Associate Professor Beric Henderson

Principal Research Fellow
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 9057
Fax +61 2 9845 9012

Website Related website

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PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

Selected grants

2014

  • Regulation of cancer-associated proteins; Henderson B; DVC Research/Bridging Support Fellowship.

2013

  • Characterising the beta-catenin nuclear targeting pathway in cancer; Henderson B, Molloy M, Forwood J, Sharma M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Defining new tumour suppressor regulatory pathways in cancer; Henderson B; Cancer Institute New South Wales/Career Development Fellowship.
  • Role of specific BARD1 splice variant isoforms in tumour cell resistance to DNA damage agents; Henderson B; National Breast Cancer Foundation/Novel Concept Awards.
  • IncuCyte ZOOM; Rizos H, deFazio A, Mann G, Henderson B; DVC Research/Equipment Grant.

2012

  • Regulation of BRCA1 Dynamics and Function at Nuclear DNA Repair Complexes; Henderson B; DVC Research/Bridging Support Grant.
  • Novel regulation of beta-catenin intracellular transport and its role in cell polarity and migration; Sharma M, Henderson B; Cancer Council New South Wales/Research Project Grants.

2011

  • Regulation of APC intracellular dynamics and function; Henderson B, Brocardo M, Molloy M; Cancer Council New South Wales/Research Project Grants.
  • Regulation of the dynamics and function of BRCA1 at centrosomes and nuclear DNA repair complexes; Henderson B; DVC Research/Bridging Support Grant.

2010

  • The effect of colon cancer mutations on APC dynamics and function at the centrosome; Henderson B; Cancer Institute New South Wales/Research Innovation Grants.
  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Regulated shuttling of beta-catenin and IQGAP1 between nucleus and plasma membrane in migrating cells; Henderson B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • High-Throughput virtual microscopy and data warehouse system; Mann G, Schifter M, Balleine R, George J, Henderson B, Clarke C, Catchpoole D, deFazio A; Cancer Institute New South Wales/Equipment Grant.
  • Deltavision (DV) Core Image Restoration; Cunningham A, Turville S, Clarke C, Henderson B, Kefford R, North K, O'Neill G, Murray R, Reddel R, Tam P, Robinson P, Chircop M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Dynamics and assembly of BRCA1-associated DNA repair complexes; Henderson B; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • Targeting of the APC tumour suppressor to mitochondria: Implications for APC regulation and cellular function; Henderson B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mitochondrial targeting of the DNA repair protein BARD1; Henderson B, Rizos H; Australian Research Council (ARC)/Discovery Projects (DP).
  • Senior Research Fellowship A; Henderson B; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

2007

  • Confocal microscope for cancer research in the northern hub; Robinson P, Gunning P, Hardeman E, Henderson B, Bendall L, Chircop (nee Fabbro) M; Cancer Institute New South Wales/Research Grant.
  • Flow Cytometry support; Alexander S, Braithwaite A, Bradstock K, Bendall L, Gunning P, Henderson B, Kefford R, Reddel R, Rizos H, Jones C, Byrne J; Cancer Institute New South Wales/Infrastructure Grant.

2006

  • Regulation of beta-catenin localisation and its role in tumour cell migration; Henderson B, Bendall L; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Characterisation of APC intracellular trafficking pathways; Henderson B; Australian Research Council (ARC)/Discovery Projects (DP).
  • Regulation of BARD1 localisation and apoptotic function in breast cancer; Henderson B; Cancer Council New South Wales/Research Project Grants.
  • Regulation of BARD1 localisation and apoptotic function in breast cancer; Henderson B; National Breast Cancer Foundation/Kathleen Cuningham Research Grants Program.

2005

  • Regulated targeting of BRCA 1 to nuclear sites of DNA repair; Henderson B; Cancer Council New South Wales/Research Project Grants.

