Professor Christopher Semsarian

MBBS PhD FRACP FCSANZ FHRS FAHA
NHMRC Practitioner Fellow
Professor of Medicine, Sydney Medical School
Cardiologist, Royal Prince Alfred Hospital, Central Clinical School
Head, Molecular Cardiology Program, Centenary Institute

Telephone +61 2 9565 6195
Fax +61 2 9565 6101

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Biographical details

Professor Christopher (Chris) Semsarian is an internationally renowned physician-scientist – he is a cardiologist and basic scientist specialising in research on genetic heart disease and sudden death and the management (prevention and treatment) of individuals and families with or at risk of inherited cardiac disorders. He is Professor of Medicine and NHMRC Practitioner Fellow at the University of Sydney, Visiting Cardiologist at the Royal Prince Alfred Hospital, Director of the Genetic Heart Disease and Hypertrophic Cardiomyopathy Clinic at the hospital, Head of the Molecular Cardiology Program at the Centenary Institute, and Director of the Australian Genetic Heart Disease Registry. Prof Semsarian’s research focuses on identifying new genes in cardiovascular disease, elucidating the molecular basis of how these genes lead to the clinical manifestations, and evaluating the role of modifying factors in clinical disease development and progression. A graduate of the University of Sydney (MBBS) Prof Semsarian undertook specialist training in cardiology and later completed a PhD through the Victor Chang Cardiac Research Institute, studying the molecular and clinical aspects of cardiac hypertrophy, which resulted in a first author publication in Nature. Subsequently, he worked as a postdoctoral Research Associate at the Department of Genetics, Harvard Medical School, USA. On return to Australia in 2002, he established the Molecular Cardiology Program at the Centenary Institute, University of Sydney. In 2003, Prof Semsarian established Australia’s first tertiary referral multi-disciplinary Genetic Heart Disease and Hypertrophic Cardiomyopathy Clinic at the Royal Prince Alfred Hospital which receives referrals from around Sydney and regional NSW. The clinic also facilitates as a training centre for FRACP trainees and genetic counseling students. Prof Semsarian has since lent his expertise to the Health Departments of Queensland and Victoria to help establish similar clinics in these States. The clinic along with the Molecular Cardiology Program serves as a national centre of research and clinical excellence in genetic heart disease and sudden death, by combining patient management and prevention of sudden death in at-risk families, with cutting-edge research in the field – and where the results of basic molecular research have translated to advances in clinical care. Prof Semsarian has an excellent research track record – he has received continuous NHMRC Project Grant funding since 2003 and has published widely with >140 peer-reviewed scientific papers in leading journals including Nature, Journal of Clinical Investigation, Lancet, Circulation, Circulation Research, Journal of Medical Genetics, and Journal of the American College of Cardiology. He has written or co-authored many of the best practice guidelines in Australia on genetic heart diseases and sudden death and in 2011 he was the only non-USA, non-European member of the International Genetic Testing Guidelines Committee. Prof Semsarian has received numerous prestigious awards recognising his research contributions – in 2009 he was awarded the Royal Prince Alfred Hospital Medal for excellence in medical scientific research, and in 2010 his work was listed in the NHMRC’s Ten of the Best research studies that year. In 2012, Prof Semsarian received the Cardiac Society of Australia and New Zealand (CSANZ) RT Hall Research Prize, the highest research award given by the CSANZ each year. He has been a NHMRC Practitioner Fellow since 2004. Prof Semsarian collaborates widely – with researchers in every state and territory in Australia and New Zealand and internationally in the USA and Italy. He and his team have been involved in a major database and patient support initiative through the establishment in 2008 of the Australian Genetic Heart Disease Registry – www.heartregistry.org.au, which aims to enroll every Australian family with genetic heart disease and currently includes >1000 families. “This was a labour of love” says Prof Semsarian. “We started the registry and have continued it with little external funding – our sole purpose being to help families. The registry covers all known genetic heart conditions and is the only such registry worldwide. Establishing a National registry requires collaboration between all States and Territories, an enormous undertaking that is unattainable in many countries. We are the envy of the world – and very proud of this achievement”.

Prof Semsarian also has a substantial involvement in research promotion, teaching, outreach and advocacy. He is a member of the editorial board of the journals Heart Rhythm and Circulation CV Genetics, and he is an Associate Editor of the International Journal of Cardiology. In 2003, he helped to establish the CSANZ’s Cardiovascular, Genetic Working Group, which he Chaired until 2007. He is a member of the Research Committees of the CSANZ and the National Heart Foundation of Australia and is Director of the Board of the Hearts4Heart Charity. Prof Semsarian teaches medical students and FRACP trainees and presents lectures to nursing stuff, psychiatry trainees, and overseas doctors training in Australia. Since 2005, he has been Postgraduate Coordinator for the Centenary Institute. Additionally, Prof Semsarian spends one week each year as part of the international team for the “500 Hearts” project in rural Cambodia, where he is involved in screening for the risk of rheumatic heart disease in Cambodian children in remote villages. In 2007, he established the Kempsey Indigenous Heart Disease Clinic, a free clinic for the local Indigenous community in Northern NSW – which is run approximately 3-4 times each year to educate the local community and improve heart health, specifically in the young. He maintains a strong involvement in raising awareness of cardiac research in the wider community – having presented talks to community groups on cardiac health issues and on the importance of research. Prof Semsarian is involved with the NSW AFL in raising awareness of sudden cardiac death in athletes and of the importance of public access defibrillators.

Research interests

Prof Semsarian is a cardiologist and basic biological scientist studying the molecular, genetic, clinical and translational aspects of cardiovascular disorders that have a genetic basis (i.e. genetic heart disease). He has a particular interest in cardiomyopathies and sudden cardiac death in the young including investigation and prevention of sudden cardiac death in children and young adults. He is an internationally-recognised expert in the field of sudden death and its genetic evaluation. Prof Semsarian and his team have contributed significantly to the understanding of inherited cardiovascular disorders and sudden death, about which little was known even a decade ago. He has bridged the interface between basic and clinical research to help prevent the complications of genetic heart disease in the community. His research has identified new genes involved in hypertrophic cardiomyopathy and the mechanism of associated cardiac muscle impairment. The work resulted in a paradigm shift in the understanding of genetic diseases with the discovery that some families with severe hypertrophic cardiomyopathy carried mutations in two genes associated with the disease. This has led to improved diagnosis, therapies to prevent complications, and better risk management strategies to prevent heart failure and sudden death in patients with genetic cardiovascular disease. Prof Semsarian also contributed to a recent international multicenter study, which demonstrated a significantly reduced risk of sudden death associated with ICD implantation in children and adolescents with hypertrophic cardiomyopathy. In addition,his team has demonstrated the usefulness of exome sequencing in the post-mortem setting to investigate the cause of sudden death in the young.

Current research at the Molecular Cardiology Program encompasses several distinct streams including: (a) application of genetic technologies for the discovery of novel genes associated with inherited cardiovascular diseases – using the extensive database in the Australian Genetic Heart Disease Registry, of families that have undergone thorough clinical evaluation; (b) elucidating how gene defects activate signaling pathways to cause disease (d) continued use of exome sequencing to perform molecular autopsies for the identification of novel genes implicated in sudden death in the young and to evaluate at-risk families; (d) developing improved multidisciplinary care models of clinical and psychosocial behavioural interventions for individuals and families at risk of genetic heart disease – particularly identifying impaired functioning or quality of life after a diagnosis of genetic heart disease or evidence of post-traumatic stress disorder after ICD implantation. The overall aim of this research stream is to identify risk factors for deteriorating mental health associated with a diagnosis of genetic heart disease and to develop evidence-based strategies for multimodal management.

Currently Prof Semsarian is enrolled in a Masters of Public Health Program at the University of Sydney with a view to establishing future research direction in his laboratory. He says “the past ten years have seen major advances in gene technology – we now have the ability to screen >20,000 genes in as little as six weeks. With our knowledge of genes implicated in cardiovascular disease in individuals and families, the natural next step is to look for these and other genetic markers from a broader population perspective. The MPH degree teaches the rigour of methodological design for large population health studies and also improves understanding of the implications of study conduct and outcomes”.

