Professor Barbara Fazekas de St Groth

BSc(Med) MBBS PhD
Professor, Discipline of Pathology, School of Medical Sciences, Sydney Medical School
Academic Director, Ramaciotti Facility for Human Systems Biology, The University of Sydndey

Member of the Charles Perkins Centre

Telephone +61 2 86275783

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Biographical details

Professor Fazekas de St Groth began her academic life as a maths and physics undergraduate at ANU. She went on to complete her BSc(Med) MBBS at the University of Sydney and worked as a Professorial Intern and Resident at Royal Prince Alfred Hospital, Sydney before completing a PhD in the area of T lymphocyte biology with JFAP Miller at the Walter and Eliza Hall Institute in Melbourne. Subsequently she undertook postdoctoral training with Mark Davis at Stanford University where she developed the first T cell receptor transgenic mouse model for the analysis of CD4 T cell responses in vivo and published landmark papers describing thymic positive and negative selection of CD4 T cells. She returned to Sydney on a CJ Martin Fellowship and became a founding member of the Centenary Institute, setting up the T cell biology lab where she established an international reputation for her work using T cell receptor transgenic mouse models and multiparameter flow cytometry to define fundamental immune processes, including those involved in allergy, autoimmunity and cancer. Her studies on the role of regulatory T cells in mice and humans included the discovery of the gold-standard phenotyping strategy that allows pure populations of human regulatory T cells to be isolated and manipulated for immunotherapy. In 2016, she was appointed a Professor in the Discipline of Pathology at the University of Sydney, where she is the Director of the Ramaciotti Facility for Human Systems Biology. The Ramaciotti Facility commissioned the first CyTOF II mass cytometry platform in Australia, a breakthrough technology that greatly speeds up the pace of cytometry-based protein measurement at the single cell level. Since 2016, the Ramaciotti Facility has upgraded to the Helios platform and installed the first Hyperion mass imaging platform in the Southern Hemisphere. Professor Fazekas de St Groth’s current research involves the use of highly multi-parametric mass cytometry to define immune signatures that predict individual patient disease profiles and responses to cancer immunotherapy.

Research interests

“My work involves understanding how basic immune functions contribute to a range of human conditions in the areas of transplantation, cancer, allergy and autoimmunity. I am currently developing mass cytometry technology to identify immune signatures that predict individual patient disease profiles and responses to therapy. One hope is that this will enable me to develop a blood test that will predict cancer patient response to checkpoint therapy, thus saving considerable expense and suffering from wasted therapies.

“My 5 year aims are to develop new insights into immune regulation in clinical and preclincal settings, and to help the University of Sydney to bring immune signature analysis into the clinic as a novel decision-making tool in rheumatology, cancer immunotherapy and renal transplantation. I will build up the team within the Ramaciotti Facility, strengthening collaborations within the University and nationally, forging international links in mass cytometry, bioinformatics and systems biology, and developing further commercial links in clinical trial monitoring.”

Current projects

I have 2 research topics that may be are relevant to collaborations between Sydney Medical School and Engineering and IT.

1) development of computational methods and pipelines for the analysis of mass cytometry data from individuals and its integration with other data sources (clinical, ‘omics’ etc) to bring personalized medicine closer to reality.

2) development of new technologies for application to mass cytometry (methods for more efficient metal conjugation to antibodies, nanoparticles for applications in mass cytometry etc).

Selected grants

2018

  • The Ramaciotti Centre for Human Systems Biology; Fazekas de St Groth B, King N; Clive & Vera Ramaciotti Foundation/Biomedical Research Award.
  • High-throughput Portable and Wearable Device Fabrication Facility; Jin D, Fazekas de St Groth B, Zreiqat H; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Predicting response to checkpoint therapy in lung cancer patients; Fazekas de St Groth B; MRFF � Medical Research Future Fund/Dept of Health (Federal) - Rapid Applied Research Translation (RART).
  • Predicting responses to cancer immunotherapy; Fazekas de St Groth B, Kao S; Cancer Council New South Wales/Program Grant.
  • Regulatory T cell therapy for prevention of graft versus host disease; Fazekas de St Groth B, Hart D, Bolton H, McGuire H; National Health and Medical Research Council (NHMRC)/Project Grants.

2017

  • Determinants of response to immune checkpoint inhibitors in melanoma; Rizos H, Long G, Fazekas de St Groth B, Menzies A; National Health and Medical Research Council (NHMRC)/Project Grants.

2016

  • CyTOF2.1 Upgrade Package to Helios System Capability; King N, Fazekas de St Groth B, Hart D, Booth D, Charles (nee Slaviero) K; University of Sydney/Equipment Grant.
  • Development of a New Specific Immunosuppressive Monoclonal Antibody to Advance Transplantation; Hogarth P, Clark G, Gray P, Fazekas de St Groth B, Larsen S, Gottlieb D, Alexander S, Hennessy A, Hart D; National Health and Medical Research Council (NHMRC)/Development Grants.

