Dr Brent McParland

Senior Lecturer
Bosch Institute, School of Medical Sciences

Telephone +61 2 9036 6477
Fax +61 2 9351 4717

Map

Research interests

Mechanisms that cause exaggerated narrowing of the airways in asthma and COPD.

Investigating whether Australian ticks cause Lyme disease (borreliosis)

Teaching and supervision

Pharmacology Fundamentals (Basic Pharmacology)

Respiratory Diseases (Asthma, COPD, PAH) Autacoid Pharmacology (5HT, NO, Bradykinin, PGs, LTs, Histamine) Drugs in Sport

Selected grants

2014

  • Australia's Lyme-Like Illness: a focus on north-eastern NSW and south-eastern Queensland; Mitrovic A, McParland B; Australian Respiratory Council/Research Support.

2007

  • An investigation into the cellular mechanisms that cause asthma exacerbations during a common cold; Hinton T, Wark P, Wark P, McParland B, Johnston G, Oliver B, Reddel H; Asthma Foundation of NSW/Neil and Norma Hill Foundation Award.
  • An investigation of the mechanisms that cause exaggerated airway narrowing; McParland B; University of Sydney/Newly Appointed Staff.
  • A new approach to understanding asthma: the answer might lie in the protective fluid lining the airways; McParland B; Clive & Vera Ramaciotti Foundation/Clive & Vera Ramaciotti Fndtn.

Selected publications

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Book Chapters

  • McParland, B., Seow, C., Pare, P., Macklem, P. (2005). Mechanics of Airway Narrowing. In Q. Hamid, J. Shannon, J. Martin (Eds.), Physiologic Basis of Respiratory Disease, (pp. 371-380). United States of America: BC Decker Inc.

Journals

  • Van Ly, D., Faiz, A., Jenkins, C., Crossett, B., Black, J., McParland, B., Burgess, J., Oliver, B. (2013). Characterising the Mechanism of Airway Smooth Muscle B2 Adrenoceptor Desensitization by Rhinovirus Infected Bronchial Epithelial Cells. PLoS One, 8(2), 1-17. [More Information]
  • Matthews, S., Succar, P., Jelinek, H., McParland, B., Buckland, M., McLachlan, C. (2012). Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century. Asia-Pacific Journal of Clinical Oncology, 8(3), 213-216. [More Information]
  • Cooper, P., McParland, B., Mitchell, H., Noble, P., Politi, A., Ressmeyer, A., West, A. (2009). Airway mechanics and methods used to visualize smooth muscle dynamics in vitro. Pulmonary Pharmacology and Therapeutics, 22, 398-406. [More Information]
  • Chapman, D., Berend, N., King, G., McParland, B., Salome, C. (2009). Deep inspirations protect against airway closure in nonasthmatic subjects. Journal of Applied Physiology, 107(2), 564-569. [More Information]
  • Trian, T., Qi, G., Moir, L., Burgess, J., Kuo, C., King, N., Reddel, H., Black, J., Oliver, B., McParland, B. (2009). Rhinovirus-induced Exacerbations of Asthma - How is the β2-adrenoceptor Implicated? American Journal of Respiratory Cell and Molecular Biology, 43(2), 227-233. [More Information]
  • An, S., Bai, T., Bates, J., Black, J., Brown, R., Brusasco, V., Chitano, P., Deng, L., King, G., McParland, B., et al (2007). Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. European Respiratory Journal, 29(5), 834-860. [More Information]
  • Matsumoto, H., Moir, L., Oliver, B., Burgess, J., Roth, M., Black, J., McParland, B. (2007). Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma. Thorax, 62(10), 848-854. [More Information]
  • Matsumoto, H., Moir, L., Oliver, B., Burgess, J., Roth, M., Black, J., McParland, B. (2007). Comparison of gel contraction mediated by asthmatic and non-asthmatic airway smooth muscle cells. Thorax, 62(10), 848-854. [More Information]
  • Pare, P., McParland, B., Seow, C. (2007). Structural basis for exaggerated airway narrowing. Canadian Journal of Physiology and Pharmacology, 85(7), 653-658. [More Information]
  • McParland, B., Tait, R., Pare, P., Seow, C. (2005). The Role of Airway Smooth Muscle during an Attack of Asthma Simulated In Vitro. American Journal of Respiratory Cell and Molecular Biology, 33(5), 500-504. [More Information]
  • Herrera, A., McParland, B., Bienkowska, A., Tait, R., Pare, P., Seow, C. (2005). ‘Sarcomeres’ of smooth muscle: functional characteristics and ultrastructural evidence. Journal of Cell Science, 118(11), 2381-2392. [More Information]
  • McParland, B., Pare, P., Johnson, P., Armour, C., Black, J. (2004). Airway Basement Membrane Perimeter In Human Airways Is Not A Constant; Potential Implications For Airway Remodeling In Asthma. Journal of Applied Physiology, 97(2), 556-563.
  • Burgess, J., Johnson, P., Ge, Q., Au, W., Poniris, M., McParland, B., King, G., Roth, M., Black, J. (2003). Expression of connective tissue growth factor in asthmatic airway smooth muscle cells. American Journal of Respiratory and Critical Care Medicine, 167(1), 71-77.
  • Burgess, J., McParland, B. (2002). Analysis of gene expression. Methods in Enzymology, 356(22), 259-270.
  • Ball, H., McParland, B., Driussi, C., Hunt, N. (2002). Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain Research Protocols, 9(3), 206-213.

