Dr Daniel Johnstone

NHMRC Early Career Fellow
Bosch Institute, School of Medical Sciences

Telephone +61 2 9351 5162
Fax +61 2 9351 6470

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Selected grants

2014

  • Protection against Parkinsons disease using remote photobiomodulation: understanding mechanisms; Johnstone D, Stone J, Mitrofanis J; Brain Foundation of Australia/Annual Research Awards.
  • La Vision BioTec Ultramicroscope; Murphy C, Braet F, Byrne M, Chan-Ling T, Fraser S, Goldsbury C, Halliday G, Hambly B, Johnstone D, Keay K, Lovelace M, Lyons G, Mason R, Overall R, Owens T, Richardson D, Stone J, Weiss A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Assessing the efficacy of safe and simple neuroprotective treatments for chronic degenerative conditions of the central nervous system; Johnstone D; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Book Chapters

  • Milward, E., Acikyol, B., Bassett, B., Williams, E., Graham, R., Delima, R., Trinder, D., Olynyk, J., Johnstone, D. (2012). Brain changes in iron loading disorders. In Wolfgang Linert, Henryk Kozlowski (Eds.), Metal Ions in Neurological Systems, (pp. 17-29). Vienna: Springer.
  • Parsons, C., Koolwijk, I., Roy, T., Roy, C., Johnstone, D., Vos, C., Conant, K., Milward, E. (2005). Matrix Metalloproteinases and Related Proteins in Alzheimer's Disease, Parkinson's Disease and other Neurodegenerative Disorders. In Katherine Conant, Paul E Gottschall (Eds.), Matrix Metalloproteinases In The Central Nervous System, (pp. 279-310). Covent Garden, London, UK: Imperial College Press.

Journals

  • Milward, E., Moscato, P., Riveros, C., Johnstone, D. (2014). Beyond Statistics: a New Combinatorial Approach to Identifying Biomarker Panels for the Early Detection and Diagnosis of Alzheimer's Disease. Journal of Alzheimer's Disease, 39(1), 211-217. [More Information]
  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274(C), 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Johnstone, D., Coleman, K., Moro, C., Torres, N., Eells, J., Baker, G., Ashkan, K., Stone, J., Benabid, A., Mitrofanis, J. (2014). The potential of light therapy in Parkinson's disease. ChronoPhysiology and Therapy, 4, 1-14. [More Information]
  • Acikyol, B., Graham, R., Trinder, D., House, M., Olynyk, J., Scott, R., Milward, E., Johnstone, D. (2013). Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation. Neuroscience, 235, 119-128. [More Information]
  • Johnstone, D., Riveros, C., Heidari, M., Graham, R., Trinder, D., Berretta, R., Olynyk, J., Scott, R., Moscato, P., Milward, E. (2013). Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Microarray Data Involving Small Changes. Microarrays, 2(2), 131-152. [More Information]
  • Moro, C., Torres, N., El Massri, N., Ratel, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A. (2013). Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. BMC Neuroscience, 14(1), 1-9. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]
  • Purushothuman, S., Marotte, L., Stowe, S., Johnstone, D., Stone, J. (2013). The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model. PloS One, 8(3), 1-18. [More Information]
  • Johnstone, D., Graham, R., Trinder, D., Delima, R., Riveros, C., Olynyk, J., Scott, R., Moscato, P., Milward, E. (2012). Brain transcriptome perturbations in the Hfe −/− mouse model of genetic iron loading. Brain Research, 1448 (11 April 2012), 144-152. [More Information]
  • Johnstone, D., Graham, R., Trinder, D., Riveros, C., Olynyk, J., Scott, R., Moscato, P., Milward, E. (2012). Changes in Brain Transcripts Related to Alzheimer’s Disease in a Model of HFE Hemochromatosis are not Consistent with Increased Alzheimer’s Disease Risk. Journal of Alzheimer's Disease, 30(4), 791-803. [More Information]
  • Milward, E., Daneshi, N., Johnstone, D. (2012). Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery. Pharmacology and Therapeutics, 136(3), 295-304. [More Information]
  • Johnstone, D., Milward, E., Berretta, R., Moscato, P. (2012). Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset. PloS One, 7(4), 1-17. [More Information]
  • de Bock, C., Ardjmand, A., Molloy, T., Bone, S., Johnstone, D., Campbell, D., Shipman, K., Yeadon, T., Holst, J., Spanevello, M., Catchpoole, D., et al (2012). The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. Leukemia, 26(5), 918-926. [More Information]
  • Arefin, A., Mathieson, L., Johnstone, D., Berretta, R., Moscato, P. (2012). Unveiling Clusters of RNA Transcript Pairs Associated with Markers of Alzheimer's Disease Progression. PloS One, 7(9), 1-25. [More Information]
  • Johnstone, D., Milward, E. (2010). Genome-wide microarray analysis of brain gene expression in mice on a short-term high iron diet. Neurochemistry International, 56, 856-863.
  • Graham, R., Chua, A., Carter, K., Delima, R., Johnstone, D., Herbison, C., Firth, M., O'Leary, R., Milward, E., Olynyk, J., et al (2010). Hepatic Iron Loading in Mice Increases Cholesterol Biosynthesis. Hepatology, 52(2), 462-471.
  • Johnstone, D., Milward, E. (2010). Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease. Journal of Neurochemistry, 113, 1387-1402.
  • Shi, Z., Johnstone, D., Talseth-Palmer, B., Evans, T., Spigelman, A., Groombridge, C., Milward, E., Olynyk, J., Suchy, J., Kurzawski, G., et al (2009). Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age. International Journal of Cancer, 125, 78-83.
  • Milward, E., Johnstone, D., Trinder, D., Ramm, G., Olynyk, J. (2007). The Nexus of Iron and Inflammation in Hepcidin Regulation: SMADs, STATs, and ECSIT. Hepatology, 45(1), 253-256.

