Dr Devanshi Seth

Principal Scientist and Group Head (Alcoholic Liver Disease Research Program)
NIH Project Leader (GenomALC)
Clinical Associate Professor, Faculty of Medicine and Health, USYD
Centenary Institute of Cancer Medicine &
Cell Biology

Telephone 02 95656268
Fax +61 2 9515 5779

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Biographical details

Dr Devanshi Seth, PhD (Genetics) MSc (Agriculture), MPH, BSc (Hons)

Dr Devanshi Seth is a Principal Scientist at the (i) Drug Health Services (DHS), Royal Prince Alfred Hospital and (ii) The Centenary Institute (CI), and (iii) Clinical Associate Professor at the Faculty of Medicine and Health, The University of Sydney (USYD). Dr Seth has a wide spectrum of expertise in molecular/cellular biology, genetics, clinical, cancer research, industrial biotechnology and corporate management.

Dr Seth directs a unique Research Program in Australia addressing the gaps in understanding Alcohol-induced Liver Disease. She established this research program as a response to this often neglected but a significant and much needed area of human health. Now an internationally known leader in the alcohol/liver field, she leads the NIH/NIAAA-funded study on genetics of alcoholic liver cirrhosis (ALC) using GWAS, by establishing a multinational GenomALC Consortium. Under her leadership, GenomALC has established the world's largest database and bio-bank of thousands of chronic heavy drinkers.

Dr Seth was recently elected as Treasurer of the Research Society on Alcoholism (RSoA), a unique association in the world on alcohol research. She is also an Executive member of the University of Sydney Human Research Ethics Committee (HREC 1).

Dr Seth is an active promoter of women in science, Founder Chair of Gender Equity Program at Centenary and Peer Advisory Committee member of Franklin Women, a peek body promoting women in the health and medical research sector (www.franklinwomen.com.au).

Research interests

Her overall research program includes studies on genetics of alcoholic cirrhosis, molecular mechanisms underlying liver disease, identifying biomarkers for alcohol use and liver injury, transcriptomics, lipid and miRNA profiling. Her group showed the first evidence of heritability for alcoholic cirrhosis from father to son was highlighted by editors (ACER 2015) as of ‘high public interest’ and covered by media (EurekAlert! and others outlets internationally. Global lipid profiling identified novel lipid species that in a combined model of lipid+traditional markers increased AUC and accuracy for prediction of cirrohsis in drinkers. Her group discovered novel pathways in ALC, such as Osteopontin (OPN), now recognized as a prognostic biomarker for liver injury and cancer, and defined OPN mechanisms in alcohol- and alcohol+fat-induced inflammation and fibrogenesis in human, in vitro and in vivo models. Her group recently established direct metabolites of alcohol (PEth, EtG, EtS) at her centre as routine clinical tests to detect exposure, abstinence and under-reporting of alcohol use. She has 58 publications (6 in 2018) in high impact journals in this field (Gastroenterology, Hepatology, Journal of Hepatology, Am J Pathology, Alcoholism: Clin Exp Res), majority as first/senior author. She is on the editorial board of 2 international journals and reviewer on >20 journals, (inter)national granting bodies and supervises PhD, Medicine and Honours students.

The current research projects in her group include:

1. Molecular pathogenesis and identification of biomarkers (miRNA profiles, lipidomics, transcriptomics) in clinical specimens from drinkers, and in vivo animal models of alcohol and alcohol+high fat diet.

2. Identification of genetic risk factors in a genome wide association study (GWAS) for Alcoholic Liver Disease, as part of the multi-centre international GenomALC Consortium

3. Establishing biomarkers (PEth, EtG) as clinical tests for alcohol use in patients (supervising current PhD project)

5. Global profiling serum and urinary microRNAs as biomarkers for acute kidney injury in patients following pesticide (potassium permanganate, oxalic acid), snake venom and prescription drug (paracetamol) poisoning (supervising current PhD project)

Teaching and supervision

Interested in research based teaching for post-graduate Honours and PhD students in my area of expertise. Currently supervising two PhD students, and one Medicine student.

Developed a modular eLearning course "To develop a cross-platform visual module to increase awareness of the effects of chronic alcohol drinking on the liver" under the "Integrated learning space for engaged enquiry program" at the University of Sydney.

