Dr Daniel Speidel

Senior Lecturer
Research Group Leader
Medicine, Children's Medical Research Institute

Telephone +61 2 9687 2800
Fax 96872120

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Biographical details

2004 PhD Biochemistry, University Hannover, Germany

2004-2007 Postdoctoral Fellow Heinrich-Pette-Institute Hamburg

2007-present Junior Research Group Leader Children's Medical Research Institute

Research interests

DNA damage responses, apoptosis, cell cycle regulation, p53, RUNX1

International links

United Kingdom

(University of Kent) Research collaboration on p53-activating drugs with Prof Martin Michaelis

Selected grants

2012

  • DNA damage induced cell cycle alterations: how significant are they for tumour suppression and the response of different tissues to cytotoxic agents in vivo?; Speidel D; Cure Cancer Australia Foundation/Research Support.

Selected publications

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Journals

  • Michaelis, M., Rothweiler, F., Agha, B., Barth, S., Voges, Y., Loschmann, N., von Deimling, A., Breitling, R., Doerr, H., Rodel, F., Speidel, D., et al (2012). Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents. Cell Death and Disease, 3(4), 1-8. [More Information]
  • Michaelis, M., Rothweiler, F., Barth, S., Cinatl, J., Van Rikxoort, M., Löschmann, N., Voges, Y., Breitling, R., von Deimling, A., Rödel, F., Speidel, D., et al (2011). Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death and Disease, 2(12), e243 - 1-e243 - 8. [More Information]
  • Heinlein, C., Speidel, D. (2011). High-resolution cell cycle and DNA ploidy analysis in tissue samples. Current Protocols in Cytometry, 7(39), 1-11. [More Information]
  • Speidel, D. (2011). The magic trick of hepatocytes: uncoupling genomic instability from cancer. Trends in Molecular Medicine, 17(3), 117-118. [More Information]
  • Heinlein, C., Deppert, W., Braithwaite, A., Speidel, D. (2010). A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry. Cell Cycle, 9(17), 3584-3590. [More Information]
  • Speidel, D., Stocking, C. (2010). Caspase 3 activity in whole cell extracts of Ba/F3 cells is unrelated to apoptosis. Cell Cycle, 9(18), 3823-5. [More Information]
  • Kim, E., Wustenberg, R., Rubsam, A., Schmitz-Salue, C., Warnecke, G., Bucker, E., Pettkus, N., Speidel, D., Rohde, V., Schulz-Schaeffer, W., et al (2010). Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells. Neuro-Oncology, 12(4), 389-400. [More Information]
  • Speidel, D. (2010). Transcription-independent p53 apoptosis: an alternative route to death. Trends in Cell Biology, 20(1), 14-24. [More Information]
  • Engelmann, A., Speidel, D., Bornkamm, G., Deppert, W., Stocking, C. (2008). Gadd45 beta is a pro-survival factor associated with stress-resistant tumors. Oncogene, 27(10), 1429-38. [More Information]
  • Heinlein, C., Krepulat, F., Lohler, J., Speidel, D., Deppert, W., Tolstonog, G. (2008). Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis. International Journal of Cancer, 122(8), 1701-9. [More Information]
  • Speidel, D., Helmbold, H., Deppert, W. (2006). Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress. Oncogene, 25(6), 940-53. [More Information]
  • Will, E., Speidel, D., Ghiaur, G., Rimek, A., Schiedlmeier, B., Williams, D., Baum, C., Ostertag, W., Klump, H. (2006). HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues. Cell Cycle, 5(1), 14-22. [More Information]
  • Stoter, M., Bamberger, A., Aslan, B., Kurth, M., Speidel, D., Loning, T., Frank, H., Kaufmann, P., Lohler, J., Henne Bruns, D., et al (2005). Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene, 24(54), 7964-75. [More Information]
  • Moll, U., Wolff, S., Speidel, D., Deppert, W. (2005). Transcription-independent pro-apoptotic functions of p53. Current Opinion in Cell Biology, 17(6), 631-6. [More Information]

2012

  • Michaelis, M., Rothweiler, F., Agha, B., Barth, S., Voges, Y., Loschmann, N., von Deimling, A., Breitling, R., Doerr, H., Rodel, F., Speidel, D., et al (2012). Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents. Cell Death and Disease, 3(4), 1-8. [More Information]

2011

  • Michaelis, M., Rothweiler, F., Barth, S., Cinatl, J., Van Rikxoort, M., Löschmann, N., Voges, Y., Breitling, R., von Deimling, A., Rödel, F., Speidel, D., et al (2011). Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death and Disease, 2(12), e243 - 1-e243 - 8. [More Information]
  • Heinlein, C., Speidel, D. (2011). High-resolution cell cycle and DNA ploidy analysis in tissue samples. Current Protocols in Cytometry, 7(39), 1-11. [More Information]
  • Speidel, D. (2011). The magic trick of hepatocytes: uncoupling genomic instability from cancer. Trends in Molecular Medicine, 17(3), 117-118. [More Information]

2010

  • Heinlein, C., Deppert, W., Braithwaite, A., Speidel, D. (2010). A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry. Cell Cycle, 9(17), 3584-3590. [More Information]
  • Speidel, D., Stocking, C. (2010). Caspase 3 activity in whole cell extracts of Ba/F3 cells is unrelated to apoptosis. Cell Cycle, 9(18), 3823-5. [More Information]
  • Kim, E., Wustenberg, R., Rubsam, A., Schmitz-Salue, C., Warnecke, G., Bucker, E., Pettkus, N., Speidel, D., Rohde, V., Schulz-Schaeffer, W., et al (2010). Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells. Neuro-Oncology, 12(4), 389-400. [More Information]
  • Speidel, D. (2010). Transcription-independent p53 apoptosis: an alternative route to death. Trends in Cell Biology, 20(1), 14-24. [More Information]

2008

  • Engelmann, A., Speidel, D., Bornkamm, G., Deppert, W., Stocking, C. (2008). Gadd45 beta is a pro-survival factor associated with stress-resistant tumors. Oncogene, 27(10), 1429-38. [More Information]
  • Heinlein, C., Krepulat, F., Lohler, J., Speidel, D., Deppert, W., Tolstonog, G. (2008). Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis. International Journal of Cancer, 122(8), 1701-9. [More Information]

2006

  • Speidel, D., Helmbold, H., Deppert, W. (2006). Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress. Oncogene, 25(6), 940-53. [More Information]
  • Will, E., Speidel, D., Ghiaur, G., Rimek, A., Schiedlmeier, B., Williams, D., Baum, C., Ostertag, W., Klump, H. (2006). HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues. Cell Cycle, 5(1), 14-22. [More Information]

2005

  • Stoter, M., Bamberger, A., Aslan, B., Kurth, M., Speidel, D., Loning, T., Frank, H., Kaufmann, P., Lohler, J., Henne Bruns, D., et al (2005). Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene, 24(54), 7964-75. [More Information]
  • Moll, U., Wolff, S., Speidel, D., Deppert, W. (2005). Transcription-independent pro-apoptotic functions of p53. Current Opinion in Cell Biology, 17(6), 631-6. [More Information]

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