Professor David Allen

Professor
Physiology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 4602
Fax +61 2 9351 2058

Website Related website

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Research interests

The Laboratory of Muscle Cell Function analyses heart and skeletal muscle function both in health and disease. Our main approach has been to isolate single cells (ventricular muscle, skeletal muscle, pacemaker cells) and use fluorescent indicators to measure key intracellular ionic concentrations, for instance Ca2+, Na+ and pH together with indicators of function, such as force, shortening or electrical activity. Increasingly we use Western blotting, immunohistochemistry and expression systems to identify and localize proteins in the cells under study.

We also perform some whole animals studies, for instance running mice on treadmills and running wheels, to understand how exercise modifies muscle behaviour and how drugs modify disease processes.

International links

Germany

(Research Centre, Karlsruhe.) Dr Rudiger Rudolf and I have collaborated on a study of genetically-encoded calcium sensors in muscle.

Hong Kong S.A.R.

(Hong Kong Polytechnic University) Collaboration with Dr Ella Yeung on mechanisms of stretch-induced damage in muscle.

New Zealand

(University of Auckland) Collaboration with Dr Marie Ward on the stretch-dependence of cardiac muscle.

Sweden

(Karolinska Institute, Stockholm) Long running collaboration (since 1989) with Dr Hakan Westerblad on mechanisms of fatigue in skeletal muscle.

United States

(University of New York at Buffalo) Professor Fred Sachs and I have a shared interest in stretch-activated channels and their role in disease.

Selected grants

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Intracellular calcium in intact muscle during fatigue and stretch-induced damage; Allen D; Australian Research Council (ARC)/Discovery Projects (DP).
  • Super-resolution fluorescence microscopy; Gaus K, Gandevia S, King N, Allen D, Vadas M, Ammit A, Grewal T, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Molecular mechanisms of cardiac function and disease; Graham R, Allen D, Fatkin D, Feneley M, Harvey R, MacDonald P; National Health and Medical Research Council (NHMRC)/Program Grants.

2009

  • Multiphoton microscope for Cellular Imaging in Live Animals; Leamey C, Phillips W, Dampney R, Westbrook R, Morley J, Arabzadeh E, Dreher B, Solomon S, Protti D, McGregor I, King N, Hunt N, Keay K, Allen D, Koeppl C, Cullen K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The role of calcium and TRPC channels in sinoatrial node ageing; Ju Y, Allen D, Cannell M; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Mechanisms of muscle damage in the mdx mouse; Allen D; University of Sydney/Bridging Support.

2005

  • Molecular Mechanisms Of Cardiac Function And Disease; Harvey M, Graham R, Feneley M, Allen D, Fatkin D, Feneley M, Harvey R; National Health and Medical Research Council (NHMRC)/Program Grants.
  • The role of intracellular calcium stores in cardiac pacemaking; Allen D; Australian Research Council (ARC)/Discovery Projects (DP).

2004

  • Regulation of the cardiac sodium/proton exchanger during ischaemia, reperfusion and preconditioning; Allen D, Jiang L; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Leica confocal trigger; Leica dissecting microsope; Allen D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • The role of intracellular calcium in fibre-type specific gene expression in skeletal muscle; Allen D; Australian Research Council (ARC)/Discovery Projects (DP).
  • Role of calcium stores and phosphate channels in muscle fatigue; Allen D, Laver D; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • The effect of ischaemia and reperfusion on sarcoplasmic reticulum calcium handling in the heart; Allen D, Ju Y; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Protection of the heart from ischaemic damage: role of calcium overload; Allen D; National Heart Foundation/Research Grant.

2000

  • Intracellular calcium in cardiac pacemaker cells and its relation to pacemaker currents; Allen D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Intracellular calcium in skeletal muscle during length changes; Allen D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Equipment to allow simultaneous voltage clamp and confocal microscopy on a single cell; Allen D, Cook D, Bennett M; Clive & Vera Ramaciotti Foundation/Research Grant.
  • Equipment for simultaneous confocal microscopy and patch clamping; Allen D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Role of intracellular ions in cardiac ischaemia and preconditioning; Allen D, Xiao X; Heart Foundation of Australia/Grants-in-Aid.
  • Calcium release in skeletal muscle studied by confocal microscopy; Allen D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Therapeutic targets for ischemic heart disease: agreement between Pfizer Pty Ltd and The University of Sydney; O'Connor S, Allen D; Pfizer Pty Ltd/Research Grants.
  • The role of Na-Ca exchange current in cardiac pacemaker cells; Allen D, Ju Y; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Allen, D., Ju, Y., Liu, J., Imtiaz, M. (2012). SOCE as a Determinant of Cardiac Pacemaker Activity. In Klaus Groschner, Wolfgang Graier and Christoph Romanin (Eds.), Store-operated Ca2+ Entry (SOCE) Pathways: Emerging Signaling Concepts in Human (PATHO)Physiology, (pp. 363-376). Vienna: Springer.
  • Allen, D., Ward, M. (2011). Roles of cardiac SAC beyond mechano-electric coupling: stretch-enhanced force generation and muscular dystrophy. In Peter Kohl; Frederick Sachs; M R Franz (Eds.), Cardiac Mechano-Electric Coupling and Arrhythmias, (pp. 435-441). Oxford: Oxford University Press.
  • Allen, D., Zhang, B., Whitehead, N. (2010). Stretch-Induced Membrane Damage in Muscle: Comparison of Wild-Type and mdx Mice. In D E Rassier (Eds.), Muscle Biophysics: From Molecules to Cells, (pp. 297-313). New York: Springer.
  • Westerblad, H., Allen, D. (2009). Cellular mechanisms of skeletal muscle fatigue. In Williams, Craig A~Ratel, Sebastien~ (Eds.), Human Muscle Fatigue, (pp. 48-75). United Kingdom: Routledge imprint of Taylor & Francis.
  • Allen, D., Lamb, G., Westerblad, H. (2008). Cellular mechanisms of skeletal muscle fatigue. In Taylor N.A.S., Groeller H. (Eds.), Physiological Bases of Human Performance During Work and Exercise, (pp. 115-125). Edinburgh: Churchill Livingstone.

