Dr Anthony Ashton

Level C (Research Only) Academic
Obstetrics, Gynaecology and Neonatology, Northern Clinical School
anthony.ashton@sydney.edu.au

Telephone +61 2 9926 8486
Fax +61 2 9926 8484
Website Linked In

Map

Research interests

  • Role of Alternate Splicing as a regulator of Human Disease
  • Angiogenesis and its modulation with age and in asthmatic airway remodelling
  • Cardiac Ischemia reperfusion and heart failure
  • Placentation and pathologies of pregnancy
  • Cancer initiation and the Stromal Response to Cancer
  • Role of small non-protein based mediators in the pathophysiology of disease
  • The role of eicosanoids in the host-parasite relationship in Chagas disease
  • Role of cell death processes, and the shared pathogenesis of, osteoarthritis and heart failure

Our research program seeks to understand the role of alternate splicing (and the structurally diverse proteins it creates) in the pathogenesis of disease. Due to the essential nature of these changes we have found applications for this research in a wide variety of maladies including cancer, cardiovascular disease, reproduction, asthma and ageing. Our program employs techniques from recombinant protein production to cell culture and in vivo models to assess the roles of these proteins and how changes in splicing manifest disease.

Current research students

Project title Research student
Working towards a new therapy for the prevention of impaired fetal growth. Gaayathri ARIYAKUMAR

Keywords

angiogenesis; eicosanoids; chemotaxis; Reperfusion injury; apoptosis

Clinical Specialty

Obstetrics and Gynaecology

International links

Ireland

(Department of Biochemistry, Conway Institute of Biomolecular & Biomedical Research, University College, Dublin) Structure-function relationships in prostaglandin receptors Dr. B. Therese Kinsella

Italy

(Lab. of Molecular Pharmacology Dept. Pharmacological Sciences University of Milan) Examining structural motifs in the regulation of thromboxane receptor signalling Dr.s Valerie Capra and G.Enrico Rovati

United States

(Albert Einstein College of Medicine) Consultant to Mechanisms of Disease Training Grant Dr.s Weiss and Tanowitz

United States

(Center for Arrhythmia Research University of Michigan Ann Arbour, MI) Role of connexin 43 in angiogenesis Dr. Mario Delmar

United States

(Department of Medicine; Division of Nephrology Duke University Medical Center Durham, NC) Role in TP in disease Dr. Thomas Coffman

United States

(Department of Molecular Physiology and Biological Physics University of Virginia School of Medicine) Study of the pathophysiological role of connexins in angiogenesis Dr. Brian Duling

United States

(Department of Pathology Montefiore Medical Center Albert Einstein College of Medicine) Dissecting the mechanisms of anti-phospholipid antibodies in coagulation Dr. Jacob Rand

United States

(Dept.s of Radiation Oncology & Pathology Wayne State University Detroit, MI) Study of the pathophysiological role of thromboxane receptors Dr. Kenneth V. Honn

United States

(Institute of Translational Medicine and Therapeutics University of Pennsylvania School of Medicine) Examining the regulation of angiogenesis by thromboxane receptors in vivo Dr.s Garret FitzGerald and Yan Cheng

United States

(University of Kentucky) Study of thromboxane receptor signalling Dr. Hsin-Hsiung Tai

United States

(University of Texas Health Centre) Study of the pathogenic role of TXA2 in cancer and parasitic disease Dr. Kenneth Wu

Selected grants

2017

  • Thromboxane Receptors Linking Oxidative Stress to Poor Pacentation; Ashton A; DVC Research/Bridging Support Grant.

2016

  • ARC, a newly identified regulator of chondrocyte differentiation and death, is a novel therapeutic target for OA; Little C, Ashton A, Bateman J; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • BD Fortessa Flow Cytometer; Morris J, Little C, Baxter R, Ward C, Ashton A; DVC Research/Equipment Grant.

2014

  • The central role of Connective Tissue Growth Factor in remodelling of asthmatic airways; Ashton A, Burgess J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Role for the human-specific isoform of the thromboxane A2 receptor (TPB) in the pathogenesis of pre-eclampsia and the cardiovascular complications of pregnancy; Ashton A, Morris J; Heart Research Australia./Research Support.
  • Gap junctions in angiogenesis; Ashton A; DVC Research/Bridging Support Grant.
  • Working towards a new therapy for IUGR; Morris J, McCracken S, Ashton A; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Bridging Support for Senior Scientists - Northern Clinical School; Ashton A; Northern Sydney and Central Coast Area Health Service/Research Support.

