Professor William Webster

Professor of Reproductive Toxicology
Anatomy & Histology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 2498
Fax +61 2 9351 2813

Map

Selected grants

2014

  • The role of foetal hypoxia and hyperglycaemia in the formation of cleft lip maxillary hypoplasia; Howe A, Ritchie H, Webster W; Australian Dental Research Foundation/Research Support.

2009

  • The role of foetal hypoxia in cleft lip and maxillary hypoplasia; Howe A, Oakes D, Webster W, Ritchie H; Australian Dental Research Foundation/Research Support.
  • Prenatal facial development and the role of oxygen; Oakes D, Ritchie H, Webster W, Howe A; Dental Board of NSW/Research Support.

2005

  • Toxicity screening of chemicals - Grant Shared between Dr Oakes/School Biomedical Science (RC S3401) ;Prof Webster/Anatomy & Histology (RC K0301); Gill C, Horsley K, Webster W, Oakes D; Department of Veterans' Affairs/BLO Project.

2001

  • Potential causal links of chemical exposure and cancer or genentic disorders; Webster W; Comm Dept Vet Affairs/BLO Project.
  • Potential causal links of chemical exposure and cancer or genentic disorders; Horsley K, Webster W; Department of Veterans' Affairs/BLO Project.
  • The pathogenisis of cleft lip and palate in a rat model of the human condition of phenytoin-induced cleft lip and palate.; Webster W; Australian Society of Orthodontists Foundation for Research and Education/Research Grant.
  • The role of fetal hypoxia in maxillary hypoplasia in the rat; Webster W; Dental Board of NSW/Research Grants.

2000

  • Can antioxidants prevent hypoxia-induced facial clefting in the rat?; Webster W; Australian Dental Research Foundation/Research Grants.
  • The role of vitamin K in prenatal development; Webster W, Woodman P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of herbicides and other chemicals in causing male-mediated developmental toxicity; Webster W, Pollak J, Woodman P, Ritchie H; Veterans Affairs/Health and Medical Research Grants.