In the media

1. Feature story on sudden cardiac death on Catalyst, ABC Television, November 2004 http://www.abc.net.au/catalyst/stories/s1251441.htm

2. Interview regarding collapsed Olympic athlete onA Current Affair, Channel 9, September 2004.

3. Interviews on ABC Radio / Radio National (several)

4. Featured in National Heart Foundation national TV commercial promoting heart research.

5. Interview on Asia-Pacific ABC Radio regarding genes in heart disease, 2006.

6. Interview on Radio 2SM – about National Cardiomyopathy Day, August 2006.

7. Interview on Radio 2SM – about World Heart Rhythm Day, 13 June 2007

8. Featured story on 730 Report: Cardiologist unlocks genetic mystery of sudden death. ABC Television, February 2008.

9. Radio interviews (2BL, 2GG, 2SM) on National Genetic Heart Disease Registry, August 2009.

10. Story on Gene Patents on Four Corners, ABC Television, September 2010 http://www.abc.net.au/4corners/content/2010/s3000623.htm

11. Story on sudden death in the young on Sunrise, Channel 7, October 2010.

12. Story on sudden death in the young on 7pm Project, Channel 10, February 2011.

13. Interview on ABC Radio on sudden death in the young, March 2011.

14. Feature story on sudden death on 630 with Negus, Channel 10, August 2011.

15. Feature story on sudden death on 60 Minutes, Channel 9, December 2011.

16. Feature story on energy drinks as triggers for heart attacks, NineMSN, January 2012.

17. Interview on Fox Sports TV News & Views, about heart disease in athletes, March 2012.

18. Interview on ABC Newcastle about sudden death in the young, April 2012.

19. Interview on ABC Ballarat about sudden death in athletes, April 2012.

20. Podcast interview on “A Game of Two Halves” about sudden death in athletes, including EPL players, April 2012.

21. Feature story on cardiac effects of energy drinks on SBS World News, SBS, October 2012.

22. Feature story on Catalyst, ABC Television, Dangers of Energy Drinks, August 2013 http://www.abc.net.au/catalyst/stories/3826162.htm

23. Feature story on Caffeine Strips on ABC News, ABC Television, April 2014.

24. Feature story on Genomic Technologies on Nine News, Channel 9, May 2014.

25. Articles in The Guardian Australia and The Glow (2014) on sudden cardiac death in young adults: http://www.theguardian.com/world/2014/aug/12/sudden-cardiac-arrest-up-to-five-australians-under-35-die-each-week

http://www.theglow.com.au/health/cardiac-arrest-in-young-adults/

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

International links

United States

(Harvard Medical School, Boston) Collaborate on genetic studies in heart disease

Selected grants

2015

  • Cardiovascular Effects of Energy Drinks; Gray B, Semsarian C, Driscoll T; Heart Foundation of Australia/Vanguard Grant.

2014

  • Practitioner Fellowship Level 2 - Clinical and Genetic Studies in Inherited Heart Diseases and Sudden Death; Semsarian C; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2013

  • Clinical and Genetic Basis of Sudden Unexplained Death in Children; Semsarian C, Weintraub R; Financial Markets Foundation for Children/Research Support.
  • New Gene Discovery in Familial Hypertrophic Cardiomyopathy; Semsarian C, Bagnall R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas de St Groth B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Genetic testing in children at risk of genetic heart disease: optimizing clinical care; Ingles J, Semsarian C; Thrasher Research Fund/Research Support.
  • Neuro-Cardiac Genetic Basis of Sudden Unexpected Death in Epilepsy; Semsarian C, Crompton D, Bagnall R; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Neuro-Cardiac Genetic Basis of Sudden Unexpected Death in Epilepsy (SUDEP); Semsarian C, Scheffer I; Citizens United for Research in Epilepsy (CURE)/Research Support.
  • Genetic Basis of Valvular Heart Disease; Semsarian C, Weintraub R, Winlaw D, Bagnall R; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Investigation of sudden cardiac death in the young; Semsarian C, Weintraub R, Weintraub R, Duflou J, Puranik R, Skinner J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Key role of connective tissue growth factor (CTGF) in familial cardiomyopathy and heart failure; Semsarian C, Twigg S, Tsoutsman T; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Clinical and Genetic Studies in Inherited Heart Disease and Sudden Death; Semsarian C; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2008

  • Multiple Mutations in Familial Cardiomyopathy: Cahracterisation and Treatment Studies; Tsoutsman T, Semsarian C; Heart Foundation of Australia/Grants-in-Aid.

2007

  • Genetic predisposition to sudden cardiac death in young people with type 1 diabetes; Semsarian C; National Heart Foundation/Research Grants.

2006

  • Novel Insights Into The Genetic Basis Of Hypertrophic Cardiomyopathy: Candidate Genes Related To Calcium (Ca 2+) Handling; Semsarian C; National Heart Foundation/Grants-in-Aid.
  • NHMRC - Practitioner Fellowship; Semsarian C; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2005

  • Genetic basis of sudden cardiac death in the young; Semsarian C; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Molecular studies in hypertrophic cardiomyopathy; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2003

