Associate Professor Daniela Traini

ARC Future Fellow
Pharmacology, School of Medical Sciences
Woolcock Institute of Medical Research

Telephone +61 2 91140352

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Biographical details

Associate Professor Daniela Traini is an ARC Future Fellow and her research portfolio covers all areas of respiratory research, from bench to bedside.Dr Trainihas completed her PhD in June 2005 under the primary supervision of Dr. Robert Price, at the University of Bath, UK.Dr Traini is part of the Respiratory Technology group at the Woolcock Institute for Medical Research and works in collaboration with Associate Professor Young.Associate Professor Traini is an emerging international leader in pulmonary drug delivery. Over the last 9 years since joining the University of Sydney, and before during her 5 years in industry, she had developed a leading research program on aerosol drug delivery, ranging from powder engineering, aerosol generation and characterisation in vitro to in vivo lung deposition and clinical outcomes.She has extensive experience in both academic and industrial pharmaceutics, and still retains strong link with the pharmaceutical industry. She has published over 100 full peer reviewed manuscripts, has 5 patents and has attracted more then $9 Millions in competitive funding.

Research interests

General interests are into all areas of pharmaceutical technology and surface material science including: investigation into surface energy and particle interactions; characterisation and optimisation of pharmaceutical materials used in dry powder and pressurised metered dose inhalers; evaluation of controlled release formulations for both inhalation and other biological applications.

International links

Italy

(A/Prof Paola Russo-University of Salerno) Student exchange

Italy

(The University of Ferrara-Prof Santo Scalia) Honors and PhD exchange and Cotutelle Agrement

Italy

(The University of Parma-Prof Paolo Colombo) Honors and Phd exchange- Faculty of Pharmacy

United Kingdom

(University College London-School of Pharmacy) Collaboration with Prof Simon Gaisford for PhD exchange

Selected grants

2014

  • One for all and all for one: Engineering a drug delivery platform for DNA vaccines to the lung; Traini D, Young P, Windhab N; Australian Research Council (ARC)/Linkage Projects (LP).
  • CSI-Sydney: New technologies to treat chronic sinus infection; Young P, Traini D, King G, Bailey D, Whitchurch C, Rohanizadeh R; National Health and Medical Research Council (NHMRC)/Development Grants.

2013

  • A tight squeeze: Engineering anti-fibrotic depot aerosols that circumvent the epithelia; Young P, Traini D, Oliver B, Jarolimek W; Australian Research Council (ARC)/Linkage Projects (LP).
  • Drug - transporter - interactions in the lung and their implications for inhalation therapy; Ehrhardt C, Traini D; DVC Research/International Research Collaboration Award (IRCA).
  • WITEC Alpha 300R High Throughput Microscope - Confocal Raman Microscope; Traini D, Young P, Murray M, Dehghani F, Chan H, Oliver B, Holst J; DVC Research/Equipment Grant.
  • Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.
  • From ECR to Star! Establishment of an early career researcher network and workshop series that enhances collaboration and funding in the area of respiratory science; Traini D, Young P, Gaisford S; IPDF - Other/IPDF Contribution.

2012

  • Pandoras toolbox: the use of fluorosomes to formulate nanoparticle gene therapy for respiratory disease; Traini D; Australian Research Council (ARC)/Future Fellowships (FT).
  • Ultra-low dose dry powder inhaler technology for the treatment of respiratory diseases; Young P, Traini D, Fletcher D; Australian Research Council (ARC)/Linkage Projects (LP).
  • Treating tuberculosis: targeted delivery of multidrug nano-suspensions.; Traini D, Young P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Multi-drug dry powder inhalation systems for the effective treatment of chronic obstructive pulmonary disease; Young P, Stewart P, Traini D, Stewart P, Honnery D; Australian Research Council (ARC)/Discovery Projects (DP).

2011

  • Gulf-Australian Symposium: Breast Cancer current practice and future directions in imaging, medication formulation and safety and rehabilitation.; Brennan P, Refshauge K, Traini D; Council for Arab Australian Relations/Research Support.

2010

  • Engineering of composite particles to enhance performance in respiratory drug delivery; Traini D, Saunders M, Young P, Chan H; Australian Research Council (ARC)/Linkage Projects (LP).
  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Advanced Focused Ion Beam (FIB) / Scanning Electron Microscopes (SEM) for Nanometre Scale Characterisation and Fabrication; Cairney J, Munroe P, Ringer S, Ferry M, Mai Y, Liao X, McKenzie D, Wenham S, Dzurak A, Stevens-Kalceff M, Spinks G, Dou S, Valanoor N, Liu Z, Proust G, Young D, Braet F, Chan-Ling T, Maschmeyer T, Chan H, Traini D, Swain M, Harris A, Crawford J, Potts D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The effect of electrostatic charge on the plume of pressurised metered dose inhalers; Traini D, Lewis D, Young P, Chan H; Australian Research Council (ARC)/Linkage Projects (LP).
  • Particle interactions in non-aqueous liquids; Traini D; DVC Research/Bridging Support Grant.
  • Pulmonary delivery: deposition, fate, toxicology and effects - an in depth in vitro investigation of inhalation medicaments.; Bebawy M, Traini D; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Surface Energy Analyser (SEA); Traini D, Young P, Chan H, Rohanizadeh R, Bilek M, Langrish T, Gomes V; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Integrating nanomaterials in formulations (INFORM); Traini D; European Commission (Belgium)/Seventh Framework Network of Excellence Programme.
  • Development of an electrostatic apparatus for the evaluation of the charge distributions in aerosols for respiratory delivery; Traini D, Hoe S; GlaxoSmithKline Australia Pty Ltd/Scholarship.
  • A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation; Munroe P, Jones A, Zhou H, Cairney J, Einav I, Swain M, Murphy C, Seibel M, Ringer S, Li Q, Darendeliler M, Wang X, Zhang Y, Hand S, Archer M, Ramzan I, Young P, Traini D, Richardson D, Masters A, Milthorpe B; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Bruker APEX II CCD Detector Fourth Generation APEX II ultra-low noise CCD X-ray detector with 16 megapixel chip; Hibbs D, Roufogalis B, Murray M, Hambley T, Hanrahan J, Church W, Collins M, Johnston G, Young P, Traini D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Direct Measurements of Interparticulate Forces and Collodial Stability in Pressurised Systems; Traini D; DVC Research/Bridging Support Grant.
  • PSIA Thermal Atomic Force Microscope (AFM), XE-70 SPM system plus Scanning Thermal Microscope; Murray M, Chan H, Traini D; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2008

  • Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological Materials, and Medical Research; Bernard C, Marshall C, Wood B, Potts D, Penny D, Dutkiewicz A, Grau G, Sorrell T, Swain M, Yang W, Soon L, Lay P, McNaughton D, Maschmeyer T, Ramzan I, Beardall J, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials and Medical Research; Lay P, McNaughton D, Maschmeyer T, Potts D, Swain M, Grau G, Sorrell T, Ramzan I, Beardall J, Bernard C, Marshall C, Dutkiewicz A, Penny D, Wood B, Yang W, Soon L, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Engineering of co-crystal drug molecules for pharmaceutical aerosols; Young P, Traini D; Australian Research Council (ARC)/Discovery Projects (DP).
  • Nanoscale Thermal Imaging (SThM); Young P, Traini D, Yang W, Braet F, Chan H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • In vitro-In vivo toxicity investigation of biodegradable polymeric micro-particle for inhalation drug delivery; Sheedy S, Traini D; Clive and Vera Ramaciotti Foundations/Research Support.

