Emeritus Professor Cristobal Dos Remedios

Emeritus Professor
Anatomy & Histology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 3209
Fax +61 2 9351 6546

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Research interests

Molecular basis of human heart failure

International links

China

(Professor Xiyun Yan, National Key Laboratory of Biomolecules,Institute of Biophysics, Chinese Academy of Sciences Datun Road No.15, Beijing 100101) Research collaboration involving the use of a monoclonal anti-CD146 antibody to identify the role of CD146 in human heart failure.

France

(Inserm U915, Institut du Thorax, Nantes Faculte de Medecine) Research collaboration between Dr Marja Steenman, my laboratory and a graduate student, Maurizio Stefani.

Germany

(Dr. Wolfgang A. Linke, Department of Cardiovascular Physiology, Institute of Physiology, Faculty of Medicine Ruhr University Bochum. D-44780 Bochum) Collaboration with Dr Wolfgang Linke on the role of protein kinase G in modulating the passive stiffness of phosphorylated titin, a giant protein component of the cardiomyocyte.

Ireland

(Michael J. Dunn, PhD, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin 4) Research collaboration involving the protective effect of phosphorylated Hsp27 in human coronary arteries through actin stabilisation

Ireland

(University College Dublin) Working with Prof. Michael Dunn

Japan

(Shin''ichi Ishiwata, Ph.D., Professor of Biophysics, Department of Physics, School of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555) Awarded a JSRS Travel grant to visit in September 2008. In 2009 we commenced a collaborative, working on SPontaneous Oscilatory Contractions (SPOCs) as a method of quantifying functional deficits in end-stage failing human cardiomyocytes.

Netherlands

(D.Dooijes, PhD., Clinical Molecular Geneticist Department of of Clinical Genetics, Erasmus Medical College, Dr. Molewaterplein 50, 3015GE, ROTTERDAM) Collaboration involving the genotyping og familial heart failure in man.

Netherlands

(Institute for Cardiovascular Research. Free University Amsterdam) Collaboration with Jolanda Van Der Velden and others in her laboratory

Sweden

(University of Uppsala, HPR Research Group, Rudbeck Laboratory, Dag Hammarskjold 20 S-751-85, Uppsala) Research collaboration with Prof Fredrik Ponten involving the use of tissue microarrays of failing and non-failing human hearts.

United Kingdom

(Ayesha De Souza, PhD, Department of Cardiac & Vascular Sciences, St. George''s Hospital, University of London, Cranmer Terrace Tooting, London, SW17 0RE) Research collaboration involving proteomic and metabolomic analysis of failing human left atria to reveal the molecular mechanism underlying atrial fibrillation.

United Kingdom

(Dr Michael Gray, Epithelial Research Group, Institute for Cell and Molecular Biosciences, University Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH) Research collaboration involving the role of a protein kinase called sgk1 in human heart failure.

United Kingdom

(Elizabeth Ehler PhD., Kings College London BHF Research Excellence Centre, The Randall Division of Cell and Molecular Biophysics, New Hunts House, Guys Campus, London SE1 1UL) Research collaboration involving measurement of expression levels of a muscle-specific isoform of the formin (FHOD3) in the human heart and its role in myofibril maintenance

United Kingdom

(Imperial College London) Collaborating with Prof Steve Marston on molecular defects in failing human cardiac proteins, particularly the proteins that regulate contraction in the heart.

United Kingdom

(Jonathan C. Kentish, MA, PhD Cardiovascular Division,King''s College London Rayne Institute, St. Thomas''s Hospital, London SE1 7EH) Collaborating involving a study of normal passive viscoelasticity but abnormal myofibrillar contractile function in patients with obstructive hypertrophic cardiomyopathy.

United Kingdom

(Paul Riley PhD, Molecular Medicine Unit, UCL-Institute of Child Health, 30 Guilford Street, London, WC1N 1EH) Research collaboration involving hypertrophic cardiomyopathy (HOCM) myectomy heart samples to study transcriptional/microRNA regulation of sarcomeric gene expression in human heart failure.

United States

(Anne M. Murphy MD, The Johns Hopkins University Medical School, 720 Rutland Avenue Ross Bldg. 1144, Baltimore, MD 21205) Research collaboration involving mutations in cardiac troponin I in failing and non-failing human left ventricles.

United States

(Bernhard Kuhn, MD, PhD, Harvard Children''s Hospital, 61 Binney Street, Enders 1329, Boston MA 02115) Research collaboration with this laboratory involving a study of growth, proliferation and regeneration in the human heart from infancy to senescence.

United States

(Director, Long QT Syndrome Clinic and Windland Smith Rice Sudden Death Genomics Laboratory Mayo Clinic) Research collaboration into molecular changes in hypertrophic cardiomyopathy in human hearts

United States

(Harvard Children's Hospital, Cardiology) Collaboration with Dr Bill Pu working on microRNAs and human heart failure

United States

(Harvard Medical School) working with Prof Paul Allen

United States

(Johns Hopkins University Medical School, Division of Cardiology, Biological Chemistry and Biomedical Engineering) Working with Prof Jennifer Van Eyk on proteomics of failing human hearts

United States

(Lilehei Heart Inst, Division of Cardiology, University of Minnesota) Collaboration with Prof Jennifer Hall working on transcriptomics of failing human hearts

United States

(William Pu, PhD Department of Cardiology, Children''s Hospital Enders 13,300 Longwood Ave., Boston, MA 02115) Research collaboration involving the role of splicing variants of cardiac proteins in human heart failure

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.

2012

  • Upgrade of the Palm Duoflex Combi Laser Microdissection and Optical Tweezers System to a High-resolution and Improved Live-cell Imaging Platform using an Apotome.2 Slider and Associated Software; Cole L, Mason R, Richardson D, Phillips W, Bao B, Buckland M, Morris M, Dos Remedios C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • International Union for Pure & Applied Physics; Dos Remedios C; International Union for Pure & Applied Physics/Research Support.
  • Surface immobilisation of enzymes for the synthesis of ethanol; McKenzie D, Bilek M, Dos Remedios C, Yasuda H; Australian Research Council (ARC)/Discovery Projects (DP).
  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • Muscle Res Dos Remedios Donation as per Q104; Dos Remedios C; Research Donations/Research Donations.
  • Muscle Res Dos Remedios; Dos Remedios C; Imperial College London/Research Support.
  • Muscle Res Dos Remedios; Dos Remedios C; University of the Mediterranean/Research Support.

2007

  • Fluorescence Applications in Biotechnology and Life Sciences (FABLS); Dos Remedios C; Australian Research Council (ARC)/Research Networks (ARCRN).
  • High-resolution electron tomographic facility for nanoanlytical characterization in the material an; Braet F, Ramzan I, Ringer S, Soon L, Liu Z, Hambley T, Lay P, Warr G, Thordarson P, Murphy C, Dos Remedios C, Weiss A, Parker A; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2006

  • Cardiac Gene Expression Profile Of Ageing; Dos Remedios C; DEST/Innovation Access Programme-International Science&Technology Grants.
  • High resolution bioanalytical Fourier transform mass spectrometer combined with liquid chromatograph; Christopherson R, Baker M, Raftery M, Geczy C, James D, Harry E, Guilhaus M, Cavicchioli R, Stocker R, Wilkinson M, Dos Remedios C, Davey R; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2005

  • Monitoring Psoriasis treatments with protein microarrays; Dos Remedios C, Barnetson R; Psoriasis Australia Inc/Biennial Research Grant.

2004

  • Electric field induced surface attachment & detachment of proteins; McKenzie D, Dos Remedios C, Griesser H; Australian Research Council (ARC)/Discovery Projects (DP).
  • 2100 bioanalyfor multi-user molecular biology facility; Dos Remedios C; Clive & Vera Ramaciotti Foundation/Research Grant.
  • Detection of conformational changes in actin and myosin using fluoresence spectroscopy; Moens P, Dos Remedios C; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Leica inverted research microscope with photographic attachment; Dos Remedios C; Clive & Vera Ramaciotti Foundation/Project Support.
  • Lipids and the actin cytoskeleton; Dos Remedios C; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • Ultrasec 3100 pro: UV-vis spectrophotmeter; Mason R, Byrne M, Dos Remedios C, Keay K, Lovicu F; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • RC L3022 - Diagnosis of leukaemias by CD antigen expression & Protocol No X02-0056 & RC K0301- Inflammation and CD antigen expression: cardiopulmonary bypass v OPCAB surgery; Dos Remedios C, Christopherson R; Medsaic Pty Ltd/BLO Project.
  • Probing the function of protein molecular motors on nano-fabricated structures; Dos Remedios C; Australian Research Council (ARC)/Discovery Projects (DP).
  • Inverted micro-nano-fluidics devices using protein molecular motors; Dos Remedios C; Swinburne University/Research Grant.
  • Inverted micro/nano-fluidics devices using protein molecular motors; Dos Remedios C; Defence Advanced Research Projects Agency/Research Grants.

