Dr Ben Rayner

Senior Research Fellow
Sydney Medical School
Postdoctoral Scientist, Inflammation Research Group, Heart Research Institute

Member of the Charles Perkins Centre

Telephone (02) 8208 8900
Fax (02) 9565 5584

Map

Biographical details

Following completion of a Bachelor of Biomedical Science (Hons) degree through the University of Technology, Sydney (2002) I commenced a Research Assistant position within vascular biology, initially located at the University of NSW, then at the ANZAC Research Institute, University of Sydney (2003-2005). In 2005, I received a competitive Australian Heart Foundation Postgraduate Research Scholarship in order to undertake a PhD investigating the efficacy of a synthetic antioxidant within the setting of cardiac ischaemia reperfusion (I/R) injury using a rat open-chest model. During this period, I contributed to twelve research publications, including six as primary (first) author, was awarded the Concord Area Health Service Young Researcher of the Year Award (2004), a Society for Free Radical Research Australasia (SFRRA) Young Investigator Award (2006), a Heart Foundation Travel Award to present my research at the 7th International Congress on Coronary Artery Disease (Venice, Italy 2007) and travel funding from the Australian Synchrotron to perform research at synchrotron beamline facilities located in Taiwan and the USA.

In order to gain more technical expertise during the writing and submission of my PhD thesis I undertook a position in virology research, contributing to five journal publications in this short period (2008-2009). Following the award of my PhD, I was offered a postdoctoral scientist position working on an NHMRC funded project at the Kolling Institute of Medical Research, Royal North Shore Hospital (2010-2012). Here I developed my technical skills, learning and performing cardiac I/R balloon injury in a large animal (pig) model, as well as instructing and mentoring a PhD candidate in studies involving the rat I/R model I had become proficient in during my own PhD candidature. This research produced two publications in highly-ranked cardiovascular journals and led to me being awarded two Heart Research Australia Grants (~ $200,000).

An acute interest in redox biology and the molecular mechanisms that contribute to development of atherosclerosis and cardiovascular disease led me next to accept a postdoctoral position at the Heart Research Institute. There, my research on the effects of myeloperoxidase (MPO)-derived oxidants on cells of the vasculature resulted in numerous publications, including authoring an invited review article and a book chapter as well as receiving a Walter and Eileen Ralston Trust (Perpetual) grant ($59,000). My numerous local and international presentations during this time garnered significant attention, leading to my receiving the top-ranked Society for Free Radical Biology and Medicine (SFRBM) Young Investigator Award (2014), HRI Unity 4 Young Achiever Award for Best International Presentation ($5000; 2015), and invitations to speak at the Australian Vascular Biology Society (2015, Kiama, NSW), and the Society for Free Radical Research Australasia (2017, Tokyo, Japan) meetings. During this period I have also been primary supervisor to two PhD candidates, associate supervisor to three PhD candidates, supervisor to two Honours students and numerous international exchange and summer research project students.

My expertise in cardiac I/R injury and MPO-derived oxidants led to my being sought out by an Australian pharmaceutical company (Pharmaxis Pty Ltd) in late 2016, to evaluate the efficacy of novel small molecule inhibitors of MPO and of fibrotic processes during the detrimental remodeling of cardiac tissue following heart attack. In order to pursue this research collaboration, I received a CSIRO SIEF STEM+ Business Fellowship ($528,000 2016-2019). This ongoing industry partnership has to date yielded extensive results on the mechanisms underlying inflammatory-mediated cardiac fibrosis, the first of several publications recently appearing in the Journal of Cellular and Molecular Medicine.

Research interests

The targeting of mechanisms of fibrosis, particularly following cardiac ischaemia reperfusion injury.

Current projects

As well as being an autonomous researcher, the role of Dr. Rayner includes the laboratory instruction and supervision of postgraduate students in the fulfillment of their individual research aims leading to the award of their degrees including primary supervision of two PhD candidates, as well as a further three PhD candidates in the role of associate supervisor. Additionally, during this time Dr. Rayner has supervised numerous Summer Research projects and visiting international exchange students as well as being primary supervisor to a first class Honours candidate.

