Associate Professor Anthony Don

Principal Research Fellow
Clinical Trials Centre

Member of the Charles Perkins Centre

Telephone 86275578

Map

Research interests

Regulation of myelination by lipid signalling molecules and the application of this in the treatment of neurodegenerative diseases.The brain is the most lipid rich organ in the body with the exception of fat tissue and much of our brain physiology is dictated by lipid metabolism and lipid-derived signalling molecules. Our lab uses sophisticated mass spectrometry methods in combination with genetic mouse models, human brain tissue samples, and neuronal cell culture models to investigate how lipid signalling molecules control myelination in normal development and normal ageing, and how these processes are dysregulated in neurodegenerative diseases (Alzheimer's Disease, Frontotemporal Dementia, Multiple Sclerosis). Myelination is essential for normal brain functioning and a major determinant of emotion and intelligence. Modern research is increasingly showing that changes to brain lipid metabolism are causative in age-related dementia. Our research is generating a greater understanding of how lipid signalling molecules and myelin lipid metabolism regulates healthy brain function. Our research into the signalling metabolite sphingosine 1-phosphate will drive the development of new therapeutics to promote remyelination and restore brain function in neurodegenerative conditions.

Control of physiological metabolism by ceramides.Ceramides are a family of lipids that appear to act as direct sensors of dietary fat intake, feeding back to regulate cellular metabolism through the regulation of key signalling pathways. Ceramides tend to promote insulin resistance and obesity. Our research group is the first in the world to have developed potent and specific inhibitors of specific ceramide synthase enzymes, which are the enzymes that catalyse ceramide synthesis. We are creating these inhibitors to open up the international research community's understanding of a key aspect of physiological metabolism, and with a view to creating new drugs to treat obesity and diabetes.

Listen to a brief interview on our fat metabolism story with ABC Radio National:

http://www.abc.net.au/radionational/programs/breakfast/new-drug-may-reduce-weight-gain-by-up-to-50-per-cent/10150922

and Newstalk ZB New Zealand:

https://www.newstalkzb.co.nz/on-air/mike-hosking-breakfast/audio/anthony-don-new-pill-could-accelerate-how-the-body-burns-up-fat/

Current research students

Project title Research student
Do S1P Receptor Agonists Stimulate Myelination in Adults? Huitong SONG

Current projects

Control of myelination by the lipid signalling molecule S1P. Our exciting new research is showing the essential role for the lipid signalling molecule S1P in the regulation of developmental myelination. In this project we use genetic mouse and cell culture models to investigate how S1P regulates oligodendrocyte function and myelination.

Developing and characterising new drugs that accelerate fat metabolism.This project involves the discovery and testing of new chemical inhibitors targeting specific isoforms of the ceramide synthase enzyme family. Long-term, the aim is to develop new drugs to treat obesity and diabetes. The project involves a combination of cell culture, mouse models, and sophisticated mass spectrometry assays,and is likely to result in the generation of new intellectual property.

Loss of myelin during normal ageing and Alzheimer's Disease. This project investigates the biochemical basis for loss of myelin - which is primarily composed of lipids - during the normal ageing process and in Alzheimer's Disease, which is the most common form of dementia associated with ageing. We are also using new mouse models lacking specific enzymes required for myelin lipid biosynthesis to determine how myelin lipid loss promotes neurodegeneration. You will have the opportunity to use very sophisticated mass spectrometry and mouse models to investigate these questions, as well as tissue from the NSW brain bank.

Key Publications:

Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS. A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, accepted 17/07/2018.

**This article was nominated by Faculty of 1000 as being of special significance in its field.https://f1000.com/prime/733852398

Couttas TA, Kain N, Tran C, Chatterton Z, Kwok JB, Don AS. Age-dependent changes to sphingolipid balance in the human hippocampus are gender-specific and may sensitize to neurodegeneration. J Alz Dis, 63: 503-514, 2018.

Couttas TA, Kain N, Suchowerska A, Quek L, Turner N, Fath T, Garner B, Don AS. Loss of ceramide synthase 2 activity, necessary for myelin lipid synthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer’s Disease. Neurobiology of Aging 43: 89-100, 2016.

