Professor Bernard Balleine

Professor
Brain & Mind Research Institute, School of Medical Sciences

Telephone +61 2 9114 4011

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Research interests

Professor Balleine’s research aims to understand the neural bases of the learning and motivational processes that control volitional, or goal-directed, action, an issue that has direct bearing on our developing understanding of the role that the integration of cognitive and emotional systems plays in executive functions and decision-making. Currently his research team is focusing on three primary issues: [1] The role of the prefrontal cortex-basal ganglia network in the changes in goal-directed learning that emerge as a consequence of neurodegeneration, focal brain damage and addiction; [2] The role of the amygdala, its brain stem afferents and its efferents on ventral striatum, insular cortex and midbrain dopamine neurons in regulating the emotional processes through which the reward value of events is encoded; and [3] The role of the thalamo-striatal projection and related cortical connections involving somatosensory cortex in the integration of cognitive and emotional processes necessary for normal decision-making.

Selected grants

2015

  • Disorders of action control and learning-related plasticity in the basal ganglia; Balleine B, Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Dysfunctions in decision-making and the cognitive control of action; Balleine B, Chieng B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Dementia related deficits in striatal cholinergic function and decision-making; Balleine B, Bradfield L; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • The development of animal models for Parkinson's disease to study the anti-inflammatory effects of amine oxidase inhibitors; Balleine B; Australian Government: Department of Industry/Enterprise Connect - Researchers in Business.
  • The role of the striatum in disorder of action control; Balleine B; DVC Research/Bridging Support Grant.

2013

  • Sydney Neuroscience Network; Balleine B, Absalom N, Braddon-Mitchell D, Callaghan S, Chawla S, Christie M, Collins M, Einfeld S, Grieve S, Haber P, Hanrahan J, Harris A, Hickie I, Kassiou M, Kril J, Meikle S, Morris R, Ramos F, Rong Y, Sue C; DVC Research/Research Network Scheme (SyReNS).
  • The role of inhibitory conditioning in choice and decision-making; Laurent V, Balleine B; Australian Research Council (ARC)/Discovery Projects (DP).
  • Pathologies of action control: Amygdala-striatal interactions and the development of habits.; Balleine B, Chieng B; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Action-related learning and plasticity in the cortico-striatal network; Balleine B, Christie M; Australian Research Council (ARC)/Discovery Projects (DP).

2010

  • Examining the impact of cocaine-paired cues on goal-directed action selection; Ostlund S, Balleine B; DVC Research/Postdoctoral Research Fellowship Scheme.
  • Action-reward integration in the amygdalocortical-striatal network; Balleine B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Methamphetamine-induced habits and the re-establishment of behavioural control; Balleine B, Killcross S; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • The Neural Basis of Instrumental Action; Balleine B; National Institutes of Health/Research Support.
  • The neural bases of decision-making; Balleine B; Australian Research Council (ARC)/Australian Laureate Fellowships (FL).
  • Alcohol, Habit and the Failure of Behavioral Control; Balleine B; National Institute on Drug Abuse (USA)/Research Grant.
  • Cortico-striatal Circuits in Actions and Habits; Balleine B; National Institutes of Health (USA)/Research Support.

Selected publications

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Book Chapters

  • O'Doherty, J., Balleine, B. (2012). Neural bases of actions and habits. In Peter M. Todd, Thomas T. Hills, and Trevor W. Robbins (Eds.), Cognitive Search: Evolution, Algorithms, and the Brain, (pp. 97-110). Cambridge: The MIT Press.
  • Winstanley, C., Robbins, T., Balleine, B., Brown, J., Buchel, C., Cools, R., Durstewitz, D., O'Doherty, J., Pennartz, C., Redish, A., et al (2012). Search, goals and the brain. In Peter M. Todd, Thomas T. Hills, and Trevor W. Robbins (Eds.), Cognitive Search: Evolution, Algorithms, and the Brain, (pp. 125-156). Cambridge: The MIT Press.
  • Balleine, B. (2011). Sensation, incentive learning, and the motivational control of goal-directed action. In Jay A Gottfried (Eds.), Neurobiology of Sensation and Reward, (pp. 287-309). Boca Raton: CRC Press.
  • Dickinson, A., Balleine, B. (2009). Hedonics: The cognitive-motivational interface. In Morton L. Kringelbach, Kent C. Berridge (Eds.), Pleasures of the Brain, (pp. 74-84). United States of America: Oxford University Press.
  • Ostlund, S., Winterbauer, N., Balleine, B. (2009). Theory of reward systems. In John Byrne (Eds.), Concise Learning and Memory: The Editor's Selection, (pp. 483-502). United States of America: Elsevier Ltd.
  • Balleine, B., Daw, N., O'Doherty, J. (2008). Multiple forms of value learning and the function of dopamine. Neuroeconomics, (pp. 367-387). United Kingdom: Academic Press Elsevier.
  • Balleine, B. (2008). Taste, disgust and value: taste aversion learning and outcome encoding in instrumental conditioning. In Reilly, Steve; Schachtman, Todd R (Eds.), Conditioned taste aversion: Behavioral and neural processes, (pp. 262-280). New York, USA: Oxford University Press.
  • Balleine, B., Ostlund, S., Winterbauer, N. (2008). Theory of Reward Systems. In R. Menzel (Eds.), Learning Theory and Behavior. Learning and Memory: A Comprehensive Reference (vol 1.), (pp. 701-720). United Kingdom: Elsevier.

