Dr Clement Loy

Senior Lecturer, Clinical Epidemiology
Public Health, School of Public Health

Telephone + 61 2 9036 9127
Fax +61 2 9351 5049

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Biographical details

Dr Clement Loy is a clinical epidemiologist and cognitive neurologist, with a researchinterest in molecular genetics. He is Director of the Huntington Disease (HD) Service at Westmead, which serves about 75% of people with HD in New South Wales. He is an investigator in a number of NHMRC and NIH funded projects, and clinical trials for people with HD. He likes numbers, went through the Clinical Epidemiology program in the late 1990s, and enjoys teaching clinical epidemiology. He strives to translate evidence into practice and serves on a number of governmental advisory panels, including the Economic Subcommittee of the PBAC.

Selected grants

2012

  • Reducing anti-psychotic use in residential: Huntington Disease as an examplar (REAP-HD); Loy C; National Health and Medical Research Council (NHMRC)/Translating Research into Practice (TRIP) Fellowship.
  • Molecular Genetics of Early Onset Alzheimers Disease; Loy C; Judith Jane Mason and Harold Stannett Williams Memorial Foundation/Medical and Scientific Research Grants.

2011

  • CHDI Cognitive Assessment Battery; Loy C; CHDI Foundation/Research Support.

Selected publications

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Book Chapters

  • Brooks, W., Loy, C., Kwok, J., Schofield, P. (2008). Genetics of Dementia. In Cappa SF, Abutalebi J, Demonet J-F, Fletcher PC , Garrard P (Eds.), Cognitive Neurology- a Clinical Textbook, (pp. 321-348). United States: Oxford University Press.
  • Loy, C., Tomlinson, S., Brew, B. (2005). HIV-related neurological disease in the era of HAART and drug resistance. In Christopher Power, Richard Tidball Johnson (Eds.), Emerging Neurological Infections, (pp. 427-452). US: Taylor and Francis.

