Professor Christopher Semsarian

Professor of Medicine
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6195
Fax +61 2 9565 6101

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Research interests

Professor Semsarian is a Molecular Cardiologist with a specific research focus in the molecular basis of cardiovascular disease, in particular, identifying genes that cause disease and elucidating how these gene defects activate signalling pathways leading to disease.

His research interest over the last 10 years has focused on the molecular and genetic basis of cardiovascular disease and specifically, including studies in cardiomyopathies and sudden cardiac death in the young.

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

International links

United States

(Harvard Medical School, Boston) Collaborate on genetic studies in heart disease

Selected grants

2014

  • Practitioner Fellowship Level 2 - Clinical and Genetic Studies in Inherited Heart Diseases and Sudden Death; Semsarian C; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2013

  • Clinical and Genetic Basis of Sudden Unexplained Death in Children; Semsarian C, Weintraub R; Financial Markets Foundation for Children/Research Support.
  • New Gene Discovery in Familial Hypertrophic Cardiomyopathy; Semsarian C, Bagnall R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Genetic testing in children at risk of genetic heart disease: optimizing clinical care; Ingles J, Semsarian C; Thrasher Research Fund/Research Support.
  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Neuro-Cardiac Genetic Basis of Sudden Unexpected Death in Epilepsy; Semsarian C, Crompton D, Bagnall R; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Neuro-Cardiac Genetic Basis of Sudden Unexpected Death in Epilepsy (SUDEP); Semsarian C, Scheffer I; Citizens United for Research in Epilepsy (CURE)/Research Support.
  • Genetic Basis of Valvular Heart Disease; Semsarian C, Weintraub R, Winlaw D, Bagnall R; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Investigation of sudden cardiac death in the young; Semsarian C, Weintraub R, Weintraub R, Duflou J, Puranik R, Skinner J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Key role of connective tissue growth factor (CTGF) in familial cardiomyopathy and heart failure; Semsarian C, Twigg S, Tsoutsman T; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Clinical and Genetic Studies in Inherited Heart Disease and Sudden Death; Semsarian C; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2008

  • Multiple Mutations in Familial Cardiomyopathy: Cahracterisation and Treatment Studies; Tsoutsman T, Semsarian C; Heart Foundation of Australia/Grants-in-Aid.

2007

  • Genetic predisposition to sudden cardiac death in young people with type 1 diabetes; Semsarian C; National Heart Foundation/Research Grants.

2006

  • Novel Insights Into The Genetic Basis Of Hypertrophic Cardiomyopathy: Candidate Genes Related To Calcium (Ca 2+) Handling; Semsarian C; National Heart Foundation/Grants-in-Aid.
  • NHMRC - Practitioner Fellowship; Semsarian C; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2005

  • Genetic basis of sudden cardiac death in the young; Semsarian C; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Molecular studies in hypertrophic cardiomyopathy; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2003