2007

  • Novel co-processed synergistic antibiotics inhalation therapy for the twenty-first century; Traini D; Australian Academy of Science/Research Grants.
  • State of the art high resolution thermal analysis suite for the life and material sciences; Stewart P, Young P, Traini D, Chan H, Murray M, Dehghani F, Hibbs D, Larson I, Warr G, Weiss A; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Mannitol Powders for Assessment of Asthma in Children; Chan H, Young P, Crapper J, Traini D; Australian Research Council (ARC)/Linkage Projects (LP).
  • Formulation of controlled release aerosols for the treatment of lung infection; Traini D; University of Sydney/Early Career Researcher.
  • Engineering a delivery device and development of a novel formulation for chronic obstructive pulmonary disease and cystic fibrosis; Fletcher D, Crapper J, Young P, Chan H, Traini D; Australian Research Council (ARC)/Linkage Projects (LP).
  • Precision Titration/ Solution Calorimeter accessory for the Tam III Iosthermal calorimeter Calorimet; Chan H, Murray M, Hibbs D, Young P, Traini D, Weiss A, Stewart P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2006

  • Formulation Of Anti-Inflammatory Aerosols For The Treatment Of Pathogenic Lung Infection; Chan H, Traini D, Young P; Pharmacy Research Trust of NSW/Research Grants Program.

Selected publications

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Edited Books

  • Colombo, P., Traini, D., Buttini, F. (2013). Inhalation Drug Delivery: Techniques and Products. Chichester, UK: John Wiley & Sons.

Book Chapters

  • Traini, D., Young, P. (2013). Formulation of inhalation medicines. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 31-45). Chichester, UK: John Wiley & Sons.
  • Traini, D., Young, P. (2013). Inhalation and nasal products. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 15-30). Chichester, UK: John Wiley & Sons.
  • Traini, D. (2013). Inhalation drug delivery. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 1-14). Chichester, UK: John Wiley & Sons.
  • Young, P., Traini, D., Edge, S. (2008). Advances in Pulmonary Therapy. In Williams, Taft and McConville (Eds.), Advanced Drug Formulation Design to Optimize Therapeutic Outcome, (pp. 1-51). USA: Informa Healthcare.