Journals

  • Loy, C., Schofield, P., Turner, A., Kwok, J. (2014). Genetics of dementia. The Lancet, 383(9919), 828-840. [More Information]
  • Dobson-Stone, C., Hallupp, M., Loy, C., Thompson, E., Haan, E., Sue, C., Panegyres, P., Razquin, C., Seijo-Martinez, M., Rene, R., et al (2013). C9ORF72 repeat expansion in Australian and Spanish frontotemporal dementia patients. PLoS One, 8(2), 1-6. [More Information]
  • Loy, C., McCusker, E. (2013). Is a Motor Criterion Essential for the Diagnosis of Clinical Huntington Disease? PLoS Currents, 5, 1-9. [More Information]
  • McCusker, E., Gunn, D., Epping, E., Loy, C., Radford, K., Griffith, J., Mills, J., Long, J., Paulsen, J. (2013). Unawareness of motor phenoconversion in Huntington disease. Neurology, 81(13), 1141-1147. [More Information]
  • Poon, S., Poon, J., McGrane, M., Zhou, X., Kwan, P., Zhang, R., Liu, B., Gao, J., Loy, C., Chan, K., Sze, D. (2011). A novel approach in discovering significant interactions from TCM patient prescription data. International Journal of Data Mining and Bioinformatics, 5(4), 353-368. [More Information]
  • Reid, W., Hely, M., Morris, J., Loy, C., Halliday, G. (2011). Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study). Journal of Neurology, Neurosurgery, and Psychiatry, 82(9), 1033-1037. [More Information]
  • Gabery, S., Murphy, K., Schultz, K., Loy, C., McCusker, E., Kirik, D., Halliday, G., Petersen, A. (2010). Changes in Key Hypothalamic Neuropeptide Populations in Huntington Disease Revealed by Neuropathological Analyses. Acta Neophilologica, 120, 777-788. [More Information]
  • Craig, J., Webster, A., Loy, C. (2010). How long should treatments be continued? BMJ, 341, 409-414. [More Information]
  • Loy, C., Lownie, A., McCusker, E. (2010). Huntington's disease. The Lancet, 376(9751), 1463. [More Information]
  • Schofield, E., Halliday, G., Kwok, J., Loy, C., Double, K., Hodges, J. (2010). Low Serum Progranulin Predicts the Presence of Mutations: A Prospective Study. Journal of Alzheimer's Disease, 22(3), 981-984. [More Information]
  • Luty, A., Kwok, J., Dobson-Stone, C., Loy, C., Coupland, K., Karlstrom, H., Sobow, T., Tchorzewska, J., Maruszak, A., Barcikowsk, M., Blair, I., et al (2010). Sigma Nonopioid Intracellular Receptor 1 Mutations Cause Frontotemporal Lobar Degeneration-Motor Neuron Disease. Annals of Neurology, 68(5), 639-649. [More Information]
  • Loy, C., Kril, J., Trollor, J., Kiernan, M., Kwok, J., Vucic, S., Halliday, G., Hodges, J. (2010). The case of a 48 year-old woman with bizarre and complex delusions. Nature Reviews Neurology, 6(3), 175-179. [More Information]
  • Loy, C., Kril, J., Kwok, J., Brooks, W., McCann, H., Isaacs, A., Halliday, G. (2010). Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology. Brain: a journal of neurology, 133(12), e158; author reply e159. [More Information]
  • Barnes, J., Bartlett, J., van de Pol, L., Loy, C., Scahill, R., Frost, C., Thompson, P., Fox, N. (2009). A meta-analysis of hippocampal atrophy rates in Alzheimer’s disease. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 30(11), 1711-1723. [More Information]
  • Omar, R., Sampson, E., Loy, C., Mummery, C., Fox, N., Rossor, M., Warren, J. (2009). Delusions in frontotemporal lobar degeneration. Journal of Neurology, 256(4), 600-607. [More Information]
  • Loy, C., Twigg, S. (2009). Growth factors, AGEing, and the diabetes link in Alzheimer's disease. Journal of Alzheimer's Disease, 16(4), 823-831. [More Information]
  • Loy, C., Schofield, P., Kwok, J. (2009). Reply to Garcia-Gorostiaga, et al. Annals of Neurology, 65(6), 761-762.
  • Zhang, Y., Huang, Y., Sun, X., Han, Z., Loy, C., Wang, Y. (2008). Clinical and imaging features of a Chinese-speaking man with semantic dementia. Journal of Neurology, 255(2), 297-298. [More Information]
  • Kwok, J., Loy, C., Hamilton, G., Lau, E., Hallupp, M., Williams, J., Owen, M., Broe, G., Tang, N., Lam, L., Schofield, P., et al (2008). Glycogen synthase kinase-3β and tau genes interact in Alzheimer's disease. Annals of Neurology, 64(4), 446-454. [More Information]
  • Luty, A., Kwok, J., Thompson, E., Blumbergs, P., Brooks, W., Loy, C., Dobson-Stone, C., Panegyres, P., Hecker, J., Nicholson, G., et al (2008). Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9. BMC Neurology, 8(32), 1-11. [More Information]
  • Orth, J., Tang, Y., Shi, J., Loy, C., Amendt, C., Wilm, C., Zenke, F., Mitchison, T. (2008). Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Molecular Cancer Therapeutics, 7(11), 3480-3489. [More Information]
  • Drake, A., Loy, C., Brew, B., Chen, T., Petoumenos, K., Li, P., Wright, E. (2007). Human immunodeficiency virus-associated progressive multifocal leucoencephalopathy: Epidemiology and predictive factors for prolonged survival. European Journal of Neurology, 14(4), 418-423. [More Information]
  • Rami, L., Loy, C., Hailstone, J., Warren, J. (2007). Odor identification in Frontotemporal Lobar Degeneration. Journal of Neurology, 254(4), 431-435. [More Information]
  • Whitwell, J., Sampson, E., Loy, C., Warren, J., Rossor, M., Fox, N., Warren, J. (2007). VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration. NeuroImage, 35(1), 207-213. [More Information]
  • Loy, C., Schneider, L. (2006). Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database of Systematic Reviews, CD001747(1), 1747 - 1-1747 -110. [More Information]
  • Pickering-Brown, S., Baker, M., Gass, J., Boeve, B., Loy, C., Brooks, W., Mackenzie, I., Martins, R., Kwok, J., Halliday, G., Kril, J., et al (2006). Mutations in Progranulin explain atypical phenotypes associated with variants in the MAPT. Brain, 129(11), 3124-3126. [More Information]
  • Kwok, J., Hallupp, M., Loy, C., Chan, D., Woo, J., Mellick, G., Buchanan, D., Silburn, P., Halliday, G., Schofield, P. (2005). GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Annals of Neurology, 58(6), 829-839. [More Information]
  • Loy, C., Sweeney, M., Davis, M., Wills, A., Sawle, G., Lees, A., Tabrizi, S. (2005). Spinocerebellar ataxia type 17: Extension of phenotype with putaminal rim hyperintensity on magnetic resonance imaging. Movement Disorders, 20(11), 1521-1523. [More Information]
  • Loy, C., Irwig, L. (2004). Accuracy Of Diagnostic Tests Read With And Without Clinical Information: A Systematic Review. JAMA: The Journal of the American Medical Association, 292(13), 1602-1609. [More Information]
  • Kwok, J., Teber, E., Hallupp, M., Nicholson, G., Mellick, G., Buchanan, D., Silburn, P., Loy, C., Schofield, P. (2004). Tau Haplotypes Regulate Transcription And Are Associated With Parkinson'S Disease. Annals of Neurology, 55(3), 329-334. [More Information]
  • Houssami, N., Irwig, L., Loy, C. (2002). Accuracy of combined breast imaging in young women. The Breast, 11(1), 36-40.

