Professor Christopher Little

Director Raymond Purves Bone and Joint Research Labs
Surgery, Northern Clinical School
Kolling Institute of Medical Research

Telephone 02 9926 4800
Fax 02 9926 5266

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Biographical details

Professor Christopher Little is director of the Raymond Purves Bone and Joint Research Labs at the Kolling Institute of Medical Research at Royal North Shore Hospital, Australia. Chris is a qualified Veterinarian with specialist surgery training and ACVS certification. He was awarded a PhD degree from the University of Sydney in 1996 for his studies of cartilage degradation in a sheep model of osteoarthritis (OA). Following a 5-year postdoctoral position at Cardiff University (UK), he was awarded an Arthritis Foundation of Australia Fellowship at the University of Melbourne. In 2004 he moved to his current position in the University of Sydney Faculty of Medicine. Chris's research interests focus on defining the biochemical and molecular mechanisms of joint pathology in OA, and tendon and intervertebral disc degeneration, and are based on the belief that it is only though a better understanding the mechanisms that drive the initiation and progression of these diseases that new therapies can be developed. Chris is recognized internationally for his expertise in the development and use of animal models of bone and joint disease. He has served as an Associate Editor of Osteoarthritis and Cartilage, and a leader of the OARSI international initiative to establish standardised methods for evaluation of animal models of OA. Chris received the 2010 Barry Preston Award from the Matrix Biology Society of Australia and New Zealand, presented to an outstanding leader in the field. He has authored/co-authored 104 scientific papers and 7 book chapters.

Selected grants

2015

  • Investigating osteoarthritis following different injury mechanisms; Blaker C, Little C, Clarke E; Arthritis Australia/Grants-in-Aid.

2014

  • Molecular mechanisms of joint degeneration in osteoarthritis; Bateman J, Little C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Cell therapies for tendon disease; Little C; DVC Research/Bridging Support Grant.

2013

  • The diabetic hand - understanding the mechanisms of tendinopathy; Smith M, Little C; Lincoln Centre for Research into Bone & Joint Diseases/Research Support.
  • Serum microRNA biomarkers of osteoarthritis; Little C, Bateman J, Sonnabend D; Australian Orthopaedic Association Research Foundation Ltd/Research Grant.
  • Synovial macrophages and T-cells are therapeutic targets in osteoarthritis; Little C, Hunter D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Investigating the pain mechanisms in osteoarthritis; Zaki S, Little C, Connor M; Arthritis Australia/Grants-in-Aid.

2012

  • Purves Visiting Professor - Professor Stefan Lohmander; Little C, Hunter D; Raymond E Purves Foundation/Research Grant.
  • Sclerostin Is A Key Regulator Of Wnt Signalling In Bone And Cartilage Pathology In Osteoarthritis; Little C, Sambrook P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The calcium channel TRPV4 in skeletal development and arthritis; Little C, McIntyre P, Lamande S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Nano-mechanical and nano-structural investigation of dentine: unravelling a novel nano-scale regulator of high durability of mineralized tissues.; Swain M, Little C; Australian Research Council (ARC)/Discovery Projects (DP).

2011

  • Fluorescent microscopy of bone and joint tissues; Little C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Inflammation in post-traumatic osteoarthritis; Little C; Arthritis Australia/Grants-in-Aid.
  • Mesenchymal Progenitor cells and intervertebral disc repair; Melrose J, Appleyard R, Little C; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Studies of endogenous stem cells in tendon; Little C; Arthritis Australia/Grants-in-Aid.
  • Studies of endogenous stem cells in tendon; Little C; Perpetual Trustees Charitable Trusts/Research Support.
  • Cellular mechanisms in chondroid degeneration of tendon; Little C, Sonnabend D, Smith M; Australian Orthopaedic Association Research Foundation Ltd/Research Support.
  • Bone-specific sclerostin and SIBLING proteins in osteoarthritis: novel contributions to cartilage and bone pathology; Little C, Sambrook P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • MMI Smart Cut Plus laser microdissector; Baxter R, Little C, Marsh D, Keast J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Research-Laboratory consumables; Little C; University of Liverpool/Research Support.

2009

  • Histology and immunohistology of large bone and joint tissue specimens; Little C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Biochemical Analysis of Samples for the Mesoblast Proj; Little C; Institute of Medical and Veterinary Science/Research Support.
  • Stem Cell treatment for tendon degeneration; Smith M, Little C, Smith M, Sonnabend D, Appleyard R, Melrose J, Hunyor S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis; Little C, Jackson C; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • An in-vitro model of meniscal degeneration initiated by inflammatory cytokines; Melrose J, Little C; Arthritis Foundation of Australia/Research Support.
  • The role of perlacan in tensional connective tissues; Melrose J, Whitelock J, Hayes A, Whitelock J, Appleyard R, Little C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Activated protein C and protease activated receptors (PARs) in cartilage degradation mechanisms in osteoarthritis; Little C; University of Sydney/Bridging Support.

2007

  • Metalloproteinase activation in cartilage remodeling; Little C; University of Sydney/Bridging Support.

2006

  • INSTRON 8874 Multi-axis Testing System; Little C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Evaluation of four genetically modified mice using a medial meniscal destabilization model of osteoarthritis (MMD induced OA); Little C; Pfizer Inc/Research Grants.
  • Biomechanical testing to detect cartilage breakdown; Little C; Arthritis Foundation of Australia/Grants-In-Aid and Special Purpose Grants.
  • Proteoglycan metabolism in tendon degeneration; Little C, Sonnabend D, Appleyard R, Melrose J, Fosang A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • How important is collagen destruction in arthritis?; Little C, Fosang A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms of cartilage breakdown in osteoarthritis.; Bateman J, Little C, Fosang A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Investigating the role of activated protein C (APC) in biochemical and biomechanical degeneration of cartilage in arthritis; Appleyard R, Little C; Royal North Shore Hospital/Area Research Grants.
  • RotorGene 6000 real-time PCR; Little C; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2005

  • Discovering which enzymes are important in joint disease.; Little C, Fosang A, Stanton H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Evaluation and validation of medical Destabilization in mice as a model of Osteoarthritis.; Little C, Lanfear J; Pfizer Inc/Pfizer Pty Ltd.
  • Inverted Fluorescence Microscopy: A sensitive method used to visualise protein expression in live cells; Jackson C, Davey R, Little C, Morris J, Gallery E; BLO DETYA National School Drug Education Strategy/RIGB Grant.
  • Testing CSIRO compounds PDS-1 and DS in collagen-induced arthritis in mice; Little C, Haaima G; CSIRO/Livestock Industries.
  • Defining mechanisms of cartilage breakdown in arthritis; Little C; Arthritis Research Taskforce/Ulysses Arthritis Research Taskforce Fellowship.
  • Pathobiology of the small leucine rich repeat proteoglycans in cartilage, intervertebral disc and tendon degeneration; Melrose J, Little C, Sonnabend D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Investigation of the disease mechanisms in osteoarthritis; Little C; Rebecca L Cooper Medical Research Foundation/Research Grant.
  • The role of aggrecan turnover in tendon pathology.; Little C, Sonnabend D, Smith M, Appleyard R; Australian Orthopaedic Association Research Foundation Ltd/Research Grant.