Journals

  • Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
  • Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
  • Chan, J., Bai, X., Traini, D. (2014). An update on the use of rifapentine for tuberculosis therapy. Expert Opinion on Drug Delivery, 11(3), 421-431. [More Information]
  • Ong, H., Traini, D., Ballerin, G., Morgan, L., Buddle, L., Scalia, S., Young, P. (2014). Combined inhaled salbutamol and mannitol therapy for mucus hyper-secretion in pulmonary diseases. The AAPS Journal, 16(2), 269-280. [More Information]
  • Salama, R., Young, P., Traini, D. (2014). Concurrent oral and inhalation drug delivery using a dual formulation system: the use of oral theophylline carrier with combined inhalable budesonide and terbutaline. Drug Delivery and Translational Research, 4(3), 256-267. [More Information]
  • Ong, H., Benaouda, F., Traini, D., Cipolla, D., Gonda, I., Bebawy, M., Forbes, B., Young, P. (2014). In vitro and ex vivo methods predict the enhanced lung residence time of liposomal ciprofloxacin formulations for nebulisation. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 83-89. [More Information]
  • Niaz, M., Traini, D., Young, P., Ghadiri, M., Rohanizadeh, R. (2014). Investigation into physical-chemical variables affecting the manufacture and dissolution of wet-milled clarithromycin nanoparticles. Pharmaceutical Development and Technology, 19(8), 911-921. [More Information]
  • Ooi, J., Gaisford, S., Boyd, B., Young, P., Traini, D. (2014). Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems. International Journal of Pharmaceutics, 461(1-2), 301-309. [More Information]
  • Ooi, J., Gaisford, S., Boyd, B., Young, P., Traini, D. (2014). Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems. International Journal of Pharmaceutics, 461(1-2), 301-309. [More Information]
  • Young, P., Crapper, J., Gary, P., Sharma, K., Chan, H., Traini, D. (2014). Overcoming Dose Limitations Using the Orbital(®) Multi-Breath Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2), 138-147. [More Information]
  • Saadat, A., Zhu, B., Haghi, M., King, G., Colombo, G., Young, P., Traini, D. (2014). The formulation, chemical and physical characterisation of clarithromycin-based macrolide solution pressurised metered dose inhaler. Journal of Pharmacy and Pharmacology, 66(5). [More Information]
  • Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2014). The Influence of Actuator Materials and Nozzle Designs on Electrostatic Charge of Pressurised Metered Dose Inhaler (pMDI) Formulations. Pharmaceutical Research, 31(5), 1325-1337. [More Information]
  • Zhu, B., Traini, D., Lewis, D., Young, P. (2014). The solid-state and morphological characteristics of particles generated from solution-based metered dose inhalers: Influence of ethanol concentration and intrinsic drug properties. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 443, 345-355. [More Information]
  • Lewis, D., Young, P., Buttini, F., Church, T., Colombo, P., Forbes, B., Haghi, M., Johnson, R., O'Shea, H., Salama, R., Traini, D. (2014). Towards the bioequivalence of pressurised metered dose inhalers 1: Design and characterisation of aerodynamically equivalent beclomethasone dipropionate inhalers with and without glycerol as a non-volatile excipient. European Journal of Pharmaceutics and Biopharmaceutics, 86, 31-37. [More Information]
  • Haghi, M., Bebawy, M., Colombo, P., Forbes, B., Lewis, D., Salama, R., Traini, D., Young, P. (2014). Towards the bioequivalence of pressurised metered dose inhalers 2. Aerodynamically equivalent particles (with and without glycerol) exhibit different biopharmaceutical profiles in vitro. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 38-45. [More Information]
  • Chan, J., Chan, H., Prestidge, C., Denman, J., Young, P., Traini, D. (2013). A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 285-292. [More Information]
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2013). Ciprofloxacin Is Actively Transported across Bronchial Lung Epithelial Cells Using a Calu-3 Air Interface Cell Model. Antimicrobial Agents and Chemotherapy, 57(6), 2535-2540. [More Information]
  • Scalia, S., Traini, D., Young, P., Di Sabatino, M., Passerini, N., Albertini, B. (2013). Comparison of spray congealing and melt emulsification methods for the incorporation of the water-soluble salbutamol sulphate in lipid microparticles. Pharmaceutical Development and Technology, 18(1), 266-273. [More Information]
  • Haghi, M., Traini, D., Postma, D., Bebawy, M., Young, P. (2013). Fluticasone uptake across Calu-3 cells is mediated by salmeterol when deposited as a combination powder inhaler. Respirology, 18(8), 1197-1201. [More Information]
  • Scalia, S., Trotta, V., Traini, D., Young, P., Sticozzi, C., Cervellati, F., Valacchi, G. (2013). Incorporation of quercetin in respirable lipid microparticles: Effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells. Colloids And Surfaces B: Biointerfaces, 112, 322-329. [More Information]
  • Marin, L., Traini, D., Bebawy, M., Colombo, P., Buttini, F., Haghi, M., Ong, H., Young, P. (2013). Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: Implications in the treatment of chronic obstructive airway pathologies. European Journal of Pharmaceutics and Biopharmaceutics, 84(3), 566-572. [More Information]
  • Ong, H., Traini, D., Young, P. (2013). Pharmaceutical applications of the Calu-3 lung epithelia cell line. Expert Opinion on Drug Delivery, 10(9), 1287-1302. [More Information]
  • Scalia, S., Haghi, M., Losi, V., Trotta, V., Young, P., Traini, D. (2013). Quercetin solid lipid microparticles: A flavonoid for inhalation lung delivery. European Journal of Pharmaceutical Sciences, 49(2), 278-285. [More Information]
  • Mamlouk, M., Young, P., Bebawy, M., Haghi, M., Mamlouk, S., Mulay, V., Traini, D. (2013). Salbutamol Sulfate Absorption Across Calu-3 Bronchial Epithelia Cell Monolayer is Inhibited in the Presence of Common Anionic NSAIDs. Journal of Asthma, 50(4), 334-341. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug Development and Industrial Pharmacy, 39(11), 1625-1637. [More Information]
  • Ong, H., Traini, D., Salama, R., Anderson, S., Daviskas, E., Young, P. (2013). The Effects of Mannitol on the Transport of Ciprofloxacin across Respiratory Epithelia. Molecular Pharmaceutics, 10(8), 2915-2924. [More Information]
  • Adi, H., Young, P., Traini, D. (2012). Co-deposition of a triple therapy drug formulation for the treatment of chronic obstructive pulmonary disease using solution-based pressurised metered dose inhalers. Journal of Pharmacy and Pharmacology, 64(9), 1245-1253. [More Information]
  • Chan, J., Traini, D., Chan, H., Young, P., Kwok, P. (2012). Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(5), 297-305. [More Information]
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2012). Deposition, Diffusion and Transport Mechanism of Dry Powder Microparticulate Salbutamol, at the Respiratory Epithelia. Molecular Pharmaceutics, 9(6), 1717-1726. [More Information]
  • Ong, H., Traini, D., Cipolla, D., Gonda, I., Bebawy, M., Agus, H., Young, P. (2012). Liposomal Nanoparticles Control the Uptake of Ciprofloxacin Across Respiratory Epithelia. Pharmaceutical Research, 29(12), 3335-3346. [More Information]
  • Upadhyay, D., Scalia, S., Vogel, R., Wheate, N., Salama, R., Young, P., Traini, D., Chrzanowski, W. (2012). Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery. Pharmaceutical Research, 29(9), 2456-2467. [More Information]
  • Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D. (2012). Micronized drug powders in binary mixtures and the effect of physical properties on aerosolization from combination drug dry powder inhalers. Drug Development and Industrial Pharmacy, 38(12), 1504-1511. [More Information]
  • Haghi, M., Salama, R., Traini, D., Bebawy, M., Young, P. (2012). Modification of Disodium Cromoglycate Passage Across Lung Epithelium In Vitro Via Incorporation into Polymeric Microparticles. The AAPS Journal, 14(1), 79-86. [More Information]
  • Traini, D., Scalia, S., Adi, H., Marangoni, E., Young, P. (2012). Polymer coating of carrier excipients modify aerosol performance of adhered drugs used in dry powder inhalation therapy. International Journal of Pharmaceutics, 438(1-2), 150-159. [More Information]
  • Traini, D., Adi, H., Valet, O., Young, P. (2012). Preparation and Evaluation of Single and Co-Engineered Combination Inhalation Carrier Formulations for the Treatment of Asthma. Journal of Pharmaceutical Sciences, 101(11), 4267-4276. [More Information]
  • Scalia, S., Salama, R., Young, P., Traini, D. (2012). Preparation and in vitro evaluation of salbutamol-loaded lipid microparticles for sustained release pulmonary therapy. Journal of Microencapsulation, 29(3), 225-233. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Young, P. (2012). The use of computational approaches in inhaler development. Advanced Drug Delivery Reviews, 64(4), 312-322. [More Information]
  • Jones, M., Young, P., Traini, D. (2012). The use of inverse gas chromatography for the study of lactose and pharmaceutical materials used in dry powder inhalers. Advanced Drug Delivery Reviews, 64(3), 285-293. [More Information]
  • Rogueda, P., Lallement, A., Traini, D., Iliev, I., Young, P. (2012). Twenty years of HFA pMDI patents: facts and perspectives. Journal of Pharmacy and Pharmacology, 64(9), 1209-1216. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). A Review of Electrostatic Measurement Techniques for Aerosol Drug Delivery to the Lung: Implications in Aerosol Particle Deposition. Journal of Adhesion Science and Technology, 25(4-5), 385-405. [More Information]
  • Salama, R., Young, P., Rogueda, P., Lallement, A., Iliev, I., Traini, D. (2011). Advances in drug delivery: is triple therapy the future for the treatment of chronic obstructive pulmonary disease? Expert Opinion on Pharmacotherapy, 12(12), 1913-1932. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). Aerosol tribocharging and its relation to the deposition of Oxis Turbuhaler in the electrical next generation impactor. Journal of Pharmaceutical Sciences, 100(12), 5270-5280. [More Information]
  • Marin, L., Colombo, P., Bebawy, M., Young, P., Traini, D. (2011). Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management. Expert Opinion on Drug Delivery, 8(9), 1205-1220. [More Information]
  • Ooi, J., Traini, D., Hoe, S., Wong, W., Young, P. (2011). Does carrier size matter? A fundamental study of drug aerosolisation from carrier based dry powder inhalation systems. International Journal of Pharmaceutics, 413(1-2 (Feb)), 1-9. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). Dynamic electrostatic charge of lactose-salbutamol sulphate powder blends dispersed from a Cyclohaler. Drug Development and Industrial Pharmacy, 37(11), 1365-1375. [More Information]