Journals

  • Furlong, T., Jayaweera, H., Balleine, B., Corbit, L. (2014). Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum. The Journal of Neuroscience, 34(14), 5012-5022. [More Information]
  • Hart, G., Leung, B., Balleine, B. (2014). Dorsal and ventral streams: The distinct role of striatal subregions in the acquisition and performance of goal-directed actions. Neurobiology of Learning and Memory, 108, 104-118. [More Information]
  • Corbit, L., Chieng, B., Balleine, B. (2014). Effects of Repeated Cocaine Exposure on Habit Learning and Reversal by N-Acetylcysteine. Neuropsychopharmacology, 39(8), 1893-1901. [More Information]
  • Alvares, G., Balleine, B., Guastella, A. (2014). Impairments in goal-directed actions predict treatment response to cognitive-behavioral therapy in social anxiety disorder. PLoS One, 9(4), 1-7. [More Information]
  • Griffiths, K., Morris, R., Balleine, B. (2014). Translational studies of goal-directed action as a framework for classifying deficits across psychiatric disorders. Frontiers in Systems Neuroscience, 8, 1-16. [More Information]
  • Laurent, V., Bertran-Gonzalez, J., Chieng, B., Balleine, B. (2014). δ-opioid and dopaminergic processes in accumbens shell modulate the cholinergic control of predictive learning and choice. The Journal of Neuroscience, 34(4), 1358-1369. [More Information]
  • Dezfouli, A., Balleine, B. (2013). Actions, Action Sequences and Habits: Evidence That Goal-Directed and Habitual Action Control Are Hierarchically Organized. PLoS Computational Biology, 9(12), 1-14. [More Information]
  • Hogarth, L., Balleine, B., Corbit, L., Killcross, S. (2013). Associative learning mechanisms underpinning the transition from recreational drug use to addiction. Annals of the New York Academy of Sciences, 1282 (1), 12-24. [More Information]
  • Bradfield, L., Balleine, B. (2013). Hierarchical and binary associations compete for behavioral control during instrumental biconditional discrimination. Journal of Experimental Psychology, 39(1), 2-13. [More Information]
  • Parkes, S., Balleine, B. (2013). Incentive Memory: Evidence the Basolateral Amygdala Encodes and the Insular Cortex Retrieves Outcome Values to Guide Choice between Goal-Directed Actions. The Journal of Neuroscience, 33(20), 8753-8763. [More Information]
  • Bertran-Gonzalez, J., Laurent, V., Chieng, B., Christie, M., Balleine, B. (2013). Learning-related translocation of δ-Opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions. The Journal of Neuroscience, 33(41), 16060-16071. [More Information]
  • Alvares, G., Quintana, D., Kemp, A., van Zwieten, A., Balleine, B., Hickie, I., Guastella, A. (2013). Reduced heart rate variability in social anxiety disorder: associations with gender and symptom severity. PLoS One, 8(7), 1-8. [More Information]
  • Corbit, L., Leung, B., Balleine, B. (2013). The Role of the Amygdala-Striatal Pathway in the Acquisition and Performance of Goal-Directed Instrumental Actions. The Journal of Neuroscience, 33(45), 17682-17690. [More Information]
  • Bradfield, L., Hart, G., Balleine, B. (2013). The role of the anterior, mediodorsal, and parafascicular thalamus in instrumental conditioning. Frontiers in Systems Neuroscience, 7, 1-15. [More Information]
  • Bradfield, L., Bertran-Gonzalez, J., Chieng, B., Balleine, B. (2013). The Thalamostriatal Pathway and Cholinergic Control of Goal-Directed Action: Interlacing New with Existing Learning in the Striatum. Neuron, 79(1), 153-166. [More Information]
  • Leung, B., Balleine, B. (2013). The ventral striato-pallidal pathway mediates the effect of predictive learning on choice between goal-directed actions. The Journal of Neuroscience, 33(34), 13848-13860. [More Information]
  • Lingawi, N., Balleine, B. (2012). Amygdala central nucleus interacts with dorsolateral striatum to regulate the acquisition of habits. The Journal of Neuroscience, 32(3), 1073-1081. [More Information]
  • Dezfouli, A., Balleine, B. (2012). Habits, action sequences and reinforcement learning. European Journal of Neuroscience, 35(7), 1036-1051. [More Information]
  • Laurent, V., Leung, B., Maidment, N., Balleine, B. (2012). Mu- and delta-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice. The Journal of Neuroscience, 32(5), 1875-1883. [More Information]
  • Alvares, G., Chen, N., Balleine, B., Hickie, I., Guastella, A. (2012). Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males. Psychoneuroendocrinology, 37(12), 2022-2031. [More Information]
  • Bertran-Gonzalez, J., Chieng, B., Laurent, V., Valjent, E., Balleine, B. (2012). Striatal Cholinergic Interneurons Display Activity-Related Phosphorylation of Ribosomal Protein S6. PLoS One, 7(12), 1-11. [More Information]
  • Wassum, K., Tolosa, V., Tseng, T., Balleine, B., Monbouquette, H., Maidment, N. (2012). Transient extracellular glutamate events in the basolateral amygdala track reward-seeking actions. The Journal of Neuroscience, 32(8), 2734-2746. [More Information]
  • Shiflett, M., Balleine, B. (2011). Contributions of ERK signaling in the striatum to instrumental learning and performance. Behavioural Brain Research, 218(1), 240-247. [More Information]
  • Wassum, K., Ostlund, S., Balleine, B., Maidment, N. (2011). Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling. Learning & Memory, 18(7), 475-483. [More Information]
  • Ostlund, S., Wassum, K., Murphy, N., Balleine, B., Maidment, N. (2011). Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning. The Journal of Neuroscience, 31(1), 200-207. [More Information]
  • Wassum, K., Cely, I., Balleine, B., Maidment, N. (2011). Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward. The Journal of Neuroscience, 31(5), 1591-1599. [More Information]
  • Shiflett, M., Balleine, B. (2011). Molecular substrates of action control in cortico-striatal circuits. Progress in Neurobiology, 95(1), 1-13. [More Information]