2001

  • The role of cofilin in regulating the actin cytoskeleton; Dos Remedios C, King G; Australian Research Council (ARC)/Large Research Grants (LRG).

2000

  • A molecular device for the detection of aqueous environmental pollution; Filshie B, Hourigan M, Dos Remedios C; Hermon Slade Foundation/BLO Project.
  • Analysis of structure and function of actin and myosin using fluorescence spectroscopy; Dos Remedios C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Fluorescence activated cell sorter; Morris B, Dos Remedios C, Mason R; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
  • Advanced networked PCR system: multi-block system for the control of polymerase chain reaction work in a multi-user environment; Stone J, Dos Remedios C; Clive & Vera Ramaciotti Foundation/Research Grants.
  • A new regulatory mechanism for the actin cytoskeleton; Dos Remedios C; Australian Research Council (ARC)/Small Grants.
  • Signalling pathway of cardiomyocyte apoptosis in failing hearts; Jiang L, Dos Remedios C; National Heart Foundation/Research Grant.

Selected publications

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Edited Books

  • Dos Remedios, C., Chhabra, D. (2008). Actin-Binding Proteins and Disease. New York: Springer Science + Business Media.
  • Dos Remedios, C., Qin, Z., Shi, Y. (2006). The Amazing Human Body:the anatomical display of real human bodies. Australia: Redtail.
  • Dos Remedios, C., Thomas, D. (2002). Molecular Interactions of Actin; Actin-Myosin Interaction & Actin-Based Regulation. United States: Springer.

Book Chapters

  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.
  • Stefani, M., Tsubakihara, M., Hambly, B., Liew, C., Allen, P., Macdonald, P., Dos Remedios, C. (2008). Actin and its binding proteins in heart failure. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. 318-334). New York: Springer Science + Business Media.
  • Chhabra, D., Dos Remedios, C. (2008). Actin: an overview of its structure and function. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. 1-16). New York: Springer Science + Business Media.
  • Dos Remedios, C., Nosworthy, N. (2008). The role of PIP2 in actin, actin-binding proteins and disease. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. 290-297). New York: Springer Science + Business Media.
  • Lui, R., Brown, A., Wu, B., Lin, M., Thompson, J., Braet, F., Dyer, W., Lattimore, J., Macdonald, P., Adelstein, S., Dos Remedios, C. (2008). Use of Antibody Microarrays in the Analysis of Inflammation, Autoimmunity, Viral Infection, and Cancer Metastases. In J. E. Van Eyk and M. J. Dunn (Eds.), Clinical Proteomics: From Diagnosis to Therapy, (pp. 571-592). Weinheim: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Dos Remedios, C., Chhabra, D. (2007). Foreword. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. v-vii). New York: Springer Science + Business Media.
  • Dos Remedios, C., Thomas, D. (2001). An overview of actin structure and actin-binding proteins. In Cristobal G. Dos Remedios & David D. Thomas (Eds.), Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins, (pp. 1-7). Germany: Springer.
  • Dos Remedios, C., Moens,, P. (2001). Analysis of models of F-Actin using fluorescence resonance energy transfer spectroscopy. In Cristobal G. Dos Remedios & David D. Thomas (Eds.), Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins, (pp. 59-76). Germany: Springer.
  • Kekic, M., Nosworthy, N., Dedova, I., Collyer, C., Dos Remedios, C. (2001). Regulation of the cytoskeleton assembly: a role for a ternary complex of actin with two actin-binding proteins. In Cristobal G. Dos Remedios & David D. Thomas (Eds.), Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins, (pp. 165-177). Germany: Springer.

