Associate Professor Barry Slobedman

Associate Professor
Medicine (Immunology & Infectious Diseases), Central Clinical School

Telephone 9351 4334
Fax 9351 5319

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Biographical details

Associate Professor Barry Slobedman obtained both a BSc (with Honours) and a PhD in molecular virology from the University of Adelaide before moving to Stanford University (USA) where he trained as a post-doctoral research fellow at the Stanford University Medical Center in the Department of Microbiology and Immunology. He returned to Australia as a Rolf Edgar Lake Fellow and established an independent research group in 2000.

A/Prof Slobedman has held continuous competitive NHMRC Project and/or Program grant funding throughout his career. He is currently an Editorial Board member of the Journal of General Virology and Herpesviridae, and is past Treasurer of the Australasian Virology Society.

Research interests

Associate Professor Barry Slobedman is head of the Cytomegalovirus (CMV) Research Group. Human CMV is a herpesvirus which infects a vast majority of the world¿s population, where it is a leading cause of opportunistic and congenital disease. Primary productive infection leads to a lifelong latent infection that is characterised by maintenance of the viral genome without infectious virus production. Periodically, the virus reactivates from latency and is shed in bodily secretions. Whilst primary and reactivated infections are usually mild or asymptomatic in healthy adults, primary infection is a major cause of serious congenital infection leading to still birth or neurological damage in children and reactivated infection is a major cause of life-threatening disease in immunosuppressed individuals, such as those with HIV AIDS and in allogeneic stem cell and solid organ transplant recipients.

The overall goal of the CMV Research Group is to define the mechanisms by which CMV causes life-threatening disease in these at-risk individuals, so as to provide a rational basis for the design of novel anti-viral therapeutics to prevent or treat CMV disease. The CMV Research Group consists of Postdocs as well as PhD and Honours students and positions are frequently available for those with a keen interest in biomedical research.

Selected grants

2015

  • Mechanisms by which varicella zoster virus and herpes simplex virus control host functions to enhance pathogenesis; Abendroth A, Slobedman B, McSharry B; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • How does human cytomegalovirus control host responses to infection to facilitate human disease; Slobedman B, Mocarski E, Abendroth A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Defining key mechanisms that underpin neuropathogenesis of varicella zoster virus during herpes zoster; Abendroth A, Arvin A, Slobedman B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • Defining a virally-encoded molecular switch between productive and latent phases of human cytomegalovirus infection.; Slobedman B, Miller W, Mocarski E, Mocarski E; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Immunopathogenesis of Varicella zoster virus infection; Abendroth A, Arvin A, Slobedman B; DVC Research/Bridging Support Grant.
  • A pathway connecting infection, Atherosclerosis and metabolic disorders; Slobedman B, Sviridov D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • The role of varicella zoster virus in modulating cutaneous infection; Abendroth A, Arvin A, Slobedman B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Human cytomegalovirus encoded control of the latent phase of infection; Slobedman B, Mocarski E, Abendroth A; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Viral and host cell gene expression and functions during the establishment and maintenance phases of human cytomegalovirus latent infection; Slobedman B; DVC Research/Bridging Support Grant.

2009

  • Human cytomegalovirus gene expression and functions during latent infection & reactivation; Slobedman B, Mocarski E; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Functions encoded by latent human cytomegalovirus genes; Slobedman B; University of Sydney/Research & Development.

2005

  • Immunopathogenesis of varicella zoster virus infection; Abendroth A, Slobedman B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Pathogenesis of persistant human virus infections of global significance - USYD contribution to supporting 2005 NHMRC program Grant 358399; Cunningham A, Brew B, Crowe S, Lewin S, Slobedman B, Wesselingh S; University of Sydney/Internal Research Grant Allocations - Faculty of Medicine.