2004

  • Biomechanical and biochemical mechanisms of tendon homeostasis in normal, pathological and post-operative states.; Little C, Dart A, Sonnabend D, Appleyard R, Smith M; Australian Orthopaedic Association Research Foundation Ltd/Research Grant.
  • The role of cathepsin K in musculoskeletal disorders: potential modulation by pentosan polysulphate.; Little C, Smith M, Melrose J; Sylvan Pharmaceuticals Pty Ltd/Research Grant.
  • Laboratory studies on articular cartilage and synovium to evaluate the effects of intra-articular treatments of hyaluronan (Hyalgan-E, Hyalgan-F and /or HYADD4) in an ovine model of osteoarthritis.; Little C, Smith M, Melrose J; FIDIA Pharmaceuticals/Research Grant.

2003

  • Development of antibodies to investigate the mechanisms of aggrecan catabolism in development, growth and disease; Little C; University of Melbourne/Early Career Researcher Development Award.

2002

  • The role of aggrecanase and MMPs in the initiation and progression of arthritis using proteinase resistant knock-in mice; Little C; Arthritis Research Taskforce/Ulysses Arthritis Research Taskforce Fellowship.

2001

  • Mechanisms of matrix proteoglycan catabolism in articular cartilage; Hughes C, Little C, Caterson B; Arthritis Research Taskforce/Arthritis Research Campaign (UK).

1999

  • Catabolism of the collagen-associated leucine-rich repeat proteoglycans in articular cartilage degeneration; Little C, Caterson B; Arthritis Research Taskforce/Arthritis Research Campaign (UK).
  • Diagnosis and monitoring of joint pathology in the horse; Caterson B, Little C; Horse Trust (UK)/Home of Rest for Horses.

Selected publications

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Book Chapters

  • Smith, M., Little, C. (2007). Experimental Models of Osteoarthritis. In Moskowitz, Altman, Hochberg, Buckwalter & Glodberg (Eds.), Osteoarthritis: Diagnosis and Medical/ Surgical Management, (pp. 107-125). Philadelphia, USA: Lippincott Williams & Wilkins.
  • Hughes, C., Caterson, B., Little, C., Wright, S. (2004). Aggrecanases 1 and 2. In Woessner F, Alan J. Barrett, Neil D. Rawlings (Eds.), Handbook of Proteolytic Enzymes, (pp. 740-740). Canada: Academic Press.