2004

  • Regulation of BARD1 subcellular localisation and apoptotic function; Henderson B; University of Sydney/Cancer Research Fund.
  • Zeiss axiovert 200M cell observer system; Henderson B, Cunningham A, Farrell G, Clarke C, Diefenbach R, Kefford R, Rizos H; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • Role of the microtubule cytoskeleton in APC-dependent transport of beta-catenin; Henderson B; Cure Cancer Australia Foundation/Research Support.
  • Regulation of BRCA1 and APC tumour suppressor functions by nuclear export?; Henderson B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Oncology Research; Henderson B; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

2002

  • Regulation of beta-catenin nuclear trafficking in cancer; Henderson B; Cancer Council New South Wales/Research Project Grants.

2000

  • A novel nuclear import pathway for proteins; Henderson B; Leo and Jenny Leukaemia and Cancer Foundation/Grant Series.
  • Regulation of the tumour suppressors APC and BRCA1 by nuclear export; Henderson B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Regulation of BRCA1 nuclear transport in breast tumour cells; Henderson B; Leo and Jenny Leukaemia and Cancer Foundation/Leukaemia and Cancer Foundation.

Selected publications

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Book Chapters

  • Sharma, M., Johnson, M., Brocardo, M., Jamieson, C., Henderson, B. (2014). Wnt Signaling Proteins Associate with the Nuclear Pore Complex: Implications for Cancer. In Eric C. Schirmer, and Jose I. de las Heras (Eds.), Cancer Biology and the Nuclear Envelope, (pp. 353-372). New York: Springer.
  • Sharma, M., Henderson, B. (2010). Methods to Measure Nuclear Export of Beta-Catenin Using Fixed and Live Cell Assays. In Paul J. Higgins (Eds.), Transcription Factors: Methods and Protocols - Methods in Molecular Biology Volume 647, (pp. 187-197). United States: Humana Press.
  • Brocardo, M., Henderson, B. (2008). Detection of cytoplasmic and nuclear localization of adenomatous polyposis coli (APC) protein in cells. In Elizabeth Vincan, John M. Walker (Eds.), Methods in Molecular Biology 468: Wnt Signaling, Volume 1: Pathway Methods and Mammalian Models, (pp. 77-89). New York: Humana Press. [More Information]

