Associate Professor Anthony Don

Principal Research Fellow
Clinical Trials Centre

Member of the Charles Perkins Centre

Telephone 86275578

Map

Research interests

How does altered lipid metabolism pre-dispose to Alzhiemer's Disease and how can we use this information to develop new therapies?The brain is the most lipid rich organ in the body with the exception of fat tissue and much, if not most, of our brain physiology is dictated by lipid metabolism and lipid-derived signalling molecules. Our lab uses sophisticated mass spectrometry methods in combination with genetic mouse models, human brain tissue samples, and neuronal cell culture models to describe changes to lipid metabolism that occur very early in the pathogenesis of Alzheimer's Disease. These changes occur many years, possibly decades, before the disease develops and are likely to be amongst the very earliest biochemical events that drive disease development, as is the case for a vast number of neurological diseases. Through a greater understanding of the biochemical basis for Alzheimer's, we are able to design and develop new therapeutics to target the disease. An example for our current research is the use of sphingosine 1-phosphate receptor agonist drugs to restore neuroprotective signalling in Alzheimer's Disease.

Accelerating fat metabolism by skeletal muscle to enhance weight loss. Our research group is the first in the world to have developed potent and specific inhibitors of specific ceramide synthase enzymes. The ceramide synthases catalyse the formation of the lipid ceramide, which has been known for some time to promote obesity and insulin resistance. In this project we are using rodent and cell culture models to characterise our new ceramide synthase inhibitor drug, and have shown that the drug prevents fat deposition and storage by accelerating the use of fats as fuels in skeletal muscle.

Listen to a brief interview on our fat metabolism story with ABC Radio National:

http://www.abc.net.au/radionational/programs/breakfast/new-drug-may-reduce-weight-gain-by-up-to-50-per-cent/10150922

and Newstalk ZB New Zealand:

https://www.newstalkzb.co.nz/on-air/mike-hosking-breakfast/audio/anthony-don-new-pill-could-accelerate-how-the-body-burns-up-fat/

Current projects

Developing and characterising new drugs that accelerate fat metabolism. In this project you will determine the cellular and molecular basis for acceleration of fat metabolism by our new ceramide synthase 1 inhibitor. Our new, recently patented, drug reduces fat deposition and storage in mice fed a high fat diet by accelerating fat metabolism in skeletal muscles. The project involves a combination of cell culture and mouse models, and uses sophisticated mass spectrometry assays.

An alternative or complementary project involves the discovery and testing of new ceramide synthase inhibitors targeting the ceramide synthase 6 isoform, and is likely to result in the generation of new intellectual property.

Loss of myelin during normal ageing and Alzheimer's Disease. This project investigates the biochemical basis for loss of myelin - which is primarily composed of lipids - during the normal ageing process and in Alzheimer's Disease, which is the most common form of dementia associated with ageing. We are also using new mouse models lacking specific enzymes required for myelin lipid biosynthesis to determine how myelin lipid loss promotes neurodegeneration. You will have the opportunity to use very sophisticated mass spectrometry and mouse models to investigate these questions, as well as tissue from the NSW brain bank.

Key Publications:

Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS. A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, accepted 17/07/2018.

**This article was nominated by Faculty of 1000 as being of special significance in its field.https://f1000.com/prime/733852398

Couttas TA, Kain N, Tran C, Chatterton Z, Kwok JB, Don AS. Age-dependent changes to sphingolipid balance in the human hippocampus are gender-specific and may sensitize to neurodegeneration. J Alz Dis, 63: 503-514, 2018.

Couttas TA, Kain N, Suchowerska A, Quek L, Turner N, Fath T, Garner B, Don AS. Loss of ceramide synthase 2 activity, necessary for myelin lipid synthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer’s Disease. Neurobiology of Aging 43: 89-100, 2016.

Lim XY, Pickford R, Don AS. Assaying ceramide synthase activity in vitro and in living cells using liquid chromatography-mass spectrometry. Methods Mol Biol (Lipid Signalling Protocols) edited by M. Waugh, Springer, 1376: 23-33, 2016.