Conferences

  • Stone, J., Johnstone, D., Mitrofanis, J. (2013). The helmet experiment in Parkinson's disease: an observation of the mechanism of neuroprotection by near infra-red light. The 9th World Association for Laser Therapy Congress, Bologna, Italy: Medimond International Proceedings.
  • Johnstone, D., Graham, R., Trinder, D., Scott, R., Olynyk, J., Moscato, P., Milward, E. (2012). Microarray analysis of brain expression changes for genes relating to Alzheimer's disease and other neurodegenerative disorders in mouse models of iron overload. International Conference on Alzheimer's Disease, Honolulu, HI, USA.
  • Graham, R., Chua, A., Delima, R., Johnstone, D., Milward, E., Olynyk, J., Trinder, D. (2011). Genes involved in cholesterol sorting are upregulated with hepatic iron loading. Hepatology and Luminal Research Workshop, Kiama, NSW, Australia.
  • Graham, R., Chua, A., Delima, R., Johnstone, D., Milward, E., Olynyk, J., Trinder, D. (2011). Upregulation of genes involved in cholesterol sorting in the face of hepatic iron loading. BioIron Society 2011 Meeting, Vancouver, BC, Canada.
  • Johnstone, D., Gomez Ravetti, M., Rosso, O., Berretta, R., Milward, E., Moscato, P. (2010). A molecular signature of cognitive decline involveing altered expression of metal-related genes in the hippocampus of Alzheimer's disease patients. Biomarker Discovery Conference, Shoal Bay, NSW, Australia.
  • Johnstone, D., Acikyol, B., Graham, R., Trinder, D., Scott, R., Olynyk, J., Moscato, P., Milward, E. (2010). Gene expression studies in three different mouse models support the case for neurologic sequelae overload disorders and provide new insights into mechanism. Neuroscience 2010, San Diego, CA, USA.
  • Milward, E., Hollins, S., Graham, R., van Balen, M., Trinder, D., Olynyk, J., Cairns, M., Johnstone, D. (2010). Iron overload and melanin systems in the retina - a new mechanism for retinal degeneration? Neuroscience 2010, San Diego, CA, USA.
  • Graham, R., Chua, A., Delima, R., Johnstone, D., Milward, E., Olynyk, J., Trinder, D. (2010). Upregulation of genes involved in cholesterol sorting in the face of hepatic iron loading. Boden Research Conference, Canberra, ACT, Australia.
  • Johnstone, D., Gomez Ravetti, M., Moscato, P., Hersey, P., Scott, R., Milward, E. (2009). Metabolic gene expression in advanced melanoma. ASMR NSW State Scientific Meeting, Sydney, NSW, Australia.
  • Milward, E., Johnstone, D., Gomez Ravetti, M., Berretta, R., Hersey, P., Scott, R., Moscato, P. (2009). The relationship between Parkinson's disease and melanoma - insights from microarray analysis of genome-wide gene expression changes in melanoma. ASMR National Scientific Conference, Hobart, TAS, Australia.