This course with short quiz is available online for USYD students.

Current research students

Project title Research student
Investigating the role of MicroRNA in early detection of hepatotoxicity and nephrotoxicity following-poisoning Fathima Shihana HANIFFA SALAHUDEEN

Current projects

Dr Seth champions the first and largest study of its kind on the genetics of ALD funded by the NIH/NIAAA under the multinational GenomALC Consortium (www.genomalc.org). Recruitment of thousands of drinkers at multiple sites across Australia, USA, UK, Germany, France and Switzerland is ongoing. The DNA from ~6700 participants weree used for genotyping single nucleotide polymorphisms (SNPs) in a genome-wide association (GWA) approach. Under her direction the study has built a valuable and unique resource of over 2000 prospective patients’ drinking history and other well characterised phenotype data, as well as linked clinical specimens for the GenomALC biorepository. This study has been successful in producing 5 publications, 10 presentations, 2 symposia and several media releases.

This project has several spin off opportunities for PhD projects (DNA methylation, miRNA profiling, functional studies on identified SNPs).

Dr Seth led another concurrent international Australia India Stratgic Research Fund (AISRF, 2013-2016) project investigating the angiogenic and immunomodulatory role of bone-marrow (BM) derived endothelial progenitor cells (EPCs) in liver regeneration during alcohol induced injury. This collaboration was between Prof Shiv Sarin, Director of India’s largest and most prestigiousInstitute of Liver and Biliary Science (ILBS), and one of three WHO viral hepatitis centres in the world and Dr Nirupama Trhanpati, Additional Professor at the Clinical and Cellular Transplant Immunology & Department of Research, ILBS. Other internal collaborators on this study are Profs G McCaughan, J Gamble and P Haber. The main study aim is to investigate the role of BM derived EPCs and to determine whether and how these cells participate in liver angiogenesis and immunomodulation, andpromote subsequent liver regenerationin animal models of acute and chronic alcohol consumption. Understanding the mechanisms of liver regeneration by these BM-cells in chronic liver disease, where regeneration by the resident hepatocytes is severely inhibited. EPC action in liver disease has the potential for identification of molecules/pathways as novel therapeutic and diagnostic targets. For this AISRF project, my group has reported the first extensive characterization of circulating human EPCs using mass cytometery (CyTOF). Three distinct EPC subtypes were identified in alcoholic liver cirrhosis (ALC) patients. CD45hi EPCs with enhanced functions, inflammatory cytokines and angiogenic mediators significantly increased in ALC patients suggesting an inflammatory role for these cells in ALC pathogenesis. Her group also established protocols to identify the rare population of endothelial progenitor cells in mice using 8-colour flow cytometric analysis in in vivo mouse models of acute alcohol-induced liver injury.

Both projects have opportunities for Honours and PhD.

Associations

Memberships: Professional memberships- current: RSA, EASL, ISBRA, ALPD, Gastroenterology Society of Australia (GESA), European Society of Biomedical Research on Alcohol (ESBRA), Australian Medical Association (AMA), UK Biobank, Franklin Women.

Leadership and Organization: Clinical & Administrative

Treasurer, Research Society on Alcoholism (2018): RSA isa unique organisation in the world promoting alcohol research. Dr Seth election by members reflects her international standing in this field.

Editorial and Journal referee: Reviewer for more than 25 international journals and on editorial board of two.

Reviewer for grants:Include reviewing grants for NHMRC and international granting bodies, such as, Medical Research Council, UK (MRC, UK); The European Foundation for Alcohol Research (ERAB); German Academic Exchange (DAAD).

USYD HREC Executive member: Reviewing ethics applications and attending monthly HREC Executive meetings since 2011.

Project coordinator:Overseeing all aspects of the International GenomALC Consortium since 2008 and AISRF study since 2013.

Chair, Gender Equity Program (GEP), Centenary Institute (CI)

  • Involved in establishing awards for female researchers at CI
  • Developing strategies, policies and procedures for CI in line with NHMRC
  • Liaise with USYD Women in Science.
  • Received travel grant from Centenary Institute to attend Women in Health Sciences workshop conducted by NHMRC, Melbourne, 25th May 2015

Franklin Women Peer Advisory Committee, 2016-: Franklin Women is a peak body with a well-respected voice and passion to create a health and medical research sector where women thrive. Dr Seth’s role in Franklin Women includes developing events and programs, such as the cross-organisational Mentoring Program, to help promote, sustain and transition women within this sector.

