Professor Clare Fraser
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Professor Clare Fraser

Professor of Neuro-ophthalmology
Faculty of Medicine and Health
Clinical Ophthalmology and Eye Health
Save Sight Institute
Phone
+61 2 9382 7111
Fax
+61 2 93827395
Professor Clare Fraser

Professor Clare Fraser is a clinician-researcher at the University of Sydney's Save Sight Institute. She is involved in the clinical care of patients, researching the best ways to diagnose and manage neuro-ophthalmic eye conditions as well as being involved in teaching. She is a consultant Visiting Medical Officer at both Sydney Eye Hospital and Liverpool Hospital, and is also in private practice in Sydney.

Dr Fraser has sub-speciality interests in Neuro-Ophthalmology, adult strabismus and clinical electrophysiology.

She completed ophthalmic training at Sydney Eye Hospital in 2006-2009 and went on to further Neuro-Ophthalmic training at Moorfields Eye Hospital and the National Hospital for Neurology, London, England, with Dr Gordon Plant for 18 months. In 2011 she completed a research fellowship at Emory Eye Centre, Atlanta, USA, with Drs Nancy Newman and Valerie Biousse.

Dr Fraser is the Vice President of the The Neuro-Ophthalmology Society of Australia, and is one of their Education Officers. She is also the past chair of the North American Neuro-Ophthalmology Society International Relations Committee and is on the committee for the Neuro-Ophthalmology Virtual Education Library. She is on the editorial boards for the Journal of Neuro-Ophthalmology, Neuro-Ophthalmology and Clinical and Experimental Ophthalmology. Dr Fraser is on the board of directors of the Royal Australian and New Zealand College of Ophthalmologists.

In 2017 and 2024 Dr Fraser was the convenor for the Australian Neuro-Ophthalmology Society meeting in Sydney. She is also a Neuro-Ophthalmology faculty member for APAO and WOC.

Dr Fraser has published over 140 articles in peer-reviewed journals, has written several book chapters including chapters on Optic Neuritis and on Pituitary Tumours. She is a reviewer for Journal of Neuro-Ophthalmology, Clinical and Experimental Ophthalmology as well as the American Journal of Ophthalmology. Her research has been awarded with an Ophthalmic Institute of Australia grant, and has won several international awards including the North American Neuro-Ophthalmology Society prize for the best research presentations in 2005, 2006 and 2011.

My research interests include clinical Neuro-Ophthalmology and strabismus, particularly orphan and rare diseases. As part of the investigation of Neuro-Ophthalmic conditions, I focus on how the use of clinical electrophysiology of vision can help in the diagnosis and monitoring of disease outcomes. Some particular research topics have included concussion, optic disc drusen, visual snow syndrome, optic neuritis and idiopathic intracranial hypertension.

Dr Fraser is one of the course co-ordinators for the Masters of Medicine (Ophthalmic Science).

https://www.sydney.edu.au/courses/courses/pc/master-of-medicine-ophthalmic-science.html

She also teaches the next generation of eye doctors and medical students.

Concussion assessment using changes in the visual pathways

Ocular electrophysiology in optic neuritis

Retinal vascular changes in obstructive sleep apnea and cardiac LVAD patients

Optic disc drusen

Visual field rehabilitation

Giant cell arteritis

Fellow of Royal Australian and New Zealand College of Ophthalmologists

Fellow of North American Neuro-ophthalmology Society

Member Neuro-ophthalmology Society of Australia

Australian Vision Research grant 2025

NANOS Pilot Grant 2019

RANCZO/AVANT Leadership Development grant 2017

CDIP, Univerity of Sydney Grant (Visual field rehabilitation)