2015

  • Characterising splenic myeloid responses to CNS pathogens; Mitchell A, Grau G, Fazekas de St Groth B, King N, Palendira U; University of Sydney/Internal Scheme.
  • The Sydney 1000 Cancer Project – Stage 1 Gastrointestinal Cancers Immunophenotyping Study; Charles (nee Slaviero) K, Clarke S, Diakos C, Pavlakis N, Engel A, Samra J, Gill A, Kneebone A, Fazekas de St Groth B, Hart D, Smith A, Byrne S, McGuire H, Vafaee F, King M; DVC Research/SPARC Implementation - Cancer.

2014

  • A CyTOF for the NSW Advanced Cytometry Facility - clean multidimensional multiparametric flow cytometry using single cell mass spectrometry; King N, Campbell I, Fazekas de St Groth B, Cordwell S, Rendina L, Gunning P, Crossley M, Davenport M, Hogg P, Pimanda J, Goldys E, Jin D, Molloy M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Towards real time data sharing to support patient-centred care, quality health delivery, improvement programmes, performance management and research; Morris J, Roberts C, Simpson S, Kay J, Venkatesh S, Fazekas de St Groth B, Arthur J, Feng D, Holmes E, James D, Yang J, Engel A; NSW Ministry of Health, Office for Health and Medical Research/Bioinformatics Collaborative Grants Program.

2013

  • CyTOF Mass Cytometry Platform; Fazekas de St Groth B, Weninger W, Richardson D, Halliday G, Gunning P, Hart D, Mann G, Goldys E, Jin D; Cancer Institute New South Wales/Equipment Grant.
  • Dendritic cell-mediated induction of T cell tolerance; Fazekas de St Groth B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas de St Groth B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Defining defects in antiviral immunity in the aged; Ertl H, Fazekas de St Groth B, Weninger W; National Institutes of Health (USA)/Research Support.

2011

  • Strategies to enhance CD4 T cell-mediated anti-tumour immunity; Fazekas de St Groth B, Shklovskaya E; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms of islet graft rejection and acceptance; Fazekas de St Groth B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Control of allergic lung inflammation; Fazekas de St Groth B; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • High speed 3D live cell imaging of cancer genesis, growth, metastasis and death.; Weninger W, Vadas M, Richardson D, Fazekas de St Groth B, Gamble J, McCaughan G, Rasko J, Shackel N, Haass N; Cancer Institute New South Wales/Equipment Grant.
  • NHMRC Principal Research Fellowship; Fazekas de St Groth B; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Next generation high speed cell sorter for cytometry and imaging facility; Fazekas de St Groth B; Cancer Institute New South Wales/Infrastructure Grant.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas de St Groth B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.
  • The role of primed T cells in graft rejection; Fazekas de St Groth B, Alexander S, Levidiotis V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • 7-laser BD LSR-II and Cellomics Array Scan VTi to Enhance Capability and Throughput for the NSW Advanced Cytometry Facility; King N, Weninger W, Gunning P, Fazekas de St Groth B, Campbell I, Christopherson R, Black J, Mason R, Richardson D, Halliday G, Grau G, Gandevia S, Kachigian L, Geczy C, Jessup W, Vadas M, Britton W, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Real-time imaging of the initiation of adaptive immunity in vivo; Fazekas de St Groth B, Weninger W; Australian Research Council (ARC)/Discovery Projects (DP).
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • 800 MHz NMR spectrometer for biomolecular structure-function analysis; Mackay J, Otting G, Kuchel P, Matthews J, Gell D, Trewhella J, Rutledge P, Messerle B, Vadas M, Graham R, Vandenberg J, Stock D, Ball G, Fazekas de St Groth B, Shine J; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • 800 MHz NMR spectrometer for biomolecular structure function analysis; Vadas M, Stock D, Graham R, Shine J, Ball G, Matthews J, Gell D, Trewhella J, Rutledge P, Messerle B, Fazekas de St Groth B, Vandenberg J, Mackay J, Otting G, Kuchel P; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • Molecular and cellular studies of the adaptive immune response in health and disease; Mackay C, Fazekas de St Groth B; National Health and Medical Research Council (NHMRC)/Program Grants.
  • Centenary institute of cancer medicine and cell biology: Expert microinjection technologist for creating genetically modified mice; Fazekas de St Groth B; Cancer Institute New South Wales/Research Grant.

2006

  • Cancer Institute NSW - Infrastructure Grant; Fazekas de St Groth B; Cancer Institute New South Wales/Research Grants.

