Dr Carl Feng

Senior Lecturer in Immunology
Medicine (Immunology & Infectious Diseases), Central Clinical School

Telephone +61 2 9351 6177
Fax +61 2 9351 5319

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Research interests

Our research is focused on the understanding of the mechanisms mediating host resistance to persistent intracellular pathogens, with the goal of developing novel interventions for preventing and treating chronic infectious diseases in humans. We investigate a range of basic aspects of innate and adaptive immune responses to Mycobacteriumtuberculosis and other intracellular pathogens in mice, from cytokine biology to immune regulation and tissue inflammation in the lungs. To understand the immunological basis of host control of tuberculosis in humans, we are also extending our studies to examine the interplay between Mycobacterium tuberculosis and host signalling pathways in human cells and to identifyimmune correlates of protection in infected human subjects through international collaborations.

Selected grants

2013

  • Dissecting in vivo cellular responses to interferons in pathogen-infected hosts; Feng C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas de St Groth B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Journals

  • Cai, Y., Yang, Q., Tang, Y., Zhang, M., Liu, H., Zhang, G., Deng, Q., Huang, J., Gao, Z., Zhou, B., Feng, C., et al (2014). Increased complement C1q level marks active disease in human tuberculosis. PLoS One, 9(3), e92340- 1-e92340- 11. [More Information]
  • Shenderov, K., Barber, D., Mayer-Barber, K., Gurcha, S., Jankovic, D., Feng, C., Oland, S., Hieny, S., Caspar, P., Yamasaki, S., et al (2013). Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. Journal of Immunology, 190(11), 5722-5730. [More Information]
  • Zhang, G., Zhou, B., Wang, W., Zhang, M., Zhao, Y., Wang, Z., Yang, L., Zhai, J., Feng, G., Wang, J., et al (2012). A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis. The Journal of Infectious Diseases, 205(11), 1697-1704. [More Information]
  • Klionsky, D., Abdalla, F., Abeliovich, H., Abraham, R., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J., Bendall, L., Feng, C., Sidhu, S., Xia, P., et al (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445-544. [More Information]
  • Vazquez, N., Rekka, S., Gliozzi, M., Feng, C., Amarnath, S., Orenstein, J., Wahl, S. (2012). Modulation of Innate Host Factors by Mycobacterium avium Complex in Human Macrophages Includes Interleukin 17. The Journal of Infectious Diseases, 206(8), 1206-1217. [More Information]
  • Henry, S., Daniell, X., Burroughs, A., Indaram, M., Howell, D., Coers, J., Starnbach, M., Hunn, J., Howard, J., Feng, C., et al (2011). Balance of Irgm protein activities determines IFN-gamma-induced host defense. Journal of Leukocyte Biology, 85(5), 877-885. [More Information]
  • Barber, D., Mayer-Barber, K., Feng, C., Sharpe, A., Sher, A. (2011). CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. Journal of Immunology, 186(3), 1598-1607. [More Information]
  • Taylor, G., Feng, C., Sher, A. (2011). Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). Microbes and Infection, 9(14-15), 1644-1651. [More Information]
  • Jankovic, D., Kullberg, M., Feng, C., Goldszmid, R., Collazo, C., Wilson, M., Wynn, T., Kamanaka, M. (2011). Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. The Journal of Experimental Medicine, 204(2), 273-283. [More Information]
  • Rothfuchs, A., Bafica, A., Feng, C., Egen, J., Williams, D., Brown, G., Sher, A. (2011). Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. Journal of Immunology, 179(6), 3463-3471. [More Information]
  • Kullberg, M., Jankovic, D., Feng, C., Hue, S., Gorelick, P., McKenzie, B., Cua, D., Powrie, F., Cheever, A., Maloy, K., et al (2011). IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. The Journal of Experimental Medicine, 203(11), 2485-2494. [More Information]
  • Triccas, J., Winter, N., Feng, C., West, N. (2011). Immunity to Mycobacterium tuberculosis. Clinical & Developmental Immunology, 2011, 406549-406549. [More Information]
  • Rothfuchs, A., Egen, J., Feng, C., Antonelli, L., Bafica, A., Winter, N., Locksley, R., Sher, A. (2011). In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. Journal of Immunology, 182(11), 6915-6925. [More Information]