  • Advise on strategies and priorities
  • Planning and executing events
  • Attend monthly meetings
  • Review carer travel scholarships for women twice a year
  • Mentoring Program 2017; 2018
  • Think Tank for FW Academic Partners

Awards and honours

Received several awards from professional alcohol/liver societies, such as the NIH, NIAAA, European Association for Study of Liver (EASL), International Society for Biomedical Research on Alcohol (ISBRA), Research Society on Alcoholism (RSA), Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ALPD) for international travel and organizing symposia/satellite meetings (2006-2014), and as visiting scientist from the Australia Academy of Science (AAS) in 2009. Chair, Gender Equity Program (GEP)

Recently honored as one of three outstanding women for their leadership and contribution to their respective research field by Prof Belinda Hutchinson (Chancellor, University of Sydney), Aug 2015

Received travel grant from Centenary Institute to attend Women in Health Sciences workshopconducted by NHMRC, Melbourne, 25th May 2015 and Franklin Women grant writing workshop, Nov 2015.

Under her leadership, the Gender Equity Program (GEP) received Team Excellence award for Centenary Institute and a $500 cheque.

Images of figures selected as front cover for Seth et al., J Hepatol 2006; J Hepatol 2008

In the media

Media and Community engagement

2017: Invited blog: http://www.broadagenda.com.au/home/insire-to-aspire-a-personal-approach/

By editors of BroadAgenda, 50/50 by 2030 Foundation, Institute for Governance and Policy Analysis, University of Canberra, March 2017

Invited speaker at the International Women’s Day March for Health, Economic, Representation & Safety, organised by NSW Union, Hyde Park 11th March [~2000 audience]

Sydney Morning Herald write up and video interview on Women in Science, Unconscious bias and Gender Equity Program at the Centenary Institute, and follow up of story by others

2016:Alcoholic Liver Disease Program

  • Feature in the Drug Health Services Newsletter “Year in Review 2016. The newsletter is Sydney Local Health District initiative showcasing area wide activities within the Drug Health Services.
  • Feature in INSPIRE Summer 2016 magazine. INSPIRE showcases cutting edge Australian health and medical research and discovery into disease areas that impact our lives.

2015

2012

Painting: especially watercolour. Have participated in several exhibitions in Perth, WA and Sydney. Won prizes-first, people choice, commended

Pottery: love to hand build. Exhibited in several exhibitions and won first prize and commended

Reading: Addicted to thrillers and mysteries but love reading scientists and artists biographies; collect books on multiple subjects-psychology, science, autobiographies

Music: Grew up with Indian Bollywood music so my being is immersed in that forever. Also love jazz, Caribbean music

Walking: to explore new places and think creatively

Cooking: and this is my passion. for me cooking is therapeutic - I love to cook fresh meals daily

Keywords

Genomics; Cell & Molecular Biology; Alcohol; Inflammation; Liver

Clinical Specialty

Gastroenterology and Hepatology

International links

Australia

(Queensland Institute of Medical Research, Brisbane) John B Whitfield, BSc, MSC, PhD, MRCPath, FRCPath is the Director a Senior Principal Research Fellow at the Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Drs Whitfield and Seth have had ~8 years of collaboration and held joint grants during this period.

France

(CHRU de Lille - Hôpital Huriez, Services des Maladies de l'Appareil digestif 1er étage Aile Est, Rue Michel Polonovski, 59037 LILLE Cedex, France) Philippe Mathurin, Professor of Medicine and specialist in hepatogastroeneterology. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

Germany

(Salem Medical Center, Heidelberg Centre of Alcohol Research Liver Disease and Nutrition, University of Heidelberg) Helmut Karl Seitz, M.D., PhD, AGAF is Professor, Medical Director, Department of Medicine, Salem Medical Center, Heidelberg; Head, Centre of Alcohol Research Liver Disease and Nutrition. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

