Dr Chia-chi Liu

Senior Research Fellow
Medicine, Northern Clinical School
Justice of the Peace

Telephone +61 2 9926 4916
Fax +61 2 9926 5050

Map

Biographical details

Dr Liu is a Senior Research Fellow and Molecular Biologist with expertise in oxidative protein chemistry at University of Sydney. She was a Biochemistry Lecturer in Taipei Medical University Taiwan. Dr Liu completed MSc in Cell and Molecular Biology at Taipei Medical University Taiwan, followed bysecond MSc in Biotechnology, University of New South Wales. She then completed her PhD within the Department of Chemistry and Biomolecular Science, Macquarie University.

Research interests

Dr Liu’s research interests are to translate fundamental molecular discoveries made in the laboratory, into novel pharmaceutical therapies and treatment strategies for heart failure; to establish novel oxidative stress biomarkers to diagnose and monitor the progression of cardiovascular disease and diabetics; and to pioneer therapeutic proteins to improve cancer treatments.

Teaching and supervision

All of Dr Liu's teaching is research led and draws from recent research within the discipline. Her teaching is geared towards supervising undergraduate, medical and postgraduate students. As a researcher and teacher, she believe it isher responsibility to challenge and support her students in pursuit of three key learning goals that: (1) develop critical thinking skills to address concepts about crucial research ideas; (2) learn basic research concepts and skills; (3) cultivate an interest in science, and an understanding of how research is undertaken.

Current research students

Project title Research student
Cardiac glycosides and the membrane Na+-K+ pump. Yeon Jae KIM

Current projects

Targeting Na,K-ATPase with FXYD3 peptide analogues in pancreatic cancer treatment

Targeting Na,K-ATPase with FXYD3 peptide analogues in cancer treatment- prevention of cardiac side effects

Is treatment with an aldosterone antagonist beneficial in heart failure when co-administered with a beta 3 adrenergic agonist?

Roles of glutathione S-transferase and glutaredoxin in redox regulation of the membrane Na+, K+ ATPase

Associations

  • Member of Society for Free Radical Research-Asia
  • Free Radical Biology and Medicine: Scientific Judge/Committee and Fellowship Reviewer
  • Member of The Australian Society for Medical Research
  • Member of International Society for Heart Research
  • Justices of the Peace

Awards and honours

  • 2015-2016 Ramsay Research and Teaching Fund
  • 2015 Early Career Researcher Overseas Travel Grant, University of Sydney
  • 2015 DVC Research/Bridging Support Fellowship
  • 2013-2014 National Heart Foundation Postdoctoral Fellow
  • 2014 Kolling Travel Award – International, Kolling Medical Research Institute

International links

Australia

(Chemistry & Biomolecular Sciences, Macquarie University) Collaborating with A/Professor Jan Gebicki to study the effects of FXYD derivatives on Na pump regulation in cancer cells under gamma irradiation.

Australia

(Head of Cellular and Diagnostic Proteomics Laboratory, Kolling Institute) collaborating with Professor Robert Baxter to test the in vivo toxicity of FXYD derivatives in mouse cancer modols.

Australia

(School of Chemistry, University of Sydney) A/Professor Richard Payne: we aim to design and produce FXYD3 analogues, functional and stable for in vivo delivery.

Australia

(School of Chemistry, University of Sydney) Dr Ronald J. Clarke: This association aims to study the role of pump conformation in susceptibility of ROS by kinetic modelling and the stopped-flow studies on isolated Na+-K+ pump enzyme.

Denmark

(Department of Physiology and Biophysics, Aarhus University,) Collaboration with Professor Flemming Cornelius, investigating the effect of oxidative signals on Na+-K+ ATPase kinetics.

Denmark

(National University Hospital, Rigshospitalet, Copenhagen, Denmark) Collaborating with Dr Henning Bundgaard to establish a phase II clinical trial of a β3 adrenergic receptor agonist (Mirabegron) in Copenhagen.

Switzerland

(Department of Pharmacology and Toxicology, University of Lausanne) Working with Professor Kaethi Geering and Dr Stephanie Bibert to identify the candidate cysteine residue on the beta 1 subunit of Na+-K+ pump subunit that mediates its oxidative regulation. The Geering Laboratory is internationally known for electrophysiology and molecular studies of the Na+-K+ pump in Xenopus oocytes

United States

(Burnham Institute for Medical Research) Collaboration with Assistant Professor FRANCESCA MARASSI in the synthesis of recombinant proteins, FXYD/FXYD mutants.