2014

  • Milward, E., Moscato, P., Riveros, C., Johnstone, D. (2014). Beyond Statistics: a New Combinatorial Approach to Identifying Biomarker Panels for the Early Detection and Diagnosis of Alzheimer's Disease. Journal of Alzheimer's Disease, 39(1), 211-217. [More Information]
  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274(C), 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Johnstone, D., Coleman, K., Moro, C., Torres, N., Eells, J., Baker, G., Ashkan, K., Stone, J., Benabid, A., Mitrofanis, J. (2014). The potential of light therapy in Parkinson's disease. ChronoPhysiology and Therapy, 4, 1-14. [More Information]

2013

  • Acikyol, B., Graham, R., Trinder, D., House, M., Olynyk, J., Scott, R., Milward, E., Johnstone, D. (2013). Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation. Neuroscience, 235, 119-128. [More Information]
  • Johnstone, D., Riveros, C., Heidari, M., Graham, R., Trinder, D., Berretta, R., Olynyk, J., Scott, R., Moscato, P., Milward, E. (2013). Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Microarray Data Involving Small Changes. Microarrays, 2(2), 131-152. [More Information]
  • Moro, C., Torres, N., El Massri, N., Ratel, D., Johnstone, D., Stone, J., Mitrofanis, J., Benabid, A. (2013). Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. BMC Neuroscience, 14(1), 1-9. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Stone, J., Johnstone, D., Mitrofanis, J. (2013). The helmet experiment in Parkinson's disease: an observation of the mechanism of neuroprotection by near infra-red light. The 9th World Association for Laser Therapy Congress, Bologna, Italy: Medimond International Proceedings.
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]
  • Purushothuman, S., Marotte, L., Stowe, S., Johnstone, D., Stone, J. (2013). The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model. PloS One, 8(3), 1-18. [More Information]

2012

  • Milward, E., Acikyol, B., Bassett, B., Williams, E., Graham, R., Delima, R., Trinder, D., Olynyk, J., Johnstone, D. (2012). Brain changes in iron loading disorders. In Wolfgang Linert, Henryk Kozlowski (Eds.), Metal Ions in Neurological Systems, (pp. 17-29). Vienna: Springer.
  • Johnstone, D., Graham, R., Trinder, D., Delima, R., Riveros, C., Olynyk, J., Scott, R., Moscato, P., Milward, E. (2012). Brain transcriptome perturbations in the Hfe −/− mouse model of genetic iron loading. Brain Research, 1448 (11 April 2012), 144-152. [More Information]
  • Johnstone, D., Graham, R., Trinder, D., Riveros, C., Olynyk, J., Scott, R., Moscato, P., Milward, E. (2012). Changes in Brain Transcripts Related to Alzheimer’s Disease in a Model of HFE Hemochromatosis are not Consistent with Increased Alzheimer’s Disease Risk. Journal of Alzheimer's Disease, 30(4), 791-803. [More Information]
  • Milward, E., Daneshi, N., Johnstone, D. (2012). Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery. Pharmacology and Therapeutics, 136(3), 295-304. [More Information]
  • Johnstone, D., Graham, R., Trinder, D., Scott, R., Olynyk, J., Moscato, P., Milward, E. (2012). Microarray analysis of brain expression changes for genes relating to Alzheimer's disease and other neurodegenerative disorders in mouse models of iron overload. International Conference on Alzheimer's Disease, Honolulu, HI, USA.
  • Johnstone, D., Milward, E., Berretta, R., Moscato, P. (2012). Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset. PloS One, 7(4), 1-17. [More Information]
  • de Bock, C., Ardjmand, A., Molloy, T., Bone, S., Johnstone, D., Campbell, D., Shipman, K., Yeadon, T., Holst, J., Spanevello, M., Catchpoole, D., et al (2012). The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. Leukemia, 26(5), 918-926. [More Information]
  • Arefin, A., Mathieson, L., Johnstone, D., Berretta, R., Moscato, P. (2012). Unveiling Clusters of RNA Transcript Pairs Associated with Markers of Alzheimer's Disease Progression. PloS One, 7(9), 1-25. [More Information]

