Dr Devanshi Seth

Principal Scientist
Group Head (alcoholic liver disease)
NIH Project Leader (GenomALC)
Clinical Senior Lecturer

Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 95157201
Fax +61 2 9515 5779

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Biographical details

Dr Seth, BSc (Hons), MSc (Agriculture), MPH, PhD (Genetics), is a Principal Scientist and Clinical Senior Lecturer at the (i) Drug Health Services (DHS), (ii) Centenary Institute (CI) at RPAH; and at the University of Sydney (USYD), Clinical and Addiction Medicine. Dr Devanshi Seth has more than 25 years of training and experience as Molecular Biologist in Biotechnology industry and more recently in Public Health, with more than 10 years contribution towards alcohol research. Dr Seth has several publications in peer reviewed high impact journals in this area. Her work is recognised internationally through invitations to chair and present at international meetings and has generated several national and international collaborations. She also has long term collaboration with Prof Geoff McCaughan, Director AW Morrow Gastroenterology & Liver Clinic, RPAH and Prof Paul Haber, Medical Director, DHS, Sydney South West Area Health Service (SSWAHS).

Several current research interests in Dr Seth's group encompass from basic understanding of molecular pathogenesis to genetic and other risk factors for ALD as well as treatment options for patients with ALD. 1. Molecular pathogenesis and identification of biomarkers (see Honours and PhD projects) 2. Identification of genetic risk factors in thousands of drinkers through a genome wide association study (GWAS) for to identify risk alleles associated with alcoholic cirrhosis, as part of the multi-centre international GenomALC Consortium (see Honours project on ALC-GWAs) 3.To investigate the role ofbone marrow-derived endothelial progenitor cells in liver injury, another interantional collaborative projectfunded byAustralia India Strategic Research Fund (AISRF).Dr Seth is the lead PI on several grants including NIH/NIAAA, AISRF, Department of NSW Health, Alcohol Health & Research Grant Scheme (AHRGS), Alcohol Education & Rehabilitation Foundation (AERF), Analytica Ltd, amounting to approximately $4 million funds to support the above research projects.

Dr Seth is has several professional memberships for alcohol and liver related organsiations, is a reviewer on international grants and journals. She is an Executivemember of the University of Sydney Human Research Ethics Committee (HREC Exec)and Chairs the Women in Science (WiS) group at the Centenary Institute.

Research interests

Dr Devanshi Seth has an international profile in alcohol research: to understand the molecular pathogenesis, genetics and associated risk factors, prevention and treatment of alcoholic liver disease (ALD) through novel therapeutic agents.

Areas of research: Clinical; in vitro and in vivo models of alcohol; Chronic Alcohol; Alcohol related tissue injury; Alcoholism/Addiction; Liver; Cirrhosis/Fibrosis Opportunities for Honours and PhD: All current research listed above have opportunity for students as honours and/or PhD projects.

Teaching and supervision

Developed a modular eLearning course "To develop a cross-platform visual module to increase awareness of the effects of chronic alcohol drinking on the liver" under the "Integrated learning space for engaged enquiry program" at the University of Sydney.

This course with short quiz is available online for USYD students.

Interested in research based teaching for post-graduate Honours and PhD students in my area of expertise.

Current projects

Dr Seth champions the first and largest study of its kind on the genetics of ALD funded by the NIH/NIAAA under the multinational GenomALC Consortium (www.genomalc.org). Recruitment of thousands of drinkers at multiple sites across Australia, USA, UK, Germany, France and Switzerland is ongoing. The DNA from 5000 participants will be used for genotyping single nucleotide polymorphisms (SNPs) in a genome-wide association (GWA) approach. Under her direction the study has built a valuable and unique resource of over 2600 patients’ drinking history and other well characterised phenotype data, as well as linked clinical specimens for the GenomALC biorepository. This study has been successful in producing 5 publications, 10 presentations, 2 symposia and several media releases.