Jobs NSW MVP grant 2017

HCF Catalyst grant 2016-7

MQ Research Development Grant (MQRDG) Scheme 2017

Arthritis Australia Translational Grant, 2017

St Vincent’s AMR Grant, 2016

Curran Foundation Research Grant, 2015

North American Neuro-ophthalmology Walsh Case award, 2011

RANZCO Eye Foundation Scholarship, 2011

Sydney Eye Alumni Travelling Fellowship Grant, 2010

Ophthalmic Research Institute of Australia Grant, 2006

North American Neuro-ophthalmology Award, 2005 and 2006

University of Sydney Postgraduate Award Scholarship, 2004-2005

MS Society Australia, Young Researcher Award, 2004

Neurosciences and Mental Health, Healthy Ageing
Project titleResearch student
Clinical and immunological biomarker profiling to improve the diagnosis of acute uveitisSerge GEARA

Publications

Book Chapters

  • Skalicky, S., Petsoglou, C., Gurbaxani, A., Fraser, C., McCluskey, P. (2015). New Agents for Treating Dry Eye Syndrome. In M. A. Babizhayev, D. W.-C. Li, A. Kasus-Jacobi, L. Zoric and J. L. Alio (Eds.), Studies on the Cornea and Lens, (pp. 115-129). New York: Springer. [More Information]

Journals

  • Sathianvichitr, K., Vignal-Clermont, C., Fraser, C., Hamann, S., Newman, N., Biousse, V., Milea, D., Najjar, R., Zhiqun, T., Fraser, J., et al (2024). A Deep learning approach for accurate discrimination between optic disc drusen and papilledema on fundus photographs. Journal of Neuro-Ophthalmology, , 10.1097/WNO.0000000000002223. [More Information]
  • Biousse, V., Newman, N., Fraser, C., Micieli, J., Costello, F., Bénard-Séguin, É., Yang, H., Chan, C., Cheung, C., Chan, N., et al (2024). Application of a Deep Learning System to Detect Papilledema on Nonmydriatic Ocular Fundus Photographs in an Emergency Department. American Journal of Ophthalmology, 261, 199-207. [More Information]
  • Lal, A., Fraser, C., White, O., Van Der Walt, A., Dimmick, S., Roche, O., Wang, W., Sheth, S., Chakrabarti, R., Del Porto, L., et al (2024). Developing a Quality Assurance Framework for Neuro-Ophthalmology Using a Multisite Data Registry. Journal of Neuro-Ophthalmology, 44(2), 267-272. [More Information]

2024

  • Sathianvichitr, K., Vignal-Clermont, C., Fraser, C., Hamann, S., Newman, N., Biousse, V., Milea, D., Najjar, R., Zhiqun, T., Fraser, J., et al (2024). A Deep learning approach for accurate discrimination between optic disc drusen and papilledema on fundus photographs. Journal of Neuro-Ophthalmology, , 10.1097/WNO.0000000000002223. [More Information]
  • Biousse, V., Newman, N., Fraser, C., Micieli, J., Costello, F., Bénard-Séguin, É., Yang, H., Chan, C., Cheung, C., Chan, N., et al (2024). Application of a Deep Learning System to Detect Papilledema on Nonmydriatic Ocular Fundus Photographs in an Emergency Department. American Journal of Ophthalmology, 261, 199-207. [More Information]
  • Lal, A., Fraser, C., White, O., Van Der Walt, A., Dimmick, S., Roche, O., Wang, W., Sheth, S., Chakrabarti, R., Del Porto, L., et al (2024). Developing a Quality Assurance Framework for Neuro-Ophthalmology Using a Multisite Data Registry. Journal of Neuro-Ophthalmology, 44(2), 267-272. [More Information]

2023

  • Bartimote, C., Hoskin, A., Fraser, C., Watson, S. (2023). Burn related globe and adnexal trauma at trauma centres. Burns. [More Information]
  • Girard, M., Panda, S., Tun, T., Wibroe, E., Najjar, R., Aung, T., Thiery, A., Hamann, S., Fraser, C., Milea, D. (2023). Discriminating between Papilledema and Optic Disc Drusen Using 3D Structural Analysis of the Optic Nerve Head. Neurology, 100(2), E192-E202. [More Information]
  • Sakti, D., Cornish, E., Fraser, C., Nash, B., Sandercoe, T., Jones, M., Rowe, N., Jamieson, R., Johnson, A., Grigg, J. (2023). Early recognition of CLN3 disease facilitated by visual electrophysiology and multimodal imaging. Documenta Ophthalmologica, 146(3), 241-256. [More Information]