Journals

  • Johnson, M., Sharma, M., Mok, M., Henderson, B. (2013). Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1833 (10), 2334-2347. [More Information]
  • Mok, M., Henderson, B. (2012). A two-step fluorescence-activated cell sorting approach to isolate genetically modified mammalian cells with isopropyl-beta-D-thiogalactoside (IPTG)-inducible gene expression. Cytometry Part A, 81A(2), 101-104. [More Information]
  • Lui, C., Mills, K., Brocardo, M., Sharma, M., Henderson, B. (2012). APC as a Mobile Scaffold: Regulation and Function at the Nucleus, Centrosomes, and Mitochondria. IUBMB Life, 64(3), 209-214. [More Information]
  • Brodie, K., Mok, M., Henderson, B. (2012). Characterization of BARD1 targeting and dynamics at the centrosome: the role of CRM1, BRCA1 and the Q564H mutation. Cellular Signalling, 24(2), 451-459. [More Information]
  • Brodie, K., Henderson, B. (2012). Characterization of BRCA1 Protein Targeting, Dynamics, and Function at the Centrosome: a Role for the Nuclear Export Signal, CRM1, and Aurora A Kinase. Journal of Biological Chemistry, 287(10), 7701-7716. [More Information]
  • Sharma, M., Jamieson, C., Johnson, M., Molloy, M., Henderson, B. (2012). Specific Armadillo Repeat Sequences Facilitate beta-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358. Journal of Biological Chemistry, 287(2), 819-831. [More Information]
  • Mok, M., Henderson, B. (2012). The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci. The International Journal of Biochemistry and Cell Biology, 44(9), 1398-1409. [More Information]
  • Mok, M., Henderson, B. (2012). The In Vivo Dynamic Organization of BRCA1-A Complex Proteins at DNA Damage-Induced Nuclear Foci. Traffic (Malden), 13(6), 800-814. [More Information]
  • Johnson, M., Henderson, B. (2012). The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation. Bioarchitecture, 2(4), 138-142. [More Information]
  • Mok, M., Henderson, B. (2012). Three-dimensional imaging reveals the spatial separation of γH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci. Radiotherapy and Oncology, 103(3), 415-420. [More Information]
  • Jamieson, C., Sharma, M., Henderson, B. (2012). Wnt signaling from membrane to nucleus: β-catenin caught in a loop. The International Journal of Biochemistry and Cell Biology, 44(6), 847-850. [More Information]
  • Brocardo, M., Borowiec, J., Henderson, B. (2011). Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. The International Journal of Biochemistry and Cell Biology, 43(9), 1354-1364. [More Information]
  • Johnson, M., Sharma, M., Brocardo, M., Henderson, B. (2011). IQGAP1 Translocates to the Nucleus in Early S-Phase and Contributes to Cell Cycle Progression After DNA Replication Arrest. The International Journal of Biochemistry and Cell Biology, 43(1), 65-73. [More Information]
  • Jamieson, C., Sharma, M., Henderson, B. (2011). Regulation of β-Catenin Nuclear Dynamics by GSK-3β Involves a LEF-1 Positive Feedback Loop. Traffic (Malden), 12(8), 983-999. [More Information]
  • Mok, M., Henderson, B. (2010). A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci. Cellular Signalling, 22(1), 47-56. [More Information]
  • Henderson, B. (2010). Cryptic mitochondrial targeting signals in human ARF: Clues to controlling cancer? Cell Cycle, 9(5), 866-867. [More Information]
  • Brodie, K., Henderson, B. (2010). Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage. Cellular Signalling, 22(2), 291-302. [More Information]
  • Flegg, C., Sharma, M., Medina-Palazon, C., Jamieson, C., Galea, M., Brocardo, M., Mills, K., Henderson, B. (2010). Nuclear Export and Centrosome Targeting of the Protein Phosphatase 2A Subunit B56alpha: Role of B56alpha in Nuclear Export of the Catalytic Subunit. Journal of Biological Chemistry, 285(24), 18144-18154. [More Information]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Johnson, M., Sharma, M., Henderson, B. (2009). IQGAP1 regulation and roles in cancer. Cellular Signalling. [More Information]
  • Manniccia, A., Lewis, C., Begum, N., Xu, J., Cui, J., Chipitsyna, G., Aysola, K., Reddy, V., Bhat, G., Fujimura, Y., Henderson, B., et al (2009). Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins. Journal of Cellular Physiology, 219(3), 634-641. [More Information]
  • Johnson, M., Sharma, M., Jamieson, C., Henderson, J., Mok, M., Bendall, L., Henderson, B. (2009). Regulation of beta-catenin trafficking to the membrane in living cells. Cellular Signalling, 21(2), 339-348. [More Information]
  • Brocardo, M., Henderson, B. (2008). APC shuttling to the membrane, nucleus and beyond. Trends in Cell Biology, 18(12), 587-596. [More Information]
  • Chircop (nee Fabbro), M., Henderson, B. (2008). BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters. Cancer Letters, 263(2), 189-196. [More Information]
  • Brocardo, M., Lei, Y., Tighe, A., Taylor, S., Mok, M., Henderson, B. (2008). Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: Regulation of Bcl-2 and implications for cell survival. Journal of Biological Chemistry, 283(9), 5950-5959. [More Information]
  • Zanella, F., Rosado, A., Blanco, F., Henderson, B., Carnero, A., Link, W. (2007). An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays. ASSAY and Drug Development Technologies, 5(3), 333-341.
  • Tembe, V., Henderson, B. (2007). BARD1 Translocation to Mitochondria Correlates with Bax Oligomerization, Loss of Mitochondrial Membrane Potential, and Apoptosis. Journal of Biological Chemistry, 282(28), 20513-20522. [More Information]