2012

  • Regulation of Tumour Development by the Thromboxane A2 Receptor Signalling Axis.; Ashton A; DVC Research/Bridging Support Fellowship.

2011

  • IncuCyte FLR Microscope System and Cell Incubator; Baxter R, Marsh D, Jackson C, O'Neill C, Ashton A, Howell V; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2010

  • Population Health at the Clinical Interface: Pregnancy and Childbirth; Haines M, Roberts C, Ford J, Todd A, Simpson J, Ashton A, Taylor L, Morris J, Ellwood D; National Health and Medical Research Council (NHMRC)/Centres of Clinical Research Excellence.
  • Role of the B-Isoform of the thromboxane A2 receptor in breast cancer; Ashton A, Marsh D; North Sydney Central Coast Area Health Services (NSCCAH)/Research Support.
  • In-Vivo Multispectral Imaging FX System: small animal imaging for multi-modal molecular signal localisation in live animals; Marsh D, Baxter R, Ashton A, Howell V, Soon P, Little D, Robinson B; Cancer Institute New South Wales/Equipment Grant.

2009

  • Connexin Isoform Switching Regulates Angiogenesis; Ashton A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of oxygen sensing in regulation of trophoblast invasion; Morris J, Gallery E, Ashton A; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Thromboxane receptor signalling in endothelial cells; Ashton A; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Regulation Of Angiogenesis By Thromboxane Receptor Activation; Ashton A; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Mihailidou, A., Ritchie, R., Ashton, A. (2013). Sex Differences in Sudden Cardiac Death. In David Gaze (Eds.), Ischemic Heart Disease, (pp. 61-75). Croatia: InTech Publishers. [More Information]
  • Machado, F., Mukherjee, S., Weiss, L., Tanowitz, H., Ashton, A. (2011). Bioactive Lipids in Trypanosoma cruzi Infection. In Louis M. Weiss and Herbert B. Tanowitz (Eds.), Advances in Parasitology (Volume 76): Chagas Disease, Part B, (pp. 1-31). London: Academic Press. [More Information]
  • Ashton, A., D'Alessandro, D., Michler, E. (2006). Use of skeletal myoblasts for the treatment of CHF. In Marc S Penn (Eds.), Stem Cells and Myocardial, (pp. 259-276). United States: Humana Press. [More Information]
  • Ashton, A., Duffy, H., Iacobas, I., Spray, D. (2005). Using antibody arrays to detect protein-protein interactions in connexins. In Stefan Dhein, Friedrich Wilhelm Mohr & Mario Delmar (Eds.), Practical Methods in Cardiovascular Research, (pp. 916-935). United States of America: Springer.

