Associate Professor Barry Slobedman

Associate Professor
Medicine (Immunology & Infectious Diseases), Central Clinical School
Westmead Millennium Institute for Medical Research

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T: 9351 4334
F: 9351 5319
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Biographical details

Research interests

Associate Professor Barry Slobedman is head of the Cytomegalovirus (CMV) Research Group. Human CMV is a herpesvirus which infects a vast majority of the world¿s population, where it is a leading cause of opportunistic and congenital disease. Primary productive infection leads to a lifelong latent infection that is characterised by maintenance of the viral genome without infectious virus production. Periodically, the virus reactivates from latency and is shed in bodily secretions. Whilst primary and reactivated infections are usually mild or asymptomatic in healthy adults, primary infection is a major cause of serious congenital infection leading to still birth or neurological damage in children and reactivated infection is a major cause of life-threatening disease in immunosuppressed individuals, such as those with HIV AIDS and in allogeneic stem cell and solid organ transplant recipients.

The overall goal of the CMV Research Group is to define the mechanisms by which CMV causes life-threatening disease in these at-risk individuals, so as to provide a rational basis for the design of novel anti-viral therapeutics to prevent or treat CMV disease. The CMV Research Group consists of Postdocs as well as PhD and Honours students and positions are frequently available for those with a keen interest in biomedical research.

Current national competitive grants*

2012

Defining a virally-encoded molecular switch between productive and latent phases of human cytomegalovirus infection.
Slobedman B, Miller W, Mocarski E
NHMRC Project Grants ($326,175 over 3 years)

* Grants administered through the University of Sydney