Professor Christopher O'Neill

Professor
Medicine, Northern Clinical School

Telephone +61 2 9926 4870
Fax +61 2 9926 6343

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Research interests

The molecular and celluar regulation of fertility and early embryo development, the formation and uses of pluripotent stem cells, and the molecular basis of epigenetics.

Selected grants

2014

  • Epigenetic reprogramming within the pluripotent lineage of the early embryo; O'Neill C; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • IncuCyte FLR Microscope System and Cell Incubator; Baxter R, Marsh D, Jackson C, O'Neill C, Ashton A, Howell V; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
  • Epigenetic reprograming after fertilization; O'Neill C, Li Y; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Long term consequences of perturbing early embryo development; O'Neill C; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • The role of transciption factors in regulating the first round of gene expression in the early embryo; O'Neill C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms of p53 induced embryopathy after in vitro fertilisation; O'Neill C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of active demethylation in maintaining the differentiation status of cells; Morgan H, O'Neill C; Cure Cancer Australia Foundation/Research Support.

2007

  • Linkage 2006.2 - for funding commencing July 2007 -Development of a non-invasive diagnostic test of Embryo Viability; O'Neill C.
  • Development of a non invasive diagnostic test of Embryo Viability; O'Neill C; Australian Research Council (ARC)/Linkage Projects (LP).

2005

  • Role of tumour suppressor genes in early embryopathy; O'Neill C, Stojanov T; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Characterisation of signal transduction pathways in the early embryo; O'Neill C; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Functional genomic analysis of the role of p53 in early embryo death after assisted reproductive technologies (ART); O'Neill C; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • The role of PAF in the establishment of pregnancy; O'Neill C, Reiner O; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • O'Neill, C. (2011). Analysis of embryo-derived factors as markers of developmental potential and viability. In D. K. Gardner, B. R. M. B. Rizk & T. Falcone (Eds.), Human assisted reproductive technology: future trends in laboratory and clinical practice, (pp. 278-288). Cambridge: Cambridge University Press.