Lim XY, Pickford R, Don AS. Assaying ceramide synthase activity in vitro and in living cells using liquid chromatography-mass spectrometry. Methods Mol Biol (Lipid Signalling Protocols) edited by M. Waugh, Springer, 1376: 23-33, 2016.

Couttas TA, Lim XY, Don AS. A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC. Lipids, 50:101-109, 2015.

Don AS, Hsiao JT, Bleasel JM, Couttas TA, Halliday GM, Kim WS. Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neurophathol Commun, 2:150, 2014.

Couttas TA, Kain N, Daniels B, Lim XY, Shepherd C, Kril J, Pickford R, Li H, Garner B, Don AS. The neuroprotective factor sphingosine 1-phosphate is lost early in Alzhiemer’s disease pathogenesis, Acta Neuropathol Commun, 2:9, 2014.

Abuhusain HJ, Matin A, Qiao Q, Shen H, Kain N, Day BW, Stringer BW, Daniels B, Laaksonen MA, Teo C, McDonald KL, Don AS. Sphingolipid Metabolic Balance in Glioblastoma Favours the Essential Angiogenic Factor Sphingosine 1-phosphate at the Expense of Ceramide. J Biol Chem, 288(52):37355-64, 2013.

CollisonA, HatchwellL, VerrillsN, WarkPAB, SiqueiraAP, Tooze M, Carpenter H, Don AS, Morris JC, Zimmermann N, Bartlett NW, Rothenberg ME, Johnston SL, Foster PS, Mattes J. The E3 ubiquitin ligase Midline 1 links allergen and rhinovirus exposure to asthma via targeting Protein Phosphatase 2A. Nature Med, 19(2):232-37, 2013.

Selected grants

2016

  • Restoring neuroprotective sphingosine 1-phosphate signalling in Alzheimer's Disease; Don A, Garner B, Fath T, Rosen H; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Lim, X., Pickford, R., Don, A. (2016). Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry. In Mark G. Waugh (Eds.), Lipid Signaling Protocols (2nd Edition), (pp. 11-22). New York: Humana Press. [More Information]
  • Couttas, T., Don, A. (2016). Fluorescent Assays for Ceramide Synthase Activity. In Mark G. Waugh (Eds.), Lipid Signaling Protocols (2nd Edition), (pp. 23-34). New York: Humana Press. [More Information]

