Dr David Pattison
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Research Fellow |
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Research interests
There is compelling evidence that myeloperoxidase, and the oxidants that it produces, play an important role in the progression of atherosclerosis and other diseases, but there is a lack of knowledge of the key processes involved. My research aims to increase understanding at the molecular level, of the potential in vivo reactions of the primary myeloperoxidase-derived oxidants, hypohalous acids (HOCl, HOBr and HOSCN), and their reactive products (e.g. halogenated amines (halamines)). To achieve this I am undertaking thorough kinetic and product studies to determine the major targets of these oxidants with amino acids, peptides, proteins, lipids and antioxidants, and assessing the quantitative significance of these reactions via the characterisation and quantification of novel products.