2004

  • Interactions between HIV and mycobacterial infections of macrophages mediated by changes in gene expression; Cunningham A, Britton W, Slobedman B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms of immune modulation by human cytomegalovirus during the latent phase of infection; Slobedman B, Abendroth A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Viral and host cell gene expression during the establishment and maintenance phases of human cytomegalovirus latency; Slobedman B, Cunningham A; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Molecular mechanisms of varicella zoster virus interactions with key target cells; Abendroth A, Cunningham A, Slobedman B; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Analysis of viral and cellular gene expression during human cytomegalovirus latent infection of hematopoietic cells; Slobedman B, Cunningham A; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Steain, M., Slobedman, B., Abendroth, A. (2010). Experimental Models to Study Varicella-Zoster Virus Infection of Neurons. In A Abendroth, A M Marvin and J F Moffat (Eds.), Current Topics in Microbiology and Immunology: Varicella-zoster Virus, (pp. 211-228). Germany: Springer-Verlag.
  • Abendroth, A., Kinchington, P., Slobedman, B. (2010). Varicella Zoster Virus Immune Evasion Strategies. In A Abendroth, A M Marvin and J F Moffat (Eds.), Current Topics in Microbiology and Immunology: Varicella-zoster Virus, (pp. 155-171). Germany: Springer-Verlag.