  • Mayer-Barber, K., Andrade, B., Barber, D., Hieny, S., Feng, C., Caspar, P., Oland, S., Gordon, S., Sher, A. (2011). Innate and adaptive interferons suppress IL-1(alpha) and IL-1(beta) production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity, 35(6), 1023-1034. [More Information]
  • Feng, C., Zheng, L., Lenardo, M., Sher, A. (2011). Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy. Autophagy, 5(2), 232-234. [More Information]
  • Reiman, R., Thompson, R., Feng, C., Hari, D., Knight, R., Cheever, A., Rosenberg, H., Wynn, T. (2011). Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL_13 activity. Infection and Immunity, 74(3), 1471-1479. [More Information]
  • Antonelli, L., Rothfuchs, A., Goncalves, R., Roffe, E., Cheever, A., Bafica, A., Salazar, A., Feng, C., Sher, A. (2011). Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population. Journal of Clinical Investigation, 120(5), 1674-1682. [More Information]
  • Egen, J., Rothfuchs, A., Feng, C., Horwitz, M., Sher, A., Germain, R. (2011). Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity, 34(5), 807-819. [More Information]
  • Feng, C., Kaviratne, M., Rothfuchs, A., Cheever, A., Hieny, S., Young, H., Wynn, T., Sher, A. (2011). NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. Journal of Immunology, 177(10), 7086-7093. [More Information]
  • Feng, C., Wilson, M., Barber, D., Yarovinsky, F., Cheever, A., Sher, A., Griggs, M., Collins, M., Fouser, L., Wynn, T. (2011). Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. Journal of Immunology, 184(8), 4378-4390. [More Information]
  • Goldszmid, R., Bafica, A., Jankovic, D., Feng, C., Caspar, P., Winkler-Pickett, R., Trinchieri, G., Sher, A. (2011). TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production. The Journal of Experimental Medicine, 204(11), 2591-2602. [More Information]
  • Bafica, A., Feng, C., Santiago, H., Aliberti, J., Cheever, A., Thomas, K., Taylor, G., Vogel, S., Sher, A. (2011). The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. Journal of Immunology, 179(8), 5514-5522. [More Information]
  • Hunn, J., Feng, C., Sher, A., Howard, J. (2011). The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mammalian Genome, 22(1-2), 43-54. [More Information]
  • Steinfelder, S., Andersen, J., Cannons, J., Feng, C., Joshi, M., Dwyer, D., Caspar, P., Schwartzberg, P., Sher, A., Jankovic, D. (2011). The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). The Journal of Experimental Medicine, 206(8), 1681-1690. [More Information]
  • Feng, C., Sher, A. (2010). Parasites paralyze cellular host defense system to promote virulence. Cell Host and Microbe, 8(6), 463-464. [More Information]
  • West, N., Wozniak, T., Valenzuela, J., Feng, C., Sher, A., Ribeiro, J., Britton, W. (2008). Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine, 26(31), 3853-3859. [More Information]
  • Alter-Koltunoff, M., Goren, S., Nousbeck, J., Feng, C., Sher, A., Ozato, K., Azriel, A., Levi, B. (2008). Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. Journal of Biological Chemistry, 283(5), 2724-2733. [More Information]
  • Egen, J., Rothfuchs, A., Feng, C., Winter, N., Sher, A., Germain, R. (2008). Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. Immunity, 28(2), 271-284. [More Information]
  • Feng, C., Zheng, L., Jankovic, D., Bafica, A., Cannons, J., Watford, W., Chaussabel, D., Hieny, S., Caspar, P., Schwartzberg, P., et al (2008). The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nature Immunology, 9(11), 1279-1287. [More Information]
  • Feng, C., Weksberg, D., Taylor, G., Sher, A., Goodell, M. (2008). The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell, 2(1), 83-89. [More Information]
  • Feng, C., Britton, W., Demangel, C., Kamath, A., Macdonald, M. (2001). Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8+ T cells with specificity for a novel mycobacterial epitope. International Immunology, 13, 451-458.
  • Feng, C., Britton, W., Blanchard,, T., Smith, G., Hill, A. (2001). Induction of CD8+ T-lymphocyte responses to a secreted antigen of Mycobacterium tuberculosis by an attenuated vaccine virus. Immunology and Cell Biology, 79, 569-575.
  • Feng, C., Umaimainthan, P., Britton, W., Demangel, C., Spratt, J., Malin, A. (2001). Priming by DNA immunization augments protective efficacy of Mycobacterium bovis bacille Calmette-Guerin against tuberculosis. Infection and Immunity, 69, 4174-4176.
  • Umaimainthan, P., Feng, C., Britton, W., Demangel, C., Heath, A., Bean, A. (2001). Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection. Infection and Immunity, 69, 2456-2461.