  • Modifying factors and phenotype heterogeneity in familial hypertrophic cardiomyopathy; Semsarian C; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Burns, C., Semsarian, C., Ingles, J. (2014). Access, uptake and communication of genetic test results in Australian families with long QT syndrome (LQTS). Heart, Lung and Circulation, 23(S2), e7.
  • Gray, B., Semsarian, C., Sy, R. (2014). Brugada Syndrome: A Heterogeneous Disease with a Common ECG Phenotype? Journal of Cardiovascular Electrophysiology, 25(4), 450-456. [More Information]
  • Driscoll, E., Ingles, J., Semsarian, C. (2014). Clinical and genetic characteristics of hypertrophic cardiomyopathy patients with end-stage disease: A registry-based study. Heart, Lung and Circulation, 23(S2), e8-e9.
  • Puranik, R., Gray, B., Lackey, H., Duflou, J., Yeates, L., Parker, G., Semsarian, C. (2014). Comparison of conventional autopsy and magnetic resonance imaging in determining the cause of sudden death in the young. Journal of Cardiovascular Magnetic Resonance, 16(1), 1-11. [More Information]
  • Ingles, J., Semsarian, C. (2014). Conveying a probabilistic genetic test result to families with an inherited heart disease. Heart Rhythm, 11(6), 1073-1078. [More Information]
  • Padang, R., Dennis, M., Semsarian, C., Bannon, P., Tanous, D., Celermajer, D., Puranik, R. (2014). Detection of Serious Complications by MR Imaging in Asymptomatic Young Adults with Repaired Coarctation of the Aorta. Heart, Lung and Circulation, 23(4), 332-338. [More Information]
  • Das K, J., Ingles, J., Bagnall, R., Semsarian, C. (2014). Determining pathogenicity of genetic variants in hypertrophic cardiomyopathy: importance of periodic reassessment. Genetics in Medicine, 16(4), 286-293. [More Information]
  • Bagnall, R., Das K, J., Duflou, J., Semsarian, C. (2014). Exome analysis–based molecular autopsy in cases of sudden unexplained death in the young. Heart Rhythm, 11(4), 655-662. [More Information]
  • Bagnall, R., Crompton, D., Cutmore, C., Regan, B., Scheffer, I., Semsarian, C. (2014). Genetic analysis of PHOX2B in sudden unexpected death in epilepsy cases. Neurology, 83(11), 1018-1021. [More Information]
  • Brunklaus, A., Ellis, R., Reavey, E., Semsarian, C., Zuberi, S. (2014). Genotype phenotype associations across the voltage-gated sodium channel family. Journal of Medical Genetics, 51, 650-658. [More Information]
  • Maron, B., Ommen, S., Semsarian, C., Spirito, P., Olivotto, I., Maron, M. (2014). Hypertrophic cardiomyopathy: Present and future, with translation into contemporary cardiovascular medicine. Journal of the American College of Cardiology, 64(1), 83-99. [More Information]
  • Bagnall, R., Ingles, J., Semsarian, C. (2014). Illumina TruSight Cardiomyopathy Sequencing Panel: Application to hypertrophic cardiomyopathy. Heart, Lung and Circulation, 23(S2), e5.
  • Femia, G., Hsu, C., Singarayar, S., Sy, R., Kilborn, M., Parker, G., McGuire, M., Semsarian, C., Puranik, R. (2014). Impact of new task force criteria in the diagnosis of arrhythmogenic right ventricular cardiomyopathy. International Journal of Cardiology, 171(2), 179-183. [More Information]
  • Gray, B., McGuire, M., Semsarian, C., Medi, C. (2014). Late positive flecainide challenge test for Brugada syndrome. Heart Rhythm, 11(5), 898-900. [More Information]
  • Spirito, P., Autore, C., Formisano, F., Gabriele, E., Biagini, E., Haas, T., Bongioanni, S., Semsarian, C., Devoto, E., Yeates, L., et al (2014). Risk of sudden death and outcome in patients with hypertrophic cardiomyopathy with benign presentation and without risk factors. The American Journal of Cardiology, 113(9), 1550-1555. [More Information]
  • Semsarian, C., Sweeting, J., Ingles, J. (2014). Sudden death in athletes: Preventable or inevitable? Heart Rhythm, 11(10), 682-683. [More Information]
  • Ingles, J., Semsarian, C. (2014). The value of cardiac genetic testing. Trends In Cardiovascular Medicine, 24(6), 217-224. [More Information]
  • Tsoutsman, T., Wang, X., Garchow, K., Riser, B., Twigg, S., Semsarian, C. (2013). CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. Journal of Molecular and Cellular Cardiology, 62, 164-178. [More Information]
  • Ingles, J., Sarina, T., Yeates, L., Hunt, L., Macciocca, I., McCormack, L., Winship, I., McGaughran, J., Atherton, J., Semsarian, C. (2013). Clinical predictors of genetic testing outcomes in hypertrophic cardiomyopathy. Genetics in Medicine, 15(12), 972-977. [More Information]
  • Semsarian, C., Ingles, J. (2013). Expanding the genetic spectrum of hypertrophic cardiomyopathy: x marks the spot. Circulation Cardiovascular Genetics, 6(6), 528-530. [More Information]
  • Costa, M., Guo, G., Wolstein, O., Vale, M., Castro, M., Wang, L., Otway, R., Riek, R., Cochrane, N., Furtado, M., Semsarian, C., et al (2013). Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy. Circulation Cardiovascular Genetics, 6(3), 238-247. [More Information]
  • Ingles, J., Yeates, L., Hunt, L., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2013). Health status of cardiac genetic disease patients and their at-risk relatives. International Journal of Cardiology, 165(3), 448-453. [More Information]
  • Gray, B., Yeates, L., Medi, C., Ingles, J., Semsarian, C. (2013). Homozygous mutation in the cardiac troponin I gene: Clinical heterogeneity in hypertrophic cardiomyopathy. International Journal of Cardiology, 168(2), 1530-1531. [More Information]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology: cellular and molecular biology of disease, 183(3), 745-757. [More Information]
  • Figtree, G., Bagnall, R., Abdulla, I., Buchholz, S., Karimi Galougahi, K., Yan, W., Tan, T., Neil, C., Horowitz, J., Semsarian, C., Ward, M. (2013). No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. European Journal of Heart Failure, 15(7), 730-733. [More Information]
  • Semsarian, C., Weintraub, R. (2013). Paediatric cardiomyopathy: Getting to the heart of the matter. The Lancet, 382(9908), 1866-1867. [More Information]
  • Yeates, L., Hunt, L., Saleh, M., Semsarian, C., Ingles, J. (2013). Poor psychological wellbeing particularly in mothers following sudden cardiac death in the young. European Journal of Cardiovascular Nursing, 12(5), 484-491. [More Information]
  • Sweeting, J., Duflou, J., Semsarian, C. (2013). Postmortem analysis of cardiovascular deaths in schizophrenia: A 10-year review. Schizophrenia Research, 150(2-3), 398-403. [More Information]
  • Evans, A., Bagnall, R., Duflou, J., Semsarian, C. (2013). Postmortem review and genetic analysis in sudden infant death syndrome: an 11-year review. Human Pathology, 44(9), 1730-1736. [More Information]
  • Maron, B., Spirito, P., Ackerman, M., Casey, S., Semsarian, C., Estes, N., Shannon, K., Ashley, E., Day, S., Pacileo, G., et al (2013). Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 61(14), 1527-1535. [More Information]
  • Gray, B., Ingles, J., Medi, C., Semsarian, C. (2013). Prolongation of the QTc Interval Predicts Appropriate Implantable Cardioverter-Defibrillator Therapies in Hypertrophic Cardiomyopathy. JACC: Heart Failure, 1(2), 149-155. [More Information]
  • Ingles, J., Sarina, T., Kasparian, N., Semsarian, C. (2013). Psychological wellbeing and posttraumatic stress associated with implantable cardioverter defibrillator therapy in young adults with genetic heart disease. International Journal of Cardiology, 168(4), 3779-3784. [More Information]
  • Ingles, J., Semsarian, C. (2013). The Australian Genetic Heart Disease Registry. International Journal of Cardiology, 168(4), e127-e128. [More Information]
  • Padang, R., Bannon, P., Jeremy, R., Richmond, D., Semsarian, C., Vallely, M., Wilson, M., Yan, T. (2013). The genetic and molecular basis of bicuspid aortic valve associated thoracic aortopathy: a link to phenotype heterogeneity. Annals of Cardiothoracic Surgery, 2(1), 83-91. [More Information]
  • Offen, S., Celermajer, D., Semsarian, C., Puranik, R. (2013). The role of diastolic filling in preserving left ventricular stroke volume - An MRI study. International Journal of Cardiology, 168(2), 1596-1598. [More Information]
  • Redfern, J., Ingles, J., Neubeck, A., Johnston, S., Semsarian, C. (2013). Tweeting Our Way to Cardiovascular Health. Journal of the American College of Cardiology, 61(15), 1657-1658. [More Information]
  • Alsheikh-Ali, A., Link, M., Semsarian, C., Shen, W., Mark Estes lll, N., Maron, M., Haas, T., Formisano, F., Boriani, G., Spirito, P., et al (2013). Ventricular tachycardia/fibrillation early after defibrillator implantation in patients with hypertrophic cardiomyopathy is explained by a high-risk subgroup of patients. Heart Rhythm, 10(2), 214-218. [More Information]
  • Ingles, J., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2012). A cost-effectiveness model of genetic testing for the evaluation of families with hypertrophic cardiomyopathy. Heart, 98(8), 625-630. [More Information]
  • Watts, G., Sullivan, D., van Bockxmeer, F., Poplawski, N., Hamilton-Craig, I., Clifton, P., O'Brien, R., Bishop, W., George, P., Semsarian, C., et al (2012). A New Model of Care for Familial Hypercholesterolaemia: What is the Role of Cardiology? Heart, Lung and Circulation, 21(9), 543-550. [More Information]
  • Gray, B., Das K, J., Semsarian, C. (2012). Consumption of energy drinks: A new provocation test for primary arrhythmogenic diseases? International Journal of Cardiology, 159(1), 77-78. [More Information]
  • Maron, B., Maron, M., Semsarian, C. (2012). Double or compound sarcomere mutations in hypertrophic cardiomyopathy: a potential link to sudden death in the absence of conventional risk factors. Heart Rhythm, 9(1), 57-63. [More Information]
  • Padang, R., Bagnall, R., Semsarian, C. (2012). Genetic Basis of Familial Valvular Heart Disease. Circulation: Cardiovascular Genetics, 5(5), 569-580. [More Information]
  • Ingles, J., Yeates, L., O'Brien, L., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2012). Genetic testing for inherited heart diseases: longitudinal impact on health-related quality of life. Genetics in Medicine, 14(8), 749-752. [More Information]
  • Maron, B., Maron, M., Semsarian, C. (2012). Genetics of hypertrophic cardiomyopathy after 20 years: clinical perspectives. Journal of the American College of Cardiology, 60(8), 705-715. [More Information]
  • Bagnall, R., Tsoutsman, T., Shephard, R., Ritchie, W., Semsarian, C. (2012). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PloS One, 7(9), 1-8. [More Information]
  • Semsarian, C., Hamilton, R. (2012). Key role of the molecular autopsy in sudden unexpected death. Heart Rhythm, 9(1), 145-150. [More Information]
  • Maron, B., Semsarian, C. (2012). Prevention of sudden death for patients with cardiomyopathies another step forward. Journal of the American College of Cardiology, 59(5), 501-502. [More Information]
  • Padang, R., Bagnall, R., Richmond, D., Bannon, P., Semsarian, C. (2012). Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease. Journal of Molecular and Cellular Cardiology, 53(2), 277-281. [More Information]
  • Kelly, M., Bagnall, R., Peverill, R., Donelan, L., Corben, L., Delatycki, M., Semsarian, C. (2011). A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Journal of Molecular and Cellular Cardiology, 51(5), 848-854. [More Information]
  • Vohra, J., Skinner, J., Semsarian, C. (2011). Cardiac Genetic Investigation of Young Sudden Unexplained Death and Resuscitated Out of Hospital Cardiac Arrest. Heart, Lung and Circulation, 20(12), 746-750. [More Information]
  • Maron, B., Yeates, L., Semsarian, C. (2011). Clinical challenges of genotype positive (+)phenotype negative (-) family members in hypertrophic cardiomyopathy. The American Journal of Cardiology, 107(4), 604-608. [More Information]
  • Eshoo, S., Semsarian, C., Ross, D., Marwick, T., Thomas, L. (2011). Comparison of Left Atrial Phasic Function in Hypertrophic Cardiomyopathy Versus Systemic Hypertension Using Strain Rate Imaging. The American Journal of Cardiology, 107(2), 290-296. [More Information]
  • Tu, E., Waterhouse, L., Duflou, J., Bagnall, R., Semsarian, C. (2011). Genetic Analysis of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels in Sudden Unexpected in Epilepsy Cases. Brain Pathology, 21(6), 692-698. [More Information]
  • Maron, B., Ahluwalia, A., Haas, T., Semsarian, C., Link, M., Estes, N. (2011). Global epidemiology and demographics of commotio cordis. Heart Rhythm, 8(12), 1969-1971. [More Information]
  • Ingles, J., Zodgekar, P., Yeates, L., Macciocca, I., Semsarian, C., Fatkin, D., Members of CSANZ Cardiac Genetic Diseases Council Writing Group, M. (2011). Guidelines for genetic testing of inherited cardiac disorders. Heart, Lung and Circulation, 20(11), 681-687. [More Information]
  • Semsarian, C., Members of CSANZ Cardiac Genetic Diseases Council Writing Group, M. (2011). Guidelines for the diagnosis and management of hypertrophic cardiomyopathy. Heart, Lung and Circulation, 20(11), 688-690. [More Information]