Journals

  • Steain, M., Sutherland, J., Rodriguez, M., Cunningham, A., Slobedman, B., Abendroth, A. (2014). Analysis of T Cell Responses during Active Varicella-Zoster Virus Reactivation in Human Ganglia. Journal of Virology, 88(5), 2704-2716. [More Information]
  • Sunarto, A., McColl, K., Crane, M., Schat, K., Slobedman, B., Barnes, A., Walker, P. (2014). Characteristics of cyprinid herpesvirus 3 in different phases of infection: Implications for disease transmission and control. Virus Research, 188, 45-53. [More Information]
  • McSharry, B., Forbes, S., Cao, J., Avdic, S., Machala, E., Gottlieb, D., Abendroth, A., Slobedman, B. (2014). Human cytomegalovirus upregulates expression of the lectin, galectin-9, via induction of beta interferon. Journal of Virology, 88(18), 10990-10994. [More Information]
  • Avdic, S., McSharry, B., Slobedman, B. (2014). Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus. Frontiers in Microbiology, 5, 337. [More Information]
  • Avdic, S., Cao, J., McSharry, B., Clancy, L., Brown, R., Steain, M., Gottlieb, D., Abendroth, A., Slobedman, B. (2013). Human Cytomegalovirus Interleukin-10 Polarizes Monocytes toward a Deactivated M2c Phenotype To Repress Host Immune Responses. Journal of Virology, 87(18), 10273-10282. [More Information]
  • Christensen, J., Steain, M., Slobedman, B., Abendroth, A. (2013). Varicella-zoster virus glycoprotein I is essential for spread in dorsal root ganglia and facilitates axonal localization of structural virion components in neuronal cultures. Journal of Virology, 87(24), 13719-13728. [More Information]
  • McSharry, B., Avdic, S., Slobedman, B. (2012). Human Cytomegalovirus Encoded Homologs of Cytokines, Chemokines and their Receptors: Roles in Immunomodulation. Viruses, 4(11), 2448-2470. [More Information]
  • Bowles, J., Steain, M., Slobedman, B., Abendroth, A. (2012). Inhibition of integrin a6 expression by cell-free varicella zoster virus. Journal of General Virology, 93(8), 1725-1730. [More Information]
  • Sunarto, A., Liongue, C., McColl, K., Adams, M., Bulach, D., Crane, M., Schat, K., Slobedman, B., Barnes, A., Ward, A., et al (2012). Koi Herpesvirus Encodes and Expresses a Functional Interleukin-10. Journal of Virology, 86(21), 11512-11520. [More Information]
  • Slobedman, B., Mocarski, E. (2012). Mechanisms modulating immune clearance during human cytomegalovirus latency. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 109(36), 14291-14292. [More Information]
  • Steain, M., Slobedman, B., Abendroth, A. (2012). The host immune response to varicella zoster virus. Future Virology, 7(12), 1205-1220. [More Information]
  • Sloan, E., Henriquez, R., Kinchington, P., Slobedman, B., Abendroth, A. (2012). Varicella-Zoster Virus Inhibition of the NF-kB Pathway during Infection of Human Dendritic Cells: Role for Open Reading Frame 61 as a Modulator of NF-kB Activity. Journal of Virology, 86(2), 1193-1202. [More Information]
  • Christensen, J., Steain, M., Slobedman, B., Abendroth, A. (2011). Differentiated neuroblastoma cells provide a highly efficient model for studies of productive varicella-zoster virus infection of neuronal cells. Journal of Virology, 85(16), 8436-8442. [More Information]
  • Tan, J., Avdic, S., Cao, J., Mocarski, E., White, K., Abendroth, A., Slobedman, B. (2011). Inhibition of 2' ,5' -Oligoadenylate Synthetase Expression and Function by the Human Cytomegalovirus ORF94 Gene Product. Journal of Virology, 85(11), 5696-5700. [More Information]
  • Steain, M., Gowrishankar, K., Rodriguez, M., Slobedman, B., Abendroth, A. (2011). Upregulation of CXCL10 in Human Dorsal Root Ganglia during Experimental and Natural Varicella-Zoster Virus Infection. Journal of Virology, 85(1), 626-631. [More Information]
  • Avdic, S., Cao, J., Cheung, A., Abendroth, A., Slobedman, B. (2011). Viral Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection Modulates Latently Infected Myeloid Cell Differentiation. Journal of Virology, 85(14), 7465-7471. [More Information]
  • Gowrishankar, K., Steain, M., Cunningham, A., Rodriguez, M., Blumbergs, P., Slobedman, B., Abendroth, A. (2010). Characterization of the host immune response in human Ganglia after herpes zoster. Journal of Virology, 84(17), 8861-8870. [More Information]
  • Gibson, J., Slobedman, B., Harikrishnan, K., Williamson, S., Minchenko, D., El-Osta, A., Stern, J., Christodoulou, J. (2010). Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain. BMC Neuroscience, 11(53), 53-1-53-16. [More Information]
  • Slobedman, B., Cao, J., Webster, B., McAllery, S., Cheung, A., Tan, J., Abendroth, A. (2010). Human cytomegalovirus latent infection and associated viral gene expression. Future Microbiology, 5(6), 883-900. [More Information]
  • Huch, J., Cunningham, A., Arvin, A., Nasr, N., Santegoets, S., Slobedman, E., Slobedman, B., Abendroth, A. (2010). Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection. Journal of Virology, 84(8), 4060-4072. [More Information]