Journals

  • McKelvey, K., Yenson, V., Ashton, A., Morris, J., McCracken, S. (2016). Embryonic/fetal mortality and intrauterine growth restriction is not exclusive to the CBA/J sub-strain in the CBA � DBA model. Scientific Reports, 6, 1-11. [More Information]
  • Powell, K., Stevens, V., Upton, D., McCracken, S., Simpson, A., Cheng, Y., Tasevski, V., Morris, J., Ashton, A. (2016). Role for the thromboxane A2 receptor (beta)-isoform in the pathogenesis of intrauterine growth restriction. Scientific Reports, 6, 1-15. [More Information]
  • Harkness, L., Ashton, A., Burgess, J. (2015). Asthma is not only an airway disease, but also a vascular disease. Pharmacology & Therapeutics, 148(C), 17-33. [More Information]
  • Schneuer, F., Nassar, N., Guilbert, C., Tasevski, V., Ashton, A., Morris, J., Roberts, C. (2015). Evaluation of first trimester serum soluble endothelial cell-specific tyrosine kinase receptor in normal and affected pregnancies. The Journal of Maternal-Fetal & Neonatal Medicine, 28(15), 1815-1821. [More Information]
  • McKelvey, K., Powell, K., Ashton, A., Morris, J., McCracken, S. (2015). Exosomes: Mechanisms of Uptake. Journal of Circulating Biomarkers, 4(7), 1-9. [More Information]
  • Morton, S., Chaston, D., Howitt, L., Heisler, J., Nicholson, B., Fairweather, S., Broer, S., Ashton, A., Matthaei, K., Hill, C. (2015). Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice. Hypertension, 65(3), 662-669. [More Information]
  • Ashton, A., Le, T., Gomez-Sanchez, C., Morel-Kopp, M., McWhitney, B., Hudson, A., Mihailidou, A. (2015). Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury. Molecular Endocrinology, 29(8), 1144-1155. [More Information]
  • Mukherjee, S., Mukhopadhyay, A., Andriani, G., Machado, F., Ashton, A., Huang, H., Weiss, L., Tanowitz, H. (2015). Trypanosoma cruzi invasion is associated with trogocytosis. Microbes and Infection, 17, 62-70. [More Information]
  • Schneuer, F., Roberts, C., Ashton, A., Guilbert, C., Tasevski, V., Morris, J., Nassar, N. (2014). Angiopoietin 1 and 2 serum concentrations in first trimester of pregnancy as biomarkers of adverse pregnancy outcomes. American Journal of Obstetrics & Gynecology, 210(4), 345 e1-345 e9. [More Information]
  • Mihailidou, A., Ashton, A. (2014). Cardiac effects of aldosterone: Does gender matter? Steroids, 91(C), 32-37. [More Information]
  • Schneuer, F., Roberts, C., Guilbert, C., Simpson, J., Algert, C., Khambalia, A., Tasevski, V., Ashton, A., Morris, J., Nassar, N. (2014). Effects of maternal serum 25-hydroxyvitamin D concentrations in the first trimester on subsequent pregnancy outcomes in an Australian population. American Journal of Clinical Nutrition, 99(2), 287-295. [More Information]
  • Le, T., Ashton, A., Mardini, M., Stanton, P., Funder, J., Handelsman, D., Mihailidou, A. (2014). Role of Androgens in Sex Differences in Cardiac Damage During Myocardial Infarction. Endocrinology, 155(2), 568-575. [More Information]
  • Schneuer, F., Nassar, N., Guilbert, C., Tasevski, V., Ashton, A., Morris, J., Roberts, C. (2013). First trimester screening of serum soluble fms-like tyrosine kinase-1 and placental growth factor predicting hypertensive disorders of pregnancy. Pregnancy Hypertension: an international journal of women's cardiovascular health, 3(4), 215-221. [More Information]
  • Mukherjee, S., Sadekar, N., Ashton, A., Huang, H., Spray, D., Lisanti, M., Machado, F., Weiss, L., Tanowitz, H. (2013). Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi. Parasitology Research, 112(4), 1417-1425. [More Information]
  • Chaston, D., Baillie, B., Grayson, T., Courjaret, R., Heisler, J., Lau, K., Machaca, K., Nicholson, B., Ashton, A., Matthaei, K., et al (2013). Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(5), 962-970. [More Information]