  • Ackerman, M., Priori, S., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A., Ellinor, P., Gollob, M., et al, Semsarian, C. (2011). HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies. Europace, 13(8), 1077-1109. [More Information]
  • Gray, B., Semsarian, C., Sy, R., Jeremy, R. (2011). Left coronary artery fistula after septal myectomy in hypertrophic cardiomyopathy. Heart, Lung and Circulation, 20(11), 738-738. [More Information]
  • Bagnall, R., Ingles, J., Semsarian, C. (2011). Molecular diagnostics of cardiomyopathies: the future is here. Circulation Cardiovascular Genetics, 4(2), 103-104. [More Information]
  • Gray, B., Ingles, J., Semsarian, C. (2011). Natural history of genotype positive-phenotype negative patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 152(2), 258-259. [More Information]
  • Ng, D., Ng, I., Yeap, Y., Badrain, B., Tsoutsman, T., McMullen, J., Semsarian, C., Bogoyevitch, M. (2011). Opposing Actions of Extracellular Signal-Regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy. Journal of Biological Chemistry, 286(2), 1576-1587. [More Information]
  • Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D., et al (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9. [More Information]
  • Ingles, J., Yeates, L., Semsarian, C. (2011). The emerging role of the cardiac genetic counselor. Heart Rhythm, 8(12), 1958-1962. [More Information]
  • Qian, L., Wythe, J., Liu, J., Cartry, J., Vogler, G., Mohapatra, B., Otway, R., Huang, Y., King, I., Maillet, M., Semsarian, C., Winlaw, D., et al (2011). Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology, 193(7), 1181-1196. [More Information]
  • Bagnall, R., Yeates, L., Semsarian, C. (2010). Analysis of the Z-disc genes PDLIM3 and MYPN in Patients with Hypertrophic Cardiomyopathy. International Journal of Cardiology, 145(3), 601-2. [More Information]
  • Girolami, F., Ho, C., Semsarian, C., Baldi, M., Will, M., Baldini, K., Torricelli, F., Yeates, L., Cecchi, F., Ackerman, M., et al (2010). Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. Journal of the American College of Cardiology, 55(14), 1444-1453. [More Information]
  • Lam, L., Tsoutsman, T., Arthur, J., Semsarian, C. (2010). Differential protein expression profiling of myocardial tissue in a mouse model of hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 48(5), 1014-1022. [More Information]
  • Maron, B., Semsarian, C. (2010). Emergence of gene mutation carriers and the expanding disease spectrum of hypertrophic cardiomyopathy. European heart journal, 31(13), 1551-1553. [More Information]
  • Eshoo, S., Semsarian, C., Ross, D., Thomas, L. (2010). Left Atrial Phasic Volumes Are Modulated by the Type Rather Than the Extent of Left Ventricular Hypertrophy. Journal of the American Society of Echocardiography, 23(5), 538-544. [More Information]
  • Chiu, C., Bagnall, R., Ingles, J., Yeates, L., Kennerson, M., Donald, J., Jormakka, M., Lind, J., Semsarian, C. (2010). Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy: A Genome-Wide Analysis. Journal of the American College of Cardiology, 55(11), 1127-1135. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Lynch, M., Twigg, S., Semsarian, C. (2010). Post-mortem pathologic and genetic studies in "dead in bed syndrome" cases in type 1 diabetes mellitus. Human Pathology, 41(3), 392-400. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Semsarian, C. (2010). Post-Mortem Review and Genetic Analysis of Sudden Unexpected Death in Epilepsy (SUDEP) Cases. Brain Pathology, , 1-8. [More Information]
  • Tu, E., Twigg, S., Semsarian, C. (2010). Sudden death in type 1 diabetes: The mystery of the 'dead in bed' syndrome. International Journal of Cardiology, 138(1), 91-93. [More Information]
  • Shepard, R., Semsarian, C. (2009). Advances in the prevention of sudden cardiac death in the young. Therapeutic Advances in Cardiovascular Disease, 3(2), 145-155. [More Information]
  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009). Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American Journal of Physiology: Cell Physiology, 297(6), c1490-c1500. [More Information]
  • Maron, B., Semsarian, C., Shen, W., Link, M., Epstein, A., Estes, N., Almquist, A., Giudici, M., Haas, T., Hodges, J., et al (2009). Circadian patterns in the occurrence of malignant ventricular tachyarrhythmias triggering defibrillator interventions in patients with hypertrophic cardiomyopathy. Heart Rhythm, 6(5), 599-602. [More Information]
  • Kelly, M., Semsarian, C. (2009). Multiple mutations in genetic cardiovascular disease: a marker of disease severity? Circulation: Cardiovascular Genetics, 2(2), 182-190. [More Information]
  • Wilcox, I., Semsarian, C. (2009). Obstructive sleep apnea a respiratory syndrome with protean cardiovascular manifestations. Journal of the American College of Cardiology, 54(19), 1810-1812. [More Information]
  • Sherrid, M., Cotiga, D., Hart, D., Ehlert, F., Haas, T., Shen, W., Link, M., Estes, N., Epstein, A., et al, Semsarian, C. (2009). Relation of 12-lead electrocardiogram patterns to implanted defibrillator-terminated ventricular tachyarrhythmias in hypertrophic cardiomyopathy. The American Journal of Cardiology, 104(12), 1722-1726. [More Information]
  • Shephard, R., Semsarian, C. (2009). Role of animal models in HCM research. Journal of Cardiovascular Translational Research, 2(4), 471-482. [More Information]
  • Bagnall, R., Yeates, L., Semsarian, C. (2009). The role of large gene deletions and duplications in MYBPC3 and TNNT2 in patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 145, 150-3. [More Information]
  • Semsarian, C. (2009). Use of mouse models for the analysis of human disease. Current Protocols in Human Genetics, , 15.2.1-15.2.10. [More Information]
  • Tu, E., Twigg, S., Duflou, J., Semsarian, C. (2008). Causes of death in young Australians with type 1 diabetes: a review of coronial postmortem examinations. Medical Journal of Australia, 188(12), 699-702. [More Information]
  • Ingles, J., McGaughran, J., Vohra, J., Weintraub, R., Davis, A., Atherton, J., Semsarian, C. (2008). Establishment of an Australian National Genetic Heart Disease Registry. Heart, Lung and Circulation, 17(6), 463-467. [More Information]
  • Tsoutsman, T., Bagnall, R., Semsarian, C. (2008). Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure. Clinical and Experimental Pharmacology and Physiology, 35(11), 1349-1357. [More Information]
  • Vallely, M., Semsarian, C., Bannon, P. (2008). Management of the Ascending Aorta in Patients with Bicuspid Aortic Valve Disease. Heart, Lung and Circulation, 17(5), 357-363. [More Information]
  • Doolan, A., Langlois, N., Chiu, C., Ingles, J., Lind, J., Semsarian, C. (2008). Postmortem molecular analysis of KCNQ1 and SCN5A genes in sudden unexplained death in young Australians. International Journal of Cardiology, 127, 138-141. [More Information]
  • Ingles, J., Lind, J., Phongsavan, P., Semsarian, C. (2008). Psychosocial impact of specialized cardiac genetic clinics for hypertrophic cardiomyopathy. Genetics in Medicine, 10(2), 117-120. [More Information]
  • Skinner, J., Duflou, J., Semsarian, C. (2008). Reducing sudden death in young people in Australia and New Zealand: The TRAGADY initiative. Medical Journal of Australia, 189(10), 539-540. [More Information]
  • Tsoutsman, T., Kelly, M., Ng, D., Tan, J., Tu, E., Lien, L., Bogoyevitch, M., Seidman, C., Seidman, J., Semsarian, C. (2008). Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation, 117(14), 1820-1831. [More Information]
  • Lind, J., Chiu, C., Ingles, J., Yeates, L., Humphries, S., Heather, A., Semsarian, C. (2008). Sex hormone receptor gene variation associated with phenotype in male hypertrophic cardiomyopathy patients. Journal of Molecular and Cellular Cardiology, 45(2), 217-222. [More Information]
  • Chiu, C., Tebo, M., Ingles, J., Yeates, L., Arthur, J., Lind, J., Semsarian, C. (2007). Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 43, 337-343. [More Information]
  • Semsarian, C. (2007). Guidelines for the Diagnosis and Management of Hypertrophic Cardiomyopathy. Heart, Lung and Circulation, 16(1), 16-18. [More Information]
  • Maron, B., Spirito, P., Shen, W., Haas, T., Formisano, F., Link, M., Epstein, A., Almquist, A., Daubert, J., Lawrenz, T., Semsarian, C., et al (2007). Implantable Cardioverter-Defibrillators and Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathy. JAMA: The Journal of the American Medical Association, 298(4), 405-412. [More Information]
  • Lam, L., Arthur, J., Semsarian, C. (2007). Proteome map of the normal murine ventricular myocardium. Proteomics, 7(19), 3629-3633. [More Information]
  • Ingles, J., Semsarian, C. (2007). Sudden cardiac death in the young: a clinical genetic approach. Internal Medicine Journal, 37(1), 32-37. [More Information]
  • Nguyen, L., Chung, J., Lam, L., Tsoutsman, T., Semsarian, C. (2006). Abnormal cardiac response to exercise in a murine model of familial hypertrophic cardiomyopathy. International Journal of Cardiology, , 1-4. [More Information]
  • Lam, L., Lind, J., Semsarian, C. (2006). Application of proteomics in cardiovascular medicine. International Journal of Cardiology, 108(1), 12-19. [More Information]
  • Tsoutsman, T., Lam, L., Semsarian, C. (2006). Genes, calcium and modifying factors in hypertrophic cardiomyopathy. Clinical and Experimental Pharmacology and Physiology, 33, 139-145. [More Information]
  • Lind, J., Chiu, C., Semsarian, C. (2006). Genetic basis of hypertrophic cardiomyopathy. Expert Review of Cardiovascular Therapy, 4(6), 927-934. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Bailey, C., Rasko, J., Allen, D., Semsarian, C. (2006). Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 41(4), 623-632. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Rasko, J., Bailey, C., Allen, D., Semsarian, C. (2006). Mouse cardiac troponin I model of hypertrophic cardiomyopathy: Phenotype associated with abnormal calcium handling. Journal of Molecular and Cellular Cardiology, 41(4), 747 (abstract 41)-747.
  • Chiu, C., Ingles, J., Lind, J., Semsarian, C. (2006). Mutation analysis of the natriuretic peptide precursor B (NPPB) gene in patients with hypertrophic cardiomyopathy. DNA Sequence, 17(5), 392-395. [More Information]
  • Lind, J., Semsarian, C. (2006). Overview of model systems for the analysis of human disease. Current Protocols in Human Genetics, , Unit 15.1. [More Information]
  • Herron, B., Rao, C., Liu, S., Laprade, L., Richardson, J., Oliveri, E., Semsarian, C., Millar, S., Stubbs, L., Beier, D. (2005). A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Human Molecular Genetics, 14(5), 667-677. [More Information]
  • Doolan, A., Tebo, M., Ingles, J., Nguyen, L., Tsoutsman, T., Lam, L., Chiu, C., Chung, J., Weintraub, R., Semsarian, C. (2005). Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. Journal of Molecular and Cellular Cardiology, 38(2), 387-93. [More Information]
  • Ingles, J., Doolan, A., Chiu, C., Seidman, J., Seidman, C., Semsarian, C. (2005). Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. Journal of Medical Genetics, 42(10), 1-6. [More Information]
  • Megevand, A., Ingles, J., Richmond, D., Semsarian, C. (2005). Long-term follow-up of patients with obstructive hypertrophic cardiomyopathy treated with dual-chamber pacing. The American Journal of Cardiology, 95(8), 991-993. [More Information]
  • Wolf, C., Moskowitz, I., Arno, S., Branco, D., Semsarian, C., Bernstein, S., Peterson, M., Maida, M., Morley, G., Fishman, G., et al (2005). Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 102(50), 18123-18128. [More Information]
  • Doolan, A., Langlois, N., Semsarian, C. (2004). Causes Of Sudden Cardiac Death In Young Australians. Medical Journal of Australia, 180(3), 110-112.
  • Doolan, A., Nguyen, L., Semsarian, C. (2004). Hypertrophic Cardiomyopathy: From "Heart Tumour" To A Complex Molecular Genetic Disorder. Heart, Lung and Circulation, 13(1), 15-25.
  • Jayatilleke, I., Doolan, A., Ingles, J., McGuire, M., Booth, V., Richmond, D., Semsarian, C. (2004). Long-Term Follow-Up Of Implantable Cardioverter Defibrillator Therapy For Hypertrophic Cardiomyopathy. The American Journal of Cardiology, 93(9), 1192-1194. [More Information]
  • Doolan, G., Nguyen, L., Chung, J., Ingles, J., Semsarian, C. (2004). Progression Of Left Ventricular Hypertrophy And The Angiotensin-Converting Enzyme Gene Polymorphism In Hypertrophic Cardiomyopathy. International Journal of Cardiology, 96(2), 157-163.
  • Schmitt, J., Semsarian, C., Arad, M., Gannon, J., Ahmad, F., Duffy, C., Lee, R., Seidman, C., Seidman, J. (2003). Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomypathy. Circulation, 108(9), 1133-1138.
  • Chung, M., Tsoutsman, T., Semsarian, C. (2003). Hypertrophic cardiomyopathy: from gene defect to clinical disease. Cell Research, 13(1), 9-20.
  • Jayatilleke, I., McGuire, M., Booth, V., Richmond, D., Semsarian, C. (2003). Sudden death prevented in hypertrophic cardiomyopathy. Heart, Lung and Circulation, 12(3), 196-198.
  • Semsarian, C. (2002). Stem cells in cardiovascular disease: from cell biology to clinical therapy. Internal Medicine Journal, 32(5-6), 259-265.

