Professor Christopher Little

Director Raymond Purves Bone and Joint Research Labs
Surgery, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T: 02 9926 4800
F: 02 9926 5266

Curriculum vitae

Biographical details

Professor Christopher Little is director of the Raymond Purves Bone and Joint Research Labs at the Kolling Institute of Medical Research at Royal North Shore Hospital, Australia. Chris is a qualified Veterinarian with specialist surgery training and ACVS certification. He was awarded a PhD degree from the University of Sydney in 1996 for his studies of cartilage degradation in a sheep model of osteoarthritis (OA). Following a 5-year postdoctoral position at Cardiff University (UK), he was awarded an Arthritis Foundation of Australia Fellowship at the University of Melbourne. In 2004 he moved to his current position in the University of Sydney Faculty of Medicine. Chris’s research interests focus on defining the biochemical and molecular mechanisms of joint pathology in OA, and tendon and intervertebral disc degeneration, and are based on the belief that it is only though a better understanding the mechanisms that drive the initiation and progression of these diseases that new therapies can be developed. Chris is recognized internationally for his expertise in the development and use of animal models of bone and joint disease. He has served as an Associate Editor of Osteoarthritis and Cartilage, and a leader of the OARSI international initiative to establish standardised methods for evaluation of animal models of OA. Chris received the 2010 Barry Preston Award from the Matrix Biology Society of Australia and New Zealand, presented to an outstanding leader in the field. He has authored/co-authored 104 scientific papers and 7 book chapters.

Current national competitive grants*


Synovial macrophages and T-cells are therapeutic targets in osteoarthritis
Little C, Hunter D
NHMRC Project Grant ($632,127 over 3 years)


Nano-mechanical and nano-structural investigation of dentine: unravelling a novel nano-scale regulator of high durability of mineralised tissues.
Swain M, Little C
ARC Discovery Projects ($370,000 over 3 years)

The calcium channel TRPV4 in skeletal development and arthritis
Little C, McIntyre P
NHMRC Project Grant ($96,000 over 3 years)

Sclerostin Is A Key Regulator Of Wnt Signalling In Bone And Cartilage Pathology In Osteoarthritis
Little C, Sambrook P
NHMRC Project Grants ($571,010 over 3 years)

* Grants administered through the University of Sydney