Associate Professor Chris John Jackson
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Director, Sutton Laboratories
E25 - Royal North Shore Hospital |
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Themes
Obesity, Diabetes and Cardiovascular Disease; Infection and Immunological Conditions; Chronic disease and ageing
Research interests
Dr Jackson's research focuses on cellular and molecular mechanisms of inflammation. We have a special interest in two groups of enzymes known as the matrix metalloproteinases and the serine proteases. Novel molecular biological techniques are used to manipulate cellular systems. Some interesting recent discoveries have come from our work investigating the mechanisms of action of one of these enzymes, activated protein C (APC). Our experiments using cultured cells and animal wounding models provide very strong evidence that APC accelerates wound healing. This work extends beyond cutaneous ulcers and has application to the healing of other tissues such as cartilage and bone that have been damaged by either disease, such as arthritis, or injury. Currently we are running 2 clinical trials to examine the efficacy of APC to treat chronic leg ulcers and burns.
Two provisional patent applications for new therapeutic interventions have arisen from work performed in the Sutton laboratories.
Current national competitive grants*
2012
Efficacy of Activated protein C to treat Diabetic Leg ulcers - a randomised, controlled clinical trial
Jackson C, Fulcher G, Wraight P, March L, Cooper A
NHMRC Project Grants ($500,496 over 3 years)
2010
Role of Activated protein C in treatment of bisphosphonate-induced diseases including osteonecrosis of the jaw
Jackson C, Park S, Sambrook P
Korean Research Foundation Research Support ($93,000 over 3 years)
* Grants administered through the University of Sydney
International links
Japan. (Department of Immunology, Saga Medical School, Nabeshima, Saga, Japan) Prof Fukudome provides essential tools and advice for our research on wound healing, arthritis and diabetes..
Canada. (to be declared) Prof David Hart is collaborating with us on the use of animal models for wound healing.