  • Jarowowski, A., Cheng, W., Westhorpe, C., Abendroth, A., Crowe, S., Slobedman, B. (2009). Enhanced monocyte Fc phagocytosis by a homologue of interleukin-10 encoded by human cytomegalovirus. Virology, 391(1), 20-24. [More Information]
  • Maddocks, S., Scandurra, G., Nourse, C., Bye, C., Williams, R., Slobedman, B., Cunningham, A., Britton, W. (2009). Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosis. Tuberculosis, 89(4), 285-293. [More Information]
  • Harman, A., Kraus, M., Bye, C., Byth Wilson, K., Turville, S., Tang, O., Mercier, S., Nasr, N., Stern, J., Slobedman, B., Cunningham, A., et al (2009). HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood, 114(1), 85-94. [More Information]
  • Cheung, A., Gottlieb, D., Plachter, B., Pepperl-Klindworth, S., Avdic, S., Cunningham, A., Abendroth, A., Slobedman, B. (2009). The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency. Blood, 114(19), 4128-4137. [More Information]
  • Slobedman, B., Barry, P., Spencer, J., Abendroth, A. (2009). Virus encoded homologs of cellular interleukin-10 and their control of host immune function. Journal of Virology, 83(19), 9618-29. [More Information]
  • Jenkins, C., Garcia, W., Abendroth, A., Slobedman, B. (2008). Expression of a human cytomegalovirus latency-associated homolog of interleukin-10 during the productive phase of infection. Virology, 370(2), 285-294. [More Information]
  • Stern, J., Slobedman, B. (2008). Human cytomegalovirus latent infection of myeloid cells directs monocyte migration by up-regulating monocyte chemotactic protein-1. Journal of Immunology, 180(10), 6577-6585. [More Information]
  • Jenkins, C., Garcia, W., Godwin, M., Spencer, J., Stern, J., Abendroth, A., Slobedman, B. (2008). Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection. Journal of Virology, 82(7), 3736-3750. [More Information]
  • Slobedman, B., Cheung, A. (2008). Microarrays for the study of viral gene expression during human cytomegalovirus latent infection. Methods in molecular medicine, 141, 153-175. [More Information]
  • Stern, J., Cao, J., Xu, J., Mocarski, E., Slobedman, B. (2008). Repression of human cytomegalovirus major immediate early gene expression by the cellular transcription factor CCAAT displacement protein. Virology, 378(2), 214-225. [More Information]
  • Spencer, J., Cadaoas, J., Castillo, P., Saini, V., Slobedman, B. (2008). Stimulation of B lymphocytes by cmvIL-10 but not LAcmvIL-10. Virology, 374(1), 164-169. [More Information]
  • Gowrishankar, K., Slobedman, B., Cunningham, A., Miranda Saksena, M., Boadle, R., Abendroth, A. (2007). Productive varicella-zoster virus infection of cultured intact human ganglia. Journal of Virology, 81(12), 6752-6756. [More Information]
  • Scandurra, G., Williams, R., Triccas, J., Pinto (Pinto-Nadanachandran), R., Gicquel, B., Slobedman, B., Cunningham, A., Britton, W. (2006). Effect of phthiocerol dimycocerosate deficiency on the transcriptional response of human macrophages to Mycobacterium tuberculosis. Microbes and Infection, 9(1), 87-95. [More Information]
  • Slobedman, B. (2006). In situ PCR for the detection of human cytomegalovirus in suspension cells during the latent phase of infection. Methods in Molecular Biology, 334, 199-209. [More Information]
  • Hood, C., Cunningham, A., Slobedman, B., Arvin, A., Sommer, M., Kinchington, P., Abendroth, A. (2006). Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons. Journal of Virology, 80(2), 1025-1031. [More Information]
  • Cheung, A., Abendroth, A., Cunningham, A., Slobedman, B. (2006). Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells. Blood, 108(12), 3691-3699. [More Information]
  • Jenkins, C., Abendroth, A., Slobedman, B. (2004). A Novel Viral Transcript With Homology To Human Interleukin-10 Is Expressed During Latent Human Cytomegalovirus Infection. Journal of Virology, 78(3), 1440-1447.
  • Slobedman, B., Stern, J., Cunningham, A., Abendroth, A., Abate, D., Mocarski, E. (2004). Impact Of Human Cytomegalovirus Latent Infection On Myeloid Progenitor Cell Gene Expression. Journal of Virology, 78(8), 4054-62.
  • Morrow, G., Slobedman, B., Cunningham, A., Abendroth, A. (2003). Varicella-zoster virus productively infects mature dendritic cells and alters their immune function. Journal of Virology, 77(8), 4950-4959.
  • Hood, C., Cunningham, A., Slobedman, B., Boadle, R., Abendroth, A. (2003). Varicella-zoster virus-infected human sensory neurons are resistant to apoptosis, yet human foreskin fibroblasts are susceptible: evidence for a cell-type-specific apoptotic response. Journal of Virology, 77(23), 12852-12864.
  • Slobedman, B., Mocarski, E., Arvin, A., Mellins, E., Abendroth, A. (2002). Latent cytomegalovirus down-regulates major histocompatibility complex class II expression on myeloid progenitors. Blood, 100(8), 2867-2873.
  • Abendroth, A., Morrow, G., Cunningham, A., Slobedman, B. (2001). Varicella-zoster virus infection of human dendritic cells and transmission to T cells: implications for virus dissemination in the host. Journal of Virology, 75, 6183-6192.