Couttas TA, Lim XY, Don AS. A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC. Lipids, 50:101-109, 2015.

Don AS, Hsiao JT, Bleasel JM, Couttas TA, Halliday GM, Kim WS. Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neurophathol Commun, 2:150, 2014.

Couttas TA, Kain N, Daniels B, Lim XY, Shepherd C, Kril J, Pickford R, Li H, Garner B, Don AS. The neuroprotective factor sphingosine 1-phosphate is lost early in Alzhiemer’s disease pathogenesis, Acta Neuropathol Commun, 2:9, 2014.

Abuhusain HJ, Matin A, Qiao Q, Shen H, Kain N, Day BW, Stringer BW, Daniels B, Laaksonen MA, Teo C, McDonald KL, Don AS. Sphingolipid Metabolic Balance in Glioblastoma Favours the Essential Angiogenic Factor Sphingosine 1-phosphate at the Expense of Ceramide. J Biol Chem, 288(52):37355-64, 2013.

CollisonA, HatchwellL, VerrillsN, WarkPAB, SiqueiraAP, Tooze M, Carpenter H, Don AS, Morris JC, Zimmermann N, Bartlett NW, Rothenberg ME, Johnston SL, Foster PS, Mattes J. The E3 ubiquitin ligase Midline 1 links allergen and rhinovirus exposure to asthma via targeting Protein Phosphatase 2A. Nature Med, 19(2):232-37, 2013.

Selected grants

2016

  • Restoring neuroprotective sphingosine 1-phosphate signalling in Alzheimer's Disease; Don A, Garner B, Fath T, Rosen H; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Lim, X., Pickford, R., Don, A. (2016). Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry. In Mark G. Waugh (Eds.), Lipid Signaling Protocols (2nd Edition), (pp. 11-22). New York: Humana Press. [More Information]
  • Couttas, T., Don, A. (2016). Fluorescent Assays for Ceramide Synthase Activity. In Mark G. Waugh (Eds.), Lipid Signaling Protocols (2nd Edition), (pp. 23-34). New York: Humana Press. [More Information]

