Dr Andrew Hoy

Research Fellow
Physiology, School of Medical Sciences
Bosch Institute

Telephone 02 9351 2514

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Biographical details

Dr Hoy is Head of the Lipid Metabolism Laboratory in the Discipline of Physiology SoMS and Bosch Institute as well as an Honorary Associate position with the Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders. He received his PhD training at the Garvan Institute of Medical Research within the Diabetes and Obesity Research Program. Following this he did his Post-Doctoral training in the laboratory of Prof Matthew Watt at Monash University, as a NHMRC Biomedical Australia training Fellow,which has lead to his current research interest in lipid metabolism and how it is perturbed in Obesity, Diabetes and Cancer.

Dr Hoy is currently an active member of Australian Diabetes Society (since 2006), Australian Physiological Society (since 2001), Australian Society of Medical Research (since 2007), and American Society for Biochemistry and Molecular Biology (since 2011).

Research interests

Research conducted by my laboratory is focused on the regulation of lipid metabolism, predominantly fatty acid storage and utilisation, and how this may be perturbed in chronic disease states such as cancer, obesity and insulin resistance.

Current Laboratory Members:

  • Miss Seher Balaban - PhD Student
  • Mr Harrison Shtein -MPhil Student
  • Mr Tim Nguyen -MPhil Student
  • Miss Lisa Lee - BSc Hons Student

Current projects

The Lipid Metabolism Laboratory has two major research themes:

Lipid Metabolism and Insulin Resistance

The accumulation of lipid in tissue responsible for regulating blood glucose levels, including skeletal muscle and liver, results in the insulin resistance. The vast majority of fatty acids are stored in the lipid droplet as triacylglycerols. Hence, the lipid droplet is at the centre of intracellular lipid homeostasis. However, triacylglycerols are not mechanistically linked to the development of insulin resistance. Other lipid species that can arise from lipid processes that occur at the lipid droplet have been. This theme aims to understand the role of the metabolic processes that occur at the lipid droplet that are altered with insulin resistance.

Lipid Metabolism and Cancer

Metabolic diseases such as obesity and insulin resistance are risk factors for some cancers. Cancer is characterised by a dramatic shift in their metabolic phenotype, primarily towards non-oxidative metabolism and increased lipid synthesis. That said, the role of fatty acid metabolism in the sustained growth of cancer cells has yet to be fully elucidated. This theme aims to characterise the fatty acid metabolism of cancer cells and its role as a therapeutic target.

Awards and honours

2013 CASS Foundation Travel Grant ($3000)

2011 Molecular & Cellular Biology of Lipids Gordon Research Conference Junior Scientist Travel Award (USD$500)

2011 Monash Obesity and Diabetes Institute Travel Fellowship ($2500)

2010 Ian Potter Foundation Travel Grant ($2500)

2010 Keystone Symposia / Barrie Hesp Scholarship (USD$1000)

2008 Australian Diabetes Society Travel Award ($500)

2007 Australian Diabetes Society Travel Award ($1000)

2005 Australian Postgraduate Award (UNSW)

2002 Metabolic Research Centre and UOW Travel Grant

Selected grants

2015

  • Linking Cancer Progression to Altered Lipid Metabolism in Obesity; Hoy A; Sydney Medical School/Helen and Robert Ellis Postdoctoral Research Fellowship.

2014

  • Fat cells in obesity and breast cancer - fatty acids metabolism as a potential link; Hoy A; DVC Research/Bridging Support Grant.
  • Elucidating the Link between Obesity and Prostate Cancer; Hoy A; DVC Research/Bridging Support Fellowship.

2012

  • Circulating fat, insulin resistance and obesity; Hoy A; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Journals