  • Bolli, N., Nicoletti, I., De Marco, M., Bigerna, B., Pucciarini, A., Mannucci, R., Martelli, M., Liso, A., Mecucci, C., Fabbiano, F., Henderson, B., et al (2007). Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants. Cancer Research, 67(13), 6230-6237.
  • Lovelock, P., Spurdle, A., Mok, M., Farrugia, D., Lakhani, S., Healey, S., Arnold, S., Buchanan, D., kConFab Investigators., Couch, F., Henderson, B., et al (2007). Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants? Breast Cancer Research, 9(6), 1-13. [More Information]
  • Au, W., Henderson, B. (2007). Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. Cellular Signalling, 19(9), 1879-1892. [More Information]
  • Sharma, M., Henderson, B. (2007). IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. Journal of Biological Chemistry, 282(11), 8545-8556. [More Information]
  • Tembe, V., Henderson, B. (2007). Protein trafficking in response to DNA damage. Cellular Signalling, 19(6), 1113-1120. [More Information]
  • Lovelock, P., Healey, S., Au, W., Sum, E., Tesoriero, A., Wong, E., Hinson, S., Brinkworth, R., Bekessy, A., Diez, O., Henderson, B., et al (2006). Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants. Journal of Medical Genetics, 43(1), 74-83.
  • Sharma, M., Leung, L., Brocardo, M., Henderson, J., Flegg, C., Henderson, B. (2006). Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. Journal of Biological Chemistry, 281(25), 17140-17149. [More Information]
  • Schüchner, S., Tembe, V., Rodriguez, J., Henderson, B. (2005). Nuclear targeting and cell cycle regulatory function of human BARD1. Journal of Biological Chemistry, 280(10), 8855-8861. [More Information]
  • Brocardo, M., Näthke, I., Henderson, B. (2005). Redefining the subcellular location and transport of APC: new insights using a panel of antibodies. EMBO Reports, 6(2), 184-90. [More Information]
  • Henderson, B. (2005). Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking. BioEssays, 27(9), 884-893. [More Information]
  • Au, W., Henderson, B. (2005). The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci. Journal of Biological Chemistry, 280(8), 6993-7001.
  • Chircop (nee Fabbro), M., Schuechner, S., Au, W., Henderson, B. (2004). Bard1 Regulates Brca1 Apoptotic Function By A Mechanism Involving Nuclear Retention. Experimental Cell Research: emphasizing molecular approaches to cell biology, 298(2), 661-673.
  • Rodriguez, J., Au, W., Henderson, B. (2004). Cytoplasmic Mislocalization Of Brca1 Caused By Cancer-Associated Mutations In The Brct Domain. Experimental Cell Research: emphasizing molecular approaches to cell biology, 293(1), 14-21.
  • Rodriguez, J., Schuchner, S., Au, W., Chircop (nee Fabbro), M., Henderson, B. (2004). Nuclear-Cytoplasmic Shuttling Of Bard1 Contributes To Its Proapoptotic Activity And Is Regulated By Dimerization With Brca1. Oncogene, 23(10), 1809-1820.
  • Keough, R., Macmillan, E., Lutwyche, J., Gardner, J., Tavner, F., Jans, D., Henderson, B., Gonda, T. (2003). Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes crm1-dependent and independent nuclear export pathways. Experimental Cell Research: emphasizing molecular approaches to cell biology, 289(1), 108-123.
  • Henderson, B. (2003). Nuclear transport as a target for cancer therapies. Drug Discovery Today, 8(6), 249.
  • Chircop (nee Fabbro), M., Henderson, B. (2003). Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Experimental Cell Research: emphasizing molecular approaches to cell biology, 282(2), 59-69.
  • Chircop (nee Fabbro), M., Rodriguez, J., Baer, R., Henderson, B. (2002). BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export. Journal of Biological Chemistry, 277(24), 21315-21324.
  • Henderson, B., Galea, M., Schuechner, S., Leung, L. (2002). Lymphoid enhancer factor-1 blocks adenomators polyposis coli-mediated nuclear export and degradation of B-catenin. Journal of Biological Chemistry, 277(27), 24258-24264.
  • Henderson, B., Fagotto, F. (2002). The ins and outs of APC and B-catenin nuclear transport. EMBO Reports, 3(9), 834-839.
  • Galea, M., Henderson, B., Eleftheriou, A. (2001). ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by B56a subunit of protein phosphatase 2A. Journal of Biological Chemistry, 276, 45833-45839.
  • Lam, M., Henderson, B., Gillespie, M., Jans, D. (2001). Dynamics of Leptomycin B-sensitive nucleocytoplasmic flux of parathyroid hormone-related protein. Traffic: the international journal of intracellular transport, 2(11), 812-819.
  • Lixin, R., Efthymiadis, A., Henderson, B., Jans, D. (2001). Novel properties of the nucleolar targeting signal of human angiogenin. Biochemical and Biophysical Research Communications, 284(1), 185-193.
  • Eleftheriou, A., Yoshida,, M., Henderson, B. (2001). Nuclear Export of Human B-Catenin can occur independent of CRM1 and the Adenomatous Polyposis Coli Tumor Suppresor. Journal of Biological Chemistry, 276(28), 25883-25888.
  • Henderson, B., Eleftheriou, A. (2000). A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals. Experimental Cell Research: emphasizing molecular approaches to cell biology, 256(1), 213-224.
  • Rodriguez, J., Henderson, B. (2000). Identification of a functional nuclear export sequence in BRCA1. Journal of Biological Chemistry, 275(49), 38589-38596.