Journals

  • Turner, N., Lim, X., Toop, H., Osborne, B., Brandon, A., Taylor, E., Fiveash, C., Govindaraju, H., Teo, J., McEwen, H., Couttas, T., Cooney, G., Don, A., et al (2018). A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, 9(1). [More Information]
  • Couttas, T., Kain, N., Tran, C., Chatterton, Z., Kwok, J., Don, A. (2018). Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration. Journal of Alzheimer's Disease, 63(2), 503-514. [More Information]
  • Tonkin, R., Bowles, C., Perera, C., Keating, B., Makker, P., Duffy, S., Lees, J., Tran, C., Don, A., Fath, T., et al (2018). Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Experimental Neurology, 300, 1-12. [More Information]
  • Gendron, D., Lecours, P., Lemay, A., Beaulieu, M., Huppe, C., Lee-Gosselin, A., Flamand, N., Don, A., Bissonnette, E., Blanchet, M., et al (2017). A phosphorylatable sphingosine analog induces airway smooth muscle cytostasis and reverses airway hyperresponsiveness in experimental asthma. Frontiers in Pharmacology, 8, 1-10. [More Information]
  • Lei, M., Shafique, A., Shang, K., Couttas, T., Zhao, H., Don, A., Karl, T. (2017). Contextual fear conditioning is enhanced in mice lacking functional sphingosine kinase 2. Behavioural Brain Research, 333, 9-16. [More Information]
  • Smith, A., Dun, M., Lee, E., Harrison, C., Kahl, R., Flanagan, H., Panicker, N., Mashkani, B., Don, A., et al (2016). Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors. Oncotarget, 7(30), 47465-47478. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Yaghobian, D., Don, A., Yaghobian, S., Chen, X., Pollock, C., Saad, S. (2016). Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. Clinical and Experimental Pharmacology and Physiology, 43(1), 56-66. [More Information]
  • Couttas, T., Kain, N., Suchowerska, A., Quek, L., Turner, N., Fath, T., Garner, B., Don, A. (2016). Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease. Neurobiology of Aging, 43(July), 89-100. [More Information]
  • Montgomery, M., Brown, S., Lim, X., Fiveash, C., Osborne, B., Bentley, N., Braude, J., Mitchell, T., Coster, A., Don, A., et al (2016). Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species. Biochimica et Biophysica Acta, 1861 (11), 1828-1839. [More Information]
  • Pitman, M., Powell, J., Coolen, C., Moretti, P., Zebol, J., Pham, D., Finnie, J., Don, A., Ebert, L., Bonder, C., et al (2015). A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 6(9), 7065-7083. [More Information]
  • Couttas, T., Lim, X., Don, A. (2015). A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC. Lipids, 50(1), 101-109. [More Information]
  • Toop, H., Don, A., Morris, J. (2015). Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors. Organic and Biomolecular Chemistry, 13(48), 11593-11596. [More Information]
  • Gendron, D., Lemay, A., Tremblay, C., Lai, L., Langlois, A., Bernatchez, E., Flamand, N., Blanchet, M., Don, A., Bosse, Y., et al (2015). Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma. Respiratory Research, 16(1), 1-11. [More Information]
  • Don, A., Hsiao, J., Bleasel, J., Couttas, T., Halliday, G., Kim, W. (2014). Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathologica Communications, 2(1), 1-14. [More Information]
  • Couttas, T., Kain, N., Daniels, B., Lim, X., Shepherd, C., Kril, J., Pickford, R., Li, H., Garner, B., Don, A. (2014). Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. Acta Neuropathologica Communications, 2(1), 1-13. [More Information]
  • Don, A., Lim, X., Couttas, T. (2014). Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules, 4(1), 315-353. [More Information]
  • Abuhusain, H., Matin, A., Qiao, Q., Shen, H., Kain, N., Day, B., Stringer, B., Daniels, B., Laaksonen, M., Teo, C., et al (2013). A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. Journal of Biological Chemistry, 288(52), 37355-37564. [More Information]
  • Kim, W., Hsiao, J., Bhatia, S., Glaros, E., Don, A., Tsuruoka, S., Weickert, C., Halliday, G. (2013). ABCA8 stimulates sphingomyelin production in oligodendrocytes. Biochemical Journal, 452(3), 401-410. [More Information]
  • Bhatia, S., Jenner, A., Li, H., Ruberu, K., Spiro, A., Shepherd, C., Kril, J., Kain, N., Don, A., Garner, B. (2013). Increased Apolipoprotein D Dimer Formation in Alzheimer's Disease Hippocampus is Associated with Lipid Conjugated Diene Levels. Journal of Alzheimer's Disease, 35(3), 475-486. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Collison, A., Hatchwell, L., Verrills, N., Wark, P., de Siqueira, A., Tooze, M., Carpenter, H., Don, A., Morris, J., Zimmermann, N., et al (2013). The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nature Medicine, 19(2), 232-237. [More Information]
  • Kim, H., Qiao, Q., Toop, H., Morris, J., Don, A. (2012). A Fluorescent Assay for Ceramide Synthase Activity. Journal of Lipid Research, 53(8), 1701-1707. [More Information]
  • Wallington-Beddoe, C., Don, A., Hewson, J., Qiao, Q., Papa, R., Lock, R., Bradstock, K., Bendall, L. (2012). Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia. PloS One, 7(5), 1-7. [More Information]
  • Wong, J., Abuhusain, H., McDonald, K., Don, A. (2012). MMSAT: Automated Quantification of Metabolites in Selected Reaction Monitoring Experiments. Analytical Chemistry, 84(1), 470-474. [More Information]
  • Hejazi, L., Wong, J., Cheng, D., Proschogo, N., Ebrahimi, D., Garner, B., Don, A. (2011). Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains. The Biochemical Journal, 438(1), 165-175. [More Information]
  • Park, D., Don, A., Massamiri, T., Karwa, A., Warner, B., MacDonald, J., Hemenway, C., Naik, A., Kuan, K., Hogg, P., et al (2011). Noninvasive imaging of cell death using an Hsp90 ligand. Journal of the American Chemical Society, 133(9), 2832-2835. [More Information]
  • Magenau, A., Benzing, C., Proschogo, N., Don, A., Hejazi, L., Karunakaran, D., Jessup, W., Gaus, K. (2011). Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. Traffic, 12(12), 1730-1743. [More Information]
  • Jary, E., Bee, T., Walker, S., Chung, S., Seo, K., Morris, J., Don, A. (2010). Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate. Molecular Pharmacology, 78(4), 685-692. [More Information]
  • Dilda, P., Don, A., Tanabe, K., Higgins, V., Allen, J., Allen, J., Dawes, I. (2005). Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. Journal of the National Cancer Institute, 97(20), 1539-1547. [More Information]