Journals

  • Fenelon, J., Shaw, G., O'Neill, C., Frankenberg, S., Renfree, M. (2014). Paf receptor expression in the marsupial embryo and endometrium during embryonic diapause. Reproduction, 147(1), 21-31. [More Information]
  • Li, Y., O'Neill, C. (2013). 5'-methylcytosine and 5'-hydroxymethylcytosine Each Provide Epigenetic Information to the Mouse Zygote. PLoS One, 8(5), 1-9. [More Information]
  • O'Neill, C. (2013). Lessons from zebrafish on reprogramming the epigenetic code after fertilisation. Asian Journal of Andrology, 15(5), 582-583. [More Information]
  • Li, Y., O'Neill, C. (2012). Persistence of Cytosine Methylation of DNA following Fertilisation in the Mouse. PLoS One, 7(1), 1-11. [More Information]
  • Vasica, G., O'Neill, C., Sidhu, S., Sywak, M., Reeve, T., Delbridge, L. (2012). Reoperative surgery for bilateral multinodular goitre in the era of total thyroidectomy. British Journal of Surgery, 99(5), 688-692. [More Information]
  • O'Neill, C., Li, Y., Jin, X. (2012). Survival signaling in the preimplantation embryo. Theriogenology: an international journal of animal reproduction, 77(4), 773-784. [More Information]
  • Li, A., Ganeshan, L., O'Neill, C. (2012). The Effect of Trp53 Gene-Dosage and Parent-of-Origin of Inheritance on Mouse Gamete and Embryo Function In Vitro. Biology of Reproduction, 86(6), 1-6. [More Information]
  • Gao, S., Jack, M., O'Neill, C. (2012). Towards Optimising the Production of and Expression from Polycistronic Vectors in Embryonic Stem Cells. PLoS One, 7(11), 1-13. [More Information]
  • Mu, X., Jin, X., Farnham, M., Li, Y., O'Neill, C. (2011). DNA Damage-Sensing Kinases Mediate the Mouse 2-Cell Embryo's Response to Genotoxic Stress. Biology Of Reproduction, 85(3), 524-535. [More Information]
  • Jin, X., O'Neill, C. (2011). Regulation of the Expression of Proto-Oncogenes by Autocrine Embryotropins in the Early Mouse Embryo. Biology Of Reproduction, 84(6), 1216-1224. [More Information]
  • Beardsley, A., Li, Y., O'Neill, C. (2010). Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro. Reproductive Biology and Endocrinology, 8(71), 1-10. [More Information]
  • Jin, X., O'Neill, C. (2010). The Presence and Activation of Two Essential Transcription Factors (cAMP Response Element-Binding Protein and cAMP-Dependent Transcription Factor ATF1) in the Two-Cell Mouse Embryo. Biology Of Reproduction, 82(2), 459-468. [More Information]
  • Ganeshan, L., Li, A., O'Neill, C. (2010). Transformation-related protein 53 expression in the early mouse embryo compromises preimplantation embryonic development by preventing the formation of a proliferating inner cell mass. Biology Of Reproduction, 83(6), 958-964. [More Information]
  • Li, Y., O'Neill, C., Day, M. (2009). Activation of a Chloride Channel by a Trophic Ligand Is Required for Development of the Mouse Preimplantation Embryo In Vitro. Biology Of Reproduction, 81(4), 759-767. [More Information]
  • Jin, X., Chandrakanthan, V., Morgan, H., O'Neill, C. (2009). Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway. Biology Of Reproduction, 80(2), 286-294. [More Information]
  • O'Neill, C. (2008). Phosphatidylinositol 3-kinase signaling in mammalian preimplantation embryo development. Reproduction, 136(2), 147-156. [More Information]
  • Morgan, H., Jin, X., Li, A., Whitelaw, E., O'Neill, C. (2008). The culture of zygotes to the blastocyst stage changes the postnatal expression of an epigentically labile allele, agouti viable yellow, in mice. Biology Of Reproduction, 79(4), 618-623. [More Information]
  • O'Neill, C. (2008). The potential roles for embryotrophic ligands in preimplantation embryo development. Human Reproduction Update, 14(3), 275-288. [More Information]
  • Mahsoudi, B., Li, A., O'Neill, C. (2007). Assessment of the long-term and transgenerational consequences of perturbing preimplantation embryo development in mice. Biology Of Reproduction, 77(5), 889-896. [More Information]
  • Li, Y., Day, M., O'Neill, C. (2007). Autocrine activation of ion currents in the two-cell mouse embryo. Experimental Cell Research: emphasizing molecular approaches to cell biology, 313(13), 2786-2794. [More Information]
  • Jin, X., O'Neill, C. (2007). cAMP-responsive element-binding protein expression and regulation in the mouse preimplantation embryo. Reproduction, Fertility and Development, 134(5), 667-675. [More Information]
  • Li, A., Chandrakanthan, V., Chami, O., O'Neill, C. (2007). Culture of zygotes increases p53 expression in B6 mouse embryos, which reduces embryo viability. Biology Of Reproduction, 76(3), 362-367. [More Information]
  • Li, Y., Chandrakanthan, V., Day, M., O'Neill, C. (2007). Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. Biology Of Reproduction, 77(5), 813-821. [More Information]
  • Chandrakanthan, V., Chami, O., Stojanov, T., O'Neill, C. (2007). Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts. Reproductive Biology and Endocrinology, 5(17 October 2007), 39- 1-39 - 6. [More Information]
  • Chandrakanthan, V., Li, A., Chami, O., O'Neill, C. (2006). Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos. Reproductive Biology and Endocrinology, 4(1), 61-61. [More Information]
  • O'Neill, C. (2005). The role of paf in embryo physiology. Human Reproduction Update, 11(3), 215-228.
  • Chami, O., Evans, G., O'Neill, C. (2004). Components Of A Platelet-Activating Factor-Signaling Loop Are Assembled In The Ovine Endometrium Late In The Estrous Cycle. American Journal of Physiology: Endocrinology and Metabolism, 287(2), E233-E240.
  • Lu, D., Chandrakanthan, V., Cahana, A., Ishii, S., O'Neill, C. (2004). Trophic Signals Acting Via Phosphatidylinositol-3 Kinase Are Required For Normal Pre-Implantation Mouse Embryo Development. Journal of Cell Science, 117(8), 1567-1576.
  • Cahana, A., Jin, X., Reiner, O., Wynshaw-Boris, A., O'Neill, C. (2003). A study of the nature of embryonic lethality in LIS1-I- mice. Molecular Reproduction and Development, 66(2), 134-142. [More Information]
  • Lu, D., Li, Y., Bathgate, R., Day, M., O'Neill, C. (2003). Ligand-activated signal transduction in the 2-cell embryo. Biology Of Reproduction, 69(1), 106-116.
  • Stojanov, T., Chami, O., Li, A., O'Neill, C., Wu, C., Ishi,, S., Shimuzu, T., Stocker, R. (2001). Evidence of the Autocrine induction of capacitation of mammalian spermatozoa. Journal of Biological Chemistry, 276, 26962-26968.
  • O'Neill, C., Stojanov, T. (2001). In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. Biology Of Reproduction, 64, 696-705.