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2011). Epithelial Profiling of Antibiotic Controlled Release Respiratory Formulations. Pharmaceutical Research, 28(9), 2327-2338. [More Information]
  • Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
  • Abdel-Halim, H., Traini, D., Hibbs, D., Gaisford, S., Young, P. (2011). Modelling of molecular phase transitions in pharmaceutical inhalation compounds: an in silico approach. European Journal of Pharmaceutics and Biopharmaceutics, 78(1), 83-89. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-Up in Dry Powder Inhalers: Evaluation and Modelling of Impaction Effects for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(7), 2744-2754. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-up in Dry Powder Inhalers: Evaluation and Modelling of the Influence of Grid Structures for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(11), 4710-4721. [More Information]
  • Rogueda, P., Price, R., Smith, T., Young, P., Traini, D. (2011). Particle synergy and aerosol performance in non-aqueous liquid of two combinations metered dose inhalation formulations: an AFM and Raman investigation. Journal of Colloid and Interface Science, 361(2), 649-655. [More Information]
  • Young, P., Wood, O., Ooi, J., Traini, D. (2011). The influence of drug loading on formulation structure and aerosol performance in carrier based dry powder inhalers. International Journal of Pharmaceutics, 416(1), 129-135. [More Information]
  • Strusi, O., Barata, P., Traini, D., Young, P., Mercuri, S., Colombo, G., Sonvico, F., Bettini, R., Colombo, P. (2010). Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products. Journal of Controlled Release, 146(1), 54-60. [More Information]
  • Adi, H., Young, P., Chan, H., Agus, H., Traini, D. (2010). Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European Journal of Pharmaceutical Sciences, 40, 239-247. [More Information]
  • Adi, H., Young, P., Chan, H., Salama, R., Traini, D. (2010). Controlled release antibiotics for dry powder lung delivery. Drug Development and Industrial Pharmacy, 36(1), 119-126. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2010). Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems. Pharmaceutical Research, 27(7), 1367-1376. [More Information]
  • Wong, W., Crapper, J., Chan, H., Traini, D., Young, P. (2010). Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of Pharmaceutical and Biomedical Analysis, 51(4), 853-857. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2010). The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems. Pharmaceutical Research, 27(7), 1325-1336. [More Information]
  • Haghi, M., Young, P., Traini, D., Jaiswal, R., Gong, J., Bebawy, M. (2010). Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model. Drug Development and Industrial Pharmacy, 36(10), 1207-1214. [More Information]
  • Traini, D., Young, P. (2009). Delivery of antibiotics to the respiratory tract: an update. Expert Opinion on Drug Delivery, 6(9), 897-905. [More Information]
  • Salama, R., Ladd, L., Chan, H., Traini, D., Young, P. (2009). Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. The AAPS Journal, 11(3), 465-468. [More Information]
  • Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Introduction of the Electrical Next Generation Impactor (eNGI) and Investigation of its Capabilities for the Study of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 26(2), 431-437. [More Information]
  • Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences, 38, 88-94. [More Information]
  • Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
  • Parlati, C., Colombo, P., Buttini, F., Young, P., Adi, H., Ammit, A., Traini, D. (2009). Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency. Pharmaceutical Research, 26(5), 1084-1092. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2009). Recent Advances in Controlled Release Pulmonary Therapy. Current Drug Delivery, 6(4), 404-414. [More Information]
  • Mezzena, M., Scalia, S., Young, P., Traini, D. (2009). Solid Lipid Budesonide Microparticles for Controlled Release Inhalation Therapy. The AAPS Journal, 11(4), 771-778. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers. Pharmaceutical Research, 26(12), 2639-2646. [More Information]
  • Young, P., Adi, H., Patel, T., Law, K., Rogueda, P., Traini, D. (2009). The influence of micronised particulates on the aerosolisation properties of pressurised metered dose inhalers. Journal of Aerosol Science, 40, 324-337. [More Information]
  • Young, P., Roberts, D., Chiou, H., Rae, W., Chan, H., Traini, D. (2008). Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science, 39, 82-93. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2008). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, 97(8), 3356-3366. [More Information]
  • Hoe, S., Young, P., Rogueda, P., Traini, D. (2008). Determination of reference ultrasound parameters for model and hydrofluoroalkane propellants using high-resolution ultrasonic spectroscopy. AAPS PharmSciTech, 9(2), 605-611. [More Information]
  • Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information]
  • Young, P., Nguyen, K., Jones, A., Traini, D. (2008). Microstructural Analysis of Porous Composite Materials: Dynamic Imaging of Drug Dissolution and Diffusion Through Porous Matrices. The AAPS Journal, DOI: 10.1208/s12248-008-9063-2(Print version 2008 Vol. 10 pp. 560-564), 1-5. [More Information]
  • Salama, R., Hoe, S., Chan, H., Traini, D., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 486-495. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 145-152. [More Information]
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2008). Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences, 97(8), 3140-3152.
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D., Yang, R., Yu, A. (2008). Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir, 24(19), 11307-11312. [More Information]
  • Traini, D., Young, P., Thielmann, F., Acharya, M. (2008). The influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulations. Drug Development and Industrial Pharmacy, 34(9), 992-1001. [More Information]
  • Jones, M., Young, P., Traini, D., Shur, J., Edge, S., Price, R. (2008). The use of atomic force microscopy to study the conditioning of micronised budesonide. International Journal of Pharmaceutics, 357(1-2), 314-317. [More Information]
  • Traini, D., Loreti, G., Jones, A., Young, P. (2008). X-Ray Computed Microtomography for the Study of Modified Release Systems. Microscopy and Analysis, 22(1), 13-15.
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2007). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, online(DOI 10.1002/jps.21239), 1-11. [More Information]
  • Chan, H., Young, P., Traini, D., Coates, M. (2007). Dry powder inhalers: challenges and goals for next generation therapies. Pharmaceutical Technology Europe, 19(4), 19-24.
  • Young, P., Edge, S., Staniforth, J., Steele, D., Traini, D., Price, R. (2007). Effect of Moisture on the Compressibility and Compactibility of Sodium Starch Glycolate. Pharmaceutical Development and Technology, 12(2), 217-222.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2007). In Vitro Investigation of Drug Particulates Interactions and Aerosol Performance of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 24(1), 125-135. [More Information]
  • Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
  • Young, P., Traini, D., Coates, M., Chan, H. (2007). Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, 394(2), 315-319.
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2007). Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences, 97(8), 3140-3152. [More Information]
  • Adi, H., Traini, D., Chan, H., Young, P. (2007). The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Sciences, Published online DOI 10.1002/jps.21195(Print version 2008 VOL. 97, NO. 7), 2780-2788. [More Information]
  • Young, P., Chan, H., Chiou, H., Edge, S., Tee, H., Traini, D. (2007). The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of Pharmaceutical Sciences, 96(5), 1331-1341. [More Information]
  • Rogueda, P., Traini, D. (2007). The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects. Expert Opinion on Drug Delivery, 4(6), 595-606. [More Information]
  • Rogueda, P., Traini, D. (2007). The nanoscale in pulmonary delivery. Part 2: formulation platforms. Expert Opinion on Drug Delivery, 4(6), 607-620. [More Information]
  • Young, P., Chiou, H., Tee, H., Traini, D., Chan, H., Thielmann, F., Burnett, D. (2007). The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, 33(1), 91-97. [More Information]
  • Traini, D., Young, P., Price, R., Rogueda, P. (2006). A novel apparatus for the determination of solubility in pressurized metered dose inhalers. Drug Development and Industrial Pharmacy, 32(10), 1159-1163. [More Information]
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2006). Agglomerate Strength and Dispersion of Salmeterol Xinafoate from Powder Mixtures for Inhalation. Pharmaceutical Research, 23(11), 2556-2565. [More Information]
  • Traini, D., Young, P., Jones, M., Edge, S., Price, R. (2006). Comparative study of erythritol and lactose monohydrate as carriers for inhalation: atomic force microscopy and in vitro correlation. European Journal of Pharmaceutical Sciences, 27(2-3), 243-251. [More Information]
  • Traini, D., Young, P., Rogueda, P., Price, R. (2006). Investigation into the influence of polymeric stabilizing excipients on inter-particulate forces in pressurised metered dose inhalers. International Journal of Pharmaceutics, 320(1-2), 58-63. [More Information]
  • Traini, D., Young, P., Rogueda, P., Price, R. (2006). The use of AFM and surface energy measurements to investigate drug-canister material interactions in a model pressurized metered dose inhaler formulation. Aerosol Science and Technology, 40(4), 227-236.
  • Traini, D., Rogueda, P., Young, P., Price, R. (2005). Surface Energy and Interparticle Force Correlation in Model pMDI Formulations. Pharmaceutical Research, 22(5), 816-825. [More Information]
  • Traini, D., Rogueda, P., Young, P., Price, R. (2005). Surface energy and interparticle forces correlations in model pMDI formulations. Pharmaceutical Research, 22(5), 816-25. [More Information]
  • Young, P., Edge, S., Traini, D., Jones, M., Price, R., El-Sabawi, D., Urry, C., Smith, C. (2005). The influence of dose on the performance of dry powder inhalation systems. International Journal of Pharmaceutics, 296(1-2), 26-33. [More Information]
  • Young, P., Price, R., Lewis, D., Edge, S., Traini, D. (2003). Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope. Journal of Colloid and Interface Science, 262(1), 298-302.