  • Schneuer, F., Nassar, N., Khambalia, A., Tasevski, V., Ashton, A., Morris, J., Roberts, C. (2012). First trimester screening of maternal placental protein 13 for predicting preeclampsia and small for gestational age: In-house study and systematic review. Placenta, 33(9), 735-740. [More Information]
  • Le, T., Mardini, M., Howell, V., Funder, J., Ashton, A., Mihailidou, A. (2012). Low-dose spironolactone prevents apoptosis repressor with caspase recruitment domain degradation during myocardial infarction. Hypertension, 59(6), 1164-1169. [More Information]
  • Woolnough, C., Wang, Y., Kan, C., Morris, J., Tasevski, V., Ashton, A. (2012). Source of angiopoietin-2 in the sera of women during pregnancy. Microvascular research, 84(3), 367-374. [More Information]
  • Gavrilov, S., Nuhrenberg, T., Ashton, A., Peng, C., Moore, J., Konstantinidis, K., Mummery, C., Kitsis, R. (2012). Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells. Differentiation, 84(2), 176-184. [More Information]
  • Mukherjee, S., Machado, F., Huang, H., Oz, H., Jelicks, L., Prado, C., Koba, W., Fine, E., Zhao, D., Factor, S., Ashton, A., et al (2011). Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. PloS One, 6(2), e16959-1-e16959-10. [More Information]
  • Jacobs, M., Nassar, N., Roberts, C., Hadfield, R., Morris, J., Ashton, A. (2011). Levels of soluble fms-like tyrosine kinase one in first trimester and outcomes of pregnancy: a systematic review. Reproductive Biology and Endocrinology, 9(June), 77-1-77-8. [More Information]
  • Tanowitz, H., Mukhopadhyay, A., Ashton, A., Lisanti, M., Machado, F., Weiss, L., Mukherjee, S. (2011). Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction. Cell Cycle, 10(7), 1132-1143. [More Information]
  • Hadfield, K., McCracken, S., Ashton, A., Nguyen, T., Morris, J. (2011). Regulated suppression of NF-kB throughout pregnancy maintains a favourable cytokine environment necessary for pregnancy success. Journal of Reproductive Immunology, 89(1), 1-9. [More Information]
  • Nassar, N., Halligan, G., Roberts, C., Morris, J., Ashton, A. (2011). Systematic review of first-trimester vitamin D normative levels and outcomes of pregnancy. American Journal of Obstetrics & Gynecology, 205(3), 208.e1-208.e7. [More Information]
  • Ekambaram, P., Lambiv, W., Cazzolli, R., Ashton, A., Honn, K. (2011). The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis. Cancer and Metastasis Reviews, 30(3-4), 397-408. [More Information]
  • Rand, J., Wu, X., Quinn, A., Ashton, A., Chen, P., Hathcock, J., Andree, H., Taatjes, D. (2010). Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug. Blood, 115(11), 2292-2299. [More Information]
  • Villalta, F., Scharfstein, J., Ashton, A., Tyler, K., Guan, F., Mukherjee, S., Lima, M., Alvarez, S., Weiss, L., Huang, H., et al (2009). Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitology Research, 104(6), 1251-1260. [More Information]
  • Moussa, O., Ashton, A., Fraig, M., Garrett-Mayer, E., Ghoneim, M., Halushka, P., Watson, D. (2008). Novel Role of Thromboxane Receptors β Isoform in Bladder Cancer Pathogenesis. Cancer Research, 68(11), 4097-4104. [More Information]
  • Muehlbauer, S., Evering, T., Bonuccelli, G., Squires, R., Ashton, A., Porcelli, S., Lisanti, M., Brojatsch, J., Brojatsch, J. (2007). Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis. Cell Cycle, 6(6), 758-766. [More Information]
  • Zembala, M., Wilczek, P., Kwiatkowski, P., Ashton, A. (2007). Myocardial regeneration – the revolution continues. Kardiochirurgia i Torakochirurgia Polska, 4(3), 239-245.