Patents

  • Slobedman, B., Abendroth, A., Jenkins, C. (2012). Interleukin-10 Homologue and Uses Thereof. Patent No. 8133700.
  • Jenkins, C., Abendroth, A., Slobedman, B. (2010). Latent Phase Viral Interleukin-10-(Vii-10) and Uses Thereof. Patent No. 1702068, 2004293499, 602004025509.2. Germany. [More Information]

2014

  • Steain, M., Sutherland, J., Rodriguez, M., Cunningham, A., Slobedman, B., Abendroth, A. (2014). Analysis of T Cell Responses during Active Varicella-Zoster Virus Reactivation in Human Ganglia. Journal of Virology, 88(5), 2704-2716. [More Information]
  • Sunarto, A., McColl, K., Crane, M., Schat, K., Slobedman, B., Barnes, A., Walker, P. (2014). Characteristics of cyprinid herpesvirus 3 in different phases of infection: Implications for disease transmission and control. Virus Research, 188, 45-53. [More Information]
  • McSharry, B., Forbes, S., Cao, J., Avdic, S., Machala, E., Gottlieb, D., Abendroth, A., Slobedman, B. (2014). Human cytomegalovirus upregulates expression of the lectin, galectin-9, via induction of beta interferon. Journal of Virology, 88(18), 10990-10994. [More Information]
  • Avdic, S., McSharry, B., Slobedman, B. (2014). Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus. Frontiers in Microbiology, 5, 337. [More Information]

2013

  • Avdic, S., Cao, J., McSharry, B., Clancy, L., Brown, R., Steain, M., Gottlieb, D., Abendroth, A., Slobedman, B. (2013). Human Cytomegalovirus Interleukin-10 Polarizes Monocytes toward a Deactivated M2c Phenotype To Repress Host Immune Responses. Journal of Virology, 87(18), 10273-10282. [More Information]
  • Christensen, J., Steain, M., Slobedman, B., Abendroth, A. (2013). Varicella-zoster virus glycoprotein I is essential for spread in dorsal root ganglia and facilitates axonal localization of structural virion components in neuronal cultures. Journal of Virology, 87(24), 13719-13728. [More Information]

2012

  • McSharry, B., Avdic, S., Slobedman, B. (2012). Human Cytomegalovirus Encoded Homologs of Cytokines, Chemokines and their Receptors: Roles in Immunomodulation. Viruses, 4(11), 2448-2470. [More Information]
  • Bowles, J., Steain, M., Slobedman, B., Abendroth, A. (2012). Inhibition of integrin a6 expression by cell-free varicella zoster virus. Journal of General Virology, 93(8), 1725-1730. [More Information]
  • Sunarto, A., Liongue, C., McColl, K., Adams, M., Bulach, D., Crane, M., Schat, K., Slobedman, B., Barnes, A., Ward, A., et al (2012). Koi Herpesvirus Encodes and Expresses a Functional Interleukin-10. Journal of Virology, 86(21), 11512-11520. [More Information]
  • Slobedman, B., Abendroth, A., Jenkins, C. (2012). Interleukin-10 Homologue and Uses Thereof. Patent No. 8133700.
  • Slobedman, B., Mocarski, E. (2012). Mechanisms modulating immune clearance during human cytomegalovirus latency. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 109(36), 14291-14292. [More Information]
  • Steain, M., Slobedman, B., Abendroth, A. (2012). The host immune response to varicella zoster virus. Future Virology, 7(12), 1205-1220. [More Information]
  • Sloan, E., Henriquez, R., Kinchington, P., Slobedman, B., Abendroth, A. (2012). Varicella-Zoster Virus Inhibition of the NF-kB Pathway during Infection of Human Dendritic Cells: Role for Open Reading Frame 61 as a Modulator of NF-kB Activity. Journal of Virology, 86(2), 1193-1202. [More Information]