2022

  • Kim, J., Choi, H., Jeon, H., Fraser, C., Mollan, S. (2022). Clinical Characteristics for Predicting Recovery of Acquired Fourth Cranial Nerve Palsy. Journal of Neuro-Ophthalmology, 42(2), 234-238. [More Information]
  • Buch, K., Bouffard, M., Kardon, R., Wills, A., Privitera, C., Sharma, M., Wray, S., Fraser, C., Mollan, S. (2022). Clinical Correlation Between Vertical Gaze Palsy and Midbrain Volume in Progressive Supranuclear Palsy. Journal of Neuro-Ophthalmology, 42(2), 246-250. [More Information]
  • Hepschke, J., Seymour, R., He, W., Etchell, A., Sowman, P., Fraser, C. (2022). Cortical oscillatory dysrhythmias in visual snow syndrome: a magnetoencephalography study. Brain Communications, 4(1). [More Information]

2021

  • Xiong, J., Sammel, A., Laurent, R., Fraser, C. (2021). Diagnostic utility of the chewing gum test in giant cell arteritis. Clinical and Experimental Ophthalmology, 49(1), 83-84. [More Information]
  • Lopez Sanchez, M., Kearns, L., Staffieri, S., Clarke, L., McGuinness, M., Meteoukki, W., Samuel, S., Ruddle, J., Chen, C., Fraser, C., et al (2021). Establishing risk of vision loss in Leber hereditary optic neuropathy. American Journal of Human Genetics, 108(11), 2159-2170. [More Information]
  • Fraser, C., Lueck, C. (2021). Illusions, hallucinations, and visual snow. Handbook of Clinical Neurology, 178, 311-335. [More Information]

2020

  • Gunasekaran, P., Hodge, C., Pearce, A., King, D., Fraser, C. (2020). A review of concussion diagnosis and management in Australian professional sporting codes. The Physician and Sportsmedicine, 48(1), 1-7. [More Information]
  • Milea, D., Najjar, R., Zhubo, J., Ting, D., Vasseneix, C., Xu, X., Fard, M., Fonseca, P., Vanikieti, K., Lagrèze, W., Fraser, C., et al (2020). Artificial intelligence to detect papilledema from ocular fundus photographs. New England Journal of Medicine, 382(18), 1687-1695. [More Information]
  • Arsiwalla, T., Cornish, E., Nguyen, P., Korsakova, M., Ali, H., Saakova, N., Fraser, C., Jamieson, R., Grigg, J. (2020). Assessing residual cone function in retinitis pigmentosa patients. Translational Vision Science and Technology, 9(13), 1-12. [More Information]

2019

  • Tea, F., Lopez, J., Ramanathan, S., Merheb, V., Lee, F., Zou, A., Pilli, D., Patrick, E., van der Walt, A., Monif, M., Tantsis, E., Fraser, C., Reddel, S., Barnett, M., Brown, D., Dale, R., Brilot-Turville, F., et al (2019). Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination. Acta Neuropathologica Communications, 7(1), 1-22. [More Information]
  • Sammel, A., Hsiao, E., Schembri, G., Nguyen, K., Brewer, J., Schrieber, L., Janssen, B., Youssef, P., Fraser, C., Bailey, E., Bailey, D., Roach, P., Laurent, R. (2019). Diagnostic Accuracy of Positron Emission Tomography/Computed Tomography of the Head, Neck, and Chest for Giant Cell Arteritis: A Prospective, Double-Blind, Cross-Sectional Study. Arthritis & Rheumatology, 71(8), 1319-1328. [More Information]
  • Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Zhu, L., Fraser, C., Graham, S., Klistorner, A., et al (2019). Differing Structural and Functional Patterns of Optic Nerve Damage in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder. Ophthalmology, 126(3), 445-453. [More Information]