  • Foo, R., Nam, Y., Ostreicher, M., Metzl, M., Whelan, R., Peng, C., Ashton, A., Fu, W., Mani, K., Chin, S., et al (2007). Regulation of p53 tetramerization and nuclear export by ARC. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 104(52), 20826-20831. [More Information]
  • Nam, Y., Mani, K., Wu, L., Peng, C., Calvert, J., Foo, R., Krishnamurthy, B., Miao, W., Ashton, A., Lefer, D., et al (2007). The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. Journal of Biological Chemistry, 282(8), 5522-5528. [More Information]
  • Ashton, A., Mukherjee, S., Nagajyothi, F., Huang, H., Braunstein, V., Desruisseaux, M., Factor, S., Lopez, L., Berman, J., Wittner, M., et al (2007). Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. The Journal of Experimental Medicine, 204(4), 929-940. [More Information]
  • Mercier, I., Vuolo, M., Madan, R., Xue, X., Levalley, A., Ashton, A., Jasmin, J., Czaja, M., Lin, E., Armstrong, R., et al (2005). ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance. Cell Death and Differentiation, 12(6), 682-686. [More Information]
  • Colombo, P., Banchs, J., Celaj, S., Talreja, A., Lachmann, J., Malla, S., DuBois, N., Ashton, A., Latif, F., Jorde, U., et al (2005). Endothelial cell activation in patients with decompensated heart failure. Circulation, 111(1), 58-62. [More Information]
  • Nam, Y., Mani, K., Ashton, A., Peng, C., Krishnamurthy, B., Hayakawa, Y., Lee, P., Korsmeyer, S., Kitsis, R. (2004). Inhibition of Both the Extrinsic and Intrinsic Death Pathways through Nonhomotypic Death-Fold Interactions. Molecular Cell, 15(6), 901-912. [More Information]
  • Duffy, H., Ashton, A., O'Donnell, P., Coombs, W., Taffet, S., Delmar, M., Spray, D. (2004). Regulation of connexin43 protein complexes by intracellular acidification. Circulation Research, 94(2), 215-222. [More Information]
  • Ashton, A., Cheng, Y., Helisch, A., Ware, J. (2004). Thromboxane A2 Receptor Agonists Antagonize the Proangiogenic Effects of Fibroblast Growth Factor-2:Role of Receptor Internalization, Thrombospondin-1, and αvβ3. Circulation Research, 94(6), 735-742. [More Information]
  • Ashton, A., Ware, J. (2004). Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration. Circulation Research, 95(4), 372-379. [More Information]
  • Woodman, S., Ashton, A., Schubert, W., Lee, H., Williams, T., Medina, F., Wyckoff, J., Combs, T., Lisanti, M. (2003). Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli. The American Journal of Pathology, 162(6), 2059-2068. [More Information]
  • Neumeister, P., Pixley, F., Xiong, Y., Xie, H., Wu, K., Ashton, A., Cammer, M., Chan, A., Symons, M., Stanley, E., et al (2003). Cyclin D1 governs adhesion and motility of macrophages. Molecular Biology of the Cell, 14(5), 2005-2015. [More Information]
  • Ashton, A., Ware, G., Kaul, D., Ware, J. (2003). Inhibition of tumor necrosis factor alpha-mediated NFkappaB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) ligands. Journal of Biological Chemistry, 278(14), 11858-11866. [More Information]
  • Hotchkiss, K., Ashton, A., Klein, R., Lenzi, M., Zhu, G., Schwartz, E. (2003). Mechanisms by Which Tumor Cells and Monocytes Expressing the Angiogenic Factor Thymidine Phosphorylase Mediate Human Endothelial Cell Migration. Cancer Research, 63(2), 527-533. [More Information]
  • Ma, H., Calderon, T., Kessel, T., Ashton, A., Berman, J. (2003). Mechanisms of hepatocyte growth factor-mediated vascular smooth muscle cell migration. Circulation Research, 93(11), 1066-1073. [More Information]
  • Hotchkiss, K., Ashton, A., Schwartz, E. (2003). Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3. Journal of Biological Chemistry, 278(21), 19272-19279. [More Information]
  • Mani, K., Ashton, A., Kitsis, R. (2002). Taking the BAD out of Adrenergic Stimulation. Journal of Molecular and Cellular Cardiology, 34, 709-712.