India

(Clinical and Cellular Transplant Immunology & Department of Research, Institute of Liver and Biliary Sciences (ILBS). ) Dr Nirupama Trehanpati, Additional Professor and Dr Seth collaborate closely on a concurrent international AISRF project. The study is investigating the angiogenic and immunomodulatory role of bone-marrow (BM) derived endothelial progenitor cells (EPCs) in liver regeneration during alcohol induced injury. Drs Seth and Trehanpati lead the respective teams in Australia and India. They have visited each other's institutes and worked closely in developing this joint project. There has been substantial exchange of knowledge, technology and resources between the two teams during these visits

India

(Institute of Liver and Biliary Sciences, New Delhi, India) Prof Shiv Sarin, Director of the largest and most prestigious Institute of Liver and Biliary Science (ILBS), also the WHO viral hepatitis centre, is a principal investigator of the Indian team for the Australia India Strategic Research Fund collaborative project on "The immunomodulatory and angiogenic role of bone marrow-derived endothelial progenitor cells in chronic liver disease".

Switzerland

(University of Zurich, Switzerland) Felix Stickel, M.D. is Professor and GI specialist at the University of Zurich, Switzerland. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

United Kingdom

(University of Newcastle, UK) DAY, Christopher Paul, MD, MRCP, PhD, FRCP is Pro Vice Chancellor of Medical Sciences & Professor of Liver Medicine at the University of Newcastle, UK. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Prof Day and Dr Seth have also published together recently in Hepatology.

United States

(Indiana University, Bloomington, IN) Lawrence Lumeng, M.D. is a Professor, Physician/Scientist at the Indiana University, Bloomington, IN. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

United States

(University of California, LA Indiana school of Medicine, Indianpolis) Prof Tatiana Foroud, B.s, M.S, PhD is Professor of Medical & Molecular Genetics. She is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Dr Seth and Prof Foroud have jointly organised symposium on GWAS at the ISBRA 2008 meeting.

United States

(University of California-Irvine VA Medical Center, Long Beach CA) Timothy R, MORGAN, MD is Professor of Medicine, University of California, Irvine and Chief, Hepatology at the VA Medical Centre. He is the lead US Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011.

Selected grants

2015

  • Novel therapy approaches for diabetes and its liver and heart complications; Gorrell M, Keane F, Tu T, Shackel N, Bowen D, Bertolino P, Seth D, Chen J, Cook A, Liu R, Zheng X, Gamble J, McCaughan G; Rebecca L Cooper Medical Research Foundation/Research Support.

2014

  • The immunomodulatory and angiogenic role of bone marrow-derived endothelial progenitor cells in chronic liver disease; Seth D; Australia India Strategic Research Fund/Research Support.
  • Early identification of Alcoholic Liver Disease: investigating changes through genomics, epigenomics and immunoregulation studies; Seth D; Anonymous Philanthropic/Research Support.
  • Protease therapies for diabetes-associated liver disease; Gorrell M, Keane F, Cook A, Shackel N, Seth D, Chen J, Jolly C, Hare N, McCaughan G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • The immunomodulatory and angiogenic role of bone marrow-derived endothelial progenitor cells in chronic liver disease; Seth D, Haber P, McCaughan G, Gamble J, Duly A, Sarin S, Kaur S, Trehanpati N; Department of Industry, Innovation and Science/Australia-India Strategic Research Fund (AISRF).

2011

  • Genetic risk factors for alcoholic cirrhosis - genome wide case control study; Seth D, Haber P, Nalpas B, Stickel F, Day C, Lumeng L, Morgan T, Whitfield J; National Institutes of Health (USA)/Research Support.
  • THE ROLE OF OSTEOPONTIN (Opn) IN ALCOHOLIC LIVER INJURY; Seth D; DVC Research/Bridging Support Grant.
  • Genetics and molecular pathogenesis of ALD; Seth D; Anonymous Philanthropic/Research Support.