Conferences

  • Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of glycerol on the formation and morphology of particles generated from budesonide solution-based pressurized metered dose inhalers. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Chen, Y., Traini, D., Fletcher, D., Chan, H., Lewis, D., Church, T., Young, P. (2013). The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2013). Uptake of salmeterol xinafoate and fluticasone propionate from single and combination dry powder inhalers after deposition on calu-3 respiratory epithelia. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Chan, J., Chan, H., Young, P., Traini, D. (2012). An Inhaled Triple Antibiotic Dry Powder Formulation for the Treatment of Tuberculosis. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Ong, H., Cipolla, D., Gonda, I., Traini, D., Bebawy, M., Agus, H., Young, P. (2012). Inhaled Liposomal Ciprofloxacin Nanoparticles Control the Release of Antibiotic at the Bronchial Epithelia. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Chen, Y., Wong, W., Lewis, D., Church, T., Traini, D., Young, P. (2012). Triboelectrification Study of a Pressurized Metered Dose Inhaler (pMDI) Formulation Using Different Actuator Materials and Orifice Designs. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2011). Cellular Release Profiling of Controlled Release Dry Powder Pulmonary Formulations. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2011). Comparison of Albuterol Sulphate and Base Dry Powder Particulate Deposition Using the Calu-3 Lung Epithelial Model. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Jetmalani, K., Stewart, P., Traini, D., Young, P. (2011). Formulation and Characteristics of Combination Dry Powder Inhalation Therapy. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Young, P., Traini, D., Salama, R. (2011). In Vitro Techniques Equipped to Study Clinically Relevant Controlled Release Products. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D. (2011). Micronized drug powders in binary mixtures and the effect of physical properties on aerosolisation from combination drug dry powder inhalers. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Marin, L., Colombo, P., Buttini, F., Bebawy, M., Young, P., Traini, D. (2011). Multiple-dosing of Simvastatin Inhibits Mucus Production on the Calu-3 air interface cell model. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Traini, D., Young, P. (2011). Novel approaches to treating respiratory infection using antibiotic DPI systems. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Haghi, M., Young, P., Traini, D., Bebawy, M. (2010). Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Valet, O., Lankers, M., Adi, H., Traini, D., Young, P. (2010). The Use of High Throughput Raman Microscopy for the Concurrent Size Determination and Chemical Characterization of Inhalation Particles. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Wong, W., Adi, H., Traini, D., Chan, H., Fletcher, D., Crapper, J., Young, P. (2010). Use of Rapid Prototyping and Computational Fluid Dynamics in the Design of DPI Devices. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Application of the Electrical Next Generation Impactor (eNGI) for the Electrostatic Characterization of Commercial Dry Powder Inhaler Formulations. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Wong, W., Traini, D., Chan, H., Crapper, J., Young, P. (2009). High Dose Respiratory Medicines: Pharmacopeia Methodologies for Determining Aerodynamic Mass Distributions. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2008). Electrical Next Generation Impactor (eNGI): A New Method for Aerosol Electrostatics. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Salama, R., Ladd, L., Traini, D., Chan, H., Young, P. (2008). Formulation, Characterization and In Vitro - In Vivo Evaluation of Spray Dried Pulmonary Microparticles in an Ovine Animal Model. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Parlati, C., Adi, H., Buttini, F., Colombo, P., Young, P., Traini, D. (2008). In Vitro Evaluation of Co-Processed Antibiotic for Inhalation. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Traini, D. (2008). Predicting Adhesion and Cohesion in Non-Aqueous Propellant Systems - Theory Versus Practice. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D. (2008). Use of Scanning White Light Interferometry to Evaluate the Surface Roughness and Aerosol Performance of Spherical Micron-Sized Drug Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, H., Young, P., Chan, H., Traini, D., Stewart, P. (2007). Cospray dried antibiotics for dry powder inhalation delivery. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing. [More Information]
  • Young, P., Adi, H., Stewart, P., Traini, D. (2006). Effect of modification of lactose on its surface energy characteristics. Australasian Pharmaceutical Science Association (APSA).
  • Young, P., Naderi, M., Traini, D., Thielmann, F. (2006). Impact of Lactose Polymorphism on Salbutamol Sulphate Lactose Interactions in DPI Formulations. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., Salama, R., Chan, H., Traini, D. (2006). Preparation and characterisation of controlled release microparticles for inhalation. Australasian Pharmaceutical Science Association (APSA).
  • Traini, D., Tee, H., Chiou, H., Chan, H., Young, P. (2006). The Effect of Mechanically Processed Pharmaceutical Carries for Dry Powder Inhalation on Drug Aerosolisation Performance. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Young, P., Chiou, H., Tee, E., Traini, D., Theilmann, F., Chan, H. (2006). The uses of a novel dynamic vapour sorption method to calculate low levels of amorphous content in lactose samples for dry powder inhaler formulations. Australasian Pharmaceutical Science Association (APSA).
  • Young, P., Price, A., Traini, D. (2005). Coarse carriers, active sites and sticky drugs. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2005). Investigating particle interactions in non-aqueous model suspensions by surface energy and AFM measurements. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2005). The use of in vitro, AFM and surface energy measurements to predict pMDI aerosolisation performance. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2004). Study of particle adhesion to polymer coated pMDI canister walls: surface energy and AFM measurements. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.

2014

  • Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
  • Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
  • Chan, J., Bai, X., Traini, D. (2014). An update on the use of rifapentine for tuberculosis therapy. Expert Opinion on Drug Delivery, 11(3), 421-431. [More Information]
  • Ong, H., Traini, D., Ballerin, G., Morgan, L., Buddle, L., Scalia, S., Young, P. (2014). Combined inhaled salbutamol and mannitol therapy for mucus hyper-secretion in pulmonary diseases. The AAPS Journal, 16(2), 269-280. [More Information]
  • Salama, R., Young, P., Traini, D. (2014). Concurrent oral and inhalation drug delivery using a dual formulation system: the use of oral theophylline carrier with combined inhalable budesonide and terbutaline. Drug Delivery and Translational Research, 4(3), 256-267. [More Information]
  • Ong, H., Benaouda, F., Traini, D., Cipolla, D., Gonda, I., Bebawy, M., Forbes, B., Young, P. (2014). In vitro and ex vivo methods predict the enhanced lung residence time of liposomal ciprofloxacin formulations for nebulisation. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 83-89. [More Information]
  • Niaz, M., Traini, D., Young, P., Ghadiri, M., Rohanizadeh, R. (2014). Investigation into physical-chemical variables affecting the manufacture and dissolution of wet-milled clarithromycin nanoparticles. Pharmaceutical Development and Technology, 19(8), 911-921. [More Information]
  • Ooi, J., Gaisford, S., Boyd, B., Young, P., Traini, D. (2014). Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems. International Journal of Pharmaceutics, 461(1-2), 301-309. [More Information]
  • Ooi, J., Gaisford, S., Boyd, B., Young, P., Traini, D. (2014). Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems. International Journal of Pharmaceutics, 461(1-2), 301-309. [More Information]
  • Young, P., Crapper, J., Gary, P., Sharma, K., Chan, H., Traini, D. (2014). Overcoming Dose Limitations Using the Orbital(®) Multi-Breath Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2), 138-147. [More Information]
  • Saadat, A., Zhu, B., Haghi, M., King, G., Colombo, G., Young, P., Traini, D. (2014). The formulation, chemical and physical characterisation of clarithromycin-based macrolide solution pressurised metered dose inhaler. Journal of Pharmacy and Pharmacology, 66(5). [More Information]
  • Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2014). The Influence of Actuator Materials and Nozzle Designs on Electrostatic Charge of Pressurised Metered Dose Inhaler (pMDI) Formulations. Pharmaceutical Research, 31(5), 1325-1337. [More Information]
  • Zhu, B., Traini, D., Lewis, D., Young, P. (2014). The solid-state and morphological characteristics of particles generated from solution-based metered dose inhalers: Influence of ethanol concentration and intrinsic drug properties. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 443, 345-355. [More Information]
  • Lewis, D., Young, P., Buttini, F., Church, T., Colombo, P., Forbes, B., Haghi, M., Johnson, R., O'Shea, H., Salama, R., Traini, D. (2014). Towards the bioequivalence of pressurised metered dose inhalers 1: Design and characterisation of aerodynamically equivalent beclomethasone dipropionate inhalers with and without glycerol as a non-volatile excipient. European Journal of Pharmaceutics and Biopharmaceutics, 86, 31-37. [More Information]
  • Haghi, M., Bebawy, M., Colombo, P., Forbes, B., Lewis, D., Salama, R., Traini, D., Young, P. (2014). Towards the bioequivalence of pressurised metered dose inhalers 2. Aerodynamically equivalent particles (with and without glycerol) exhibit different biopharmaceutical profiles in vitro. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 38-45. [More Information]