2016

  • McKelvey, K., Yenson, V., Ashton, A., Morris, J., McCracken, S. (2016). Embryonic/fetal mortality and intrauterine growth restriction is not exclusive to the CBA/J sub-strain in the CBA � DBA model. Scientific Reports, 6, 1-11. [More Information]
  • Powell, K., Stevens, V., Upton, D., McCracken, S., Simpson, A., Cheng, Y., Tasevski, V., Morris, J., Ashton, A. (2016). Role for the thromboxane A2 receptor (beta)-isoform in the pathogenesis of intrauterine growth restriction. Scientific Reports, 6, 1-15. [More Information]

2015

  • Harkness, L., Ashton, A., Burgess, J. (2015). Asthma is not only an airway disease, but also a vascular disease. Pharmacology & Therapeutics, 148(C), 17-33. [More Information]
  • Schneuer, F., Nassar, N., Guilbert, C., Tasevski, V., Ashton, A., Morris, J., Roberts, C. (2015). Evaluation of first trimester serum soluble endothelial cell-specific tyrosine kinase receptor in normal and affected pregnancies. The Journal of Maternal-Fetal & Neonatal Medicine, 28(15), 1815-1821. [More Information]
  • McKelvey, K., Powell, K., Ashton, A., Morris, J., McCracken, S. (2015). Exosomes: Mechanisms of Uptake. Journal of Circulating Biomarkers, 4(7), 1-9. [More Information]
  • Morton, S., Chaston, D., Howitt, L., Heisler, J., Nicholson, B., Fairweather, S., Broer, S., Ashton, A., Matthaei, K., Hill, C. (2015). Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice. Hypertension, 65(3), 662-669. [More Information]
  • Ashton, A., Le, T., Gomez-Sanchez, C., Morel-Kopp, M., McWhitney, B., Hudson, A., Mihailidou, A. (2015). Role of Nongenomic Signaling Pathways Activated by Aldosterone During Cardiac Reperfusion Injury. Molecular Endocrinology, 29(8), 1144-1155. [More Information]
  • Mukherjee, S., Mukhopadhyay, A., Andriani, G., Machado, F., Ashton, A., Huang, H., Weiss, L., Tanowitz, H. (2015). Trypanosoma cruzi invasion is associated with trogocytosis. Microbes and Infection, 17, 62-70. [More Information]

2014

  • Schneuer, F., Roberts, C., Ashton, A., Guilbert, C., Tasevski, V., Morris, J., Nassar, N. (2014). Angiopoietin 1 and 2 serum concentrations in first trimester of pregnancy as biomarkers of adverse pregnancy outcomes. American Journal of Obstetrics & Gynecology, 210(4), 345 e1-345 e9. [More Information]
  • Mihailidou, A., Ashton, A. (2014). Cardiac effects of aldosterone: Does gender matter? Steroids, 91(C), 32-37. [More Information]
  • Schneuer, F., Roberts, C., Guilbert, C., Simpson, J., Algert, C., Khambalia, A., Tasevski, V., Ashton, A., Morris, J., Nassar, N. (2014). Effects of maternal serum 25-hydroxyvitamin D concentrations in the first trimester on subsequent pregnancy outcomes in an Australian population. American Journal of Clinical Nutrition, 99(2), 287-295. [More Information]
  • Le, T., Ashton, A., Mardini, M., Stanton, P., Funder, J., Handelsman, D., Mihailidou, A. (2014). Role of Androgens in Sex Differences in Cardiac Damage During Myocardial Infarction. Endocrinology, 155(2), 568-575. [More Information]

2013

  • Schneuer, F., Nassar, N., Guilbert, C., Tasevski, V., Ashton, A., Morris, J., Roberts, C. (2013). First trimester screening of serum soluble fms-like tyrosine kinase-1 and placental growth factor predicting hypertensive disorders of pregnancy. Pregnancy Hypertension: an international journal of women's cardiovascular health, 3(4), 215-221. [More Information]
  • Mukherjee, S., Sadekar, N., Ashton, A., Huang, H., Spray, D., Lisanti, M., Machado, F., Weiss, L., Tanowitz, H. (2013). Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi. Parasitology Research, 112(4), 1417-1425. [More Information]
  • Chaston, D., Baillie, B., Grayson, T., Courjaret, R., Heisler, J., Lau, K., Machaca, K., Nicholson, B., Ashton, A., Matthaei, K., et al (2013). Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(5), 962-970. [More Information]
  • Mihailidou, A., Ritchie, R., Ashton, A. (2013). Sex Differences in Sudden Cardiac Death. In David Gaze (Eds.), Ischemic Heart Disease, (pp. 61-75). Croatia: InTech Publishers. [More Information]

2012

  • Schneuer, F., Nassar, N., Khambalia, A., Tasevski, V., Ashton, A., Morris, J., Roberts, C. (2012). First trimester screening of maternal placental protein 13 for predicting preeclampsia and small for gestational age: In-house study and systematic review. Placenta, 33(9), 735-740. [More Information]
  • Le, T., Mardini, M., Howell, V., Funder, J., Ashton, A., Mihailidou, A. (2012). Low-dose spironolactone prevents apoptosis repressor with caspase recruitment domain degradation during myocardial infarction. Hypertension, 59(6), 1164-1169. [More Information]
  • Woolnough, C., Wang, Y., Kan, C., Morris, J., Tasevski, V., Ashton, A. (2012). Source of angiopoietin-2 in the sera of women during pregnancy. Microvascular research, 84(3), 367-374. [More Information]
  • Gavrilov, S., Nuhrenberg, T., Ashton, A., Peng, C., Moore, J., Konstantinidis, K., Mummery, C., Kitsis, R. (2012). Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells. Differentiation, 84(2), 176-184. [More Information]