Dr Seth leads another concurrent international Australia India Stratgic Research Fund (AISRF) project investigating the angiogenic and immunomodulatory role of bone-marrow (BM) derived endothelial progenitor cells (EPCs) in liver regeneration during alcohol induced injury. This collaboration is between Prof Shiv Sarin, Director of India’s largest and most prestigiousInstitute of Liver and Biliary Science (ILBS), and one of three WHO viral hepatitis centres in the world and Dr Nirupama Trhanpati, Additional Professor at the Clinical and Cellular Transplant Immunology & Department of Research, ILBS. Other internal collaborators on this study are Profs G McCaughan, J Gamble and P Haber. The main study aim is to investigate the role of BM derived EPCs and to determine whether and how these cells participate in liver angiogenesis and immunomodulation, andpromote subsequent liver regenerationin animal models of acute and chronic alcohol consumption. The study is ongoing and is likely to provide important insights into different mechanisms of liver regeneration by these BM-cells in chronic liver disease, where regeneration by the resident hepatocytes is severely inhibited. Understanding the mechanisms of EPC action in liver disease has the potential for identification of molecules/pathways as novel therapeutic and diagnostic targets. For this AISRF project, my group has established protocols to identify the rare population of endothelial progenitor cells in mice using 8-colour flow cytometric analysis in in vivo mouse models of acute alcohol-induced liver injury.

Both projects have opportunities for Honours and PhD.

Awards and honours

Received several awards from professional alcohol/liver societies, such as the NIH, NIAAA, European Association for Study of Liver (EASL), International Society for Biomedical Research on Alcohol (ISBRA), Research Society on Alcoholism (RSA), Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ALPD) for international travel and organizing symposia/satellite meetings (2006-2014), and as visiting scientist from the Australia Academy of Science (AAS) in 2009. Chair, Gender Equity Program (GEP)

Recently honored as one of three outstanding women for their leadership and contribution to their respective research field by Prof Belinda Hutchinson (Chancellor, University of Sydney), Aug 2015

Received travel grant from Centenary Institute to attend Women in Health Sciences workshopconducted by NHMRC, Melbourne, 25th May 2015 and Franklin Women grant writing workshop, Nov 2015.

Under her leadership, the Gender Equity Program (GEP) received Team Excellence award for Centenary Institute and a $500 cheque.

Images of figures selected as front cover for Seth et al., J Hepatol 2006; J Hepatol 2008

In the media

2015

§ Chanel 10 News coverage ‘Liver disease: a hidden epidemic’ 12 Nov 2015. https://www.facebook.com/devanshi.seth.12/posts/10204065140227286?notif_t=like

§ GenomALC GWAS study paper selected by the journal editors for ‘Public Interest Highlights’ and published by-

§ EurekAlert (http://www.eurekalert.org/pub_releases/2015-04/ace-pap040815.php)

§ Centenary Institute (http://www.centenary.org.au/p/)

§ 23rd July, 2015: Prime time Chanel 7 news

§ Other science media (http://www.lifescientist.com.au/content/molecular-biology/news/is-alcoholic-liver-disease-in-your-genes--786684075; http://medicalxpress.com/news/2015-04-paternal-alcohol-problems-death-liver.html)

§ Sydney research (SLHD) (http://sydneyresearchhub.com.au/)

2012

v Live TV and radio interviews Sky TV, ABC Queensland, 2UE, 2GB

§ Newspaper coverage on Sydney Morning Herald, Inner West Courier

o http://www.smh.com.au/national/health/search-for-genetic-clues-to-cruel-lottery-of-drinkinduced-cirrhosis-20120311-1usnt.html

o http://www.ulladullatimes.com.au/news/national/national/general/search-for-genetic-clues-to-cruel-lottery-of-drinkinduced-cirrhosis/2484523.aspx

o http://news.ninemsn.com.au/health/8433740/us-govt-investing-in-sydney-liver-study

§ Newsletters: RPAH, SLHD, Centenary Institute and University of Sydney http://sydney.edu.au/news/84.html?newsstoryid=8809.