2010

  • Identification of co-morbidities associated with alcoholic liver disease; Seth D, Proude E; Alcohol Education and Rehabilitation Foundation/Research Grant.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

Selected publications

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Book Chapters

  • Paull, P., Haber, P., Seth, D. (2015). Drug testing and biomarkers of alcohol consumption. In Paul Haber, Carolyn Day, Michael Farrell (Eds.), Addiction Medicine: Principles and Practice, (pp. 143-162). Melbourne: IP Communications.
  • Lakshman, M., Garige, M., Gong, M., Leckey, L., Varatharajalu, R., Redman, R., Seth, D., Haber, P., Hirsch, K., Amdur, R., et al (2013). CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism. In Aparajita Dey (Eds.), Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism, (pp. 199-233). Dordrecht: Springer Science+Business Media. [More Information]
  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers. [More Information]

Journals

  • Nguyen, V., Haber, P., Seth, D. (2018). Applications and Challenges for the use of Phosphatidylethanol Testing in Liver Disease Patients (MINI REVIEW). Alcoholism: Clinical and Experimental Research, 42(2), 238-243. [More Information]
  • Kaur, S., Sehgal, R., Shastry, S., McCaughan, G., McGuire, H., Fazekas de St Groth, B., Sarin, S., Trehanpati, N., Seth, D. (2018). Circulating endothelial progenitor cells present an inflammatory phenotype and function in patients with alcoholic liver cirrhosis. Frontiers in Physiology, 9, 1-10. [More Information]
  • Nguyen, V., Paull, P., Haber, P., Chitty, K., Seth, D. (2018). Evaluation of a novel method for the analysis of alcohol biomarkers: Ethyl glucuronide, ethyl sulfate and phosphatidylethanol. Alcohol, 67, 7-13. [More Information]
  • Whitfield, J., Masson, S., Liangpunsakul, S., Hyman, J., Mueller, S., Aithal, G., Eyer, F., Gleeson, D., Thompson, A., Haber, P., Seth, D., et al (2018). Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis. Alcohol, 66, 1-7. [More Information]
  • Nguyen, V., Seth, D. (2018). Letter to the Editor Regarding Afshar et�al (2017): Cut-Point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort Including Critically Ill Patients. Alcoholism: Clinical and Experimental Research, 42(10), 2061-2063. [More Information]
  • Morley, K., Baillie, A., van den Brink, W., Chitty, K., Brady, K., Back, S., Seth, D., Sutherland, G., Leggio, L., Haber, P. (2018). N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research. Expert Opinion on Investigational Drugs, 27(8), 667-675. [More Information]
  • Morley, K., Baillie, A., van den Brink, W., Chitty, K., Brady, K., Back, S., Seth, D., Sutherland, G., Leggio, L., Haber, P. (2018). Rationale for N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease. Expert Opinion on Investigational Drugs, 27(8), 667-675. [More Information]
  • Grzelak, C., Sigglekow, N., Tirnitz-Parker, J., Hamson, E., Warren, A., Maneck, B., Chen, J., Patkunanathan, B., Boland, J., Cheng, R., Shackel, N., Seth, D., Bowen, D., McCaughan, G., et al (2017). Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease. PloS One, 12(2), 1-23. [More Information]
  • Anstee, Q., Seth, D., Day, C. (2016). Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease. Gastroenterology, 150(8), 1728-1744. [More Information]
  • Whitfield, J., Rahman, K., Haber, P., Day, C., Masson, S., Daly, A., Cordell, H., Mueller, S., Seitz, H., Liangpunsakul, S., Seth, D., et al (2015). Brief report: Genetics of alcoholic Cirrhosis-GenomALC multinational study. Alcoholism: Clinical and Experimental Research, 39(5), 836-842. [More Information]
  • Meikle, P., Mundra, P., Wong, G., Rahman, K., Huynh, K., Barlow, C., Duly, A., Haber, P., Whitfield, J., Seth, D. (2015). Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. PloS One, 10(6), 1-13. [More Information]
  • Duly, A., Alani, B., Huang, E., Yee, C., Haber, P., McLennan, S., Seth, D. (2015). Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity. Nutrition and Diabetes, 5, 1-9. [More Information]
  • Salameh, H., Raff, E., Erwin, A., Seth, D., Nischalke, H., Falleti, E., Burza, M., Leathert, J., Romeo, S., Molinaro, A., et al (2015). PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease. American Journal of Gastroenterology, 110(6), 846-856. [More Information]
  • Neuman, M., French, S., French, B., Seitz, H., Cohen, L., Osna, N., Kharbanda, K., Seth, D., Bautista, A., Thompson, K., et al (2014). Alcoholic and non-alcoholic steatohepatitis. Experimental and Molecular Pathology, 97(3), 492-510. [More Information]
  • Seth, D., Duly, A., Kuo, P., McCaughan, G., Haber, P. (2014). Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation. World Journal of Gastroenterology, 20(36), 13088-13104. [More Information]
  • Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
  • Phillips, R., Helbig, K., Van der Hoek, K., Seth, D., Beard, M. (2012). Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World Journal of Gastroenterology, 18(26), 3389-3399. [More Information]
  • Seth, D., Haber, P., Syn, W., Diehl, A., Day, C. (2011). Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances. Journal of Gastroenterology and Hepatology, 26(7), 1089-1105. [More Information]
  • Seth, D., El-Guindy, N., Apte, M., Mari, M., Dooley, S., Neuman, M., Haber, P., Kundu, G., Darwanto, A., De Villiers, W., et al (2010). Alcohol, Signaling, and ECM Turnover. Alcoholism: Clinical and Experimental Research, 34(11), 1-15. [More Information]
  • Seth, D., Daly, A., Haber, P., Day, C. (2010). Patatin-like phospholipase domain containing 3: a case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease. Hepatology, 51(4), 1463-1465. [More Information]
  • Gong, M., Castillo, L., Redman, R., Garige, M., Hirsch, K., Azuine, M., Amdur, R., Seth, D., Haber, P., Lakshmanan, M. (2008). Down-regulation of liver Galβ1, 4GlcNAc α2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Metabolism: Clinical and Experimental, 57(12), 1663-1668. [More Information]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive Diseases and Sciences, 53(6), 1468-1487. [More Information]
  • Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
  • Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
  • Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]
  • Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. American Journal of Pathology, 163(6), 2303-2317. [More Information]
  • Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344. [More Information]
  • Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66. [More Information]