2005

  • Research Fellowship; Fazekas de St Groth B; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

2004

  • Verdi V2 DPSS laser system; Fazekas de St Groth B, Rasko J, Britton W, Tangye S, Brink R, Basten A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Cellular and molecular studies of the adaptive immune response in health and disease; Basten A, Fazekas de St Groth B, Brink R, Tangye S, Mackay F; National Health and Medical Research Council (NHMRC)/Program Grants.

2000

  • The role of dendritic cell subsets in the decision between T cell tolerance and immunity; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

Selected publications

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Book Chapters

  • Fazekas de St Groth, B., Zhu, E., Asad, S., Lee, L. (2011). Flow Cytometric Detection of Human Regulatory T Cells. In George Kassiotis; Adrian Liston (Eds.), Methods in Molecular Biology - Regulatory T Cells: Methods and Protocols, (pp. 263-279). New York, United States of America: Humana Press. [More Information]

Journals

  • Hsu, J., Bryant, C., Papadimitrious, M., Kong, B., Gasiorowski, R., Orellana, D., McGuire, H., Fazekas de St Groth, B., Joshua, D., Ho, P., Iland, H., Gibson, J., Clark, G., Fromm, P., Hart, D., et al (2018). A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission. OncoImmunology, 7(4), e1419114-1-e1419114-11. [More Information]
  • McGuire, H., Shklovskaya, E., Edwards, J., Trevillian, P., McCaughan, G., Bertolino, P., McKenzie, C., Gourlay, R., Gallagher, S., Fazekas de St Groth, B., Hersey, P. (2018). Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report. Cancer Immunology, Immunotherapy, 67(4), 563-573. [More Information]
  • Kaur, S., Sehgal, R., Shastry, S., McCaughan, G., McGuire, H., Fazekas de St Groth, B., Sarin, S., Trehanpati, N., Seth, D. (2018). Circulating endothelial progenitor cells present an inflammatory phenotype and function in patients with alcoholic liver cirrhosis. Frontiers in Physiology, 9, 1-10. [More Information]
  • Stern, L., McGuire, H., Avdic, S., Rizzetto, S., Fazekas de St Groth, B., Luciani, F., Slobedman, B., Blyth, E. (2018). Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 9, 1-18. [More Information]
  • Lomax, A., McGuire, H., McNeil, C., Choi, C., Hersey, P., Karikios, D., Shannon, K., Van Hal, S., Carr, U., Crotty, A., Hollingsworth, J., Kim, H., Fazekas de St Groth, B., McGill, N., et al (2017). Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic analysis. International Journal of Rheumatic Diseases, 20(9), 1277-1285. [More Information]
  • Tong, P., West, N., Cox, A., Gebski, V., Watts, A., Dodds, A., Fazekas de St Groth, B., Cripps, A., Shumack, S. (2017). Oral supplementation with bovine whey-derived Ig-rich fraction and lactoferrin improves SCORAD and DLQI in atopic dermatitis. Journal of Dermatological Science, 85(2), 143-146. [More Information]
  • Guy, T., Terry, A., Bolton, H., Hancock, D., Zhu, E., Brink, R., McGuire, H., Shklovskaya, E., Fazekas de St Groth, B. (2016). Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity. Oncotarget, 7(21), 30211-30229. [More Information]
  • Tiffen, J., Gallagher, S., Tseng, H., Filipp, F., Fazekas de St Groth, B., Hersey, P. (2016). EZH2 as a mediator of treatment resistance in melanoma. Pigment Cell & Melanoma Research, 29(5), 500-507. [More Information]
  • Guy, T., Terry, A., Bolton, H., Hancock, D., Shklovskaya, E., Fazekas de St Groth, B. (2016). Pro- and anti-tumour effects of B cells and antibodies in cancer: a comparison of clinical studies and preclinical models. Cancer Immunology, Immunotherapy, 65(8), 885-896. [More Information]
  • West, N., Horn, P., Pyne, D., Warren, H., Asad, S., Cox, A., Lahtinen, S., Lehtinen, M., Fricker, P., Cripps, A., Fazekas de St Groth, B. (2016). Probiotic supplementation has little effect on peripheral blood regulatory T�cells. Journal of Allergy and Clinical Immunology, 138(6), 1749-1.75E+10. [More Information]
  • Bolton, H., Fazekas de St Groth, B. (2016). Reconstitution of Lymphopaenic Mice with Regulatory and Conventional T Cell Subsets. Bio-protocol, 6(10), 1-9.
  • Ju, X., Silveira, P., Hsu, W., Elgundi, Z., Alingcastre, R., Verma, N., Fromm, P., Hsu, J., Bryant, C., Li, Z., Lo, T., Lee, K., Fazekas de St Groth, B., Larsen, S., Gibson, J., Bradstock, K., Clark, G., Hart, D., et al (2016). The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population. Journal of Immunology, 197(12), 4613-4625. [More Information]