  • Liljeholm, M., Tricomi, E., O’Doherty, J., Balleine, B. (2011). Neural correlates of instrumental contingency learning: differential effects of action-reward conjunction and disjunction. The Journal of Neuroscience, 31(7), 2474-2480. [More Information]
  • Corbit, L., Balleine, B. (2011). The general and outcome-specific forms of pavlovian-instrumental transfer are differentially mediated by the nucleus accumbens core and shell. The Journal of Neuroscience, 31(33), 11786-11794. [More Information]
  • Balleine, B., Leung, B., Ostlund, S. (2011). The orbitofrontal cortex, predicted value, and choice. Annals of the New York Academy of Sciences, 1239 (1), 43-50. [More Information]
  • Shiflett, M., Brown, R., Balleine, B. (2010). Acquisition and performance of goal-directed instrumental actions depends on ERK signaling in distinct regions of dorsal striatum in rats. The Journal of Neuroscience, 30(8), 2951-2959. [More Information]
  • Ostlund, S., Maidment, N., Balleine, B. (2010). Alcohol-Paired Contextual Cues Produce an Immediate and Selective Loss of Goal-directed Action in Rats. Frontiers in integrative neuroscience, 4(19), 1-8. [More Information]
  • Shiflett, M., Balleine, B. (2010). At the limbic-motor interface: disconnection of basolateral amygdala from nucleus accumbens core and shell reveals dissociable components of incentive motivation. European Journal of Neuroscience, 32(10), 1735-1743. [More Information]
  • Liljeholm, M., Balleine, B. (2010). Extracting functional equivalence from reversing contingencies. Journal of Experimental Psychology: Animal Behavior Processes, 36(2), 165-171. [More Information]
  • Balleine, B., O’Doherty, J. (2010). Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action. Neuropsychopharmacology, 35(1), 48-69. [More Information]
  • Tricomi, E., Balleine, B., O’Doherty, J. (2009). A specific role for posterior dorsolateral striatum in human habit learning. European Journal of Neuroscience, 29(11), 2225-2232. [More Information]
  • Wassum, K., Cely, I., Maidment, N., Balleine, B. (2009). Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition. Neuroscience, 163(3), 770-780. [More Information]
  • Wassum, K., Ostlund, S., Maidment, N., Balleine, B. (2009). Distinct opioid circuits determine the palatability and the desirability of rewarding events. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 106(30), 12512-12517. [More Information]
  • Ostlund, S., Winterbauer, N., Balleine, B. (2009). Evidence of Action Sequence Chunking in Goal-Directed Instrumental Conditioning and Its Dependence on the Dorsomedial Prefrontal Cortex. The Journal of Neuroscience, 29(25), 8280-8287. [More Information]
  • Liljeholm, M., Balleine, B. (2009). Mediated conditioning versus retrospective revaluation in humans: the influence of physical and functional similarity of cues. The Quarterly Journal of Experimental Psychology, 62(3), 470-482. [More Information]
  • de Wit, S., Ostlund, S., Balleine, B., Dickinson, A. (2009). Resolution of conflict between goal-directed actions: Outcome encoding and neural control processes. Journal of Experimental Psychology: Animal Behavior Processes, 35(3), 382-393. [More Information]
  • Balleine, B., Liljeholm, M., Ostlund, S. (2009). The integrative function of the basal ganglia in instrumental conditioning. Behavioural Brain Research, 199(1), 43-52. [More Information]
  • Tanaka, S., Balleine, B., O’Doherty, J. (2008). Calculating consequences: brain systems that encode the causal effects of actions. The Journal of Neuroscience, 28(26), 6750-6755. [More Information]
  • Ostlund, S., Balleine, B. (2008). Differential involvement of the basolateral amygdala and mediodorsal thalamus in instrumental action selection. The Journal of Neuroscience, 28(17), 4398-4405. [More Information]
  • Espinet, A., Artigas, A., Balleine, B. (2008). Inhibitory sensory preconditioning detected with a sodium depletion procedure. The Quarterly Journal of Experimental Psychology, 61(2), 240-247. [More Information]
  • Ostlund, S., Balleine, B. (2008). On habits and addiction: An associative analysis of compulsive drug seeking. Drug Discovery Today: Disease Models, 5(4), 235-245. [More Information]
  • Yin, H., Ostlund, S., Balleine, B. (2008). Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. European Journal of Neuroscience, 28(8), 1437-1448. [More Information]
  • Ostlund, S., Balleine, B. (2008). The disunity of Pavlovian and instrumental values. Behavioral and Brain Sciences, 31, 456-457.
  • Bray, S., Rangel, A., Shimojo, S., Balleine, B., O’Doherty, J. (2008). The Neural Mechanisms Underlying the Influence of Pavlovian Cues on Human Decision Making. The Journal of Neuroscience, 28(22), 5861-5866. [More Information]
  • Nader, K., Balleine, B. (2007). Ambiguity and anxiety: when a glass half full is empty. Nature Neuroscience, 10(7), 807-808. [More Information]
  • Balleine, B., Doya, K., O'Doherty, J., Sakagami, M. (2007). Current trends in decision making. Annals of the New York Academy of Sciences, 1104, xi-xv. [More Information]
  • Corbit, L., Janak, P., Balleine, B. (2007). General and outcome-specific forms of Pavlovian-instrumental transfer: the effect of shifts in motivational state and inactivation of the ventral tegmental area. European Journal of Neuroscience, 26(11), 3141-3149. [More Information]
  • Lobo, M., Cui, Y., Ostlund, S., Balleine, B., Yang, X. (2007). Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6. Nature Neuroscience, 10(11), 1395-1397. [More Information]
  • Ostlund, S., Balleine, B. (2007). Orbitofrontal Cortex Mediates Outcome Encoding in Pavlovian But Not Instrumental Conditioning. The Journal of Neuroscience, 27(18), 4819-4825. [More Information]
  • Ostlund, S., Balleine, B. (2007). Selective reinstatement of instrumental performance depends on the discriminative stimulus properties of the mediating outcome. Learning and Behavior (Print Edition), 35(1), 43-52. [More Information]
