Dr Ben Rayner

Senior Research Fellow
Sydney Medical School
Postdoctoral Scientist, Inflammation Research Group, Heart Research Institute

Telephone (02) 8208 8900
Fax (02) 9565 5584

Curriculum vitae Curriculum vitae

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Biographical details

Career Overview: Dr Rayner is a currently a Senior Research Fellow within the Faculty of Medicine at the University of Sydney, employed as a Postdoctoral Research Officer within the Inflammation Group at the Heart Research Institute since March, 2013. His current research is broadly focused on understanding the key mechanistic elements involved in myeloperoxidase-derived oxidant mediated biological damage and how this drives lesion development in atherosclerosis. Prior to this appointment Dr Rayner was employed as a Postdoctoral Scientist through the University of Sydney within the North Shore Heart Research Group at the Kolling Institute of Medical Research where his research was focused on understanding the role of molecular transcription factors within the setting of myocardial ischaemia reperfusion (I/R) injury (heart attack). Dr Rayner has a long-held interest in cardiac and vascular research, having commenced employment following his undergraduate degree as a Research Assistant within the Centre for Vascular Research at the University of NSW and shortly thereafter within the Vascular Biology Group at the ANZAC Research Institute / University of Sydney. It was within this environment that Dr Rayner completed his PhD studies with a thesis investigating the efficacy of a synthetic antioxidant within the setting of myocardial I/R injury.

Publications: Dr Rayner has published widely and is currently listed as a contributing author on 22 research papers as well as an invited review article, all within high-ranking peer-reviewed journals with an average impact factor of 3.813. He is acknowledged as primary contributing (first) author on ~ 40% of these papers. A number of his scientific papers have been highly cited including papers published during his PhD (J. Neurochem., 97: 211-221, 2006, cited 55; Cell Physio. Biochem., 20(5): 255-68, 2007, cited 30), which has contributed to his current H-index of 9 (Web of Science).

Research Awards / Grantmanship: As a postdoctoral scientist Dr Rayner has attracted ~ $200,000 in funding, through competitive application, from Heart Research Australia (formally North Shore Heart Foundation) and is listed as a co-recipient of a RIBG Equipment grant through the University of Sydney. Dr Rayner was awarded a highly competitive National Heart Foundation (NHF) Postgraduate Research Scholarship to undertake his PhD studies and has been successful on numerous occasions in attracting travel grants in order to present his research at both the local (SFRR, Perth, 2006) and the international (SFRR, Christchurch, NZ, 2004; CCAD, Venice, Italy, 2007) level.

Selected grants

2012

  • Egr-1 and cardiac ischemic preconditioning; Bhindi R, Rayner B; North Shore Heart Research Foundation/Research Support.