Conferences

  • Petersen, H., Poon, J., Poon, S., Loy, C., Leeflang, M. (2013). Partially automated literature screening for systematic reviews by modelling non-relevant articles. Third Australasian Workshop on Artificial Intelligence in Health (AIH 2013) in conjuntion with the 26th Australasian Joint Conference on Artificial Intelligence (AI 2013), Dunedin, New Zealand: CEUR-WS.
  • Poon, S., Fan, K., Poon, J., Loy, C., Chan, K., Kuan, P., Zhou, X., Gao, J., Zhang, R., Wang, Y., et al (2011). Analysis of herbal formulation in TCM: Infertility as a case study. IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW 2011), Los Alamitos, CA, USA: (IEEE) Institute of Electrical and Electronics Engineers. [More Information]
  • McGrane, M., Poon, S., Poon, J., Chan, K., Loy, C., Zhou, X., Zhang, R., Liu, B., Kwan, P., Sze, D., et al (2010). Analysis of Synergistic and Antagonistic Effects of TCM: Cases on Diabetes and Insomnia. 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops BIBMW 2010, USA: (IEEE) Institute of Electrical and Electronics Engineers.
  • Poon, J., Poon, S., Yin, D., Chan, K., Loy, C., Zhou, X., Zhang, R., Liu, B., Kwan, P., Sze, D., et al (2010). Studying Herb-Herb Interaction for Insomnia through the theory of Complementarities. 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops BIBMW 2010, USA: (IEEE) Institute of Electrical and Electronics Engineers.

2014

  • Loy, C., Schofield, P., Turner, A., Kwok, J. (2014). Genetics of dementia. The Lancet, 383(9919), 828-840. [More Information]

2013

  • Dobson-Stone, C., Hallupp, M., Loy, C., Thompson, E., Haan, E., Sue, C., Panegyres, P., Razquin, C., Seijo-Martinez, M., Rene, R., et al (2013). C9ORF72 repeat expansion in Australian and Spanish frontotemporal dementia patients. PLoS One, 8(2), 1-6. [More Information]
  • Loy, C., McCusker, E. (2013). Is a Motor Criterion Essential for the Diagnosis of Clinical Huntington Disease? PLoS Currents, 5, 1-9. [More Information]
  • Petersen, H., Poon, J., Poon, S., Loy, C., Leeflang, M. (2013). Partially automated literature screening for systematic reviews by modelling non-relevant articles. Third Australasian Workshop on Artificial Intelligence in Health (AIH 2013) in conjuntion with the 26th Australasian Joint Conference on Artificial Intelligence (AI 2013), Dunedin, New Zealand: CEUR-WS.
  • McCusker, E., Gunn, D., Epping, E., Loy, C., Radford, K., Griffith, J., Mills, J., Long, J., Paulsen, J. (2013). Unawareness of motor phenoconversion in Huntington disease. Neurology, 81(13), 1141-1147. [More Information]

