Dr Christopher Jolly

Research Fellow
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone 02 95656188
Fax 02 9565 6101

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Biographical details

PhD: Macquarie University/CSIRO, Sydney - 1993

Postdoctoral Fellow, John Curtin School of Medical Research, ANU, Canberra - 1993-1994 Postdoctoral Fellow: MRC Laboratory of Molecular Biology, Cambridge, UK - 1995-1997 Group Leader, Centenary Institute, Sydney - 1998-present

Research interests

My group studies antibody mutation in activated B cells, which is initiated by the DNA editing enzyme "AID". B cells mutate their antibody genes at extremely high rates during infections, to rapidly optimise the ability of the antibodies they make to neutralise the infecting pathogen. "Off-target" mutation of oncogenes by AID underlies most adult B cell cancers, so we seek to understand why AID-induced DNA damage leads to mutation, when similar DNA damage is generally repaired faithfully.

Teaching and supervision

B cell development. Antibody gene rearrangement and mutation.

Selected grants

2014

  • Protease therapies for diabetes-associated liver disease; Gorrell M, Keane F, Cook A, Shackel N, Seth D, Chen J, Jolly C, Hare N, McCaughan G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Cell divisions influence on antibody-mediated immunity; Jolly C, Cook A; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas de St Groth B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Activation and suppression of oncogenic translocation by uracil-DNA glycosylases; Jolly C, Holst J, Franklin A; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Regulation of the quality of DNA repair by timing in the cell cycle; Jolly C; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Understanding AID-induced cancer: Unravelling complex mutation and repair pathways; Jolly C; Cancer Council New South Wales/Research Project Grants.

2008

  • Antibody mutation promotes translocation: a natural cause of cancer; Jolly C, Manis J, Alt F; National Health and Medical Research Council (NHMRC)/Project Grants.
  • AID-induced DNA damage: DNA repair and the cell cycle; Jolly C; University of Sydney/Bridging Support.

2004

  • Production of human monoclonal antibodies in vivo; Jolly C; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

2001

  • Cell division and the regulation of immunoglobulin switch recombination at the molecular level; Jolly C, Hodgkin P, Hasbold J; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Sharbeen, G., Yee, C., Smith, A., Jolly, C. (2012). Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. The Journal of Experimental Medicine, 209(5), 965-974. [More Information]
  • Chan, T., Wood, K., Hermes, J., Butt, D., Jolly, C., Basten, A., Brink, R. (2012). Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen. Immunity, 37(5), 893-904. [More Information]
  • Sharbeen, G., Cook, A., Lau, K., Raftery, J., Yee, C., Jolly, C. (2010). Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo. Nucleic Acids Research, 38(22), 8120-8130. [More Information]
  • Jolly, C., Cook, A., Manis, J. (2008). Fixing DNA breaks during class switch recombination. The Journal of Experimental Medicine, 205(3), 509-513. [More Information]
  • Cook, A., Raftery, J., Lau, K., Jessup, A., Harris, R., Takeda, S., Jolly, C. (2007). DNA-Dependent Protein Kinase Inhibits AID-Induced Antibody Gene Conversion. PLoS Biology, 5(4), 1-8. [More Information]
  • Jolly, C., Cook, A., Raftery, J., Jones, M. (2007). Measuring bidirectional mutation. Journal of Theoretical Biology, 246, 267-277. [More Information]
  • Cook, A., Oganesian, L., Harumal, P., Basten, A., Brink, R., Jolly, C. (2003). Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. Journal of Immunology, 171(2003), 6456-6464.

2012

  • Sharbeen, G., Yee, C., Smith, A., Jolly, C. (2012). Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. The Journal of Experimental Medicine, 209(5), 965-974. [More Information]
  • Chan, T., Wood, K., Hermes, J., Butt, D., Jolly, C., Basten, A., Brink, R. (2012). Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen. Immunity, 37(5), 893-904. [More Information]

2010

  • Sharbeen, G., Cook, A., Lau, K., Raftery, J., Yee, C., Jolly, C. (2010). Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo. Nucleic Acids Research, 38(22), 8120-8130. [More Information]

2008

  • Jolly, C., Cook, A., Manis, J. (2008). Fixing DNA breaks during class switch recombination. The Journal of Experimental Medicine, 205(3), 509-513. [More Information]

2007

  • Cook, A., Raftery, J., Lau, K., Jessup, A., Harris, R., Takeda, S., Jolly, C. (2007). DNA-Dependent Protein Kinase Inhibits AID-Induced Antibody Gene Conversion. PLoS Biology, 5(4), 1-8. [More Information]
  • Jolly, C., Cook, A., Raftery, J., Jones, M. (2007). Measuring bidirectional mutation. Journal of Theoretical Biology, 246, 267-277. [More Information]

2003

  • Cook, A., Oganesian, L., Harumal, P., Basten, A., Brink, R., Jolly, C. (2003). Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. Journal of Immunology, 171(2003), 6456-6464.

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