Journals

  • Kosobrodova, E., Mohamed, A., Su, Y., Kondyurin, A., Dos Remedios, C., McKenzie, D., Bilek, M. (2014). Cluster of differentiation antibody microarrays on plasma immersion ion implanted polycarbonate. Materials Science and Engineering C: Materials for Biological Applications, 35(1), 434-440. [More Information]
  • Marsman, R., Bezzina, C., Freiberg, F., Verkerk, A., Adriaens, M., Podliesna, S., Chen, C., Purfürst, B., Spallek, B., Koopmann, T., Dos Remedios, C., et al (2014). Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia. Journal of the American College of Cardiology, 63(6), 549-559. [More Information]
  • Witjas-Paalberends, E., Gulcu, A., Germans, T., Knaapen, P., Harms, H., Vermeer, A., Christiaans, I., Wilde, A., Dos Remedios, C., Lammertsma, A., et al (2014). Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations. Cardiovascular Research, 103(2), 248-257. [More Information]
  • Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PLoS One, 9(5), 1-11. [More Information]
  • Lin, M., Ho, J., Harrison, L., Dos Remedios, C., Adelstein, S. (2013). An antibody-based leukocyte-capture microarray for the diagnosis of systemic lupus erythematosus. PLoS One, 8(3), 1-8. [More Information]
  • Mollova, M., Bersell, K., Walsh, S., Savla, J., Das, L., Park, S., Silberstein, L., Dos Remedios, C., Graham, D., Colan, S., et al (2013). Cardiomyocyte proliferation contributes to heart growth in young humans. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 110(4), 1446-1451. [More Information]
  • Hamdani, N., Krysiak, J., Kreusser, M., Neef, S., Dos Remedios, C., Maier, L., Krüger, M., Backs, J., Linke, W. (2013). Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circulation Research, 112(4), 664-674. [More Information]
  • Velonas, V., Woo, H., Dos Remedios, C., Assinder, S. (2013). Current Status of Biomarkers for Prostate Cancer. International Journal of Molecular Sciences, 14(6), 11034-11060. [More Information]
  • Kotter, S., Gout, L., Von Frieling-Salewsky, M., Muller, A., Helling, S., Marcus, K., Dos Remedios, C., Linke, W., Kruger, M. (2013). Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts. Cardiovascular Research, 99(4), 648-656. [More Information]
  • Memo, M., Leung, M., Ward, D., Dos Remedios, C., Morimoto, S., Zhang, L., Ravenscroft, G., McNamara, E., Nowak, K., Marston, S., et al (2013). Familial dilated cardiomyopathy mutations uncouple troponin l phosphorylation from changes in myofibrillar Ca2+ sensitivity. Cardiovascular Research, 99(1), 65-73. [More Information]
  • Hall, D., Dos Remedios, C. (2013). Foreword to the biophysics of protein-protein and protein-ligand interactions in dilute and crowded media—a special issue in honor of Allen Minton’s 70th birthday. Biophysical Reviews, 5(2), 57-60. [More Information]
  • Cordell, H., Bentham, J., Topf, A., Zelenika, D., Heath, S., Mamasoula, C., Cosgrove, C., Blue, G., Granados-Riveron, J., Setchfield, K., Dos Remedios, C., Winlaw, D., et al (2013). Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nature Genetics, 45(7), 822-824. [More Information]
  • Kuster, D., Sequeira, V., Najafi, A., Boontje, N., Wijnker, P., Paalberends, R., Marston, S., Dos Remedios, C., Carrier, L., Demmers, J., et al (2013). GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communication. Circulation Research, 112(4), 633-639. [More Information]
  • Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung and Circulation, 22(10), 819-826. [More Information]
  • Wijnker, P., Foster, D., Tsao, A., Frazier, A., Dos Remedios, C., Murphy, A., Stienen, G., van der Velden, J. (2013). Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 304(2), H260-H268. [More Information]
  • Hirsh, S., Bilek, M., Bax, D., Kondyurin, A., Kosobrodova, E., Tsoutas, K., Tran, C., Waterhouse, A., Yin, Y., Nosworthy, N., McKenzie, D., Dos Remedios, C., Weiss, A., et al (2013). Ion Implanted, Radical-Rich Surfaces For The Rapid Covalent Immobilization Of Active Biomolecules. AIP Conference Proceedings, 1525, 364-369. [More Information]
  • Kuster, D., Mulders, J., ten Cate, F., Michels, M., Dos Remedios, C., da Costa Martins, P., van der Velden, J., Oudejans, C. (2013). MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations. Journal of Molecular and Cellular Cardiology, 65, 59-66. [More Information]
  • Witjas-Paalberends, E., Piroddi, N., Stam, K., Van Dijk, S., Sequeira Oliviera, V., Ferrara, C., Scellini, B., Hazebroek, M., ten Cate, F., van Slegtenhorst, M., Dos Remedios, C., et al (2013). Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy. Cardiovascular Research, 99, 432-441. [More Information]
  • Bayliss, C., Jacques, A., Leung, M., Ward, D., Redwood, C., Gallon, C., Copeland, O., McKenna, W., Dos Remedios, C., Marston, S., et al (2013). Myofibrillar Ca(2+) sensitivity is uncoupled from troponin l phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T. Cardiovascular Research, 97(3), 500-508. [More Information]
  • Sequeira, V., Wijnker, P., Nijenkamp, L., Kuster, D., Najafi, A., Witjas-Paalberends, E., Regan, J., Boontje, N., Ten Cate, F., Germans, T., Dos Remedios, C., et al (2013). Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. Circulation Research, 112(11), 1491-1505. [More Information]
  • Kooij, V., Zhang, P., Piersma, S., Sequeira, V., Boontje, N., Wijnker, P., Jimenez, C., Jaquet, K., Dos Remedios, C., Murphy, A., et al (2013). PKCα-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis. PLoS One, 8(10), 1-10. [More Information]
  • Rain, S., Handoko, L., Trip, P., Gan, T., Westerhof, N., Stienen, G., Paulus, W., Ottenheijm, C., Marcus, T., Dorfmuller, P., Dos Remedios, C., et al (2013). Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension. Circulation, 128(18), 2016-2025. [More Information]
  • Wiggers, W., Olson, W., Dos Remedios, C. (2012). Computational opportunities for remote collaboration and capacity building afforded by Web 2.0 and cloud computing. Biophysical Reviews, 4(3), 153-160. [More Information]
  • van Dijk, S., Paalberends, R., Najafi, A., Michels, M., Sadayappan, S., Carrier, L., Boontje, N., Kuster, D., van Slegtenhorst, M., Dooijes, D., Dos Remedios, C., et al (2012). Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function. Circulation. Heart Failure, 5(1), 36-46. [More Information]
  • Ling, L., Khammy, O., Byrne, M., Amirahmadi, F., Foster, A., Li, G., Zhang, L., Dos Remedios, C., Chen, C., Kaye, D. (2012). Irregular rhythm adversely influences calcium handling in ventricular myocardium. Circulation. Heart Failure, 5(6), 786-793. [More Information]
  • Zhang, P., Kirk, J., Ji, W., Dos Remedios, C., Kass, D., van Eyk, J., Murphy, A. (2012). Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart. Circulation, 126(15), 1828-1837. [More Information]
  • Li, A., Ponten, F., Dos Remedios, C. (2012). The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development. Proteomics, 12(2), 203-225. [More Information]
  • Polden, J., McManus, C., Dos Remedios, C., Dunn, M. (2011). A 2-D gel reference map of the basic human heart proteome. Proteomics, 11(17), 3582-3586. [More Information]
  • Foreman, A., Phillips, L., Kanellis, V., Hammoudeh, D., Naumann, C., Wong, H., Chisari, R., Hibbert, D., Lee, G., Patra, R., Dos Remedios, C., et al (2011). A DNA-based assay for toxic chemicals in wastewater. Environmental Toxicology and Chemistry, 30(8), 1810-1818. [More Information]
  • Morales, M., Dos Remedios, C. (2011). Biophysical educational experiment: science and goodwill in Latin America and Africa. Biophysical Reviews, 3, 101-106. [More Information]
  • Bilek, M., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Fisher, K., Waterhouse, A., Weiss, A., Dos Remedios, C., McKenzie, D. (2011). Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(35), 14405-14410. [More Information]
  • Hirsh, S., Nosworthy, N., Kondyurin, A., Dos Remedios, C., McKenzie, D., Bilek, M. (2011). Linker-free covalent thermophilic b-glucosidase functionalized polymeric surfaces. Journal of Materials Chemistry, 21, 17832-17841. [More Information]
  • Maeder, M., Khammy, O., Dos Remedios, C., Kaye, D. (2011). Myocardial and Systemic Iron Depletion in Heart Failure: Implications for Anemia Accompanying Heart Failure. Journal of the American College of Cardiology, 58(5), 474-480. [More Information]
  • Wijnker, P., Boknik, P., Gergs, U., Muller, F., Neumann, J., Dos Remedios, C., Schmitz, W., Sindermann, J., Stienen, G., van der Velden, J., et al (2011). Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium. Journal Of Muscle Research And Cell Motility, 32(3), 221-233. [More Information]
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]
  • Changsirivathanathamrong, D., Wang, Y., Rajbhandari, D., Maghzal, G., Mak, W., Woolfe, C., Duflou, J., Gebski, V., Dos Remedios, C., Celermajer, D., Stocker, R. (2011). Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Critical Care Medicine, 39(12), 2678-2683. [More Information]
  • Hirsh, S., Bilek, M., Nosworthy, N., Kondyurin, A., Dos Remedios, C., McKenzie, D. (2010). A Comparison of Covalent Immobilization and Physical Adsorption of a Cellulase Enzyme Mixture. Langmuir, 26(17), 14380-14388. [More Information]
  • Ho, J., Lin, M., Adelstein, S., Dos Remedios, C. (2010). Customising an antibody leukocyte capture microarray for systemic lupus erythematosus: Beyond biomarker discovery. Proteomics - Clinical Applications, 4(2), 179-189. [More Information]
  • Kooij, V., Saes, M., Jaquet, K., Zaremba, R., Foster, D., Murphy, A., Dos Remedios, C., van der Velden, J., Stienen, G. (2010). Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background. Journal of Molecular and Cellular Cardiology, 48(5), 954-963. [More Information]
  • Iskratsch, T., Lange, S., Dwyer, J., Kho, A., Dos Remedios, C., Ehler, E. (2010). Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. The Journal of Cell Biology, 191(6), 1159-1172. [More Information]
  • Kong, S., Hu, Y., Ho, J., Ikeda, S., Polster, S., John, R., Hall, J., Bisping, E., Pieske, B., Dos Remedios, C., et al (2010). Heart Failure-Associated Changes in RNA Splicing of Sarcomere Genes. Circulation: Cardiovascular Genetics, 3(2), 138-146. [More Information]
  • Kwok, D., Tong, L., Yeung, C., Dos Remedios, C., Chu, P. (2010). Hybrid plasma surface modification and ion implantation of biopolymers. Surface and Coatings Technology, 204(18-19), 2892-2897. [More Information]
  • Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]
  • Hamdani, N., Borbely, A., Veenstra, S., Kooij, V., Vrydag, W., Zaremba, R., Dos Remedios, C., Niessen, H., Michel, M., Paulus, W., et al (2010). More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease. Journal Of Muscle Research And Cell Motility, 31(4), 289-301. [More Information]
  • Hoskins, A., Jacques, A., Bardswell, S., McKenna, W., Tsang, V., Dos Remedios, C., Ehler, E., Adams, K., Jalilzadeh, S., Avkiran, M., et al (2010). Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 49(5), 737-745. [More Information]
  • Lu, Z., Xu, X., Hu, X., Lee, S., Traverse, J., Zhu, G., Fassett, J., Tao, Y., Zhang, P., Dos Remedios, C., et al (2010). Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation, 121(13), 1474-1483. [More Information]
  • Robinson, A., Dunn, M., McCormack, A., Dos Remedios, C., Rose, M. (2010). Protective effect of phosphorylated Hsp27 in coronary arteries through actin stabilization. Journal of Molecular and Cellular Cardiology, 49(3), 370-379. [More Information]
  • Kooij, V., Boontje, N., Zaremba, R., Jaquet, K., Dos Remedios, C., Stienen, G., van der Velden, J. (2010). Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardium. Basic Research in Cardiology, 105(2), 289-300. [More Information]