2013

  • Chan, J., Chan, H., Prestidge, C., Denman, J., Young, P., Traini, D. (2013). A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 285-292. [More Information]
  • Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2013). Ciprofloxacin Is Actively Transported across Bronchial Lung Epithelial Cells Using a Calu-3 Air Interface Cell Model. Antimicrobial Agents and Chemotherapy, 57(6), 2535-2540. [More Information]
  • Scalia, S., Traini, D., Young, P., Di Sabatino, M., Passerini, N., Albertini, B. (2013). Comparison of spray congealing and melt emulsification methods for the incorporation of the water-soluble salbutamol sulphate in lipid microparticles. Pharmaceutical Development and Technology, 18(1), 266-273. [More Information]
  • Haghi, M., Traini, D., Postma, D., Bebawy, M., Young, P. (2013). Fluticasone uptake across Calu-3 cells is mediated by salmeterol when deposited as a combination powder inhaler. Respirology, 18(8), 1197-1201. [More Information]
  • Traini, D., Young, P. (2013). Formulation of inhalation medicines. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 31-45). Chichester, UK: John Wiley & Sons.
  • Scalia, S., Trotta, V., Traini, D., Young, P., Sticozzi, C., Cervellati, F., Valacchi, G. (2013). Incorporation of quercetin in respirable lipid microparticles: Effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells. Colloids And Surfaces B: Biointerfaces, 112, 322-329. [More Information]
  • Traini, D., Young, P. (2013). Inhalation and nasal products. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 15-30). Chichester, UK: John Wiley & Sons.
  • Traini, D. (2013). Inhalation drug delivery. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 1-14). Chichester, UK: John Wiley & Sons.
  • Colombo, P., Traini, D., Buttini, F. (2013). Inhalation Drug Delivery: Techniques and Products. Chichester, UK: John Wiley & Sons.
  • Marin, L., Traini, D., Bebawy, M., Colombo, P., Buttini, F., Haghi, M., Ong, H., Young, P. (2013). Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: Implications in the treatment of chronic obstructive airway pathologies. European Journal of Pharmaceutics and Biopharmaceutics, 84(3), 566-572. [More Information]
  • Ong, H., Traini, D., Young, P. (2013). Pharmaceutical applications of the Calu-3 lung epithelia cell line. Expert Opinion on Drug Delivery, 10(9), 1287-1302. [More Information]
  • Scalia, S., Haghi, M., Losi, V., Trotta, V., Young, P., Traini, D. (2013). Quercetin solid lipid microparticles: A flavonoid for inhalation lung delivery. European Journal of Pharmaceutical Sciences, 49(2), 278-285. [More Information]
  • Mamlouk, M., Young, P., Bebawy, M., Haghi, M., Mamlouk, S., Mulay, V., Traini, D. (2013). Salbutamol Sulfate Absorption Across Calu-3 Bronchial Epithelia Cell Monolayer is Inhibited in the Presence of Common Anionic NSAIDs. Journal of Asthma, 50(4), 334-341. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug Development and Industrial Pharmacy, 39(11), 1625-1637. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of glycerol on the formation and morphology of particles generated from budesonide solution-based pressurized metered dose inhalers. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Chen, Y., Traini, D., Fletcher, D., Chan, H., Lewis, D., Church, T., Young, P. (2013). The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Ong, H., Traini, D., Salama, R., Anderson, S., Daviskas, E., Young, P. (2013). The Effects of Mannitol on the Transport of Ciprofloxacin across Respiratory Epithelia. Molecular Pharmaceutics, 10(8), 2915-2924. [More Information]
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2013). Uptake of salmeterol xinafoate and fluticasone propionate from single and combination dry powder inhalers after deposition on calu-3 respiratory epithelia. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.

2012

  • Chan, J., Chan, H., Young, P., Traini, D. (2012). An Inhaled Triple Antibiotic Dry Powder Formulation for the Treatment of Tuberculosis. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Adi, H., Young, P., Traini, D. (2012). Co-deposition of a triple therapy drug formulation for the treatment of chronic obstructive pulmonary disease using solution-based pressurised metered dose inhalers. Journal of Pharmacy and Pharmacology, 64(9), 1245-1253. [More Information]
  • Chan, J., Traini, D., Chan, H., Young, P., Kwok, P. (2012). Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(5), 297-305. [More Information]
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2012). Deposition, Diffusion and Transport Mechanism of Dry Powder Microparticulate Salbutamol, at the Respiratory Epithelia. Molecular Pharmaceutics, 9(6), 1717-1726. [More Information]
  • Ong, H., Cipolla, D., Gonda, I., Traini, D., Bebawy, M., Agus, H., Young, P. (2012). Inhaled Liposomal Ciprofloxacin Nanoparticles Control the Release of Antibiotic at the Bronchial Epithelia. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Ong, H., Traini, D., Cipolla, D., Gonda, I., Bebawy, M., Agus, H., Young, P. (2012). Liposomal Nanoparticles Control the Uptake of Ciprofloxacin Across Respiratory Epithelia. Pharmaceutical Research, 29(12), 3335-3346. [More Information]
  • Upadhyay, D., Scalia, S., Vogel, R., Wheate, N., Salama, R., Young, P., Traini, D., Chrzanowski, W. (2012). Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery. Pharmaceutical Research, 29(9), 2456-2467. [More Information]
  • Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D. (2012). Micronized drug powders in binary mixtures and the effect of physical properties on aerosolization from combination drug dry powder inhalers. Drug Development and Industrial Pharmacy, 38(12), 1504-1511. [More Information]
  • Haghi, M., Salama, R., Traini, D., Bebawy, M., Young, P. (2012). Modification of Disodium Cromoglycate Passage Across Lung Epithelium In Vitro Via Incorporation into Polymeric Microparticles. The AAPS Journal, 14(1), 79-86. [More Information]
  • Traini, D., Scalia, S., Adi, H., Marangoni, E., Young, P. (2012). Polymer coating of carrier excipients modify aerosol performance of adhered drugs used in dry powder inhalation therapy. International Journal of Pharmaceutics, 438(1-2), 150-159. [More Information]
  • Traini, D., Adi, H., Valet, O., Young, P. (2012). Preparation and Evaluation of Single and Co-Engineered Combination Inhalation Carrier Formulations for the Treatment of Asthma. Journal of Pharmaceutical Sciences, 101(11), 4267-4276. [More Information]
  • Scalia, S., Salama, R., Young, P., Traini, D. (2012). Preparation and in vitro evaluation of salbutamol-loaded lipid microparticles for sustained release pulmonary therapy. Journal of Microencapsulation, 29(3), 225-233. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Young, P. (2012). The use of computational approaches in inhaler development. Advanced Drug Delivery Reviews, 64(4), 312-322. [More Information]
  • Jones, M., Young, P., Traini, D. (2012). The use of inverse gas chromatography for the study of lactose and pharmaceutical materials used in dry powder inhalers. Advanced Drug Delivery Reviews, 64(3), 285-293. [More Information]
  • Chen, Y., Wong, W., Lewis, D., Church, T., Traini, D., Young, P. (2012). Triboelectrification Study of a Pressurized Metered Dose Inhaler (pMDI) Formulation Using Different Actuator Materials and Orifice Designs. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Rogueda, P., Lallement, A., Traini, D., Iliev, I., Young, P. (2012). Twenty years of HFA pMDI patents: facts and perspectives. Journal of Pharmacy and Pharmacology, 64(9), 1209-1216. [More Information]