2011

  • Graham, R., Chua, A., Delima, R., Johnstone, D., Milward, E., Olynyk, J., Trinder, D. (2011). Genes involved in cholesterol sorting are upregulated with hepatic iron loading. Hepatology and Luminal Research Workshop, Kiama, NSW, Australia.
  • Graham, R., Chua, A., Delima, R., Johnstone, D., Milward, E., Olynyk, J., Trinder, D. (2011). Upregulation of genes involved in cholesterol sorting in the face of hepatic iron loading. BioIron Society 2011 Meeting, Vancouver, BC, Canada.

2010

  • Johnstone, D., Gomez Ravetti, M., Rosso, O., Berretta, R., Milward, E., Moscato, P. (2010). A molecular signature of cognitive decline involveing altered expression of metal-related genes in the hippocampus of Alzheimer's disease patients. Biomarker Discovery Conference, Shoal Bay, NSW, Australia.
  • Johnstone, D., Acikyol, B., Graham, R., Trinder, D., Scott, R., Olynyk, J., Moscato, P., Milward, E. (2010). Gene expression studies in three different mouse models support the case for neurologic sequelae overload disorders and provide new insights into mechanism. Neuroscience 2010, San Diego, CA, USA.
  • Johnstone, D., Milward, E. (2010). Genome-wide microarray analysis of brain gene expression in mice on a short-term high iron diet. Neurochemistry International, 56, 856-863.
  • Graham, R., Chua, A., Carter, K., Delima, R., Johnstone, D., Herbison, C., Firth, M., O'Leary, R., Milward, E., Olynyk, J., et al (2010). Hepatic Iron Loading in Mice Increases Cholesterol Biosynthesis. Hepatology, 52(2), 462-471.
  • Milward, E., Hollins, S., Graham, R., van Balen, M., Trinder, D., Olynyk, J., Cairns, M., Johnstone, D. (2010). Iron overload and melanin systems in the retina - a new mechanism for retinal degeneration? Neuroscience 2010, San Diego, CA, USA.
  • Johnstone, D., Milward, E. (2010). Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease. Journal of Neurochemistry, 113, 1387-1402.
  • Graham, R., Chua, A., Delima, R., Johnstone, D., Milward, E., Olynyk, J., Trinder, D. (2010). Upregulation of genes involved in cholesterol sorting in the face of hepatic iron loading. Boden Research Conference, Canberra, ACT, Australia.

2009

  • Shi, Z., Johnstone, D., Talseth-Palmer, B., Evans, T., Spigelman, A., Groombridge, C., Milward, E., Olynyk, J., Suchy, J., Kurzawski, G., et al (2009). Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age. International Journal of Cancer, 125, 78-83.
  • Johnstone, D., Gomez Ravetti, M., Moscato, P., Hersey, P., Scott, R., Milward, E. (2009). Metabolic gene expression in advanced melanoma. ASMR NSW State Scientific Meeting, Sydney, NSW, Australia.
  • Milward, E., Johnstone, D., Gomez Ravetti, M., Berretta, R., Hersey, P., Scott, R., Moscato, P. (2009). The relationship between Parkinson's disease and melanoma - insights from microarray analysis of genome-wide gene expression changes in melanoma. ASMR National Scientific Conference, Hobart, TAS, Australia.

2007

  • Milward, E., Johnstone, D., Trinder, D., Ramm, G., Olynyk, J. (2007). The Nexus of Iron and Inflammation in Hepcidin Regulation: SMADs, STATs, and ECSIT. Hepatology, 45(1), 253-256.

2005

  • Parsons, C., Koolwijk, I., Roy, T., Roy, C., Johnstone, D., Vos, C., Conant, K., Milward, E. (2005). Matrix Metalloproteinases and Related Proteins in Alzheimer's Disease, Parkinson's Disease and other Neurodegenerative Disorders. In Katherine Conant, Paul E Gottschall (Eds.), Matrix Metalloproteinases In The Central Nervous System, (pp. 279-310). Covent Garden, London, UK: Imperial College Press.

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