Emeritus Professor Antony Basten

AO
Emeritus Professor
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6135
Fax +61 2 9565 6111

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Research interests

immunity & vaccination, cancer immunology, monoclonal antibody therapy, hygiene hypothesis and allergy, biotechnology

Selected grants

2004

  • AID automated elispot reader system ELR02; Basten A, Mackay C; Clive & Vera Ramaciotti Foundation/Research Grant.
  • Verdi V2 DPSS laser system; Fazekas B, Rasko J, Britton W, Tangye S, Brink R, Basten A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Cellular and molecular studies of the adaptive immune response in health and disease; Basten A, Fazekas B, Brink R, Tangye S, Mackay F; National Health and Medical Research Council (NHMRC)/Program Grants.

2001

  • A recombinant protein facility at the University of Sydney; Christopherson R, Wake R, Basten A, Britton W; WELLCOME TRUST/Major Equipment Awards for Biomedical Research in Australia.

Selected publications

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Journals

  • Berbic, M., Ng, C., Black, K., Markham, R., Russell, P., Basten, A., Fraser, I., Hey-Cunningham, A. (2013). A Novel Pilot Study of Endometrial Stromal Cells and Immune Cell Populations in Sentinel Uterine-Draining Lymph Nodes During the Menstrual Cycle and in Endometriosis. Reproductive Sciences, 20(11), 1339-1348. [More Information]
  • Chan, T., Wood, K., Hermes, J., Butt, D., Jolly, C., Basten, A., Brink, R. (2012). Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen. Immunity, 37(5), 893-904. [More Information]
  • Basten, A., Silveira, P. (2010). B-cell tolerance: mechanisms and implications. Current Opinion in Immunology, 22(5), 566-74. [More Information]
  • Cox, S., Stolp, J., Hallahan, N., Counette, J., Zhang, W., Serreze, D., Basten, A., Silveira, P. (2010). Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a b-cell neo-self-antigen in type 1 diabetes prone NOD mice. European Journal of Immunology, 40(12), 3413-3425. [More Information]
  • Basten, A., Fazekas, B. (2008). Special regulatory T-cell review: T-cell dependent suppression revisited. Immunology, 123, 33-39.
  • Gardam, S., Sierro, F., Basten, A., Mackay, F., Brink, R. (2008). TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity, 28(3), 391-401. [More Information]
  • Basten, A. (2007). The evolution of clinical immunology and allergy in Australia. Immunology and Cell Biology, 86(1). [More Information]
  • Paus, D., Phan, T., Chan, T., Gardam, S., Basten, A., Brink, R. (2006). Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. The Journal of Experimental Medicine, 203(4), 1081-1091. [More Information]
  • Phan, T., Paus, D., Chan, T., Turner, M., Nutt, S., Basten, A., Brink, R. (2006). High affinity germinal center B cells are actively selected into the plasma cell compartment. The Journal of Experimental Medicine, 203(11), 2419-2424. [More Information]
  • Phan, T., Gardam, S., Basten, A., Brink, R. (2005). Altered migration, recruitment, and somatic hypermutation in the early response of marginal zone B cells to T cell-dependent antigen. Journal of Immunology, 174(8), 4567-4578. [More Information]
  • Ismail, N., Basten, A., Briscoe, H., Bretscher, P. (2005). Increasing the foreignness of an antigen, by coupling a second and foreign antigen to it, increases the T helper type 2 component of the immune response to the first antigen. Immunology, 115(1), 34-41. [More Information]
  • Grech, A., Gardam, S., Chan, T., Quinn, R., Gonzales, R., Basten, A., Brink, R. (2005). Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site. Journal of Biological Chemistry, 280(36), 31572-81. [More Information]
  • Thien, M., Phan, T., Gardam, S., Amesbury, M., Basten, A., Mackay, F., Brink, R. (2004). Excess Baff Rescues Self-Reactive B Cells From Peripheral Deletion And Allows Them To Enter Forbidden Follicular And Marginal Zone Niches. Immunity, 20(6), 785-798. [More Information]
  • Grech, A., Amesbury, M., Chan, T., Gardam, S., Basten, A., Brink, R. (2004). Traf2 Differentially Regulates The Canonical And Noncanonical Pathways Of Nf-Kappab Activation In Mature B Cells. Immunity, 21(5), 629-642.
  • Phan, T., Amesbury, M., Gardam, S., Crosbie, J., Hasbold, J., Hodgkin, P., Basten, A., Brink, R. (2003). B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells. The Journal of Experimental Medicine, 197(7), 845-860.
  • Sze, D., Brown, R., Yang, S., Gibson, J., Ho, J., Fazekas, B., Basten, A., Joshua, D. (2003). Prediction of high affinity class I-restricted multiple myeloma idiotype peptide epitopes. Leukemia and lymphoma, 44(9), 1557-1568.
  • Cook, A., Oganesian, L., Harumal, P., Basten, A., Brink, R., Jolly, C. (2003). Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. Journal of Immunology, 171(2003), 6456-6464.
  • Sze, D., Giesajtis,, G., Brown, R., Raitakari, M., Gibson, J., Ho, J., Baxter, A., Fazekas, B., Basten, A., Joshua, D. (2001). Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8+Cd57+CD28- compartment. Blood, 98(9), 2817-2827.
  • Ho, J., Basten, A., Gibson, J., Joshua, D., Brown, R., Pelka, G. (2001). Illegitimate switch recombinations are present in approximately half of primary myeloma tumors, but do not relate to known prognostic indicators or survival. Blood, 97, 490-495.
  • Basten, A., Cook, M., Korner, H., Winkler, T., Sedgwick, J., Rolliinghoff, M. (2001). Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles. Immunology and Cell Biology, 79, 54-61.