Conferences

  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.

2018

  • Nguyen, V., Haber, P., Seth, D. (2018). Applications and Challenges for the use of Phosphatidylethanol Testing in Liver Disease Patients (MINI REVIEW). Alcoholism: Clinical and Experimental Research, 42(2), 238-243. [More Information]
  • Kaur, S., Sehgal, R., Shastry, S., McCaughan, G., McGuire, H., Fazekas de St Groth, B., Sarin, S., Trehanpati, N., Seth, D. (2018). Circulating endothelial progenitor cells present an inflammatory phenotype and function in patients with alcoholic liver cirrhosis. Frontiers in Physiology, 9, 1-10. [More Information]
  • Nguyen, V., Paull, P., Haber, P., Chitty, K., Seth, D. (2018). Evaluation of a novel method for the analysis of alcohol biomarkers: Ethyl glucuronide, ethyl sulfate and phosphatidylethanol. Alcohol, 67, 7-13. [More Information]
  • Whitfield, J., Masson, S., Liangpunsakul, S., Hyman, J., Mueller, S., Aithal, G., Eyer, F., Gleeson, D., Thompson, A., Haber, P., Seth, D., et al (2018). Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis. Alcohol, 66, 1-7. [More Information]
  • Nguyen, V., Seth, D. (2018). Letter to the Editor Regarding Afshar et�al (2017): Cut-Point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort Including Critically Ill Patients. Alcoholism: Clinical and Experimental Research, 42(10), 2061-2063. [More Information]
  • Morley, K., Baillie, A., van den Brink, W., Chitty, K., Brady, K., Back, S., Seth, D., Sutherland, G., Leggio, L., Haber, P. (2018). N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research. Expert Opinion on Investigational Drugs, 27(8), 667-675. [More Information]
  • Morley, K., Baillie, A., van den Brink, W., Chitty, K., Brady, K., Back, S., Seth, D., Sutherland, G., Leggio, L., Haber, P. (2018). Rationale for N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease. Expert Opinion on Investigational Drugs, 27(8), 667-675. [More Information]