2011

  • Hoe, S., Young, P., Traini, D. (2011). A Review of Electrostatic Measurement Techniques for Aerosol Drug Delivery to the Lung: Implications in Aerosol Particle Deposition. Journal of Adhesion Science and Technology, 25(4-5), 385-405. [More Information]
  • Salama, R., Young, P., Rogueda, P., Lallement, A., Iliev, I., Traini, D. (2011). Advances in drug delivery: is triple therapy the future for the treatment of chronic obstructive pulmonary disease? Expert Opinion on Pharmacotherapy, 12(12), 1913-1932. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). Aerosol tribocharging and its relation to the deposition of Oxis Turbuhaler in the electrical next generation impactor. Journal of Pharmaceutical Sciences, 100(12), 5270-5280. [More Information]
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2011). Cellular Release Profiling of Controlled Release Dry Powder Pulmonary Formulations. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Marin, L., Colombo, P., Bebawy, M., Young, P., Traini, D. (2011). Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management. Expert Opinion on Drug Delivery, 8(9), 1205-1220. [More Information]
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2011). Comparison of Albuterol Sulphate and Base Dry Powder Particulate Deposition Using the Calu-3 Lung Epithelial Model. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Ooi, J., Traini, D., Hoe, S., Wong, W., Young, P. (2011). Does carrier size matter? A fundamental study of drug aerosolisation from carrier based dry powder inhalation systems. International Journal of Pharmaceutics, 413(1-2 (Feb)), 1-9. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). Dynamic electrostatic charge of lactose-salbutamol sulphate powder blends dispersed from a Cyclohaler. Drug Development and Industrial Pharmacy, 37(11), 1365-1375. [More Information]
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2011). Epithelial Profiling of Antibiotic Controlled Release Respiratory Formulations. Pharmaceutical Research, 28(9), 2327-2338. [More Information]
  • Jetmalani, K., Stewart, P., Traini, D., Young, P. (2011). Formulation and Characteristics of Combination Dry Powder Inhalation Therapy. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Young, P., Traini, D., Salama, R. (2011). In Vitro Techniques Equipped to Study Clinically Relevant Controlled Release Products. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
  • Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D. (2011). Micronized drug powders in binary mixtures and the effect of physical properties on aerosolisation from combination drug dry powder inhalers. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Abdel-Halim, H., Traini, D., Hibbs, D., Gaisford, S., Young, P. (2011). Modelling of molecular phase transitions in pharmaceutical inhalation compounds: an in silico approach. European Journal of Pharmaceutics and Biopharmaceutics, 78(1), 83-89. [More Information]
  • Marin, L., Colombo, P., Buttini, F., Bebawy, M., Young, P., Traini, D. (2011). Multiple-dosing of Simvastatin Inhibits Mucus Production on the Calu-3 air interface cell model. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Traini, D., Young, P. (2011). Novel approaches to treating respiratory infection using antibiotic DPI systems. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-Up in Dry Powder Inhalers: Evaluation and Modelling of Impaction Effects for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(7), 2744-2754. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-up in Dry Powder Inhalers: Evaluation and Modelling of the Influence of Grid Structures for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(11), 4710-4721. [More Information]
  • Rogueda, P., Price, R., Smith, T., Young, P., Traini, D. (2011). Particle synergy and aerosol performance in non-aqueous liquid of two combinations metered dose inhalation formulations: an AFM and Raman investigation. Journal of Colloid and Interface Science, 361(2), 649-655. [More Information]
  • Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Young, P., Wood, O., Ooi, J., Traini, D. (2011). The influence of drug loading on formulation structure and aerosol performance in carrier based dry powder inhalers. International Journal of Pharmaceutics, 416(1), 129-135. [More Information]

2010

  • Strusi, O., Barata, P., Traini, D., Young, P., Mercuri, S., Colombo, G., Sonvico, F., Bettini, R., Colombo, P. (2010). Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products. Journal of Controlled Release, 146(1), 54-60. [More Information]
  • Haghi, M., Young, P., Traini, D., Bebawy, M. (2010). Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Adi, H., Young, P., Chan, H., Agus, H., Traini, D. (2010). Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European Journal of Pharmaceutical Sciences, 40, 239-247. [More Information]
  • Adi, H., Young, P., Chan, H., Salama, R., Traini, D. (2010). Controlled release antibiotics for dry powder lung delivery. Drug Development and Industrial Pharmacy, 36(1), 119-126. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2010). Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems. Pharmaceutical Research, 27(7), 1367-1376. [More Information]
  • Wong, W., Crapper, J., Chan, H., Traini, D., Young, P. (2010). Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of Pharmaceutical and Biomedical Analysis, 51(4), 853-857. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2010). The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems. Pharmaceutical Research, 27(7), 1325-1336. [More Information]
  • Valet, O., Lankers, M., Adi, H., Traini, D., Young, P. (2010). The Use of High Throughput Raman Microscopy for the Concurrent Size Determination and Chemical Characterization of Inhalation Particles. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Haghi, M., Young, P., Traini, D., Jaiswal, R., Gong, J., Bebawy, M. (2010). Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model. Drug Development and Industrial Pharmacy, 36(10), 1207-1214. [More Information]
  • Wong, W., Adi, H., Traini, D., Chan, H., Fletcher, D., Crapper, J., Young, P. (2010). Use of Rapid Prototyping and Computational Fluid Dynamics in the Design of DPI Devices. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.

2009

  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Application of the Electrical Next Generation Impactor (eNGI) for the Electrostatic Characterization of Commercial Dry Powder Inhaler Formulations. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Traini, D., Young, P. (2009). Delivery of antibiotics to the respiratory tract: an update. Expert Opinion on Drug Delivery, 6(9), 897-905. [More Information]
  • Salama, R., Ladd, L., Chan, H., Traini, D., Young, P. (2009). Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. The AAPS Journal, 11(3), 465-468. [More Information]
  • Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
  • Wong, W., Traini, D., Chan, H., Crapper, J., Young, P. (2009). High Dose Respiratory Medicines: Pharmacopeia Methodologies for Determining Aerodynamic Mass Distributions. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Introduction of the Electrical Next Generation Impactor (eNGI) and Investigation of its Capabilities for the Study of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 26(2), 431-437. [More Information]
  • Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences, 38, 88-94. [More Information]
  • Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
  • Parlati, C., Colombo, P., Buttini, F., Young, P., Adi, H., Ammit, A., Traini, D. (2009). Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency. Pharmaceutical Research, 26(5), 1084-1092. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2009). Recent Advances in Controlled Release Pulmonary Therapy. Current Drug Delivery, 6(4), 404-414. [More Information]
  • Mezzena, M., Scalia, S., Young, P., Traini, D. (2009). Solid Lipid Budesonide Microparticles for Controlled Release Inhalation Therapy. The AAPS Journal, 11(4), 771-778. [More Information]
  • Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers. Pharmaceutical Research, 26(12), 2639-2646. [More Information]
  • Young, P., Adi, H., Patel, T., Law, K., Rogueda, P., Traini, D. (2009). The influence of micronised particulates on the aerosolisation properties of pressurised metered dose inhalers. Journal of Aerosol Science, 40, 324-337. [More Information]

