Dr Chris Jolly

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Themes | Biographical details | Research interests | Teaching areas | Grants | Honours project opportunities | Keywords

Themes

Cancer; Infection and Immunological Conditions; Healthy Ageing

Biographical details

Research interests

My group studies antibody mutation in activated B cells, which is initiated by the DNA editing enzyme "AID". B cells mutate their antibody genes at extremely high rates during infections, to rapidly optimise the ability of the antibodies they make to neutralise the infecting pathogen. "Off-target" many adult B cell cancers, so we seek to understand why AID-induced DNA damage leads to mutation, when similar DNA damage is generally repaired faithfully.

Teaching areas

B cell development. Antibody gene rearrangement and mutation.

Current national competitive grants*

2011

Regulation of the quality of DNA repair by timing in the cell cycle
Jolly C
National Health and Medical Research Council Project Grant ($452,957 over 3 years)

* Grants administered through the University of Sydney

Honours project opportunities

Cell cycle regulation of DNA damage and repair in activated B cells
Screening for drugs to inhibit AID, a key contributor to B cell neoplasia
Mapping translocations in pre-cancerous human B cells

Keywords

Immunology; Biochemistry; Molecular biology; Ageing; Mutation

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