2018

  • Kelman, J., Kamien, B., Murray, N., Goel, H., Fraser, C., Grigg, J. (2018). A sibling study of isolated optic neuropathy associated with novel variants in the ACO2 gene. Ophthalmic Genetics, 39(5), 648-651. [More Information]
  • Marinos, E., Buzzard, K., Fraser, C., Reddel, S. (2018). Evaluating the temperature effects of ice and heat tests on ptosis due to Myasthenia Gravis. Eye, 32(8), 1387-1391. [More Information]
  • Holmes, R., Lung, T., Fulde, G., Fraser, C. (2018). Fewer orbital fractures treated at St Vincent's Hospital after lockout laws introduced in Sydney. Medical Journal of Australia, 208(4), 174. [More Information]

2017

  • Sammel, A., Hsiao, E., Schrieber, L., Janssen, B., Youssef, P., Fraser, C., Kuo, C., Dunn, H., Bailey, D., Roach, P., Schembri, G., Laurent, R., et al (2017). Fluorine-18 Fluoro-2-Deoxyglucose Positron Emission Tomography Uptake in the Superficial Temporal and Vertebral Arteries in Biopsy Positive Giant Cell Arteritis. International Journal of Clinical Rheumatology, 23(8), 443. [More Information]
  • Fraser, C., Taylor, S., Reid, K., Ahmad, O., Moster, M. (2017). Of Grave Concern. Survey of Ophthalmology, 62(1), 96-102. [More Information]
  • Tong, J., Golzan, M., Georgevsky, D., Williamson, J., Graham, S., Farah, C., Fraser, C. (2017). Quantitative Retinal Vascular Changes in Obstructive Sleep Apnea. American Journal of Ophthalmology, 182, 72-80. [More Information]

2016

  • Ahmad, K., Fraser, C., Sue, C., Barton, J. (2016). Beyond what the eye can see. Survey of Ophthalmology, 61(5), 674-679. [More Information]
  • Kuo, C., McCluskey, P., Fraser, C. (2016). Chewing gum test for jaw claudication in giant-cell arteritis. New England Journal of Medicine, 374(18), 1794-1795. [More Information]
  • Fraser, C. (2016). Clinically detectable visual field loss. Medicine Today, 7(7), 69-71.

2015

  • Siu, R., Tan, I., Davidson, A., Robertson, A., Fraser, C. (2015). Clinical Reasoning: compressive optic neuropathy secondary to intracranial Rosai-Dorfman disease. Neurology, 85(12), e89-e92. [More Information]
  • Tong, J., Jefferson, N., Chaganti, J., Fraser, C. (2015). Compressive Optic Neuropathy from Allergic Fungal Sinusitis. Neuro-Ophthalmology, 39(5), 236-239. [More Information]
  • Pavlou, M., Acheson, J., Nicolaou, D., Fraser, C., Bronstein, M., Davies, R. (2015). Effect of Developmental Binocular Vision Abnormalities on Visual Vertigo Symptoms and Treatment Outcome. Journal of Neurologic Physical Therapy, 39(4), 215-224. [More Information]

2014

  • Ong, H., Fraser, C., Davagnanam, I., Plant, G. (2014). Acute visual loss in papilloedema: the diagnostic pitfalls. International Ophthalmology, 34(3), 607-612. [More Information]
  • Fraser, C. (2014). Obstructive sleep apnea and optic neuropathy: Is there a link? Current Neurology and Neuroscience Reports, 14(8), 1-9. [More Information]
  • Petzold, A., Wattjes, M., Costello, F., Flores-Rivera, J., Fraser, C., Fujihara, K., Leavitt, J., Marignier, R., Paul, F., Schippling, S., et al (2014). The investigation of acute optic neuritis: a review and proposed protocol. Nature Reviews Neurology, 10(8), 447-458. [More Information]