Journals

  • Turner, N., Lim, X., Toop, H., Osborne, B., Brandon, A., Taylor, E., Fiveash, C., Govindaraju, H., Teo, J., McEwen, H., Couttas, T., Cooney, G., Don, A., et al (2018). A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, 9(1). [More Information]
  • Couttas, T., Kain, N., Tran, C., Chatterton, Z., Kwok, J., Don, A. (2018). Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration. Journal of Alzheimer's Disease, 63(2), 503-514. [More Information]
  • Tonkin, R., Bowles, C., Perera, C., Keating, B., Makker, P., Duffy, S., Lees, J., Tran, C., Don, A., Fath, T., et al (2018). Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Experimental Neurology, 300, 1-12. [More Information]
  • Gendron, D., Lecours, P., Lemay, A., Beaulieu, M., Huppe, C., Lee-Gosselin, A., Flamand, N., Don, A., Bissonnette, E., Blanchet, M., et al (2017). A phosphorylatable sphingosine analog induces airway smooth muscle cytostasis and reverses airway hyperresponsiveness in experimental asthma. Frontiers in Pharmacology, 8, 1-10. [More Information]
  • Lei, M., Shafique, A., Shang, K., Couttas, T., Zhao, H., Don, A., Karl, T. (2017). Contextual fear conditioning is enhanced in mice lacking functional sphingosine kinase 2. Behavioural Brain Research, 333, 9-16. [More Information]
  • Smith, A., Dun, M., Lee, E., Harrison, C., Kahl, R., Flanagan, H., Panicker, N., Mashkani, B., Don, A., et al (2016). Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors. Oncotarget, 7(30), 47465-47478. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Yaghobian, D., Don, A., Yaghobian, S., Chen, X., Pollock, C., Saad, S. (2016). Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. Clinical and Experimental Pharmacology and Physiology, 43(1), 56-66. [More Information]
  • Couttas, T., Kain, N., Suchowerska, A., Quek, L., Turner, N., Fath, T., Garner, B., Don, A. (2016). Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease. Neurobiology of Aging, 43(July), 89-100. [More Information]
  • Montgomery, M., Brown, S., Lim, X., Fiveash, C., Osborne, B., Bentley, N., Braude, J., Mitchell, T., Coster, A., Don, A., et al (2016). Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861 (11), 1828-1839. [More Information]
  • Pitman, M., Powell, J., Coolen, C., Moretti, P., Zebol, J., Pham, D., Finnie, J., Don, A., Ebert, L., Bonder, C., et al (2015). A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 6(9), 7065-7083. [More Information]
  • Couttas, T., Lim, X., Don, A. (2015). A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC. Lipids, 50(1), 101-109. [More Information]
  • Toop, H., Don, A., Morris, J. (2015). Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors. Organic and Biomolecular Chemistry, 13(48), 11593-11596. [More Information]
  • Gendron, D., Lemay, A., Tremblay, C., Lai, L., Langlois, A., Bernatchez, E., Flamand, N., Blanchet, M., Don, A., Bosse, Y., et al (2015). Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma. Respiratory Research, 16(1), 1-11. [More Information]
  • Don, A., Hsiao, J., Bleasel, J., Couttas, T., Halliday, G., Kim, W. (2014). Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathologica Communications, 2(1), 1-14. [More Information]
  • Couttas, T., Kain, N., Daniels, B., Lim, X., Shepherd, C., Kril, J., Pickford, R., Li, H., Garner, B., Don, A. (2014). Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. Acta Neuropathologica Communications, 2(1), 1-13. [More Information]
  • Don, A., Lim, X., Couttas, T. (2014). Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules, 4(1), 315-353. [More Information]
  • Abuhusain, H., Matin, A., Qiao, Q., Shen, H., Kain, N., Day, B., Stringer, B., Daniels, B., Laaksonen, M., Teo, C., et al (2013). A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. Journal of Biological Chemistry, 288(52), 37355-37564. [More Information]
  • Kim, W., Hsiao, J., Bhatia, S., Glaros, E., Don, A., Tsuruoka, S., Weickert, C., Halliday, G. (2013). ABCA8 stimulates sphingomyelin production in oligodendrocytes. Biochemical Journal, 452(3), 401-410. [More Information]
  • Bhatia, S., Jenner, A., Li, H., Ruberu, K., Spiro, A., Shepherd, C., Kril, J., Kain, N., Don, A., Garner, B. (2013). Increased Apolipoprotein D Dimer Formation in Alzheimer's Disease Hippocampus is Associated with Lipid Conjugated Diene Levels. Journal of Alzheimer's Disease, 35(3), 475-486. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Collison, A., Hatchwell, L., Verrills, N., Wark, P., de Siqueira, A., Tooze, M., Carpenter, H., Don, A., Morris, J., Zimmermann, N., et al (2013). The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nature Medicine, 19(2), 232-237. [More Information]
  • Kim, H., Qiao, Q., Toop, H., Morris, J., Don, A. (2012). A Fluorescent Assay for Ceramide Synthase Activity. Journal of Lipid Research, 53(8), 1701-1707. [More Information]
  • Wallington-Beddoe, C., Don, A., Hewson, J., Qiao, Q., Papa, R., Lock, R., Bradstock, K., Bendall, L. (2012). Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia. PloS One, 7(5), 1-7. [More Information]
  • Wong, J., Abuhusain, H., McDonald, K., Don, A. (2012). MMSAT: Automated Quantification of Metabolites in Selected Reaction Monitoring Experiments. Analytical Chemistry, 84(1), 470-474. [More Information]
  • Hejazi, L., Wong, J., Cheng, D., Proschogo, N., Ebrahimi, D., Garner, B., Don, A. (2011). Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains. The Biochemical Journal, 438(1), 165-175. [More Information]
  • Park, D., Don, A., Massamiri, T., Karwa, A., Warner, B., MacDonald, J., Hemenway, C., Naik, A., Kuan, K., Hogg, P., et al (2011). Noninvasive imaging of cell death using an Hsp90 ligand. Journal of the American Chemical Society, 133(9), 2832-2835. [More Information]
  • Magenau, A., Benzing, C., Proschogo, N., Don, A., Hejazi, L., Karunakaran, D., Jessup, W., Gaus, K. (2011). Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. Traffic, 12(12), 1730-1743. [More Information]
  • Jary, E., Bee, T., Walker, S., Chung, S., Seo, K., Morris, J., Don, A. (2010). Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate. Molecular Pharmacology, 78(4), 685-692. [More Information]
  • Dilda, P., Don, A., Tanabe, K., Higgins, V., Allen, J., Allen, J., Dawes, I. (2005). Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. Journal of the National Cancer Institute, 97(20), 1539-1547. [More Information]