Conferences

  • Neubeck, A., Lowres, N., Semsarian, C., Ingles, J., Johnston, S., Redfern, J. (2012). Social Media and Cardiac Rehabilitation: A Systematic Review. 22nd Australian Cardiovascular Health and Rehabilitation Association (ACRA) Annual Conference 2012, Brisbane, Queensland, Australia.
  • Ingles, J., Doolan, A., Chiu, C., Seidman, J., Seidman, C., Semsarian, C. (2005). Compound and double mutations in hypertrophic cardiomyopathy patients: Implications for genetic testing and counselling. American Heart Association Annual Scientific Sessions 2005, United States: American Heart Association.

2014

  • Burns, C., Semsarian, C., Ingles, J. (2014). Access, uptake and communication of genetic test results in Australian families with long QT syndrome (LQTS). Heart, Lung and Circulation, 23(S2), e7.
  • Gray, B., Semsarian, C., Sy, R. (2014). Brugada Syndrome: A Heterogeneous Disease with a Common ECG Phenotype? Journal of Cardiovascular Electrophysiology, 25(4), 450-456. [More Information]
  • Driscoll, E., Ingles, J., Semsarian, C. (2014). Clinical and genetic characteristics of hypertrophic cardiomyopathy patients with end-stage disease: A registry-based study. Heart, Lung and Circulation, 23(S2), e8-e9.
  • Puranik, R., Gray, B., Lackey, H., Duflou, J., Yeates, L., Parker, G., Semsarian, C. (2014). Comparison of conventional autopsy and magnetic resonance imaging in determining the cause of sudden death in the young. Journal of Cardiovascular Magnetic Resonance, 16(1), 1-11. [More Information]
  • Ingles, J., Semsarian, C. (2014). Conveying a probabilistic genetic test result to families with an inherited heart disease. Heart Rhythm, 11(6), 1073-1078. [More Information]
  • Padang, R., Dennis, M., Semsarian, C., Bannon, P., Tanous, D., Celermajer, D., Puranik, R. (2014). Detection of Serious Complications by MR Imaging in Asymptomatic Young Adults with Repaired Coarctation of the Aorta. Heart, Lung and Circulation, 23(4), 332-338. [More Information]
  • Das K, J., Ingles, J., Bagnall, R., Semsarian, C. (2014). Determining pathogenicity of genetic variants in hypertrophic cardiomyopathy: importance of periodic reassessment. Genetics in Medicine, 16(4), 286-293. [More Information]
  • Bagnall, R., Das K, J., Duflou, J., Semsarian, C. (2014). Exome analysis–based molecular autopsy in cases of sudden unexplained death in the young. Heart Rhythm, 11(4), 655-662. [More Information]
  • Bagnall, R., Crompton, D., Cutmore, C., Regan, B., Scheffer, I., Semsarian, C. (2014). Genetic analysis of PHOX2B in sudden unexpected death in epilepsy cases. Neurology, 83(11), 1018-1021. [More Information]
  • Brunklaus, A., Ellis, R., Reavey, E., Semsarian, C., Zuberi, S. (2014). Genotype phenotype associations across the voltage-gated sodium channel family. Journal of Medical Genetics, 51, 650-658. [More Information]
  • Maron, B., Ommen, S., Semsarian, C., Spirito, P., Olivotto, I., Maron, M. (2014). Hypertrophic cardiomyopathy: Present and future, with translation into contemporary cardiovascular medicine. Journal of the American College of Cardiology, 64(1), 83-99. [More Information]
  • Bagnall, R., Ingles, J., Semsarian, C. (2014). Illumina TruSight Cardiomyopathy Sequencing Panel: Application to hypertrophic cardiomyopathy. Heart, Lung and Circulation, 23(S2), e5.
  • Femia, G., Hsu, C., Singarayar, S., Sy, R., Kilborn, M., Parker, G., McGuire, M., Semsarian, C., Puranik, R. (2014). Impact of new task force criteria in the diagnosis of arrhythmogenic right ventricular cardiomyopathy. International Journal of Cardiology, 171(2), 179-183. [More Information]
  • Gray, B., McGuire, M., Semsarian, C., Medi, C. (2014). Late positive flecainide challenge test for Brugada syndrome. Heart Rhythm, 11(5), 898-900. [More Information]
  • Spirito, P., Autore, C., Formisano, F., Gabriele, E., Biagini, E., Haas, T., Bongioanni, S., Semsarian, C., Devoto, E., Yeates, L., et al (2014). Risk of sudden death and outcome in patients with hypertrophic cardiomyopathy with benign presentation and without risk factors. The American Journal of Cardiology, 113(9), 1550-1555. [More Information]
  • Semsarian, C., Sweeting, J., Ingles, J. (2014). Sudden death in athletes: Preventable or inevitable? Heart Rhythm, 11(10), 682-683. [More Information]
  • Ingles, J., Semsarian, C. (2014). The value of cardiac genetic testing. Trends In Cardiovascular Medicine, 24(6), 217-224. [More Information]