Painting: especially watercolour. Have participated in several exhibitions in Perth, WA and Sydney. Won prizes-first, people choice, commended

Pottery: love to hand build. Exhibited in several exhibitions and won first prize and commended

Reading: Addicted to thrillers and mysteries but love reading scientists and artists biographies; collect books on multiple subjects-psychology, science, autobiographies

Music: Grew up with Indian Bollywood music so my being is immersed in that forever. Also love jazz, Caribbean music

Walking: to explore new places and think creatively

Cooking: and this is my passion. for me cooking is therapeutic-I love to cook fresh meals daily

Keywords

Genomics; Cell & Molecular Biology; Alcohol; Inflammation; Liver

Clinical Specialty

Gastroenterology and Hepatology

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

International links

Australia

(Queensland Institute of Medical Research, Brisbane) John B Whitfield, BSc, MSC, PhD, MRCPath, FRCPath is the Director a Senior Principal Research Fellow at the Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Drs Whitfield and Seth have had ~8 years of collaboration and held joint grants during this period.

France

(University Paris XII, France) Bertrand Nalpas, M.D, PhD, is Director of research at the University Paris VII, France. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

Germany

(Salem Medical Center, Heidelberg Centre of Alcohol Research Liver Disease and Nutrition, University of Heidelberg) Helmut Karl Seitz, M.D., PhD, AGAF is Professor, Medical Director, Department of Medicine, Salem Medical Center, Heidelberg; Head, Centre of Alcohol Research Liver Disease and Nutrition. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

India

(Clinical and Cellular Transplant Immunology & Department of Research, Institute of Liver and Biliary Sciences (ILBS). ) Dr Nirupama Trehanpati, Additional Professor and Dr Seth collaborate closely on a concurrent international AISRF project. The study is investigating the angiogenic and immunomodulatory role of bone-marrow (BM) derived endothelial progenitor cells (EPCs) in liver regeneration during alcohol induced injury. Drs Seth and Trehanpati lead the respective teams in Australia and India. They have visited each other's institutes and worked closely in developing this joint project. There has been substantial exchange of knowledge, technology and resources between the two teams during these visits

India

(Institute of Liver and Biliary Sciences, New Delhi, India) Prof Shiv Sarin, Director of the largest and most prestigious Institute of Liver and Biliary Science (ILBS), also the WHO viral hepatitis centre, is a principal investigator of the Indian team for the Australia India Strategic Research Fund collaborative project on "The immunomodulatory and angiogenic role of bone marrow-derived endothelial progenitor cells in chronic liver disease".

Switzerland

(University of Bern, Switzerland) Felix Stickel, M.D. is an Associate Professor and GI specialist at the University of Heidelberg and University of Eirlangen, Germany and Head, Dept. of Visceral Surgery and Medicine, University of Bern. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

United Kingdom

(University of Newcastle, UK) DAY, Christopher Paul, MD, MRCP, PhD, FRCP is Pro Vice Chancellor of Medical Sciences & Professor of Liver Medicine at the University of Newcastle, UK. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Prof Day and Dr Seth have also published together recently in Hepatology.

United States

(Indiana University, Bloomington, IN) Lawrence Lumeng, M.D. is a Professor, Physician/Scientist at the Indiana University, Bloomington, IN. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

United States

(University of California, LA Indiana school of Medicine, Indianpolis) Prof Tatiana Foroud, B.s, M.S, PhD is Professor of Medical & Molecular Genetics. She is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Dr Seth and Prof Foroud have jointly organised symposium on GWAS at the ISBRA 2008 meeting.

United States

(University of California-Irvine VA Medical Center, Long Beach CA) Timothy R, MORGAN, MD is Professor of Medicine, University of California, Irvine and Chief, Hepatology at the VA Medical Centre. He is the lead US Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

Selected grants

2015

  • Novel therapy approaches for diabetes and its liver and heart complications; Gorrell M, Keane F, Tu T, Shackel N, Bowen D, Bertolino P, Seth D, Chen J, Cook A, Liu R, Zheng X, Gamble J, McCaughan G; Rebecca L Cooper Medical Research Foundation/Research Support.

2014

  • The immunomodulatory and angiogenic role of bone marrow-derived endothelial progenitor cells in chronic liver disease; Seth D; Australia India Strategic Research Fund/Research Support.
  • The immunomodulatory and angiogenic role of bone marrow-derived endothelial progenitor cells in chronic liver disease; Seth D, Haber P, McCaughan G, Gamble J, Duly A, Sarin S, Kaur S, Trehanpati N; Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education (Fed)/Australia-India Strategic Research Fund (AISRF).
  • Protease therapies for diabetes-associated liver disease; Gorrell M, Keane F, Cook A, Shackel N, Seth D, Chen J, Jolly C, Hare N, McCaughan G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Early identification of Alcoholic Liver Disease: investigating changes through genomics, epigenomics and immunoregulation studies; Seth D; Anonymous Philanthropic/Research Support.