2014

  • Cai, Y., Yang, Q., Tang, Y., Zhang, M., Liu, H., Zhang, G., Deng, Q., Huang, J., Gao, Z., Zhou, B., Feng, C., et al (2014). Increased complement C1q level marks active disease in human tuberculosis. PLoS One, 9(3), e92340- 1-e92340- 11. [More Information]

2013

  • Shenderov, K., Barber, D., Mayer-Barber, K., Gurcha, S., Jankovic, D., Feng, C., Oland, S., Hieny, S., Caspar, P., Yamasaki, S., et al (2013). Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. Journal of Immunology, 190(11), 5722-5730. [More Information]

2012

  • Zhang, G., Zhou, B., Wang, W., Zhang, M., Zhao, Y., Wang, Z., Yang, L., Zhai, J., Feng, G., Wang, J., et al (2012). A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis. The Journal of Infectious Diseases, 205(11), 1697-1704. [More Information]
  • Klionsky, D., Abdalla, F., Abeliovich, H., Abraham, R., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J., Bendall, L., Feng, C., Sidhu, S., Xia, P., et al (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445-544. [More Information]
  • Vazquez, N., Rekka, S., Gliozzi, M., Feng, C., Amarnath, S., Orenstein, J., Wahl, S. (2012). Modulation of Innate Host Factors by Mycobacterium avium Complex in Human Macrophages Includes Interleukin 17. The Journal of Infectious Diseases, 206(8), 1206-1217. [More Information]

2011

  • Henry, S., Daniell, X., Burroughs, A., Indaram, M., Howell, D., Coers, J., Starnbach, M., Hunn, J., Howard, J., Feng, C., et al (2011). Balance of Irgm protein activities determines IFN-gamma-induced host defense. Journal of Leukocyte Biology, 85(5), 877-885. [More Information]
  • Barber, D., Mayer-Barber, K., Feng, C., Sharpe, A., Sher, A. (2011). CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. Journal of Immunology, 186(3), 1598-1607. [More Information]
  • Taylor, G., Feng, C., Sher, A. (2011). Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). Microbes and Infection, 9(14-15), 1644-1651. [More Information]
  • Jankovic, D., Kullberg, M., Feng, C., Goldszmid, R., Collazo, C., Wilson, M., Wynn, T., Kamanaka, M. (2011). Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. The Journal of Experimental Medicine, 204(2), 273-283. [More Information]
  • Rothfuchs, A., Bafica, A., Feng, C., Egen, J., Williams, D., Brown, G., Sher, A. (2011). Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. Journal of Immunology, 179(6), 3463-3471. [More Information]
  • Kullberg, M., Jankovic, D., Feng, C., Hue, S., Gorelick, P., McKenzie, B., Cua, D., Powrie, F., Cheever, A., Maloy, K., et al (2011). IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. The Journal of Experimental Medicine, 203(11), 2485-2494. [More Information]
  • Triccas, J., Winter, N., Feng, C., West, N. (2011). Immunity to Mycobacterium tuberculosis. Clinical & Developmental Immunology, 2011, 406549-406549. [More Information]
  • Rothfuchs, A., Egen, J., Feng, C., Antonelli, L., Bafica, A., Winter, N., Locksley, R., Sher, A. (2011). In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. Journal of Immunology, 182(11), 6915-6925. [More Information]
  • Mayer-Barber, K., Andrade, B., Barber, D., Hieny, S., Feng, C., Caspar, P., Oland, S., Gordon, S., Sher, A. (2011). Innate and adaptive interferons suppress IL-1(alpha) and IL-1(beta) production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity, 35(6), 1023-1034. [More Information]
  • Feng, C., Zheng, L., Lenardo, M., Sher, A. (2011). Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy. Autophagy, 5(2), 232-234. [More Information]
  • Reiman, R., Thompson, R., Feng, C., Hari, D., Knight, R., Cheever, A., Rosenberg, H., Wynn, T. (2011). Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL_13 activity. Infection and Immunity, 74(3), 1471-1479. [More Information]
  • Antonelli, L., Rothfuchs, A., Goncalves, R., Roffe, E., Cheever, A., Bafica, A., Salazar, A., Feng, C., Sher, A. (2011). Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population. Journal of Clinical Investigation, 120(5), 1674-1682. [More Information]
  • Egen, J., Rothfuchs, A., Feng, C., Horwitz, M., Sher, A., Germain, R. (2011). Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity, 34(5), 807-819. [More Information]
  • Feng, C., Kaviratne, M., Rothfuchs, A., Cheever, A., Hieny, S., Young, H., Wynn, T., Sher, A. (2011). NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. Journal of Immunology, 177(10), 7086-7093. [More Information]
  • Feng, C., Wilson, M., Barber, D., Yarovinsky, F., Cheever, A., Sher, A., Griggs, M., Collins, M., Fouser, L., Wynn, T. (2011). Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. Journal of Immunology, 184(8), 4378-4390. [More Information]
  • Goldszmid, R., Bafica, A., Jankovic, D., Feng, C., Caspar, P., Winkler-Pickett, R., Trinchieri, G., Sher, A. (2011). TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production. The Journal of Experimental Medicine, 204(11), 2591-2602. [More Information]
  • Bafica, A., Feng, C., Santiago, H., Aliberti, J., Cheever, A., Thomas, K., Taylor, G., Vogel, S., Sher, A. (2011). The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. Journal of Immunology, 179(8), 5514-5522. [More Information]
  • Hunn, J., Feng, C., Sher, A., Howard, J. (2011). The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mammalian Genome, 22(1-2), 43-54. [More Information]
  • Steinfelder, S., Andersen, J., Cannons, J., Feng, C., Joshi, M., Dwyer, D., Caspar, P., Schwartzberg, P., Sher, A., Jankovic, D. (2011). The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). The Journal of Experimental Medicine, 206(8), 1681-1690. [More Information]

