Dr Darius Lane

BA, BSc (Hons), PhD
Postdoctoral Research Associate
Pathology, School of Medical Sciences

Telephone +61 2 9351-6144
Fax +61 2 9036 6549

Map

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Identifying the mechanisms by which ascorbate stimulates cellular iron uptake from transferrin.; Lane D, Richardson D; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).
  • Novel chemotherapeutic approaches for leukaemia: investigating the anti-cancer activity of ascorbate in relation to leukaemic iron metabolism; Lane D; Cancer Institute New South Wales/Early Career Development Fellowship.

Selected publications

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Journals

  • Lane, D., Lawen, A. (2014). A rapid and specific microplate assay for the determination of intra- and extracellular ascorbate in cultured cells. Journal of Visualized Experiments, 86(86), 1-10. [More Information]
  • Lane, D., Richardson, D. (2014). Can we target the alpha2-macroglobulin-hepcidin interaction to treat pathologic hypoferremia? Future Medicinal Chemistry, 6(1), 13-16. [More Information]
  • Lane, D., Mills, T., Shafie, N., Merlot, A., Saleh Moussa, R., Kalinowski, D., Kovacevic, Z., Richardson, D. (2014). Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial-mesenchymal transition. Biochimica et Biophysica Acta-Reviews on Cancer, 1845 (2), 166-181. [More Information]
  • Anzovino, A., Lane, D., Huang, M., Richardson, D. (2014). Fixing frataxin: "ironing out" the metabolic defect in friedreich's ataxia. British Journal of Pharmacology, 171(8), 2174-2190. [More Information]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1845 (1), 1-19. [More Information]
  • Lane, D., Merlot, A., Richardson, D. (2014). The lure of a LYR: The logistics of iron sulfur cluster delivery. Cell Metabolism, 19(3), 348-350. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. The Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]
  • Walcourt, A., Kurantsin-Mills, J., Kwagyan, J., Adenuga, B., Kalinowski, D., Lovejoy, D., Lane, D., Richardson, D. (2013). Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: Effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool. Journal of Inorganic Biochemistry, 129, 43-51. [More Information]
  • Lane, D., Huang, M., Ting, S., Sivagurunathan, S., Richardson, D. (2013). Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia. The Biochemical Journal, 453(3), 321-336. [More Information]
  • Lane, D., Huang, M., Richardson, D. (2013). Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression. The Biochemical Journal, 452(2), e3-e5. [More Information]
  • Lawen, A., Lane, D. (2013). Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action. Antioxidants & Redox Signaling, 18(18), 2473-2507. [More Information]
  • Lane, D., Saletta, F., Suryo Rahmanto, Y., Kovacevic, Z., Richardson, D. (2013). N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion. PLoS One, 8(2), 1-15. [More Information]
  • Lane, D., Lawen, A. (2013). The Glutamate Aspartate Transporter (GLAST) Mediates L: -Glutamate-Stimulated Ascorbate-Release Via Swelling-Activated Anion Channels in Cultured Neonatal Rodent Astrocytes. Cell Biochemistry and Biophysics, 65(2), 107-119. [More Information]
  • Lane, D., Chikhani, S., Richardson, V., Richardson, D. (2013). Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1833 (6), 1527-1541. [More Information]
  • Suryo Rahmanto, Y., Kalinowski, D., Lane, D., Lok, H., Richardson, V., Richardson, D. (2012). Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-Lived NO that is Trafficked by Interacting Proteins. Journal of Biological Chemistry, 287(10), 6960-6968. [More Information]
  • Huang, M., Lane, D., Richardson, D. (2011). Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease. Antioxidants & Redox Signaling, 15(12), 3003-3019. [More Information]
  • Lane, D., Robinson, S., Czerwinska, H., Lawen, A. (2010). A role for Na+/H+ exchangers and intracellular pH in regulating vitamin C-driven electron transport across the plasma membrane. Biochemical Journal, 428(2), 191-200. [More Information]
  • Lane, D., Richardson, D. (2010). Frataxin, a molecule of mystery: trading stability for function in its iron-binding site. Biochemical Journal, 426(2), e1-e3. [More Information]
  • Richardson, D., Lane, D., Becker, E., Huang, M., Suryo Rahmanto, Y., Sheftel, A., Ponka, P. (2010). Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 107(24), 10775-10782. [More Information]
  • Lane, D., Robinson, S., Czerwinska, H., Bishop, G., Lawen, A. (2010). Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron. Biochemical Journal, 432(1), 123-132. [More Information]