  • Briggs, D., Lockie, S., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., Hoy, A., Lemus, M., Coleman, H., Parkington, H., et al (2014). Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice. Endocrinology, 155(7), 2411-2422. [More Information]
  • Abboud, M., Gordon-Thomson, C., Hoy, A., Balaban, S., Rybchyn, M., Cole, L., Su, Y., Brennan-Speranza, T., Fraser, D., Mason, R. (2014). Uptake of 25-Hydroxyvitamin D by muscle and fat cells. Journal of Steroid Biochemistry and Molecular Biology, 144(Part A), 232-236. [More Information]
  • Peoples, G., Hoy, A., Henry, R., McLennan, P. (2013). Autologous pump-perfused rat hind limb preparation for investigating muscle function and metabolism in vivo. Microcirculation, 20(6), 511-523. [More Information]
  • Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Watt, M., Hoy, A., Muoio, D., Coleman, R. (2012). Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. American Journal of Physiology: Endocrinology and Metabolism (online), 302, E1-E3. [More Information]
  • Watt, M., Hoy, A. (2012). Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function. American Journal of Physiology: Endocrinology and Metabolism (online), 302(11), e1315-e1328. [More Information]
  • Watt, M., Barnett, A., Bruce, C., Schenk, S., Horowitz, J., Hoy, A. (2012). Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. Diabetologia, 55(10), 2741-2746. [More Information]
  • Turpin, S., Hoy, A., Brown, R., Rudaz, C., Honeyman, J., Matzaris, M., Watt, M. (2011). Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia, 54(1), 146-156. [More Information]
  • Hoy, A., Bruce, C., Turpin, S., Morris, A., Febbraio, M., Watt, M. (2011). Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology, 152(1), 48-58. [More Information]
  • Wright, L., Brandon, A., Hoy, A., Forsberg, G., Lelliott, C., Reznick, J., Löfgren, L., Oscarsson, J., Strömstedt, M., Cooney, G., et al (2011). Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1(beta) involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia, 54(6), 1417-1426. [More Information]
  • Hoy, A., Brandon, A., Turner, N., Watt, M., Bruce, C., Cooney, G., Kraegen, E. (2009). Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism, 297(1), E67-E75. [More Information]
  • Hoy, A., Watt, M. (2009). Lipid Partitioning and Insulin Sensitivity: Lessons learntfrom Genetic Models. Asia-Pacific Journal of Endocrinology (APJOE), 1(1), 35-47.
  • Hoy, A., Peoples, G., McLennan, P. (2009). The effect of vasoconstrictors on oxygen consumption in resting and contracting skeletal muscle of the autologous pump-perfused rat hindlimb. Journal of Physiology and Pharmacology, 60(3), 155-160. [More Information]
  • Hoy, A., Turner, N. (2008). New insight into the mechanism by which acute physical exercise ameliorates insulin resistance. The Journal of Physiology, 586(9), 2251-2252. [More Information]
  • Hoy, A., Bruce, C., Cederberg, A., Turner, N., James, D., Cooney, G., Kraegen, E. (2007). Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism, 293(5), e1358-e1364. [More Information]
  • Kraegen, E., Saha, A., Preston, E., Wilks, D., Hoy, A., Cooney, G., Ruderman, N. (2006). Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology: Endocrinology and Metabolism, 290, e471-e479. [More Information]
  • Ye, J., Dzamko, N., Hoy, A., Iglesias, M., Kemp, B., Kraegen, E. (2006). Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats. Diabetes, 55(10), 2797-2804. [More Information]

2014

  • Briggs, D., Lockie, S., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., Hoy, A., Lemus, M., Coleman, H., Parkington, H., et al (2014). Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice. Endocrinology, 155(7), 2411-2422. [More Information]
  • Abboud, M., Gordon-Thomson, C., Hoy, A., Balaban, S., Rybchyn, M., Cole, L., Su, Y., Brennan-Speranza, T., Fraser, D., Mason, R. (2014). Uptake of 25-Hydroxyvitamin D by muscle and fat cells. Journal of Steroid Biochemistry and Molecular Biology, 144(Part A), 232-236. [More Information]

2013

  • Peoples, G., Hoy, A., Henry, R., McLennan, P. (2013). Autologous pump-perfused rat hind limb preparation for investigating muscle function and metabolism in vivo. Microcirculation, 20(6), 511-523. [More Information]
  • Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]

2012

  • Watt, M., Hoy, A., Muoio, D., Coleman, R. (2012). Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. American Journal of Physiology: Endocrinology and Metabolism (online), 302, E1-E3. [More Information]
  • Watt, M., Hoy, A. (2012). Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function. American Journal of Physiology: Endocrinology and Metabolism (online), 302(11), e1315-e1328. [More Information]
  • Watt, M., Barnett, A., Bruce, C., Schenk, S., Horowitz, J., Hoy, A. (2012). Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. Diabetologia, 55(10), 2741-2746. [More Information]

2011

  • Turpin, S., Hoy, A., Brown, R., Rudaz, C., Honeyman, J., Matzaris, M., Watt, M. (2011). Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia, 54(1), 146-156. [More Information]
  • Hoy, A., Bruce, C., Turpin, S., Morris, A., Febbraio, M., Watt, M. (2011). Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology, 152(1), 48-58. [More Information]
  • Wright, L., Brandon, A., Hoy, A., Forsberg, G., Lelliott, C., Reznick, J., Löfgren, L., Oscarsson, J., Strömstedt, M., Cooney, G., et al (2011). Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1(beta) involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia, 54(6), 1417-1426. [More Information]

2009

  • Hoy, A., Brandon, A., Turner, N., Watt, M., Bruce, C., Cooney, G., Kraegen, E. (2009). Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism, 297(1), E67-E75. [More Information]
  • Hoy, A., Watt, M. (2009). Lipid Partitioning and Insulin Sensitivity: Lessons learntfrom Genetic Models. Asia-Pacific Journal of Endocrinology (APJOE), 1(1), 35-47.
  • Hoy, A., Peoples, G., McLennan, P. (2009). The effect of vasoconstrictors on oxygen consumption in resting and contracting skeletal muscle of the autologous pump-perfused rat hindlimb. Journal of Physiology and Pharmacology, 60(3), 155-160. [More Information]

2008

  • Hoy, A., Turner, N. (2008). New insight into the mechanism by which acute physical exercise ameliorates insulin resistance. The Journal of Physiology, 586(9), 2251-2252. [More Information]

2007

  • Hoy, A., Bruce, C., Cederberg, A., Turner, N., James, D., Cooney, G., Kraegen, E. (2007). Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism, 293(5), e1358-e1364. [More Information]

2006

  • Kraegen, E., Saha, A., Preston, E., Wilks, D., Hoy, A., Cooney, G., Ruderman, N. (2006). Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology: Endocrinology and Metabolism, 290, e471-e479. [More Information]
  • Ye, J., Dzamko, N., Hoy, A., Iglesias, M., Kemp, B., Kraegen, E. (2006). Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats. Diabetes, 55(10), 2797-2804. [More Information]

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