  • Shklovskaya, E., Terry, A., Guy, T., Buckley, A., Bolton, H., Zhu, E., Holst, J., Fazekas de St Groth, B. (2016). Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen. Immunology and Cell Biology, 94(6), 593-603. [More Information]
  • Roediger, B., Kyle, R., Tay, S., Mitchell, A., Bolton, H., Guy, T., Tan, S., Forbes-Blom, E., Tong, P., Koller, Y., Shklovskaya, E., Fazekas de St Groth, B., Weninger, W., et al (2015). IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation. Journal of Allergy and Clinical Immunology, 136(6), 1653-1663e7. [More Information]
  • Bolton, H., Zhu, E., Terry, A., Guy, T., Koh, W., Tan, S., Power, C., Bertolino, P., Lahl, K., Sparwasser, T., Shklovskaya, E., Fazekas de St Groth, B. (2015). Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. Journal of Clinical Investigation, 125(9), 3627-3641. [More Information]
  • Bolton, H., Roediger, B., Fazekas de St Groth, B. (2015). The effects of IL-2 and Treg cells on dendritic cell homeostasis are mediated indirectly via activation of conventional T cells. European Journal of Immunology, 45(4), 1141-1147. [More Information]
  • Hancock, D., Shklovskaya, E., Guy, T., Falsafi, R., Fjell, C., Ritchie, W., Hancock, R., Fazekas de St Groth, B. (2014). A Systems Biology Approach to the Analysis of Subset-Specific Responses to Lipopolysaccharide in Dendritic Cells. PloS One, 9(6), 1-16. [More Information]
  • Ochiai, S., Roediger, B., Abtin, A., Shklovskaya, E., Fazekas de St Groth, B., Yamane, H., Weninger, W., Le Gros, G., Ronchese, F. (2014). CD326(lo)CD103(lo)CD11b(lo) Dermal Dendritic Cells are Activated by Thymic Stromal Lymphopoietin during Contact Sensitization in Mice. Journal of Immunology, 193(5), 2504-2511. [More Information]
  • Roediger, B., Kyle, R., Yip, K., Sumaria, N., Guy, T., Kim, B., Mitchell, A., Tay, S., Jain, R., Forbes-Blom, E., Tong, P., Fazekas de St Groth, B., Weninger, W., et al (2013). Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nature Immunology, 14(6), 564-573. [More Information]
  • Hancock, D., Guy, T., Shklovskaya, E., Fazekas de St Groth, B. (2013). Experimental models to investigate the function of dendritic cell subsets: Challenges and implications. Clinical and Experimental Immunology, 171(2), 147-154. [More Information]
  • Tan, S., Cavanagh, L., d’Advigor, W., Shackel, N., Fazekas de St Groth, B., Weninger, W. (2012). Phenotype and functions of conventional dendritic cells are not compromised in aged mice. Immunology and Cell Biology, 90(7), 722-732. [More Information]
  • Fazekas de St Groth, B. (2012). Regulatory T-cell abnormalities and the global epidemic of immuno-inflammatory disease. Immunology and Cell Biology, 90(3), 256-259. [More Information]
  • Sumaria, N., Roediger, B., Ng, L., Qin, J., Pinto, R., Cavanagh, L., Shklovskaya, E., Fazekas de St Groth, B., Triccas, J., Weninger, W. (2011). Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells. The Journal of Experimental Medicine, 208(3), 505-518. [More Information]
  • O'Sullivan, B., Pai, S., Street, S., An, X., MacDonald, K., Wong, M., Strutton, G., Gerondakis, S., Steptoe, R., Fazekas de St Groth, B., et al (2011). Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation. Journal of Immunology, 187(8), 4018-4030. [More Information]
  • Shklovskaya, E., O'Sullivan, B., Ng, L., Roediger, B., Thomas, R., Weninger, W., Fazekas de St Groth, B. (2011). Langerhans cells are precommitted to immune tolerance induction. Proceedings of the National Academy of Sciences of the United States of America, 108(44), 18049-18054. [More Information]
  • Ryan, A., Nambiar, J., Wozniak, T., Roediger, B., Shklovskaya, E., Britton, W., Fazekas de St Groth, B., Triccas, J. (2009). Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection. Journal of Immunology, 182(11), 7172-7177. [More Information]
  • Santner-Nanan, B., Peek, M., Khanam, R., Richarts, L., Zhu, E., Fazekas de St Groth, B., Nanan, R. (2009). Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. Journal of Immunology, 183(11), 7023-7030. [More Information]
  • Nanan, B., Seddiki, N., Zhu, E., Quent, V., Kelleher, A., Fazekas de St Groth, B., Nanan, R. (2008). Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype. International Immunology, 20(3), 375-383. [More Information]