  • Ho, J., Stefani, M., Dos Remedios, C., Charleston, M. (2009). A model selection approach to discover age-dependent gene expression patterns using quantile regression models. BMC Genomics, 10(Suppl 3), S16-1-S16-18. [More Information]
  • van Dijk, S., Holewijn, R., Tebeest, A., Dos Remedios, C., Stienen, G., van der Velden, J. (2009). A piece of the human heart: variance of protein phosphorylation in left ventricular samples from end-stage primary cardiomyopathy patients. Journal Of Muscle Research And Cell Motility, 30(7-Aug), 299-302. [More Information]
  • Van Dijk, S., Dooijes, D., Dos Remedios, C., Michels, M., Lamers, J., Winegrad, S., Schlossarek, S., Carrier, L., ten Cate, F., Stienen, G., et al (2009). Cardiac myosin-binding protein C mutations and hypertrophic ardiomyopathy haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction. Circulation, 119(11), 1473-1483. [More Information]
  • Estigoy, C., Ponten, F., Odeberg, J., Herbert, B., Guilhaus, M., Charleston, M., Ho, J., Cameron, D., Dos Remedios, C. (2009). Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts. Biophysical Reviews, 1(1), 43-49. [More Information]
  • Dos Remedios, C., Yamane, M., Hughes, J., Stefani, M., Fukuda, N., Kurihara, S., Steenman, M., Ishiwata, S. (2009). SPOC: A Functional Assay of Failing and Non-Failing Human Cardiomyocytes. Biophysical Journal, 96(3 Suppl 1), 224a.
  • Dos Remedios, C., Yamane, M., Robinson, J., Hughes, J., Stefani, M., Fukuda, N., Kurihara, S., Steenman, M., Ishiwata, S. (2009). Spontaneous Oscillatory Contraction: A Functional Assay of Contractile Function of Human Heart Samples Stored at -190 ºC. Heart, Lung and Circulation, 18(3), S311-S311.
  • Messer, A., Gallon, C., McKenna, W., Dos Remedios, C., Marston, S. (2009). The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle. Proteomics - Clinical Applications, 3, 1371-1382. [More Information]
  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]
  • Martinez-Neira, R., Dos Remedios, C., Mackay, I. (2008). An actin-myosin functional assay for analysis of smooth muscle (anti-microfilament) autoantibodies in human plasma. Journal of Immunological Methods, 338(1-2), 63-66. [More Information]
  • Ho, J., Stefani, M., Dos Remedios, C., Charleston, M. (2008). Differential variability analysis of gene expression and its application to human diseases. Bioinformatics, 24(doi:10.1093/bioinformatics/btn142), i390-i398. [More Information]
  • Ho, J., Koundinya, R., Caetano, T., Dos Remedios, C., Charleston, M. (2008). Inferring differential leukocyte activity from antibody microarrays using a latent variable model. Genome Informatics, 21(1), 126-137. [More Information]
  • Hamdani, N., Waard, M., Messer, A., Boontje, N., Kooij, V., van Dijk, S., Versteilen, A., Lamberts, R., Merkus, D., Dos Remedios, C., et al (2008). Myofilament dysfunction in cardiac disease from mice to men. Journal Of Muscle Research And Cell Motility, 29(6-Aug), 189-201. [More Information]
  • Kruger, M., Kotter, S., Grutzner, A., Lang, P., Andresen, C., Redfield, M., Butt, E., Dos Remedios, C., Linke, W. (2008). Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs. Circulation Research, 104(1), 87-94. [More Information]
  • Hamdani, N., Kooij, V., van Dijk, S., Merkus, D., Paulus, W., Dos Remedios, C., Duncker, D., Stienen, G., van der Velden, J. (2008). Sarcomeric dysfunction in heart failure. Cardiovascular Research, 77(4), 649-658. [More Information]
  • Fermin, D., Barac, A., Lee, S., Polster, S., Hannenhalli, S., Bergemann, T., Grindle, S., Dyke, D., Pagani, F., Dos Remedios, C., et al (2008). Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure. Circulation: Cardiovascular Genetics, 1(2), 117-125. [More Information]
  • Brown, A., Lattimore, J., McGrady, M., Sullivan, D., Dyer, W., Braet, F., Dos Remedios, C. (2008). Stable and unstable angina: Identifying novel markers on circulating leukocytes. Proteomics - Clinical Applications, 2, 90-98. [More Information]
  • Dos Remedios, C. (2007). New and Notable: The regulation of muscle contraction: As in life, it keeps getting more complex. Biophysical Journal, 93(12), 4097-8. [More Information]
  • Gan, B., Nosworthy, N., McKenzie, D., Dos Remedios, C., Bilek, M. (2007). Plasma immersion ion implantation treatment of polyethylene for enhanced binding of active horseradish peroxidase. Journal of Biomedical Materials Research. Part A, 85A(3), 605-610. [More Information]
  • Ho, J., Nosworthy, N., Bilek, M., Gan, B., McKenzie, D., Chu, P., Dos Remedios, C. (2007). Plasma-treated polyethylene surfaces for improved binding of active protein. Plasma Processes and Polymers, 4(5), 583-590. [More Information]
  • Zhang, L., Merkus, D., Hamdani, N., Lamers, J., Paulus, W., Dos Remedios, C., Duncker, D., Stienen, G., van der Velden, J. (2007). Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies. Proteomics - Clinical Applications, 1, 1285-1290.
  • Nicolau, D., Solana, G., Kekic, M., Fulga, F., Mahanivong, C., Wright, S., Dos Remedios, C. (2007). Surface Hydrophobicity modulates the operation of actomyosin-based dynamic nanodevices. Langmuir, 23(21), 10846-10854. [More Information]
  • Narolska, N., Piroddi, N., Belus, A., Boontje, N., Scellini, B., Deppermann, S., Zaremba, R., Musters, R., Dos Remedios, C., Jaquet, K., Murphy, A., et al (2006). Impaired Diastolic Function After Exchange of Endogenous Troponin I with C-Terminal Truncated Troponin I in Human Cardiac Muscle. Circulation Research, 99(9), 1012-1020. [More Information]
  • Gorbatyuk, V., Nosworthy, N., Robson, S., Bains, N., Maciejewski, M., Dos Remedios, C., King, G. (2006). Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction. Molecular Cell, 24(4), 511-522.
  • Steel, B., McKenzie, D., Bilek, M., Nosworthy, N., Dos Remedios, C. (2006). Nanosecond responses of proteins to ultra-high temperature pulses. Biophysical Journal, 91(6), L66-L68. [More Information]
  • Dedova, I., Nikolaeva, O., Safer, D., De La Cruz, E., Dos Remedios, C. (2006). Thymosin beta4 induces a conformational change in actin monomers. Biophysical Journal, 90(3), 985-992. [More Information]
  • Martinez-Neira, R., Kekic, M., Nicolau, D., Dos Remedios, C. (2005). A novel biosensor for mercuric ions based on motor proteins. Biosensors and Bioelectronics, 20(7), 1428-1432. [More Information]
  • Chhabra, D., Dos Remedios, C. (2005). Cofilin, actin and their complex observed in vivo using fluorescence resonance energy transfer. Biophysical Journal, 89(3), 1902-1908. [More Information]
  • Chhabra, D., Dos Remedios, C. (2005). Intracellular fluorescence resonance energy transfer. Biophysical Journal, 89, 1902-1908.
  • Jiang, L., Bardini, M., Keogh, A., Dos Remedios, C., Burnstock, G. (2005). P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium. International Journal of Cardiology, 98(2), 291-297. [More Information]
  • Chhabra, D., Nosworthy, N., Dos Remedios, C. (2005). The N-terminal fragment of gelsolin inhibits the interaction of DNase I with isolated actin, but not with the cofilin-actin complex. Proteomics, 5(12), 3131-3136. [More Information]
  • Steel, B., Bilek, M., Dos Remedios, C., McKenzie, D. (2004). Apparatus For Exposing Cell Membranes To Rapid Temperature Transients. European Biophysics Journal, 33(2), 117-120. [More Information]
  • Tsubakihara, M., Williams, N., Keogh, A., Dos Remedios, C. (2004). Comparison Of Gene Expression Between Left Atria And Left Ventricles From Non-Diseased Humans. Proteomics, 4(1), 261-270.
  • Dedova, I., Dos Remedios, C. (2004). Conformational changes of actin induced by strong or weak myosin subfragment-1 binding. Tsitologiya, 46(8), 719-734. [More Information]
  • Borovikov, Y., Dedova, I., Dos Remedios, C., Vikhoreva, N., Vikhorev, P., Avrova, S., Hazlett, T., Van Der Meer, B. (2004). Fluorescence Depolarization Of Actin Filaments In Reconstructed Myofibers: The Effect Of S1 Or pPDM-S1 On Movements Of Distinct Areas Of Actin. Biophysical Journal, 86(5), 3020-3029.
  • Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]
  • Dedova, I., Nikolaeva, O., Mikhailova, V., Dos Remedios, C., Levitsky, D. (2004). Two Opposite Effects Of Cofilin On The Thermal Unfolding Of F-Actin: A Differential Scanning Calorimetric Study. Biophysical Chemistry, 110(1-2), 119-128. [More Information]
  • Dos Remedios, C., Chhabra, D., Kekic, M., Dedova, I., Tsubakihara, M., Berry, A., Nosworthy, N. (2003). Actin binding proteins: Regulation of cytoskeletal microfilaments. Physiological Reviews, 83, 433-473.
  • Ng, D., Court, N., Dos Remedios, C., Bogoyevitch, M. (2003). Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts. Cardiovascular Research, 57, 333-346.
  • Dunn, T., Heller, C., McCarthy, S., Dos Remedios, C. (2003). Anatomical study of the "Trochanteric Bursa". Clinical Anatomy, 16(3), 233-240. [More Information]
  • Steel, B., Bilek, M., Dos Remedios, C., McKenzie, D. (2003). Apparatus for exposing cell membranes to rapid temperature transients. European Biophysics Journal, 11, 117-120.
  • Jiang, L., Huang, Y., Hunyor, S., Dos Remedios, C. (2003). Cardiomyocyte apoptosis is associated with increased wall stress in chronic failing left ventricle. European Heart Journal, 24, 742-751.
  • Dos Remedios, C., Liew, C., Allen, P., Winslow, R., Van Eyk, J., Dunn, M. (2003). Genomics, proteomics and bioinformatics of human heart failure. Journal Of Muscle Research And Cell Motility, 24(4-6), 251-260.
  • Steel, B., Bilek, M., McKenzie, D., Dos Remedios, C. (2002). A technique for microsecond heating & cooling of a thin (submicron) biological sample. European Biophysics Journal, 31(5), 378-382. [More Information]
  • Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149.
  • Court, N., Dos Remedios, C., Cordell, J., Bogoyevitch, M. (2002). Cardiac expression & subcellular localization of the p38 Mitogen-activated protein kinase member, stress-activated protein kinases-3 (SAPK3). Journal of Molecular and Cellular Cardiology, 34(4), 413-426.
  • Dedova, I., Dedov, V., Nosworthy, N., Hambly, B., Dos Remedios, C. (2002). Cofilin and DNase 1 affect the conformation of the small domain of actin. Biophysical Journal, 82, 3134-3143.
  • Heller, C., Marucci, D., Dunn, T., Barr, E., Houang, M., Dos Remedios, C. (2002). Inguinal canal 'Lipoma'. Clinical Anatomy, , 280-285. [More Information]
  • Bains, N., Gorbatyuk, V., Nosworthy, N., Robson, S., Maciejewski, M., Dos Remedios, C., King, G. (2002). Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin. Journal of Biomolecular NMR, 22(2), 193-194.
  • Mahanivong, C., Wright, J., Kekic, M., Pham, D., Dos Remedios, C., Nicolau, D. (2002). Manipulation of the motility of protein molecular motors on microfabricated substrates. Biomedical Microdevices, 4(2), 111-116.
  • Chhabra, D., Bao, B., Dos Remedios, C. (2002). The distribution of cofilin and DNase I in vivo. Cell Research, 12(3-4), 207-214.
  • Heinke, M., Yao, M., Chang, D., Einstein, R., Dos Remedios, C. (2001). Apoptosis of ventricular and atrial myocytes from pacing-induced canine heart failure. Cardiovascular Research, 49 (1), 127-134.
  • Jiang, L., Tsubakihara, M., Heinke, M., Phillips, W., Dos Remedios, C., Nosworthy, N., Yao, M. (2001). Heart failure and apoptosis: Electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics. Proteomics, 1 (12), 1481-1488.
  • Belov, L., de la Vega, O., Dos Remedios, C., Christopherson, R., Mulligan,, S. (2001). Immunophenotyping of leukemias using a cluster of differentiation antibody microarray. Cancer Research, 61(11), 4483-4489.
  • Berry, D., Dos Remedios, C., Keogh, A. (2001). Nuclear membrane proteins in failing human dilated cardiomyopathy. Proteomics, 1 (12), 1507-1512.
  • Nosworthy, N., Kekic, M., Dos Remedios, C. (2001). The affinity of chick cofilin for actin increases when actin is complexed with DNase 1: Formation of a cofilin-actin-DNase 1 ternary complex. Proteomics, 1 (12), 1513-1518.