Selected grants

2017

  • Treating pancreatic cancer with FXYD3 peptide analogues; Rasmussen H, Baxter R, Smith R, Liu C, Howell V; Avner Pancreatic Cancer Foundation/Research support.

2015

  • Targeting Na,K-ATPase with FXYD3 peptide analogues in cancer treatment - prevention of cardiac side effectd; Liu C; DVC Research/Bridging Support Fellowship.

2014

  • Enzymatic Redox regulation of the Na+ pump; Rasmussen H, Liu C; Heart Research Australia./Research Support.
  • A novel drug combination therapy for heart failure; Liu C, Rasmussen H; Heart Research Australia./Research Support.
  • PDE5 inhibitor/beta 3 agonist combination therapy in heart failure; Rasmussen H, Hamilton E, Liu C; Heart Research Australia./Research Support.

2013

  • Combined use of established treatments with a promising new group of drugs in heart failure; Liu C; National Heart Foundation of Australia/Postdoctoral Fellowships (Biomedical, Clinical, Public Health, Health Services).
  • Reversing oxidative inhibition of the Na+-K+ pump by ASP9531: implications for heart failure therapy; Liu C, Hamilton E; Heart Research Australia/Research Support.
  • Functional interaction of oxidative modification sites of the membrane NA+-K+ pump complex; Liu C; Heart Research Australia/Research Support.

2012

  • Effect of 3 adrenergic agonists on the cardiac myocyte Na+-K+ pump with background neurohormonal activation; Liu C; Heart Research Australia/Research Support.
  • Effect of B3 adrenergic agonists on the cardiac myocyte Na+ - K+pump; Liu C; Northern Sydney Local Health District/Research Support.
  • Early Career Researcher Overseas Travel Grant; Liu C; Sydney Medical School/Early Career Researcher Overseas Travel Grant.
  • Inhibition of protein hydroperoxides formation by FXYD proteins; Liu C; Heart Research Australia/Research Support.

2011

  • Analysis of reactive thiol oxidation of beta-1 subunit in Na+-K+ ATPases by mass spectrometry; Liu C; Sydney Medical School/New Staff - Early Career Researcher Scheme.
  • Phospholemman: a rescue protein in heart attack; Liu C, Figtree G, Rasmussen H; Heart Research Australia/Research Support.
  • Protein oxidative modification measurement by a sensitive ELISA method for heart failure and diabetes; Liu C; Heart Research Australia/Research Support.
  • Effect of ACE inhibitors and B- receptor blockers on oxidative Na-K pump modification in cardiac myocytes; Rasmussen H, Liu C; Heart Research Australia/Research Support.

2010

  • Molecular mechanism of insulin induced Na+-K+ pump stimulation in cardiac myocytes; Liu C, Rasmussen H, Figtree G; Heart Research Australia/Research Support.

2009

  • Rapid and reversible ocidative modification: a key mechanism of hormonal regulation of the cardiac Na+-K+; Rasmussen H, Figtree G, Liu C; Heart Research Australia/Research Support.
  • Rapid and reversible oxidative modification: a key mechanism of hormonal regulation of the cardiac Na+-K+ pump; Liu C, Figtree G, Rasmussen H; Heart Research Australia/Research Support.

Selected publications

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Books

  • Liu, C. (2014). Oxidation Of Ascorbate By Protein Radicals. Saarbrucken: Scholars' Press.