  • Balleine, B., Ostlund, S. (2007). Still at the choice-point: action selection and initiation in instrumental conditioning. Annals of the New York Academy of Sciences, 1104, 147-171. [More Information]
  • Ostlund, S., Balleine, B. (2007). The contribution of orbitofrontal cortex to action selection. Annals of the New York Academy of Sciences, 1121, 174-192. [More Information]
  • Winterbauer, N., Balleine, B. (2007). The influence of amphetamine on sensory and conditioned reinforcement: evidence for the re-selection hypothesis of dopamine function. Frontiers in integrative neuroscience, 1, 1-8. [More Information]
  • Wiltgen, B., Law, M., Ostlund, S., Mayford, M., Balleine, B. (2007). The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. European Journal of Neuroscience, 25(8), 2491-2497. [More Information]
  • Balleine, B. (2007). The neural basis of choice and decision-making. The Journal of Neuroscience, 27, 8159-8160.
  • Balleine, B., Delgado, M., Hikosaka, O. (2007). The role of the dorsal striatum in reward and decision-making. The Journal of Neuroscience, 27(31), 8161-8165. [More Information]
  • de Wit, S., Kosaki, Y., Balleine, B., Dickinson, A. (2006). Dorsomedial Prefrontal Cortex Resolves Response Conflict in Rats. The Journal of Neuroscience, 26(19), 5224-5229. [More Information]
  • Yin, H., Knowlton, B., Balleine, B. (2006). Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning. Behavioural Brain Research, 166(2), 189-196. [More Information]
  • Yin, H., Zhuang, X., Balleine, B. (2006). Instrumental learning in hyperdopaminergic mice. Neurobiology of Learning and Memory, 85(3), 283-288. [More Information]
  • Balleine, B., Dickinson, A. (2006). Motivational control of blocking. Journal of Experimental Psychology: Animal Behavior Processes, 32(1), 33-43. [More Information]
  • Balleine, B., Killcross, S. (2006). Parallel incentive processing: an integrated view of amygdala function. Trends in Neurosciences, 29(5), 272-279. [More Information]
  • Liljeholm, M., Balleine, B. (2006). Stimulus salience and retrospective revaluation. Journal of Experimental Psychology: Animal Behavior Processes, 32(4), 481-487. [More Information]
  • Yin, H., Knowlton, B., Balleine, B. (2005). Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioning. European Journal of Neuroscience, 22(2), 505-512. [More Information]
  • Wang, S., Ostlund, S., Nader, K., Balleine, B. (2005). Consolidation and Reconsolidation of Incentive Learning in the Amygdala. The Journal of Neuroscience, 25(4), 830-835. [More Information]
  • Corbit, L., Balleine, B. (2005). Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer. The Journal of Neuroscience, 25(4), 962-970. [More Information]
  • Ostlund, S., Balleine, B. (2005). Lesions of Medial Prefrontal Cortex Disrupt the Acquisition But Not the Expression of Goal-Directed Learning. The Journal of Neuroscience, 25(34), 7763-7770. [More Information]
  • Winterbauer, N., Balleine, B. (2005). Motivational Control of Second-Order Conditioning. Journal of Experimental Psychology: Animal Behavior Processes, 31(3), 334-340. [More Information]
  • Balleine, B. (2005). Neural bases of food-seeking: affect, arousal and reward in corticostriatolimbic circuits. Physiology and Behavior, 86(5), 717-730. [More Information]
  • Balleine, B., Espinet, A., Gonzalez, F. (2005). Perceptual Learning Enhances Retrospective Revaluation of Conditioned Flavor Preferences in Rats. Journal of Experimental Psychology: Animal Behavior Processes, 31(3), 341. [More Information]
  • Balleine, B., Paredes-Olay, C., Dickinson, A. (2005). The effect of outcome devaluation on the performance of a heterogenous instrumental chain. International Journal of Comparative Psychology, 18(4), 257-272.
  • Glasner, S., Overmier, J., Balleine, B. (2005). The role of Pavlovian cues in alcohol seeking in dependent and nondependent rats. Journal of Studies on Alcohol, 66(1), 53-61.
  • Yin, H., Ostlund, S., Knowlton, B., Balleine, B. (2005). The role of the dorsomedial striatum in instrumental conditioning. European Journal of Neuroscience, 22(2), 513-523. [More Information]
  • Espinet, A., Gonzalez, F., Balleine, B. (2004). Inhibitory sensory preconditioning. The Quarterly Journal of Experimental Psychology, 57B(3), 261-272. [More Information]
  • Yin, H., Knowlton, B., Balleine, B. (2004). Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning. European Journal of Neuroscience, 19(1), 181-189. [More Information]
  • Frankland, P., Wang, Y., Rosner, B., Shimizu, T., Balleine, B., Dykens, E., Ornitz, E., Silva, A. (2004). Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice. Molecular Psychiatry, 9(4), 417-425. [More Information]
  • Hunter, A., Balleine, B., Minor, T. (2003). Helplessness and escape performance: glutamate-adenosine interactions in the frontal cortex. Behavioral Neuroscience, 117(1), 123-135. [More Information]
  • Corbit, L., Balleine, B. (2003). Instrumental and Pavlovian incentive processes have dissociable effects on components of a heterogeneous instrumental chain. Journal of Experimental Psychology: Animal Behavior Processes, 29(2), 99-106. [More Information]
  • Corbit, L., Muir, J., Balleine, B. (2003). Lesions of mediodorsal thalamus and anterior thalamic nuclei produce dissociable effects on instrumental conditioning in rats. European Journal of Neuroscience, 18(5), 1286-1294. [More Information]
  • Balleine, B., Killcross, A., Dickinson, A. (2003). The Effect of Lesions of the Basolateral Amygdala on Instrumental Conditioning. The Journal of Neuroscience, 23(2), 666-675. [More Information]
  • Saade, S., Balleine, B., Minor, T. (2003). The L-type calcium channel blocker nimodipine mitigates "learned helplessness" in rats. Pharmacology, Biochemistry and Behavior, 74(2), 269-278. [More Information]
  • Corbit, L., Balleine, B. (2003). The role of prelimbic cortex in instrumental conditioning. Behavioural Brain Research, 146(1-2), 145-157. [More Information]