Conferences

  • Dos Remedios, C., McKenzie, D., Boswell, R., Lui, R., Bilek, M., Charles, C., Ramdutt, D. (2006). Development of the nanotiter plate for use in antibody and cell array technologies. SPIE - Biomedical Applications of Micro- and Nano-engineering, Australia: SPIE Proceedings.
  • Kekic, M., Dos Remedios, C., Martinez, R., Nicolau, D. (2005). An acto/myosin in vitro motility assay as a motion based sensor. Biophysical Society 49th Annual Meeting, Bethesda, MD: Biophysical Society.
  • Lui, R., Tsubakihara, M., Macdonald, P., Hayward, C., Dos Remedios, C. (2005). Analysing inflammation in heart failure using microarray platforms. 27th Annual Meeting of the American Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press Elsevier.
  • Thordarson, P., Bilek, M., McKenzie, D., Nosworthy, N., Davies, K., Morrow, R., Gan, B., Dos Remedios, C. (2005). Functional Attachment of Horse Radish Peroxidase to Plasma Treated Surfaces. Smart Materials III, : SPIE Press.

2014

  • Kosobrodova, E., Mohamed, A., Su, Y., Kondyurin, A., Dos Remedios, C., McKenzie, D., Bilek, M. (2014). Cluster of differentiation antibody microarrays on plasma immersion ion implanted polycarbonate. Materials Science and Engineering C: Materials for Biological Applications, 35(1), 434-440. [More Information]
  • Marsman, R., Bezzina, C., Freiberg, F., Verkerk, A., Adriaens, M., Podliesna, S., Chen, C., Purfürst, B., Spallek, B., Koopmann, T., Dos Remedios, C., et al (2014). Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia. Journal of the American College of Cardiology, 63(6), 549-559. [More Information]
  • Witjas-Paalberends, E., Gulcu, A., Germans, T., Knaapen, P., Harms, H., Vermeer, A., Christiaans, I., Wilde, A., Dos Remedios, C., Lammertsma, A., et al (2014). Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations. Cardiovascular Research, 103(2), 248-257. [More Information]
  • Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PLoS One, 9(5), 1-11. [More Information]

2013

  • Lin, M., Ho, J., Harrison, L., Dos Remedios, C., Adelstein, S. (2013). An antibody-based leukocyte-capture microarray for the diagnosis of systemic lupus erythematosus. PLoS One, 8(3), 1-8. [More Information]
  • Mollova, M., Bersell, K., Walsh, S., Savla, J., Das, L., Park, S., Silberstein, L., Dos Remedios, C., Graham, D., Colan, S., et al (2013). Cardiomyocyte proliferation contributes to heart growth in young humans. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 110(4), 1446-1451. [More Information]
  • Hamdani, N., Krysiak, J., Kreusser, M., Neef, S., Dos Remedios, C., Maier, L., Krüger, M., Backs, J., Linke, W. (2013). Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circulation Research, 112(4), 664-674. [More Information]
  • Velonas, V., Woo, H., Dos Remedios, C., Assinder, S. (2013). Current Status of Biomarkers for Prostate Cancer. International Journal of Molecular Sciences, 14(6), 11034-11060. [More Information]
  • Kotter, S., Gout, L., Von Frieling-Salewsky, M., Muller, A., Helling, S., Marcus, K., Dos Remedios, C., Linke, W., Kruger, M. (2013). Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts. Cardiovascular Research, 99(4), 648-656. [More Information]
  • Memo, M., Leung, M., Ward, D., Dos Remedios, C., Morimoto, S., Zhang, L., Ravenscroft, G., McNamara, E., Nowak, K., Marston, S., et al (2013). Familial dilated cardiomyopathy mutations uncouple troponin l phosphorylation from changes in myofibrillar Ca2+ sensitivity. Cardiovascular Research, 99(1), 65-73. [More Information]
  • Hall, D., Dos Remedios, C. (2013). Foreword to the biophysics of protein-protein and protein-ligand interactions in dilute and crowded media—a special issue in honor of Allen Minton’s 70th birthday. Biophysical Reviews, 5(2), 57-60. [More Information]
  • Cordell, H., Bentham, J., Topf, A., Zelenika, D., Heath, S., Mamasoula, C., Cosgrove, C., Blue, G., Granados-Riveron, J., Setchfield, K., Dos Remedios, C., Winlaw, D., et al (2013). Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nature Genetics, 45(7), 822-824. [More Information]
  • Kuster, D., Sequeira, V., Najafi, A., Boontje, N., Wijnker, P., Paalberends, R., Marston, S., Dos Remedios, C., Carrier, L., Demmers, J., et al (2013). GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communication. Circulation Research, 112(4), 633-639. [More Information]
  • Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung and Circulation, 22(10), 819-826. [More Information]
  • Wijnker, P., Foster, D., Tsao, A., Frazier, A., Dos Remedios, C., Murphy, A., Stienen, G., van der Velden, J. (2013). Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 304(2), H260-H268. [More Information]
  • Hirsh, S., Bilek, M., Bax, D., Kondyurin, A., Kosobrodova, E., Tsoutas, K., Tran, C., Waterhouse, A., Yin, Y., Nosworthy, N., McKenzie, D., Dos Remedios, C., Weiss, A., et al (2013). Ion Implanted, Radical-Rich Surfaces For The Rapid Covalent Immobilization Of Active Biomolecules. AIP Conference Proceedings, 1525, 364-369. [More Information]
  • Kuster, D., Mulders, J., ten Cate, F., Michels, M., Dos Remedios, C., da Costa Martins, P., van der Velden, J., Oudejans, C. (2013). MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations. Journal of Molecular and Cellular Cardiology, 65, 59-66. [More Information]
  • Witjas-Paalberends, E., Piroddi, N., Stam, K., Van Dijk, S., Sequeira Oliviera, V., Ferrara, C., Scellini, B., Hazebroek, M., ten Cate, F., van Slegtenhorst, M., Dos Remedios, C., et al (2013). Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy. Cardiovascular Research, 99, 432-441. [More Information]
  • Bayliss, C., Jacques, A., Leung, M., Ward, D., Redwood, C., Gallon, C., Copeland, O., McKenna, W., Dos Remedios, C., Marston, S., et al (2013). Myofibrillar Ca(2+) sensitivity is uncoupled from troponin l phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T. Cardiovascular Research, 97(3), 500-508. [More Information]
  • Sequeira, V., Wijnker, P., Nijenkamp, L., Kuster, D., Najafi, A., Witjas-Paalberends, E., Regan, J., Boontje, N., Ten Cate, F., Germans, T., Dos Remedios, C., et al (2013). Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. Circulation Research, 112(11), 1491-1505. [More Information]
  • Kooij, V., Zhang, P., Piersma, S., Sequeira, V., Boontje, N., Wijnker, P., Jimenez, C., Jaquet, K., Dos Remedios, C., Murphy, A., et al (2013). PKCα-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis. PLoS One, 8(10), 1-10. [More Information]
  • Rain, S., Handoko, L., Trip, P., Gan, T., Westerhof, N., Stienen, G., Paulus, W., Ottenheijm, C., Marcus, T., Dorfmuller, P., Dos Remedios, C., et al (2013). Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension. Circulation, 128(18), 2016-2025. [More Information]

