours
2013 CASS Foundation Travel Grant
2011 Molecular & Cellular Biology of Lipids Gordon Research Conference Junior Scientist Travel Award
2011 Monash Obesity and Diabetes Institute Travel Fellowship
2010 Ian Potter Foundation Travel Grant
2010 Keystone Symposia / Barrie Hesp Scholarship
2008 Australian Diabetes Society Travel Award
2007 Australian Diabetes Society Travel Award
2005 Australian Postgraduate Award (UNSW)
2002 Metabolic Research Centre and UOW Travel Grant
In the media
PhD and master's project opportunities
Honours project opportunities
- Targeting Glutamine metabolism to starve triple-negative breast cancer; Holst J, Beith J, Hoy A, Quek L; University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding.
- Exploiting alterations in lipid metabolism to improve diagnosis, treatment and molecular imaging of prostate cancer; Butler L, Hoy A; Prostate Cancer Foundation of Australia/Translational Prostate Cancer Research Program.
- Linking Cancer Progression to Altered Lipid Metabolism in Obesity; Hoy A; Sydney Medical School/Helen and Robert Ellis Postdoctoral Research Fellowship.
- Fat cells in obesity and breast cancer - fatty acids metabolism as a potential link; Hoy A; DVC Research/Bridging Support Grant.
- Elucidating the Link between Obesity and Prostate Cancer; Hoy A; DVC Research/Bridging Support Fellowship.
- Circulating fat, insulin resistance and obesity; Hoy A; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.