Conferences

  • Brodie, K., Henderson, B. (2012). Regulation of BRCA1/BARD1 dynamics and function at the centrosome. ComBio2012, Adelaide, SA.
  • Henderson, B., Brocardo, M., Medina-Palazon, C. (2010). Regulated Trafficking of the APC tumour suppressor to mitochondria, nucleus, centosomes and beyond. Ozbio - Protein trafficking session, Melbourne.
  • Henderson, B. (2010). Regulation of BRCA1 dynamics and breast cancer. 3rd China-University of Sydney Symposium and University Expo, Shanghai.
  • Henderson, B. (2010). Regulation of BRCA1 in breast cancer. 3rd Annual World Cancer Congress, Breast Cancer Conference, Shanghai: BIT.
  • Henderson, B. (2008). BRCA1 redistribution in response to DNA damage. 4th Australian Health and Medical Research Congress (AHMRC), Brisbane: The Australian Society for Medical Research.
  • Henderson, B. (2008). Movement of tumour suppressor proteins to mitochondria. AussieMit, Mitochondrial Research conference, Melbourne.

2014

  • Sharma, M., Johnson, M., Brocardo, M., Jamieson, C., Henderson, B. (2014). Wnt Signaling Proteins Associate with the Nuclear Pore Complex: Implications for Cancer. In Eric C. Schirmer, and Jose I. de las Heras (Eds.), Cancer Biology and the Nuclear Envelope, (pp. 353-372). New York: Springer.

2013

  • Johnson, M., Sharma, M., Mok, M., Henderson, B. (2013). Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1833 (10), 2334-2347. [More Information]