Journals

  • Galougahi, K., Liu, C., Garcia, A., Gentle, C., Fry, N., Hamilton, E., Hawkins, C., Figtree, G. (2016). Beta3 adrenergic stimulation restores nitric oxide/redox balance and enhances endothelial function in hyperglycemia. Journal of the American Heart Association, 5(2), 1-17. [More Information]
  • Garcia, A., Liu, C., Cornelius, F., Clarke, R., Rasmussen, H. (2016). Glutathionylation-dependence of Na+ -K+ -pump currents can mimic reduced subsarcolemmal Na+ diffusion. Biophysical Journal, 110(5), 1099-1109. [More Information]
  • Liu, C., Teh, R., Mozar, C., Baxter, R., Rasmussen, H. (2016). Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and y -radiation on Na+/K+-ATPase and cell survival. Breast Cancer Research and Treatment, 155(2), 203-213. [More Information]
  • Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Figtree, G., Rasmussen, H. (2015). Beta3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade. American Journal of Physiology: Cell Physiology, 309(5), C286-C295. [More Information]
  • Chia, K., Liu, C., Hamilton, E., Garcia, A., Fry, N., Hannam, W., Figtree, G., Rasmussen, H. (2015). Stimulation of the cardiac myocyte NA+-K+ pump due to reversal of its constitutive oxidative inhibition. American Journal of Physiology: Cell Physiology, 309(4), C239-C250. [More Information]
  • Grieve, S., Lonborg, J., Mazhar, J., Tan, T., Ho, E., Liu, C., Lay, W., Gill, A., Kuchel, P., Bhindi, R., Figtree, G. (2013). Cardiac magnetic resonance imaging of rapid VCAM-1 up-regulation in myocardial ischemia-reperfusion injury. European Biophysics Journal, 42(1), 61-70. [More Information]
  • Garcia, A., Fry, N., Karimi, K., Liu, C., Apell, H., Rasmussen, H., Clarke, R. (2013). Extracellular allosteric Na+ binding to the Na+, K+-ATPase in cardiac myocytes. Biophysical Journal, 105(12), 2695-2705. [More Information]
  • Liu, C., Galougahi, K., Weisbrod, R., Hansen, T., Ravaie, R., Nunez, A., Liu, Y., Fry, N., Garcia, A., Hamilton, E., Figtree, G., et al (2013). Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction. Free Radical Biology and Medicine, 65(2013), 563-572. [More Information]
  • Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]
  • Galougahi, K., Liu, C., Bundgaard, H., Rasmussen, H. (2012). Beta-Adrenergic Regulation of the Cardiac Na+-K+ ATPase Mediated by Oxidative Signaling. Trends In Cardiovascular Medicine, 22(4), 83-87. [More Information]
  • Liu, C., Gebicki, J. (2012). Intracellular GSH and ascorbate inhibit radical-induced protein chain peroxidation in HL-60 cells. Free Radical Biology and Medicine, 52(2), 420-426. [More Information]
  • Figtree, G., Galougahi, K., Liu, C., Rasmussen, H. (2012). Oxidative regulation of the Na+ -K+ pump in the cardiovascular system. Free Radical Biology and Medicine, 53(12), 2263-2268. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]
  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]
  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Rasmussen, H., Liu, C., Figtree, G. (2010). Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology. Trends In Cardiovascular Medicine, 20(3), 85-90. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]
  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]

Conferences

  • Liu, C., Seow, J., Figtree, G., Rasmussen, H. (2013). Oxidative modification after sheep myocardial infarction-glutathionylation of the beta 1 subunit in cardiac Na+-K+ pump. Society for Free Radical Biology & Medicine 16th Annual Meeting, San Francisco, USA: Society for Free Radical Biology & Medicine.
  • Figtree, G., White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2013). PKA inhibits the Na+-K+ pump via PKC-dependent activation of NAD(P)H oxidase and is associated with oxidative modification of the β1 pump subunit in cardiac myocytes. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Liu, C., Fry, N., Karimi Galougahi, K., Rasmussen, H., Figtree, G. (2012). Glutathionylation of Erythrocyte Na-K Pump in Heart Failure: A Novel Biomarker That Reflects a Key Oxidative Abnormality In the Heart. American Heart Association Scientific Sessions, Not published: Not Published.
  • Liu, C., Armstrong, N., Figtree, G., Rasmussen, H. (2012). Oxidative inhibition of erythrocyte Na+-K+ pump in diabetes: a functionally relevant circulating marker of oxidative stress. 3rd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy: Societa Italiana di Farmacologia.
  • Liu, C., Cornelius, F., Clarke, R., Rasmussen, H. (2011). Oxidant-induced glutathionylation of Na+-K+ ATPase: dependent on the Conformational states? Na, K-ATPase and Related P-ATPase: Structure, Biology and Medicine Meeting 2011, Pacific Grove, California: American Society for Biochemistry and Molecular Biology, Inc.
  • Liu, C., Gebicki, J. (2010). Intracellular concentrations of GSH and ascorbate regulate the levels of oxidized proteins. Society for Free Radical Research (Australasia) 19th Annual Conference, Australia: Society for Free Radical Research.
  • Karimi Galougahi, K., Liu, C., Garcia, A., Hamilton, E., Figtree, G., Rasmussen, H. (2010). Orally administred metoprolol stimulates the cardiac Na+-K+ pump by decreasing baseline oxidative modification of its beta 1 pump subunit. European Society of Cardiology (ESC) Congress 2010, Stockholm, Sweden: European Society of Cardiology.
  • Liu, C., Figtree, G., Hamilton, E., Garcia, A., Chia, K., Rasmussen, H. (2009). Oxidative Modification of Caveolin 3-Protein Glutathionylation. Society for Free Radical Biology & Medicine 16th Annual Meeting, San Francisco, USA: Society for Free Radical Biology & Medicine.
  • Liu, C., Seow, J., Hamilton, E., Garcia, A., Figtree, G., Rasmussen, H. (2009). Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation in the heart. 57th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand (CSANZ) 2009, Australia: Cardiac Society of Australia and New Zealand.
  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2008). Angiotensin II inhibits the Na+-K+ pump via PKC independent activation of NAD(P)H oxidase. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Garcia, A., Bundgarrd, H., Hamilton, E., Liu, C., Chia, K., Figtree, G., Rasmussen, H. (2008). B3 adrenergic stimulation of Na+-K+ pump is mediated by NO-dependent deglutathionylation of the B1 pump subunit. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Hamilton, E., Garcia, A., Chia, K., Liu, C., Figtree, G., Rasmussen, H. (2008). cGMP compartmentalization accounts for the bi-phasic effect of ANP on the Na+-K+ pump in rabbit cardiac myocytes. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Chia, K., Hamilton, E., Garcia, A., Wang, D., Liu, C., Figtree, G., Rasmussen, H. (2008). Nitric–oxide dependent guanylyl cyclase modulates NAD(P)H oxidase to modify and regulate the Na+-K+ pump in rabbit ventricular myocytes. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Liu, C., Figtree, G., Hamilton, E., Garcia, A., White, C., Cornelius, F., Rasmussen, H. (2008). Oxidative signalling inhibits the cardiac Na+-K+ pump via glutathionylation. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.