2018

  • Turner, N., Lim, X., Toop, H., Osborne, B., Brandon, A., Taylor, E., Fiveash, C., Govindaraju, H., Teo, J., McEwen, H., Couttas, T., Cooney, G., Don, A., et al (2018). A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, 9(1). [More Information]
  • Couttas, T., Kain, N., Tran, C., Chatterton, Z., Kwok, J., Don, A. (2018). Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration. Journal of Alzheimer's Disease, 63(2), 503-514. [More Information]
  • Tonkin, R., Bowles, C., Perera, C., Keating, B., Makker, P., Duffy, S., Lees, J., Tran, C., Don, A., Fath, T., et al (2018). Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Experimental Neurology, 300, 1-12. [More Information]

2017

  • Gendron, D., Lecours, P., Lemay, A., Beaulieu, M., Huppe, C., Lee-Gosselin, A., Flamand, N., Don, A., Bissonnette, E., Blanchet, M., et al (2017). A phosphorylatable sphingosine analog induces airway smooth muscle cytostasis and reverses airway hyperresponsiveness in experimental asthma. Frontiers in Pharmacology, 8, 1-10. [More Information]
  • Lei, M., Shafique, A., Shang, K., Couttas, T., Zhao, H., Don, A., Karl, T. (2017). Contextual fear conditioning is enhanced in mice lacking functional sphingosine kinase 2. Behavioural Brain Research, 333, 9-16. [More Information]

2016

  • Smith, A., Dun, M., Lee, E., Harrison, C., Kahl, R., Flanagan, H., Panicker, N., Mashkani, B., Don, A., et al (2016). Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors. Oncotarget, 7(30), 47465-47478. [More Information]
  • Lim, X., Pickford, R., Don, A. (2016). Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry. In Mark G. Waugh (Eds.), Lipid Signaling Protocols (2nd Edition), (pp. 11-22). New York: Humana Press. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Couttas, T., Don, A. (2016). Fluorescent Assays for Ceramide Synthase Activity. In Mark G. Waugh (Eds.), Lipid Signaling Protocols (2nd Edition), (pp. 23-34). New York: Humana Press. [More Information]
  • Yaghobian, D., Don, A., Yaghobian, S., Chen, X., Pollock, C., Saad, S. (2016). Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. Clinical and Experimental Pharmacology and Physiology, 43(1), 56-66. [More Information]
  • Couttas, T., Kain, N., Suchowerska, A., Quek, L., Turner, N., Fath, T., Garner, B., Don, A. (2016). Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease. Neurobiology of Aging, 43(July), 89-100. [More Information]
  • Montgomery, M., Brown, S., Lim, X., Fiveash, C., Osborne, B., Bentley, N., Braude, J., Mitchell, T., Coster, A., Don, A., et al (2016). Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species. Biochimica et Biophysica Acta, 1861 (11), 1828-1839. [More Information]

2015

  • Pitman, M., Powell, J., Coolen, C., Moretti, P., Zebol, J., Pham, D., Finnie, J., Don, A., Ebert, L., Bonder, C., et al (2015). A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 6(9), 7065-7083. [More Information]
  • Couttas, T., Lim, X., Don, A. (2015). A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC. Lipids, 50(1), 101-109. [More Information]
  • Toop, H., Don, A., Morris, J. (2015). Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors. Organic and Biomolecular Chemistry, 13(48), 11593-11596. [More Information]
  • Gendron, D., Lemay, A., Tremblay, C., Lai, L., Langlois, A., Bernatchez, E., Flamand, N., Blanchet, M., Don, A., Bosse, Y., et al (2015). Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma. Respiratory Research, 16(1), 1-11. [More Information]