  • Modifying factors and phenotype heterogeneity in familial hypertrophic cardiomyopathy; Semsarian C; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Gray, B., Semsarian, C., Sy, R. (2014). Brugada Syndrome: A Heterogeneous Disease with a Common ECG Phenotype? Journal of Cardiovascular Electrophysiology, 25(4), 450-456. [More Information]
  • Ingles, J., Semsarian, C. (2014). Conveying a probabilistic genetic test result to families with an inherited heart disease. Heart Rhythm, 11(6), 1073-1078. [More Information]
  • Puranik, R., Dennis, M., Semsarian, C., Bannon, P., Tanous, D., Celermajer, D. (2014). Detection of Serious Complications by MR Imaging in Asymptomatic Young Adults with Repaired Coarctation of the Aorta. Heart, Lung and Circulation, 23, 332-338. [More Information]
  • Das K, J., Ingles, J., Bagnall, R., Semsarian, C. (2014). Determining pathogenicity of genetic variants in hypertrophic cardiomyopathy: importance of periodic reassessment. Genetics in Medicine, 16(4), 286-293. [More Information]
  • Bagnall, R., Das K, J., Duflou, J., Semsarian, C. (2014). Exome analysis–based molecular autopsy in cases of sudden unexplained death in the young. Heart Rhythm, 11(4), 655-662. [More Information]
  • Femia, G., Hsu, C., Singarayar, S., Sy, R., Kilborn, M., Parker, G., McGuire, M., Semsarian, C., Puranik, R. (2014). Impact of new task force criteria in the diagnosis of arrhythmogenic right ventricular cardiomyopathy. International Journal of Cardiology, 171(2), 179-183. [More Information]
  • Spirito, P., Autore, C., Formisano, F., Gabriele, E., Biagini, E., Haas, T., Bongioanni, S., Semsarian, C., Devoto, E., Yeates, L., et al (2014). Risk of sudden death and outcome in patients with hypertrophic cardiomyopathy with benign presentation and without risk factors. The American Journal of Cardiology, 113(9), 1550-1555. [More Information]
  • Tsoutsman, T., Wang, X., Garchow, K., Riser, B., Twigg, S., Semsarian, C. (2013). CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. Journal of Molecular and Cellular Cardiology, 62, 164-178. [More Information]
  • Ingles, J., Sarina, T., Yeates, L., Hunt, L., Macciocca, I., McCormack, L., Winship, I., McGaughran, J., Atherton, J., Semsarian, C. (2013). Clinical predictors of genetic testing outcomes in hypertrophic cardiomyopathy. Genetics in Medicine, 15(12), 972-977. [More Information]
  • Semsarian, C., Ingles, J. (2013). Expanding the genetic spectrum of hypertrophic cardiomyopathy: x marks the spot. Circulation Cardiovascular Genetics, 6(6), 528-530. [More Information]
  • Costa, M., Guo, G., Wolstein, O., Vale, M., Castro, M., Wang, L., Otway, R., Riek, R., Cochrane, N., Furtado, M., Semsarian, C., et al (2013). Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy. Circulation Cardiovascular Genetics, 6(3), 238-247. [More Information]
  • Ingles, J., Yeates, L., Hunt, L., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2013). Health status of cardiac genetic disease patients and their at-risk relatives. International Journal of Cardiology, 165(3), 448-453. [More Information]
  • Gray, B., Yeates, L., Medi, C., Ingles, J., Semsarian, C. (2013). Homozygous mutation in the cardiac troponin I gene: Clinical heterogeneity in hypertrophic cardiomyopathy. International Journal of Cardiology, 168(2), 1530-1531. [More Information]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology: cellular and molecular biology of disease, 183(3), 745-757. [More Information]
  • Figtree, G., Bagnall, R., Abdulla, I., Buchholz, S., Karimi Galougahi, K., Yan, W., Tan, T., Neil, C., Horowitz, J., Semsarian, C., Ward, M. (2013). No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. European Journal of Heart Failure, 15(7), 730-733. [More Information]
  • Semsarian, C., Weintraub, R. (2013). Paediatric cardiomyopathy: Getting to the heart of the matter. The Lancet, 382(9908), 1866-1867. [More Information]
  • Yeates, L., Hunt, L., Saleh, M., Semsarian, C., Ingles, J. (2013). Poor psychological wellbeing particularly in mothers following sudden cardiac death in the young. European Journal of Cardiovascular Nursing, 12(5), 484-491. [More Information]
  • Sweeting, J., Duflou, J., Semsarian, C. (2013). Postmortem analysis of cardiovascular deaths in schizophrenia: A 10-year review. Schizophrenia Research, 150(2-3), 398-403. [More Information]
  • Evans, A., Bagnall, R., Duflou, J., Semsarian, C. (2013). Postmortem review and genetic analysis in sudden infant death syndrome: an 11-year review. Human Pathology, 44(9), 1730-1736. [More Information]
  • Maron, B., Spirito, P., Ackerman, M., Casey, S., Semsarian, C., Estes, N., Shannon, K., Ashley, E., Day, S., Pacileo, G., et al (2013). Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 61(14), 1527-1535. [More Information]
  • Gray, B., Ingles, J., Medi, C., Semsarian, C. (2013). Prolongation of the QTc Interval Predicts Appropriate Implantable Cardioverter-Defibrillator Therapies in Hypertrophic Cardiomyopathy. JACC: Heart Failure, 1(2), 149-155. [More Information]
  • Ingles, J., Sarina, T., Kasparian, N., Semsarian, C. (2013). Psychological wellbeing and posttraumatic stress associated with implantable cardioverter defibrillator therapy in young adults with genetic heart disease. International Journal of Cardiology, 168(4), 3779-3784. [More Information]
  • Ingles, J., Semsarian, C. (2013). The Australian Genetic Heart Disease Registry. International Journal of Cardiology, 168(4), e127-e128. [More Information]
  • Padang, R., Bannon, P., Jeremy, R., Richmond, D., Semsarian, C., Vallely, M., Wilson, M., Yan, T. (2013). The genetic and molecular basis of bicuspid aortic valve associated thoracic aortopathy: a link to phenotype heterogeneity. Annals of Cardiothoracic Surgery, 2(1), 83-91. [More Information]
  • Offen, S., Celermajer, D., Semsarian, C., Puranik, R. (2013). The role of diastolic filling in preserving left ventricular stroke volume - An MRI study. International Journal of Cardiology, 168(2), 1596-1598. [More Information]
  • Redfern, J., Ingles, J., Neubeck, A., Johnston, S., Semsarian, C. (2013). Tweeting Our Way to Cardiovascular Health. Journal of the American College of Cardiology, 61(15), 1657-1658. [More Information]
  • Alsheikh-Ali, A., Link, M., Semsarian, C., Shen, W., Mark Estes lll, N., Maron, M., Haas, T., Formisano, F., Boriani, G., Spirito, P., et al (2013). Ventricular tachycardia/fibrillation early after defibrillator implantation in patients with hypertrophic cardiomyopathy is explained by a high-risk subgroup of patients. Heart Rhythm, 10(2), 214-218. [More Information]
  • Ingles, J., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2012). A cost-effectiveness model of genetic testing for the evaluation of families with hypertrophic cardiomyopathy. Heart, 98(8), 625-630. [More Information]
  • Watts, G., Sullivan, D., van Bockxmeer, F., Poplawski, N., Hamilton-Craig, I., Clifton, P., O'Brien, R., Bishop, W., George, P., Semsarian, C., et al (2012). A New Model of Care for Familial Hypercholesterolaemia: What is the Role of Cardiology? Heart, Lung and Circulation, 21(9), 543-550. [More Information]
  • Gray, B., Das K, J., Semsarian, C. (2012). Consumption of energy drinks: A new provocation test for primary arrhythmogenic diseases? International Journal of Cardiology, 159(1), 77-78. [More Information]
  • Maron, B., Maron, M., Semsarian, C. (2012). Double or compound sarcomere mutations in hypertrophic cardiomyopathy: a potential link to sudden death in the absence of conventional risk factors. Heart Rhythm, 9(1), 57-63. [More Information]
  • Padang, R., Bagnall, R., Semsarian, C. (2012). Genetic Basis of Familial Valvular Heart Disease. Circulation: Cardiovascular Genetics, 5(5), 569-580. [More Information]
  • Ingles, J., Yeates, L., O'Brien, L., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2012). Genetic testing for inherited heart diseases: longitudinal impact on health-related quality of life. Genetics in Medicine, 14(8), 749-752. [More Information]