Journals

  • Smith, R., McIlwraith, W., Schweitzer, R., Kadler, K., Cook, J., Caterson, B., Dakin, S., Heinegard, D., Screen, H., Stover, S., Little, C., et al (2014). Advances in the understanding of tendinopathies: a report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal, 46(11), 4-9. [More Information]
  • Hodges, P., James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J. (2014). Can Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion? Spine, 39(13), 1010-1017. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research & Therapy, 16(1), 1-12. [More Information]
  • Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 are activated by Activated Protein C (APC) in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatism, 66(6), 1525-1536. [More Information]
  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
  • Riordan, E., Little, C., Hunter, D. (2014). Pathogenesis of post-traumatic OA with a view to intervention. Best Practice & Research: Clinical Rheumatology, 28(1), 17-30. [More Information]
  • Koenig, T., Dart, A., McIlwraith, C., Horadagoda, N., Bell, R., Perkins, N., Dart, C., Krockenberger, M., Jeffcott, L., Little, C. (2014). Treatment of Experimentally Induced Osteoarthritis in Horses Using an Intravenous Combination of Sodium Pentosan Polysulfate, N-Acetyl Glucosamine, and Sodium Hyaluronan. Veterinary Surgery, 43(5), 612-622. [More Information]
  • Malfait, A., Little, C., Dougall, J. (2013). A commentary on modelling osteoarthritis pain in small animals. Osteoarthritis and Cartilage, 21(9), 1316-1326. [More Information]
  • Smith, M., Russell, A., Schiavinato, A., Little, C. (2013). A hexadecylamide derivative of hyaluronan (HYMOVIS(R)) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. Journal of Inflammation, 10(1), 1-16. [More Information]
  • Melrose, J., Smith, M., Smith, S., Ravi, V., Young, A., Dart, A., Sonnabend, D., Little, C. (2013). Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy. Tissue and Cell, 45(1), 77-82. [More Information]
  • Shu, C., Smith, S., Little, C., Melrose, J. (2013). Comparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic and osteogenic development of the human foetal spine. European Spine Journal, 22(8), 1774-1784. [More Information]
  • Cake, M., Read, R., Corfield, G., Daniel, A., Burkhardt, D., Smith, M., Little, C. (2013). Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Osteoarthritis and Cartilage, 21(1), 226-236. [More Information]
  • Smith, M., Ravi, V., Dart, A., Sonnabend, D., Little, C. (2013). Factors affecting tendinopathogenesis. British Journal of Sports Medicine, 47(9), 23-24. [More Information]
  • Smith, M., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47, 29-29.
  • Smith, M., Jacobson, E., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47(9), e2. [More Information]
  • Belluoccio, D., Rowley, L., Little, C., Bateman, J. (2013). Maintaining mRNA integrity during decalcification of mineralized tissues. PloS One, 8(3), 1-6. [More Information]
  • Little, C., Hunter, D. (2013). Post-traumatic osteoarthritis: from mouse models to clinical trials. Nature Reviews Rheumatology, 9(8), 485-497. [More Information]
  • Gossan, N., Zeef, L., Hensman, J., Hughes, A., Bateman, J., Rowley, L., Little, C., Piggins, H., Rattray, M., Boot-Handford, R., et al (2013). The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis. Arthritis & Rheumatism, 65(9), 2334-2345. [More Information]
  • Shu, C., Hughes, C., Smith, S., Smith, M., Hayes, A., Caterson, B., Little, C., Melrose, J. (2013). The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal, 30(7), 717-725. [More Information]
  • Bateman, J., Rowley, L., Belluoccio, D., Chan, B., Bell, K., Fosang, A., Little, C. (2013). Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction. Arthritis & Rheumatism, 65(6), 1547-1560. [More Information]
  • Maher, A., Coles, C., White, J., Bateman, J., Fuller, E., Burkhardt, D., Little, C., Cake, M., Read, R., McDonagh, M., et al (2012). 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep. Journal of Proteome Research, 11(8), 4261-4268. [More Information]
  • Melrose, J., Isaacs, M., Smith, S., Hughes, C., Little, C., Caterson, B., Hayes, A. (2012). Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology, 138(3), 461-475. [More Information]
  • Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012). Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine, 37(1), 18-25. [More Information]
  • Boeuf, S., Graf, F., Fischer, J., Moradi, B., Little, C., Richter, W. (2012). Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells. European Cells and Materials, 23, 320-332. [More Information]
  • Chan, B., Little, C. (2012). The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis. Arthritis Research & Therapy, 14(3), 119-1-119-3. [More Information]
  • Little, C., Zaki, S. (2012). What constitutes an "animal model of osteoarthritis" - the need for consensus ? Osteoarthritis and Cartilage, 20(4), 261-267. [More Information]
  • Little, C., Zaki, S. (2012). What constitutes an ‘animal model of osteoarthritis’ ¬ the need for consensus? Osteoarthritis and Cartilage, 20(4), 261-267. [More Information]
  • Fuller, E., Smith, M., Little, C., Melrose, J. (2012). Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthritis and Cartilage, 20(1), 49-59. [More Information]
  • Bernardo, B., Belluoccio, D., Rowley, L., Little, C., Hansen, U., Bateman, J. (2011). Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis. Journal of Biological Chemistry, 286(43), 37758-37767. [More Information]
  • Chan, B., Fuller, E., Russell, A., Smith, S., Smith, M., Jackson, M., Cake, M., Read, R., Bateman, J., Sambrook, P., Little, C. (2011). Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis and Cartilage, 19(7), 874-885. [More Information]
  • Stanton, H., Golub, S., Rogerson, F., Last, K., Little, C., Fosang, A. (2011). Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nature Protocols, 6(3), 388-404. [More Information]
  • Lamande, S., Yuan, Y., Gresshoff, I., Rowley, L., Belluoccio, D., Kaluarachchi, K., Little, C., Botzenhart, E., Zerres, K., Amor, D., et al (2011). Mutations in TRPV4 cause an inherited arthropathy of hands and feet. Nature Genetics, 43(11), 1142-1146. [More Information]
  • Stanton, H., Melrose, J., Little, C., Fosang, A. (2011). Proteoglycan degradation by the ADAMTS family of proteinases. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1812 (12), 1616-1629. [More Information]
  • Glasson, S., Little, C. (2011). The recent paper "Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity". Osteoarthritis and Cartilage, 19(8), 1076-1077. [More Information]
  • Schollum, M., Appleyard, R., Little, C., Melrose, J. (2010). A Detailed Microscopic Examination of Alterations in Normal Anular Structure Induced by Mechanical Destabilization in an Ovine Model of Disc Degeneration. Spine, 35(22), 1965-1973. [More Information]
  • Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
  • Aigner, T., Cook, J., Gerwin, N., Glasson, S., Laverty, S., Little, C., McIlwraith, W., Kraus, V. (2010). Histopathology atlas of animal model systems - overview of guiding principles. Osteoarthritis and Cartilage, 18(SUPPL. 3), S2-S6. [More Information]
  • Melrose, J., Little, C. (2010). Immunolocalization of lymphatic vessels in human fetal knee joint tissues. Connective Tissue Research, 51(4), 289-305. [More Information]
  • Little, C., Fosang, A. (2010). Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis - insights from studies of aggrecan and collagen proteolysis? Current Drug Targets, 11(5), 561-575. [More Information]
  • Fosang, A., Last, K., Stanton, H., Golub, S., Little, C., Brown, L., Jackson, D. (2010). Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan. Methods in Molecular Biology (Clifton N.J.), 622, 312-47. [More Information]
  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research & Therapy, 12(1), 1-13. [More Information]
  • Little, C., Kim, Y. (2010). Targeting Cartilage Breakdown in Osteoarthritis. Journal of American Academy of Orthopaedic Surgeons, 18(4), 243-246.
  • Little, C., Smith, M., Cake, M., Read, R., Murphy, M., Barry, F. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis and Cartilage, 18(Suppl 3), S80-S92. [More Information]
  • Little, C. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis and Cartilage, 18(3), S17-23. [More Information]
  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis and Rheumatism, 60(3), 780-791. [More Information]