2012

  • Wiggers, W., Olson, W., Dos Remedios, C. (2012). Computational opportunities for remote collaboration and capacity building afforded by Web 2.0 and cloud computing. Biophysical Reviews, 4(3), 153-160. [More Information]
  • van Dijk, S., Paalberends, R., Najafi, A., Michels, M., Sadayappan, S., Carrier, L., Boontje, N., Kuster, D., van Slegtenhorst, M., Dooijes, D., Dos Remedios, C., et al (2012). Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function. Circulation. Heart Failure, 5(1), 36-46. [More Information]
  • Ling, L., Khammy, O., Byrne, M., Amirahmadi, F., Foster, A., Li, G., Zhang, L., Dos Remedios, C., Chen, C., Kaye, D. (2012). Irregular rhythm adversely influences calcium handling in ventricular myocardium. Circulation. Heart Failure, 5(6), 786-793. [More Information]
  • Zhang, P., Kirk, J., Ji, W., Dos Remedios, C., Kass, D., van Eyk, J., Murphy, A. (2012). Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart. Circulation, 126(15), 1828-1837. [More Information]
  • Li, A., Ponten, F., Dos Remedios, C. (2012). The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development. Proteomics, 12(2), 203-225. [More Information]

2011

  • Polden, J., McManus, C., Dos Remedios, C., Dunn, M. (2011). A 2-D gel reference map of the basic human heart proteome. Proteomics, 11(17), 3582-3586. [More Information]
  • Foreman, A., Phillips, L., Kanellis, V., Hammoudeh, D., Naumann, C., Wong, H., Chisari, R., Hibbert, D., Lee, G., Patra, R., Dos Remedios, C., et al (2011). A DNA-based assay for toxic chemicals in wastewater. Environmental Toxicology and Chemistry, 30(8), 1810-1818. [More Information]
  • Morales, M., Dos Remedios, C. (2011). Biophysical educational experiment: science and goodwill in Latin America and Africa. Biophysical Reviews, 3, 101-106. [More Information]
  • Bilek, M., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Fisher, K., Waterhouse, A., Weiss, A., Dos Remedios, C., McKenzie, D. (2011). Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(35), 14405-14410. [More Information]
  • Hirsh, S., Nosworthy, N., Kondyurin, A., Dos Remedios, C., McKenzie, D., Bilek, M. (2011). Linker-free covalent thermophilic b-glucosidase functionalized polymeric surfaces. Journal of Materials Chemistry, 21, 17832-17841. [More Information]
  • Maeder, M., Khammy, O., Dos Remedios, C., Kaye, D. (2011). Myocardial and Systemic Iron Depletion in Heart Failure: Implications for Anemia Accompanying Heart Failure. Journal of the American College of Cardiology, 58(5), 474-480. [More Information]
  • Wijnker, P., Boknik, P., Gergs, U., Muller, F., Neumann, J., Dos Remedios, C., Schmitz, W., Sindermann, J., Stienen, G., van der Velden, J., et al (2011). Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium. Journal Of Muscle Research And Cell Motility, 32(3), 221-233. [More Information]
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]
  • Changsirivathanathamrong, D., Wang, Y., Rajbhandari, D., Maghzal, G., Mak, W., Woolfe, C., Duflou, J., Gebski, V., Dos Remedios, C., Celermajer, D., Stocker, R. (2011). Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Critical Care Medicine, 39(12), 2678-2683. [More Information]

2010

  • Hirsh, S., Bilek, M., Nosworthy, N., Kondyurin, A., Dos Remedios, C., McKenzie, D. (2010). A Comparison of Covalent Immobilization and Physical Adsorption of a Cellulase Enzyme Mixture. Langmuir, 26(17), 14380-14388. [More Information]
  • Ho, J., Lin, M., Adelstein, S., Dos Remedios, C. (2010). Customising an antibody leukocyte capture microarray for systemic lupus erythematosus: Beyond biomarker discovery. Proteomics - Clinical Applications, 4(2), 179-189. [More Information]
  • Kooij, V., Saes, M., Jaquet, K., Zaremba, R., Foster, D., Murphy, A., Dos Remedios, C., van der Velden, J., Stienen, G. (2010). Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background. Journal of Molecular and Cellular Cardiology, 48(5), 954-963. [More Information]
  • Iskratsch, T., Lange, S., Dwyer, J., Kho, A., Dos Remedios, C., Ehler, E. (2010). Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. The Journal of Cell Biology, 191(6), 1159-1172. [More Information]
  • Kong, S., Hu, Y., Ho, J., Ikeda, S., Polster, S., John, R., Hall, J., Bisping, E., Pieske, B., Dos Remedios, C., et al (2010). Heart Failure-Associated Changes in RNA Splicing of Sarcomere Genes. Circulation: Cardiovascular Genetics, 3(2), 138-146. [More Information]
  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.
  • Kwok, D., Tong, L., Yeung, C., Dos Remedios, C., Chu, P. (2010). Hybrid plasma surface modification and ion implantation of biopolymers. Surface and Coatings Technology, 204(18-19), 2892-2897. [More Information]
  • Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]
  • Hamdani, N., Borbely, A., Veenstra, S., Kooij, V., Vrydag, W., Zaremba, R., Dos Remedios, C., Niessen, H., Michel, M., Paulus, W., et al (2010). More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease. Journal Of Muscle Research And Cell Motility, 31(4), 289-301. [More Information]
  • Hoskins, A., Jacques, A., Bardswell, S., McKenna, W., Tsang, V., Dos Remedios, C., Ehler, E., Adams, K., Jalilzadeh, S., Avkiran, M., et al (2010). Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 49(5), 737-745. [More Information]
  • Lu, Z., Xu, X., Hu, X., Lee, S., Traverse, J., Zhu, G., Fassett, J., Tao, Y., Zhang, P., Dos Remedios, C., et al (2010). Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation, 121(13), 1474-1483. [More Information]
  • Robinson, A., Dunn, M., McCormack, A., Dos Remedios, C., Rose, M. (2010). Protective effect of phosphorylated Hsp27 in coronary arteries through actin stabilization. Journal of Molecular and Cellular Cardiology, 49(3), 370-379. [More Information]
  • Kooij, V., Boontje, N., Zaremba, R., Jaquet, K., Dos Remedios, C., Stienen, G., van der Velden, J. (2010). Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardium. Basic Research in Cardiology, 105(2), 289-300. [More Information]

