Dr Devanshi Seth

Principal Scientist
Group Head (alcoholic liver disease)
NIH Project Leader (GenomALC)
Clinical Senior Lecturer

Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 95157201
Fax +61 2 9515 5779

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Biographical details

Dr Seth, BSc (Hons), MSc (Agriculture), MPH, PhD (Genetics), is a Principal Scientist and Clinical Senior Lecturer at the (i) Drug Health Services (DHS), (ii) Centenary Institute (CI) at RPAH; and at the University of Sydney (USYD), Clinical and Addiction Medicine. Dr Devanshi Seth has more than 25 years of training and experience as Molecular Biologist in Biotechnology industry and more recently in Public Health, with 10 years of contribution towards alcohol research. Dr Seth has several publications in peer reviewed high impact journals in this area. Her work is recognised internationally through invitations to chair and present at international meetings and has generated several national and international collaborations. She also has long term collaboration with Prof Geoff McCaughan, Director AW Morrow Gastroenterology & Liver Clinic, RPAH and Prof Paul Haber, Medical Director, DHS, Sydney South West Area Health Service (SSWAHS).

Several current research interests in Dr Seth's group encompass from basic understanding of molecular pathogenesis to genetic and other risk factors for ALD as well as treatment options for patients with ALD. 1. Molecular pathogenesis and identification of biomarkers (see Honours project on SPP1) 2. Identification of genetic risk factors in a genome wide association study (GWAS) for ALD, as part of the multi-centre international GenomALC Consortium (see Honours project on ALC-GWAs) 3. To identify co-morbidities (e.g. mental health, viral infection) associated with alcoholic liver cirrhosis. 4. To establish a clinic that includes experts in hepatology, counseling and addication medicine as a comprehensive ¿consultation liaison model of care¿ for treatment of patients with alcoholic liver disease. 5. To evaluate bioavailability of Naltraxone implants in an animal model for treatment of alcoholism (industry funding in collaboration with Prof Haber). Dr Seth is the lead PI on several grants including NIH/NIAAA, Department of NSW Health, Alcohol Health & Research Grant Scheme (AHRGS), Alcohol Education & Rehabilitation Foundation (AERF), Analytica Ltd, that support the above research projects.

Research interests

Dr Devanshi Seth has an international profile in alcohol research: to understand the molecular pathogenesis, genetics and associated risk factors, prevention and treatment of alcoholic liver disease (ALD) through novel therapeutic agents.

Areas of research: Clinical; in vitro and in vivo models of alcohol; Chronic Alcohol; Alcohol related tissue injury; Alcoholism/Addiction; Liver; Cirrhosis/Fibrosis Opportunities for Honours and PhD: All current research listed above have opportunity for students as honours and/or PhD projects.

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

International links

Australia

(Queensland Institute of Medical Research, Brisbane) John B Whitfield, BSc, MSC, PhD, MRCPath, FRCPath is the Director a Senior Principal Research Fellow at the Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Drs Whitfield and Seth have had ~8 years of collaboration and held joint grants during this period.

France

(University Paris XII, France) Bertrand Nalpas, M.D, PhD, is Director of research at the University Paris VII, France. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

Germany

(Salem Medical Center, Heidelberg Centre of Alcohol Research Liver Disease and Nutrition, University of Heidelberg) Helmut Karl Seitz, M.D., PhD, AGAF is Professor, Medical Director, Department of Medicine, Salem Medical Center, Heidelberg; Head, Centre of Alcohol Research Liver Disease and Nutrition. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

Switzerland

(University of Bern, Switzerland) Felix Stickel, M.D. is an Associate Professor and GI specialist at the University of Heidelberg and University of Eirlangen, Germany and Head, Dept. of Visceral Surgery and Medicine, University of Bern. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

United Kingdom

(University of Newcastle, UK) DAY, Christopher Paul, MD, MRCP, PhD, FRCP is Pro Vice Chancellor of Medical Sciences & Professor of Liver Medicine at the University of Newcastle, UK. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Prof Day and Dr Seth have also published together recently in Hepatology.

United States

(Indiana University, Bloomington, IN) Lawrence Lumeng, M.D. is a Professor, Physician/Scientist at the Indiana University, Bloomington, IN. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

United States

(University of California, LA Indiana school of Medicine, Indianpolis) Prof Tatiana Foroud, B.s, M.S, PhD is Professor of Medical & Molecular Genetics. She is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Dr Seth and Prof Foroud have jointly organised symposium on GWAS at the ISBRA 2008 meeting.

