Dr Chia-Chi Liu
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Research Fellow
E25 - Royal North Shore Hospital |
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Biographical details
I am a senior cardiac researcher at the University of Sydney, based at North Shore Heart Research Group at Sydney Royal North Shore Hospital. I completed my PhD in chemistry and bio-molecular science at Macquarie University in 2007 and was appointed a post-doctorate research fellow in 2008. I obtained two Masters Degrees in Biotechnology at the University of New South Wales, and Cell and Molecular Biology at Taipei Medical University where I was a lecturer in biochemistry. I am using myextensive research expertise and knowledge to investigate the relationship between oxidative stress and the sodium potassium pump function in the heart.
Research interests
My previous research had concentrated on the potentially damaging reactions of the precursors of protein hydroperoxides, protein carbon-centred and peroxyl radicals. My doctoral thesis showed not only that hydroperoxides can damage biological molecules, such as DNA, Lipids, enzymes and antioxidants, but also that they from in human blood serum and in cultured cells exposed to free radicals. Recently, I had focused my study on the protein glutathionylation of Na+-K+ ATPase which triggerd by oxidative stress. My work has led to a number of exciting and novel findings, which open a new direction in the biological effects and the singling pathways by oxidative stress in Na+-K+ ATPase. This offers promise of successful prevention and potential treatment of cardiovascular diseases.
International links
United States. (Burnham Institute for Medical Research) Collaboration with Assistant Professor,FRANCESCA MARASSI in the synthesis of recombinant proteins, FXYD/FXYD mutants..
Denmark. (Department of Physiology and Biophysics, Aarhus University,) Collaboration with Professor Flemming Collaboration with Professor Flemming Cornelius, investigating the effect of oxidative signals on Na+-K+ ATPase kinetics. ..
Switzerland. (Department of Pharmacology and Toxicology, University of Lausanne) Working with Professor Kaethi Geering and Dr Stephanie Bibert to identify the candidate cysteine residue on the beta 1 subunit of Na+-K+ pump subunit that mediates its oxidative regulation. The Geering Laboratory is internationally known for electrophysiology and molecular studies of the Na+-K+ pump in Xenopus oocytes.