2011

  • Genetic risk factors for alcoholic cirrhosis - genome wide case control study; Seth D, Haber P, Nalpas B, Stickel F, Day C, Lumeng L, Morgan T, Whitfield J; National Institutes of Health (USA)/Research Support.
  • THE ROLE OF OSTEOPONTIN (Opn) IN ALCOHOLIC LIVER INJURY; Seth D; DVC Research/Bridging Support Grant.
  • Genetics and molecular pathogenesis of ALD; Seth D; Anonymous Philanthropic/Research Support.

2010

  • Identification of co-morbidities associated with alcoholic liver disease; Seth D, Proude E; Alcohol Education and Rehabilitation Foundation/Research Grant.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Paull, P., Haber, P., Seth, D. (2015). Drug testing and biomarkers of alcohol consumption. In Paul Haber, Carolyn Day, Michael Farrell (Eds.), Addiction Medicine: Principles and Practice, (pp. 143-162). Melbourne: IP Communications.
  • Lakshman, M., Garige, M., Gong, M., Leckey, L., Varatharajalu, R., Redman, R., Seth, D., Haber, P., Hirsch, K., Amdur, R., et al (2013). CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism. In Aparajita Dey (Eds.), Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism, (pp. 199-233). Dordrecht: Springer Science+Business Media.
  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers.

Journals

  • Whitfield, J., Rahman, K., Haber, P., Day, C., Masson, S., Daly, A., Cordell, H., Mueller, S., Seitz, H., Liangpunsakul, S., Seth, D., et al (2015). Brief report: Genetics of alcoholic Cirrhosis-GenomALC multinational study. Alcoholism: Clinical and Experimental Research, 39(5), 836-842. [More Information]
  • Meikle, P., Mundra, P., Wong, G., Rahman, K., Huynh, K., Barlow, C., Duly, A., Haber, P., Whitfield, J., Seth, D. (2015). Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. PloS One, 10(6), 1-13. [More Information]
  • Duly, A., Alani, B., Huang, E., Yee, C., Haber, P., McLennan, S., Seth, D. (2015). Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity. Nutrition and Diabetes, 5, 1-9.
  • Salameh, H., Raff, E., Erwin, A., Seth, D., Nischalke, H., Falleti, E., Burza, M., Leathert, J., Romeo, S., Molinaro, A., et al (2015). PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease. American Journal of Gastroenterology, 110(6), 846-856. [More Information]
  • Neuman, M., French, S., French, B., Seitz, H., Cohen, L., Osna, N., Kharbanda, K., Seth, D., Bautista, A., Thompson, K., et al (2014). Alcoholic and non-alcoholic steatohepatitis. Experimental and Molecular Pathology, 97(3), 492-510. [More Information]
  • Seth, D., Duly, A., Kuo, P., McCaughan, G., Haber, P. (2014). Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation. World Journal of Gastroenterology, 20(36), 13088-13104. [More Information]
  • Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
  • Phillips, R., Helbig, K., Van der Hoek, K., Seth, D., Beard, M. (2012). Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World Journal of Gastroenterology, 18(26), 3389-3399. [More Information]
  • Seth, D., Haber, P., Syn, W., Diehl, A., Day, C. (2011). Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances. Journal of Gastroenterology and Hepatology, 26(7), 1089-1105. [More Information]
  • Seth, D., El-Guindy, N., Apte, M., Mari, M., Dooley, S., Neuman, M., Haber, P., Kundu, G., Darwanto, A., De Villiers, W., et al (2010). Alcohol, Signaling, and ECM Turnover. Alcoholism: Clinical and Experimental Research, 34(11), 1-15. [More Information]
  • Seth, D., Daly, A., Haber, P., Day, C. (2010). Patatin-like phospholipase domain containing 3: a case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease. Hepatology, 51(4), 1463-1465. [More Information]
  • Gong, M., Castillo, L., Redman, R., Garige, M., Hirsch, K., Azuine, M., Amdur, R., Seth, D., Haber, P., Lakshmanan, M. (2008). Down-regulation of liver Galβ1, 4GlcNAc α2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Metabolism: Clinical and Experimental, 57(12), 1663-1668. [More Information]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive Diseases and Sciences, 53(6), 1468-1487. [More Information]
  • Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
  • Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
  • Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]
  • Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. The American Journal of Pathology: cellular and molecular biology of disease, 163(6), 2303-2317.
  • Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344.
  • Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66.