2012

  • Mok, M., Henderson, B. (2012). A two-step fluorescence-activated cell sorting approach to isolate genetically modified mammalian cells with isopropyl-beta-D-thiogalactoside (IPTG)-inducible gene expression. Cytometry Part A, 81A(2), 101-104. [More Information]
  • Lui, C., Mills, K., Brocardo, M., Sharma, M., Henderson, B. (2012). APC as a Mobile Scaffold: Regulation and Function at the Nucleus, Centrosomes, and Mitochondria. IUBMB Life, 64(3), 209-214. [More Information]
  • Brodie, K., Mok, M., Henderson, B. (2012). Characterization of BARD1 targeting and dynamics at the centrosome: the role of CRM1, BRCA1 and the Q564H mutation. Cellular Signalling, 24(2), 451-459. [More Information]
  • Brodie, K., Henderson, B. (2012). Characterization of BRCA1 Protein Targeting, Dynamics, and Function at the Centrosome: a Role for the Nuclear Export Signal, CRM1, and Aurora A Kinase. Journal of Biological Chemistry, 287(10), 7701-7716. [More Information]
  • Brodie, K., Henderson, B. (2012). Regulation of BRCA1/BARD1 dynamics and function at the centrosome. ComBio2012, Adelaide, SA.
  • Sharma, M., Jamieson, C., Johnson, M., Molloy, M., Henderson, B. (2012). Specific Armadillo Repeat Sequences Facilitate beta-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358. Journal of Biological Chemistry, 287(2), 819-831. [More Information]
  • Mok, M., Henderson, B. (2012). The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci. The International Journal of Biochemistry and Cell Biology, 44(9), 1398-1409. [More Information]
  • Mok, M., Henderson, B. (2012). The In Vivo Dynamic Organization of BRCA1-A Complex Proteins at DNA Damage-Induced Nuclear Foci. Traffic (Malden), 13(6), 800-814. [More Information]
  • Johnson, M., Henderson, B. (2012). The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation. Bioarchitecture, 2(4), 138-142. [More Information]
  • Mok, M., Henderson, B. (2012). Three-dimensional imaging reveals the spatial separation of γH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci. Radiotherapy and Oncology, 103(3), 415-420. [More Information]
  • Jamieson, C., Sharma, M., Henderson, B. (2012). Wnt signaling from membrane to nucleus: β-catenin caught in a loop. The International Journal of Biochemistry and Cell Biology, 44(6), 847-850. [More Information]

2011

  • Brocardo, M., Borowiec, J., Henderson, B. (2011). Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. The International Journal of Biochemistry and Cell Biology, 43(9), 1354-1364. [More Information]
  • Johnson, M., Sharma, M., Brocardo, M., Henderson, B. (2011). IQGAP1 Translocates to the Nucleus in Early S-Phase and Contributes to Cell Cycle Progression After DNA Replication Arrest. The International Journal of Biochemistry and Cell Biology, 43(1), 65-73. [More Information]
  • Jamieson, C., Sharma, M., Henderson, B. (2011). Regulation of β-Catenin Nuclear Dynamics by GSK-3β Involves a LEF-1 Positive Feedback Loop. Traffic (Malden), 12(8), 983-999. [More Information]

2010

  • Mok, M., Henderson, B. (2010). A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci. Cellular Signalling, 22(1), 47-56. [More Information]
  • Henderson, B. (2010). Cryptic mitochondrial targeting signals in human ARF: Clues to controlling cancer? Cell Cycle, 9(5), 866-867. [More Information]
  • Brodie, K., Henderson, B. (2010). Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage. Cellular Signalling, 22(2), 291-302. [More Information]
  • Sharma, M., Henderson, B. (2010). Methods to Measure Nuclear Export of Beta-Catenin Using Fixed and Live Cell Assays. In Paul J. Higgins (Eds.), Transcription Factors: Methods and Protocols - Methods in Molecular Biology Volume 647, (pp. 187-197). United States: Humana Press.
  • Flegg, C., Sharma, M., Medina-Palazon, C., Jamieson, C., Galea, M., Brocardo, M., Mills, K., Henderson, B. (2010). Nuclear Export and Centrosome Targeting of the Protein Phosphatase 2A Subunit B56alpha: Role of B56alpha in Nuclear Export of the Catalytic Subunit. Journal of Biological Chemistry, 285(24), 18144-18154. [More Information]
  • Henderson, B., Brocardo, M., Medina-Palazon, C. (2010). Regulated Trafficking of the APC tumour suppressor to mitochondria, nucleus, centosomes and beyond. Ozbio - Protein trafficking session, Melbourne.
  • Henderson, B. (2010). Regulation of BRCA1 dynamics and breast cancer. 3rd China-University of Sydney Symposium and University Expo, Shanghai.
  • Henderson, B. (2010). Regulation of BRCA1 in breast cancer. 3rd Annual World Cancer Congress, Breast Cancer Conference, Shanghai: BIT.