2013

  • Van Ly, D., Faiz, A., Jenkins, C., Crossett, B., Black, J., McParland, B., Burgess, J., Oliver, B. (2013). Characterising the Mechanism of Airway Smooth Muscle B2 Adrenoceptor Desensitization by Rhinovirus Infected Bronchial Epithelial Cells. PLoS One, 8(2), 1-17. [More Information]

2012

  • Matthews, S., Succar, P., Jelinek, H., McParland, B., Buckland, M., McLachlan, C. (2012). Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century. Asia-Pacific Journal of Clinical Oncology, 8(3), 213-216. [More Information]

2009

  • Cooper, P., McParland, B., Mitchell, H., Noble, P., Politi, A., Ressmeyer, A., West, A. (2009). Airway mechanics and methods used to visualize smooth muscle dynamics in vitro. Pulmonary Pharmacology and Therapeutics, 22, 398-406. [More Information]
  • Chapman, D., Berend, N., King, G., McParland, B., Salome, C. (2009). Deep inspirations protect against airway closure in nonasthmatic subjects. Journal of Applied Physiology, 107(2), 564-569. [More Information]
  • Trian, T., Qi, G., Moir, L., Burgess, J., Kuo, C., King, N., Reddel, H., Black, J., Oliver, B., McParland, B. (2009). Rhinovirus-induced Exacerbations of Asthma - How is the β2-adrenoceptor Implicated? American Journal of Respiratory Cell and Molecular Biology, 43(2), 227-233. [More Information]

2007

  • An, S., Bai, T., Bates, J., Black, J., Brown, R., Brusasco, V., Chitano, P., Deng, L., King, G., McParland, B., et al (2007). Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. European Respiratory Journal, 29(5), 834-860. [More Information]
  • Matsumoto, H., Moir, L., Oliver, B., Burgess, J., Roth, M., Black, J., McParland, B. (2007). Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma. Thorax, 62(10), 848-854. [More Information]
  • Matsumoto, H., Moir, L., Oliver, B., Burgess, J., Roth, M., Black, J., McParland, B. (2007). Comparison of gel contraction mediated by asthmatic and non-asthmatic airway smooth muscle cells. Thorax, 62(10), 848-854. [More Information]
  • Pare, P., McParland, B., Seow, C. (2007). Structural basis for exaggerated airway narrowing. Canadian Journal of Physiology and Pharmacology, 85(7), 653-658. [More Information]

2005

  • McParland, B., Seow, C., Pare, P., Macklem, P. (2005). Mechanics of Airway Narrowing. In Q. Hamid, J. Shannon, J. Martin (Eds.), Physiologic Basis of Respiratory Disease, (pp. 371-380). United States of America: BC Decker Inc.
  • McParland, B., Tait, R., Pare, P., Seow, C. (2005). The Role of Airway Smooth Muscle during an Attack of Asthma Simulated In Vitro. American Journal of Respiratory Cell and Molecular Biology, 33(5), 500-504. [More Information]
  • Herrera, A., McParland, B., Bienkowska, A., Tait, R., Pare, P., Seow, C. (2005). ‘Sarcomeres’ of smooth muscle: functional characteristics and ultrastructural evidence. Journal of Cell Science, 118(11), 2381-2392. [More Information]

2004

  • McParland, B., Pare, P., Johnson, P., Armour, C., Black, J. (2004). Airway Basement Membrane Perimeter In Human Airways Is Not A Constant; Potential Implications For Airway Remodeling In Asthma. Journal of Applied Physiology, 97(2), 556-563.

2003

  • Burgess, J., Johnson, P., Ge, Q., Au, W., Poniris, M., McParland, B., King, G., Roth, M., Black, J. (2003). Expression of connective tissue growth factor in asthmatic airway smooth muscle cells. American Journal of Respiratory and Critical Care Medicine, 167(1), 71-77.

2002

  • Burgess, J., McParland, B. (2002). Analysis of gene expression. Methods in Enzymology, 356(22), 259-270.
  • Ball, H., McParland, B., Driussi, C., Hunt, N. (2002). Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain Research Protocols, 9(3), 206-213.

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