Dr Ben Rayner

Senior Research Fellow
Sydney Medical School
Postdoctoral Scientist, Inflammation Research Group, Heart Research Institute

Telephone (02) 8208 8900
Fax (02) 9565 5584

Curriculum vitae Curriculum vitae

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Biographical details

Executive Summary: Dr Rayner is a Senior Research Fellow within the Faculty of Medicine at the University of Sydney, employed as a Postdoctoral Research Officer within the Inflammation Group at the Heart Research Institute. Under the supervision of Assoc. Prof. Clare Hawkins, an expert on the role of myeloperoxidase (MPO)-derived oxidative stress within vascular disease, his current research is broadly focused on understanding the key mechanistic elements involved in biological damage derived from MPO oxidant production and the role this damage plays in atherogenesis and myocardial ischaemia reperfusion (I/R) injury (heart attack).

Dr Rayner has a long-held interest in cardiac and vascular research, having commenced employment following his undergraduate degree as a Research Assistant within the Centre for Vascular Research at the University of NSW and shortly thereafter within the Vascular Biology Group at the ANZAC Research Institute / University of Sydney. It was within this environment, under the supervision of University of Sydney Alumni, Assoc. Prof. Paul Witting, a world-recognised expert on oxidative stress, that Dr Rayner completed his PhD studies investigating the efficacy of a synthetic antioxidant within the setting of experimental myocardial I/R injury.

Publications: Dr Rayner has published widely and is currently listed as author of 20 peer-reviewed research papers as well as two invited review articles, all within high-ranking peer-reviewed journals (average impact factor of 3.81). He is acknowledged as primary (first) author of ~ 40% of these papers. A number of his scientific papers have been highly cited including papers published during his PhD (J. Neurochem., 97: 211-221, 2006, cited 55; Cell Physio. Biochem., 20(5): 255-68, 2007, cited 30), which has contributed to his current H-index of 9 (Web of Science). Research Awards /

Grantmanship: As a postdoctoral scientist Dr Rayner has attracted ~ $200,000 in competitive funding including grants from Heart Research Australia (formally North Shore Heart Foundation) and is listed as a co-applicant of a successful RIBG Equipment grant through the University of Sydney. Dr Rayner was awarded a highly competitive National Heart Foundation (NHF) Postgraduate Research Scholarship to undertake his PhD studies and has been successful on numerous occasions in attracting travel grants in order to present his research at local (SFRR, Perth, 2006) and international (SFRR, Christchurch, NZ, 2004; CCAD, Venice, Italy, 2007) meetings. In addition, he has recently been awarded a Young Investigator Award form the Society for Free Radical Research (Nov. 2014).

Contribution to the scientific field: Dr Rayner is a current member of the Society for Free Radical Research and the Society for Free Radical Biology and Medicine and serves as a manuscript reviewer for the journal Free Radical Research. He has previously served as a committee member on the Heart Foundation Collaboration & Exchange Award (CEA, 2014) and Deputy Chairperson of the Royal North Shore Hospital Animal Care and Ethics Committee (ACEC, June 2010 - Dec 2012) and actively engages in the promotion of inter-institute collaborative research through his ongoing role as the Heart Research Institute’s weekly seminar co-ordinator / chairperson.

Relevance to the wider community: In addition to publishing his research outcomes in peer-reviewed journals Dr Rayner’s research towards his PhD has been highlighted in an article published in the Daily Telegraph as part of National Heart Week (Friday May 6, 2005), and his recent research profile has been the focus of a Heart Research Institute “Hearts Matter” fundraising mail-out to current and potential donors (August, 2014).

Current projects

Investigating the role of MPO-derived oxidants in vascular dysfunction associated with atherosclerosis. Assoc. Prof C. Hawkins. Inflammation Group, Heart Research Institute, University of Sydney.

Investigating the role of MPO-derived oxidants in atherosclerosis and heart attack. Assoc. Prof C. Hawkins & Dr. Ben Rayner, Inflammation Group, Heart Research Institute, University of Sydney.

Associations

• Manuscript review panel member for the journal Free Radical Research.

• Heart Foundation Collaboration & Exchange Award (CEA) Committee Member 2014.

• Member Society for Free Radical Research (SFRR) Australasia.

• Member Society for Free Radical Biology and Medicine (SFRBM).

• Heart Research Institute weekly seminar coordinator / chairperson.

• Qualified in venipuncture practice (Pathology Foundation)

• Qualified in First Aid (St John Ambulance Aust.)

Awards and honours

• Awarded a Society for Free Radical Biology and Medicine (SFRBM) Young Investigator Award (November, 2014)

• Rayner, B.S. & Bhindi, R. Heart Research Australia Grant ($148500, 2013-2015): Investigating the molecular mechanisms of remote pre- and post-conditioning within the setting of cardiac ischemia reperfusion injury.

• RIBG Equipment Grant – The FLOID image analyzer distributed by Life Technologies. P Witting, N King, B Hambly, B Rayner, B Freedman, L Kritharides, P Lay, M Bilek, M Davies, L Rendina, A Sharland, G Maghzal, G Sutherland, Rcodd, R Payne. ($14800, 2012)

• Rayner, B.S. & Bhindi, R. North Shore Heart Foundation Research Grant ($48200, 2012): Investigating the role of Egr-1 within the setting of cardiac preconditioning.

• Recipient of an Australian Heart Foundation Travel Award to present current research at the 7th International Congress on Coronary Artery Disease, Venice, Italy (October, 2007).

• Awarded the Society for Free Radical Research (SFRR) Young Investigator Award (December, 2006).

• Recipient of an Australian Heart Foundation Postgraduate Research Scholarship to investigate the effects of synthetic antioxidant supplementation on myocardial ischemia reperfusion injury ($25000 p.a., 2005-2008).