Patents

  • O'Neill, C. (2010). Methods of Assessing Embryo Viability. Patent No. 1847595, 602007004143. Germany.

2014

  • Fenelon, J., Shaw, G., O'Neill, C., Frankenberg, S., Renfree, M. (2014). Paf receptor expression in the marsupial embryo and endometrium during embryonic diapause. Reproduction, 147(1), 21-31. [More Information]

2013

  • Li, Y., O'Neill, C. (2013). 5'-methylcytosine and 5'-hydroxymethylcytosine Each Provide Epigenetic Information to the Mouse Zygote. PLoS One, 8(5), 1-9. [More Information]
  • O'Neill, C. (2013). Lessons from zebrafish on reprogramming the epigenetic code after fertilisation. Asian Journal of Andrology, 15(5), 582-583. [More Information]

2012

  • Li, Y., O'Neill, C. (2012). Persistence of Cytosine Methylation of DNA following Fertilisation in the Mouse. PLoS One, 7(1), 1-11. [More Information]
  • Vasica, G., O'Neill, C., Sidhu, S., Sywak, M., Reeve, T., Delbridge, L. (2012). Reoperative surgery for bilateral multinodular goitre in the era of total thyroidectomy. British Journal of Surgery, 99(5), 688-692. [More Information]
  • O'Neill, C., Li, Y., Jin, X. (2012). Survival signaling in the preimplantation embryo. Theriogenology: an international journal of animal reproduction, 77(4), 773-784. [More Information]
  • Li, A., Ganeshan, L., O'Neill, C. (2012). The Effect of Trp53 Gene-Dosage and Parent-of-Origin of Inheritance on Mouse Gamete and Embryo Function In Vitro. Biology of Reproduction, 86(6), 1-6. [More Information]
  • Gao, S., Jack, M., O'Neill, C. (2012). Towards Optimising the Production of and Expression from Polycistronic Vectors in Embryonic Stem Cells. PLoS One, 7(11), 1-13. [More Information]

2011

  • O'Neill, C. (2011). Analysis of embryo-derived factors as markers of developmental potential and viability. In D. K. Gardner, B. R. M. B. Rizk & T. Falcone (Eds.), Human assisted reproductive technology: future trends in laboratory and clinical practice, (pp. 278-288). Cambridge: Cambridge University Press.
  • Mu, X., Jin, X., Farnham, M., Li, Y., O'Neill, C. (2011). DNA Damage-Sensing Kinases Mediate the Mouse 2-Cell Embryo's Response to Genotoxic Stress. Biology Of Reproduction, 85(3), 524-535. [More Information]
  • Jin, X., O'Neill, C. (2011). Regulation of the Expression of Proto-Oncogenes by Autocrine Embryotropins in the Early Mouse Embryo. Biology Of Reproduction, 84(6), 1216-1224. [More Information]

2010

  • Beardsley, A., Li, Y., O'Neill, C. (2010). Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro. Reproductive Biology and Endocrinology, 8(71), 1-10. [More Information]
  • O'Neill, C. (2010). Methods of Assessing Embryo Viability. Patent No. 1847595, 602007004143. Germany.
  • Jin, X., O'Neill, C. (2010). The Presence and Activation of Two Essential Transcription Factors (cAMP Response Element-Binding Protein and cAMP-Dependent Transcription Factor ATF1) in the Two-Cell Mouse Embryo. Biology Of Reproduction, 82(2), 459-468. [More Information]
  • Ganeshan, L., Li, A., O'Neill, C. (2010). Transformation-related protein 53 expression in the early mouse embryo compromises preimplantation embryonic development by preventing the formation of a proliferating inner cell mass. Biology Of Reproduction, 83(6), 958-964. [More Information]