Conferences

  • Hart, G., Angelis, G., Kyme, A., Ryder, W., Meikle, S., Fulton, R., Parmar, A., Balleine, B. (2013). MicroPET assessment of regional brain activation during pavlovian learning in conscious unrestrained rats. World Molecular Imaging Congress 2013, Georgia, USA.

2014

  • Furlong, T., Jayaweera, H., Balleine, B., Corbit, L. (2014). Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum. The Journal of Neuroscience, 34(14), 5012-5022. [More Information]
  • Hart, G., Leung, B., Balleine, B. (2014). Dorsal and ventral streams: The distinct role of striatal subregions in the acquisition and performance of goal-directed actions. Neurobiology of Learning and Memory, 108, 104-118. [More Information]
  • Corbit, L., Chieng, B., Balleine, B. (2014). Effects of Repeated Cocaine Exposure on Habit Learning and Reversal by N-Acetylcysteine. Neuropsychopharmacology, 39(8), 1893-1901. [More Information]
  • Alvares, G., Balleine, B., Guastella, A. (2014). Impairments in goal-directed actions predict treatment response to cognitive-behavioral therapy in social anxiety disorder. PLoS One, 9(4), 1-7. [More Information]
  • Griffiths, K., Morris, R., Balleine, B. (2014). Translational studies of goal-directed action as a framework for classifying deficits across psychiatric disorders. Frontiers in Systems Neuroscience, 8, 1-16. [More Information]
  • Laurent, V., Bertran-Gonzalez, J., Chieng, B., Balleine, B. (2014). δ-opioid and dopaminergic processes in accumbens shell modulate the cholinergic control of predictive learning and choice. The Journal of Neuroscience, 34(4), 1358-1369. [More Information]

2013

  • Dezfouli, A., Balleine, B. (2013). Actions, Action Sequences and Habits: Evidence That Goal-Directed and Habitual Action Control Are Hierarchically Organized. PLoS Computational Biology, 9(12), 1-14. [More Information]
  • Hogarth, L., Balleine, B., Corbit, L., Killcross, S. (2013). Associative learning mechanisms underpinning the transition from recreational drug use to addiction. Annals of the New York Academy of Sciences, 1282 (1), 12-24. [More Information]
  • Bradfield, L., Balleine, B. (2013). Hierarchical and binary associations compete for behavioral control during instrumental biconditional discrimination. Journal of Experimental Psychology, 39(1), 2-13. [More Information]
  • Parkes, S., Balleine, B. (2013). Incentive Memory: Evidence the Basolateral Amygdala Encodes and the Insular Cortex Retrieves Outcome Values to Guide Choice between Goal-Directed Actions. The Journal of Neuroscience, 33(20), 8753-8763. [More Information]
  • Bertran-Gonzalez, J., Laurent, V., Chieng, B., Christie, M., Balleine, B. (2013). Learning-related translocation of δ-Opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions. The Journal of Neuroscience, 33(41), 16060-16071. [More Information]
  • Hart, G., Angelis, G., Kyme, A., Ryder, W., Meikle, S., Fulton, R., Parmar, A., Balleine, B. (2013). MicroPET assessment of regional brain activation during pavlovian learning in conscious unrestrained rats. World Molecular Imaging Congress 2013, Georgia, USA.
  • Alvares, G., Quintana, D., Kemp, A., van Zwieten, A., Balleine, B., Hickie, I., Guastella, A. (2013). Reduced heart rate variability in social anxiety disorder: associations with gender and symptom severity. PLoS One, 8(7), 1-8. [More Information]
  • Corbit, L., Leung, B., Balleine, B. (2013). The Role of the Amygdala-Striatal Pathway in the Acquisition and Performance of Goal-Directed Instrumental Actions. The Journal of Neuroscience, 33(45), 17682-17690. [More Information]
  • Bradfield, L., Hart, G., Balleine, B. (2013). The role of the anterior, mediodorsal, and parafascicular thalamus in instrumental conditioning. Frontiers in Systems Neuroscience, 7, 1-15. [More Information]
  • Bradfield, L., Bertran-Gonzalez, J., Chieng, B., Balleine, B. (2013). The Thalamostriatal Pathway and Cholinergic Control of Goal-Directed Action: Interlacing New with Existing Learning in the Striatum. Neuron, 79(1), 153-166. [More Information]
  • Leung, B., Balleine, B. (2013). The ventral striato-pallidal pathway mediates the effect of predictive learning on choice between goal-directed actions. The Journal of Neuroscience, 33(34), 13848-13860. [More Information]