2017

  • Grzelak, C., Sigglekow, N., Tirnitz-Parker, J., Hamson, E., Warren, A., Maneck, B., Chen, J., Patkunanathan, B., Boland, J., Cheng, R., Shackel, N., Seth, D., Bowen, D., McCaughan, G., et al (2017). Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease. PloS One, 12(2), 1-23. [More Information]

2016

  • Anstee, Q., Seth, D., Day, C. (2016). Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease. Gastroenterology, 150(8), 1728-1744. [More Information]

2015

  • Whitfield, J., Rahman, K., Haber, P., Day, C., Masson, S., Daly, A., Cordell, H., Mueller, S., Seitz, H., Liangpunsakul, S., Seth, D., et al (2015). Brief report: Genetics of alcoholic Cirrhosis-GenomALC multinational study. Alcoholism: Clinical and Experimental Research, 39(5), 836-842. [More Information]
  • Meikle, P., Mundra, P., Wong, G., Rahman, K., Huynh, K., Barlow, C., Duly, A., Haber, P., Whitfield, J., Seth, D. (2015). Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. PloS One, 10(6), 1-13. [More Information]
  • Paull, P., Haber, P., Seth, D. (2015). Drug testing and biomarkers of alcohol consumption. In Paul Haber, Carolyn Day, Michael Farrell (Eds.), Addiction Medicine: Principles and Practice, (pp. 143-162). Melbourne: IP Communications.
  • Duly, A., Alani, B., Huang, E., Yee, C., Haber, P., McLennan, S., Seth, D. (2015). Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity. Nutrition and Diabetes, 5, 1-9. [More Information]
  • Salameh, H., Raff, E., Erwin, A., Seth, D., Nischalke, H., Falleti, E., Burza, M., Leathert, J., Romeo, S., Molinaro, A., et al (2015). PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease. American Journal of Gastroenterology, 110(6), 846-856. [More Information]

2014

  • Neuman, M., French, S., French, B., Seitz, H., Cohen, L., Osna, N., Kharbanda, K., Seth, D., Bautista, A., Thompson, K., et al (2014). Alcoholic and non-alcoholic steatohepatitis. Experimental and Molecular Pathology, 97(3), 492-510. [More Information]
  • Seth, D., Duly, A., Kuo, P., McCaughan, G., Haber, P. (2014). Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation. World Journal of Gastroenterology, 20(36), 13088-13104. [More Information]
  • Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]

2013

  • Lakshman, M., Garige, M., Gong, M., Leckey, L., Varatharajalu, R., Redman, R., Seth, D., Haber, P., Hirsch, K., Amdur, R., et al (2013). CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism. In Aparajita Dey (Eds.), Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism, (pp. 199-233). Dordrecht: Springer Science+Business Media. [More Information]

2012

  • Phillips, R., Helbig, K., Van der Hoek, K., Seth, D., Beard, M. (2012). Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World Journal of Gastroenterology, 18(26), 3389-3399. [More Information]

2011

  • Seth, D., Haber, P., Syn, W., Diehl, A., Day, C. (2011). Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances. Journal of Gastroenterology and Hepatology, 26(7), 1089-1105. [More Information]

2010

  • Seth, D., El-Guindy, N., Apte, M., Mari, M., Dooley, S., Neuman, M., Haber, P., Kundu, G., Darwanto, A., De Villiers, W., et al (2010). Alcohol, Signaling, and ECM Turnover. Alcoholism: Clinical and Experimental Research, 34(11), 1-15. [More Information]
  • Seth, D., Daly, A., Haber, P., Day, C. (2010). Patatin-like phospholipase domain containing 3: a case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease. Hepatology, 51(4), 1463-1465. [More Information]

2008

  • Gong, M., Castillo, L., Redman, R., Garige, M., Hirsch, K., Azuine, M., Amdur, R., Seth, D., Haber, P., Lakshmanan, M. (2008). Down-regulation of liver Galβ1, 4GlcNAc α2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Metabolism: Clinical and Experimental, 57(12), 1663-1668. [More Information]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive Diseases and Sciences, 53(6), 1468-1487. [More Information]

2007

  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers. [More Information]

2006

  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
  • Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
  • Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]

2003

  • Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. American Journal of Pathology, 163(6), 2303-2317. [More Information]
  • Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344. [More Information]
  • Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66. [More Information]

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