2016

  • Galougahi, K., Liu, C., Garcia, A., Gentle, C., Fry, N., Hamilton, E., Hawkins, C., Figtree, G. (2016). Beta3 adrenergic stimulation restores nitric oxide/redox balance and enhances endothelial function in hyperglycemia. Journal of the American Heart Association, 5(2), 1-17. [More Information]
  • Garcia, A., Liu, C., Cornelius, F., Clarke, R., Rasmussen, H. (2016). Glutathionylation-dependence of Na+ -K+ -pump currents can mimic reduced subsarcolemmal Na+ diffusion. Biophysical Journal, 110(5), 1099-1109. [More Information]
  • Liu, C., Teh, R., Mozar, C., Baxter, R., Rasmussen, H. (2016). Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and y -radiation on Na+/K+-ATPase and cell survival. Breast Cancer Research and Treatment, 155(2), 203-213. [More Information]

2015

  • Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Figtree, G., Rasmussen, H. (2015). Beta3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade. American Journal of Physiology: Cell Physiology, 309(5), C286-C295. [More Information]
  • Chia, K., Liu, C., Hamilton, E., Garcia, A., Fry, N., Hannam, W., Figtree, G., Rasmussen, H. (2015). Stimulation of the cardiac myocyte NA+-K+ pump due to reversal of its constitutive oxidative inhibition. American Journal of Physiology: Cell Physiology, 309(4), C239-C250. [More Information]

2014

  • Liu, C. (2014). Oxidation Of Ascorbate By Protein Radicals. Saarbrucken: Scholars' Press.

2013

  • Grieve, S., Lonborg, J., Mazhar, J., Tan, T., Ho, E., Liu, C., Lay, W., Gill, A., Kuchel, P., Bhindi, R., Figtree, G. (2013). Cardiac magnetic resonance imaging of rapid VCAM-1 up-regulation in myocardial ischemia-reperfusion injury. European Biophysics Journal, 42(1), 61-70. [More Information]
  • Garcia, A., Fry, N., Karimi, K., Liu, C., Apell, H., Rasmussen, H., Clarke, R. (2013). Extracellular allosteric Na+ binding to the Na+, K+-ATPase in cardiac myocytes. Biophysical Journal, 105(12), 2695-2705. [More Information]
  • Liu, C., Galougahi, K., Weisbrod, R., Hansen, T., Ravaie, R., Nunez, A., Liu, Y., Fry, N., Garcia, A., Hamilton, E., Figtree, G., et al (2013). Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction. Free Radical Biology and Medicine, 65(2013), 563-572. [More Information]
  • Liu, C., Seow, J., Figtree, G., Rasmussen, H. (2013). Oxidative modification after sheep myocardial infarction-glutathionylation of the beta 1 subunit in cardiac Na+-K+ pump. Society for Free Radical Biology & Medicine 16th Annual Meeting, San Francisco, USA: Society for Free Radical Biology & Medicine.
  • Figtree, G., White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2013). PKA inhibits the Na+-K+ pump via PKC-dependent activation of NAD(P)H oxidase and is associated with oxidative modification of the β1 pump subunit in cardiac myocytes. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]