2009

  • Ho, J., Stefani, M., Dos Remedios, C., Charleston, M. (2009). A model selection approach to discover age-dependent gene expression patterns using quantile regression models. BMC Genomics, 10(Suppl 3), S16-1-S16-18. [More Information]
  • van Dijk, S., Holewijn, R., Tebeest, A., Dos Remedios, C., Stienen, G., van der Velden, J. (2009). A piece of the human heart: variance of protein phosphorylation in left ventricular samples from end-stage primary cardiomyopathy patients. Journal Of Muscle Research And Cell Motility, 30(7-Aug), 299-302. [More Information]
  • Van Dijk, S., Dooijes, D., Dos Remedios, C., Michels, M., Lamers, J., Winegrad, S., Schlossarek, S., Carrier, L., ten Cate, F., Stienen, G., et al (2009). Cardiac myosin-binding protein C mutations and hypertrophic ardiomyopathy haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction. Circulation, 119(11), 1473-1483. [More Information]
  • Estigoy, C., Ponten, F., Odeberg, J., Herbert, B., Guilhaus, M., Charleston, M., Ho, J., Cameron, D., Dos Remedios, C. (2009). Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts. Biophysical Reviews, 1(1), 43-49. [More Information]
  • Dos Remedios, C., Yamane, M., Hughes, J., Stefani, M., Fukuda, N., Kurihara, S., Steenman, M., Ishiwata, S. (2009). SPOC: A Functional Assay of Failing and Non-Failing Human Cardiomyocytes. Biophysical Journal, 96(3 Suppl 1), 224a.
  • Dos Remedios, C., Yamane, M., Robinson, J., Hughes, J., Stefani, M., Fukuda, N., Kurihara, S., Steenman, M., Ishiwata, S. (2009). Spontaneous Oscillatory Contraction: A Functional Assay of Contractile Function of Human Heart Samples Stored at -190 ºC. Heart, Lung and Circulation, 18(3), S311-S311.
  • Messer, A., Gallon, C., McKenna, W., Dos Remedios, C., Marston, S. (2009). The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle. Proteomics - Clinical Applications, 3, 1371-1382. [More Information]
  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]

2008

  • Stefani, M., Tsubakihara, M., Hambly, B., Liew, C., Allen, P., Macdonald, P., Dos Remedios, C. (2008). Actin and its binding proteins in heart failure. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. 318-334). New York: Springer Science + Business Media.
  • Dos Remedios, C., Chhabra, D. (2008). Actin-Binding Proteins and Disease. New York: Springer Science + Business Media.
  • Chhabra, D., Dos Remedios, C. (2008). Actin: an overview of its structure and function. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. 1-16). New York: Springer Science + Business Media.
  • Martinez-Neira, R., Dos Remedios, C., Mackay, I. (2008). An actin-myosin functional assay for analysis of smooth muscle (anti-microfilament) autoantibodies in human plasma. Journal of Immunological Methods, 338(1-2), 63-66. [More Information]
  • Ho, J., Stefani, M., Dos Remedios, C., Charleston, M. (2008). Differential variability analysis of gene expression and its application to human diseases. Bioinformatics, 24(doi:10.1093/bioinformatics/btn142), i390-i398. [More Information]
  • Ho, J., Koundinya, R., Caetano, T., Dos Remedios, C., Charleston, M. (2008). Inferring differential leukocyte activity from antibody microarrays using a latent variable model. Genome Informatics, 21(1), 126-137. [More Information]
  • Hamdani, N., Waard, M., Messer, A., Boontje, N., Kooij, V., van Dijk, S., Versteilen, A., Lamberts, R., Merkus, D., Dos Remedios, C., et al (2008). Myofilament dysfunction in cardiac disease from mice to men. Journal Of Muscle Research And Cell Motility, 29(6-Aug), 189-201. [More Information]
  • Kruger, M., Kotter, S., Grutzner, A., Lang, P., Andresen, C., Redfield, M., Butt, E., Dos Remedios, C., Linke, W. (2008). Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs. Circulation Research, 104(1), 87-94. [More Information]
  • Hamdani, N., Kooij, V., van Dijk, S., Merkus, D., Paulus, W., Dos Remedios, C., Duncker, D., Stienen, G., van der Velden, J. (2008). Sarcomeric dysfunction in heart failure. Cardiovascular Research, 77(4), 649-658. [More Information]
  • Fermin, D., Barac, A., Lee, S., Polster, S., Hannenhalli, S., Bergemann, T., Grindle, S., Dyke, D., Pagani, F., Dos Remedios, C., et al (2008). Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure. Circulation: Cardiovascular Genetics, 1(2), 117-125. [More Information]
  • Brown, A., Lattimore, J., McGrady, M., Sullivan, D., Dyer, W., Braet, F., Dos Remedios, C. (2008). Stable and unstable angina: Identifying novel markers on circulating leukocytes. Proteomics - Clinical Applications, 2, 90-98. [More Information]
  • Dos Remedios, C., Nosworthy, N. (2008). The role of PIP2 in actin, actin-binding proteins and disease. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. 290-297). New York: Springer Science + Business Media.
  • Lui, R., Brown, A., Wu, B., Lin, M., Thompson, J., Braet, F., Dyer, W., Lattimore, J., Macdonald, P., Adelstein, S., Dos Remedios, C. (2008). Use of Antibody Microarrays in the Analysis of Inflammation, Autoimmunity, Viral Infection, and Cancer Metastases. In J. E. Van Eyk and M. J. Dunn (Eds.), Clinical Proteomics: From Diagnosis to Therapy, (pp. 571-592). Weinheim: Wiley - V C H Verlag GmbH & Co. KGaA.

2007

  • Dos Remedios, C., Chhabra, D. (2007). Foreword. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. v-vii). New York: Springer Science + Business Media.
  • Dos Remedios, C. (2007). New and Notable: The regulation of muscle contraction: As in life, it keeps getting more complex. Biophysical Journal, 93(12), 4097-8. [More Information]
  • Gan, B., Nosworthy, N., McKenzie, D., Dos Remedios, C., Bilek, M. (2007). Plasma immersion ion implantation treatment of polyethylene for enhanced binding of active horseradish peroxidase. Journal of Biomedical Materials Research. Part A, 85A(3), 605-610. [More Information]
  • Ho, J., Nosworthy, N., Bilek, M., Gan, B., McKenzie, D., Chu, P., Dos Remedios, C. (2007). Plasma-treated polyethylene surfaces for improved binding of active protein. Plasma Processes and Polymers, 4(5), 583-590. [More Information]
  • Zhang, L., Merkus, D., Hamdani, N., Lamers, J., Paulus, W., Dos Remedios, C., Duncker, D., Stienen, G., van der Velden, J. (2007). Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies. Proteomics - Clinical Applications, 1, 1285-1290.
  • Nicolau, D., Solana, G., Kekic, M., Fulga, F., Mahanivong, C., Wright, S., Dos Remedios, C. (2007). Surface Hydrophobicity modulates the operation of actomyosin-based dynamic nanodevices. Langmuir, 23(21), 10846-10854. [More Information]

2006

  • Dos Remedios, C., McKenzie, D., Boswell, R., Lui, R., Bilek, M., Charles, C., Ramdutt, D. (2006). Development of the nanotiter plate for use in antibody and cell array technologies. SPIE - Biomedical Applications of Micro- and Nano-engineering, Australia: SPIE Proceedings.
  • Narolska, N., Piroddi, N., Belus, A., Boontje, N., Scellini, B., Deppermann, S., Zaremba, R., Musters, R., Dos Remedios, C., Jaquet, K., Murphy, A., et al (2006). Impaired Diastolic Function After Exchange of Endogenous Troponin I with C-Terminal Truncated Troponin I in Human Cardiac Muscle. Circulation Research, 99(9), 1012-1020. [More Information]
  • Gorbatyuk, V., Nosworthy, N., Robson, S., Bains, N., Maciejewski, M., Dos Remedios, C., King, G. (2006). Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction. Molecular Cell, 24(4), 511-522.
  • Steel, B., McKenzie, D., Bilek, M., Nosworthy, N., Dos Remedios, C. (2006). Nanosecond responses of proteins to ultra-high temperature pulses. Biophysical Journal, 91(6), L66-L68. [More Information]
  • Dos Remedios, C., Qin, Z., Shi, Y. (2006). The Amazing Human Body:the anatomical display of real human bodies. Australia: Redtail.
  • Dedova, I., Nikolaeva, O., Safer, D., De La Cruz, E., Dos Remedios, C. (2006). Thymosin beta4 induces a conformational change in actin monomers. Biophysical Journal, 90(3), 985-992. [More Information]