2011

  • Poon, S., Poon, J., McGrane, M., Zhou, X., Kwan, P., Zhang, R., Liu, B., Gao, J., Loy, C., Chan, K., Sze, D. (2011). A novel approach in discovering significant interactions from TCM patient prescription data. International Journal of Data Mining and Bioinformatics, 5(4), 353-368. [More Information]
  • Poon, S., Fan, K., Poon, J., Loy, C., Chan, K., Kuan, P., Zhou, X., Gao, J., Zhang, R., Wang, Y., et al (2011). Analysis of herbal formulation in TCM: Infertility as a case study. IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW 2011), Los Alamitos, CA, USA: (IEEE) Institute of Electrical and Electronics Engineers. [More Information]
  • Reid, W., Hely, M., Morris, J., Loy, C., Halliday, G. (2011). Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study). Journal of Neurology, Neurosurgery, and Psychiatry, 82(9), 1033-1037. [More Information]

2010

  • McGrane, M., Poon, S., Poon, J., Chan, K., Loy, C., Zhou, X., Zhang, R., Liu, B., Kwan, P., Sze, D., et al (2010). Analysis of Synergistic and Antagonistic Effects of TCM: Cases on Diabetes and Insomnia. 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops BIBMW 2010, USA: (IEEE) Institute of Electrical and Electronics Engineers.
  • Gabery, S., Murphy, K., Schultz, K., Loy, C., McCusker, E., Kirik, D., Halliday, G., Petersen, A. (2010). Changes in Key Hypothalamic Neuropeptide Populations in Huntington Disease Revealed by Neuropathological Analyses. Acta Neophilologica, 120, 777-788. [More Information]
  • Craig, J., Webster, A., Loy, C. (2010). How long should treatments be continued? BMJ, 341, 409-414. [More Information]
  • Loy, C., Lownie, A., McCusker, E. (2010). Huntington's disease. The Lancet, 376(9751), 1463. [More Information]
  • Schofield, E., Halliday, G., Kwok, J., Loy, C., Double, K., Hodges, J. (2010). Low Serum Progranulin Predicts the Presence of Mutations: A Prospective Study. Journal of Alzheimer's Disease, 22(3), 981-984. [More Information]
  • Luty, A., Kwok, J., Dobson-Stone, C., Loy, C., Coupland, K., Karlstrom, H., Sobow, T., Tchorzewska, J., Maruszak, A., Barcikowsk, M., Blair, I., et al (2010). Sigma Nonopioid Intracellular Receptor 1 Mutations Cause Frontotemporal Lobar Degeneration-Motor Neuron Disease. Annals of Neurology, 68(5), 639-649. [More Information]
  • Poon, J., Poon, S., Yin, D., Chan, K., Loy, C., Zhou, X., Zhang, R., Liu, B., Kwan, P., Sze, D., et al (2010). Studying Herb-Herb Interaction for Insomnia through the theory of Complementarities. 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops BIBMW 2010, USA: (IEEE) Institute of Electrical and Electronics Engineers.
  • Loy, C., Kril, J., Trollor, J., Kiernan, M., Kwok, J., Vucic, S., Halliday, G., Hodges, J. (2010). The case of a 48 year-old woman with bizarre and complex delusions. Nature Reviews Neurology, 6(3), 175-179. [More Information]
  • Loy, C., Kril, J., Kwok, J., Brooks, W., McCann, H., Isaacs, A., Halliday, G. (2010). Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology. Brain: a journal of neurology, 133(12), e158; author reply e159. [More Information]

2009

  • Barnes, J., Bartlett, J., van de Pol, L., Loy, C., Scahill, R., Frost, C., Thompson, P., Fox, N. (2009). A meta-analysis of hippocampal atrophy rates in Alzheimer’s disease. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 30(11), 1711-1723. [More Information]
  • Omar, R., Sampson, E., Loy, C., Mummery, C., Fox, N., Rossor, M., Warren, J. (2009). Delusions in frontotemporal lobar degeneration. Journal of Neurology, 256(4), 600-607. [More Information]
  • Loy, C., Twigg, S. (2009). Growth factors, AGEing, and the diabetes link in Alzheimer's disease. Journal of Alzheimer's Disease, 16(4), 823-831. [More Information]
  • Loy, C., Schofield, P., Kwok, J. (2009). Reply to Garcia-Gorostiaga, et al. Annals of Neurology, 65(6), 761-762.

