Dr Carmine Gentile

Lecturer. Northern Clinical School
Kolling Institute, Royal North Shore Hospital
Visiting Research Fellow in Medicine, Beth Israel Deaconess Medical Center - Harvard Medical School

Telephone +61 2 9926 4937

Website ABC News 24 Interview
Research Fellow at Harvard Medical School
ABC Catalyst "Heartbeat: The Miracle Inside You"

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Biographical details

EDUCATION/TRAINING

INSTITUTION AND LOCATION

DEGREE

YEAR(s)

FIELD OF STUDY

University of Pisa, Italy

B.Sc./M.Sc.

1999-2004

Chemistry and Pharmaceutical Technologies

University of Pisa, Italy

Pharm.D.

2004

Pharmacy

Medical University of South Carolina, Charleston, SC, USA

Ph.D.

2008-2013

Biomedical Sciences –Molecular and Cell Biology Program –Cardiovascular

  • Professional Experience:

2004 April - October

Graduate Student, Institute of Clinical Physiology (Italian National

Research Council, CNR), Interdepartmental Research Center “E. Piaggio” (Faculty of Engineering), and Faculty of Pharmacy, University of Pisa, Italy (Supervisors: Dr. Claudio Domenici, Prof. Arti Ahluwalia, Dr. Giovanni Vozzi and Prof. Enrica Martinotti)

2005 February -September

Pharmacist, Farmacia “José Eugenio Piñero Correa”, Canary Islands, Spain

2006 December

Research Associate, Institute of Clinical Physiology (Italian National

Research Council, CNR) and Interdepartmental Research Center “E.

Piaggio” (Faculty of Engineering) in Pisa, Italy (Supervisor: Dr. Giovanni Vozzi)

2006 - 2008

Research Fellow, Cell Biology and Anatomy, MUSC, Charleston, SC, USA (Supervisors: Prof. Christopher J. Drake and Dr. Vladimir Mironov)

Summer 2006 and 2007

Supervisor of summer students (Prof. Drake laboratory)

2006 October - November

Visiting Research Fellow, Biotechnologisch-Biomedizinisches Zentrum

(BBZ), University of Leipzig, Germany (Supervisor: Prof. Augustinus Bader)

2007 October - November

Visiting Research Fellow, Institute for Membrane Technology (Italian

National Research Council, CNR), Arcavacata, Italy (Supervisor: Dr. Loredana De Bartolo)

2008-2013

Graduate Assistant, Department of Regenerative Medicine and Cell

Biology, MUSC, Charleston, SC, USA (Mentor: Prof. Christopher J. Drake)

2011-2013

Supplemental Instructorfor Medicinal Chemistry II and III,

Pharmaceutical Chemistry and Pharmacogenomics I and II, College of

Pharmacy, MUSC, Charleston, SC, USA

2013-2016

Postdoctoral Research Fellow,Free Radical Group, The Heart Research Institute, Newtown, NSW, Australia (External Supervisor: Prof. Michael J. Davies/On site Supervisor: Dr. David Pattison)

2013-2016

Conjoint Lecturer (Level B), Sydney Medical School, University of Sydney, NSW, Australia

2016-present Visiting Research Fellow, Beth Israel Deaconess Medical Center - Harvard Medical School (Supervisor: Prof. Federica del Monte)
2017-present Lecturer, Sydney Medical School (Northern Clinical), University of Sydney, NSW, Australia

Current projects

  • 3D Bioprinting of the human heart using stem cells;
  • In vitro 3D models to study cardiovascular biology, physiology and pathology;
  • The role of the eNOS signaling pathway in cardiovascular development and regeneration.

Associations

  • American Association of Anatomists (AAA);
  • Australian Atherosclerosis Society (AAS);
  • American Heart Association (AHA);
  • American Physiologist Society (APS);
  • Australian Vascular Biology Society (AVBS);
  • Biophysical Society (BPS);
  • High Blood Pressure Research Council of Australia (HBPRCA);
  • Society for Free Radical Biology and Medicine (SFRBM);
  • Tissue Engineering and Regenerative Medicine International Society (TERMIS).

Awards and honours

  • 2017 Heart Research Australia Award for Discovery Biomedical Research (Sydney, Australia);
  • 2016 Ian Potter Foundation Award (Melbourne, Australia);
  • 2016 AAS Travel Grant to visit Prof Federica del Monte at Harvard Medical School (Australia);
  • 2015 Young Investigator Award (Society for Redox Biology and Medicine Meeting, Boston, USA);
  • 2015 Charles Perkins Centre Young Achiever Award (Sydney, Australia);
  • 2014 Early Career Reasearcher Travel Award (Society for Free Radical Biology and Medicine Annual Meeting, Seattle, USA);
  • 2013 First prize for outstanding oral presentation by an early career researcher (Australian Vascular Biology Society Meeting, Barossa Valley, Australia);
  • 2013-2016 Marcus Blackmore Postdoctoral Research Fellowship (Heart Research Institute, Sydney, Australia);
  • 2011-2013 American Heart Association (AHA) Pre-doctoral Fellowship (USA);
  • 2011 American Association of Anatomists (AAA) Student Travel Award (Experimental Biology Meeting, Washington DC, USA);
  • 1999-2004 PharmD Fellowship (University of Pisa, Italy).