2014

  • Lane, D., Lawen, A. (2014). A rapid and specific microplate assay for the determination of intra- and extracellular ascorbate in cultured cells. Journal of Visualized Experiments, 86(86), 1-10. [More Information]
  • Lane, D., Richardson, D. (2014). Can we target the alpha2-macroglobulin-hepcidin interaction to treat pathologic hypoferremia? Future Medicinal Chemistry, 6(1), 13-16. [More Information]
  • Lane, D., Mills, T., Shafie, N., Merlot, A., Saleh Moussa, R., Kalinowski, D., Kovacevic, Z., Richardson, D. (2014). Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial-mesenchymal transition. Biochimica et Biophysica Acta-Reviews on Cancer, 1845 (2), 166-181. [More Information]
  • Anzovino, A., Lane, D., Huang, M., Richardson, D. (2014). Fixing frataxin: "ironing out" the metabolic defect in friedreich's ataxia. British Journal of Pharmacology, 171(8), 2174-2190. [More Information]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1845 (1), 1-19. [More Information]
  • Lane, D., Merlot, A., Richardson, D. (2014). The lure of a LYR: The logistics of iron sulfur cluster delivery. Cell Metabolism, 19(3), 348-350. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. The Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]

2013

  • Walcourt, A., Kurantsin-Mills, J., Kwagyan, J., Adenuga, B., Kalinowski, D., Lovejoy, D., Lane, D., Richardson, D. (2013). Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: Effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool. Journal of Inorganic Biochemistry, 129, 43-51. [More Information]
  • Lane, D., Huang, M., Ting, S., Sivagurunathan, S., Richardson, D. (2013). Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia. The Biochemical Journal, 453(3), 321-336. [More Information]
  • Lane, D., Huang, M., Richardson, D. (2013). Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression. The Biochemical Journal, 452(2), e3-e5. [More Information]
  • Lawen, A., Lane, D. (2013). Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action. Antioxidants & Redox Signaling, 18(18), 2473-2507. [More Information]
  • Lane, D., Saletta, F., Suryo Rahmanto, Y., Kovacevic, Z., Richardson, D. (2013). N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion. PLoS One, 8(2), 1-15. [More Information]
  • Lane, D., Lawen, A. (2013). The Glutamate Aspartate Transporter (GLAST) Mediates L: -Glutamate-Stimulated Ascorbate-Release Via Swelling-Activated Anion Channels in Cultured Neonatal Rodent Astrocytes. Cell Biochemistry and Biophysics, 65(2), 107-119. [More Information]
  • Lane, D., Chikhani, S., Richardson, V., Richardson, D. (2013). Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1833 (6), 1527-1541. [More Information]

2012

  • Suryo Rahmanto, Y., Kalinowski, D., Lane, D., Lok, H., Richardson, V., Richardson, D. (2012). Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-Lived NO that is Trafficked by Interacting Proteins. Journal of Biological Chemistry, 287(10), 6960-6968. [More Information]

2011

  • Huang, M., Lane, D., Richardson, D. (2011). Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease. Antioxidants & Redox Signaling, 15(12), 3003-3019. [More Information]

2010

  • Lane, D., Robinson, S., Czerwinska, H., Lawen, A. (2010). A role for Na+/H+ exchangers and intracellular pH in regulating vitamin C-driven electron transport across the plasma membrane. Biochemical Journal, 428(2), 191-200. [More Information]
  • Lane, D., Richardson, D. (2010). Frataxin, a molecule of mystery: trading stability for function in its iron-binding site. Biochemical Journal, 426(2), e1-e3. [More Information]
  • Richardson, D., Lane, D., Becker, E., Huang, M., Suryo Rahmanto, Y., Sheftel, A., Ponka, P. (2010). Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 107(24), 10775-10782. [More Information]
  • Lane, D., Robinson, S., Czerwinska, H., Bishop, G., Lawen, A. (2010). Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron. Biochemical Journal, 432(1), 123-132. [More Information]

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