2013

  • Fraser, C., Bliwise, D., Newman, N., Lamirel, C., Collop, N., Rye, D., Trotti, L., Biousse, V., Bruce, B. (2013). A prospective photographic study of the ocular fundus in obstructive sleep apnea. Journal of Neuro-Ophthalmology, 33(3), 241-246. [More Information]
  • Davagnanam, I., Fraser, C., Miszkiel, K., Daniel, C., Plant, G. (2013). Adult Horner's syndrome: A combined clinical, pharmacological, and imaging algorithm. Eye, 27(3), 291-298. [More Information]
  • Bruce, B., Thulasi, P., Fraser, C., Keadey, M., Ward, A., Heilpern, K., Wright, D., Newman, N., Biousse, V. (2013). Diagnostic accuracy and use of nonmydriatic ocular fundus photography by emergency physicians: phase II of the FOTO-ED study. Annals of Emergency Medicine, 62(1), 28-33.e1. [More Information]

2012

  • Fraser, C., Sanchez, S., Newman, N., Biousse, V. (2012). Cat Scratch Disease. Ophthalmology, 119(7), 1502-1503. [More Information]
  • Fraser, C., Biousse, V., Newman, N. (2012). Minocycline-induced fulminant intracranial hypertension. Archives of Neurology, 69(8), 1067-1070. [More Information]
  • Fraser, C., Davagnanam, I., Radon, M., Plant, G. (2012). The time course and phenotype of Uhthoff phenomenon following optic neuritis. Multiple Sclerosis Journal, 18(7), 1042-1044. [More Information]

2011

  • Chen, C., Lee, A., Campbell, B., Lee, T., Paine, M., Fraser, C., Grigg, J., Markus, R. (2011). Efficacy of Intravenous Tissue-Type Plasminogen Activator in Central Retinal Artery Occlusion : Report From a Randomized, Controlled Trial. Stroke, 42(8), 2229-2234. [More Information]
  • Fraser, C., Holder, G. (2011). Electroretinogram findings in unilateral optic neuritis. Documenta Ophthalmologica, 123(3), 173-178. [More Information]
  • Chen, C., Lee, A., Campbell, B., Paine, M., Lee, T., Fraser, C., Grigg, J., Markus, R., Williams, K., Coster, D. (2011). Study of the efficacy of intravenous tissue plasminogen activator in central retinal artery occlusion. International Journal of Stroke, 6(1), 87-89. [More Information]

2007

  • Klistorner, A., Fraser, C., Garrick, R., Graham, S., Arvind Srinivasan, H. (2007). Correlation between full-field and multifocal VEPs in optic neuritis. Documenta Ophthalmologica, 116(1), 19-27. [More Information]
  • Klistorner, A., Graham, S., Fraser, C., Garrick, R., Nguyen, T., Paine, M., O'Day, J., Grigg, J., Arvind Srinivasan, H., Billson, F. (2007). Electrophysiological evidence for heterogeneity of lesions in optic neuritis. Investigative Ophthalmology and Visual Science, 48(10), 4549-4556. [More Information]

2006

  • Fraser, C., Klistorner, A., Graham, S., Garrick, R., Billson, F., Grigg, J. (2006). Multifocal visual evoked potential analysis of inflammatory or demyelinating optic neuritis. Ophthalmology, 113(2), 315-323. [More Information]
  • Fraser, C., Klistorner, A., Graham, S., Garrick, R., Billson, F., Grigg, J. (2006). Multifocal visual evoked potential latency analysis: predicting progression to multiple sclerosis. JAMA Neurology, 63(6), 847-850. [More Information]

Selected Grants

2018

  • Is Visual Snow a Thalamo-Cortical Dysrhythmia of the visual processing system - a magnetoencephalogram study, Fraser C, North American Neuro-ophthalmology Society/North American Neuro-Ophthalmology Society Pilot Research Grant

2016

  • A phase 2/3, randomized, double masked, sham controlled trial of QPO-1007 delivered by single or multi dose intravitreal injection s to subjects with acute nonarteritic anterior ischemic optic neuropathy NAION Owner: Save Sight, Fraser C, Parexel International (Australia)/Research Support
  • PREVANZ: Phase 111b Radomized, Double Bling, Placebo Controlled, Dose ranging trial of vitimin D3 in patients with a demyelinating event - PrevANZ., Fraser C, Multiple Sclerosis Australia/Research Support

In the media

https://www.mivision.com.au/rising-stars-of-eye-health-celebrated-at-parliament-house/