Conferences

  • Berbic, M., Hey Cunningham, A., Ng, C., Basten, A., Markham, R., Fraser, I. (2010). A novel approach into better understanding of the role of uterine leukocytes during the time of menstruation and in presence of endometriosis. XI International Congress of Reproductive Immunology, Australia: Palm Cove.
  • Phan, T., Paus, D., Chan, T., Gardam, S., Amesbury, M., Crosbie, J., Basten, A., Brink, R. (2005). Visualising B Cell Responses to Protein Antigens of Varying Affinity in Vivo. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.

2013

  • Berbic, M., Ng, C., Black, K., Markham, R., Russell, P., Basten, A., Fraser, I., Hey-Cunningham, A. (2013). A Novel Pilot Study of Endometrial Stromal Cells and Immune Cell Populations in Sentinel Uterine-Draining Lymph Nodes During the Menstrual Cycle and in Endometriosis. Reproductive Sciences, 20(11), 1339-1348. [More Information]

2012

  • Chan, T., Wood, K., Hermes, J., Butt, D., Jolly, C., Basten, A., Brink, R. (2012). Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen. Immunity, 37(5), 893-904. [More Information]

2010

  • Berbic, M., Hey Cunningham, A., Ng, C., Basten, A., Markham, R., Fraser, I. (2010). A novel approach into better understanding of the role of uterine leukocytes during the time of menstruation and in presence of endometriosis. XI International Congress of Reproductive Immunology, Australia: Palm Cove.
  • Basten, A., Silveira, P. (2010). B-cell tolerance: mechanisms and implications. Current Opinion in Immunology, 22(5), 566-74. [More Information]
  • Cox, S., Stolp, J., Hallahan, N., Counette, J., Zhang, W., Serreze, D., Basten, A., Silveira, P. (2010). Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a b-cell neo-self-antigen in type 1 diabetes prone NOD mice. European Journal of Immunology, 40(12), 3413-3425. [More Information]