2010

  • Feng, C., Sher, A. (2010). Parasites paralyze cellular host defense system to promote virulence. Cell Host and Microbe, 8(6), 463-464. [More Information]

2008

  • West, N., Wozniak, T., Valenzuela, J., Feng, C., Sher, A., Ribeiro, J., Britton, W. (2008). Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine, 26(31), 3853-3859. [More Information]
  • Alter-Koltunoff, M., Goren, S., Nousbeck, J., Feng, C., Sher, A., Ozato, K., Azriel, A., Levi, B. (2008). Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. Journal of Biological Chemistry, 283(5), 2724-2733. [More Information]
  • Egen, J., Rothfuchs, A., Feng, C., Winter, N., Sher, A., Germain, R. (2008). Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. Immunity, 28(2), 271-284. [More Information]
  • Feng, C., Zheng, L., Jankovic, D., Bafica, A., Cannons, J., Watford, W., Chaussabel, D., Hieny, S., Caspar, P., Schwartzberg, P., et al (2008). The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nature Immunology, 9(11), 1279-1287. [More Information]
  • Feng, C., Weksberg, D., Taylor, G., Sher, A., Goodell, M. (2008). The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell, 2(1), 83-89. [More Information]

2001

  • Feng, C., Britton, W., Demangel, C., Kamath, A., Macdonald, M. (2001). Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8+ T cells with specificity for a novel mycobacterial epitope. International Immunology, 13, 451-458.
  • Feng, C., Britton, W., Blanchard,, T., Smith, G., Hill, A. (2001). Induction of CD8+ T-lymphocyte responses to a secreted antigen of Mycobacterium tuberculosis by an attenuated vaccine virus. Immunology and Cell Biology, 79, 569-575.
  • Feng, C., Umaimainthan, P., Britton, W., Demangel, C., Spratt, J., Malin, A. (2001). Priming by DNA immunization augments protective efficacy of Mycobacterium bovis bacille Calmette-Guerin against tuberculosis. Infection and Immunity, 69, 4174-4176.
  • Umaimainthan, P., Feng, C., Britton, W., Demangel, C., Heath, A., Bean, A. (2001). Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection. Infection and Immunity, 69, 2456-2461.

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