2013

  • Tsoutsman, T., Wang, X., Garchow, K., Riser, B., Twigg, S., Semsarian, C. (2013). CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. Journal of Molecular and Cellular Cardiology, 62, 164-178. [More Information]
  • Ingles, J., Sarina, T., Yeates, L., Hunt, L., Macciocca, I., McCormack, L., Winship, I., McGaughran, J., Atherton, J., Semsarian, C. (2013). Clinical predictors of genetic testing outcomes in hypertrophic cardiomyopathy. Genetics in Medicine, 15(12), 972-977. [More Information]
  • Semsarian, C., Ingles, J. (2013). Expanding the genetic spectrum of hypertrophic cardiomyopathy: x marks the spot. Circulation Cardiovascular Genetics, 6(6), 528-530. [More Information]
  • Costa, M., Guo, G., Wolstein, O., Vale, M., Castro, M., Wang, L., Otway, R., Riek, R., Cochrane, N., Furtado, M., Semsarian, C., et al (2013). Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy. Circulation Cardiovascular Genetics, 6(3), 238-247. [More Information]
  • Ingles, J., Yeates, L., Hunt, L., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2013). Health status of cardiac genetic disease patients and their at-risk relatives. International Journal of Cardiology, 165(3), 448-453. [More Information]
  • Gray, B., Yeates, L., Medi, C., Ingles, J., Semsarian, C. (2013). Homozygous mutation in the cardiac troponin I gene: Clinical heterogeneity in hypertrophic cardiomyopathy. International Journal of Cardiology, 168(2), 1530-1531. [More Information]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology: cellular and molecular biology of disease, 183(3), 745-757. [More Information]
  • Figtree, G., Bagnall, R., Abdulla, I., Buchholz, S., Karimi Galougahi, K., Yan, W., Tan, T., Neil, C., Horowitz, J., Semsarian, C., Ward, M. (2013). No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. European Journal of Heart Failure, 15(7), 730-733. [More Information]
  • Semsarian, C., Weintraub, R. (2013). Paediatric cardiomyopathy: Getting to the heart of the matter. The Lancet, 382(9908), 1866-1867. [More Information]
  • Yeates, L., Hunt, L., Saleh, M., Semsarian, C., Ingles, J. (2013). Poor psychological wellbeing particularly in mothers following sudden cardiac death in the young. European Journal of Cardiovascular Nursing, 12(5), 484-491. [More Information]
  • Sweeting, J., Duflou, J., Semsarian, C. (2013). Postmortem analysis of cardiovascular deaths in schizophrenia: A 10-year review. Schizophrenia Research, 150(2-3), 398-403. [More Information]
  • Evans, A., Bagnall, R., Duflou, J., Semsarian, C. (2013). Postmortem review and genetic analysis in sudden infant death syndrome: an 11-year review. Human Pathology, 44(9), 1730-1736. [More Information]
  • Maron, B., Spirito, P., Ackerman, M., Casey, S., Semsarian, C., Estes, N., Shannon, K., Ashley, E., Day, S., Pacileo, G., et al (2013). Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 61(14), 1527-1535. [More Information]
  • Gray, B., Ingles, J., Medi, C., Semsarian, C. (2013). Prolongation of the QTc Interval Predicts Appropriate Implantable Cardioverter-Defibrillator Therapies in Hypertrophic Cardiomyopathy. JACC: Heart Failure, 1(2), 149-155. [More Information]
  • Ingles, J., Sarina, T., Kasparian, N., Semsarian, C. (2013). Psychological wellbeing and posttraumatic stress associated with implantable cardioverter defibrillator therapy in young adults with genetic heart disease. International Journal of Cardiology, 168(4), 3779-3784. [More Information]
  • Ingles, J., Semsarian, C. (2013). The Australian Genetic Heart Disease Registry. International Journal of Cardiology, 168(4), e127-e128. [More Information]
  • Padang, R., Bannon, P., Jeremy, R., Richmond, D., Semsarian, C., Vallely, M., Wilson, M., Yan, T. (2013). The genetic and molecular basis of bicuspid aortic valve associated thoracic aortopathy: a link to phenotype heterogeneity. Annals of Cardiothoracic Surgery, 2(1), 83-91. [More Information]
  • Offen, S., Celermajer, D., Semsarian, C., Puranik, R. (2013). The role of diastolic filling in preserving left ventricular stroke volume - An MRI study. International Journal of Cardiology, 168(2), 1596-1598. [More Information]
  • Redfern, J., Ingles, J., Neubeck, A., Johnston, S., Semsarian, C. (2013). Tweeting Our Way to Cardiovascular Health. Journal of the American College of Cardiology, 61(15), 1657-1658. [More Information]
  • Alsheikh-Ali, A., Link, M., Semsarian, C., Shen, W., Mark Estes lll, N., Maron, M., Haas, T., Formisano, F., Boriani, G., Spirito, P., et al (2013). Ventricular tachycardia/fibrillation early after defibrillator implantation in patients with hypertrophic cardiomyopathy is explained by a high-risk subgroup of patients. Heart Rhythm, 10(2), 214-218. [More Information]

2012

  • Ingles, J., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2012). A cost-effectiveness model of genetic testing for the evaluation of families with hypertrophic cardiomyopathy. Heart, 98(8), 625-630. [More Information]
  • Watts, G., Sullivan, D., van Bockxmeer, F., Poplawski, N., Hamilton-Craig, I., Clifton, P., O'Brien, R., Bishop, W., George, P., Semsarian, C., et al (2012). A New Model of Care for Familial Hypercholesterolaemia: What is the Role of Cardiology? Heart, Lung and Circulation, 21(9), 543-550. [More Information]
  • Gray, B., Das K, J., Semsarian, C. (2012). Consumption of energy drinks: A new provocation test for primary arrhythmogenic diseases? International Journal of Cardiology, 159(1), 77-78. [More Information]
  • Maron, B., Maron, M., Semsarian, C. (2012). Double or compound sarcomere mutations in hypertrophic cardiomyopathy: a potential link to sudden death in the absence of conventional risk factors. Heart Rhythm, 9(1), 57-63. [More Information]
  • Padang, R., Bagnall, R., Semsarian, C. (2012). Genetic Basis of Familial Valvular Heart Disease. Circulation: Cardiovascular Genetics, 5(5), 569-580. [More Information]
  • Ingles, J., Yeates, L., O'Brien, L., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2012). Genetic testing for inherited heart diseases: longitudinal impact on health-related quality of life. Genetics in Medicine, 14(8), 749-752. [More Information]
  • Maron, B., Maron, M., Semsarian, C. (2012). Genetics of hypertrophic cardiomyopathy after 20 years: clinical perspectives. Journal of the American College of Cardiology, 60(8), 705-715. [More Information]
  • Bagnall, R., Tsoutsman, T., Shephard, R., Ritchie, W., Semsarian, C. (2012). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PloS One, 7(9), 1-8. [More Information]
  • Semsarian, C., Hamilton, R. (2012). Key role of the molecular autopsy in sudden unexpected death. Heart Rhythm, 9(1), 145-150. [More Information]
  • Maron, B., Semsarian, C. (2012). Prevention of sudden death for patients with cardiomyopathies another step forward. Journal of the American College of Cardiology, 59(5), 501-502. [More Information]
  • Padang, R., Bagnall, R., Richmond, D., Bannon, P., Semsarian, C. (2012). Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease. Journal of Molecular and Cellular Cardiology, 53(2), 277-281. [More Information]
  • Neubeck, A., Lowres, N., Semsarian, C., Ingles, J., Johnston, S., Redfern, J. (2012). Social Media and Cardiac Rehabilitation: A Systematic Review. 22nd Australian Cardiovascular Health and Rehabilitation Association (ACRA) Annual Conference 2012, Brisbane, Queensland, Australia.