United States

(University of California-Irvine VA Medical Center, Long Beach CA) Timothy R, MORGAN, MD is Professor of Medicine, University of California, Irvine and Chief, Hepatology at the VA Medical Centre. He is the lead US Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

Selected grants

2014

  • Protease therapies for diabetes-associated liver disease; Gorrell M, Keane F, Cook A, Shackel N, Seth D, Chen J, Jolly C, Hare N, McCaughan G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2011

  • Genetic risk factors for alcoholic cirrhosis - genome wide case control study; Seth D, Haber P, Nalpas B, Stickel F, Day C, Lumeng L, Morgan T, Whitfield J; National Institutes of Health (USA)/Research Support.
  • THE ROLE OF OSTEOPONTIN (Opn) IN ALCOHOLIC LIVER INJURY; Seth D; DVC Research/Bridging Support Grant.

2010

  • Identification of co-morbidities associated with alcoholic liver disease; Seth D, Proude E; Alcohol Education and Rehabilitation Foundation/Research Grant.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

Selected publications

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Book Chapters

  • Lakshman, M., Garige, M., Gong, M., Leckey, L., Varatharajalu, R., Redman, R., Seth, D., Haber, P., Hirsch, K., Amdur, R., et al (2013). CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism. In Aparajita Dey (Eds.), Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism, (pp. 199-233). Dordrecht: Springer Science + Business Media.
  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers.

Journals

  • Keane, F., Tsun-Wen, Y., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
  • Phillips, R., Helbig, K., Van der Hoek, K., Seth, D., Beard, M. (2012). Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World Journal of Gastroenterology, 18(26), 3389-3399. [More Information]
  • Seth, D., Haber, P., Syn, W., Diehl, A., Day, C. (2011). Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances. Journal of Gastroenterology and Hepatology, 26(7), 1089-1105. [More Information]
  • Seth, D., El-Guindy, N., Apte, M., Mari, M., Dooley, S., Neuman, M., Haber, P., Kundu, G., Darwanto, A., De Villiers, W., et al (2010). Alcohol, Signaling, and ECM Turnover. Alcoholism: Clinical and Experimental Research, 34(1), 1-15. [More Information]
  • Seth, D., Daly, A., Haber, P., Day, C. (2010). Patatin-like phospholipase domain containing 3: a case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease. Hepatology, 51(4), 1463-1465. [More Information]
  • Gong, M., Castillo, L., Redman, R., Garige, M., Hirsch, K., Azuine, M., Amdur, R., Seth, D., Haber, P., Lakshmanan, M. (2008). Down-regulation of liver Galβ1, 4GlcNAc α2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Metabolism: clinical and experimental, 57(12), 1663-1668. [More Information]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive diseases and sciences, 53(6), 1468-1487. [More Information]
  • Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
  • Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
  • Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]
  • Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. The American Journal of Pathology: cellular and molecular biology of disease, 163(6), 2303-2317.
  • Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344.
  • Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66.

Conferences

  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.

2014

  • Keane, F., Tsun-Wen, Y., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]

2013

  • Lakshman, M., Garige, M., Gong, M., Leckey, L., Varatharajalu, R., Redman, R., Seth, D., Haber, P., Hirsch, K., Amdur, R., et al (2013). CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism. In Aparajita Dey (Eds.), Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism, (pp. 199-233). Dordrecht: Springer Science + Business Media.

2012

  • Phillips, R., Helbig, K., Van der Hoek, K., Seth, D., Beard, M. (2012). Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World Journal of Gastroenterology, 18(26), 3389-3399. [More Information]

2011

  • Seth, D., Haber, P., Syn, W., Diehl, A., Day, C. (2011). Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances. Journal of Gastroenterology and Hepatology, 26(7), 1089-1105. [More Information]

2010

  • Seth, D., El-Guindy, N., Apte, M., Mari, M., Dooley, S., Neuman, M., Haber, P., Kundu, G., Darwanto, A., De Villiers, W., et al (2010). Alcohol, Signaling, and ECM Turnover. Alcoholism: Clinical and Experimental Research, 34(1), 1-15. [More Information]
  • Seth, D., Daly, A., Haber, P., Day, C. (2010). Patatin-like phospholipase domain containing 3: a case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease. Hepatology, 51(4), 1463-1465. [More Information]

2008

  • Gong, M., Castillo, L., Redman, R., Garige, M., Hirsch, K., Azuine, M., Amdur, R., Seth, D., Haber, P., Lakshmanan, M. (2008). Down-regulation of liver Galβ1, 4GlcNAc α2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Metabolism: clinical and experimental, 57(12), 1663-1668. [More Information]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive diseases and sciences, 53(6), 1468-1487. [More Information]

2007

  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers.

2006

  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
  • Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
  • Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]

2003

  • Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. The American Journal of Pathology: cellular and molecular biology of disease, 163(6), 2303-2317.
  • Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344.
  • Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66.

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