• Recipient of an Australian Heart Foundation Travel Award to present current research at the annual Society for Free Radical Research (Australasia) conference, Christchurch, New Zealand (December, 2004).

• Awarded the Concord Area Health Service Young Researcher of the Year Award (October, 2004).

In the media

Dr Rayner’s research towards his PhD has been highlighted in an article published in the Daily Telegraph as part of National Heart Week (Friday May 6, 2005), and his recent research profile has been the focus of a Heart Research Institute “Hearts Matter” fundraising mail-out to current and potential donors (August, 2014).

Selected grants

2012

  • Egr-1 and cardiac ischemic preconditioning; Bhindi R, Rayner B; North Shore Heart Research Foundation/Research Support.

Selected publications

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Journals

  • Rayner, B., Love, D., Hawkins, C. (2014). Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology and Medicine, 71, 240-255. [More Information]
  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013). Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free Radical Biology and Medicine, 65, 1352-1362. [More Information]
  • Naing, Z., Rayner, B., Killikulangara, A., Vunnam, K., Leach, S., McIver, C., Scott, G., Craig, M., Lui, K., Rawlinson, W. (2013). Prevalence of viruses in stool of premature neonates at a neonatal intensive care unit. Journal of Paediatrics and Child Health, 49(3), e221-e226. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Lusk, M., Naing, Z., Rayner, B., Rismanto, N., McIver, C., Cumming, R., McGeechan, K., Rawlinson, W., Konecny, P. (2010). Trichomonas vaginalis: underdiagnosis in urban Australia could facilitate re-emergence. Sexually Transmitted Infections, 86(3), 227-230. [More Information]
  • McIver, C., Rismanto, N., Smith, C., Naing, Z., Rayner, B., Lusk, M., Konecny, P., White, P., Rawlinson, W. (2009). Multiplex PCR Testing Detection of Higher-than-Expected Rates of Cervical Mycoplasma, Ureaplasma, and Trichomonas and Viral Agent Infections in Sexually Active Australian Women. Journal of Clinical Microbiology, 47(5), 1358-1363. [More Information]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009). Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal, 423(2), 169-177. [More Information]
  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]
  • Witting, P., Rayner, B., Wu, B., Ellis, N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Witting, P., Rayner, B., Wu, B., Hamilton (Ellis), N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268.
  • Hack, B., Witting, P., Rayner, B., Stocker, R., Headrick, J. (2006). Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine. Molecular and Cellular Biochemistry, 287(1-2), 165-175. [More Information]
  • Rayner, B., Hong Duong, T., Myers, S., Witting, P. (2006). Protective effect of a synthetic anti-oxidant on neuronal cell apoptosis resulting from experimental hypoxia re-oxygenation injury. Journal of Neurochemistry, 97(1), 211-221. [More Information]
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2005). Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. Journal of Biological Chemistry, 280(11), 9985-9993. [More Information]
  • Neuzil, J., Rayner, B., Lowe, H., Witting, P. (2005). Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research. Redox Report, 10(4), 187-197. [More Information]
  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2004). Regulation Of Vascular Tone By S-Nitroso-Myoglobin. Redox Report, 9(6), 382-386.

Conferences

  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2006). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2005). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.

2014

  • Rayner, B., Love, D., Hawkins, C. (2014). Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology and Medicine, 71, 240-255. [More Information]

2013

  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013). Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. Free Radical Biology and Medicine, 65, 1352-1362. [More Information]
  • Naing, Z., Rayner, B., Killikulangara, A., Vunnam, K., Leach, S., McIver, C., Scott, G., Craig, M., Lui, K., Rawlinson, W. (2013). Prevalence of viruses in stool of premature neonates at a neonatal intensive care unit. Journal of Paediatrics and Child Health, 49(3), e221-e226. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]

2012

  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]

2010

  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Lusk, M., Naing, Z., Rayner, B., Rismanto, N., McIver, C., Cumming, R., McGeechan, K., Rawlinson, W., Konecny, P. (2010). Trichomonas vaginalis: underdiagnosis in urban Australia could facilitate re-emergence. Sexually Transmitted Infections, 86(3), 227-230. [More Information]

2009

  • McIver, C., Rismanto, N., Smith, C., Naing, Z., Rayner, B., Lusk, M., Konecny, P., White, P., Rawlinson, W. (2009). Multiplex PCR Testing Detection of Higher-than-Expected Rates of Cervical Mycoplasma, Ureaplasma, and Trichomonas and Viral Agent Infections in Sexually Active Australian Women. Journal of Clinical Microbiology, 47(5), 1358-1363. [More Information]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009). Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal, 423(2), 169-177. [More Information]
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.

2008

  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]

2007

  • Witting, P., Rayner, B., Wu, B., Ellis, N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Witting, P., Rayner, B., Wu, B., Hamilton (Ellis), N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268.

2006

  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2006). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Hack, B., Witting, P., Rayner, B., Stocker, R., Headrick, J. (2006). Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine. Molecular and Cellular Biochemistry, 287(1-2), 165-175. [More Information]
  • Rayner, B., Hong Duong, T., Myers, S., Witting, P. (2006). Protective effect of a synthetic anti-oxidant on neuronal cell apoptosis resulting from experimental hypoxia re-oxygenation injury. Journal of Neurochemistry, 97(1), 211-221. [More Information]
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]

2005

  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2005). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2005). Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. Journal of Biological Chemistry, 280(11), 9985-9993. [More Information]
  • Neuzil, J., Rayner, B., Lowe, H., Witting, P. (2005). Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research. Redox Report, 10(4), 187-197. [More Information]

2004

  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2004). Regulation Of Vascular Tone By S-Nitroso-Myoglobin. Redox Report, 9(6), 382-386.

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