2009

  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Johnson, M., Sharma, M., Henderson, B. (2009). IQGAP1 regulation and roles in cancer. Cellular Signalling. [More Information]
  • Manniccia, A., Lewis, C., Begum, N., Xu, J., Cui, J., Chipitsyna, G., Aysola, K., Reddy, V., Bhat, G., Fujimura, Y., Henderson, B., et al (2009). Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins. Journal of Cellular Physiology, 219(3), 634-641. [More Information]
  • Johnson, M., Sharma, M., Jamieson, C., Henderson, J., Mok, M., Bendall, L., Henderson, B. (2009). Regulation of beta-catenin trafficking to the membrane in living cells. Cellular Signalling, 21(2), 339-348. [More Information]

2008

  • Brocardo, M., Henderson, B. (2008). APC shuttling to the membrane, nucleus and beyond. Trends in Cell Biology, 18(12), 587-596. [More Information]
  • Chircop (nee Fabbro), M., Henderson, B. (2008). BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters. Cancer Letters, 263(2), 189-196. [More Information]
  • Henderson, B. (2008). BRCA1 redistribution in response to DNA damage. 4th Australian Health and Medical Research Congress (AHMRC), Brisbane: The Australian Society for Medical Research.
  • Brocardo, M., Henderson, B. (2008). Detection of cytoplasmic and nuclear localization of adenomatous polyposis coli (APC) protein in cells. In Elizabeth Vincan, John M. Walker (Eds.), Methods in Molecular Biology 468: Wnt Signaling, Volume 1: Pathway Methods and Mammalian Models, (pp. 77-89). New York: Humana Press. [More Information]
  • Brocardo, M., Lei, Y., Tighe, A., Taylor, S., Mok, M., Henderson, B. (2008). Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: Regulation of Bcl-2 and implications for cell survival. Journal of Biological Chemistry, 283(9), 5950-5959. [More Information]
  • Henderson, B. (2008). Movement of tumour suppressor proteins to mitochondria. AussieMit, Mitochondrial Research conference, Melbourne.

2007

  • Zanella, F., Rosado, A., Blanco, F., Henderson, B., Carnero, A., Link, W. (2007). An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays. ASSAY and Drug Development Technologies, 5(3), 333-341.
  • Tembe, V., Henderson, B. (2007). BARD1 Translocation to Mitochondria Correlates with Bax Oligomerization, Loss of Mitochondrial Membrane Potential, and Apoptosis. Journal of Biological Chemistry, 282(28), 20513-20522. [More Information]
  • Bolli, N., Nicoletti, I., De Marco, M., Bigerna, B., Pucciarini, A., Mannucci, R., Martelli, M., Liso, A., Mecucci, C., Fabbiano, F., Henderson, B., et al (2007). Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants. Cancer Research, 67(13), 6230-6237.
  • Lovelock, P., Spurdle, A., Mok, M., Farrugia, D., Lakhani, S., Healey, S., Arnold, S., Buchanan, D., kConFab Investigators., Couch, F., Henderson, B., et al (2007). Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants? Breast Cancer Research, 9(6), 1-13. [More Information]
  • Au, W., Henderson, B. (2007). Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. Cellular Signalling, 19(9), 1879-1892. [More Information]
  • Sharma, M., Henderson, B. (2007). IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. Journal of Biological Chemistry, 282(11), 8545-8556. [More Information]
  • Tembe, V., Henderson, B. (2007). Protein trafficking in response to DNA damage. Cellular Signalling, 19(6), 1113-1120. [More Information]

2006

  • Lovelock, P., Healey, S., Au, W., Sum, E., Tesoriero, A., Wong, E., Hinson, S., Brinkworth, R., Bekessy, A., Diez, O., Henderson, B., et al (2006). Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants. Journal of Medical Genetics, 43(1), 74-83.
  • Sharma, M., Leung, L., Brocardo, M., Henderson, J., Flegg, C., Henderson, B. (2006). Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. Journal of Biological Chemistry, 281(25), 17140-17149. [More Information]

2005

  • Schüchner, S., Tembe, V., Rodriguez, J., Henderson, B. (2005). Nuclear targeting and cell cycle regulatory function of human BARD1. Journal of Biological Chemistry, 280(10), 8855-8861. [More Information]
  • Brocardo, M., Näthke, I., Henderson, B. (2005). Redefining the subcellular location and transport of APC: new insights using a panel of antibodies. EMBO Reports, 6(2), 184-90. [More Information]
  • Henderson, B. (2005). Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking. BioEssays, 27(9), 884-893. [More Information]
  • Au, W., Henderson, B. (2005). The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci. Journal of Biological Chemistry, 280(8), 6993-7001.