2008

  • Young, P., Traini, D., Edge, S. (2008). Advances in Pulmonary Therapy. In Williams, Taft and McConville (Eds.), Advanced Drug Formulation Design to Optimize Therapeutic Outcome, (pp. 1-51). USA: Informa Healthcare.
  • Young, P., Roberts, D., Chiou, H., Rae, W., Chan, H., Traini, D. (2008). Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science, 39, 82-93. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2008). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, 97(8), 3356-3366. [More Information]
  • Hoe, S., Young, P., Rogueda, P., Traini, D. (2008). Determination of reference ultrasound parameters for model and hydrofluoroalkane propellants using high-resolution ultrasonic spectroscopy. AAPS PharmSciTech, 9(2), 605-611. [More Information]
  • Hoe, S., Young, P., Chan, H., Traini, D. (2008). Electrical Next Generation Impactor (eNGI): A New Method for Aerosol Electrostatics. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Salama, R., Ladd, L., Traini, D., Chan, H., Young, P. (2008). Formulation, Characterization and In Vitro - In Vivo Evaluation of Spray Dried Pulmonary Microparticles in an Ovine Animal Model. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Parlati, C., Adi, H., Buttini, F., Colombo, P., Young, P., Traini, D. (2008). In Vitro Evaluation of Co-Processed Antibiotic for Inhalation. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information]
  • Young, P., Nguyen, K., Jones, A., Traini, D. (2008). Microstructural Analysis of Porous Composite Materials: Dynamic Imaging of Drug Dissolution and Diffusion Through Porous Matrices. The AAPS Journal, DOI: 10.1208/s12248-008-9063-2(Print version 2008 Vol. 10 pp. 560-564), 1-5. [More Information]
  • Traini, D. (2008). Predicting Adhesion and Cohesion in Non-Aqueous Propellant Systems - Theory Versus Practice. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Salama, R., Hoe, S., Chan, H., Traini, D., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 486-495. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 145-152. [More Information]
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2008). Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences, 97(8), 3140-3152.
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D., Yang, R., Yu, A. (2008). Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir, 24(19), 11307-11312. [More Information]
  • Traini, D., Young, P., Thielmann, F., Acharya, M. (2008). The influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulations. Drug Development and Industrial Pharmacy, 34(9), 992-1001. [More Information]
  • Jones, M., Young, P., Traini, D., Shur, J., Edge, S., Price, R. (2008). The use of atomic force microscopy to study the conditioning of micronised budesonide. International Journal of Pharmaceutics, 357(1-2), 314-317. [More Information]
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D. (2008). Use of Scanning White Light Interferometry to Evaluate the Surface Roughness and Aerosol Performance of Spherical Micron-Sized Drug Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Traini, D., Loreti, G., Jones, A., Young, P. (2008). X-Ray Computed Microtomography for the Study of Modified Release Systems. Microscopy and Analysis, 22(1), 13-15.

2007

  • Adi, H., Young, P., Chan, H., Traini, D., Stewart, P. (2007). Cospray dried antibiotics for dry powder inhalation delivery. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2007). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, online(DOI 10.1002/jps.21239), 1-11. [More Information]
  • Chan, H., Young, P., Traini, D., Coates, M. (2007). Dry powder inhalers: challenges and goals for next generation therapies. Pharmaceutical Technology Europe, 19(4), 19-24.
  • Young, P., Edge, S., Staniforth, J., Steele, D., Traini, D., Price, R. (2007). Effect of Moisture on the Compressibility and Compactibility of Sodium Starch Glycolate. Pharmaceutical Development and Technology, 12(2), 217-222.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2007). In Vitro Investigation of Drug Particulates Interactions and Aerosol Performance of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 24(1), 125-135. [More Information]
  • Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
  • Young, P., Traini, D., Coates, M., Chan, H. (2007). Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, 394(2), 315-319.
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2007). Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences, 97(8), 3140-3152. [More Information]
  • Adi, H., Traini, D., Chan, H., Young, P. (2007). The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Sciences, Published online DOI 10.1002/jps.21195(Print version 2008 VOL. 97, NO. 7), 2780-2788. [More Information]
  • Young, P., Chan, H., Chiou, H., Edge, S., Tee, H., Traini, D. (2007). The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of Pharmaceutical Sciences, 96(5), 1331-1341. [More Information]
  • Rogueda, P., Traini, D. (2007). The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects. Expert Opinion on Drug Delivery, 4(6), 595-606. [More Information]
  • Rogueda, P., Traini, D. (2007). The nanoscale in pulmonary delivery. Part 2: formulation platforms. Expert Opinion on Drug Delivery, 4(6), 607-620. [More Information]
  • Young, P., Chiou, H., Tee, H., Traini, D., Chan, H., Thielmann, F., Burnett, D. (2007). The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, 33(1), 91-97. [More Information]

2006

  • Traini, D., Young, P., Price, R., Rogueda, P. (2006). A novel apparatus for the determination of solubility in pressurized metered dose inhalers. Drug Development and Industrial Pharmacy, 32(10), 1159-1163. [More Information]
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2006). Agglomerate Strength and Dispersion of Salmeterol Xinafoate from Powder Mixtures for Inhalation. Pharmaceutical Research, 23(11), 2556-2565. [More Information]
  • Traini, D., Young, P., Jones, M., Edge, S., Price, R. (2006). Comparative study of erythritol and lactose monohydrate as carriers for inhalation: atomic force microscopy and in vitro correlation. European Journal of Pharmaceutical Sciences, 27(2-3), 243-251. [More Information]
  • Young, P., Adi, H., Stewart, P., Traini, D. (2006). Effect of modification of lactose on its surface energy characteristics. Australasian Pharmaceutical Science Association (APSA).
  • Young, P., Naderi, M., Traini, D., Thielmann, F. (2006). Impact of Lactose Polymorphism on Salbutamol Sulphate Lactose Interactions in DPI Formulations. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2006). Investigation into the influence of polymeric stabilizing excipients on inter-particulate forces in pressurised metered dose inhalers. International Journal of Pharmaceutics, 320(1-2), 58-63. [More Information]
  • Young, P., Salama, R., Chan, H., Traini, D. (2006). Preparation and characterisation of controlled release microparticles for inhalation. Australasian Pharmaceutical Science Association (APSA).
  • Traini, D., Tee, H., Chiou, H., Chan, H., Young, P. (2006). The Effect of Mechanically Processed Pharmaceutical Carries for Dry Powder Inhalation on Drug Aerosolisation Performance. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2006). The use of AFM and surface energy measurements to investigate drug-canister material interactions in a model pressurized metered dose inhaler formulation. Aerosol Science and Technology, 40(4), 227-236.
  • Young, P., Chiou, H., Tee, E., Traini, D., Theilmann, F., Chan, H. (2006). The uses of a novel dynamic vapour sorption method to calculate low levels of amorphous content in lactose samples for dry powder inhaler formulations. Australasian Pharmaceutical Science Association (APSA).

2005

  • Young, P., Price, A., Traini, D. (2005). Coarse carriers, active sites and sticky drugs. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2005). Investigating particle interactions in non-aqueous model suspensions by surface energy and AFM measurements. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Traini, D., Rogueda, P., Young, P., Price, R. (2005). Surface Energy and Interparticle Force Correlation in Model pMDI Formulations. Pharmaceutical Research, 22(5), 816-825. [More Information]
  • Traini, D., Rogueda, P., Young, P., Price, R. (2005). Surface energy and interparticle forces correlations in model pMDI formulations. Pharmaceutical Research, 22(5), 816-25. [More Information]
  • Young, P., Edge, S., Traini, D., Jones, M., Price, R., El-Sabawi, D., Urry, C., Smith, C. (2005). The influence of dose on the performance of dry powder inhalation systems. International Journal of Pharmaceutics, 296(1-2), 26-33. [More Information]
  • Young, P., Traini, D., Rogueda, P., Price, A. (2005). The use of in vitro, AFM and surface energy measurements to predict pMDI aerosolisation performance. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.

2004

  • Young, P., Traini, D., Rogueda, P., Price, A. (2004). Study of particle adhesion to polymer coated pMDI canister walls: surface energy and AFM measurements. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.

2003

  • Young, P., Price, R., Lewis, D., Edge, S., Traini, D. (2003). Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope. Journal of Colloid and Interface Science, 262(1), 298-302.

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