  • Shklovskaya, E., Roediger, B., Fazekas de St Groth, B. (2008). Epidermal and dermal dendritic cells display differential activation and migratory behavior while sharing the ability to stimulate CD4+ T cell proliferation in vivo. Journal of Immunology, 181(1), 418-430. [More Information]
  • Fazekas de St Groth, B., Landay, A. (2008). Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response? AIDS, 22(6), 671-683.
  • Basten, A., Fazekas de St Groth, B. (2008). Special regulatory T-cell review: T-cell dependent suppression revisited. Immunology, 123, 33-39. [More Information]
  • Roediger, B., Ng, L., Smith, A., Fazekas de St Groth, B., Weninger, W. (2008). Visualizing dendritic cell migration within the skin. Histochemistry and Cell Biology, 130(6), 1131-1146. [More Information]
  • Shklovskaya, E., Fazekas de St Groth, B. (2007). Balancing tolerance and immunity: the role of dendritic cell and T cell subsets. Methods in Molecular Biology (Clifton N.J.), 380, 25-46. [More Information]
  • Triccas, J., Shklovskaya, E., Spratt, J., Ryan, A., Palindera, U., Fazekas de St Groth, B., Britton, W. (2007). Effects of DNA- and Mycobacterium bovis BCG-based delivery of Flt3 ligand on protective immunity to Mycobacterium tuberculosis. Infection and Immunity, 75(11), 5368-5375. [More Information]
  • Ryan, A., Wozniak, T., Shklovskaya, E., O'Donnell, M., Fazekas de St Groth, B., Britton, W., Triccas, J. (2007). Improved protection against disseminated tuberculosis by Mycobacterium bovis bacillus Calmette-Guerin secreting murine GM-CSF Is associated with expansion and activation of APCs. Journal of Immunology, 179(12), 8418-8424. [More Information]
  • Fazekas de St Groth, B. (2007). Regulatory T-cell function: When suppressor cells can't suppress. Immunology and Cell Biology, 85(3), 179-181. [More Information]
  • Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S., Nanan, R., Fazekas de St Groth, B., et al (2006). Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. The Journal of Experimental Medicine, 203(7), 1693-1700. [More Information]
  • Seddiki, N., Nanan, B., Tangye, S., Alexander, S., Solomon, M., Soon, L., Nanan, R., Fazekas de St Groth, B. (2006). Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood, 107(7), 2830-2838. [More Information]
  • Shklovskaya, E., Fazekas de St Groth, B. (2006). Severely impaired clonal deletion of CD4+ T cells in low-dose irradiated mice: role of T cell antigen receptor and IL-7 receptor signals. Journal of Immunology, 177(12), 8320-8330. [More Information]
  • Gilbertson, B., Germano, S., Steele, P., Turner, S., Fazekas de St Groth, B., Cheers, C. (2004). Bystander Activation Of CD8+ T Lymphocytes During Experimental Mycobacterial Infection. Infection and Immunity, 72(12), 6884-6891. [More Information]
  • Van Maurik, A., Fazekas de St Groth, B., Wood, K., Jones, N. (2004). Dependency Of Direct Pathway CD4+ T Cells On CD40-CD154 Costimulation Is Determined By Nature And Microenvironment Of Primary Contact With Alloantigen. Journal of Immunology, 172(4), 2163-2170.
  • Fazekas de St Groth, B., Smith, A., Higgins, C. (2004). T Cell Activation: In Vivo Veritas. Immunology and Cell Biology, 82(3), 260-268. [More Information]
  • Sze, D., Brown, R., Yuen, E., Gibson, J., Ho, P., Raitakari, M., Basten, A., Joshua, D., Fazekas de St Groth, B. (2003). Clonal Cytotoxic T Cells in Myeloma. Leukemia and Lymphoma, 44(10), 1667-1674. [More Information]
  • Sze, D., Brown, R., Yang, S., Gibson, J., Ho, P., Fazekas de St Groth, B., Basten, A., Joshua, D. (2003). Prediction of high affinity class I-restricted multiple myeloma idiotype peptide epitopes. Leukemia and Lymphoma, 44(9), 1557-1568. [More Information]
  • Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas de St Groth, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264. [More Information]
  • Fazekas de St Groth, B., Smith, A., Bosco, J., Sze, D., Power, C., Austen, F. (2002). Experimental models linking dendritic cell lineage, phenotype and function. Immunology and Cell Biology, 80(5), 469-476. [More Information]
  • Bertolino, P., Bowen, D., McCaughan, G., Fazekas de St Groth, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.
  • Sze, D., Giesajtis,, G., Brown, R., Raitakari, M., Gibson, J., Ho, P., Baxter, A., Fazekas de St Groth, B., Basten, A., Joshua, D. (2001). Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8+Cd57+CD28- compartment. Blood, 98(9), 2817-2827.