  • Melrose, J., Burkhardt, D., Taylor, T., Dillon, C., Read, R., Cake, M., Little, C. (2009). Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease. European Spine Journal, 18(4), 479-489. [More Information]
  • Little, C., Barai, A., Burkhardt, D., Smith, S., Fosang, A., Werb, Z., Shah, M., Thompson, E. (2009). Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Care and Research, 60(12), 3723-3733. [More Information]
  • Smith, S., Whitelock, J., Iozzo, R., Little, C., Melrose, J. (2009). Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Histochemistry and Cell Biology, 132(5), 491-503. [More Information]
  • Little, C., Smith, M. (2008). Animal Models of Osteoarthritis. Current Rheumatology Reviews, 4(3), 175-182. [More Information]
  • Cake, M., Read, R., Edwards, S., Smith, M., Burkhardt, D., Little, C., Ghosh, P. (2008). Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. Journal of orthopaedic science, 13(6), 514-523. [More Information]
  • Fosang, A., Little, C. (2008). Drug insight: aggrecanases as therapeutic targets for osteoarthritis. Nature clinical practice: Rheumatology, 4(8), 420-427. [More Information]
  • Fitzgerald, J., Rich, C., Burkhardt, B., Allen, J., Herzka, A., Little, C. (2008). Evidence for articular cartilage regeneration in MRL/MpJ mice. Osteoarthritis and Cartilage, 16(11), 1319-1326. [More Information]
  • Melrose, J., Fuller, E., Roughley, P., Smith, M., Kerr, B., Hughes, C., Caterson, B., Little, C. (2008). Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Research & Therapy, 10(doi:10.1186/ar2453), 1-10. [More Information]
  • Gauci, S., Golub, S., Tutolo, L., Little, C., Sims, N., Lee, E., Mackie, E., Fosang, A. (2008). Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage. Journal of Musculoskeletal and Neuronal Interactions, 8(4), 308-10. [More Information]
  • Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gilles, R., Dart, A., Sonnabend, D., Little, C. (2008). Modulation of Aggrecan and ADAMTS Expression in Ovine Tendinopathy Induced by Altered Strain. Seminars in Arthritis and Rheumatism, 58(4), 1055-1066. [More Information]
  • Melrose, J., Hayes, A., Whitelock, J., Little, C. (2008). Perlecan, the jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.". BioEssays : news and reviews in molecular cellular and developmental biology, 30(5), 457-469. [More Information]
  • Wilson, R., Belluoccio, D., Little, C., Fosang, A., Bateman, J. (2008). Proteomic characterization of mouse cartilage degradation in vitro. Seminars in Arthritis and Rheumatism, 58(10), 3120-3131. [More Information]
  • Melrose, J., Smith, S., Little, C., Moore, R., Vernon-Roberts, B., Fraser, R. (2008). Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. European Spine Journal, 17(9), 1131-1148. [More Information]
  • Smith, M., Cake, M., Ghosh, P., Schiavinato, A., Read, R., Little, C. (2008). Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Print Edition), 47(8), 1172-1178. [More Information]
  • Melrose, J., Smith, S., Smith, M., Little, C. (2008). The use of Histochoice (tmR) for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotechnic and Histochemistry, 83(1), 47-53. [More Information]
  • Melrose, J., Smith, S., Appleyard, R., Little, C. (2007). Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc. European Spine Journal, Published online: 31 October 2007, 1-11. [More Information]
  • Alini, M., Eisenstein, S., Ito, K., Little, C., Kettler, A., Masuda, K., Melrose, J., Ralphs, J., Stokes, I., Wilke, H. (2007). Are animal models useful for studying human disc disorders/degeneration? European Spine Journal, Published online: 14 July 2007, 1-18. [More Information]
  • Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2007). Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. European Spine Journal, 16(12), 2193-2205. [More Information]
  • Little, C., Meeker, C., Golub, S., Lawlor, K., Farmer, P., Smith, S., Fosang, A. (2007). Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. Journal of Clinical Investigation, 117(6), 1627-1636. [More Information]
  • Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. (2007). Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical Orthopaedics and Related Research, 462, 212-220. [More Information]
  • Powell, A., Little, C., Hughes, C. (2007). Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system. Arthritis and Rheumatism, 56(9), 3010-3019. [More Information]
  • Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research & Therapy, 8(2), 1-6. [More Information]
  • Little, C., Mittaz, L., Belluoccio, D., Rogerson, F., Campbell, I., Meeker, C., Bateman, J., Pritchard, M., Fosang, A. (2005). ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis and Rheumatism, 52(5), 1461-1472.
  • Stanton, H., Rogerson, F., East, C., Golub, S., Lawlor, K., Meeker, C., Little, C., Last, K., Farmer, P., Campbell, I., et al (2005). ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature, 434(7033), 648-652. [More Information]
  • Fosang, A., Little, C., Meeker, C. (2005). Aggrecan knock-in mice are resistant to proteolysis by MMP or ADAMTS enzymes in the interglobular domain. Scandinavian Journal of Rheumatology, 34, 13-14.
  • Little, C., Flannery, C., Hughes, C., Goodship, A., Caterson, B. (2005). Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis and Cartilage, 13(2), 162-170. [More Information]
  • Little, C., Meeker, C., Fosang, A. (2005). Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. 51st Annual Meeting of the Orthopaedic Research Society, 30, 357.
  • Little, C., Meeker, C., Hembry, R., Sims, N., Lawlor, K., Golub, S., Last, K., Fosang, A. (2005). Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development. Molecular and Cellular Biology, 25(8), 3388-3399. [More Information]
  • Young, A., Smith, M., Smith, S., Burkhardt, D., Cake, M., Melrose, J., Read, R., Ghosh, P., Sonnabend, D., Little, C. (2005). Metabolism of Small Leucine-Rich Proteoglycans in an Ovine Model of Osteoarthritis. 51st Annual Meeting of the Orthopaedic Research Society, 30, 1057-1057.
  • Innes, J., Little, C., Hughes,, C., Caterson, B. (2005). Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early-and late-stage osteoarthritis. American Journal of Veterinary Research, 66(10), 1679-1685.
  • Yang, Y., Hall, P., Little, C., Fosang, A., Milenkovski, G., Santos, L., Xue, J., Tipping, P., Morand, E. (2005). Reduction of Arthritis Severity in Protease-Activated Receptor–Deficient Mice. Arthritis and Rheumatism, 52(4), 1325-1332.
  • Young, A., Smith, M., Smith, S., Cake, M., Ghosh, P., Read, R., Melrose, J., Sonnabend, D., Roughley, P., Little, C. (2005). Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Research & Therapy, 7(4), R852-61. [More Information]
  • Janusz, M., Little, C., King, L., Hookfin, E., Brown, K., Heitmeyer, S., Caterson, B., Poole, A., Taiwo, Y. (2004). Detection of aggrecanase and MMP-generated catabolic neoepitopes in the rat iodacetate model of cartilage degeneration. Osteoarthritis and Cartilage, 12(9), 720-728.
  • Hughes, C., Little, C., Caterson, B. (2003). Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis. Methods in Molecular Biology, 225(-), 89-98.
  • Fosang, A., Stanton, H., Little, C., Atley, L. (2003). Neoepitopes as Biomarkers of Cartilage Catabolism. Inflammation Research, 52(7), 277-282.
  • Dart, A., Little, C., Hughes, C., Chu, Q., Dowling, B., Hodgson, D., Rose, R., Johnson, K. (2003). Recombinant equine growth hormone administration: effects on synovial fluid biomarkers and cartilage metabolism in horses. Equine Veterinary Journal, 35(3), 302-307.
  • Little, C., Hughes, C., Curtis, C., Jones, S., Caterson, B., Flannery, C. (2002). Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Arthritis and Rheumatism, 46(1), 124-129.
  • Little, C., Hughes, C., Curtis, C., Janusz, M., Bohne, R., Wang-Weigand, S., Taiwo, Y., Mitchell, P., Otterness, I., Flannery, C., et al (2002). Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix biology: journal of the International Society for Matrix Biology, 21(3), 271-288.
  • Melrose, J., Smith, S., Little, C., Kitson, J., Hwa, S., Ghosh, P. (2002). Spatial and temporal localization of transforming growth factor-b, fibroblast growth factor-2, and osteonectin, and identification of cells expressing a-smooth muscle actin in the injured annulus fibrosus. Implications for extracellular matrix repair. Spine, 27(16), 1756-1764.
  • Hwa, S., Burkhardt, D., Little, C., Ghosh, P. (2001). The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis. Journal of Rheumatology, 28(4), 825-834.