2009

  • Li, Y., O'Neill, C., Day, M. (2009). Activation of a Chloride Channel by a Trophic Ligand Is Required for Development of the Mouse Preimplantation Embryo In Vitro. Biology Of Reproduction, 81(4), 759-767. [More Information]
  • Jin, X., Chandrakanthan, V., Morgan, H., O'Neill, C. (2009). Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway. Biology Of Reproduction, 80(2), 286-294. [More Information]

2008

  • O'Neill, C. (2008). Phosphatidylinositol 3-kinase signaling in mammalian preimplantation embryo development. Reproduction, 136(2), 147-156. [More Information]
  • Morgan, H., Jin, X., Li, A., Whitelaw, E., O'Neill, C. (2008). The culture of zygotes to the blastocyst stage changes the postnatal expression of an epigentically labile allele, agouti viable yellow, in mice. Biology Of Reproduction, 79(4), 618-623. [More Information]
  • O'Neill, C. (2008). The potential roles for embryotrophic ligands in preimplantation embryo development. Human Reproduction Update, 14(3), 275-288. [More Information]

2007

  • Mahsoudi, B., Li, A., O'Neill, C. (2007). Assessment of the long-term and transgenerational consequences of perturbing preimplantation embryo development in mice. Biology Of Reproduction, 77(5), 889-896. [More Information]
  • Li, Y., Day, M., O'Neill, C. (2007). Autocrine activation of ion currents in the two-cell mouse embryo. Experimental Cell Research: emphasizing molecular approaches to cell biology, 313(13), 2786-2794. [More Information]
  • Jin, X., O'Neill, C. (2007). cAMP-responsive element-binding protein expression and regulation in the mouse preimplantation embryo. Reproduction, Fertility and Development, 134(5), 667-675. [More Information]
  • Li, A., Chandrakanthan, V., Chami, O., O'Neill, C. (2007). Culture of zygotes increases p53 expression in B6 mouse embryos, which reduces embryo viability. Biology Of Reproduction, 76(3), 362-367. [More Information]
  • Li, Y., Chandrakanthan, V., Day, M., O'Neill, C. (2007). Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. Biology Of Reproduction, 77(5), 813-821. [More Information]
  • Chandrakanthan, V., Chami, O., Stojanov, T., O'Neill, C. (2007). Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts. Reproductive Biology and Endocrinology, 5(17 October 2007), 39- 1-39 - 6. [More Information]

2006

  • Chandrakanthan, V., Li, A., Chami, O., O'Neill, C. (2006). Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos. Reproductive Biology and Endocrinology, 4(1), 61-61. [More Information]

2005

  • O'Neill, C. (2005). The role of paf in embryo physiology. Human Reproduction Update, 11(3), 215-228.

2004

  • Chami, O., Evans, G., O'Neill, C. (2004). Components Of A Platelet-Activating Factor-Signaling Loop Are Assembled In The Ovine Endometrium Late In The Estrous Cycle. American Journal of Physiology: Endocrinology and Metabolism, 287(2), E233-E240.
  • Lu, D., Chandrakanthan, V., Cahana, A., Ishii, S., O'Neill, C. (2004). Trophic Signals Acting Via Phosphatidylinositol-3 Kinase Are Required For Normal Pre-Implantation Mouse Embryo Development. Journal of Cell Science, 117(8), 1567-1576.

2003

  • Cahana, A., Jin, X., Reiner, O., Wynshaw-Boris, A., O'Neill, C. (2003). A study of the nature of embryonic lethality in LIS1-I- mice. Molecular Reproduction and Development, 66(2), 134-142. [More Information]
  • Lu, D., Li, Y., Bathgate, R., Day, M., O'Neill, C. (2003). Ligand-activated signal transduction in the 2-cell embryo. Biology Of Reproduction, 69(1), 106-116.

2001

  • Stojanov, T., Chami, O., Li, A., O'Neill, C., Wu, C., Ishi,, S., Shimuzu, T., Stocker, R. (2001). Evidence of the Autocrine induction of capacitation of mammalian spermatozoa. Journal of Biological Chemistry, 276, 26962-26968.
  • O'Neill, C., Stojanov, T. (2001). In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. Biology Of Reproduction, 64, 696-705.

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