2018

  • Turner, N., Lim, X., Toop, H., Osborne, B., Brandon, A., Taylor, E., Fiveash, C., Govindaraju, H., Teo, J., McEwen, H., Couttas, T., Cooney, G., Don, A., et al (2018). A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, 9(1). [More Information]
  • Couttas, T., Kain, N., Tran, C., Chatterton, Z., Kwok, J., Don, A. (2018). Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration. Journal of Alzheimer's Disease, 63(2), 503-514. [More Information]
  • Tonkin, R., Bowles, C., Perera, C., Keating, B., Makker, P., Duffy, S., Lees, J., Tran, C., Don, A., Fath, T., et al (2018). Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Experimental Neurology, 300, 1-12. [More Information]

2017

  • Gendron, D., Lecours, P., Lemay, A., Beaulieu, M., Huppe, C., Lee-Gosselin, A., Flamand, N., Don, A., Bissonnette, E., Blanchet, M., et al (2017). A phosphorylatable sphingosine analog induces airway smooth muscle cytostasis and reverses airway hyperresponsiveness in experimental asthma. Frontiers in Pharmacology, 8, 1-10. [More Information]
  • Lei, M., Shafique, A., Shang, K., Couttas, T., Zhao, H., Don, A., Karl, T. (2017). Contextual fear conditioning is enhanced in mice lacking functional sphingosine kinase 2. Behavioural Brain Research, 333, 9-16. [More Information]

2016

  • Smith, A., Dun, M., Lee, E., Harrison, C., Kahl, R., Flanagan, H., Panicker, N., Mashkani, B., Don, A., et al (2016). Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors. Oncotarget, 7(30), 47465-47478. [More Information]
  • Lim, X., Pickford, R., Don, A. (2016). Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry. In Mark G. Waugh (Eds.), Lipid Signaling Protocols (2nd Edition), (pp. 11-22). New York: Humana Press. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Couttas, T., Don, A. (2016). Fluorescent Assays for Ceramide Synthase Activity. In Mark G. Waugh (Eds.), Lipid Signaling Protocols (2nd Edition), (pp. 23-34). New York: Humana Press. [More Information]
  • Yaghobian, D., Don, A., Yaghobian, S., Chen, X., Pollock, C., Saad, S. (2016). Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. Clinical and Experimental Pharmacology and Physiology, 43(1), 56-66. [More Information]
  • Couttas, T., Kain, N., Suchowerska, A., Quek, L., Turner, N., Fath, T., Garner, B., Don, A. (2016). Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease. Neurobiology of Aging, 43(July), 89-100. [More Information]
  • Montgomery, M., Brown, S., Lim, X., Fiveash, C., Osborne, B., Bentley, N., Braude, J., Mitchell, T., Coster, A., Don, A., et al (2016). Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861 (11), 1828-1839. [More Information]