Conferences

  • Fazekas de St Groth, B., Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Nanan, R., Kelleher, A. (2006). Expression of IL-2 and IL-7 receptors discriminates between human regulatory and activated T-cells within CD45RA and CD45RO compartments. Federation of Clinical Immunology Societies (FOCIS) Annual Meeting 2006, USA: Academic Press.

2018

  • Hsu, J., Bryant, C., Papadimitrious, M., Kong, B., Gasiorowski, R., Orellana, D., McGuire, H., Fazekas de St Groth, B., Joshua, D., Ho, P., Iland, H., Gibson, J., Clark, G., Fromm, P., Hart, D., et al (2018). A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission. OncoImmunology, 7(4), e1419114-1-e1419114-11. [More Information]
  • McGuire, H., Shklovskaya, E., Edwards, J., Trevillian, P., McCaughan, G., Bertolino, P., McKenzie, C., Gourlay, R., Gallagher, S., Fazekas de St Groth, B., Hersey, P. (2018). Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report. Cancer Immunology, Immunotherapy, 67(4), 563-573. [More Information]
  • Kaur, S., Sehgal, R., Shastry, S., McCaughan, G., McGuire, H., Fazekas de St Groth, B., Sarin, S., Trehanpati, N., Seth, D. (2018). Circulating endothelial progenitor cells present an inflammatory phenotype and function in patients with alcoholic liver cirrhosis. Frontiers in Physiology, 9, 1-10. [More Information]
  • Stern, L., McGuire, H., Avdic, S., Rizzetto, S., Fazekas de St Groth, B., Luciani, F., Slobedman, B., Blyth, E. (2018). Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 9, 1-18. [More Information]

2017

  • Lomax, A., McGuire, H., McNeil, C., Choi, C., Hersey, P., Karikios, D., Shannon, K., Van Hal, S., Carr, U., Crotty, A., Hollingsworth, J., Kim, H., Fazekas de St Groth, B., McGill, N., et al (2017). Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic analysis. International Journal of Rheumatic Diseases, 20(9), 1277-1285. [More Information]
  • Tong, P., West, N., Cox, A., Gebski, V., Watts, A., Dodds, A., Fazekas de St Groth, B., Cripps, A., Shumack, S. (2017). Oral supplementation with bovine whey-derived Ig-rich fraction and lactoferrin improves SCORAD and DLQI in atopic dermatitis. Journal of Dermatological Science, 85(2), 143-146. [More Information]

2016

  • Guy, T., Terry, A., Bolton, H., Hancock, D., Zhu, E., Brink, R., McGuire, H., Shklovskaya, E., Fazekas de St Groth, B. (2016). Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity. Oncotarget, 7(21), 30211-30229. [More Information]
  • Tiffen, J., Gallagher, S., Tseng, H., Filipp, F., Fazekas de St Groth, B., Hersey, P. (2016). EZH2 as a mediator of treatment resistance in melanoma. Pigment Cell & Melanoma Research, 29(5), 500-507. [More Information]
  • Guy, T., Terry, A., Bolton, H., Hancock, D., Shklovskaya, E., Fazekas de St Groth, B. (2016). Pro- and anti-tumour effects of B cells and antibodies in cancer: a comparison of clinical studies and preclinical models. Cancer Immunology, Immunotherapy, 65(8), 885-896. [More Information]
  • West, N., Horn, P., Pyne, D., Warren, H., Asad, S., Cox, A., Lahtinen, S., Lehtinen, M., Fricker, P., Cripps, A., Fazekas de St Groth, B. (2016). Probiotic supplementation has little effect on peripheral blood regulatory T�cells. Journal of Allergy and Clinical Immunology, 138(6), 1749-1.75E+10. [More Information]
  • Bolton, H., Fazekas de St Groth, B. (2016). Reconstitution of Lymphopaenic Mice with Regulatory and Conventional T Cell Subsets. Bio-protocol, 6(10), 1-9.
  • Ju, X., Silveira, P., Hsu, W., Elgundi, Z., Alingcastre, R., Verma, N., Fromm, P., Hsu, J., Bryant, C., Li, Z., Lo, T., Lee, K., Fazekas de St Groth, B., Larsen, S., Gibson, J., Bradstock, K., Clark, G., Hart, D., et al (2016). The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population. Journal of Immunology, 197(12), 4613-4625. [More Information]
  • Shklovskaya, E., Terry, A., Guy, T., Buckley, A., Bolton, H., Zhu, E., Holst, J., Fazekas de St Groth, B. (2016). Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen. Immunology and Cell Biology, 94(6), 593-603. [More Information]