Conferences

  • Melrose, J., Gooden, B., Dart, A., Appleyard, R., Little, C. (2009). Dysregulation of metalloproteinase expression in a mechanical destabilization model of intervertebral disc degeneration in sheep. ACSR Spinal Research Symposium VII.
  • Dart, A., Little, C. (2009). Focal injury induces widespread pathology in equine superficial digital flexor tendons. 31st Bain Fallon Lectures, Australia.
  • Jacobson, E., Smith, M., Mondori, T., Smith, S., Dart, A., Little, C. (2008). Focal injury induces widespread pathology in equine superficial digital flexor tendons. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
  • Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Spacio-temporal changes in pathology and proteoglycan gene expression in shoulder tendons induced by overstress or stress deprivation. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
  • Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2008). Spatial and temporal catabolism of the small leucine repeat proteoglycans (SLRPs) in an ovine annular lesion model of experimental intervertebral disc degeneration has structure-function implications. World Forum for Spine Research 2008, Switzerland: AO Foundation.
  • Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Temporal change in proteoglycan gene expression and histopathology induced in sheep shoulder tendons by altered stress in vivo. Osteoarthritis Research Society International World Congress on Osteoarthritis OARSI 2008, United States: Osteoarthritis Research Society International.
  • Smith, M., Sakurai, A., Smith, S., Young, A., Melrose, J., Dart, A., Sonnabend, D., Little, C. (2006). Altered aggrecan and ADAMTS expression in overload-induced tendon pathology. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Young, A., McLennan, S., Smith, S., Smith, M., Melrose, J., Cake, M., Flannery, C., Sonnabend, D., Little, C. (2006). Changes in expression and immunolcalization of proteoglycan 4 / lubricin in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Stewart, M., Fosang, A., Little, C., Sandy, J. (2005). A murine epiphyseal chondrocyte model of ADAMTS 5-mediated aggrecanolysis. 2005 Annual Meeting Of The American Society for Bone and Mineral Research, United States: American Society for Bone and Mineral Research.
  • Stanton, H., East, C., Golub, S., Rogerson, F., Lawlor, K., Little, C., Fosang, A. (2005). ADAMTS-5 is the major aggrecanase in cartilage: in vitro studies with ADAMTS-4 and ADAMTS-5 deficient mice. 51st Annual Meeting of Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Little, C., Meeker, C., Fosang, A. (2005). Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Little, C., Mittaz, L., Meeker, C., Pritchard, M., Fosang, A. (2004). ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in-vivo or in-vitro. 50th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Little, C., Curtis, C., Cramp, J., Vaughn-Thomas, A., Harwood, J., Innes, J., Caterson, B. (2004). Differential effects of canine cartilage to cytokine stimulation and n-3 polyunsaturated fatty acids supplementation versus human and bovine cartilage. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Little, C., Cramp, J., Curtis, C., Richardson, D., Schoenherr, B., Innes, J., Jones, S., Caterson, B. (2003). Canine articular catilage degradation: The role of catabolic cytokines. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Jones, A., Hughes, C., Wainwright, S., Flannery, C., Little, C., Caterson, B. (2003). Degradation of PRG4/SZP by Matrix Proteases. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Little, C., Meeker, C., Fosang, A. (2003). Degradative mechanisms in mouse articular cartilage:use of in vitro models to analyse proteolysis and loss of aggrecan and link protein. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Rees, A., Hughes, C., Little, C., Caterson, B. (2003). Evidence for zymogen forms of aggrecanase-1 (ADAMTS-4) in chondrocyte-agarose cultures. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Little, C., Flannery, C., Hughes, C., Precious, G., Otterness, I., Goodship, A., Caterson, B. (2002). Cytokine induced metalloproteinase expression and activity does not correlate with focal cartilage pathology. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Little, C., Roughley, P., Otterness, I., Hughes, C., Caterson, B. (2002). Hiearchical catabolism of collagen associated proteoglycans in in vitro models of progressive articular cartilage degradation. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Curtis, C., Rees, S., Little, C., Flannery, C., Hughes, C., Dent, C., Wilson, C., Harwood, J., Caterson, B. (2002). N-3 fatty acid supplementation specifically ablates the activity and expression of aggrecanases and inflammatory mediators in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Curtis, C., Little, C., Rees, S., Flannery, C., Hughes, C., Otterness, I., Dent, C., Harwood, J., Caterson, B. (2002). N-3 fatty acids inhibit expression and activity of MMPs in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Little, C., Otterness, I., Hughes, C., Caterson, B. (2002). Proteolysis of type IX collagen and loss of biglycan, decorin and fibromodulin in progressive articual cartilage degradation. Oesteoarthritis and Cartilage.
  • Davies, J., Rees, A., Hughes, C., Little, C., Caterson, B. (2001). An immunohistochemical study of aggrecan catabolism in porcine articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Diffin, F., Little, C., Elson, C., Westacott, C. (2001). Catabolism of aggrecan by cells derived from osteoarthritic bone. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Flannery, C., Little, C., Hughes, C., Curtis, C., Caterson, B. (2001). Cyclosporin A inhibits IL-1-induced aggrecanase-mediated proteoglycan catabolism in situ in articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Flannery, C., Little, C., Hughes, C., Curtis, C., Jones, S., Caterson, B. (2001). IL-6 and its soluable receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Melrose, J., Smith, S., Little, C., Kitson,, J., Hwa, S., Ghosh, P. (2001). Repair of annular disc lesions: Spatial and temporal localisation of TGF-beta, SPARC (Osteonectin, BM-40) and FGF-2 are early responses in experimentally injured ovine discs. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Little, C., Flannery, C., Hughes, C., Otterness, I., Caterson, B. (2001). Species specificity of neopitope antibodies to aggrecanase- and MMP- generated sequences in the interglobular domain of aggrecan. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Little, C., Hughes, C., Otterness, I., Janusz, M., Caterson, B. (2001). The role of matrix metalloproteinases in c-terminal catabolism of aggrecan. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.

2014

  • Smith, R., McIlwraith, W., Schweitzer, R., Kadler, K., Cook, J., Caterson, B., Dakin, S., Heinegard, D., Screen, H., Stover, S., Little, C., et al (2014). Advances in the understanding of tendinopathies: a report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal, 46(11), 4-9. [More Information]
  • Hodges, P., James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J. (2014). Can Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion? Spine, 39(13), 1010-1017. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research & Therapy, 16(1), 1-12. [More Information]
  • Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 are activated by Activated Protein C (APC) in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatism, 66(6), 1525-1536. [More Information]
  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
  • Riordan, E., Little, C., Hunter, D. (2014). Pathogenesis of post-traumatic OA with a view to intervention. Best Practice & Research: Clinical Rheumatology, 28(1), 17-30. [More Information]
  • Koenig, T., Dart, A., McIlwraith, C., Horadagoda, N., Bell, R., Perkins, N., Dart, C., Krockenberger, M., Jeffcott, L., Little, C. (2014). Treatment of Experimentally Induced Osteoarthritis in Horses Using an Intravenous Combination of Sodium Pentosan Polysulfate, N-Acetyl Glucosamine, and Sodium Hyaluronan. Veterinary Surgery, 43(5), 612-622. [More Information]

2013

  • Malfait, A., Little, C., Dougall, J. (2013). A commentary on modelling osteoarthritis pain in small animals. Osteoarthritis and Cartilage, 21(9), 1316-1326. [More Information]
  • Smith, M., Russell, A., Schiavinato, A., Little, C. (2013). A hexadecylamide derivative of hyaluronan (HYMOVIS(R)) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. Journal of Inflammation, 10(1), 1-16. [More Information]
  • Melrose, J., Smith, M., Smith, S., Ravi, V., Young, A., Dart, A., Sonnabend, D., Little, C. (2013). Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy. Tissue and Cell, 45(1), 77-82. [More Information]
  • Shu, C., Smith, S., Little, C., Melrose, J. (2013). Comparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic and osteogenic development of the human foetal spine. European Spine Journal, 22(8), 1774-1784. [More Information]
  • Cake, M., Read, R., Corfield, G., Daniel, A., Burkhardt, D., Smith, M., Little, C. (2013). Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Osteoarthritis and Cartilage, 21(1), 226-236. [More Information]
  • Smith, M., Ravi, V., Dart, A., Sonnabend, D., Little, C. (2013). Factors affecting tendinopathogenesis. British Journal of Sports Medicine, 47(9), 23-24. [More Information]
  • Smith, M., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47, 29-29.
  • Smith, M., Jacobson, E., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47(9), e2. [More Information]
  • Belluoccio, D., Rowley, L., Little, C., Bateman, J. (2013). Maintaining mRNA integrity during decalcification of mineralized tissues. PloS One, 8(3), 1-6. [More Information]
  • Little, C., Hunter, D. (2013). Post-traumatic osteoarthritis: from mouse models to clinical trials. Nature Reviews Rheumatology, 9(8), 485-497. [More Information]
  • Gossan, N., Zeef, L., Hensman, J., Hughes, A., Bateman, J., Rowley, L., Little, C., Piggins, H., Rattray, M., Boot-Handford, R., et al (2013). The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis. Arthritis & Rheumatism, 65(9), 2334-2345. [More Information]
  • Shu, C., Hughes, C., Smith, S., Smith, M., Hayes, A., Caterson, B., Little, C., Melrose, J. (2013). The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal, 30(7), 717-725. [More Information]
  • Bateman, J., Rowley, L., Belluoccio, D., Chan, B., Bell, K., Fosang, A., Little, C. (2013). Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction. Arthritis & Rheumatism, 65(6), 1547-1560. [More Information]