  • Maron, B., Maron, M., Semsarian, C. (2012). Genetics of hypertrophic cardiomyopathy after 20 years: clinical perspectives. Journal of the American College of Cardiology, 60(8), 705-715. [More Information]
  • Bagnall, R., Tsoutsman, T., Shephard, R., Ritchie, W., Semsarian, C. (2012). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PLoS One, 7(9), 1-8. [More Information]
  • Semsarian, C., Hamilton, R. (2012). Key role of the molecular autopsy in sudden unexpected death. Heart Rhythm, 9(1), 145-150. [More Information]
  • Maron, B., Semsarian, C. (2012). Prevention of sudden death for patients with cardiomyopathies another step forward. Journal of the American College of Cardiology, 59(5), 501-502. [More Information]
  • Padang, R., Bagnall, R., Richmond, D., Bannon, P., Semsarian, C. (2012). Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease. Journal of Molecular and Cellular Cardiology, 53(2), 277-281. [More Information]
  • Kelly, M., Bagnall, R., Peverill, R., Donelan, L., Corben, L., Delatycki, M., Semsarian, C. (2011). A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Journal of Molecular and Cellular Cardiology, 51(5), 848-854. [More Information]
  • Vohra, J., Skinner, J., Semsarian, C. (2011). Cardiac Genetic Investigation of Young Sudden Unexplained Death and Resuscitated Out of Hospital Cardiac Arrest. Heart, Lung and Circulation, 20(12), 746-750. [More Information]
  • Maron, B., Yeates, L., Semsarian, C. (2011). Clinical challenges of genotype positive (+)phenotype negative (-) family members in hypertrophic cardiomyopathy. The American Journal of Cardiology, 107(4), 604-608. [More Information]
  • Eshoo, S., Semsarian, C., Ross, D., Marwick, T., Thomas, L. (2011). Comparison of Left Atrial Phasic Function in Hypertrophic Cardiomyopathy Versus Systemic Hypertension Using Strain Rate Imaging. The American Journal of Cardiology, 107(2), 290-296. [More Information]
  • Tu, E., Waterhouse, L., Duflou, J., Bagnall, R., Semsarian, C. (2011). Genetic Analysis of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels in Sudden Unexpected in Epilepsy Cases. Brain Pathology, 21(6), 692-698. [More Information]
  • Maron, B., Ahluwalia, A., Haas, T., Semsarian, C., Link, M., Estes, N. (2011). Global epidemiology and demographics of commotio cordis. Heart Rhythm, 8(12), 1969-1971. [More Information]
  • Ingles, J., Zodgekar, P., Yeates, L., Macciocca, I., Semsarian, C., Fatkin, D., Members of CSANZ Cardiac Genetic Diseases Council Writing Group, M. (2011). Guidelines for genetic testing of inherited cardiac disorders. Heart, Lung and Circulation, 20(11), 681-687. [More Information]
  • Semsarian, C., Members of CSANZ Cardiac Genetic Diseases Council Writing Group, M. (2011). Guidelines for the diagnosis and management of hypertrophic cardiomyopathy. Heart, Lung and Circulation, 20(11), 688-690. [More Information]
  • Ackerman, M., Priori, S., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A., Ellinor, P., Gollob, M., et al, Semsarian, C. (2011). HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies. Europace, 13(8), 1077-1109. [More Information]
  • Gray, B., Semsarian, C., Sy, R., Jeremy, R. (2011). Left coronary artery fistula after septal myectomy in hypertrophic cardiomyopathy. Heart, Lung and Circulation, 20(11), 738-738. [More Information]
  • Bagnall, R., Ingles, J., Semsarian, C. (2011). Molecular diagnostics of cardiomyopathies: the future is here. Circulation Cardiovascular Genetics, 4(2), 103-104. [More Information]
  • Gray, B., Ingles, J., Semsarian, C. (2011). Natural history of genotype positive-phenotype negative patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 152(2), 258-259. [More Information]
  • Ng, D., Ng, I., Yeap, Y., Badrain, B., Tsoutsman, T., McMullen, J., Semsarian, C., Bogoyevitch, M. (2011). Opposing Actions of Extracellular Signal-Regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy. Journal of Biological Chemistry, 286(2), 1576-1587. [More Information]
  • Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D., et al (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9. [More Information]
  • Ingles, J., Yeates, L., Semsarian, C. (2011). The emerging role of the cardiac genetic counselor. Heart Rhythm, 8(12), 1958-1962. [More Information]
  • Qian, L., Wythe, J., Liu, J., Cartry, J., Vogler, G., Mohapatra, B., Otway, R., Huang, Y., King, I., Maillet, M., Semsarian, C., Winlaw, D., et al (2011). Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology, 193(7), 1181-1196. [More Information]
  • Bagnall, R., Yeates, L., Semsarian, C. (2010). Analysis of the Z-disc genes PDLIM3 and MYPN in Patients with Hypertrophic Cardiomyopathy. International Journal of Cardiology, 145(3), 601-2. [More Information]
  • Girolami, F., Ho, C., Semsarian, C., Baldi, M., Will, M., Baldini, K., Torricelli, F., Yeates, L., Cecchi, F., Ackerman, M., et al (2010). Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. Journal of the American College of Cardiology, 55(14). [More Information]
  • Lam, L., Tsoutsman, T., Arthur, J., Semsarian, C. (2010). Differential protein expression profiling of myocardial tissue in a mouse model of hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 48(5), 1014-1022. [More Information]
  • Maron, B., Semsarian, C. (2010). Emergence of gene mutation carriers and the expanding disease spectrum of hypertrophic cardiomyopathy. European heart journal, 31(13), 1551-1553. [More Information]
  • Eshoo, S., Semsarian, C., Ross, D., Thomas, L. (2010). Left Atrial Phasic Volumes Are Modulated by the Type Rather Than the Extent of Left Ventricular Hypertrophy. Journal of the American Society of Echocardiography, 23(5), 538-544. [More Information]
  • Chiu, C., Bagnall, R., Ingles, J., Yeates, L., Kennerson, M., Donald, J., Jormakka, M., Lind, J., Semsarian, C. (2010). Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy: A Genome-Wide Analysis. Journal of the American College of Cardiology, 55(11), 1127-1135. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Lynch, M., Twigg, S., Semsarian, C. (2010). Post-mortem pathologic and genetic studies in "dead in bed syndrome" cases in type 1 diabetes mellitus. Human Pathology, 41(3), 392-400. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Semsarian, C. (2010). Post-Mortem Review and Genetic Analysis of Sudden Unexpected Death in Epilepsy (SUDEP) Cases. Brain Pathology, , 1-8. [More Information]
  • Tu, E., Twigg, S., Semsarian, C. (2010). Sudden death in type 1 diabetes: The mystery of the 'dead in bed' syndrome. International Journal of Cardiology, 138(1), 91-93. [More Information]
  • Shepard, R., Semsarian, C. (2009). Advances in the prevention of sudden cardiac death in the young. Therapeutic Advances in Cardiovascular Disease, 3(2), 145-155. [More Information]
  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009). Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American Journal of Physiology: Cell Physiology, 297(6), c1490-c1500. [More Information]
  • Maron, B., Semsarian, C., Shen, W., Link, M., Epstein, A., Estes, N., Almquist, A., Giudici, M., Haas, T., Hodges, J., et al (2009). Circadian patterns in the occurrence of malignant ventricular tachyarrhythmias triggering defibrillator interventions in patients with hypertrophic cardiomyopathy. Heart Rhythm, 6(5), 599-602. [More Information]
  • Kelly, M., Semsarian, C. (2009). Multiple mutations in genetic cardiovascular disease: a marker of disease severity? Circulation: Cardiovascular Genetics, 2(2), 182-190. [More Information]
  • Wilcox, I., Semsarian, C. (2009). Obstructive sleep apnea a respiratory syndrome with protean cardiovascular manifestations. Journal of the American College of Cardiology, 54(19), 1810-1812. [More Information]
  • Sherrid, M., Cotiga, D., Hart, D., Ehlert, F., Haas, T., Shen, W., Link, M., Estes, N., Epstein, A., et al, Semsarian, C. (2009). Relation of 12-lead electrocardiogram patterns to implanted defibrillator-terminated ventricular tachyarrhythmias in hypertrophic cardiomyopathy. The American Journal of Cardiology, 104(12), 1722-1726. [More Information]