2011

  • Christensen, J., Steain, M., Slobedman, B., Abendroth, A. (2011). Differentiated neuroblastoma cells provide a highly efficient model for studies of productive varicella-zoster virus infection of neuronal cells. Journal of Virology, 85(16), 8436-8442. [More Information]
  • Tan, J., Avdic, S., Cao, J., Mocarski, E., White, K., Abendroth, A., Slobedman, B. (2011). Inhibition of 2' ,5' -Oligoadenylate Synthetase Expression and Function by the Human Cytomegalovirus ORF94 Gene Product. Journal of Virology, 85(11), 5696-5700. [More Information]
  • Steain, M., Gowrishankar, K., Rodriguez, M., Slobedman, B., Abendroth, A. (2011). Upregulation of CXCL10 in Human Dorsal Root Ganglia during Experimental and Natural Varicella-Zoster Virus Infection. Journal of Virology, 85(1), 626-631. [More Information]
  • Avdic, S., Cao, J., Cheung, A., Abendroth, A., Slobedman, B. (2011). Viral Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection Modulates Latently Infected Myeloid Cell Differentiation. Journal of Virology, 85(14), 7465-7471. [More Information]

2010

  • Gowrishankar, K., Steain, M., Cunningham, A., Rodriguez, M., Blumbergs, P., Slobedman, B., Abendroth, A. (2010). Characterization of the host immune response in human Ganglia after herpes zoster. Journal of Virology, 84(17), 8861-8870. [More Information]
  • Gibson, J., Slobedman, B., Harikrishnan, K., Williamson, S., Minchenko, D., El-Osta, A., Stern, J., Christodoulou, J. (2010). Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain. BMC Neuroscience, 11(53), 53-1-53-16. [More Information]
  • Steain, M., Slobedman, B., Abendroth, A. (2010). Experimental Models to Study Varicella-Zoster Virus Infection of Neurons. In A Abendroth, A M Marvin and J F Moffat (Eds.), Current Topics in Microbiology and Immunology: Varicella-zoster Virus, (pp. 211-228). Germany: Springer-Verlag.
  • Slobedman, B., Cao, J., Webster, B., McAllery, S., Cheung, A., Tan, J., Abendroth, A. (2010). Human cytomegalovirus latent infection and associated viral gene expression. Future Microbiology, 5(6), 883-900. [More Information]
  • Huch, J., Cunningham, A., Arvin, A., Nasr, N., Santegoets, S., Slobedman, E., Slobedman, B., Abendroth, A. (2010). Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection. Journal of Virology, 84(8), 4060-4072. [More Information]
  • Jenkins, C., Abendroth, A., Slobedman, B. (2010). Latent Phase Viral Interleukin-10-(Vii-10) and Uses Thereof. Patent No. 1702068, 2004293499, 602004025509.2. Germany. [More Information]
  • Abendroth, A., Kinchington, P., Slobedman, B. (2010). Varicella Zoster Virus Immune Evasion Strategies. In A Abendroth, A M Marvin and J F Moffat (Eds.), Current Topics in Microbiology and Immunology: Varicella-zoster Virus, (pp. 155-171). Germany: Springer-Verlag.

2009

  • Jarowowski, A., Cheng, W., Westhorpe, C., Abendroth, A., Crowe, S., Slobedman, B. (2009). Enhanced monocyte Fc phagocytosis by a homologue of interleukin-10 encoded by human cytomegalovirus. Virology, 391(1), 20-24. [More Information]
  • Maddocks, S., Scandurra, G., Nourse, C., Bye, C., Williams, R., Slobedman, B., Cunningham, A., Britton, W. (2009). Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosis. Tuberculosis, 89(4), 285-293. [More Information]
  • Harman, A., Kraus, M., Bye, C., Byth Wilson, K., Turville, S., Tang, O., Mercier, S., Nasr, N., Stern, J., Slobedman, B., Cunningham, A., et al (2009). HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood, 114(1), 85-94. [More Information]
  • Cheung, A., Gottlieb, D., Plachter, B., Pepperl-Klindworth, S., Avdic, S., Cunningham, A., Abendroth, A., Slobedman, B. (2009). The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency. Blood, 114(19), 4128-4137. [More Information]
  • Slobedman, B., Barry, P., Spencer, J., Abendroth, A. (2009). Virus encoded homologs of cellular interleukin-10 and their control of host immune function. Journal of Virology, 83(19), 9618-29. [More Information]