2004

  • Chircop (nee Fabbro), M., Schuechner, S., Au, W., Henderson, B. (2004). Bard1 Regulates Brca1 Apoptotic Function By A Mechanism Involving Nuclear Retention. Experimental Cell Research: emphasizing molecular approaches to cell biology, 298(2), 661-673.
  • Rodriguez, J., Au, W., Henderson, B. (2004). Cytoplasmic Mislocalization Of Brca1 Caused By Cancer-Associated Mutations In The Brct Domain. Experimental Cell Research: emphasizing molecular approaches to cell biology, 293(1), 14-21.
  • Rodriguez, J., Schuchner, S., Au, W., Chircop (nee Fabbro), M., Henderson, B. (2004). Nuclear-Cytoplasmic Shuttling Of Bard1 Contributes To Its Proapoptotic Activity And Is Regulated By Dimerization With Brca1. Oncogene, 23(10), 1809-1820.

2003

  • Keough, R., Macmillan, E., Lutwyche, J., Gardner, J., Tavner, F., Jans, D., Henderson, B., Gonda, T. (2003). Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes crm1-dependent and independent nuclear export pathways. Experimental Cell Research: emphasizing molecular approaches to cell biology, 289(1), 108-123.
  • Henderson, B. (2003). Nuclear transport as a target for cancer therapies. Drug Discovery Today, 8(6), 249.
  • Chircop (nee Fabbro), M., Henderson, B. (2003). Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Experimental Cell Research: emphasizing molecular approaches to cell biology, 282(2), 59-69.

2002

  • Chircop (nee Fabbro), M., Rodriguez, J., Baer, R., Henderson, B. (2002). BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export. Journal of Biological Chemistry, 277(24), 21315-21324.
  • Henderson, B., Galea, M., Schuechner, S., Leung, L. (2002). Lymphoid enhancer factor-1 blocks adenomators polyposis coli-mediated nuclear export and degradation of B-catenin. Journal of Biological Chemistry, 277(27), 24258-24264.
  • Henderson, B., Fagotto, F. (2002). The ins and outs of APC and B-catenin nuclear transport. EMBO Reports, 3(9), 834-839.

2001

  • Galea, M., Henderson, B., Eleftheriou, A. (2001). ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by B56a subunit of protein phosphatase 2A. Journal of Biological Chemistry, 276, 45833-45839.
  • Lam, M., Henderson, B., Gillespie, M., Jans, D. (2001). Dynamics of Leptomycin B-sensitive nucleocytoplasmic flux of parathyroid hormone-related protein. Traffic: the international journal of intracellular transport, 2(11), 812-819.
  • Lixin, R., Efthymiadis, A., Henderson, B., Jans, D. (2001). Novel properties of the nucleolar targeting signal of human angiogenin. Biochemical and Biophysical Research Communications, 284(1), 185-193.
  • Eleftheriou, A., Yoshida,, M., Henderson, B. (2001). Nuclear Export of Human B-Catenin can occur independent of CRM1 and the Adenomatous Polyposis Coli Tumor Suppresor. Journal of Biological Chemistry, 276(28), 25883-25888.

2000

  • Henderson, B., Eleftheriou, A. (2000). A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals. Experimental Cell Research: emphasizing molecular approaches to cell biology, 256(1), 213-224.
  • Rodriguez, J., Henderson, B. (2000). Identification of a functional nuclear export sequence in BRCA1. Journal of Biological Chemistry, 275(49), 38589-38596.

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