  • Shephard, R., Semsarian, C. (2009). Role of animal models in HCM research. Journal of Cardiovascular Translational Research, 2(4), 471-482. [More Information]
  • Bagnall, R., Yeates, L., Semsarian, C. (2009). The role of large gene deletions and duplications in MYBPC3 and TNNT2 in patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 145, 150-3. [More Information]
  • Semsarian, C. (2009). Use of mouse models for the analysis of human disease. Current Protocols in Human Genetics, , 15.2.1-15.2.10. [More Information]
  • Tu, E., Twigg, S., Duflou, J., Semsarian, C. (2008). Causes of death in young Australians with type 1 diabetes: a review of coronial postmortem examinations. Medical Journal of Australia, 188(12), 699-702. [More Information]
  • Ingles, J., McGaughran, J., Vohra, J., Weintraub, R., Davis, A., Atherton, J., Semsarian, C. (2008). Establishment of an Australian National Genetic Heart Disease Registry. Heart, Lung and Circulation, 17(6), 463-467. [More Information]
  • Tsoutsman, T., Bagnall, R., Semsarian, C. (2008). Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure. Clinical and Experimental Pharmacology and Physiology, 35(11), 1349-1357. [More Information]
  • Vallely, M., Semsarian, C., Bannon, P. (2008). Management of the Ascending Aorta in Patients with Bicuspid Aortic Valve Disease. Heart, Lung and Circulation, 17(5), 357-363. [More Information]
  • Doolan, A., Langlois, N., Chiu, C., Ingles, J., Lind, J., Semsarian, C. (2008). Postmortem molecular analysis of KCNQ1 and SCN5A genes in sudden unexplained death in young Australians. International Journal of Cardiology, 127, 138-141. [More Information]
  • Ingles, J., Lind, J., Phongsavan, P., Semsarian, C. (2008). Psychosocial impact of specialized cardiac genetic clinics for hypertrophic cardiomyopathy. Genetics in Medicine, 10(2), 117-120. [More Information]
  • Skinner, J., Duflou, J., Semsarian, C. (2008). Reducing sudden death in young people in Australia and New Zealand: The TRAGADY initiative. Medical Journal of Australia, 189(10), 539-540. [More Information]
  • Tsoutsman, T., Kelly, M., Ng, D., Tan, J., Tu, E., Lien, L., Bogoyevitch, M., Seidman, C., Seidman, J., Semsarian, C. (2008). Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation, 117(14), 1820-1831. [More Information]
  • Lind, J., Chiu, C., Ingles, J., Yeates, L., Humphries, S., Heather, A., Semsarian, C. (2008). Sex hormone receptor gene variation associated with phenotype in male hypertrophic cardiomyopathy patients. Journal of Molecular and Cellular Cardiology, 45(2), 217-222. [More Information]
  • Chiu, C., Tebo, M., Ingles, J., Yeates, L., Arthur, J., Lind, J., Semsarian, C. (2007). Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 43, 337-343. [More Information]
  • Semsarian, C. (2007). Guidelines for the Diagnosis and Management of Hypertrophic Cardiomyopathy. Heart, Lung and Circulation, 16(1), 16-18. [More Information]
  • Maron, B., Spirito, P., Shen, W., Haas, T., Formisano, F., Link, M., Epstein, A., Almquist, A., Daubert, J., Lawrenz, T., Semsarian, C., et al (2007). Implantable Cardioverter-Defibrillators and Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathy. JAMA: The Journal of the American Medical Association, 298(4), 405-412. [More Information]
  • Lam, L., Arthur, J., Semsarian, C. (2007). Proteome map of the normal murine ventricular myocardium. Proteomics, 7(19), 3629-3633. [More Information]
  • Ingles, J., Semsarian, C. (2007). Sudden cardiac death in the young: a clinical genetic approach. Internal Medicine Journal, 37(1), 32-37. [More Information]
  • Nguyen, L., Chung, J., Lam, L., Tsoutsman, T., Semsarian, C. (2006). Abnormal cardiac response to exercise in a murine model of familial hypertrophic cardiomyopathy. International Journal of Cardiology, , 1-4. [More Information]
  • Lam, L., Lind, J., Semsarian, C. (2006). Application of proteomics in cardiovascular medicine. International Journal of Cardiology, 108(1), 12-19. [More Information]
  • Tsoutsman, T., Lam, L., Semsarian, C. (2006). Genes, calcium and modifying factors in hypertrophic cardiomyopathy. Clinical and Experimental Pharmacology and Physiology, 33, 139-145. [More Information]
  • Lind, J., Chiu, C., Semsarian, C. (2006). Genetic basis of hypertrophic cardiomyopathy. Expert Review of Cardiovascular Therapy, 4(6), 927-934. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Bailey, C., Rasko, J., Allen, D., Semsarian, C. (2006). Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 41(4), 623-632. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Rasko, J., Bailey, C., Allen, D., Semsarian, C. (2006). Mouse cardiac troponin I model of hypertrophic cardiomyopathy: Phenotype associated with abnormal calcium handling. Journal of Molecular and Cellular Cardiology, 41(4), 747 (abstract 41)-747.
  • Chiu, C., Ingles, J., Lind, J., Semsarian, C. (2006). Mutation analysis of the natriuretic peptide precursor B (NPPB) gene in patients with hypertrophic cardiomyopathy. DNA Sequence, 17(5), 392-395. [More Information]
  • Lind, J., Semsarian, C. (2006). Overview of model systems for the analysis of human disease. Current Protocols in Human Genetics, , Unit 15.1. [More Information]
  • Herron, B., Rao, C., Liu, S., Laprade, L., Richardson, J., Oliveri, E., Semsarian, C., Millar, S., Stubbs, L., Beier, D. (2005). A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Human Molecular Genetics, 14(5), 667-677. [More Information]
  • Doolan, A., Tebo, M., Ingles, J., Nguyen, L., Tsoutsman, T., Lam, L., Chiu, C., Chung, J., Weintraub, R., Semsarian, C. (2005). Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. Journal of Molecular and Cellular Cardiology, 38(2), 387-93. [More Information]
  • Ingles, J., Doolan, A., Chiu, C., Seidman, J., Seidman, C., Semsarian, C. (2005). Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. Journal of Medical Genetics, 42(10), 1-6. [More Information]
  • Megevand, A., Ingles, J., Richmond, D., Semsarian, C. (2005). Long-term follow-up of patients with obstructive hypertrophic cardiomyopathy treated with dual-chamber pacing. The American Journal of Cardiology, 95(8), 991-993. [More Information]
  • Wolf, C., Moskowitz, I., Arno, S., Branco, D., Semsarian, C., Bernstein, S., Peterson, M., Maida, M., Morley, G., Fishman, G., et al (2005). Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 102(50), 18123-18128. [More Information]
  • Doolan, A., Langlois, N., Semsarian, C. (2004). Causes Of Sudden Cardiac Death In Young Australians. Medical Journal of Australia, 180(3), 110-112.
  • Doolan, A., Nguyen, L., Semsarian, C. (2004). Hypertrophic Cardiomyopathy: From "Heart Tumour" To A Complex Molecular Genetic Disorder. Heart, Lung and Circulation, 13(1), 15-25.
  • Jayatilleke, I., Doolan, A., Ingles, J., McGuire, M., Booth, V., Richmond, D., Semsarian, C. (2004). Long-Term Follow-Up Of Implantable Cardioverter Defibrillator Therapy For Hypertrophic Cardiomyopathy. The American Journal of Cardiology, 93(9), 1192-1194. [More Information]
  • Doolan, G., Nguyen, L., Chung, J., Ingles, J., Semsarian, C. (2004). Progression Of Left Ventricular Hypertrophy And The Angiotensin-Converting Enzyme Gene Polymorphism In Hypertrophic Cardiomyopathy. International Journal of Cardiology, 96(2), 157-163.
  • Schmitt, J., Semsarian, C., Arad, M., Gannon, J., Ahmad, F., Duffy, C., Lee, R., Seidman, C., Seidman, J. (2003). Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomypathy. Circulation, 108(9), 1133-1138.
  • Chung, M., Tsoutsman, T., Semsarian, C. (2003). Hypertrophic cardiomyopathy: from gene defect to clinical disease. Cell Research, 13(1), 9-20.
  • Jayatilleke, I., McGuire, M., Booth, V., Richmond, D., Semsarian, C. (2003). Sudden death prevented in hypertrophic cardiomyopathy. Heart, Lung and Circulation, 12(3), 196-198.
  • Semsarian, C. (2002). Stem cells in cardiovascular disease: from cell biology to clinical therapy. Internal Medicine Journal, 32(5-6), 259-265.

