Dr Belal Chami

Lecturer
Cellular and Molecular Pathology Research Unit, Oral Pathology

Member of the Charles Perkins Centre

Telephone 02 8890 7401

Map

Biographical details

Dr Belal Chami completed his PhD in 2014 in the area of of immunobiology and Inflammatory Bowel Disease. He later took a postdoctal position in the Discipline of Pathology with Professor Paul Witting, where he published in several fields including neurodegeneration, endothelial dysfunction and colitis.

In 2018, Dr Chami was promoted to Lecturer in the Discipline of Oral Pathology at The University of Sydney, Westmead and has been appointed in Professor Hans Zoellner's.

Research interests

Dr Belal Chami is interested in investigating cell to cell interactions of cancer and noncancer cells, chiefly the intercellular transfer of cellular material and subsequent phenotypic and epigenetic changes in cancer cells.

Dr Belal Chami is also interested in exploring the relationship between oxidative stress/damage in the evolution of tissue damage in acute and chronic inflammatory conditions, namely Inflammatory Bowel Disease (IBD). More specifically, Dr Belal Chami is interested in using cyclic nitroxides that have previously been shown to effectively inhibit myeloperoxidase (MPO)-induced ROSin vitro. MPO produces hypochlorous acid (HOCl) - a powerful 2-electron oxidant known to cause tissue damage in many human diseases, including IBD, rheumatoid arthritis and acute myocardial infarctions. Therefore cyclic nitroxides may provide protection from ROS-mediated tissue insult during inflammation. In addition to this, he is also interested in examining the relationship between oxidative stress and neurodegeneration in collaborative projects with Dr Greg Sutherland in neuropathology. Dr Belal Chami has recently shown interest in vascular biology, specifically, examining the effects of Serum Amyloid A in developing endothelial dysfunction - a precursor to atherosclerosis.

Teaching and supervision

Dr Belal Cham It is highly committed and passionate about teaching within the university and has demonstrated this by active engagement in lecturing, tutoring and supervision both the undergraduate and HDR arena. Since 2018, Dr Chami has been the primary supervisor to 5x honours student, 1x PhD student, 5x Summer Research Scholarship students, 1x Talented Student Program, 1x DMD2 student, 1x International Internship (University of Connecticut) and 1x High School Internships (Sydney Girls). He has also co-supervise 2x honours students and 1x PhD student. Furthermore, all his honours students have completed with H1 outcomes and many have been the recipient of Young Investigator Awards at various conferences. In 2016 he completed the Graduate Certificate in Education (Higher Education) – A program designed to support teaching staff in developing their professional expertise as university teachers to better understand and enhance the learning of their student. In the same year, he designed new pedagogical approaches for CPATH3202 museum tutorials, whereby students mediated their learning in a peer-to-peer fashion. He also designed a new teaching approach to the microscopy tutorial sessions and developed workbooks for students enrolled in The Pathogenesis of Human Diseases (CPAT3201) that encouraged structural scaffolding as a learning approach.

In 2017, Dr Chami obtained a DVC educational innovation grant ($24,620) as a project leader to create digital resources (a series of Ainsworth’s video bytes -SAVb) for undergraduate and postgraduate students within the discipline of pathology. In addition to his lecturing roles, Dr Chami headed PBL sessions in the pathology museum for 3rd year students enrolled in CPAT3202 from 2013-14. He tutored undergraduate Pathogenesis Research Projects (PRP) from 2010-2016. In 2016, Dr Chami tutored PBL groups for medicine foundation blocks 1 and 2 forthe faculty of medicine.

Dr Chami currently teaches in the BOH and AMED program.

Current research students

Project title Research student
Efficacy of cyclic nitroxides in the amelioration of experimental colitis and colorectal cancer Patrick SAN GABRIEL

Current projects

  • Does intercellular transfer enhance cancer cell proliferation, migration and survival?
  • Does the inhibition of MPO attenuate experimental colitis-induced tissue damage in vivo? Canin vivo MPO inhibition via cyclic nitroxides ameliorate inflammation and subsequent host-tissue damage?