2011

  • Mukherjee, S., Machado, F., Huang, H., Oz, H., Jelicks, L., Prado, C., Koba, W., Fine, E., Zhao, D., Factor, S., Ashton, A., et al (2011). Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. PloS One, 6(2), e16959-1-e16959-10. [More Information]
  • Machado, F., Mukherjee, S., Weiss, L., Tanowitz, H., Ashton, A. (2011). Bioactive Lipids in Trypanosoma cruzi Infection. In Louis M. Weiss and Herbert B. Tanowitz (Eds.), Advances in Parasitology (Volume 76): Chagas Disease, Part B, (pp. 1-31). London: Academic Press. [More Information]
  • Jacobs, M., Nassar, N., Roberts, C., Hadfield, R., Morris, J., Ashton, A. (2011). Levels of soluble fms-like tyrosine kinase one in first trimester and outcomes of pregnancy: a systematic review. Reproductive Biology and Endocrinology, 9(June), 77-1-77-8. [More Information]
  • Tanowitz, H., Mukhopadhyay, A., Ashton, A., Lisanti, M., Machado, F., Weiss, L., Mukherjee, S. (2011). Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction. Cell Cycle, 10(7), 1132-1143. [More Information]
  • Hadfield, K., McCracken, S., Ashton, A., Nguyen, T., Morris, J. (2011). Regulated suppression of NF-kB throughout pregnancy maintains a favourable cytokine environment necessary for pregnancy success. Journal of Reproductive Immunology, 89(1), 1-9. [More Information]
  • Nassar, N., Halligan, G., Roberts, C., Morris, J., Ashton, A. (2011). Systematic review of first-trimester vitamin D normative levels and outcomes of pregnancy. American Journal of Obstetrics & Gynecology, 205(3), 208.e1-208.e7. [More Information]
  • Ekambaram, P., Lambiv, W., Cazzolli, R., Ashton, A., Honn, K. (2011). The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis. Cancer and Metastasis Reviews, 30(3-4), 397-408. [More Information]

2010

  • Rand, J., Wu, X., Quinn, A., Ashton, A., Chen, P., Hathcock, J., Andree, H., Taatjes, D. (2010). Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug. Blood, 115(11), 2292-2299. [More Information]

2009

  • Villalta, F., Scharfstein, J., Ashton, A., Tyler, K., Guan, F., Mukherjee, S., Lima, M., Alvarez, S., Weiss, L., Huang, H., et al (2009). Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitology Research, 104(6), 1251-1260. [More Information]

2008

  • Moussa, O., Ashton, A., Fraig, M., Garrett-Mayer, E., Ghoneim, M., Halushka, P., Watson, D. (2008). Novel Role of Thromboxane Receptors β Isoform in Bladder Cancer Pathogenesis. Cancer Research, 68(11), 4097-4104. [More Information]

2007

  • Muehlbauer, S., Evering, T., Bonuccelli, G., Squires, R., Ashton, A., Porcelli, S., Lisanti, M., Brojatsch, J., Brojatsch, J. (2007). Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis. Cell Cycle, 6(6), 758-766. [More Information]
  • Zembala, M., Wilczek, P., Kwiatkowski, P., Ashton, A. (2007). Myocardial regeneration – the revolution continues. Kardiochirurgia i Torakochirurgia Polska, 4(3), 239-245.
  • Foo, R., Nam, Y., Ostreicher, M., Metzl, M., Whelan, R., Peng, C., Ashton, A., Fu, W., Mani, K., Chin, S., et al (2007). Regulation of p53 tetramerization and nuclear export by ARC. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 104(52), 20826-20831. [More Information]
  • Nam, Y., Mani, K., Wu, L., Peng, C., Calvert, J., Foo, R., Krishnamurthy, B., Miao, W., Ashton, A., Lefer, D., et al (2007). The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant. Journal of Biological Chemistry, 282(8), 5522-5528. [More Information]
  • Ashton, A., Mukherjee, S., Nagajyothi, F., Huang, H., Braunstein, V., Desruisseaux, M., Factor, S., Lopez, L., Berman, J., Wittner, M., et al (2007). Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. The Journal of Experimental Medicine, 204(4), 929-940. [More Information]