2015

  • Roediger, B., Kyle, R., Tay, S., Mitchell, A., Bolton, H., Guy, T., Tan, S., Forbes-Blom, E., Tong, P., Koller, Y., Shklovskaya, E., Fazekas de St Groth, B., Weninger, W., et al (2015). IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation. Journal of Allergy and Clinical Immunology, 136(6), 1653-1663e7. [More Information]
  • Bolton, H., Zhu, E., Terry, A., Guy, T., Koh, W., Tan, S., Power, C., Bertolino, P., Lahl, K., Sparwasser, T., Shklovskaya, E., Fazekas de St Groth, B. (2015). Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. Journal of Clinical Investigation, 125(9), 3627-3641. [More Information]
  • Bolton, H., Roediger, B., Fazekas de St Groth, B. (2015). The effects of IL-2 and Treg cells on dendritic cell homeostasis are mediated indirectly via activation of conventional T cells. European Journal of Immunology, 45(4), 1141-1147. [More Information]

2014

  • Hancock, D., Shklovskaya, E., Guy, T., Falsafi, R., Fjell, C., Ritchie, W., Hancock, R., Fazekas de St Groth, B. (2014). A Systems Biology Approach to the Analysis of Subset-Specific Responses to Lipopolysaccharide in Dendritic Cells. PloS One, 9(6), 1-16. [More Information]
  • Ochiai, S., Roediger, B., Abtin, A., Shklovskaya, E., Fazekas de St Groth, B., Yamane, H., Weninger, W., Le Gros, G., Ronchese, F. (2014). CD326(lo)CD103(lo)CD11b(lo) Dermal Dendritic Cells are Activated by Thymic Stromal Lymphopoietin during Contact Sensitization in Mice. Journal of Immunology, 193(5), 2504-2511. [More Information]

2013

  • Roediger, B., Kyle, R., Yip, K., Sumaria, N., Guy, T., Kim, B., Mitchell, A., Tay, S., Jain, R., Forbes-Blom, E., Tong, P., Fazekas de St Groth, B., Weninger, W., et al (2013). Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nature Immunology, 14(6), 564-573. [More Information]
  • Hancock, D., Guy, T., Shklovskaya, E., Fazekas de St Groth, B. (2013). Experimental models to investigate the function of dendritic cell subsets: Challenges and implications. Clinical and Experimental Immunology, 171(2), 147-154. [More Information]

2012

  • Tan, S., Cavanagh, L., d’Advigor, W., Shackel, N., Fazekas de St Groth, B., Weninger, W. (2012). Phenotype and functions of conventional dendritic cells are not compromised in aged mice. Immunology and Cell Biology, 90(7), 722-732. [More Information]
  • Fazekas de St Groth, B. (2012). Regulatory T-cell abnormalities and the global epidemic of immuno-inflammatory disease. Immunology and Cell Biology, 90(3), 256-259. [More Information]

2011

  • Sumaria, N., Roediger, B., Ng, L., Qin, J., Pinto, R., Cavanagh, L., Shklovskaya, E., Fazekas de St Groth, B., Triccas, J., Weninger, W. (2011). Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells. The Journal of Experimental Medicine, 208(3), 505-518. [More Information]
  • Fazekas de St Groth, B., Zhu, E., Asad, S., Lee, L. (2011). Flow Cytometric Detection of Human Regulatory T Cells. In George Kassiotis; Adrian Liston (Eds.), Methods in Molecular Biology - Regulatory T Cells: Methods and Protocols, (pp. 263-279). New York, United States of America: Humana Press. [More Information]
  • O'Sullivan, B., Pai, S., Street, S., An, X., MacDonald, K., Wong, M., Strutton, G., Gerondakis, S., Steptoe, R., Fazekas de St Groth, B., et al (2011). Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation. Journal of Immunology, 187(8), 4018-4030. [More Information]
  • Shklovskaya, E., O'Sullivan, B., Ng, L., Roediger, B., Thomas, R., Weninger, W., Fazekas de St Groth, B. (2011). Langerhans cells are precommitted to immune tolerance induction. Proceedings of the National Academy of Sciences of the United States of America, 108(44), 18049-18054. [More Information]

2009

  • Ryan, A., Nambiar, J., Wozniak, T., Roediger, B., Shklovskaya, E., Britton, W., Fazekas de St Groth, B., Triccas, J. (2009). Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection. Journal of Immunology, 182(11), 7172-7177. [More Information]
  • Santner-Nanan, B., Peek, M., Khanam, R., Richarts, L., Zhu, E., Fazekas de St Groth, B., Nanan, R. (2009). Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. Journal of Immunology, 183(11), 7023-7030. [More Information]

2008

  • Nanan, B., Seddiki, N., Zhu, E., Quent, V., Kelleher, A., Fazekas de St Groth, B., Nanan, R. (2008). Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype. International Immunology, 20(3), 375-383. [More Information]
  • Shklovskaya, E., Roediger, B., Fazekas de St Groth, B. (2008). Epidermal and dermal dendritic cells display differential activation and migratory behavior while sharing the ability to stimulate CD4+ T cell proliferation in vivo. Journal of Immunology, 181(1), 418-430. [More Information]
  • Fazekas de St Groth, B., Landay, A. (2008). Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response? AIDS, 22(6), 671-683.
  • Basten, A., Fazekas de St Groth, B. (2008). Special regulatory T-cell review: T-cell dependent suppression revisited. Immunology, 123, 33-39. [More Information]
  • Roediger, B., Ng, L., Smith, A., Fazekas de St Groth, B., Weninger, W. (2008). Visualizing dendritic cell migration within the skin. Histochemistry and Cell Biology, 130(6), 1131-1146. [More Information]