Selected publications

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Journals

  • Nilsson, M., Webster, W. (2014). Effects of macrolide antibiotics on rat embryonic heart function in vitro. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 101(2), 189-198. [More Information]
  • Nilsson, M., Skold, A., Ericson, A., Annas, A., Villar, R., Cebers, G., Hellmold, H., Gustafson, A., Webster, W. (2013). Comparative effects of sodium channel blockers in short term rat whole embryo culture. Toxicology and Applied Pharmacology, 272(2), 306-312. [More Information]
  • Nilsson, M., Ritchie, H., Webster, W. (2013). The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 98(5), 416-427. [More Information]
  • Ritchie, H., Ababneh, D., Oakes, D., Power, C., Webster, W. (2013). The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 98(2), 144-153. [More Information]
  • Ababneh, D., Ritchie, H., Webster, W. (2012). Antidepressants Cause Bradycardia and Heart Block in GD 13 Rat Embryos In Vitro. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 95(2), 184-193. [More Information]
  • Gunnstrom, M., Ababneh, D., Webster, W., Oakes, D., Ritchie, H. (2012). Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro. Reproductive Toxicology, 34(3), 443-450. [More Information]
  • Nilsson, M., Danielsson, C., Skold, A., Johansson, A., Blomgren, B., Wilson, J., Khan, K., Bengtsson, E., Kultima, K., Webster, W., et al (2010). Improved Methodology for Identifying the Teratogenic Potential in Early Drug Development of hERG Channel Blocking Drugs. Reproductive Toxicology, 29(2), 156-163. [More Information]
  • Abela, D., Ritchie, H., Ababneh, D., Gavin, C., Nilsson, M., Khan, M., Carlsson, K., Webster, W. (2010). The effect of drugs with ion channel-blocking activity on the early embryonic rat heart. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 89(5), 429-440. [More Information]
  • Oakes, D., Ritchie, H., Woodman, P., Narup, E., Moscova, M., Picker, K., Webster, W. (2009). Genotoxicity studies of a desealant solvent mixture, SR-51. Toxicology and Industrial Health: An International Journal, 25(1), 5-13. [More Information]
  • Jones, K., Webster, W., Vaux, K., Benirschke, K. (2008). Acardiac fetus: evidence in support of a vascular/hypoxia pathogenesis for isolated oral clefting. Birth Defects Research. Part A: Clinical and Molecular Teratology, 82(8), 597-600. [More Information]
  • Karlsson, M., Danielsson, B., Nilsson, M., Danielsson, C., Webster, W. (2007). New Proposals for Testing Drugs with IKr-Blocking Activity to Determine Their Teratogenic Potential. Current Pharmaceutical Design, 13(29), 2979-2988. [More Information]
  • Webster, W., Abela, D. (2007). The effect of hypoxia in development. Birth Defects Research. Part C: Embryo Today Reviews, 81(3), 215-228. [More Information]
  • Webster, W., Howe, A., Abela, D., Oakes, D. (2006). The relationship between cleft lip maxillary hypoplasia, hypoxia and phenytoin. Current Pharmaceutical Design, 12(12), 1431-1448. [More Information]
  • Abela, D., Howe, A., Oakes, D., Webster, W. (2005). Maternal antioxidant supplementation does not reduce the incidence of phenytoin-induced cleft lip and related malformations in rats. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 74(2), 201-206. [More Information]
  • Moscova, M., Oakes, D., Pollak, J., Webster, W. (2004). Effects of a desealant formulation, SR-51 and its individual components on the oxidative functions of mitochondria. Environmental Toxicology and Pharmacology, 18(2), 181-184.
  • Howe, A., Hawkins, J., Webster, W. (2004). The Growth Of The Nasal Septum In The 6-9 Week Period Of Foetal Development--Warfarin Embryopathy Offers A New Insight Into Prenatal Facial Development. Australian Dental Journal, 49(4), 171-176.
  • Webster, W., Freeman, J. (2003). Prescription drugs and pregnancy. Expert Opinion on Pharmacotherapy, 4(6), 949-961.
  • Oakes, D., Webster, W., Woodman, P., Ritchie, H. (2002). A Study of the Potential for a Herbicide Formulation Containing 2,4-D and Picloram to Cause Male-Mediated Developmental Toxicity in Rats. Toxicological Sciences, 68(1), 200-206.
  • Oakes, D., Webster, W., Woodman, P., Ritchie, H. (2002). Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D(R) (2,4-dichlorophenoxyacetic acid and picloram)in rats. Reproductive Toxicology, 16(3), 281-289.
  • Webster, W., Freeman, J. (2001). Is this drug safe in pregnancy? Reproductive Toxicology, 15 (6), 619-629.

Conferences

  • Oakes, D., Webster, W., Woodman, P., Ritchie, H. (2001). Male mediated developmental toxicity and the herbicide formulation, Tordon 75D. Australian Birth Defects Society, : World Scientific Publishing.

2014

  • Nilsson, M., Webster, W. (2014). Effects of macrolide antibiotics on rat embryonic heart function in vitro. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 101(2), 189-198. [More Information]

2013

  • Nilsson, M., Skold, A., Ericson, A., Annas, A., Villar, R., Cebers, G., Hellmold, H., Gustafson, A., Webster, W. (2013). Comparative effects of sodium channel blockers in short term rat whole embryo culture. Toxicology and Applied Pharmacology, 272(2), 306-312. [More Information]
  • Nilsson, M., Ritchie, H., Webster, W. (2013). The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 98(5), 416-427. [More Information]
  • Ritchie, H., Ababneh, D., Oakes, D., Power, C., Webster, W. (2013). The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 98(2), 144-153. [More Information]

2012

  • Ababneh, D., Ritchie, H., Webster, W. (2012). Antidepressants Cause Bradycardia and Heart Block in GD 13 Rat Embryos In Vitro. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 95(2), 184-193. [More Information]
  • Gunnstrom, M., Ababneh, D., Webster, W., Oakes, D., Ritchie, H. (2012). Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro. Reproductive Toxicology, 34(3), 443-450. [More Information]

