Associate Professor Anuwat Dinudom

Associate Professor & NHMRC Senior Research Fellow Level D
Physiology, School of Medical Sciences

Telephone 9036 3317
Fax 9036 3316

Map

Selected grants

2011

  • Regulation of epithelial sodium channels by caveolin; Cook D, Dinudom A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Interaction between H5N1 and the respiratory epithelium; Cook D, Dinudom A; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Mechanisms of Nedd4/Nedd4-2-mediated regulation of the epithelial sodium channel; Cook D, Dinudom A, Kumar S; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Fluorimetric imaging equipment; Cook D, Dinudom A; Clive & Vera Ramaciotti Foundation/Research Grant.
  • SRF Level A; Dinudom A; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

2003

  • Novel ways of regulating epithelial transport; Cook D, Young J, Dinudom A; Australian Research Council (ARC)/Discovery Projects (DP).
  • Regulation of the epithelial sodium channel by cytosolic chloride and proinflammatory cytokines?; Dinudom A, Cook D, Young J; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Patch-clamp micromanipulator; Dinudom A; Australian Kidney Foundation/Research Grant.
  • Equipment for studying sodium transport in epithelia; Dinudom A; Clive & Vera Ramaciotti Foundation/Research Grants.

2000

  • Feedback regulation of sodium-dependent transporters; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

Selected publications

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Journals

  • Campbell, C., Voyles, J., Cook, D., Dinudom, A. (2012). Frog skin epithelium: Electrolyte transport and chytridiomycosis. The International Journal of Biochemistry and Cell Biology, 44(3), 431-434. [More Information]
  • Lam, Y., Ha, C., Campbell, C., Mitchell, A., Dinudom, A., Oscarsson, J., Cook, D., Hunt, N., Caterson, I., Holmes, A., Storlien, L. (2012). Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-induced Obese Mice. PLoS One, 7(3), 1-10. [More Information]
  • Hee, L., Dinudom, A., Mitchell, A., Grau, G., Cook, D., Hunt, N., Ball, H. (2011). Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. International Journal for Parasitology, 41(1), 81-88. [More Information]
  • Lee, I., Song, S., Campbell, C., Kumar, S., Cook, D., Dinudom, A. (2011). Regulation of the Epithelial Na+ Channel by the RH-Domain of G Protein-coupled Receptor Kinase, GRK2, and Gαq/11. Journal of Biological Chemistry, 286(22), 19259-19269. [More Information]
  • Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D., et al (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9. [More Information]
  • Pholpramool, C., Borwornpinyo, S., Dinudom, A. (2011). Role of Na(+) /H(+) exchanger 3 (NHE3) in acidification of male reproductive tract and male fertility. Clinical and Experimental Pharmacology and Physiology, 38(7), 353-359. [More Information]
  • Hu, H., O'Mullane, L., Cummins, M., Campbell, C., Hosoda, Y., Poronnik, P., Dinudom, A., Cook, D. (2010). Negative regulation of Ca2+ influx during P2Y2 purinergic receptor activation is mediated by Gβγ-subunits. Cell Calcium, 47(1), 55-64. [More Information]
  • Voyles, J., Young, S., Berger, L., Campbell, C., Voyles, W., Dinudom, A., Cook, D., Webb, R., Alford, R., Skerratt, L., et al (2009). Pathogenesis of chytridiomycosis, a cause of catastrophic amphibian declines. Science, 326(5952), 582-585. [More Information]
  • O'Mullane, L., Cook, D., Dinudom, A. (2009). Purinergic regulation of the epithelial Na+ channel. Clinical and Experimental Pharmacology and Physiology, 36(10), 1016-1022. [More Information]
  • Lee, I., Campbell, C., Song, S., Day, M., Kumar, S., Cook, D., Dinudom, A. (2009). The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. Journal of Biological Chemistry, 284(19), 12663-12669. [More Information]
  • Lee, I., Campbell, C., Cook, D., Dinudom, A. (2008). Regulation of epithelial Na+ channels by aldosterone: role of Sgk1. Clinical and Experimental Pharmacology and Physiology, 35(2), 235-241. [More Information]
  • Wielpuetz, M., Lee, I., Dinudom, A., Boulkroun, S., Farman, N., Cook, D., Korbmacher, C., Rauh, R. (2007). (NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells. Journal of Biological Chemistry, 282(38), 28264-28273.
  • Lee, I., Dinudom, A., Sanchez-Perez, A., Kumar, S., Cook, D. (2007). Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Journal of Biological Chemistry, 282(41), 29866-29873. [More Information]
  • Rauh, R., Dinudom, A., Fotia, A., Paulides, M., Kumar, S., Korbmacher, C., Cook, D. (2006). Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pfluegers Archiv: European journal of physiology, 452(3), 290-299. [More Information]
  • Dinudom, A., Fotia, A., Lefkowitz, R., Young, J., Kumar, S., Cook, D. (2004). The Kinase Grk2 Regulates Nedd4/Nedd4-2-Dependent Control Of Epithelial Na+ Channels. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 101(32), 11886-11890.
  • Fotia, A., Dinudom, A., Shearwin, K., Koch, J., Korbmacher, C., Cook, D., Kumar, S. (2003). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. The F A S E B Journal, 17(1), 70-72.
  • Fotia, A., Dinudom, A., Shearwin, K., Koch, J., Korbacher, C., Cook, D., Kumar, S. (2002). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. The F A S E B Journal, 10(1), 1-22.
  • Dinudom, A., Komwatana, P., Young, J., Cook, D., Harvey, K., Jolliffe, C., Kumar, S. (2001). Roles of the C Termini of alpha, beta and subunits of epithelial Na+ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na+. Journal of Biological Chemistry, 276, 13744-13749.
  • Dinudom, A., Cook, D., Harvey, K., Kumar, S. (2001). The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. Journal of Biological Chemistry, 276, 8597-8601.