2012

  • Maher, A., Coles, C., White, J., Bateman, J., Fuller, E., Burkhardt, D., Little, C., Cake, M., Read, R., McDonagh, M., et al (2012). 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep. Journal of Proteome Research, 11(8), 4261-4268. [More Information]
  • Melrose, J., Isaacs, M., Smith, S., Hughes, C., Little, C., Caterson, B., Hayes, A. (2012). Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology, 138(3), 461-475. [More Information]
  • Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012). Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine, 37(1), 18-25. [More Information]
  • Boeuf, S., Graf, F., Fischer, J., Moradi, B., Little, C., Richter, W. (2012). Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells. European Cells and Materials, 23, 320-332. [More Information]
  • Chan, B., Little, C. (2012). The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis. Arthritis Research & Therapy, 14(3), 119-1-119-3. [More Information]
  • Little, C., Zaki, S. (2012). What constitutes an "animal model of osteoarthritis" - the need for consensus ? Osteoarthritis and Cartilage, 20(4), 261-267. [More Information]
  • Little, C., Zaki, S. (2012). What constitutes an ‘animal model of osteoarthritis’ ¬ the need for consensus? Osteoarthritis and Cartilage, 20(4), 261-267. [More Information]
  • Fuller, E., Smith, M., Little, C., Melrose, J. (2012). Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthritis and Cartilage, 20(1), 49-59. [More Information]

2011

  • Bernardo, B., Belluoccio, D., Rowley, L., Little, C., Hansen, U., Bateman, J. (2011). Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis. Journal of Biological Chemistry, 286(43), 37758-37767. [More Information]
  • Chan, B., Fuller, E., Russell, A., Smith, S., Smith, M., Jackson, M., Cake, M., Read, R., Bateman, J., Sambrook, P., Little, C. (2011). Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis and Cartilage, 19(7), 874-885. [More Information]
  • Stanton, H., Golub, S., Rogerson, F., Last, K., Little, C., Fosang, A. (2011). Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nature Protocols, 6(3), 388-404. [More Information]
  • Lamande, S., Yuan, Y., Gresshoff, I., Rowley, L., Belluoccio, D., Kaluarachchi, K., Little, C., Botzenhart, E., Zerres, K., Amor, D., et al (2011). Mutations in TRPV4 cause an inherited arthropathy of hands and feet. Nature Genetics, 43(11), 1142-1146. [More Information]
  • Stanton, H., Melrose, J., Little, C., Fosang, A. (2011). Proteoglycan degradation by the ADAMTS family of proteinases. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1812 (12), 1616-1629. [More Information]
  • Glasson, S., Little, C. (2011). The recent paper "Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity". Osteoarthritis and Cartilage, 19(8), 1076-1077. [More Information]

2010

  • Schollum, M., Appleyard, R., Little, C., Melrose, J. (2010). A Detailed Microscopic Examination of Alterations in Normal Anular Structure Induced by Mechanical Destabilization in an Ovine Model of Disc Degeneration. Spine, 35(22), 1965-1973. [More Information]
  • Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
  • Aigner, T., Cook, J., Gerwin, N., Glasson, S., Laverty, S., Little, C., McIlwraith, W., Kraus, V. (2010). Histopathology atlas of animal model systems - overview of guiding principles. Osteoarthritis and Cartilage, 18(SUPPL. 3), S2-S6. [More Information]
  • Melrose, J., Little, C. (2010). Immunolocalization of lymphatic vessels in human fetal knee joint tissues. Connective Tissue Research, 51(4), 289-305. [More Information]
  • Little, C., Fosang, A. (2010). Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis - insights from studies of aggrecan and collagen proteolysis? Current Drug Targets, 11(5), 561-575. [More Information]
  • Fosang, A., Last, K., Stanton, H., Golub, S., Little, C., Brown, L., Jackson, D. (2010). Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan. Methods in Molecular Biology (Clifton N.J.), 622, 312-47. [More Information]
  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research & Therapy, 12(1), 1-13. [More Information]
  • Little, C., Kim, Y. (2010). Targeting Cartilage Breakdown in Osteoarthritis. Journal of American Academy of Orthopaedic Surgeons, 18(4), 243-246.
  • Little, C., Smith, M., Cake, M., Read, R., Murphy, M., Barry, F. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis and Cartilage, 18(Suppl 3), S80-S92. [More Information]
  • Little, C. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis and Cartilage, 18(3), S17-23. [More Information]

2009

  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis and Rheumatism, 60(3), 780-791. [More Information]
  • Melrose, J., Burkhardt, D., Taylor, T., Dillon, C., Read, R., Cake, M., Little, C. (2009). Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease. European Spine Journal, 18(4), 479-489. [More Information]
  • Melrose, J., Gooden, B., Dart, A., Appleyard, R., Little, C. (2009). Dysregulation of metalloproteinase expression in a mechanical destabilization model of intervertebral disc degeneration in sheep. ACSR Spinal Research Symposium VII.
  • Dart, A., Little, C. (2009). Focal injury induces widespread pathology in equine superficial digital flexor tendons. 31st Bain Fallon Lectures, Australia.
  • Little, C., Barai, A., Burkhardt, D., Smith, S., Fosang, A., Werb, Z., Shah, M., Thompson, E. (2009). Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Care and Research, 60(12), 3723-3733. [More Information]
  • Smith, S., Whitelock, J., Iozzo, R., Little, C., Melrose, J. (2009). Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Histochemistry and Cell Biology, 132(5), 491-503. [More Information]

