Associate Professor Jonathon Arnold

Associate Professor
Pharmacology, School of Medical Sciences
Bosch Institute

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9036 5361
F: +61 2 9351 7328
E:

Biographical details

Dr Arnold is a Senior Lecturer at the University of Sydney and has over 15 years experience in behavioural neuroscience and pharmacology. He has published 36 manuscripts in peer-reviewed journals and has received 612 career citations (his publications prior to 2011 have received on average 28 citations per manuscript, h-index = 14). He completed his PhD on the neural and behavioural effects of cannabinoids (cannabis-like drugs) under Professor Iain McGregor at the University of Sydney in 2001. During his PhD Dr Arnold became fascinated by how genetic disposition influences the neurobehavioural actions of cannabinoids - understanding which genes affect cannabinoid action might help explain why certain individuals are more prone to mental disorders such as addiction or schizophrenia.
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Research interests

Dr Arnold has isolated genes that modulate the neurobehavioural effects of cannabinoids. His research has focussed on ABC transporter genes that encode drug efflux pumps found at the blood brain barrier. These might regulate cannabinoid brain uptake by transporting cannabinoid drugs from brain tissue back into the peripheral blood supply. His group was the first to show cannabinoids modulate activity and expression ofABCB1in 2006 (published inBiochemical Pharmacology) andABCG2in 2007 (published in theBritish Journal of Pharmacology). In recognition of this research Dr Arnold received a Young Investigator Award from the US-basedBrain and Behavior Research Foundation(formerly known as NARSAD). The other major arm of his research demonstrated that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the neuropharmacological actions of cannabinoids. The seminal manuscripts on this topic published in 2007 inPsychopharmacologyandNeurosciencehave received collectively 88 citations. His research has influenced human genomic research in psychiatry, for example, a recently accepted publication inBiological Psychiatryfrom researchers at Yale University reported thatNRG1increased the risk of developing cannabis dependence. His recent publication in theInternational Journal of Neuropsychopharmacologyis the first to showNrg1is involved in the development of cannabinoid tolerance. In 2009 Dr Arnold established a Neurobehavioural Laboratory at the Brain and Mind Research Institute (BMRI) in collaboration with Professor Max Bennett.

Teaching areas

For the last 8 years Dr Arnold has convened the 2ndyear Pharmacology unit of study, Pharmacology: Drugs and People at the University of Sydney.

International links

France. (University of Bordeaux) Collaboration with Prof Jacques Micheau on the effects on cannabinoids on cognition..
Iran. (Babol Medical Science University) Collaboration with Dr Ibrahim Zabihi.