Conferences

  • Neubeck, A., Lowres, N., Semsarian, C., Ingles, J., Johnston, S., Redfern, J. (2012). Social Media and Cardiac Rehabilitation: A Systematic Review. 22nd Australian Cardiovascular Health and Rehabilitation Association (ACRA) Annual Conference 2012, Brisbane, Queensland, Australia.
  • Ingles, J., Doolan, A., Chiu, C., Seidman, J., Seidman, C., Semsarian, C. (2005). Compound and double mutations in hypertrophic cardiomyopathy patients: Implications for genetic testing and counselling. American Heart Association Annual Scientific Sessions 2005, United States: American Heart Association.

2014

  • Gray, B., Semsarian, C., Sy, R. (2014). Brugada Syndrome: A Heterogeneous Disease with a Common ECG Phenotype? Journal of Cardiovascular Electrophysiology, 25(4), 450-456. [More Information]
  • Ingles, J., Semsarian, C. (2014). Conveying a probabilistic genetic test result to families with an inherited heart disease. Heart Rhythm, 11(6), 1073-1078. [More Information]
  • Puranik, R., Dennis, M., Semsarian, C., Bannon, P., Tanous, D., Celermajer, D. (2014). Detection of Serious Complications by MR Imaging in Asymptomatic Young Adults with Repaired Coarctation of the Aorta. Heart, Lung and Circulation, 23, 332-338. [More Information]
  • Das K, J., Ingles, J., Bagnall, R., Semsarian, C. (2014). Determining pathogenicity of genetic variants in hypertrophic cardiomyopathy: importance of periodic reassessment. Genetics in Medicine, 16(4), 286-293. [More Information]
  • Bagnall, R., Das K, J., Duflou, J., Semsarian, C. (2014). Exome analysis–based molecular autopsy in cases of sudden unexplained death in the young. Heart Rhythm, 11(4), 655-662. [More Information]
  • Femia, G., Hsu, C., Singarayar, S., Sy, R., Kilborn, M., Parker, G., McGuire, M., Semsarian, C., Puranik, R. (2014). Impact of new task force criteria in the diagnosis of arrhythmogenic right ventricular cardiomyopathy. International Journal of Cardiology, 171(2), 179-183. [More Information]
  • Spirito, P., Autore, C., Formisano, F., Gabriele, E., Biagini, E., Haas, T., Bongioanni, S., Semsarian, C., Devoto, E., Yeates, L., et al (2014). Risk of sudden death and outcome in patients with hypertrophic cardiomyopathy with benign presentation and without risk factors. The American Journal of Cardiology, 113(9), 1550-1555. [More Information]

2013

  • Tsoutsman, T., Wang, X., Garchow, K., Riser, B., Twigg, S., Semsarian, C. (2013). CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. Journal of Molecular and Cellular Cardiology, 62, 164-178. [More Information]
  • Ingles, J., Sarina, T., Yeates, L., Hunt, L., Macciocca, I., McCormack, L., Winship, I., McGaughran, J., Atherton, J., Semsarian, C. (2013). Clinical predictors of genetic testing outcomes in hypertrophic cardiomyopathy. Genetics in Medicine, 15(12), 972-977. [More Information]
  • Semsarian, C., Ingles, J. (2013). Expanding the genetic spectrum of hypertrophic cardiomyopathy: x marks the spot. Circulation Cardiovascular Genetics, 6(6), 528-530. [More Information]
  • Costa, M., Guo, G., Wolstein, O., Vale, M., Castro, M., Wang, L., Otway, R., Riek, R., Cochrane, N., Furtado, M., Semsarian, C., et al (2013). Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy. Circulation Cardiovascular Genetics, 6(3), 238-247. [More Information]
  • Ingles, J., Yeates, L., Hunt, L., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2013). Health status of cardiac genetic disease patients and their at-risk relatives. International Journal of Cardiology, 165(3), 448-453. [More Information]
  • Gray, B., Yeates, L., Medi, C., Ingles, J., Semsarian, C. (2013). Homozygous mutation in the cardiac troponin I gene: Clinical heterogeneity in hypertrophic cardiomyopathy. International Journal of Cardiology, 168(2), 1530-1531. [More Information]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology: cellular and molecular biology of disease, 183(3), 745-757. [More Information]
  • Figtree, G., Bagnall, R., Abdulla, I., Buchholz, S., Karimi Galougahi, K., Yan, W., Tan, T., Neil, C., Horowitz, J., Semsarian, C., Ward, M. (2013). No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. European Journal of Heart Failure, 15(7), 730-733. [More Information]
  • Semsarian, C., Weintraub, R. (2013). Paediatric cardiomyopathy: Getting to the heart of the matter. The Lancet, 382(9908), 1866-1867. [More Information]
  • Yeates, L., Hunt, L., Saleh, M., Semsarian, C., Ingles, J. (2013). Poor psychological wellbeing particularly in mothers following sudden cardiac death in the young. European Journal of Cardiovascular Nursing, 12(5), 484-491. [More Information]
  • Sweeting, J., Duflou, J., Semsarian, C. (2013). Postmortem analysis of cardiovascular deaths in schizophrenia: A 10-year review. Schizophrenia Research, 150(2-3), 398-403. [More Information]
  • Evans, A., Bagnall, R., Duflou, J., Semsarian, C. (2013). Postmortem review and genetic analysis in sudden infant death syndrome: an 11-year review. Human Pathology, 44(9), 1730-1736. [More Information]
  • Maron, B., Spirito, P., Ackerman, M., Casey, S., Semsarian, C., Estes, N., Shannon, K., Ashley, E., Day, S., Pacileo, G., et al (2013). Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 61(14), 1527-1535. [More Information]
  • Gray, B., Ingles, J., Medi, C., Semsarian, C. (2013). Prolongation of the QTc Interval Predicts Appropriate Implantable Cardioverter-Defibrillator Therapies in Hypertrophic Cardiomyopathy. JACC: Heart Failure, 1(2), 149-155. [More Information]
  • Ingles, J., Sarina, T., Kasparian, N., Semsarian, C. (2013). Psychological wellbeing and posttraumatic stress associated with implantable cardioverter defibrillator therapy in young adults with genetic heart disease. International Journal of Cardiology, 168(4), 3779-3784. [More Information]
  • Ingles, J., Semsarian, C. (2013). The Australian Genetic Heart Disease Registry. International Journal of Cardiology, 168(4), e127-e128. [More Information]
  • Padang, R., Bannon, P., Jeremy, R., Richmond, D., Semsarian, C., Vallely, M., Wilson, M., Yan, T. (2013). The genetic and molecular basis of bicuspid aortic valve associated thoracic aortopathy: a link to phenotype heterogeneity. Annals of Cardiothoracic Surgery, 2(1), 83-91. [More Information]
  • Offen, S., Celermajer, D., Semsarian, C., Puranik, R. (2013). The role of diastolic filling in preserving left ventricular stroke volume - An MRI study. International Journal of Cardiology, 168(2), 1596-1598. [More Information]
  • Redfern, J., Ingles, J., Neubeck, A., Johnston, S., Semsarian, C. (2013). Tweeting Our Way to Cardiovascular Health. Journal of the American College of Cardiology, 61(15), 1657-1658. [More Information]
  • Alsheikh-Ali, A., Link, M., Semsarian, C., Shen, W., Mark Estes lll, N., Maron, M., Haas, T., Formisano, F., Boriani, G., Spirito, P., et al (2013). Ventricular tachycardia/fibrillation early after defibrillator implantation in patients with hypertrophic cardiomyopathy is explained by a high-risk subgroup of patients. Heart Rhythm, 10(2), 214-218. [More Information]