2008

  • Little, C., Smith, M. (2008). Animal Models of Osteoarthritis. Current Rheumatology Reviews, 4(3), 175-182. [More Information]
  • Cake, M., Read, R., Edwards, S., Smith, M., Burkhardt, D., Little, C., Ghosh, P. (2008). Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. Journal of orthopaedic science, 13(6), 514-523. [More Information]
  • Fosang, A., Little, C. (2008). Drug insight: aggrecanases as therapeutic targets for osteoarthritis. Nature clinical practice: Rheumatology, 4(8), 420-427. [More Information]
  • Fitzgerald, J., Rich, C., Burkhardt, B., Allen, J., Herzka, A., Little, C. (2008). Evidence for articular cartilage regeneration in MRL/MpJ mice. Osteoarthritis and Cartilage, 16(11), 1319-1326. [More Information]
  • Jacobson, E., Smith, M., Mondori, T., Smith, S., Dart, A., Little, C. (2008). Focal injury induces widespread pathology in equine superficial digital flexor tendons. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
  • Melrose, J., Fuller, E., Roughley, P., Smith, M., Kerr, B., Hughes, C., Caterson, B., Little, C. (2008). Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Research & Therapy, 10(doi:10.1186/ar2453), 1-10. [More Information]
  • Gauci, S., Golub, S., Tutolo, L., Little, C., Sims, N., Lee, E., Mackie, E., Fosang, A. (2008). Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage. Journal of Musculoskeletal and Neuronal Interactions, 8(4), 308-10. [More Information]
  • Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gilles, R., Dart, A., Sonnabend, D., Little, C. (2008). Modulation of Aggrecan and ADAMTS Expression in Ovine Tendinopathy Induced by Altered Strain. Seminars in Arthritis and Rheumatism, 58(4), 1055-1066. [More Information]
  • Melrose, J., Hayes, A., Whitelock, J., Little, C. (2008). Perlecan, the jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.". BioEssays : news and reviews in molecular cellular and developmental biology, 30(5), 457-469. [More Information]
  • Wilson, R., Belluoccio, D., Little, C., Fosang, A., Bateman, J. (2008). Proteomic characterization of mouse cartilage degradation in vitro. Seminars in Arthritis and Rheumatism, 58(10), 3120-3131. [More Information]
  • Melrose, J., Smith, S., Little, C., Moore, R., Vernon-Roberts, B., Fraser, R. (2008). Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. European Spine Journal, 17(9), 1131-1148. [More Information]
  • Smith, M., Cake, M., Ghosh, P., Schiavinato, A., Read, R., Little, C. (2008). Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Print Edition), 47(8), 1172-1178. [More Information]
  • Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Spacio-temporal changes in pathology and proteoglycan gene expression in shoulder tendons induced by overstress or stress deprivation. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
  • Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2008). Spatial and temporal catabolism of the small leucine repeat proteoglycans (SLRPs) in an ovine annular lesion model of experimental intervertebral disc degeneration has structure-function implications. World Forum for Spine Research 2008, Switzerland: AO Foundation.
  • Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Temporal change in proteoglycan gene expression and histopathology induced in sheep shoulder tendons by altered stress in vivo. Osteoarthritis Research Society International World Congress on Osteoarthritis OARSI 2008, United States: Osteoarthritis Research Society International.
  • Melrose, J., Smith, S., Smith, M., Little, C. (2008). The use of Histochoice (tmR) for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotechnic and Histochemistry, 83(1), 47-53. [More Information]

2007

  • Melrose, J., Smith, S., Appleyard, R., Little, C. (2007). Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc. European Spine Journal, Published online: 31 October 2007, 1-11. [More Information]
  • Alini, M., Eisenstein, S., Ito, K., Little, C., Kettler, A., Masuda, K., Melrose, J., Ralphs, J., Stokes, I., Wilke, H. (2007). Are animal models useful for studying human disc disorders/degeneration? European Spine Journal, Published online: 14 July 2007, 1-18. [More Information]
  • Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2007). Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. European Spine Journal, 16(12), 2193-2205. [More Information]
  • Little, C., Meeker, C., Golub, S., Lawlor, K., Farmer, P., Smith, S., Fosang, A. (2007). Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. Journal of Clinical Investigation, 117(6), 1627-1636. [More Information]
  • Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. (2007). Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical Orthopaedics and Related Research, 462, 212-220. [More Information]
  • Smith, M., Little, C. (2007). Experimental Models of Osteoarthritis. In Moskowitz, Altman, Hochberg, Buckwalter & Glodberg (Eds.), Osteoarthritis: Diagnosis and Medical/ Surgical Management, (pp. 107-125). Philadelphia, USA: Lippincott Williams & Wilkins.
  • Powell, A., Little, C., Hughes, C. (2007). Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system. Arthritis and Rheumatism, 56(9), 3010-3019. [More Information]

2006

  • Smith, M., Sakurai, A., Smith, S., Young, A., Melrose, J., Dart, A., Sonnabend, D., Little, C. (2006). Altered aggrecan and ADAMTS expression in overload-induced tendon pathology. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Young, A., McLennan, S., Smith, S., Smith, M., Melrose, J., Cake, M., Flannery, C., Sonnabend, D., Little, C. (2006). Changes in expression and immunolcalization of proteoglycan 4 / lubricin in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research & Therapy, 8(2), 1-6. [More Information]

2005

  • Stewart, M., Fosang, A., Little, C., Sandy, J. (2005). A murine epiphyseal chondrocyte model of ADAMTS 5-mediated aggrecanolysis. 2005 Annual Meeting Of The American Society for Bone and Mineral Research, United States: American Society for Bone and Mineral Research.
  • Little, C., Mittaz, L., Belluoccio, D., Rogerson, F., Campbell, I., Meeker, C., Bateman, J., Pritchard, M., Fosang, A. (2005). ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis and Rheumatism, 52(5), 1461-1472.
  • Stanton, H., East, C., Golub, S., Rogerson, F., Lawlor, K., Little, C., Fosang, A. (2005). ADAMTS-5 is the major aggrecanase in cartilage: in vitro studies with ADAMTS-4 and ADAMTS-5 deficient mice. 51st Annual Meeting of Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Stanton, H., Rogerson, F., East, C., Golub, S., Lawlor, K., Meeker, C., Little, C., Last, K., Farmer, P., Campbell, I., et al (2005). ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature, 434(7033), 648-652. [More Information]
  • Fosang, A., Little, C., Meeker, C. (2005). Aggrecan knock-in mice are resistant to proteolysis by MMP or ADAMTS enzymes in the interglobular domain. Scandinavian Journal of Rheumatology, 34, 13-14.
  • Little, C., Flannery, C., Hughes, C., Goodship, A., Caterson, B. (2005). Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis and Cartilage, 13(2), 162-170. [More Information]
  • Little, C., Meeker, C., Fosang, A. (2005). Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Little, C., Meeker, C., Fosang, A. (2005). Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. 51st Annual Meeting of the Orthopaedic Research Society, 30, 357.
  • Little, C., Meeker, C., Hembry, R., Sims, N., Lawlor, K., Golub, S., Last, K., Fosang, A. (2005). Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development. Molecular and Cellular Biology, 25(8), 3388-3399. [More Information]
  • Young, A., Smith, M., Smith, S., Burkhardt, D., Cake, M., Melrose, J., Read, R., Ghosh, P., Sonnabend, D., Little, C. (2005). Metabolism of Small Leucine-Rich Proteoglycans in an Ovine Model of Osteoarthritis. 51st Annual Meeting of the Orthopaedic Research Society, 30, 1057-1057.
  • Innes, J., Little, C., Hughes,, C., Caterson, B. (2005). Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early-and late-stage osteoarthritis. American Journal of Veterinary Research, 66(10), 1679-1685.
  • Yang, Y., Hall, P., Little, C., Fosang, A., Milenkovski, G., Santos, L., Xue, J., Tipping, P., Morand, E. (2005). Reduction of Arthritis Severity in Protease-Activated Receptor–Deficient Mice. Arthritis and Rheumatism, 52(4), 1325-1332.
  • Young, A., Smith, M., Smith, S., Cake, M., Ghosh, P., Read, R., Melrose, J., Sonnabend, D., Roughley, P., Little, C. (2005). Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Research & Therapy, 7(4), R852-61. [More Information]