Projects:

  • Industry Partnership (Pharmaxis): Investigating the efficacy of lysyl oxidase like 2, monoamine oxidaseand MPO inhibitorsin myocardial ischemia reperfusion (I/R) injury. This project involves the use of an in vivo open-chest rat model of myocardial ischaemia and I/R injury to ascertain the protective effect of novel compounds on heart remodeling characteristics following heart attack.
  • The effect of SeMet supplementation within cardiovascular disease (CVD). This PhD project involves the use of a murine model of atherosclerosis and concurrent in vitro studies in isolated human neutrophils and macrophages to investigate the cellular mechanisms involved in extracellular trap formation and its role in lesion formation. This project follows on from another PhD thesis on the effects of SeMet supplementation within the setting of I/R injury. The current PhD candidate will be submitting her thesis in March 2019 and the work has led to interest in further research to be undertaken as part of an Endeavor Research Post-Doctoral Fellowship on the effect of SeMet supplementation within a pressure overload/hypertrophic model of CVD to be initiated in 2019.

Collaborations:

  • Professor Clare Hawkins, University of Copenhagen, Denmark.
    • Investigation into the molecular mechanisms of myeloperoxidase (MPO)-derived reactive-oxidant species-mediated damage and dysfunction within the setting of atherosclerosis.
    • The role of the unfolded protein response (UPR) in oxidative stress induced astrocyte dysfunction.
  • Associate Professor Paul Witting, University of Sydney.
    • Assessing the efficacy of the nitroxide 4-MetT on inflammation and tissue damage within in the setting of cardiac I/R injury.
    • Assessing the efficacy of therapeutic thiocyanate supplementation within the setting of inflammatory bowel disease (IBD).
  • Dr Lana McClements, University of Technology Sydney.
    • Assessing the role of FK506-binding protein like (FKBPL) in cardiac I/R injury.
  • Dr Tharani Sabaretnam, Centre for Motor Neuron Disease Research, Macquarie University / Dr Tharusha Jayasena & Ms Sonia Bustamante, Centre for Healthy Brain Ageing University of NSW.
    • Identifying analytical markers of disease within the brain.
  • Associate Professor Ravinay Bhindi, Kolling Institute of Medical Research, University of Sydney.
    • The role of the transcription factor early growth response-1 (Egr-1) in tissue damage following I/R injury.

Associations

  • Manuscript review panel member for the journals Biochemical Pharmacology, Archives of Biochemistry and Biophysics, Free Radical Research, and Redox Report.
  • Heart Foundation Collaboration & Exchange Award (CEA) Committee Member 2014-2018.
  • Member Society for Free Radical Research (SFRR) Australasia.
  • Member Society for Free Radical Biology and Medicine (SFRBM).
  • Qualified in venipuncture practice (Pathology Foundation)
  • Qualified in First Aid (St John Ambulance Aust.)

Awards and honours

  • Rayner, B.S., Wise, S., and Jarolimick, W. CSIRO/Pharmaxis funded SIEF STEM+ Business Fellowship ($528,000; 2016–2019): Investigating the efficacy of lysyl oxidase like 2, monoamine oxidase and myeloperoxidase inhibitors within myocardial ischaemia and I/R injury.
  • Rayner, B.S.and Hawkins, C.L. Walter and Eileen Ralston Trust (Perpetual) ($59,000; 2016): DNA traps - a new pathway to atherosclerosis.
  • Rayner, B.S.HRI Unity 4 Young Achiever Award for Best International Presentation ($5000; 2015)
  • Rayner, B.S. (CIA)HRI Capital Expenditure Funding ($15,374; 2014): rat surgical room equipment fit-out.
  • Awarded a Society for Free Radical Biology and Medicine(SFRBM)Young Investigator Award (November, 2014)
  • Rayner, B.S.& Bhindi, R. Heart Research Australia Grant ($148,500; 2013-2015): Investigating the molecular mechanisms of remote pre- and post-conditioning within the setting of cardiac ischemia reperfusion injury.
  • RIBG Equipment Grant – The FLOID image analyzer distributed by Life Technologies. P Witting, N King, B Hambly, B Rayner, B Freedman, L Kritharides, P Lay, M Bilek, M Davies, L Rendina, A Sharland, G Maghzal, G Sutherland, R Codd, R Payne. ($14,800; 2012)
  • Rayner, B.S.& Bhindi, R. North Shore Heart Foundation Research Grant ($48,200; 2012): Investigating the role of Egr-1 within the setting of cardiac preconditioning.
  • Recipient of an Australian Heart Foundation Travel Award to present current research at the 7th International Congress on Coronary Artery Disease, Venice, Italy (October, 2007).
  • Awarded the Society for Free Radical Research (SFRR) Young Investigator Award (December, 2006).
  • Recipient of an Australian Heart Foundation Postgraduate Research Scholarship to investigate the effects of synthetic antioxidant supplementation on myocardial ischemia reperfusion injury ($25000 p.a., 2005-2008).
  • Recipient of an Australian Heart Foundation Travel Award to present current research at the annual Society for Free Radical Research (Australasia) conference, Christchurch, New Zealand (December, 2004).
  • Awarded the Concord Area Health Service Young Researcher of the Year Award (October, 2004).

