Associate Professor Jonathon Arnold

Associate Professor
Pharmacology, School of Medical Sciences
Bosch Institute

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9036 5361
F: +61 2 9351 7328

Biographical details

Research interests

A/Prof Arnold has isolated genes that modulate the neurobehavioural effects of cannabinoids. His research has focussed on ABC transporter genes that encode drug efflux pumps found at the blood brain barrier. These might regulate cannabinoid brain uptake by transporting cannabinoid drugs from brain tissue back into the peripheral blood supply. His group was the first to show cannabinoids modulate activity and expression ofABCB1in 2006 (published inBiochemical Pharmacology) andABCG2in 2007 (published in theBritish Journal of Pharmacology). In recognition of this research A/Prof Arnold received a Young Investigator Award from the US-basedBrain and Behavior Research Foundation(formerly known as NARSAD). The other major arm of his research demonstrated that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the neuropharmacological actions of cannabinoids. The seminal manuscripts on this topic published in 2007 inPsychopharmacologyandNeurosciencehave received collectively over 100 citations. His research has influenced human genomic research in psychiatry, for example, a recently accepted publication inBiological Psychiatryfrom researchers at Yale University reported thatNRG1increased the risk of developing cannabis dependence. His recent publication in theInternational Journal of Neuropsychopharmacologyis the first to showNrg1is involved in the development of cannabinoid tolerance. In 2009 Dr Arnold established a Neurobehavioural Laboratory at the Brain and Mind Research Institute (BMRI) in collaboration with Professor Max Bennett.

International links

France. (University of Bordeaux) Collaboration with Prof Jacques Micheau on the effects on cannabinoids on cognition..
Iran. (Babol Medical Science University) Collaboration with Dr Ibrahim Zabihi.