2004

  • Little, C., Mittaz, L., Meeker, C., Pritchard, M., Fosang, A. (2004). ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in-vivo or in-vitro. 50th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Hughes, C., Caterson, B., Little, C., Wright, S. (2004). Aggrecanases 1 and 2. In Woessner F, Alan J. Barrett, Neil D. Rawlings (Eds.), Handbook of Proteolytic Enzymes, (pp. 740-740). Canada: Academic Press.
  • Janusz, M., Little, C., King, L., Hookfin, E., Brown, K., Heitmeyer, S., Caterson, B., Poole, A., Taiwo, Y. (2004). Detection of aggrecanase and MMP-generated catabolic neoepitopes in the rat iodacetate model of cartilage degeneration. Osteoarthritis and Cartilage, 12(9), 720-728.
  • Little, C., Curtis, C., Cramp, J., Vaughn-Thomas, A., Harwood, J., Innes, J., Caterson, B. (2004). Differential effects of canine cartilage to cytokine stimulation and n-3 polyunsaturated fatty acids supplementation versus human and bovine cartilage. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.

2003

  • Little, C., Cramp, J., Curtis, C., Richardson, D., Schoenherr, B., Innes, J., Jones, S., Caterson, B. (2003). Canine articular catilage degradation: The role of catabolic cytokines. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Jones, A., Hughes, C., Wainwright, S., Flannery, C., Little, C., Caterson, B. (2003). Degradation of PRG4/SZP by Matrix Proteases. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Little, C., Meeker, C., Fosang, A. (2003). Degradative mechanisms in mouse articular cartilage:use of in vitro models to analyse proteolysis and loss of aggrecan and link protein. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Rees, A., Hughes, C., Little, C., Caterson, B. (2003). Evidence for zymogen forms of aggrecanase-1 (ADAMTS-4) in chondrocyte-agarose cultures. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Hughes, C., Little, C., Caterson, B. (2003). Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis. Methods in Molecular Biology, 225(-), 89-98.
  • Fosang, A., Stanton, H., Little, C., Atley, L. (2003). Neoepitopes as Biomarkers of Cartilage Catabolism. Inflammation Research, 52(7), 277-282.
  • Dart, A., Little, C., Hughes, C., Chu, Q., Dowling, B., Hodgson, D., Rose, R., Johnson, K. (2003). Recombinant equine growth hormone administration: effects on synovial fluid biomarkers and cartilage metabolism in horses. Equine Veterinary Journal, 35(3), 302-307.

2002

  • Little, C., Hughes, C., Curtis, C., Jones, S., Caterson, B., Flannery, C. (2002). Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Arthritis and Rheumatism, 46(1), 124-129.
  • Little, C., Flannery, C., Hughes, C., Precious, G., Otterness, I., Goodship, A., Caterson, B. (2002). Cytokine induced metalloproteinase expression and activity does not correlate with focal cartilage pathology. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Little, C., Roughley, P., Otterness, I., Hughes, C., Caterson, B. (2002). Hiearchical catabolism of collagen associated proteoglycans in in vitro models of progressive articular cartilage degradation. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Little, C., Hughes, C., Curtis, C., Janusz, M., Bohne, R., Wang-Weigand, S., Taiwo, Y., Mitchell, P., Otterness, I., Flannery, C., et al (2002). Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix biology: journal of the International Society for Matrix Biology, 21(3), 271-288.
  • Curtis, C., Rees, S., Little, C., Flannery, C., Hughes, C., Dent, C., Wilson, C., Harwood, J., Caterson, B. (2002). N-3 fatty acid supplementation specifically ablates the activity and expression of aggrecanases and inflammatory mediators in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Curtis, C., Little, C., Rees, S., Flannery, C., Hughes, C., Otterness, I., Dent, C., Harwood, J., Caterson, B. (2002). N-3 fatty acids inhibit expression and activity of MMPs in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
  • Little, C., Otterness, I., Hughes, C., Caterson, B. (2002). Proteolysis of type IX collagen and loss of biglycan, decorin and fibromodulin in progressive articual cartilage degradation. Oesteoarthritis and Cartilage.
  • Melrose, J., Smith, S., Little, C., Kitson, J., Hwa, S., Ghosh, P. (2002). Spatial and temporal localization of transforming growth factor-b, fibroblast growth factor-2, and osteonectin, and identification of cells expressing a-smooth muscle actin in the injured annulus fibrosus. Implications for extracellular matrix repair. Spine, 27(16), 1756-1764.

2001

  • Davies, J., Rees, A., Hughes, C., Little, C., Caterson, B. (2001). An immunohistochemical study of aggrecan catabolism in porcine articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Diffin, F., Little, C., Elson, C., Westacott, C. (2001). Catabolism of aggrecan by cells derived from osteoarthritic bone. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Flannery, C., Little, C., Hughes, C., Curtis, C., Caterson, B. (2001). Cyclosporin A inhibits IL-1-induced aggrecanase-mediated proteoglycan catabolism in situ in articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Flannery, C., Little, C., Hughes, C., Curtis, C., Jones, S., Caterson, B. (2001). IL-6 and its soluable receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Melrose, J., Smith, S., Little, C., Kitson,, J., Hwa, S., Ghosh, P. (2001). Repair of annular disc lesions: Spatial and temporal localisation of TGF-beta, SPARC (Osteonectin, BM-40) and FGF-2 are early responses in experimentally injured ovine discs. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Little, C., Flannery, C., Hughes, C., Otterness, I., Caterson, B. (2001). Species specificity of neopitope antibodies to aggrecanase- and MMP- generated sequences in the interglobular domain of aggrecan. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
  • Hwa, S., Burkhardt, D., Little, C., Ghosh, P. (2001). The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis. Journal of Rheumatology, 28(4), 825-834.
  • Little, C., Hughes, C., Otterness, I., Janusz, M., Caterson, B. (2001). The role of matrix metalloproteinases in c-terminal catabolism of aggrecan. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.

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