In the media

Dr Rayner’s research towards his PhD has been highlighted in an article published in the Daily Telegraph as part of National Heart Week (Friday May 6, 2005), and his recent research profile has been the focus of a Heart Research Institute “Hearts Matter” fundraising mail-out to current and potential donors (August, 2014).

Selected grants

2012

  • Egr-1 and cardiac ischemic preconditioning; Bhindi R, Rayner B; Heart Research Australia/Research Support.

Selected publications

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Journals

  • Pan, G., Rayner, B., Zhang, Y., van Reyk, D., Hawkins, C. (2018). A pivotal role for NF-kB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid. Archives of Biochemistry and Biophysics, 642, 23-30. [More Information]
  • Rayner, B., Zhang, Y., Brown, B., Reyes, L., Cogger, V., Hawkins, C. (2018). Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation. Free Radical Biology and Medicine, 129, 25-34. [More Information]
  • Manuneedhi Cholan, P., Cartland, S., Dang, L., Rayner, B., Patel, S., Thomas, S., Kavurma, M. (2018). TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro. Free Radical Biology and Medicine, 126, 341-349. [More Information]
  • Abdo, A., Rayner, B., van Reyk, D., Hawkins, C. (2017). Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction. Redox Biology, 13, 623-632. [More Information]
  • Mudaliar, H., Rayner, B., Billah, M., Kapoor, N., Lay, W., Dona, A., Bhindi, R. (2017). Remote ischemic preconditioning attenuates EGR-1 expression following myocardial ischemia reperfusion injury through activation of the JAK-STAT pathway. International Journal of Cardiology, 228, 729-741. [More Information]
  • Chami, B., Jeong, G., Varda, A., Maw, A., Kim, H., Fong, G., Simone, M., Rayner, B., Wang, X., Dennis, J., Witting, P. (2017). The nitroxide 4-methoxy TEMPO inhibits neutrophil-stimulated kinase activation in H9c2 cardiomyocytes. Archives of Biochemistry and Biophysics, 629, 19-35. [More Information]
  • Rayner, B., Love, D., Hawkins, C. (2014). Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology and Medicine, 71, 240-255. [More Information]
  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013). Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free Radical Biology and Medicine, 65, 1352-1362. [More Information]
  • Naing, Z., Rayner, B., Killikulangara, A., Vunnam, K., Leach, S., McIver, C., Scott, G., Craig, M., Lui, K., Rawlinson, W. (2013). Prevalence of viruses in stool of premature neonates at a neonatal intensive care unit. Journal of Paediatrics and Child Health, 49(3), e221-e226. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Lusk, M., Naing, Z., Rayner, B., Rismanto, N., McIver, C., Cumming, R., McGeechan, K., Rawlinson, W., Konecny, P. (2010). Trichomonas vaginalis: underdiagnosis in urban Australia could facilitate re-emergence. Sexually Transmitted Infections, 86(3), 227-230. [More Information]
  • McIver, C., Rismanto, N., Smith, C., Naing, Z., Rayner, B., Lusk, M., Konecny, P., White, P., Rawlinson, W. (2009). Multiplex PCR Testing Detection of Higher-than-Expected Rates of Cervical Mycoplasma, Ureaplasma, and Trichomonas and Viral Agent Infections in Sexually Active Australian Women. Journal of Clinical Microbiology, 47(5), 1358-1363. [More Information]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009). Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal, 423(2), 169-177. [More Information]
  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]
  • Witting, P., Rayner, B., Wu, B., Ellis, N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Witting, P., Rayner, B., Wu, B., Hamilton (Ellis), N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Hack, B., Witting, P., Rayner, B., Stocker, R., Headrick, J. (2006). Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine. Molecular and Cellular Biochemistry, 287(1-2), 165-175. [More Information]
  • Rayner, B., Hong Duong, T., Myers, S., Witting, P. (2006). Protective effect of a synthetic anti-oxidant on neuronal cell apoptosis resulting from experimental hypoxia re-oxygenation injury. Journal of Neurochemistry, 97(1), 211-221. [More Information]
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2005). Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. Journal of Biological Chemistry, 280(11), 9985-9993. [More Information]
  • Neuzil, J., Rayner, B., Lowe, H., Witting, P. (2005). Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research. Redox Report, 10(4), 187-197. [More Information]
  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372. [More Information]
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2004). Regulation Of Vascular Tone By S-Nitroso-Myoglobin. Redox Report, 9(6), 382-386. [More Information]

Conferences

  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Dillon, C., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Vogt, S., Rendina, L., Harris, H., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2006). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2005). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.

