Dr Brigitte Nanan

Scientific Officer
Paediatrics & Child Health, Nepean Clinical School

Telephone +61 2 47342612
Fax +61 2 47342561

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Selected grants

2013

  • Analysis of CD4+HLA-G+ regulatory cells in healthy pregnancy and preeclampsia; Nanan B; Australian Women and Children's Research Foundation (OZWAC)/Medical Research Project Grant.

2012

  • Effects of Vitamine D in the Management of Childhood Atopic Dermatitis on Tregulatory cells; Nanan B; Nepean Medical Research Foundation/Project Grant.

2010

  • Investigating the mechanisms of synchronisation of maternal and fetal T regulatory cells; Nanan R, Nanan B; Australian Women and Children's Research Foundation (OZWAC)/Medical Research Project Grant.

2009

  • Purines study in ICU patients with Sepsis: Ex Vivo single cell analysis of T helper cell-substes and their responsibilities to LPS and ATP in adult septic patients; Nalos M, Nanan B; Nepean Medical Research Foundation/Project Grant.

Selected publications

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Journals

  • Neller, M., Nanan, B., Brennan, R., Hsu, P., Joung, S., Nanan, R., Burrows, S., Miles, J. (2014). Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood. Frontiers in Immunology, 5(33), 1-6. [More Information]
  • Nanan, B., Straubinger, K., Hsu, P., Parnell, G., Tang, B., Xu, B., Makris, A., Hennessy, A., Peek, M., Busch, D., Nanan, R., et al (2013). Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy. Journal of Immunology, 191(1), 145-153. [More Information]
  • Hsu, P., Nanan, B., Dahlstrom, J., Fadia, M., Chandra, A., Peek, M., Nanan, R. (2012). Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia. The American Journal of Pathology: cellular and molecular biology of disease, 181(6), 2149-2160. [More Information]
  • Nalos, M., Nanan, B., Parnell, G., Tang, B., McLean, A., Nanan, R. (2012). Immune effects of interferon gamma in persistent staphylococcal sepsis. American Journal of Respiratory and Critical Care Medicine, 185(1), 110-112. [More Information]
  • Suryani, S., Fulcher, D., Nanan, B., Nanan, R., Wong, M., Shaw, P., Gibson, J., Williams, A., Tangye, S. (2010). Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells. Blood, 115(3), 519-529. [More Information]
  • Ma, C., Suryani, S., Avery, D., Chan, A., Nanan, R., Nanan, B., Deenick, E., Tangye, S. (2009). Early commitment of naive human CD4(+) T cells to the T follicular helper (T-FH) cell lineage is induced by IL-12. Immunology and Cell Biology, 87(8), 590-600.
  • Seddiki, N., Sasson, S., Nanan, B., Munier, M., van Bockel, D., Ip, S., Marriott, D., Pett, S., Nanan, R., Cooper, D., et al (2009). Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease. European Journal of Immunology, 39, 391-403. [More Information]
  • Nanan, B., Nanan, B., Peek, M., Peek, M., Khanam, R., Khanam, R., Richarts, L., Richarts, L., Zhu, E., Zhu, E., Fazekas, B., Fazekas, B., Nanan, R., Nanan, R. (2009). Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. Journal of Immunology, 183(11), 7023-7030. [More Information]
  • Nanan, B., Seddiki, N., Zhu, E., Quent, V., Kelleher, A., Fazekas, B., Nanan, R. (2008). Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype. International Immunology, 20(3), 375-383. [More Information]
  • Nalos, M., Huang, S., Sluyter, R., Khan, A., Nanan, B., Nanan, R., McLean, A. (2008). Host tissue damage signal ATP impairs IL-12 and IFN {gamma} secretion in LPS stimulated whole human blood. Intensive Care Medicine, 34(10), 1891-1897. [More Information]
  • Avery, D., Ma, C., Bryant, V., Nanan, B., Nanan, R., Wong, M., Fulcher, D., Cook, M., Tangye, S. (2008). STAT3 is required for IL-21-induced secretion of IgE from human naïve B cells. Blood, 112(5), 1784-1793. [More Information]
  • Seddiki, N., Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S., Nanan, R., Fazekas, B., et al (2006). Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. The Journal of Experimental Medicine, 203(7), 1693-1700. [More Information]
  • Seddiki, N., Nanan, B., Tangye, S., Alexander, S., Solomon, M., Soon, L., Nanan, R., Fazekas, B. (2006). Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood, 107(7), 2830-2838. [More Information]
  • Berberich-Siebelt, F., Berberich, I., Andrulis, M., Nanan, B., Jha, M., Klein-Hessling, S., Schimpl, A., Serfling, E. (2006). SUMOylation interferes with CCAAT/enhancer-binding protein β-mediated c-myc repression, but not IL-4 activation in T cells. Journal of Immunology, 176(8), 4843-4851. [More Information]
  • Nanan, B., Peek, M., McCullagh, P., Nanan, R. (2005). Therapeutic potential of stem cells in perinatal medicine. Australian and New Zealand Journal of Obstetrics and Gynaecology, 45(2), 102-107. [More Information]
  • Klein-Hessling, S., Jha, M., Nanan, B., Berberich-Siebelt, F., Baumruker, T., Schimpl, A., Serfling, E. (2003). Protein Kinase A Regulates GATA-3-Dependent Activation of IL-5 Gene Expression in Th2 Cells. Journal of Immunology, 170, 2956-2961.
  • Chuvpilo, S., Jankevics, E., Tyrsin, D., Akimzhanov, A., Moroz, D., Jha, M., Schulze-Luehrmann, J., Nanan, B., et, A. (2002). Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis. Immunity, 16, 881-895.
  • Schulze-Luehrmann, J., Nanan, B., Jha, M., Schimpl, A., Avots, A., Seroing, E. (2002). Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes. Blood, 100, 954-960.