2010

  • Nilsson, M., Danielsson, C., Skold, A., Johansson, A., Blomgren, B., Wilson, J., Khan, K., Bengtsson, E., Kultima, K., Webster, W., et al (2010). Improved Methodology for Identifying the Teratogenic Potential in Early Drug Development of hERG Channel Blocking Drugs. Reproductive Toxicology, 29(2), 156-163. [More Information]
  • Abela, D., Ritchie, H., Ababneh, D., Gavin, C., Nilsson, M., Khan, M., Carlsson, K., Webster, W. (2010). The effect of drugs with ion channel-blocking activity on the early embryonic rat heart. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 89(5), 429-440. [More Information]

2009

  • Oakes, D., Ritchie, H., Woodman, P., Narup, E., Moscova, M., Picker, K., Webster, W. (2009). Genotoxicity studies of a desealant solvent mixture, SR-51. Toxicology and Industrial Health: An International Journal, 25(1), 5-13. [More Information]

2008

  • Jones, K., Webster, W., Vaux, K., Benirschke, K. (2008). Acardiac fetus: evidence in support of a vascular/hypoxia pathogenesis for isolated oral clefting. Birth Defects Research. Part A: Clinical and Molecular Teratology, 82(8), 597-600. [More Information]

2007

  • Karlsson, M., Danielsson, B., Nilsson, M., Danielsson, C., Webster, W. (2007). New Proposals for Testing Drugs with IKr-Blocking Activity to Determine Their Teratogenic Potential. Current Pharmaceutical Design, 13(29), 2979-2988. [More Information]
  • Webster, W., Abela, D. (2007). The effect of hypoxia in development. Birth Defects Research. Part C: Embryo Today Reviews, 81(3), 215-228. [More Information]

2006

  • Webster, W., Howe, A., Abela, D., Oakes, D. (2006). The relationship between cleft lip maxillary hypoplasia, hypoxia and phenytoin. Current Pharmaceutical Design, 12(12), 1431-1448. [More Information]

2005

  • Abela, D., Howe, A., Oakes, D., Webster, W. (2005). Maternal antioxidant supplementation does not reduce the incidence of phenytoin-induced cleft lip and related malformations in rats. Birth Defects Research. Part B: Developmental and Reproductive Toxicology, 74(2), 201-206. [More Information]

2004

  • Moscova, M., Oakes, D., Pollak, J., Webster, W. (2004). Effects of a desealant formulation, SR-51 and its individual components on the oxidative functions of mitochondria. Environmental Toxicology and Pharmacology, 18(2), 181-184.
  • Howe, A., Hawkins, J., Webster, W. (2004). The Growth Of The Nasal Septum In The 6-9 Week Period Of Foetal Development--Warfarin Embryopathy Offers A New Insight Into Prenatal Facial Development. Australian Dental Journal, 49(4), 171-176.

2003

  • Webster, W., Freeman, J. (2003). Prescription drugs and pregnancy. Expert Opinion on Pharmacotherapy, 4(6), 949-961.

2002

  • Oakes, D., Webster, W., Woodman, P., Ritchie, H. (2002). A Study of the Potential for a Herbicide Formulation Containing 2,4-D and Picloram to Cause Male-Mediated Developmental Toxicity in Rats. Toxicological Sciences, 68(1), 200-206.
  • Oakes, D., Webster, W., Woodman, P., Ritchie, H. (2002). Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D(R) (2,4-dichlorophenoxyacetic acid and picloram)in rats. Reproductive Toxicology, 16(3), 281-289.

2001

  • Webster, W., Freeman, J. (2001). Is this drug safe in pregnancy? Reproductive Toxicology, 15 (6), 619-629.
  • Oakes, D., Webster, W., Woodman, P., Ritchie, H. (2001). Male mediated developmental toxicity and the herbicide formulation, Tordon 75D. Australian Birth Defects Society, : World Scientific Publishing.

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