2015

  • Pitman, M., Powell, J., Coolen, C., Moretti, P., Zebol, J., Pham, D., Finnie, J., Don, A., Ebert, L., Bonder, C., et al (2015). A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 6(9), 7065-7083. [More Information]
  • Couttas, T., Lim, X., Don, A. (2015). A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC. Lipids, 50(1), 101-109. [More Information]
  • Toop, H., Don, A., Morris, J. (2015). Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors. Organic and Biomolecular Chemistry, 13(48), 11593-11596. [More Information]
  • Gendron, D., Lemay, A., Tremblay, C., Lai, L., Langlois, A., Bernatchez, E., Flamand, N., Blanchet, M., Don, A., Bosse, Y., et al (2015). Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma. Respiratory Research, 16(1), 1-11. [More Information]

2014

  • Don, A., Hsiao, J., Bleasel, J., Couttas, T., Halliday, G., Kim, W. (2014). Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathologica Communications, 2(1), 1-14. [More Information]
  • Couttas, T., Kain, N., Daniels, B., Lim, X., Shepherd, C., Kril, J., Pickford, R., Li, H., Garner, B., Don, A. (2014). Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. Acta Neuropathologica Communications, 2(1), 1-13. [More Information]
  • Don, A., Lim, X., Couttas, T. (2014). Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules, 4(1), 315-353. [More Information]

2013

  • Abuhusain, H., Matin, A., Qiao, Q., Shen, H., Kain, N., Day, B., Stringer, B., Daniels, B., Laaksonen, M., Teo, C., et al (2013). A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. Journal of Biological Chemistry, 288(52), 37355-37564. [More Information]
  • Kim, W., Hsiao, J., Bhatia, S., Glaros, E., Don, A., Tsuruoka, S., Weickert, C., Halliday, G. (2013). ABCA8 stimulates sphingomyelin production in oligodendrocytes. Biochemical Journal, 452(3), 401-410. [More Information]
  • Bhatia, S., Jenner, A., Li, H., Ruberu, K., Spiro, A., Shepherd, C., Kril, J., Kain, N., Don, A., Garner, B. (2013). Increased Apolipoprotein D Dimer Formation in Alzheimer's Disease Hippocampus is Associated with Lipid Conjugated Diene Levels. Journal of Alzheimer's Disease, 35(3), 475-486. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Collison, A., Hatchwell, L., Verrills, N., Wark, P., de Siqueira, A., Tooze, M., Carpenter, H., Don, A., Morris, J., Zimmermann, N., et al (2013). The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nature Medicine, 19(2), 232-237. [More Information]

2012

  • Kim, H., Qiao, Q., Toop, H., Morris, J., Don, A. (2012). A Fluorescent Assay for Ceramide Synthase Activity. Journal of Lipid Research, 53(8), 1701-1707. [More Information]
  • Wallington-Beddoe, C., Don, A., Hewson, J., Qiao, Q., Papa, R., Lock, R., Bradstock, K., Bendall, L. (2012). Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia. PloS One, 7(5), 1-7. [More Information]
  • Wong, J., Abuhusain, H., McDonald, K., Don, A. (2012). MMSAT: Automated Quantification of Metabolites in Selected Reaction Monitoring Experiments. Analytical Chemistry, 84(1), 470-474. [More Information]

2011

  • Hejazi, L., Wong, J., Cheng, D., Proschogo, N., Ebrahimi, D., Garner, B., Don, A. (2011). Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains. The Biochemical Journal, 438(1), 165-175. [More Information]
  • Park, D., Don, A., Massamiri, T., Karwa, A., Warner, B., MacDonald, J., Hemenway, C., Naik, A., Kuan, K., Hogg, P., et al (2011). Noninvasive imaging of cell death using an Hsp90 ligand. Journal of the American Chemical Society, 133(9), 2832-2835. [More Information]
  • Magenau, A., Benzing, C., Proschogo, N., Don, A., Hejazi, L., Karunakaran, D., Jessup, W., Gaus, K. (2011). Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. Traffic, 12(12), 1730-1743. [More Information]

2010

  • Jary, E., Bee, T., Walker, S., Chung, S., Seo, K., Morris, J., Don, A. (2010). Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate. Molecular Pharmacology, 78(4), 685-692. [More Information]

2005

  • Dilda, P., Don, A., Tanabe, K., Higgins, V., Allen, J., Allen, J., Dawes, I. (2005). Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. Journal of the National Cancer Institute, 97(20), 1539-1547. [More Information]

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