2008

  • Zhang, Y., Huang, Y., Sun, X., Han, Z., Loy, C., Wang, Y. (2008). Clinical and imaging features of a Chinese-speaking man with semantic dementia. Journal of Neurology, 255(2), 297-298. [More Information]
  • Brooks, W., Loy, C., Kwok, J., Schofield, P. (2008). Genetics of Dementia. In Cappa SF, Abutalebi J, Demonet J-F, Fletcher PC , Garrard P (Eds.), Cognitive Neurology- a Clinical Textbook, (pp. 321-348). United States: Oxford University Press.
  • Kwok, J., Loy, C., Hamilton, G., Lau, E., Hallupp, M., Williams, J., Owen, M., Broe, G., Tang, N., Lam, L., Schofield, P., et al (2008). Glycogen synthase kinase-3β and tau genes interact in Alzheimer's disease. Annals of Neurology, 64(4), 446-454. [More Information]
  • Luty, A., Kwok, J., Thompson, E., Blumbergs, P., Brooks, W., Loy, C., Dobson-Stone, C., Panegyres, P., Hecker, J., Nicholson, G., et al (2008). Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9. BMC Neurology, 8(32), 1-11. [More Information]
  • Orth, J., Tang, Y., Shi, J., Loy, C., Amendt, C., Wilm, C., Zenke, F., Mitchison, T. (2008). Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Molecular Cancer Therapeutics, 7(11), 3480-3489. [More Information]

2007

  • Drake, A., Loy, C., Brew, B., Chen, T., Petoumenos, K., Li, P., Wright, E. (2007). Human immunodeficiency virus-associated progressive multifocal leucoencephalopathy: Epidemiology and predictive factors for prolonged survival. European Journal of Neurology, 14(4), 418-423. [More Information]
  • Rami, L., Loy, C., Hailstone, J., Warren, J. (2007). Odor identification in Frontotemporal Lobar Degeneration. Journal of Neurology, 254(4), 431-435. [More Information]
  • Whitwell, J., Sampson, E., Loy, C., Warren, J., Rossor, M., Fox, N., Warren, J. (2007). VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration. NeuroImage, 35(1), 207-213. [More Information]

2006

  • Loy, C., Schneider, L. (2006). Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database of Systematic Reviews, CD001747(1), 1747 - 1-1747 -110. [More Information]
  • Pickering-Brown, S., Baker, M., Gass, J., Boeve, B., Loy, C., Brooks, W., Mackenzie, I., Martins, R., Kwok, J., Halliday, G., Kril, J., et al (2006). Mutations in Progranulin explain atypical phenotypes associated with variants in the MAPT. Brain, 129(11), 3124-3126. [More Information]

2005

  • Kwok, J., Hallupp, M., Loy, C., Chan, D., Woo, J., Mellick, G., Buchanan, D., Silburn, P., Halliday, G., Schofield, P. (2005). GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Annals of Neurology, 58(6), 829-839. [More Information]
  • Loy, C., Tomlinson, S., Brew, B. (2005). HIV-related neurological disease in the era of HAART and drug resistance. In Christopher Power, Richard Tidball Johnson (Eds.), Emerging Neurological Infections, (pp. 427-452). US: Taylor and Francis.
  • Loy, C., Sweeney, M., Davis, M., Wills, A., Sawle, G., Lees, A., Tabrizi, S. (2005). Spinocerebellar ataxia type 17: Extension of phenotype with putaminal rim hyperintensity on magnetic resonance imaging. Movement Disorders, 20(11), 1521-1523. [More Information]

2004

  • Loy, C., Irwig, L. (2004). Accuracy Of Diagnostic Tests Read With And Without Clinical Information: A Systematic Review. JAMA: The Journal of the American Medical Association, 292(13), 1602-1609. [More Information]
  • Kwok, J., Teber, E., Hallupp, M., Nicholson, G., Mellick, G., Buchanan, D., Silburn, P., Loy, C., Schofield, P. (2004). Tau Haplotypes Regulate Transcription And Are Associated With Parkinson'S Disease. Annals of Neurology, 55(3), 329-334. [More Information]

2002

  • Houssami, N., Irwig, L., Loy, C. (2002). Accuracy of combined breast imaging in young women. The Breast, 11(1), 36-40.

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