2014

  • Neller, M., Nanan, B., Brennan, R., Hsu, P., Joung, S., Nanan, R., Burrows, S., Miles, J. (2014). Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood. Frontiers in Immunology, 5(33), 1-6. [More Information]

2013

  • Nanan, B., Straubinger, K., Hsu, P., Parnell, G., Tang, B., Xu, B., Makris, A., Hennessy, A., Peek, M., Busch, D., Nanan, R., et al (2013). Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy. Journal of Immunology, 191(1), 145-153. [More Information]

2012

  • Hsu, P., Nanan, B., Dahlstrom, J., Fadia, M., Chandra, A., Peek, M., Nanan, R. (2012). Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia. The American Journal of Pathology: cellular and molecular biology of disease, 181(6), 2149-2160. [More Information]
  • Nalos, M., Nanan, B., Parnell, G., Tang, B., McLean, A., Nanan, R. (2012). Immune effects of interferon gamma in persistent staphylococcal sepsis. American Journal of Respiratory and Critical Care Medicine, 185(1), 110-112. [More Information]

2010

  • Suryani, S., Fulcher, D., Nanan, B., Nanan, R., Wong, M., Shaw, P., Gibson, J., Williams, A., Tangye, S. (2010). Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells. Blood, 115(3), 519-529. [More Information]

2009

  • Ma, C., Suryani, S., Avery, D., Chan, A., Nanan, R., Nanan, B., Deenick, E., Tangye, S. (2009). Early commitment of naive human CD4(+) T cells to the T follicular helper (T-FH) cell lineage is induced by IL-12. Immunology and Cell Biology, 87(8), 590-600.
  • Seddiki, N., Sasson, S., Nanan, B., Munier, M., van Bockel, D., Ip, S., Marriott, D., Pett, S., Nanan, R., Cooper, D., et al (2009). Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease. European Journal of Immunology, 39, 391-403. [More Information]
  • Nanan, B., Nanan, B., Peek, M., Peek, M., Khanam, R., Khanam, R., Richarts, L., Richarts, L., Zhu, E., Zhu, E., Fazekas, B., Fazekas, B., Nanan, R., Nanan, R. (2009). Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. Journal of Immunology, 183(11), 7023-7030. [More Information]

2008

  • Nanan, B., Seddiki, N., Zhu, E., Quent, V., Kelleher, A., Fazekas, B., Nanan, R. (2008). Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype. International Immunology, 20(3), 375-383. [More Information]
  • Nalos, M., Huang, S., Sluyter, R., Khan, A., Nanan, B., Nanan, R., McLean, A. (2008). Host tissue damage signal ATP impairs IL-12 and IFN {gamma} secretion in LPS stimulated whole human blood. Intensive Care Medicine, 34(10), 1891-1897. [More Information]
  • Avery, D., Ma, C., Bryant, V., Nanan, B., Nanan, R., Wong, M., Fulcher, D., Cook, M., Tangye, S. (2008). STAT3 is required for IL-21-induced secretion of IgE from human naïve B cells. Blood, 112(5), 1784-1793. [More Information]

2006

  • Seddiki, N., Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S., Nanan, R., Fazekas, B., et al (2006). Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. The Journal of Experimental Medicine, 203(7), 1693-1700. [More Information]
  • Seddiki, N., Nanan, B., Tangye, S., Alexander, S., Solomon, M., Soon, L., Nanan, R., Fazekas, B. (2006). Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood, 107(7), 2830-2838. [More Information]
  • Berberich-Siebelt, F., Berberich, I., Andrulis, M., Nanan, B., Jha, M., Klein-Hessling, S., Schimpl, A., Serfling, E. (2006). SUMOylation interferes with CCAAT/enhancer-binding protein β-mediated c-myc repression, but not IL-4 activation in T cells. Journal of Immunology, 176(8), 4843-4851. [More Information]

2005

  • Nanan, B., Peek, M., McCullagh, P., Nanan, R. (2005). Therapeutic potential of stem cells in perinatal medicine. Australian and New Zealand Journal of Obstetrics and Gynaecology, 45(2), 102-107. [More Information]

2003

  • Klein-Hessling, S., Jha, M., Nanan, B., Berberich-Siebelt, F., Baumruker, T., Schimpl, A., Serfling, E. (2003). Protein Kinase A Regulates GATA-3-Dependent Activation of IL-5 Gene Expression in Th2 Cells. Journal of Immunology, 170, 2956-2961.

2002

  • Chuvpilo, S., Jankevics, E., Tyrsin, D., Akimzhanov, A., Moroz, D., Jha, M., Schulze-Luehrmann, J., Nanan, B., et, A. (2002). Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis. Immunity, 16, 881-895.
  • Schulze-Luehrmann, J., Nanan, B., Jha, M., Schimpl, A., Avots, A., Seroing, E. (2002). Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes. Blood, 100, 954-960.

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