2018

  • Pan, G., Rayner, B., Zhang, Y., van Reyk, D., Hawkins, C. (2018). A pivotal role for NF-kB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid. Archives of Biochemistry and Biophysics, 642, 23-30. [More Information]
  • Rayner, B., Zhang, Y., Brown, B., Reyes, L., Cogger, V., Hawkins, C. (2018). Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation. Free Radical Biology and Medicine, 129, 25-34. [More Information]
  • Manuneedhi Cholan, P., Cartland, S., Dang, L., Rayner, B., Patel, S., Thomas, S., Kavurma, M. (2018). TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro. Free Radical Biology and Medicine, 126, 341-349. [More Information]

2017

  • Abdo, A., Rayner, B., van Reyk, D., Hawkins, C. (2017). Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction. Redox Biology, 13, 623-632. [More Information]
  • Mudaliar, H., Rayner, B., Billah, M., Kapoor, N., Lay, W., Dona, A., Bhindi, R. (2017). Remote ischemic preconditioning attenuates EGR-1 expression following myocardial ischemia reperfusion injury through activation of the JAK-STAT pathway. International Journal of Cardiology, 228, 729-741. [More Information]
  • Chami, B., Jeong, G., Varda, A., Maw, A., Kim, H., Fong, G., Simone, M., Rayner, B., Wang, X., Dennis, J., Witting, P. (2017). The nitroxide 4-methoxy TEMPO inhibits neutrophil-stimulated kinase activation in H9c2 cardiomyocytes. Archives of Biochemistry and Biophysics, 629, 19-35. [More Information]

2014

  • Rayner, B., Love, D., Hawkins, C. (2014). Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology and Medicine, 71, 240-255. [More Information]

2013

  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013). Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free Radical Biology and Medicine, 65, 1352-1362. [More Information]
  • Naing, Z., Rayner, B., Killikulangara, A., Vunnam, K., Leach, S., McIver, C., Scott, G., Craig, M., Lui, K., Rawlinson, W. (2013). Prevalence of viruses in stool of premature neonates at a neonatal intensive care unit. Journal of Paediatrics and Child Health, 49(3), e221-e226. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]

2012

  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]

2010

  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Lusk, M., Naing, Z., Rayner, B., Rismanto, N., McIver, C., Cumming, R., McGeechan, K., Rawlinson, W., Konecny, P. (2010). Trichomonas vaginalis: underdiagnosis in urban Australia could facilitate re-emergence. Sexually Transmitted Infections, 86(3), 227-230. [More Information]

2009

  • McIver, C., Rismanto, N., Smith, C., Naing, Z., Rayner, B., Lusk, M., Konecny, P., White, P., Rawlinson, W. (2009). Multiplex PCR Testing Detection of Higher-than-Expected Rates of Cervical Mycoplasma, Ureaplasma, and Trichomonas and Viral Agent Infections in Sexually Active Australian Women. Journal of Clinical Microbiology, 47(5), 1358-1363. [More Information]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009). Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal, 423(2), 169-177. [More Information]
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Dillon, C., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Vogt, S., Rendina, L., Harris, H., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.

2008

  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]

2007

  • Witting, P., Rayner, B., Wu, B., Ellis, N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Witting, P., Rayner, B., Wu, B., Hamilton (Ellis), N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]

2006

  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2006). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Hack, B., Witting, P., Rayner, B., Stocker, R., Headrick, J. (2006). Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine. Molecular and Cellular Biochemistry, 287(1-2), 165-175. [More Information]
  • Rayner, B., Hong Duong, T., Myers, S., Witting, P. (2006). Protective effect of a synthetic anti-oxidant on neuronal cell apoptosis resulting from experimental hypoxia re-oxygenation injury. Journal of Neurochemistry, 97(1), 211-221. [More Information]
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]

2005

  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2005). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2005). Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. Journal of Biological Chemistry, 280(11), 9985-9993. [More Information]
  • Neuzil, J., Rayner, B., Lowe, H., Witting, P. (2005). Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research. Redox Report, 10(4), 187-197. [More Information]

2004

  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372. [More Information]
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2004). Regulation Of Vascular Tone By S-Nitroso-Myoglobin. Redox Report, 9(6), 382-386. [More Information]

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