2012

  • Campbell, C., Voyles, J., Cook, D., Dinudom, A. (2012). Frog skin epithelium: Electrolyte transport and chytridiomycosis. The International Journal of Biochemistry and Cell Biology, 44(3), 431-434. [More Information]
  • Lam, Y., Ha, C., Campbell, C., Mitchell, A., Dinudom, A., Oscarsson, J., Cook, D., Hunt, N., Caterson, I., Holmes, A., Storlien, L. (2012). Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-induced Obese Mice. PLoS One, 7(3), 1-10. [More Information]

2011

  • Hee, L., Dinudom, A., Mitchell, A., Grau, G., Cook, D., Hunt, N., Ball, H. (2011). Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. International Journal for Parasitology, 41(1), 81-88. [More Information]
  • Lee, I., Song, S., Campbell, C., Kumar, S., Cook, D., Dinudom, A. (2011). Regulation of the Epithelial Na+ Channel by the RH-Domain of G Protein-coupled Receptor Kinase, GRK2, and Gαq/11. Journal of Biological Chemistry, 286(22), 19259-19269. [More Information]
  • Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D., et al (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9. [More Information]
  • Pholpramool, C., Borwornpinyo, S., Dinudom, A. (2011). Role of Na(+) /H(+) exchanger 3 (NHE3) in acidification of male reproductive tract and male fertility. Clinical and Experimental Pharmacology and Physiology, 38(7), 353-359. [More Information]

2010

  • Hu, H., O'Mullane, L., Cummins, M., Campbell, C., Hosoda, Y., Poronnik, P., Dinudom, A., Cook, D. (2010). Negative regulation of Ca2+ influx during P2Y2 purinergic receptor activation is mediated by Gβγ-subunits. Cell Calcium, 47(1), 55-64. [More Information]

2009

  • Voyles, J., Young, S., Berger, L., Campbell, C., Voyles, W., Dinudom, A., Cook, D., Webb, R., Alford, R., Skerratt, L., et al (2009). Pathogenesis of chytridiomycosis, a cause of catastrophic amphibian declines. Science, 326(5952), 582-585. [More Information]
  • O'Mullane, L., Cook, D., Dinudom, A. (2009). Purinergic regulation of the epithelial Na+ channel. Clinical and Experimental Pharmacology and Physiology, 36(10), 1016-1022. [More Information]
  • Lee, I., Campbell, C., Song, S., Day, M., Kumar, S., Cook, D., Dinudom, A. (2009). The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. Journal of Biological Chemistry, 284(19), 12663-12669. [More Information]

2008

  • Lee, I., Campbell, C., Cook, D., Dinudom, A. (2008). Regulation of epithelial Na+ channels by aldosterone: role of Sgk1. Clinical and Experimental Pharmacology and Physiology, 35(2), 235-241. [More Information]

2007

  • Wielpuetz, M., Lee, I., Dinudom, A., Boulkroun, S., Farman, N., Cook, D., Korbmacher, C., Rauh, R. (2007). (NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells. Journal of Biological Chemistry, 282(38), 28264-28273.
  • Lee, I., Dinudom, A., Sanchez-Perez, A., Kumar, S., Cook, D. (2007). Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Journal of Biological Chemistry, 282(41), 29866-29873. [More Information]

2006

  • Rauh, R., Dinudom, A., Fotia, A., Paulides, M., Kumar, S., Korbmacher, C., Cook, D. (2006). Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pfluegers Archiv: European journal of physiology, 452(3), 290-299. [More Information]

2004

  • Dinudom, A., Fotia, A., Lefkowitz, R., Young, J., Kumar, S., Cook, D. (2004). The Kinase Grk2 Regulates Nedd4/Nedd4-2-Dependent Control Of Epithelial Na+ Channels. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 101(32), 11886-11890.

2003

  • Fotia, A., Dinudom, A., Shearwin, K., Koch, J., Korbmacher, C., Cook, D., Kumar, S. (2003). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. The F A S E B Journal, 17(1), 70-72.

2002

  • Fotia, A., Dinudom, A., Shearwin, K., Koch, J., Korbacher, C., Cook, D., Kumar, S. (2002). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. The F A S E B Journal, 10(1), 1-22.

2001

  • Dinudom, A., Komwatana, P., Young, J., Cook, D., Harvey, K., Jolliffe, C., Kumar, S. (2001). Roles of the C Termini of alpha, beta and subunits of epithelial Na+ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na+. Journal of Biological Chemistry, 276, 13744-13749.
  • Dinudom, A., Cook, D., Harvey, K., Kumar, S. (2001). The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. Journal of Biological Chemistry, 276, 8597-8601.

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