Awards and honours

Inspire Australia Research Competition: https://www.thinkable.org/submission_entries/dJePnvkz

Young Research Award from the Society of Free Radical Research

Medical Advances Without Animals (MAWA) grant

ECR International Travel Scholarship

In the media

http://sydney.edu.au/news/staff/2576.html?newsstoryid=15362

https://wordvine.sydney.edu.au/files/2142/13398/#igw209-a-features-

Selected grants

2017

  • Promoting a holistic understanding of pathology - An approach using media resources; Chami B, Witting P, Hambly B, Kekic M; DVC Education/Large Educational Innovation Grant.

2016

  • Assessing protein level and distribution in Alzheimer’s disease-affected human brains using matrix assisted laser desorption / ionization (MALDI) imaging mass spectrometry: A methodology to image proteins in tissue without animal-derived antibodies; Witting P, Chami B, Sutherland G, Wang X, Youssef P; Medical Advances Without Animals (MAWA)/Research Grant.
  • SMS ECR Overseas Conference Support 2016; Chami B; Sydney Medical School/Early Career Researcher Overseas Travel Grant.

Selected publications

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Book Chapters

  • Chami, B., Bao, B. (2012). Salmonella: Invasion, Evasion & Persistence. In Bassam A Annous and Joshua B Gurtler (Eds.), Salmonella - Distribution, Adaptation, Control Measures and Molecular Technologies, (pp. 313-338). Rijeka: InTech Publishers. [More Information]

Journals

  • Alghamdi, O., King, N., Andronicos, N., Jones, G., Chami, B., Witting, P., Moens, P. (2019). Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing. Molecular and Cellular Biochemistry, 452, 71-82. [More Information]
  • Vallejo, A., Chami, B., Dennis, J., Simone, M., Ahmad, G., Abdo, A., Sharma, A., Shihata, W., Martin, N., Chin-Dusting, J., Witting, P., et al (2019). NFkB Inhibition Mitigates Serum Amyloid A-Induced Pro-Atherogenic Responses in Endothelial Cells and Leukocyte Adhesion and Adverse Changes to Endothelium Function in Isolated Aorta. International Journal of Molecular Sciences, 20(1), 1-18. [More Information]
  • Black, H., Xu, W., Hortle, E., Britton, W., Kaur, A., New, E., Witting, P., Chami, B., Oehlers, S. (2019). The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets. Free Radical Biology and Medicine, 135, 157-166. [More Information]
  • Youssef, P., Chami, B., Lim, J., Middleton, T., Sutherland, G., Witting, P. (2018). Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease. Scientific Reports, 8(1), 11553. [More Information]
  • Chami, B., Martin, N., Dennis, J., Witting, P. (2018). Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease. Archives of Biochemistry and Biophysics, 645, 61-71. [More Information]
  • Chami, B., Yeung, A., Buckland, M., Liu, H., Fong, G., Tao, K., Bao, B. (2017). CXCR3 plays a critical role for host protection against Salmonellosis. Scientific Reports, 7(1), 1-10. [More Information]
  • Chami, B., Jeong, G., Varda, A., Maw, A., Kim, H., Fong, G., Simone, M., Rayner, B., Wang, X., Dennis, J., Witting, P. (2017). The nitroxide 4-methoxy TEMPO inhibits neutrophil-stimulated kinase activation in H9c2 cardiomyocytes. Archives of Biochemistry and Biophysics, 629, 19-35. [More Information]
  • Chami, B., Steel, A., de la Monte, S., Sutherland, G. (2016). The rise and fall of insulin signaling in Alzheimer's disease. Metabolic Brain Disease, 31(3), 497-515. [More Information]
  • Chami, B., Barrie, N., Cai, X., Wang, X., Paul, M., Morton-Chandra, R., Sharland, A., Dennis, J., Freedman, B., Witting, P. (2015). Serum amyloid a receptor blockade and incorporation into high-density lipoprotein modulates its pro-inflammatory and pro-thrombotic activities on vascular endothelial cells. International Journal of Molecular Sciences, 16(5), 11101-11124. [More Information]
  • Duong, T., Chami, B., McMahon, A., Fong, G., Dennis, J., Freedman, B., Witting, P. (2014). Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury. Journal of Neurochemistry, 130(6), 733-747. [More Information]
  • Chami, B., Yeung, A., Van Vreden, C., King, N., Bao, B. (2014). The role of CXCR3 in DSS-induced colitis. PloS One, 9(7), 1-9. [More Information]
  • Getts, D., Terry, R., Getts, M., Deffrasnes, C., Müller, M., Van Vreden, C., Ashhurst, T., Chami, B., McCarthy, D., Wu, H., Ma, J., Witting, P., Campbell, I., Reilly, D., White, M., Cordwell, S., Chadban, S., Bao, B., King, N., et al (2014). Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine, 6(219), 1-14. [More Information]
  • Sutherland, G., Chami, B., Youssef, P., Witting, P. (2013). Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? Redox Report, 18(4), 134-141. [More Information]