Conferences

  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.

2015

  • Whitfield, J., Rahman, K., Haber, P., Day, C., Masson, S., Daly, A., Cordell, H., Mueller, S., Seitz, H., Liangpunsakul, S., Seth, D., et al (2015). Brief report: Genetics of alcoholic Cirrhosis-GenomALC multinational study. Alcoholism: Clinical and Experimental Research, 39(5), 836-842. [More Information]
  • Meikle, P., Mundra, P., Wong, G., Rahman, K., Huynh, K., Barlow, C., Duly, A., Haber, P., Whitfield, J., Seth, D. (2015). Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. PloS One, 10(6), 1-13. [More Information]
  • Paull, P., Haber, P., Seth, D. (2015). Drug testing and biomarkers of alcohol consumption. In Paul Haber, Carolyn Day, Michael Farrell (Eds.), Addiction Medicine: Principles and Practice, (pp. 143-162). Melbourne: IP Communications.
  • Duly, A., Alani, B., Huang, E., Yee, C., Haber, P., McLennan, S., Seth, D. (2015). Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity. Nutrition and Diabetes, 5, 1-9.
  • Salameh, H., Raff, E., Erwin, A., Seth, D., Nischalke, H., Falleti, E., Burza, M., Leathert, J., Romeo, S., Molinaro, A., et al (2015). PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease. American Journal of Gastroenterology, 110(6), 846-856. [More Information]

2014

  • Neuman, M., French, S., French, B., Seitz, H., Cohen, L., Osna, N., Kharbanda, K., Seth, D., Bautista, A., Thompson, K., et al (2014). Alcoholic and non-alcoholic steatohepatitis. Experimental and Molecular Pathology, 97(3), 492-510. [More Information]
  • Seth, D., Duly, A., Kuo, P., McCaughan, G., Haber, P. (2014). Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation. World Journal of Gastroenterology, 20(36), 13088-13104. [More Information]
  • Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]

2013

  • Lakshman, M., Garige, M., Gong, M., Leckey, L., Varatharajalu, R., Redman, R., Seth, D., Haber, P., Hirsch, K., Amdur, R., et al (2013). CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism. In Aparajita Dey (Eds.), Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism, (pp. 199-233). Dordrecht: Springer Science+Business Media.

2012

  • Phillips, R., Helbig, K., Van der Hoek, K., Seth, D., Beard, M. (2012). Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World Journal of Gastroenterology, 18(26), 3389-3399. [More Information]

2011

  • Seth, D., Haber, P., Syn, W., Diehl, A., Day, C. (2011). Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances. Journal of Gastroenterology and Hepatology, 26(7), 1089-1105. [More Information]

2010

  • Seth, D., El-Guindy, N., Apte, M., Mari, M., Dooley, S., Neuman, M., Haber, P., Kundu, G., Darwanto, A., De Villiers, W., et al (2010). Alcohol, Signaling, and ECM Turnover. Alcoholism: Clinical and Experimental Research, 34(11), 1-15. [More Information]
  • Seth, D., Daly, A., Haber, P., Day, C. (2010). Patatin-like phospholipase domain containing 3: a case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease. Hepatology, 51(4), 1463-1465. [More Information]

2008

  • Gong, M., Castillo, L., Redman, R., Garige, M., Hirsch, K., Azuine, M., Amdur, R., Seth, D., Haber, P., Lakshmanan, M. (2008). Down-regulation of liver Galβ1, 4GlcNAc α2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Metabolism: Clinical and Experimental, 57(12), 1663-1668. [More Information]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive Diseases and Sciences, 53(6), 1468-1487. [More Information]

2007

  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers.

2006

  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
  • Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
  • Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]

2003

  • Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. The American Journal of Pathology: cellular and molecular biology of disease, 163(6), 2303-2317.
  • Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344.
  • Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66.

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