Dr Boris Guennewig

Senior Lecturer
Central Clinical School.


Curriculum vitae Curriculum vitae

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Biographical details

04/2017 – present Senior Lecturer, Brain & Mind Center, University of Sydney

12/2013 – present Conjoint Lecturer Faculty of Medicine, University of New South Wales.

07/2013 – 02/2017 Bioinformatics Research Officer in Neuroscience with Prof. A Cooper & Prof. JS Mattick at the Garvan Institute of Medical Research in Sydney: “Functional characterization of the complete human brain transcriptome from Parkinson’s disease associated loci.”

09/2008 – 03/2013 PhD in Nucleic Acid Research & Medicinal Chemistry with Dr. H Towbin & Prof. J Hall at the Department of Chemistry and Applied Biosciences at ETH Zurich/Switzerland: “Synthesis-enabled strategies to identify new microRNA biology”.

01/2008 – 07/2008 Diploma theses in Immunology and generating a knock-in mouse with Prof. D Vestweber at the Max Planck Institute for Molecular Biomedicine: “VE-Cadherin mediated regulation of endothelial cell-cell contacts”.

09/2003 – 07/2008 Chemistry Diploma in Muenster/Germany.

Research interests

I am a research scientist/bioinformatician/statistician specializing in the development of infrastructure, software and pipelines to manage, analyze and mine large complex datasets in medical research. Using structured, semi-structured and unstructured data, my research focuses on the identification and characterization of genetic variation and transcriptional changes influencing complex human diseases (such as frontotemporal lobe dementia, bipolar disorder, Parkinson’s and Alzheimer’s disease, etc.). I achieve this through the functional integration of high-dimensional biological (omics) data, in combination with my statistical, genetics and data mining skills. I believe that assimilating and modelling multi-modal data (i.e. imaging, clinical and omic data) is key to uncovering the genotype-phenotype interaction and how this relationship affects complex traits.

Current research students

Project title Research student
The Neurobiology of chronic disease Andrew MCCORKINDALE
Resampling Based Model Selection for Correlated and Complex Data Connor SMITH

Associations

Conjoint Lecturer Faculty of Medicine, University of New South Wales

Visiting Scientist, Garvan Institute of Medical Research

Bioinformatics Lead ICPGC

Awards and honours

02/2016 Invited talk at the Data Science Sydney Meetinghttps://youtu.be/z5Wz3jKk12E 05/2016 Invited talk at Sydney Capital Markets CRC brown bag seminar series.

10/2015 Invited workshop “Current methodologies in transcriptome analysis”. Federal University of Minas Gerais, Belo Horizonte, Brazil.

10/2015 Invited workshop Bioinformatics & Computational Biology X-Meeting 2015 Sao Paulo, Brazil. 08/2015 Finalist Parkinson’s NSW Young Researcher of the Year Award.

03/2015 Keystone Symposia Scholarship & Invited talk: “Long Noncoding RNAs: From Evolution to Function.”

09/2014 8thA+PD Symposium Sydney, Best poster

01/2014 – 01/2016 Early Postdoc Mobility Fellowship Swiss National Science Foundation (P2EZP3_152143).

01/2010 – 12/2012 Project Grant “Chemical biology in microRNA pathways.” Swiss National Science Foundation.

07/2003 – 09/2003 “European International Biotechnology School” in Perugia/Italy (scholarship EU).