2012

  • Lingawi, N., Balleine, B. (2012). Amygdala central nucleus interacts with dorsolateral striatum to regulate the acquisition of habits. The Journal of Neuroscience, 32(3), 1073-1081. [More Information]
  • Dezfouli, A., Balleine, B. (2012). Habits, action sequences and reinforcement learning. European Journal of Neuroscience, 35(7), 1036-1051. [More Information]
  • Laurent, V., Leung, B., Maidment, N., Balleine, B. (2012). Mu- and delta-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice. The Journal of Neuroscience, 32(5), 1875-1883. [More Information]
  • O'Doherty, J., Balleine, B. (2012). Neural bases of actions and habits. In Peter M. Todd, Thomas T. Hills, and Trevor W. Robbins (Eds.), Cognitive Search: Evolution, Algorithms, and the Brain, (pp. 97-110). Cambridge: The MIT Press.
  • Alvares, G., Chen, N., Balleine, B., Hickie, I., Guastella, A. (2012). Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males. Psychoneuroendocrinology, 37(12), 2022-2031. [More Information]
  • Winstanley, C., Robbins, T., Balleine, B., Brown, J., Buchel, C., Cools, R., Durstewitz, D., O'Doherty, J., Pennartz, C., Redish, A., et al (2012). Search, goals and the brain. In Peter M. Todd, Thomas T. Hills, and Trevor W. Robbins (Eds.), Cognitive Search: Evolution, Algorithms, and the Brain, (pp. 125-156). Cambridge: The MIT Press.
  • Bertran-Gonzalez, J., Chieng, B., Laurent, V., Valjent, E., Balleine, B. (2012). Striatal Cholinergic Interneurons Display Activity-Related Phosphorylation of Ribosomal Protein S6. PLoS One, 7(12), 1-11. [More Information]
  • Wassum, K., Tolosa, V., Tseng, T., Balleine, B., Monbouquette, H., Maidment, N. (2012). Transient extracellular glutamate events in the basolateral amygdala track reward-seeking actions. The Journal of Neuroscience, 32(8), 2734-2746. [More Information]

2011

  • Shiflett, M., Balleine, B. (2011). Contributions of ERK signaling in the striatum to instrumental learning and performance. Behavioural Brain Research, 218(1), 240-247. [More Information]
  • Wassum, K., Ostlund, S., Balleine, B., Maidment, N. (2011). Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling. Learning & Memory, 18(7), 475-483. [More Information]
  • Ostlund, S., Wassum, K., Murphy, N., Balleine, B., Maidment, N. (2011). Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning. The Journal of Neuroscience, 31(1), 200-207. [More Information]
  • Wassum, K., Cely, I., Balleine, B., Maidment, N. (2011). Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward. The Journal of Neuroscience, 31(5), 1591-1599. [More Information]
  • Shiflett, M., Balleine, B. (2011). Molecular substrates of action control in cortico-striatal circuits. Progress in Neurobiology, 95(1), 1-13. [More Information]
  • Liljeholm, M., Tricomi, E., O’Doherty, J., Balleine, B. (2011). Neural correlates of instrumental contingency learning: differential effects of action-reward conjunction and disjunction. The Journal of Neuroscience, 31(7), 2474-2480. [More Information]
  • Balleine, B. (2011). Sensation, incentive learning, and the motivational control of goal-directed action. In Jay A Gottfried (Eds.), Neurobiology of Sensation and Reward, (pp. 287-309). Boca Raton: CRC Press.
  • Corbit, L., Balleine, B. (2011). The general and outcome-specific forms of pavlovian-instrumental transfer are differentially mediated by the nucleus accumbens core and shell. The Journal of Neuroscience, 31(33), 11786-11794. [More Information]
  • Balleine, B., Leung, B., Ostlund, S. (2011). The orbitofrontal cortex, predicted value, and choice. Annals of the New York Academy of Sciences, 1239 (1), 43-50. [More Information]

2010

  • Shiflett, M., Brown, R., Balleine, B. (2010). Acquisition and performance of goal-directed instrumental actions depends on ERK signaling in distinct regions of dorsal striatum in rats. The Journal of Neuroscience, 30(8), 2951-2959. [More Information]
  • Ostlund, S., Maidment, N., Balleine, B. (2010). Alcohol-Paired Contextual Cues Produce an Immediate and Selective Loss of Goal-directed Action in Rats. Frontiers in integrative neuroscience, 4(19), 1-8. [More Information]
  • Shiflett, M., Balleine, B. (2010). At the limbic-motor interface: disconnection of basolateral amygdala from nucleus accumbens core and shell reveals dissociable components of incentive motivation. European Journal of Neuroscience, 32(10), 1735-1743. [More Information]
  • Liljeholm, M., Balleine, B. (2010). Extracting functional equivalence from reversing contingencies. Journal of Experimental Psychology: Animal Behavior Processes, 36(2), 165-171. [More Information]
  • Balleine, B., O’Doherty, J. (2010). Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action. Neuropsychopharmacology, 35(1), 48-69. [More Information]