2006

  • Ashton, A., D'Alessandro, D., Michler, E. (2006). Use of skeletal myoblasts for the treatment of CHF. In Marc S Penn (Eds.), Stem Cells and Myocardial, (pp. 259-276). United States: Humana Press. [More Information]

2005

  • Mercier, I., Vuolo, M., Madan, R., Xue, X., Levalley, A., Ashton, A., Jasmin, J., Czaja, M., Lin, E., Armstrong, R., et al (2005). ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance. Cell Death and Differentiation, 12(6), 682-686. [More Information]
  • Colombo, P., Banchs, J., Celaj, S., Talreja, A., Lachmann, J., Malla, S., DuBois, N., Ashton, A., Latif, F., Jorde, U., et al (2005). Endothelial cell activation in patients with decompensated heart failure. Circulation, 111(1), 58-62. [More Information]
  • Ashton, A., Duffy, H., Iacobas, I., Spray, D. (2005). Using antibody arrays to detect protein-protein interactions in connexins. In Stefan Dhein, Friedrich Wilhelm Mohr & Mario Delmar (Eds.), Practical Methods in Cardiovascular Research, (pp. 916-935). United States of America: Springer.

2004

  • Nam, Y., Mani, K., Ashton, A., Peng, C., Krishnamurthy, B., Hayakawa, Y., Lee, P., Korsmeyer, S., Kitsis, R. (2004). Inhibition of Both the Extrinsic and Intrinsic Death Pathways through Nonhomotypic Death-Fold Interactions. Molecular Cell, 15(6), 901-912. [More Information]
  • Duffy, H., Ashton, A., O'Donnell, P., Coombs, W., Taffet, S., Delmar, M., Spray, D. (2004). Regulation of connexin43 protein complexes by intracellular acidification. Circulation Research, 94(2), 215-222. [More Information]
  • Ashton, A., Cheng, Y., Helisch, A., Ware, J. (2004). Thromboxane A2 Receptor Agonists Antagonize the Proangiogenic Effects of Fibroblast Growth Factor-2:Role of Receptor Internalization, Thrombospondin-1, and αvβ3. Circulation Research, 94(6), 735-742. [More Information]
  • Ashton, A., Ware, J. (2004). Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration. Circulation Research, 95(4), 372-379. [More Information]

2003

  • Woodman, S., Ashton, A., Schubert, W., Lee, H., Williams, T., Medina, F., Wyckoff, J., Combs, T., Lisanti, M. (2003). Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli. The American Journal of Pathology, 162(6), 2059-2068. [More Information]
  • Neumeister, P., Pixley, F., Xiong, Y., Xie, H., Wu, K., Ashton, A., Cammer, M., Chan, A., Symons, M., Stanley, E., et al (2003). Cyclin D1 governs adhesion and motility of macrophages. Molecular Biology of the Cell, 14(5), 2005-2015. [More Information]
  • Ashton, A., Ware, G., Kaul, D., Ware, J. (2003). Inhibition of tumor necrosis factor alpha-mediated NFkappaB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) ligands. Journal of Biological Chemistry, 278(14), 11858-11866. [More Information]
  • Hotchkiss, K., Ashton, A., Klein, R., Lenzi, M., Zhu, G., Schwartz, E. (2003). Mechanisms by Which Tumor Cells and Monocytes Expressing the Angiogenic Factor Thymidine Phosphorylase Mediate Human Endothelial Cell Migration. Cancer Research, 63(2), 527-533. [More Information]
  • Ma, H., Calderon, T., Kessel, T., Ashton, A., Berman, J. (2003). Mechanisms of hepatocyte growth factor-mediated vascular smooth muscle cell migration. Circulation Research, 93(11), 1066-1073. [More Information]
  • Hotchkiss, K., Ashton, A., Schwartz, E. (2003). Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3. Journal of Biological Chemistry, 278(21), 19272-19279. [More Information]

2002

  • Mani, K., Ashton, A., Kitsis, R. (2002). Taking the BAD out of Adrenergic Stimulation. Journal of Molecular and Cellular Cardiology, 34, 709-712.

To update your profile click here. For support on your academic profile contact .