Dr Chris Jolly

Research Fellow
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

C39 - Royal Prince Alfred Hospital
The University of Sydney
NSW 2006 Australia

T: 02 95656188
F: 02 9565 6101
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Biographical details

PhD: Macquarie University/CSIRO, Sydney - 1993 [More...]

Research interests

My group studies antibody mutation in activated B cells, which is initiated by the DNA editing enzyme "AID". B cells mutate their antibody genes at extremely high rates during infections, to rapidly optimise the ability of the antibodies they make to neutralise the infecting pathogen. "Off-target" many adult B cell cancers, so we seek to understand why AID-induced DNA damage leads to mutation, when similar DNA damage is generally repaired faithfully.

Teaching areas

B cell development. Antibody gene rearrangement and mutation.

Current national competitive grants*

2011

Regulation of the quality of DNA repair by timing in the cell cycle
Jolly C
National Health and Medical Research Council Project Grant ($452,957 over 3 years)

* Grants administered through the University of Sydney