2009

  • Tricomi, E., Balleine, B., O’Doherty, J. (2009). A specific role for posterior dorsolateral striatum in human habit learning. European Journal of Neuroscience, 29(11), 2225-2232. [More Information]
  • Wassum, K., Cely, I., Maidment, N., Balleine, B. (2009). Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition. Neuroscience, 163(3), 770-780. [More Information]
  • Wassum, K., Ostlund, S., Maidment, N., Balleine, B. (2009). Distinct opioid circuits determine the palatability and the desirability of rewarding events. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 106(30), 12512-12517. [More Information]
  • Ostlund, S., Winterbauer, N., Balleine, B. (2009). Evidence of Action Sequence Chunking in Goal-Directed Instrumental Conditioning and Its Dependence on the Dorsomedial Prefrontal Cortex. The Journal of Neuroscience, 29(25), 8280-8287. [More Information]
  • Dickinson, A., Balleine, B. (2009). Hedonics: The cognitive-motivational interface. In Morton L. Kringelbach, Kent C. Berridge (Eds.), Pleasures of the Brain, (pp. 74-84). United States of America: Oxford University Press.
  • Liljeholm, M., Balleine, B. (2009). Mediated conditioning versus retrospective revaluation in humans: the influence of physical and functional similarity of cues. The Quarterly Journal of Experimental Psychology, 62(3), 470-482. [More Information]
  • de Wit, S., Ostlund, S., Balleine, B., Dickinson, A. (2009). Resolution of conflict between goal-directed actions: Outcome encoding and neural control processes. Journal of Experimental Psychology: Animal Behavior Processes, 35(3), 382-393. [More Information]
  • Balleine, B., Liljeholm, M., Ostlund, S. (2009). The integrative function of the basal ganglia in instrumental conditioning. Behavioural Brain Research, 199(1), 43-52. [More Information]
  • Ostlund, S., Winterbauer, N., Balleine, B. (2009). Theory of reward systems. In John Byrne (Eds.), Concise Learning and Memory: The Editor's Selection, (pp. 483-502). United States of America: Elsevier Ltd.

2008

  • Tanaka, S., Balleine, B., O’Doherty, J. (2008). Calculating consequences: brain systems that encode the causal effects of actions. The Journal of Neuroscience, 28(26), 6750-6755. [More Information]
  • Ostlund, S., Balleine, B. (2008). Differential involvement of the basolateral amygdala and mediodorsal thalamus in instrumental action selection. The Journal of Neuroscience, 28(17), 4398-4405. [More Information]
  • Espinet, A., Artigas, A., Balleine, B. (2008). Inhibitory sensory preconditioning detected with a sodium depletion procedure. The Quarterly Journal of Experimental Psychology, 61(2), 240-247. [More Information]
  • Balleine, B., Daw, N., O'Doherty, J. (2008). Multiple forms of value learning and the function of dopamine. Neuroeconomics, (pp. 367-387). United Kingdom: Academic Press Elsevier.
  • Ostlund, S., Balleine, B. (2008). On habits and addiction: An associative analysis of compulsive drug seeking. Drug Discovery Today: Disease Models, 5(4), 235-245. [More Information]
  • Yin, H., Ostlund, S., Balleine, B. (2008). Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. European Journal of Neuroscience, 28(8), 1437-1448. [More Information]
  • Balleine, B. (2008). Taste, disgust and value: taste aversion learning and outcome encoding in instrumental conditioning. In Reilly, Steve; Schachtman, Todd R (Eds.), Conditioned taste aversion: Behavioral and neural processes, (pp. 262-280). New York, USA: Oxford University Press.
  • Ostlund, S., Balleine, B. (2008). The disunity of Pavlovian and instrumental values. Behavioral and Brain Sciences, 31, 456-457.
  • Bray, S., Rangel, A., Shimojo, S., Balleine, B., O’Doherty, J. (2008). The Neural Mechanisms Underlying the Influence of Pavlovian Cues on Human Decision Making. The Journal of Neuroscience, 28(22), 5861-5866. [More Information]
  • Balleine, B., Ostlund, S., Winterbauer, N. (2008). Theory of Reward Systems. In R. Menzel (Eds.), Learning Theory and Behavior. Learning and Memory: A Comprehensive Reference (vol 1.), (pp. 701-720). United Kingdom: Elsevier.

2007

  • Nader, K., Balleine, B. (2007). Ambiguity and anxiety: when a glass half full is empty. Nature Neuroscience, 10(7), 807-808. [More Information]
  • Balleine, B., Doya, K., O'Doherty, J., Sakagami, M. (2007). Current trends in decision making. Annals of the New York Academy of Sciences, 1104, xi-xv. [More Information]
  • Corbit, L., Janak, P., Balleine, B. (2007). General and outcome-specific forms of Pavlovian-instrumental transfer: the effect of shifts in motivational state and inactivation of the ventral tegmental area. European Journal of Neuroscience, 26(11), 3141-3149. [More Information]
  • Lobo, M., Cui, Y., Ostlund, S., Balleine, B., Yang, X. (2007). Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6. Nature Neuroscience, 10(11), 1395-1397. [More Information]
  • Ostlund, S., Balleine, B. (2007). Orbitofrontal Cortex Mediates Outcome Encoding in Pavlovian But Not Instrumental Conditioning. The Journal of Neuroscience, 27(18), 4819-4825. [More Information]
  • Ostlund, S., Balleine, B. (2007). Selective reinstatement of instrumental performance depends on the discriminative stimulus properties of the mediating outcome. Learning and Behavior (Print Edition), 35(1), 43-52. [More Information]
  • Balleine, B., Ostlund, S. (2007). Still at the choice-point: action selection and initiation in instrumental conditioning. Annals of the New York Academy of Sciences, 1104, 147-171. [More Information]
  • Ostlund, S., Balleine, B. (2007). The contribution of orbitofrontal cortex to action selection. Annals of the New York Academy of Sciences, 1121, 174-192. [More Information]
  • Winterbauer, N., Balleine, B. (2007). The influence of amphetamine on sensory and conditioned reinforcement: evidence for the re-selection hypothesis of dopamine function. Frontiers in integrative neuroscience, 1, 1-8. [More Information]
  • Wiltgen, B., Law, M., Ostlund, S., Mayford, M., Balleine, B. (2007). The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. European Journal of Neuroscience, 25(8), 2491-2497. [More Information]
  • Balleine, B. (2007). The neural basis of choice and decision-making. The Journal of Neuroscience, 27, 8159-8160.
  • Balleine, B., Delgado, M., Hikosaka, O. (2007). The role of the dorsal striatum in reward and decision-making. The Journal of Neuroscience, 27(31), 8161-8165. [More Information]