2011

  • Kelly, M., Bagnall, R., Peverill, R., Donelan, L., Corben, L., Delatycki, M., Semsarian, C. (2011). A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Journal of Molecular and Cellular Cardiology, 51(5), 848-854. [More Information]
  • Vohra, J., Skinner, J., Semsarian, C. (2011). Cardiac Genetic Investigation of Young Sudden Unexplained Death and Resuscitated Out of Hospital Cardiac Arrest. Heart, Lung and Circulation, 20(12), 746-750. [More Information]
  • Maron, B., Yeates, L., Semsarian, C. (2011). Clinical challenges of genotype positive (+)phenotype negative (-) family members in hypertrophic cardiomyopathy. The American Journal of Cardiology, 107(4), 604-608. [More Information]
  • Eshoo, S., Semsarian, C., Ross, D., Marwick, T., Thomas, L. (2011). Comparison of Left Atrial Phasic Function in Hypertrophic Cardiomyopathy Versus Systemic Hypertension Using Strain Rate Imaging. The American Journal of Cardiology, 107(2), 290-296. [More Information]
  • Tu, E., Waterhouse, L., Duflou, J., Bagnall, R., Semsarian, C. (2011). Genetic Analysis of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels in Sudden Unexpected in Epilepsy Cases. Brain Pathology, 21(6), 692-698. [More Information]
  • Maron, B., Ahluwalia, A., Haas, T., Semsarian, C., Link, M., Estes, N. (2011). Global epidemiology and demographics of commotio cordis. Heart Rhythm, 8(12), 1969-1971. [More Information]
  • Ingles, J., Zodgekar, P., Yeates, L., Macciocca, I., Semsarian, C., Fatkin, D., Members of CSANZ Cardiac Genetic Diseases Council Writing Group, M. (2011). Guidelines for genetic testing of inherited cardiac disorders. Heart, Lung and Circulation, 20(11), 681-687. [More Information]
  • Semsarian, C., Members of CSANZ Cardiac Genetic Diseases Council Writing Group, M. (2011). Guidelines for the diagnosis and management of hypertrophic cardiomyopathy. Heart, Lung and Circulation, 20(11), 688-690. [More Information]
  • Ackerman, M., Priori, S., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A., Ellinor, P., Gollob, M., et al, Semsarian, C. (2011). HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies. Europace, 13(8), 1077-1109. [More Information]
  • Gray, B., Semsarian, C., Sy, R., Jeremy, R. (2011). Left coronary artery fistula after septal myectomy in hypertrophic cardiomyopathy. Heart, Lung and Circulation, 20(11), 738-738. [More Information]
  • Bagnall, R., Ingles, J., Semsarian, C. (2011). Molecular diagnostics of cardiomyopathies: the future is here. Circulation Cardiovascular Genetics, 4(2), 103-104. [More Information]
  • Gray, B., Ingles, J., Semsarian, C. (2011). Natural history of genotype positive-phenotype negative patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 152(2), 258-259. [More Information]
  • Ng, D., Ng, I., Yeap, Y., Badrain, B., Tsoutsman, T., McMullen, J., Semsarian, C., Bogoyevitch, M. (2011). Opposing Actions of Extracellular Signal-Regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy. Journal of Biological Chemistry, 286(2), 1576-1587. [More Information]
  • Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D., et al (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9. [More Information]
  • Ingles, J., Yeates, L., Semsarian, C. (2011). The emerging role of the cardiac genetic counselor. Heart Rhythm, 8(12), 1958-1962. [More Information]
  • Qian, L., Wythe, J., Liu, J., Cartry, J., Vogler, G., Mohapatra, B., Otway, R., Huang, Y., King, I., Maillet, M., Semsarian, C., Winlaw, D., et al (2011). Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology, 193(7), 1181-1196. [More Information]

2010

  • Bagnall, R., Yeates, L., Semsarian, C. (2010). Analysis of the Z-disc genes PDLIM3 and MYPN in Patients with Hypertrophic Cardiomyopathy. International Journal of Cardiology, 145(3), 601-2. [More Information]
  • Girolami, F., Ho, C., Semsarian, C., Baldi, M., Will, M., Baldini, K., Torricelli, F., Yeates, L., Cecchi, F., Ackerman, M., et al (2010). Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. Journal of the American College of Cardiology, 55(14), 1444-1453. [More Information]
  • Lam, L., Tsoutsman, T., Arthur, J., Semsarian, C. (2010). Differential protein expression profiling of myocardial tissue in a mouse model of hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 48(5), 1014-1022. [More Information]
  • Maron, B., Semsarian, C. (2010). Emergence of gene mutation carriers and the expanding disease spectrum of hypertrophic cardiomyopathy. European heart journal, 31(13), 1551-1553. [More Information]
  • Eshoo, S., Semsarian, C., Ross, D., Thomas, L. (2010). Left Atrial Phasic Volumes Are Modulated by the Type Rather Than the Extent of Left Ventricular Hypertrophy. Journal of the American Society of Echocardiography, 23(5), 538-544. [More Information]
  • Chiu, C., Bagnall, R., Ingles, J., Yeates, L., Kennerson, M., Donald, J., Jormakka, M., Lind, J., Semsarian, C. (2010). Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy: A Genome-Wide Analysis. Journal of the American College of Cardiology, 55(11), 1127-1135. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Lynch, M., Twigg, S., Semsarian, C. (2010). Post-mortem pathologic and genetic studies in "dead in bed syndrome" cases in type 1 diabetes mellitus. Human Pathology, 41(3), 392-400. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Semsarian, C. (2010). Post-Mortem Review and Genetic Analysis of Sudden Unexpected Death in Epilepsy (SUDEP) Cases. Brain Pathology, , 1-8. [More Information]
  • Tu, E., Twigg, S., Semsarian, C. (2010). Sudden death in type 1 diabetes: The mystery of the 'dead in bed' syndrome. International Journal of Cardiology, 138(1), 91-93. [More Information]

2009

  • Shepard, R., Semsarian, C. (2009). Advances in the prevention of sudden cardiac death in the young. Therapeutic Advances in Cardiovascular Disease, 3(2), 145-155. [More Information]
  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009). Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American Journal of Physiology: Cell Physiology, 297(6), c1490-c1500. [More Information]
  • Maron, B., Semsarian, C., Shen, W., Link, M., Epstein, A., Estes, N., Almquist, A., Giudici, M., Haas, T., Hodges, J., et al (2009). Circadian patterns in the occurrence of malignant ventricular tachyarrhythmias triggering defibrillator interventions in patients with hypertrophic cardiomyopathy. Heart Rhythm, 6(5), 599-602. [More Information]
  • Kelly, M., Semsarian, C. (2009). Multiple mutations in genetic cardiovascular disease: a marker of disease severity? Circulation: Cardiovascular Genetics, 2(2), 182-190. [More Information]
  • Wilcox, I., Semsarian, C. (2009). Obstructive sleep apnea a respiratory syndrome with protean cardiovascular manifestations. Journal of the American College of Cardiology, 54(19), 1810-1812. [More Information]
  • Sherrid, M., Cotiga, D., Hart, D., Ehlert, F., Haas, T., Shen, W., Link, M., Estes, N., Epstein, A., et al, Semsarian, C. (2009). Relation of 12-lead electrocardiogram patterns to implanted defibrillator-terminated ventricular tachyarrhythmias in hypertrophic cardiomyopathy. The American Journal of Cardiology, 104(12), 1722-1726. [More Information]
  • Shephard, R., Semsarian, C. (2009). Role of animal models in HCM research. Journal of Cardiovascular Translational Research, 2(4), 471-482. [More Information]
  • Bagnall, R., Yeates, L., Semsarian, C. (2009). The role of large gene deletions and duplications in MYBPC3 and TNNT2 in patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 145, 150-3. [More Information]
  • Semsarian, C. (2009). Use of mouse models for the analysis of human disease. Current Protocols in Human Genetics, , 15.2.1-15.2.10. [More Information]