2014

  • Don, A., Hsiao, J., Bleasel, J., Couttas, T., Halliday, G., Kim, W. (2014). Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathologica Communications, 2(1), 1-14. [More Information]
  • Couttas, T., Kain, N., Daniels, B., Lim, X., Shepherd, C., Kril, J., Pickford, R., Li, H., Garner, B., Don, A. (2014). Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. Acta Neuropathologica Communications, 2(1), 1-13. [More Information]
  • Don, A., Lim, X., Couttas, T. (2014). Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules, 4(1), 315-353. [More Information]

2013

  • Abuhusain, H., Matin, A., Qiao, Q., Shen, H., Kain, N., Day, B., Stringer, B., Daniels, B., Laaksonen, M., Teo, C., et al (2013). A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. Journal of Biological Chemistry, 288(52), 37355-37564. [More Information]
  • Kim, W., Hsiao, J., Bhatia, S., Glaros, E., Don, A., Tsuruoka, S., Weickert, C., Halliday, G. (2013). ABCA8 stimulates sphingomyelin production in oligodendrocytes. Biochemical Journal, 452(3), 401-410. [More Information]
  • Bhatia, S., Jenner, A., Li, H., Ruberu, K., Spiro, A., Shepherd, C., Kril, J., Kain, N., Don, A., Garner, B. (2013). Increased Apolipoprotein D Dimer Formation in Alzheimer's Disease Hippocampus is Associated with Lipid Conjugated Diene Levels. Journal of Alzheimer's Disease, 35(3), 475-486. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Collison, A., Hatchwell, L., Verrills, N., Wark, P., de Siqueira, A., Tooze, M., Carpenter, H., Don, A., Morris, J., Zimmermann, N., et al (2013). The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nature Medicine, 19(2), 232-237. [More Information]

2012

  • Kim, H., Qiao, Q., Toop, H., Morris, J., Don, A. (2012). A Fluorescent Assay for Ceramide Synthase Activity. Journal of Lipid Research, 53(8), 1701-1707. [More Information]
  • Wallington-Beddoe, C., Don, A., Hewson, J., Qiao, Q., Papa, R., Lock, R., Bradstock, K., Bendall, L. (2012). Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia. PloS One, 7(5), 1-7. [More Information]
  • Wong, J., Abuhusain, H., McDonald, K., Don, A. (2012). MMSAT: Automated Quantification of Metabolites in Selected Reaction Monitoring Experiments. Analytical Chemistry, 84(1), 470-474. [More Information]

2011

  • Hejazi, L., Wong, J., Cheng, D., Proschogo, N., Ebrahimi, D., Garner, B., Don, A. (2011). Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains. The Biochemical Journal, 438(1), 165-175. [More Information]
  • Park, D., Don, A., Massamiri, T., Karwa, A., Warner, B., MacDonald, J., Hemenway, C., Naik, A., Kuan, K., Hogg, P., et al (2011). Noninvasive imaging of cell death using an Hsp90 ligand. Journal of the American Chemical Society, 133(9), 2832-2835. [More Information]
  • Magenau, A., Benzing, C., Proschogo, N., Don, A., Hejazi, L., Karunakaran, D., Jessup, W., Gaus, K. (2011). Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. Traffic, 12(12), 1730-1743. [More Information]

2010

  • Jary, E., Bee, T., Walker, S., Chung, S., Seo, K., Morris, J., Don, A. (2010). Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate. Molecular Pharmacology, 78(4), 685-692. [More Information]

2005

  • Dilda, P., Don, A., Tanabe, K., Higgins, V., Allen, J., Allen, J., Dawes, I. (2005). Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. Journal of the National Cancer Institute, 97(20), 1539-1547. [More Information]

To update your profile click here. For support on your academic profile contact .