Selected publications

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Journals

  • Rayner, B., Love, D., Hawkins, C. (2014). Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology and Medicine, 71, 240-255. [More Information]
  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013). Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free Radical Biology and Medicine, 65, 1352-1362. [More Information]
  • Naing, Z., Rayner, B., Killikulangara, A., Vunnam, K., Leach, S., McIver, C., Scott, G., Craig, M., Lui, K., Rawlinson, W. (2013). Prevalence of viruses in stool of premature neonates at a neonatal intensive care unit. Journal of Paediatrics and Child Health, 49(3), e221-e226. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Lusk, M., Naing, Z., Rayner, B., Rismanto, N., McIver, C., Cumming, R., McGeechan, K., Rawlinson, W., Konecny, P. (2010). Trichomonas vaginalis: underdiagnosis in urban Australia could facilitate re-emergence. Sexually Transmitted Infections, 86(3), 227-230. [More Information]
  • McIver, C., Rismanto, N., Smith, C., Naing, Z., Rayner, B., Lusk, M., Konecny, P., White, P., Rawlinson, W. (2009). Multiplex PCR Testing Detection of Higher-than-Expected Rates of Cervical Mycoplasma, Ureaplasma, and Trichomonas and Viral Agent Infections in Sexually Active Australian Women. Journal of Clinical Microbiology, 47(5), 1358-1363. [More Information]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009). Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal, 423(2), 169-177. [More Information]
  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]
  • Witting, P., Rayner, B., Wu, B., Ellis, N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Witting, P., Rayner, B., Wu, B., Hamilton (Ellis), N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268.
  • Hack, B., Witting, P., Rayner, B., Stocker, R., Headrick, J. (2006). Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine. Molecular and Cellular Biochemistry, 287(1-2), 165-175. [More Information]
  • Rayner, B., Hong Duong, T., Myers, S., Witting, P. (2006). Protective effect of a synthetic anti-oxidant on neuronal cell apoptosis resulting from experimental hypoxia re-oxygenation injury. Journal of Neurochemistry, 97(1), 211-221. [More Information]
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2005). Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. Journal of Biological Chemistry, 280(11), 9985-9993. [More Information]
  • Neuzil, J., Rayner, B., Lowe, H., Witting, P. (2005). Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research. Redox Report, 10(4), 187-197. [More Information]
  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2004). Regulation Of Vascular Tone By S-Nitroso-Myoglobin. Redox Report, 9(6), 382-386.

Conferences

  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2006). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2005). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.

2014

  • Rayner, B., Love, D., Hawkins, C. (2014). Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology and Medicine, 71, 240-255. [More Information]

2013

  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013). Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free Radical Biology and Medicine, 65, 1352-1362. [More Information]
  • Naing, Z., Rayner, B., Killikulangara, A., Vunnam, K., Leach, S., McIver, C., Scott, G., Craig, M., Lui, K., Rawlinson, W. (2013). Prevalence of viruses in stool of premature neonates at a neonatal intensive care unit. Journal of Paediatrics and Child Health, 49(3), e221-e226. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]

2012

  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]

2010

  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Lusk, M., Naing, Z., Rayner, B., Rismanto, N., McIver, C., Cumming, R., McGeechan, K., Rawlinson, W., Konecny, P. (2010). Trichomonas vaginalis: underdiagnosis in urban Australia could facilitate re-emergence. Sexually Transmitted Infections, 86(3), 227-230. [More Information]

2009

  • McIver, C., Rismanto, N., Smith, C., Naing, Z., Rayner, B., Lusk, M., Konecny, P., White, P., Rawlinson, W. (2009). Multiplex PCR Testing Detection of Higher-than-Expected Rates of Cervical Mycoplasma, Ureaplasma, and Trichomonas and Viral Agent Infections in Sexually Active Australian Women. Journal of Clinical Microbiology, 47(5), 1358-1363. [More Information]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009). Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal, 423(2), 169-177. [More Information]
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.

2008

  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]

2007

  • Witting, P., Rayner, B., Wu, B., Ellis, N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Witting, P., Rayner, B., Wu, B., Hamilton (Ellis), N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268.

2006

  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2006). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Hack, B., Witting, P., Rayner, B., Stocker, R., Headrick, J. (2006). Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine. Molecular and Cellular Biochemistry, 287(1-2), 165-175. [More Information]
  • Rayner, B., Hong Duong, T., Myers, S., Witting, P. (2006). Protective effect of a synthetic anti-oxidant on neuronal cell apoptosis resulting from experimental hypoxia re-oxygenation injury. Journal of Neurochemistry, 97(1), 211-221. [More Information]
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]

2005

  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2005). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2005). Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. Journal of Biological Chemistry, 280(11), 9985-9993. [More Information]
  • Neuzil, J., Rayner, B., Lowe, H., Witting, P. (2005). Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research. Redox Report, 10(4), 187-197. [More Information]

2004

  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2004). Regulation Of Vascular Tone By S-Nitroso-Myoglobin. Redox Report, 9(6), 382-386.

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