2006

  • de Wit, S., Kosaki, Y., Balleine, B., Dickinson, A. (2006). Dorsomedial Prefrontal Cortex Resolves Response Conflict in Rats. The Journal of Neuroscience, 26(19), 5224-5229. [More Information]
  • Yin, H., Knowlton, B., Balleine, B. (2006). Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning. Behavioural Brain Research, 166(2), 189-196. [More Information]
  • Yin, H., Zhuang, X., Balleine, B. (2006). Instrumental learning in hyperdopaminergic mice. Neurobiology of Learning and Memory, 85(3), 283-288. [More Information]
  • Balleine, B., Dickinson, A. (2006). Motivational control of blocking. Journal of Experimental Psychology: Animal Behavior Processes, 32(1), 33-43. [More Information]
  • Balleine, B., Killcross, S. (2006). Parallel incentive processing: an integrated view of amygdala function. Trends in Neurosciences, 29(5), 272-279. [More Information]
  • Liljeholm, M., Balleine, B. (2006). Stimulus salience and retrospective revaluation. Journal of Experimental Psychology: Animal Behavior Processes, 32(4), 481-487. [More Information]

2005

  • Yin, H., Knowlton, B., Balleine, B. (2005). Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioning. European Journal of Neuroscience, 22(2), 505-512. [More Information]
  • Wang, S., Ostlund, S., Nader, K., Balleine, B. (2005). Consolidation and Reconsolidation of Incentive Learning in the Amygdala. The Journal of Neuroscience, 25(4), 830-835. [More Information]
  • Corbit, L., Balleine, B. (2005). Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer. The Journal of Neuroscience, 25(4), 962-970. [More Information]
  • Ostlund, S., Balleine, B. (2005). Lesions of Medial Prefrontal Cortex Disrupt the Acquisition But Not the Expression of Goal-Directed Learning. The Journal of Neuroscience, 25(34), 7763-7770. [More Information]
  • Winterbauer, N., Balleine, B. (2005). Motivational Control of Second-Order Conditioning. Journal of Experimental Psychology: Animal Behavior Processes, 31(3), 334-340. [More Information]
  • Balleine, B. (2005). Neural bases of food-seeking: affect, arousal and reward in corticostriatolimbic circuits. Physiology and Behavior, 86(5), 717-730. [More Information]
  • Balleine, B., Espinet, A., Gonzalez, F. (2005). Perceptual Learning Enhances Retrospective Revaluation of Conditioned Flavor Preferences in Rats. Journal of Experimental Psychology: Animal Behavior Processes, 31(3), 341. [More Information]
  • Balleine, B., Paredes-Olay, C., Dickinson, A. (2005). The effect of outcome devaluation on the performance of a heterogenous instrumental chain. International Journal of Comparative Psychology, 18(4), 257-272.
  • Glasner, S., Overmier, J., Balleine, B. (2005). The role of Pavlovian cues in alcohol seeking in dependent and nondependent rats. Journal of Studies on Alcohol, 66(1), 53-61.
  • Yin, H., Ostlund, S., Knowlton, B., Balleine, B. (2005). The role of the dorsomedial striatum in instrumental conditioning. European Journal of Neuroscience, 22(2), 513-523. [More Information]

2004

  • Espinet, A., Gonzalez, F., Balleine, B. (2004). Inhibitory sensory preconditioning. The Quarterly Journal of Experimental Psychology, 57B(3), 261-272. [More Information]
  • Yin, H., Knowlton, B., Balleine, B. (2004). Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning. European Journal of Neuroscience, 19(1), 181-189. [More Information]
  • Frankland, P., Wang, Y., Rosner, B., Shimizu, T., Balleine, B., Dykens, E., Ornitz, E., Silva, A. (2004). Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice. Molecular Psychiatry, 9(4), 417-425. [More Information]

2003

  • Hunter, A., Balleine, B., Minor, T. (2003). Helplessness and escape performance: glutamate-adenosine interactions in the frontal cortex. Behavioral Neuroscience, 117(1), 123-135. [More Information]
  • Corbit, L., Balleine, B. (2003). Instrumental and Pavlovian incentive processes have dissociable effects on components of a heterogeneous instrumental chain. Journal of Experimental Psychology: Animal Behavior Processes, 29(2), 99-106. [More Information]
  • Corbit, L., Muir, J., Balleine, B. (2003). Lesions of mediodorsal thalamus and anterior thalamic nuclei produce dissociable effects on instrumental conditioning in rats. European Journal of Neuroscience, 18(5), 1286-1294. [More Information]
  • Balleine, B., Killcross, A., Dickinson, A. (2003). The Effect of Lesions of the Basolateral Amygdala on Instrumental Conditioning. The Journal of Neuroscience, 23(2), 666-675. [More Information]
  • Saade, S., Balleine, B., Minor, T. (2003). The L-type calcium channel blocker nimodipine mitigates "learned helplessness" in rats. Pharmacology, Biochemistry and Behavior, 74(2), 269-278. [More Information]
  • Corbit, L., Balleine, B. (2003). The role of prelimbic cortex in instrumental conditioning. Behavioural Brain Research, 146(1-2), 145-157. [More Information]

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