2008

  • Jenkins, C., Garcia, W., Abendroth, A., Slobedman, B. (2008). Expression of a human cytomegalovirus latency-associated homolog of interleukin-10 during the productive phase of infection. Virology, 370(2), 285-294. [More Information]
  • Stern, J., Slobedman, B. (2008). Human cytomegalovirus latent infection of myeloid cells directs monocyte migration by up-regulating monocyte chemotactic protein-1. Journal of Immunology, 180(10), 6577-6585. [More Information]
  • Jenkins, C., Garcia, W., Godwin, M., Spencer, J., Stern, J., Abendroth, A., Slobedman, B. (2008). Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection. Journal of Virology, 82(7), 3736-3750. [More Information]
  • Slobedman, B., Cheung, A. (2008). Microarrays for the study of viral gene expression during human cytomegalovirus latent infection. Methods in molecular medicine, 141, 153-175. [More Information]
  • Stern, J., Cao, J., Xu, J., Mocarski, E., Slobedman, B. (2008). Repression of human cytomegalovirus major immediate early gene expression by the cellular transcription factor CCAAT displacement protein. Virology, 378(2), 214-225. [More Information]
  • Spencer, J., Cadaoas, J., Castillo, P., Saini, V., Slobedman, B. (2008). Stimulation of B lymphocytes by cmvIL-10 but not LAcmvIL-10. Virology, 374(1), 164-169. [More Information]

2007

  • Gowrishankar, K., Slobedman, B., Cunningham, A., Miranda Saksena, M., Boadle, R., Abendroth, A. (2007). Productive varicella-zoster virus infection of cultured intact human ganglia. Journal of Virology, 81(12), 6752-6756. [More Information]

2006

  • Scandurra, G., Williams, R., Triccas, J., Pinto (Pinto-Nadanachandran), R., Gicquel, B., Slobedman, B., Cunningham, A., Britton, W. (2006). Effect of phthiocerol dimycocerosate deficiency on the transcriptional response of human macrophages to Mycobacterium tuberculosis. Microbes and Infection, 9(1), 87-95. [More Information]
  • Slobedman, B. (2006). In situ PCR for the detection of human cytomegalovirus in suspension cells during the latent phase of infection. Methods in Molecular Biology, 334, 199-209. [More Information]
  • Hood, C., Cunningham, A., Slobedman, B., Arvin, A., Sommer, M., Kinchington, P., Abendroth, A. (2006). Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons. Journal of Virology, 80(2), 1025-1031. [More Information]
  • Cheung, A., Abendroth, A., Cunningham, A., Slobedman, B. (2006). Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells. Blood, 108(12), 3691-3699. [More Information]

2004

  • Jenkins, C., Abendroth, A., Slobedman, B. (2004). A Novel Viral Transcript With Homology To Human Interleukin-10 Is Expressed During Latent Human Cytomegalovirus Infection. Journal of Virology, 78(3), 1440-1447.
  • Slobedman, B., Stern, J., Cunningham, A., Abendroth, A., Abate, D., Mocarski, E. (2004). Impact Of Human Cytomegalovirus Latent Infection On Myeloid Progenitor Cell Gene Expression. Journal of Virology, 78(8), 4054-62.

2003

  • Morrow, G., Slobedman, B., Cunningham, A., Abendroth, A. (2003). Varicella-zoster virus productively infects mature dendritic cells and alters their immune function. Journal of Virology, 77(8), 4950-4959.
  • Hood, C., Cunningham, A., Slobedman, B., Boadle, R., Abendroth, A. (2003). Varicella-zoster virus-infected human sensory neurons are resistant to apoptosis, yet human foreskin fibroblasts are susceptible: evidence for a cell-type-specific apoptotic response. Journal of Virology, 77(23), 12852-12864.

2002

  • Slobedman, B., Mocarski, E., Arvin, A., Mellins, E., Abendroth, A. (2002). Latent cytomegalovirus down-regulates major histocompatibility complex class II expression on myeloid progenitors. Blood, 100(8), 2867-2873.

2001

  • Abendroth, A., Morrow, G., Cunningham, A., Slobedman, B. (2001). Varicella-zoster virus infection of human dendritic cells and transmission to T cells: implications for virus dissemination in the host. Journal of Virology, 75, 6183-6192.

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