2012

  • Ingles, J., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2012). A cost-effectiveness model of genetic testing for the evaluation of families with hypertrophic cardiomyopathy. Heart, 98(8), 625-630. [More Information]
  • Watts, G., Sullivan, D., van Bockxmeer, F., Poplawski, N., Hamilton-Craig, I., Clifton, P., O'Brien, R., Bishop, W., George, P., Semsarian, C., et al (2012). A New Model of Care for Familial Hypercholesterolaemia: What is the Role of Cardiology? Heart, Lung and Circulation, 21(9), 543-550. [More Information]
  • Gray, B., Das K, J., Semsarian, C. (2012). Consumption of energy drinks: A new provocation test for primary arrhythmogenic diseases? International Journal of Cardiology, 159(1), 77-78. [More Information]
  • Maron, B., Maron, M., Semsarian, C. (2012). Double or compound sarcomere mutations in hypertrophic cardiomyopathy: a potential link to sudden death in the absence of conventional risk factors. Heart Rhythm, 9(1), 57-63. [More Information]
  • Padang, R., Bagnall, R., Semsarian, C. (2012). Genetic Basis of Familial Valvular Heart Disease. Circulation: Cardiovascular Genetics, 5(5), 569-580. [More Information]
  • Ingles, J., Yeates, L., O'Brien, L., McGaughran, J., Scuffham, P., Atherton, J., Semsarian, C. (2012). Genetic testing for inherited heart diseases: longitudinal impact on health-related quality of life. Genetics in Medicine, 14(8), 749-752. [More Information]
  • Maron, B., Maron, M., Semsarian, C. (2012). Genetics of hypertrophic cardiomyopathy after 20 years: clinical perspectives. Journal of the American College of Cardiology, 60(8), 705-715. [More Information]
  • Bagnall, R., Tsoutsman, T., Shephard, R., Ritchie, W., Semsarian, C. (2012). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PLoS One, 7(9), 1-8. [More Information]
  • Semsarian, C., Hamilton, R. (2012). Key role of the molecular autopsy in sudden unexpected death. Heart Rhythm, 9(1), 145-150. [More Information]
  • Maron, B., Semsarian, C. (2012). Prevention of sudden death for patients with cardiomyopathies another step forward. Journal of the American College of Cardiology, 59(5), 501-502. [More Information]
  • Padang, R., Bagnall, R., Richmond, D., Bannon, P., Semsarian, C. (2012). Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease. Journal of Molecular and Cellular Cardiology, 53(2), 277-281. [More Information]
  • Neubeck, A., Lowres, N., Semsarian, C., Ingles, J., Johnston, S., Redfern, J. (2012). Social Media and Cardiac Rehabilitation: A Systematic Review. 22nd Australian Cardiovascular Health and Rehabilitation Association (ACRA) Annual Conference 2012, Brisbane, Queensland, Australia.

2011

  • Kelly, M., Bagnall, R., Peverill, R., Donelan, L., Corben, L., Delatycki, M., Semsarian, C. (2011). A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Journal of Molecular and Cellular Cardiology, 51(5), 848-854. [More Information]
  • Vohra, J., Skinner, J., Semsarian, C. (2011). Cardiac Genetic Investigation of Young Sudden Unexplained Death and Resuscitated Out of Hospital Cardiac Arrest. Heart, Lung and Circulation, 20(12), 746-750. [More Information]
  • Maron, B., Yeates, L., Semsarian, C. (2011). Clinical challenges of genotype positive (+)phenotype negative (-) family members in hypertrophic cardiomyopathy. The American Journal of Cardiology, 107(4), 604-608. [More Information]
  • Eshoo, S., Semsarian, C., Ross, D., Marwick, T., Thomas, L. (2011). Comparison of Left Atrial Phasic Function in Hypertrophic Cardiomyopathy Versus Systemic Hypertension Using Strain Rate Imaging. The American Journal of Cardiology, 107(2), 290-296. [More Information]
  • Tu, E., Waterhouse, L., Duflou, J., Bagnall, R., Semsarian, C. (2011). Genetic Analysis of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels in Sudden Unexpected in Epilepsy Cases. Brain Pathology, 21(6), 692-698. [More Information]
  • Maron, B., Ahluwalia, A., Haas, T., Semsarian, C., Link, M., Estes, N. (2011). Global epidemiology and demographics of commotio cordis. Heart Rhythm, 8(12), 1969-1971. [More Information]
  • Ingles, J., Zodgekar, P., Yeates, L., Macciocca, I., Semsarian, C., Fatkin, D., Members of CSANZ Cardiac Genetic Diseases Council Writing Group, M. (2011). Guidelines for genetic testing of inherited cardiac disorders. Heart, Lung and Circulation, 20(11), 681-687. [More Information]
  • Semsarian, C., Members of CSANZ Cardiac Genetic Diseases Council Writing Group, M. (2011). Guidelines for the diagnosis and management of hypertrophic cardiomyopathy. Heart, Lung and Circulation, 20(11), 688-690. [More Information]
  • Ackerman, M., Priori, S., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A., Ellinor, P., Gollob, M., et al, Semsarian, C. (2011). HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies. Europace, 13(8), 1077-1109. [More Information]
  • Gray, B., Semsarian, C., Sy, R., Jeremy, R. (2011). Left coronary artery fistula after septal myectomy in hypertrophic cardiomyopathy. Heart, Lung and Circulation, 20(11), 738-738. [More Information]
  • Bagnall, R., Ingles, J., Semsarian, C. (2011). Molecular diagnostics of cardiomyopathies: the future is here. Circulation Cardiovascular Genetics, 4(2), 103-104. [More Information]
  • Gray, B., Ingles, J., Semsarian, C. (2011). Natural history of genotype positive-phenotype negative patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 152(2), 258-259. [More Information]
  • Ng, D., Ng, I., Yeap, Y., Badrain, B., Tsoutsman, T., McMullen, J., Semsarian, C., Bogoyevitch, M. (2011). Opposing Actions of Extracellular Signal-Regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy. Journal of Biological Chemistry, 286(2), 1576-1587. [More Information]
  • Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D., et al (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9. [More Information]
  • Ingles, J., Yeates, L., Semsarian, C. (2011). The emerging role of the cardiac genetic counselor. Heart Rhythm, 8(12), 1958-1962. [More Information]
  • Qian, L., Wythe, J., Liu, J., Cartry, J., Vogler, G., Mohapatra, B., Otway, R., Huang, Y., King, I., Maillet, M., Semsarian, C., Winlaw, D., et al (2011). Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology, 193(7), 1181-1196. [More Information]