2007

  • Shklovskaya, E., Fazekas de St Groth, B. (2007). Balancing tolerance and immunity: the role of dendritic cell and T cell subsets. Methods in Molecular Biology (Clifton N.J.), 380, 25-46. [More Information]
  • Triccas, J., Shklovskaya, E., Spratt, J., Ryan, A., Palindera, U., Fazekas de St Groth, B., Britton, W. (2007). Effects of DNA- and Mycobacterium bovis BCG-based delivery of Flt3 ligand on protective immunity to Mycobacterium tuberculosis. Infection and Immunity, 75(11), 5368-5375. [More Information]
  • Ryan, A., Wozniak, T., Shklovskaya, E., O'Donnell, M., Fazekas de St Groth, B., Britton, W., Triccas, J. (2007). Improved protection against disseminated tuberculosis by Mycobacterium bovis bacillus Calmette-Guerin secreting murine GM-CSF Is associated with expansion and activation of APCs. Journal of Immunology, 179(12), 8418-8424. [More Information]
  • Fazekas de St Groth, B. (2007). Regulatory T-cell function: When suppressor cells can't suppress. Immunology and Cell Biology, 85(3), 179-181. [More Information]

2006

  • Fazekas de St Groth, B., Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Nanan, R., Kelleher, A. (2006). Expression of IL-2 and IL-7 receptors discriminates between human regulatory and activated T-cells within CD45RA and CD45RO compartments. Federation of Clinical Immunology Societies (FOCIS) Annual Meeting 2006, USA: Academic Press.
  • Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S., Nanan, R., Fazekas de St Groth, B., et al (2006). Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. The Journal of Experimental Medicine, 203(7), 1693-1700. [More Information]
  • Seddiki, N., Nanan, B., Tangye, S., Alexander, S., Solomon, M., Soon, L., Nanan, R., Fazekas de St Groth, B. (2006). Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood, 107(7), 2830-2838. [More Information]
  • Shklovskaya, E., Fazekas de St Groth, B. (2006). Severely impaired clonal deletion of CD4+ T cells in low-dose irradiated mice: role of T cell antigen receptor and IL-7 receptor signals. Journal of Immunology, 177(12), 8320-8330. [More Information]

2004

  • Gilbertson, B., Germano, S., Steele, P., Turner, S., Fazekas de St Groth, B., Cheers, C. (2004). Bystander Activation Of CD8+ T Lymphocytes During Experimental Mycobacterial Infection. Infection and Immunity, 72(12), 6884-6891. [More Information]
  • Van Maurik, A., Fazekas de St Groth, B., Wood, K., Jones, N. (2004). Dependency Of Direct Pathway CD4+ T Cells On CD40-CD154 Costimulation Is Determined By Nature And Microenvironment Of Primary Contact With Alloantigen. Journal of Immunology, 172(4), 2163-2170.
  • Fazekas de St Groth, B., Smith, A., Higgins, C. (2004). T Cell Activation: In Vivo Veritas. Immunology and Cell Biology, 82(3), 260-268. [More Information]

2003

  • Sze, D., Brown, R., Yuen, E., Gibson, J., Ho, P., Raitakari, M., Basten, A., Joshua, D., Fazekas de St Groth, B. (2003). Clonal Cytotoxic T Cells in Myeloma. Leukemia and Lymphoma, 44(10), 1667-1674. [More Information]
  • Sze, D., Brown, R., Yang, S., Gibson, J., Ho, P., Fazekas de St Groth, B., Basten, A., Joshua, D. (2003). Prediction of high affinity class I-restricted multiple myeloma idiotype peptide epitopes. Leukemia and Lymphoma, 44(9), 1557-1568. [More Information]

2002

  • Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas de St Groth, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264. [More Information]
  • Fazekas de St Groth, B., Smith, A., Bosco, J., Sze, D., Power, C., Austen, F. (2002). Experimental models linking dendritic cell lineage, phenotype and function. Immunology and Cell Biology, 80(5), 469-476. [More Information]

2001

  • Bertolino, P., Bowen, D., McCaughan, G., Fazekas de St Groth, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.
  • Sze, D., Giesajtis,, G., Brown, R., Raitakari, M., Gibson, J., Ho, P., Baxter, A., Fazekas de St Groth, B., Basten, A., Joshua, D. (2001). Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8+Cd57+CD28- compartment. Blood, 98(9), 2817-2827.

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