2019

  • Alghamdi, O., King, N., Andronicos, N., Jones, G., Chami, B., Witting, P., Moens, P. (2019). Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing. Molecular and Cellular Biochemistry, 452, 71-82. [More Information]
  • Vallejo, A., Chami, B., Dennis, J., Simone, M., Ahmad, G., Abdo, A., Sharma, A., Shihata, W., Martin, N., Chin-Dusting, J., Witting, P., et al (2019). NFkB Inhibition Mitigates Serum Amyloid A-Induced Pro-Atherogenic Responses in Endothelial Cells and Leukocyte Adhesion and Adverse Changes to Endothelium Function in Isolated Aorta. International Journal of Molecular Sciences, 20(1), 1-18. [More Information]
  • Black, H., Xu, W., Hortle, E., Britton, W., Kaur, A., New, E., Witting, P., Chami, B., Oehlers, S. (2019). The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets. Free Radical Biology and Medicine, 135, 157-166. [More Information]

2018

  • Youssef, P., Chami, B., Lim, J., Middleton, T., Sutherland, G., Witting, P. (2018). Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease. Scientific Reports, 8(1), 11553. [More Information]
  • Chami, B., Martin, N., Dennis, J., Witting, P. (2018). Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease. Archives of Biochemistry and Biophysics, 645, 61-71. [More Information]

2017

  • Chami, B., Yeung, A., Buckland, M., Liu, H., Fong, G., Tao, K., Bao, B. (2017). CXCR3 plays a critical role for host protection against Salmonellosis. Scientific Reports, 7(1), 1-10. [More Information]
  • Chami, B., Jeong, G., Varda, A., Maw, A., Kim, H., Fong, G., Simone, M., Rayner, B., Wang, X., Dennis, J., Witting, P. (2017). The nitroxide 4-methoxy TEMPO inhibits neutrophil-stimulated kinase activation in H9c2 cardiomyocytes. Archives of Biochemistry and Biophysics, 629, 19-35. [More Information]

2016

  • Chami, B., Steel, A., de la Monte, S., Sutherland, G. (2016). The rise and fall of insulin signaling in Alzheimer's disease. Metabolic Brain Disease, 31(3), 497-515. [More Information]

2015

  • Chami, B., Barrie, N., Cai, X., Wang, X., Paul, M., Morton-Chandra, R., Sharland, A., Dennis, J., Freedman, B., Witting, P. (2015). Serum amyloid a receptor blockade and incorporation into high-density lipoprotein modulates its pro-inflammatory and pro-thrombotic activities on vascular endothelial cells. International Journal of Molecular Sciences, 16(5), 11101-11124. [More Information]

2014

  • Duong, T., Chami, B., McMahon, A., Fong, G., Dennis, J., Freedman, B., Witting, P. (2014). Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury. Journal of Neurochemistry, 130(6), 733-747. [More Information]
  • Chami, B., Yeung, A., Van Vreden, C., King, N., Bao, B. (2014). The role of CXCR3 in DSS-induced colitis. PloS One, 9(7), 1-9. [More Information]
  • Getts, D., Terry, R., Getts, M., Deffrasnes, C., Müller, M., Van Vreden, C., Ashhurst, T., Chami, B., McCarthy, D., Wu, H., Ma, J., Witting, P., Campbell, I., Reilly, D., White, M., Cordwell, S., Chadban, S., Bao, B., King, N., et al (2014). Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine, 6(219), 1-14. [More Information]

2013

  • Sutherland, G., Chami, B., Youssef, P., Witting, P. (2013). Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? Redox Report, 18(4), 134-141. [More Information]

2012

  • Chami, B., Bao, B. (2012). Salmonella: Invasion, Evasion & Persistence. In Bassam A Annous and Joshua B Gurtler (Eds.), Salmonella - Distribution, Adaptation, Control Measures and Molecular Technologies, (pp. 313-338). Rijeka: InTech Publishers. [More Information]

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