In the media

International links

Australia

(Baker IDI) Prof Rebecca Ritchie - Human cardiac spheroids as models to study redox signaling in diabetes

Australia

(University of New South Wales) Dr Damia Mawad - Conductive hydrogels for 3D bioprinting of the human heart

Australia

(Victor Chang Cardiac Research Centre) Prof Michael Feneley - The role of nitric oxide in cardiac regeneration

Denmark

(University of Copenhagen) Prof Michael J Davies - The role of nitric oxide in cardiovascular regeneration

Italy

(University of Pisa, Pisa) Prof Giovanni Vozzi - "E. Piaggio" Bioengineering Centre - 3D bioprinting of the human heart

Spain

(REGEMAT3D) Dr José Manuel Baena - 3D bioprinting of human cardiac patches

United States

(Beth Israel Deaconess Medical Center - Harvard Medical School) Prof Federica del Monte - Cardiac physiology in human 3D systems

Selected grants

2017

  • Bioprinting human cardiac patches for heart regeneration; Gentile C; Sydney Medical School Foundation/Cardiothoracic Surgery Research Grant Scheme.
  • Bioprinted cardiac spheroids as novel models of the human heart; Gentile C; Sydney Medical School/Kickstart Grant.
  • A new paradigm in redox-mediated cardiac fibrosis; Figtree G, Blaxall B, Kizana E, Xie Z, hayward C, Gentile C; National Health and Medical Research Council (NHMRC)/Project Grants.

2016

  • Bioprinting of human cardiac patches for Heart Regeneration using spheroids from human pluripotent stem cells.; Gentile C; Ian Potter Foundation/Research Grants.

Selected publications

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Journals

  • Galougahi, K., Liu, C., Garcia, A., Gentile, C., Fry, N., Hamilton, E., Hawkins, C., Figtree, G. (2016). Beta3 adrenergic stimulation restores nitric oxide/redox balance and enhances endothelial function in hyperglycemia. Journal of the American Heart Association, 5(2), 1-17. [More Information]
  • Gentile, C. (2016). Filling the Gaps between the In Vivo and In Vitro Microenvironment: Engineering of Spheroids for Stem Cell Technology. Current Stem Cell Research & Therapy, 11(8), 652-665. [More Information]
  • Di Bartolo, B., Cartland, S., Prado-Lourenco, L., Griffith, T., Gentile, C., Ravindran, J., Azahri, N., Thai, T., Yeung, A., Thomas, S., Kavurma, M. (2015). Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms. Journal of the American Heart Association, 4(11), 1-17. [More Information]
  • Galougahi, K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N., Davies, M., Hawkins, C., Rasmussen, H., Figtree, G. (2014). Glutathionylation Mediates Angiotension II-Induced eNOS Uncoupling, Amplifying NADPH Oxidase-Dependent Endothelial Dysfunction. Journal of the American Heart Association, 3(2), 1-11. [More Information]
  • Gentile, C., Muise-Helmericks, R., Drake, C. (2013). VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation. Developmental Biology, 373(1), 163-175. [More Information]

2016

  • Galougahi, K., Liu, C., Garcia, A., Gentile, C., Fry, N., Hamilton, E., Hawkins, C., Figtree, G. (2016). Beta3 adrenergic stimulation restores nitric oxide/redox balance and enhances endothelial function in hyperglycemia. Journal of the American Heart Association, 5(2), 1-17. [More Information]
  • Gentile, C. (2016). Filling the Gaps between the In Vivo and In Vitro Microenvironment: Engineering of Spheroids for Stem Cell Technology. Current Stem Cell Research & Therapy, 11(8), 652-665. [More Information]

2015

  • Di Bartolo, B., Cartland, S., Prado-Lourenco, L., Griffith, T., Gentile, C., Ravindran, J., Azahri, N., Thai, T., Yeung, A., Thomas, S., Kavurma, M. (2015). Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms. Journal of the American Heart Association, 4(11), 1-17. [More Information]

2014

  • Galougahi, K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N., Davies, M., Hawkins, C., Rasmussen, H., Figtree, G. (2014). Glutathionylation Mediates Angiotension II-Induced eNOS Uncoupling, Amplifying NADPH Oxidase-Dependent Endothelial Dysfunction. Journal of the American Heart Association, 3(2), 1-11. [More Information]

2013

  • Gentile, C., Muise-Helmericks, R., Drake, C. (2013). VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation. Developmental Biology, 373(1), 163-175. [More Information]

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