2008

  • Tu, E., Twigg, S., Duflou, J., Semsarian, C. (2008). Causes of death in young Australians with type 1 diabetes: a review of coronial postmortem examinations. Medical Journal of Australia, 188(12), 699-702. [More Information]
  • Ingles, J., McGaughran, J., Vohra, J., Weintraub, R., Davis, A., Atherton, J., Semsarian, C. (2008). Establishment of an Australian National Genetic Heart Disease Registry. Heart, Lung and Circulation, 17(6), 463-467. [More Information]
  • Tsoutsman, T., Bagnall, R., Semsarian, C. (2008). Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure. Clinical and Experimental Pharmacology and Physiology, 35(11), 1349-1357. [More Information]
  • Vallely, M., Semsarian, C., Bannon, P. (2008). Management of the Ascending Aorta in Patients with Bicuspid Aortic Valve Disease. Heart, Lung and Circulation, 17(5), 357-363. [More Information]
  • Doolan, A., Langlois, N., Chiu, C., Ingles, J., Lind, J., Semsarian, C. (2008). Postmortem molecular analysis of KCNQ1 and SCN5A genes in sudden unexplained death in young Australians. International Journal of Cardiology, 127, 138-141. [More Information]
  • Ingles, J., Lind, J., Phongsavan, P., Semsarian, C. (2008). Psychosocial impact of specialized cardiac genetic clinics for hypertrophic cardiomyopathy. Genetics in Medicine, 10(2), 117-120. [More Information]
  • Skinner, J., Duflou, J., Semsarian, C. (2008). Reducing sudden death in young people in Australia and New Zealand: The TRAGADY initiative. Medical Journal of Australia, 189(10), 539-540. [More Information]
  • Tsoutsman, T., Kelly, M., Ng, D., Tan, J., Tu, E., Lien, L., Bogoyevitch, M., Seidman, C., Seidman, J., Semsarian, C. (2008). Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation, 117(14), 1820-1831. [More Information]
  • Lind, J., Chiu, C., Ingles, J., Yeates, L., Humphries, S., Heather, A., Semsarian, C. (2008). Sex hormone receptor gene variation associated with phenotype in male hypertrophic cardiomyopathy patients. Journal of Molecular and Cellular Cardiology, 45(2), 217-222. [More Information]

2007

  • Chiu, C., Tebo, M., Ingles, J., Yeates, L., Arthur, J., Lind, J., Semsarian, C. (2007). Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 43, 337-343. [More Information]
  • Semsarian, C. (2007). Guidelines for the Diagnosis and Management of Hypertrophic Cardiomyopathy. Heart, Lung and Circulation, 16(1), 16-18. [More Information]
  • Maron, B., Spirito, P., Shen, W., Haas, T., Formisano, F., Link, M., Epstein, A., Almquist, A., Daubert, J., Lawrenz, T., Semsarian, C., et al (2007). Implantable Cardioverter-Defibrillators and Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathy. JAMA: The Journal of the American Medical Association, 298(4), 405-412. [More Information]
  • Lam, L., Arthur, J., Semsarian, C. (2007). Proteome map of the normal murine ventricular myocardium. Proteomics, 7(19), 3629-3633. [More Information]
  • Ingles, J., Semsarian, C. (2007). Sudden cardiac death in the young: a clinical genetic approach. Internal Medicine Journal, 37(1), 32-37. [More Information]

2006

  • Nguyen, L., Chung, J., Lam, L., Tsoutsman, T., Semsarian, C. (2006). Abnormal cardiac response to exercise in a murine model of familial hypertrophic cardiomyopathy. International Journal of Cardiology, , 1-4. [More Information]
  • Lam, L., Lind, J., Semsarian, C. (2006). Application of proteomics in cardiovascular medicine. International Journal of Cardiology, 108(1), 12-19. [More Information]
  • Tsoutsman, T., Lam, L., Semsarian, C. (2006). Genes, calcium and modifying factors in hypertrophic cardiomyopathy. Clinical and Experimental Pharmacology and Physiology, 33, 139-145. [More Information]
  • Lind, J., Chiu, C., Semsarian, C. (2006). Genetic basis of hypertrophic cardiomyopathy. Expert Review of Cardiovascular Therapy, 4(6), 927-934. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Bailey, C., Rasko, J., Allen, D., Semsarian, C. (2006). Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 41(4), 623-632. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Rasko, J., Bailey, C., Allen, D., Semsarian, C. (2006). Mouse cardiac troponin I model of hypertrophic cardiomyopathy: Phenotype associated with abnormal calcium handling. Journal of Molecular and Cellular Cardiology, 41(4), 747 (abstract 41)-747.
  • Chiu, C., Ingles, J., Lind, J., Semsarian, C. (2006). Mutation analysis of the natriuretic peptide precursor B (NPPB) gene in patients with hypertrophic cardiomyopathy. DNA Sequence, 17(5), 392-395. [More Information]
  • Lind, J., Semsarian, C. (2006). Overview of model systems for the analysis of human disease. Current Protocols in Human Genetics, , Unit 15.1. [More Information]

2005

  • Herron, B., Rao, C., Liu, S., Laprade, L., Richardson, J., Oliveri, E., Semsarian, C., Millar, S., Stubbs, L., Beier, D. (2005). A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Human Molecular Genetics, 14(5), 667-677. [More Information]
  • Doolan, A., Tebo, M., Ingles, J., Nguyen, L., Tsoutsman, T., Lam, L., Chiu, C., Chung, J., Weintraub, R., Semsarian, C. (2005). Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. Journal of Molecular and Cellular Cardiology, 38(2), 387-93. [More Information]
  • Ingles, J., Doolan, A., Chiu, C., Seidman, J., Seidman, C., Semsarian, C. (2005). Compound and double mutations in hypertrophic cardiomyopathy patients: Implications for genetic testing and counselling. American Heart Association Annual Scientific Sessions 2005, United States: American Heart Association.
  • Ingles, J., Doolan, A., Chiu, C., Seidman, J., Seidman, C., Semsarian, C. (2005). Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. Journal of Medical Genetics, 42(10), 1-6. [More Information]
  • Megevand, A., Ingles, J., Richmond, D., Semsarian, C. (2005). Long-term follow-up of patients with obstructive hypertrophic cardiomyopathy treated with dual-chamber pacing. The American Journal of Cardiology, 95(8), 991-993. [More Information]
  • Wolf, C., Moskowitz, I., Arno, S., Branco, D., Semsarian, C., Bernstein, S., Peterson, M., Maida, M., Morley, G., Fishman, G., et al (2005). Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 102(50), 18123-18128. [More Information]

2004

  • Doolan, A., Langlois, N., Semsarian, C. (2004). Causes Of Sudden Cardiac Death In Young Australians. Medical Journal of Australia, 180(3), 110-112.
  • Doolan, A., Nguyen, L., Semsarian, C. (2004). Hypertrophic Cardiomyopathy: From "Heart Tumour" To A Complex Molecular Genetic Disorder. Heart, Lung and Circulation, 13(1), 15-25.
  • Jayatilleke, I., Doolan, A., Ingles, J., McGuire, M., Booth, V., Richmond, D., Semsarian, C. (2004). Long-Term Follow-Up Of Implantable Cardioverter Defibrillator Therapy For Hypertrophic Cardiomyopathy. The American Journal of Cardiology, 93(9), 1192-1194. [More Information]
  • Doolan, G., Nguyen, L., Chung, J., Ingles, J., Semsarian, C. (2004). Progression Of Left Ventricular Hypertrophy And The Angiotensin-Converting Enzyme Gene Polymorphism In Hypertrophic Cardiomyopathy. International Journal of Cardiology, 96(2), 157-163.

2003

  • Schmitt, J., Semsarian, C., Arad, M., Gannon, J., Ahmad, F., Duffy, C., Lee, R., Seidman, C., Seidman, J. (2003). Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomypathy. Circulation, 108(9), 1133-1138.
  • Chung, M., Tsoutsman, T., Semsarian, C. (2003). Hypertrophic cardiomyopathy: from gene defect to clinical disease. Cell Research, 13(1), 9-20.
  • Jayatilleke, I., McGuire, M., Booth, V., Richmond, D., Semsarian, C. (2003). Sudden death prevented in hypertrophic cardiomyopathy. Heart, Lung and Circulation, 12(3), 196-198.

2002

  • Semsarian, C. (2002). Stem cells in cardiovascular disease: from cell biology to clinical therapy. Internal Medicine Journal, 32(5-6), 259-265.

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