2010

  • Bagnall, R., Yeates, L., Semsarian, C. (2010). Analysis of the Z-disc genes PDLIM3 and MYPN in Patients with Hypertrophic Cardiomyopathy. International Journal of Cardiology, 145(3), 601-2. [More Information]
  • Girolami, F., Ho, C., Semsarian, C., Baldi, M., Will, M., Baldini, K., Torricelli, F., Yeates, L., Cecchi, F., Ackerman, M., et al (2010). Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. Journal of the American College of Cardiology, 55(14). [More Information]
  • Lam, L., Tsoutsman, T., Arthur, J., Semsarian, C. (2010). Differential protein expression profiling of myocardial tissue in a mouse model of hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 48(5), 1014-1022. [More Information]
  • Maron, B., Semsarian, C. (2010). Emergence of gene mutation carriers and the expanding disease spectrum of hypertrophic cardiomyopathy. European heart journal, 31(13), 1551-1553. [More Information]
  • Eshoo, S., Semsarian, C., Ross, D., Thomas, L. (2010). Left Atrial Phasic Volumes Are Modulated by the Type Rather Than the Extent of Left Ventricular Hypertrophy. Journal of the American Society of Echocardiography, 23(5), 538-544. [More Information]
  • Chiu, C., Bagnall, R., Ingles, J., Yeates, L., Kennerson, M., Donald, J., Jormakka, M., Lind, J., Semsarian, C. (2010). Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy: A Genome-Wide Analysis. Journal of the American College of Cardiology, 55(11), 1127-1135. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Lynch, M., Twigg, S., Semsarian, C. (2010). Post-mortem pathologic and genetic studies in "dead in bed syndrome" cases in type 1 diabetes mellitus. Human Pathology, 41(3), 392-400. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Semsarian, C. (2010). Post-Mortem Review and Genetic Analysis of Sudden Unexpected Death in Epilepsy (SUDEP) Cases. Brain Pathology, , 1-8. [More Information]
  • Tu, E., Twigg, S., Semsarian, C. (2010). Sudden death in type 1 diabetes: The mystery of the 'dead in bed' syndrome. International Journal of Cardiology, 138(1), 91-93. [More Information]

2009

  • Shepard, R., Semsarian, C. (2009). Advances in the prevention of sudden cardiac death in the young. Therapeutic Advances in Cardiovascular Disease, 3(2), 145-155. [More Information]
  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009). Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American Journal of Physiology: Cell Physiology, 297(6), c1490-c1500. [More Information]
  • Maron, B., Semsarian, C., Shen, W., Link, M., Epstein, A., Estes, N., Almquist, A., Giudici, M., Haas, T., Hodges, J., et al (2009). Circadian patterns in the occurrence of malignant ventricular tachyarrhythmias triggering defibrillator interventions in patients with hypertrophic cardiomyopathy. Heart Rhythm, 6(5), 599-602. [More Information]
  • Kelly, M., Semsarian, C. (2009). Multiple mutations in genetic cardiovascular disease: a marker of disease severity? Circulation: Cardiovascular Genetics, 2(2), 182-190. [More Information]
  • Wilcox, I., Semsarian, C. (2009). Obstructive sleep apnea a respiratory syndrome with protean cardiovascular manifestations. Journal of the American College of Cardiology, 54(19), 1810-1812. [More Information]
  • Sherrid, M., Cotiga, D., Hart, D., Ehlert, F., Haas, T., Shen, W., Link, M., Estes, N., Epstein, A., et al, Semsarian, C. (2009). Relation of 12-lead electrocardiogram patterns to implanted defibrillator-terminated ventricular tachyarrhythmias in hypertrophic cardiomyopathy. The American Journal of Cardiology, 104(12), 1722-1726. [More Information]
  • Shephard, R., Semsarian, C. (2009). Role of animal models in HCM research. Journal of Cardiovascular Translational Research, 2(4), 471-482. [More Information]
  • Bagnall, R., Yeates, L., Semsarian, C. (2009). The role of large gene deletions and duplications in MYBPC3 and TNNT2 in patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 145, 150-3. [More Information]
  • Semsarian, C. (2009). Use of mouse models for the analysis of human disease. Current Protocols in Human Genetics, , 15.2.1-15.2.10. [More Information]

2008

  • Tu, E., Twigg, S., Duflou, J., Semsarian, C. (2008). Causes of death in young Australians with type 1 diabetes: a review of coronial postmortem examinations. Medical Journal of Australia, 188(12), 699-702. [More Information]
  • Ingles, J., McGaughran, J., Vohra, J., Weintraub, R., Davis, A., Atherton, J., Semsarian, C. (2008). Establishment of an Australian National Genetic Heart Disease Registry. Heart, Lung and Circulation, 17(6), 463-467. [More Information]
  • Tsoutsman, T., Bagnall, R., Semsarian, C. (2008). Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure. Clinical and Experimental Pharmacology and Physiology, 35(11), 1349-1357. [More Information]
  • Vallely, M., Semsarian, C., Bannon, P. (2008). Management of the Ascending Aorta in Patients with Bicuspid Aortic Valve Disease. Heart, Lung and Circulation, 17(5), 357-363. [More Information]
  • Doolan, A., Langlois, N., Chiu, C., Ingles, J., Lind, J., Semsarian, C. (2008). Postmortem molecular analysis of KCNQ1 and SCN5A genes in sudden unexplained death in young Australians. International Journal of Cardiology, 127, 138-141. [More Information]
  • Ingles, J., Lind, J., Phongsavan, P., Semsarian, C. (2008). Psychosocial impact of specialized cardiac genetic clinics for hypertrophic cardiomyopathy. Genetics in Medicine, 10(2), 117-120. [More Information]
  • Skinner, J., Duflou, J., Semsarian, C. (2008). Reducing sudden death in young people in Australia and New Zealand: The TRAGADY initiative. Medical Journal of Australia, 189(10), 539-540. [More Information]
  • Tsoutsman, T., Kelly, M., Ng, D., Tan, J., Tu, E., Lien, L., Bogoyevitch, M., Seidman, C., Seidman, J., Semsarian, C. (2008). Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation, 117(14), 1820-1831. [More Information]
  • Lind, J., Chiu, C., Ingles, J., Yeates, L., Humphries, S., Heather, A., Semsarian, C. (2008). Sex hormone receptor gene variation associated with phenotype in male hypertrophic cardiomyopathy patients. Journal of Molecular and Cellular Cardiology, 45(2), 217-222. [More Information]