In the media

https://youtu.be/z5Wz3jKk12E

Selected publications

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Journals

  • Mladenova, D., Barry, G., Konen, L., Pineda, S., Guennewig, B., Avesson, L., Zinn, R., Schonrock, N., Bitar, M., Jonkhout, N., et al (2018). Adar3 is involved in learning and memory in mice. Frontiers in Neuroscience, 12. [More Information]
  • Guennewig, B., Bitar, M., Obiorah, I., Hanks, J., O'Brien, E., Kaczorowski, D., Hurd, Y., Roussos, P., Brennand, K., Barry, G. (2018). THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders Accepted at Translational Psychiatry. Translational Psychiatry, 8(1), 9. [More Information]
  • Roussos, P., Guennewig, B., Kaczorowski, D., Barry, G., Brennand, K. (2016). Activity-dependent changes in gene expression in schizophrenia human-induced pluripotent stem cell neurons. JAMA Psychiatry, 73(11), 1180-1188. [More Information]
  • Barry, G., Guennewig, B., Fung, S., Kaczorowski, D., Weickert, C. (2015). Long non-coding RNA expression during aging in the human subependymal zone. Frontiers in Neurology, 6. [More Information]
  • Imig, J., Brunschweiger, A., Brummer, A., Guennewig, B., Mittal, N., Kishore, S., Tsikrika, P., Gerber, A., Zavolan, M., Hall, J. (2015). MiR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction. Nature Chemical Biology, 11(2), 107-114. [More Information]
  • Dogar, A., Semplicio, G., Guennewig, B., Hall, J. (2014). Multiple microRNAs derived from chemically synthesized precursors regulate thrombospondin 1 expression. Nucleic Acid Therapeutics, 24(2), 149-159. [More Information]
  • Guennewig, B., Roos, M., Dogar, A., Gebert, L., Zagalak, J., Vongrad, V., Metzner, K., Hall, J. (2014). Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-alpha. RNA, 20(1), 61-75. [More Information]
  • Guennewig, B., Cooper, A. (2014). The central role of noncoding RNA in the brain. International Review of Neurobiology, 116, 153-194. [More Information]
  • Towbin, H., Wenter, P., Guennewig, B., Imig, J., Zagalak, J., Gerber, A., Hall, J. (2013). Systematic screens of proteins binding to synthetic microRNA precursors. Nucleic Acids Research, 41(3). [More Information]
  • Guennewig, B., Stoltz, M., Menzi, M., Dogar, A., Hall, J. (2012). Properties of N 4-methylated cytidines in miRNA mimics. Nucleic Acid Therapeutics, 22(2), 109-116. [More Information]

2018

  • Mladenova, D., Barry, G., Konen, L., Pineda, S., Guennewig, B., Avesson, L., Zinn, R., Schonrock, N., Bitar, M., Jonkhout, N., et al (2018). Adar3 is involved in learning and memory in mice. Frontiers in Neuroscience, 12. [More Information]
  • Guennewig, B., Bitar, M., Obiorah, I., Hanks, J., O'Brien, E., Kaczorowski, D., Hurd, Y., Roussos, P., Brennand, K., Barry, G. (2018). THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders Accepted at Translational Psychiatry. Translational Psychiatry, 8(1), 9. [More Information]

2016

  • Roussos, P., Guennewig, B., Kaczorowski, D., Barry, G., Brennand, K. (2016). Activity-dependent changes in gene expression in schizophrenia human-induced pluripotent stem cell neurons. JAMA Psychiatry, 73(11), 1180-1188. [More Information]

2015

  • Barry, G., Guennewig, B., Fung, S., Kaczorowski, D., Weickert, C. (2015). Long non-coding RNA expression during aging in the human subependymal zone. Frontiers in Neurology, 6. [More Information]
  • Imig, J., Brunschweiger, A., Brummer, A., Guennewig, B., Mittal, N., Kishore, S., Tsikrika, P., Gerber, A., Zavolan, M., Hall, J. (2015). MiR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction. Nature Chemical Biology, 11(2), 107-114. [More Information]

2014

  • Dogar, A., Semplicio, G., Guennewig, B., Hall, J. (2014). Multiple microRNAs derived from chemically synthesized precursors regulate thrombospondin 1 expression. Nucleic Acid Therapeutics, 24(2), 149-159. [More Information]
  • Guennewig, B., Roos, M., Dogar, A., Gebert, L., Zagalak, J., Vongrad, V., Metzner, K., Hall, J. (2014). Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-alpha. RNA, 20(1), 61-75. [More Information]
  • Guennewig, B., Cooper, A. (2014). The central role of noncoding RNA in the brain. International Review of Neurobiology, 116, 153-194. [More Information]

2013

  • Towbin, H., Wenter, P., Guennewig, B., Imig, J., Zagalak, J., Gerber, A., Hall, J. (2013). Systematic screens of proteins binding to synthetic microRNA precursors. Nucleic Acids Research, 41(3). [More Information]

2012

  • Guennewig, B., Stoltz, M., Menzi, M., Dogar, A., Hall, J. (2012). Properties of N 4-methylated cytidines in miRNA mimics. Nucleic Acid Therapeutics, 22(2), 109-116. [More Information]

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