2012

  • Galougahi, K., Liu, C., Bundgaard, H., Rasmussen, H. (2012). Beta-Adrenergic Regulation of the Cardiac Na+-K+ ATPase Mediated by Oxidative Signaling. Trends In Cardiovascular Medicine, 22(4), 83-87. [More Information]
  • Liu, C., Fry, N., Karimi Galougahi, K., Rasmussen, H., Figtree, G. (2012). Glutathionylation of Erythrocyte Na-K Pump in Heart Failure: A Novel Biomarker That Reflects a Key Oxidative Abnormality In the Heart. American Heart Association Scientific Sessions, Not published: Not Published.
  • Liu, C., Gebicki, J. (2012). Intracellular GSH and ascorbate inhibit radical-induced protein chain peroxidation in HL-60 cells. Free Radical Biology and Medicine, 52(2), 420-426. [More Information]
  • Liu, C., Armstrong, N., Figtree, G., Rasmussen, H. (2012). Oxidative inhibition of erythrocyte Na+-K+ pump in diabetes: a functionally relevant circulating marker of oxidative stress. 3rd International Workshop on Expression, Structure and Function of Membrane Proteins, Florence, Italy: Societa Italiana di Farmacologia.
  • Figtree, G., Galougahi, K., Liu, C., Rasmussen, H. (2012). Oxidative regulation of the Na+ -K+ pump in the cardiovascular system. Free Radical Biology and Medicine, 53(12), 2263-2268. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]

2011

  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]
  • Liu, C., Cornelius, F., Clarke, R., Rasmussen, H. (2011). Oxidant-induced glutathionylation of Na+-K+ ATPase: dependent on the Conformational states? Na, K-ATPase and Related P-ATPase: Structure, Biology and Medicine Meeting 2011, Pacific Grove, California: American Society for Biochemistry and Molecular Biology, Inc.

2010

  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Liu, C., Gebicki, J. (2010). Intracellular concentrations of GSH and ascorbate regulate the levels of oxidized proteins. Society for Free Radical Research (Australasia) 19th Annual Conference, Australia: Society for Free Radical Research.
  • Karimi Galougahi, K., Liu, C., Garcia, A., Hamilton, E., Figtree, G., Rasmussen, H. (2010). Orally administred metoprolol stimulates the cardiac Na+-K+ pump by decreasing baseline oxidative modification of its beta 1 pump subunit. European Society of Cardiology (ESC) Congress 2010, Stockholm, Sweden: European Society of Cardiology.
  • Rasmussen, H., Liu, C., Figtree, G. (2010). Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology. Trends In Cardiovascular Medicine, 20(3), 85-90. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]

2009

  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Liu, C., Figtree, G., Hamilton, E., Garcia, A., Chia, K., Rasmussen, H. (2009). Oxidative Modification of Caveolin 3-Protein Glutathionylation. Society for Free Radical Biology & Medicine 16th Annual Meeting, San Francisco, USA: Society for Free Radical Biology & Medicine.
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]
  • Liu, C., Seow, J., Hamilton, E., Garcia, A., Figtree, G., Rasmussen, H. (2009). Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation in the heart. 57th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand (CSANZ) 2009, Australia: Cardiac Society of Australia and New Zealand.

2008

  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2008). Angiotensin II inhibits the Na+-K+ pump via PKC independent activation of NAD(P)H oxidase. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Garcia, A., Bundgarrd, H., Hamilton, E., Liu, C., Chia, K., Figtree, G., Rasmussen, H. (2008). B3 adrenergic stimulation of Na+-K+ pump is mediated by NO-dependent deglutathionylation of the B1 pump subunit. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Hamilton, E., Garcia, A., Chia, K., Liu, C., Figtree, G., Rasmussen, H. (2008). cGMP compartmentalization accounts for the bi-phasic effect of ANP on the Na+-K+ pump in rabbit cardiac myocytes. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Chia, K., Hamilton, E., Garcia, A., Wang, D., Liu, C., Figtree, G., Rasmussen, H. (2008). Nitric–oxide dependent guanylyl cyclase modulates NAD(P)H oxidase to modify and regulate the Na+-K+ pump in rabbit ventricular myocytes. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • Liu, C., Figtree, G., Hamilton, E., Garcia, A., White, C., Cornelius, F., Rasmussen, H. (2008). Oxidative signalling inhibits the cardiac Na+-K+ pump via glutathionylation. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.

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