2007

  • Chiu, C., Tebo, M., Ingles, J., Yeates, L., Arthur, J., Lind, J., Semsarian, C. (2007). Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 43, 337-343. [More Information]
  • Semsarian, C. (2007). Guidelines for the Diagnosis and Management of Hypertrophic Cardiomyopathy. Heart, Lung and Circulation, 16(1), 16-18. [More Information]
  • Maron, B., Spirito, P., Shen, W., Haas, T., Formisano, F., Link, M., Epstein, A., Almquist, A., Daubert, J., Lawrenz, T., Semsarian, C., et al (2007). Implantable Cardioverter-Defibrillators and Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathy. JAMA: The Journal of the American Medical Association, 298(4), 405-412. [More Information]
  • Lam, L., Arthur, J., Semsarian, C. (2007). Proteome map of the normal murine ventricular myocardium. Proteomics, 7(19), 3629-3633. [More Information]
  • Ingles, J., Semsarian, C. (2007). Sudden cardiac death in the young: a clinical genetic approach. Internal Medicine Journal, 37(1), 32-37. [More Information]

2006

  • Nguyen, L., Chung, J., Lam, L., Tsoutsman, T., Semsarian, C. (2006). Abnormal cardiac response to exercise in a murine model of familial hypertrophic cardiomyopathy. International Journal of Cardiology, , 1-4. [More Information]
  • Lam, L., Lind, J., Semsarian, C. (2006). Application of proteomics in cardiovascular medicine. International Journal of Cardiology, 108(1), 12-19. [More Information]
  • Tsoutsman, T., Lam, L., Semsarian, C. (2006). Genes, calcium and modifying factors in hypertrophic cardiomyopathy. Clinical and Experimental Pharmacology and Physiology, 33, 139-145. [More Information]
  • Lind, J., Chiu, C., Semsarian, C. (2006). Genetic basis of hypertrophic cardiomyopathy. Expert Review of Cardiovascular Therapy, 4(6), 927-934. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Bailey, C., Rasko, J., Allen, D., Semsarian, C. (2006). Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 41(4), 623-632. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Rasko, J., Bailey, C., Allen, D., Semsarian, C. (2006). Mouse cardiac troponin I model of hypertrophic cardiomyopathy: Phenotype associated with abnormal calcium handling. Journal of Molecular and Cellular Cardiology, 41(4), 747 (abstract 41)-747.
  • Chiu, C., Ingles, J., Lind, J., Semsarian, C. (2006). Mutation analysis of the natriuretic peptide precursor B (NPPB) gene in patients with hypertrophic cardiomyopathy. DNA Sequence, 17(5), 392-395. [More Information]
  • Lind, J., Semsarian, C. (2006). Overview of model systems for the analysis of human disease. Current Protocols in Human Genetics, , Unit 15.1. [More Information]

2005

  • Herron, B., Rao, C., Liu, S., Laprade, L., Richardson, J., Oliveri, E., Semsarian, C., Millar, S., Stubbs, L., Beier, D. (2005). A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Human Molecular Genetics, 14(5), 667-677. [More Information]
  • Doolan, A., Tebo, M., Ingles, J., Nguyen, L., Tsoutsman, T., Lam, L., Chiu, C., Chung, J., Weintraub, R., Semsarian, C. (2005). Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. Journal of Molecular and Cellular Cardiology, 38(2), 387-93. [More Information]
  • Ingles, J., Doolan, A., Chiu, C., Seidman, J., Seidman, C., Semsarian, C. (2005). Compound and double mutations in hypertrophic cardiomyopathy patients: Implications for genetic testing and counselling. American Heart Association Annual Scientific Sessions 2005, United States: American Heart Association.
  • Ingles, J., Doolan, A., Chiu, C., Seidman, J., Seidman, C., Semsarian, C. (2005). Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. Journal of Medical Genetics, 42(10), 1-6. [More Information]
  • Megevand, A., Ingles, J., Richmond, D., Semsarian, C. (2005). Long-term follow-up of patients with obstructive hypertrophic cardiomyopathy treated with dual-chamber pacing. The American Journal of Cardiology, 95(8), 991-993. [More Information]
  • Wolf, C., Moskowitz, I., Arno, S., Branco, D., Semsarian, C., Bernstein, S., Peterson, M., Maida, M., Morley, G., Fishman, G., et al (2005). Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 102(50), 18123-18128. [More Information]

2004

  • Doolan, A., Langlois, N., Semsarian, C. (2004). Causes Of Sudden Cardiac Death In Young Australians. Medical Journal of Australia, 180(3), 110-112.
  • Doolan, A., Nguyen, L., Semsarian, C. (2004). Hypertrophic Cardiomyopathy: From "Heart Tumour" To A Complex Molecular Genetic Disorder. Heart, Lung and Circulation, 13(1), 15-25.
  • Jayatilleke, I., Doolan, A., Ingles, J., McGuire, M., Booth, V., Richmond, D., Semsarian, C. (2004). Long-Term Follow-Up Of Implantable Cardioverter Defibrillator Therapy For Hypertrophic Cardiomyopathy. The American Journal of Cardiology, 93(9), 1192-1194. [More Information]
  • Doolan, G., Nguyen, L., Chung, J., Ingles, J., Semsarian, C. (2004). Progression Of Left Ventricular Hypertrophy And The Angiotensin-Converting Enzyme Gene Polymorphism In Hypertrophic Cardiomyopathy. International Journal of Cardiology, 96(2), 157-163.

2003

  • Schmitt, J., Semsarian, C., Arad, M., Gannon, J., Ahmad, F., Duffy, C., Lee, R., Seidman, C., Seidman, J. (2003). Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomypathy. Circulation, 108(9), 1133-1138.
  • Chung, M., Tsoutsman, T., Semsarian, C. (2003). Hypertrophic cardiomyopathy: from gene defect to clinical disease. Cell Research, 13(1), 9-20.
  • Jayatilleke, I., McGuire, M., Booth, V., Richmond, D., Semsarian, C. (2003). Sudden death prevented in hypertrophic cardiomyopathy. Heart, Lung and Circulation, 12(3), 196-198.

2002

  • Semsarian, C. (2002). Stem cells in cardiovascular disease: from cell biology to clinical therapy. Internal Medicine Journal, 32(5-6), 259-265.

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