Professor Chris Liddle
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Professor of Clinical Pharmacology & Hepatology
C24 - Westmead Hospital |
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Research interests
Over the past decade Chris' main area of research has been in the functional genomics of human drug metabolism and adaptive responses to toxic xenobiotic (foreign) and endobiotic (endogenous) chemical compounds. An extension of this work is to understand how the liver protects itself from toxic damage, as occurs in liver diseases where the flow of bile is obstructed (cholestatic liver diseases). More recent work has focused on the role of nuclear hormone receptors in hepatic fibrogenesis, particularly the role of the Vitamin D Receptor as a therapeutic target to prevent progression to cirrhosis in patients with chronic liver disease. These research projects have resulted in three patent families, two of which have been commercialized, as well as several highly cited publications.
Chris also has an interest in advanced information technology systems in the fields of biomedical research and clinical medicine. He is presently working on the bioinformatics of Next-Gen DNA sequencing technologies (e.g.; ChIP-Seq and RNA-Seq) and is Associate Dean for Information Technology Development within the Sydney Medical School.
Teaching areas
Clinical Pharmacology, Drug Metabolism, Liver Diseases
Current national competitive grants*
2012
A Multi-site study of Tamoxifen dose escalation study in breast cancer patients with CYP2D6 polymorphisms (TADE study)
Gurney H, Balleine R, Wilcken N, Liddle C
NHMRC Project Grants ($329,901 over 3 years)
2010
Steroidogenic factor-1, a novel regulator of hepatic stellate cell function
Liddle C, Downes M
NHMRC Project Grant ($568,500 over 3 years)
* Grants administered through the University of Sydney
International links
United States. (Genentec Inc., San Francisco, CA.) Collaboration, Hepatic Gene Regulation.
Belgium. (Catholic University, Leuven.) Collaboration, Bile Acids in Critically Ill Patients.
United States. (Deltagen Inc., San Mateo, CA.) IP Licensee, Tools for Drug Screening..
Netherlands. (Academic Medical Center, Amsterdam.) Collaboration, Pharmacogenomics of Cancer Chemotherapy.
Netherlands. (University Medical Center, Groningen.) Collaboration, Hepatocyte Transporters..
United States. (Salk Institute for Biological Studies, La Jolla, CA.) Adjunct Professor (appointed 2010).