2008

  • Basten, A., Fazekas, B. (2008). Special regulatory T-cell review: T-cell dependent suppression revisited. Immunology, 123, 33-39.
  • Gardam, S., Sierro, F., Basten, A., Mackay, F., Brink, R. (2008). TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity, 28(3), 391-401. [More Information]

2007

  • Basten, A. (2007). The evolution of clinical immunology and allergy in Australia. Immunology and Cell Biology, 86(1). [More Information]

2006

  • Paus, D., Phan, T., Chan, T., Gardam, S., Basten, A., Brink, R. (2006). Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. The Journal of Experimental Medicine, 203(4), 1081-1091. [More Information]
  • Phan, T., Paus, D., Chan, T., Turner, M., Nutt, S., Basten, A., Brink, R. (2006). High affinity germinal center B cells are actively selected into the plasma cell compartment. The Journal of Experimental Medicine, 203(11), 2419-2424. [More Information]

2005

  • Phan, T., Gardam, S., Basten, A., Brink, R. (2005). Altered migration, recruitment, and somatic hypermutation in the early response of marginal zone B cells to T cell-dependent antigen. Journal of Immunology, 174(8), 4567-4578. [More Information]
  • Ismail, N., Basten, A., Briscoe, H., Bretscher, P. (2005). Increasing the foreignness of an antigen, by coupling a second and foreign antigen to it, increases the T helper type 2 component of the immune response to the first antigen. Immunology, 115(1), 34-41. [More Information]
  • Grech, A., Gardam, S., Chan, T., Quinn, R., Gonzales, R., Basten, A., Brink, R. (2005). Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site. Journal of Biological Chemistry, 280(36), 31572-81. [More Information]
  • Phan, T., Paus, D., Chan, T., Gardam, S., Amesbury, M., Crosbie, J., Basten, A., Brink, R. (2005). Visualising B Cell Responses to Protein Antigens of Varying Affinity in Vivo. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.

2004

  • Thien, M., Phan, T., Gardam, S., Amesbury, M., Basten, A., Mackay, F., Brink, R. (2004). Excess Baff Rescues Self-Reactive B Cells From Peripheral Deletion And Allows Them To Enter Forbidden Follicular And Marginal Zone Niches. Immunity, 20(6), 785-798. [More Information]
  • Grech, A., Amesbury, M., Chan, T., Gardam, S., Basten, A., Brink, R. (2004). Traf2 Differentially Regulates The Canonical And Noncanonical Pathways Of Nf-Kappab Activation In Mature B Cells. Immunity, 21(5), 629-642.

2003

  • Phan, T., Amesbury, M., Gardam, S., Crosbie, J., Hasbold, J., Hodgkin, P., Basten, A., Brink, R. (2003). B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells. The Journal of Experimental Medicine, 197(7), 845-860.
  • Sze, D., Brown, R., Yang, S., Gibson, J., Ho, J., Fazekas, B., Basten, A., Joshua, D. (2003). Prediction of high affinity class I-restricted multiple myeloma idiotype peptide epitopes. Leukemia and lymphoma, 44(9), 1557-1568.
  • Cook, A., Oganesian, L., Harumal, P., Basten, A., Brink, R., Jolly, C. (2003). Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. Journal of Immunology, 171(2003), 6456-6464.

2001

  • Sze, D., Giesajtis,, G., Brown, R., Raitakari, M., Gibson, J., Ho, J., Baxter, A., Fazekas, B., Basten, A., Joshua, D. (2001). Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8+Cd57+CD28- compartment. Blood, 98(9), 2817-2827.
  • Ho, J., Basten, A., Gibson, J., Joshua, D., Brown, R., Pelka, G. (2001). Illegitimate switch recombinations are present in approximately half of primary myeloma tumors, but do not relate to known prognostic indicators or survival. Blood, 97, 490-495.
  • Basten, A., Cook, M., Korner, H., Winkler, T., Sedgwick, J., Rolliinghoff, M. (2001). Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles. Immunology and Cell Biology, 79, 54-61.

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