2005

  • Martinez-Neira, R., Kekic, M., Nicolau, D., Dos Remedios, C. (2005). A novel biosensor for mercuric ions based on motor proteins. Biosensors and Bioelectronics, 20(7), 1428-1432. [More Information]
  • Kekic, M., Dos Remedios, C., Martinez, R., Nicolau, D. (2005). An acto/myosin in vitro motility assay as a motion based sensor. Biophysical Society 49th Annual Meeting, Bethesda, MD: Biophysical Society.
  • Lui, R., Tsubakihara, M., Macdonald, P., Hayward, C., Dos Remedios, C. (2005). Analysing inflammation in heart failure using microarray platforms. 27th Annual Meeting of the American Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press Elsevier.
  • Chhabra, D., Dos Remedios, C. (2005). Cofilin, actin and their complex observed in vivo using fluorescence resonance energy transfer. Biophysical Journal, 89(3), 1902-1908. [More Information]
  • Thordarson, P., Bilek, M., McKenzie, D., Nosworthy, N., Davies, K., Morrow, R., Gan, B., Dos Remedios, C. (2005). Functional Attachment of Horse Radish Peroxidase to Plasma Treated Surfaces. Smart Materials III, : SPIE Press.
  • Chhabra, D., Dos Remedios, C. (2005). Intracellular fluorescence resonance energy transfer. Biophysical Journal, 89, 1902-1908.
  • Jiang, L., Bardini, M., Keogh, A., Dos Remedios, C., Burnstock, G. (2005). P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium. International Journal of Cardiology, 98(2), 291-297. [More Information]
  • Chhabra, D., Nosworthy, N., Dos Remedios, C. (2005). The N-terminal fragment of gelsolin inhibits the interaction of DNase I with isolated actin, but not with the cofilin-actin complex. Proteomics, 5(12), 3131-3136. [More Information]

2004

  • Steel, B., Bilek, M., Dos Remedios, C., McKenzie, D. (2004). Apparatus For Exposing Cell Membranes To Rapid Temperature Transients. European Biophysics Journal, 33(2), 117-120. [More Information]
  • Tsubakihara, M., Williams, N., Keogh, A., Dos Remedios, C. (2004). Comparison Of Gene Expression Between Left Atria And Left Ventricles From Non-Diseased Humans. Proteomics, 4(1), 261-270.
  • Dedova, I., Dos Remedios, C. (2004). Conformational changes of actin induced by strong or weak myosin subfragment-1 binding. Tsitologiya, 46(8), 719-734. [More Information]
  • Borovikov, Y., Dedova, I., Dos Remedios, C., Vikhoreva, N., Vikhorev, P., Avrova, S., Hazlett, T., Van Der Meer, B. (2004). Fluorescence Depolarization Of Actin Filaments In Reconstructed Myofibers: The Effect Of S1 Or pPDM-S1 On Movements Of Distinct Areas Of Actin. Biophysical Journal, 86(5), 3020-3029.
  • Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]
  • Dedova, I., Nikolaeva, O., Mikhailova, V., Dos Remedios, C., Levitsky, D. (2004). Two Opposite Effects Of Cofilin On The Thermal Unfolding Of F-Actin: A Differential Scanning Calorimetric Study. Biophysical Chemistry, 110(1-2), 119-128. [More Information]

2003

  • Dos Remedios, C., Chhabra, D., Kekic, M., Dedova, I., Tsubakihara, M., Berry, A., Nosworthy, N. (2003). Actin binding proteins: Regulation of cytoskeletal microfilaments. Physiological Reviews, 83, 433-473.
  • Ng, D., Court, N., Dos Remedios, C., Bogoyevitch, M. (2003). Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts. Cardiovascular Research, 57, 333-346.
  • Dunn, T., Heller, C., McCarthy, S., Dos Remedios, C. (2003). Anatomical study of the "Trochanteric Bursa". Clinical Anatomy, 16(3), 233-240. [More Information]
  • Steel, B., Bilek, M., Dos Remedios, C., McKenzie, D. (2003). Apparatus for exposing cell membranes to rapid temperature transients. European Biophysics Journal, 11, 117-120.
  • Jiang, L., Huang, Y., Hunyor, S., Dos Remedios, C. (2003). Cardiomyocyte apoptosis is associated with increased wall stress in chronic failing left ventricle. European Heart Journal, 24, 742-751.
  • Dos Remedios, C., Liew, C., Allen, P., Winslow, R., Van Eyk, J., Dunn, M. (2003). Genomics, proteomics and bioinformatics of human heart failure. Journal Of Muscle Research And Cell Motility, 24(4-6), 251-260.

2002

  • Steel, B., Bilek, M., McKenzie, D., Dos Remedios, C. (2002). A technique for microsecond heating & cooling of a thin (submicron) biological sample. European Biophysics Journal, 31(5), 378-382. [More Information]
  • Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149.
  • Court, N., Dos Remedios, C., Cordell, J., Bogoyevitch, M. (2002). Cardiac expression & subcellular localization of the p38 Mitogen-activated protein kinase member, stress-activated protein kinases-3 (SAPK3). Journal of Molecular and Cellular Cardiology, 34(4), 413-426.
  • Dedova, I., Dedov, V., Nosworthy, N., Hambly, B., Dos Remedios, C. (2002). Cofilin and DNase 1 affect the conformation of the small domain of actin. Biophysical Journal, 82, 3134-3143.
  • Heller, C., Marucci, D., Dunn, T., Barr, E., Houang, M., Dos Remedios, C. (2002). Inguinal canal 'Lipoma'. Clinical Anatomy, , 280-285. [More Information]
  • Bains, N., Gorbatyuk, V., Nosworthy, N., Robson, S., Maciejewski, M., Dos Remedios, C., King, G. (2002). Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin. Journal of Biomolecular NMR, 22(2), 193-194.
  • Mahanivong, C., Wright, J., Kekic, M., Pham, D., Dos Remedios, C., Nicolau, D. (2002). Manipulation of the motility of protein molecular motors on microfabricated substrates. Biomedical Microdevices, 4(2), 111-116.
  • Dos Remedios, C., Thomas, D. (2002). Molecular Interactions of Actin; Actin-Myosin Interaction & Actin-Based Regulation. United States: Springer.
  • Chhabra, D., Bao, B., Dos Remedios, C. (2002). The distribution of cofilin and DNase I in vivo. Cell Research, 12(3-4), 207-214.

2001

  • Dos Remedios, C., Thomas, D. (2001). An overview of actin structure and actin-binding proteins. In Cristobal G. Dos Remedios & David D. Thomas (Eds.), Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins, (pp. 1-7). Germany: Springer.
  • Dos Remedios, C., Moens,, P. (2001). Analysis of models of F-Actin using fluorescence resonance energy transfer spectroscopy. In Cristobal G. Dos Remedios & David D. Thomas (Eds.), Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins, (pp. 59-76). Germany: Springer.
  • Heinke, M., Yao, M., Chang, D., Einstein, R., Dos Remedios, C. (2001). Apoptosis of ventricular and atrial myocytes from pacing-induced canine heart failure. Cardiovascular Research, 49 (1), 127-134.
  • Jiang, L., Tsubakihara, M., Heinke, M., Phillips, W., Dos Remedios, C., Nosworthy, N., Yao, M. (2001). Heart failure and apoptosis: Electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics. Proteomics, 1 (12), 1481-1488.
  • Belov, L., de la Vega, O., Dos Remedios, C., Christopherson, R., Mulligan,, S. (2001). Immunophenotyping of leukemias using a cluster of differentiation antibody microarray. Cancer Research, 61(11), 4483-4489.
  • Berry, D., Dos Remedios, C., Keogh, A. (2001). Nuclear membrane proteins in failing human dilated cardiomyopathy. Proteomics, 1 (12), 1507-1512.
  • Kekic, M., Nosworthy, N., Dedova, I., Collyer, C., Dos Remedios, C. (2001). Regulation of the cytoskeleton assembly: a role for a ternary complex of actin with two actin-binding proteins. In Cristobal G. Dos Remedios & David D. Thomas (Eds.), Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins, (pp. 165-177). Germany: Springer.
  • Nosworthy, N., Kekic, M., Dos Remedios, C. (2001). The affinity of chick cofilin for actin increases when actin is complexed with DNase 1: Formation of a cofilin-actin-DNase 1 ternary complex. Proteomics, 1 (12), 1513-1518.

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