Journals

  • Allen, D. (2013). Dynamic changes in the contractile apparatus during exercise. Acta Physiologica, 208(3), 220-221. [More Information]
  • Allen, D., Halligan, R. (2013). The function of animal ethics committees. Between the Species, 16(1), 1-5.
  • Ju, Y., Woodcock, E., Allen, D., Cannell, M. (2012). Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms. Journal of Molecular and Cellular Cardiology, 53(3), 375-381. [More Information]
  • Zhang, B., Whitehead, N., Gervasio, O., Reardon, T., Vale, M., Fatkin, D., Dietrich, A., Yeung, E., Allen, D. (2012). Pathways of Ca2+ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle. Journal of Applied Physiology, 112(12), 2077-2086. [More Information]
  • Allen, D., Trajanovska, S. (2012). The multiple roles of phosphate in muscle fatigue. Frontiers in Physiology, 3, 1-8. [More Information]
  • Gervasio, O., Phillips, W., Cole, L., Allen, D. (2011). Caveolae respond to cell stretch and contribute to stretch-induced signaling. Journal of Cell Science, 124(21), 3581-3590. [More Information]
  • Ju, Y., Liu, J., Lee, B., Lai, D., Woodcock, E., Lei, M., Cannell, M., Allen, D. (2011). Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node. Circulation Research, 109(8), 848-857. [More Information]
  • Allen, D., Whitehead, N. (2011). Duchenne muscular dystrophy – What causes the increased membrane permeability in skeletal muscle? The International Journal of Biochemistry and Cell Biology, 43(3), 290-294. [More Information]
  • Westerblad, H., Allen, D. (2011). Emerging Roles of ROS/RNS in Muscle Function and Fatigue. Antioxidants & Redox Signaling, 15(9), 2487-2499. [More Information]
  • Allen, D., Clugston, E., Petersen, Y., Röder, I., Chapman, B., Rudolf, R. (2011). Interactions between intracellular calcium and phosphate in intact mouse muscle during fatigue. Journal of Applied Physiology, 111(2), 358-366. [More Information]
  • Mohl, M., lismaa, S., Xiao, X., Friedrich, O., Wagner, S., Nikolova-Krstevski, V., Wu, J., Yu, Z., Feneley, M., Fatkin, D., Allen, D., et al (2011). Regulation of murine cardiac contractility by activation of a1A-adrenergic receptor-operated Ca 2+ entry. Cardiovascular Research, 91, 310-319. [More Information]
  • Guo, W., Shi, X., Liu, A., Yang, G., Yu, F., Zheng, Q., Wang, Z., Allen, D., Lu, Z. (2011). RNA binding protein QKI inhibits the ischemia/reperfusion-induced apoptosis in neonatal cardiomyocytes. Cellular Physiology and Biochemistry, 28(4), 593-602. [More Information]
  • Allen, D., Gervasio, O., Yeung, E., Whitehead, N. (2010). Calcium and the damage pathways in muscular dystrophy. Canadian Journal of Physiology and Pharmacology, 88(2), 83-91. [More Information]
  • Whitehead, N., Yeung, E., Froehner, S., Allen, D. (2010). Skeletal Muscle NADPH Oxidase Is Increased and Triggers Stretch-Induced Damage in the mdx Mouse. PLoS One, 5(12), e15354-1-e15354-10. [More Information]
  • Allen, D., Westerblad, H. (2010). What limits exercise during high-intensity aerobic exercise? European Journal of Applied Physiology, 110(3), 661-662. [More Information]
  • Reardon, T., Allen, D. (2009). Iron injections in mice increase skeletal muscle iron content, induce oxidative stress and reduce exercise performance. Experimental Physiology, 94(6), 720-730. [More Information]
  • Reardon, T., Allen, D. (2009). Time to fatigue is increased in mouse muscle at 37°C; the role of iron and reactive oxygen species. The Journal of Physiology, 587(19), 4705-4716. [More Information]
  • Murphy, E., Allen, D. (2009). Why did the NHE inhibitor clinical trials fail? Journal of Molecular and Cellular Cardiology, 46(2), 137-141. [More Information]
  • Allen, D. (2008). Fatigue in working muscles. Journal of Applied Physiology, 106, 358-9. [More Information]
  • Allen, D., Lamb, G., Westerblad, H. (2008). Impaired calcium release during fatigue. Journal of Applied Physiology, 104(1), 296-305. [More Information]
  • Whitehead, N., Pham, C., Gervasio, O., Allen, D. (2008). N-Acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice. The Journal of Physiology, 586(7), 2003-2014. [More Information]
  • Zhang, B., Yeung, S., Allen, D., Qin, L., Yeung, E. (2008). Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions. Journal of Applied Physiology, 105(1), 352-357. [More Information]
  • Allen, D., Lamb, G., Westerblad, H. (2008). Skeletal muscle fatigue: cellular mechanisms. Physiological Reviews, 88(1), 287-332. [More Information]
  • Ward, M., Williams, I., Chu, Y., Cooper, P., Ju, Y., Allen, D. (2008). Stretch-activated channels in the heart: contributions to length-dependence and to cardiomyopathy. Progress in Biophysics and Molecular Biology, 97(2-3), 232-249. [More Information]
  • Gervasio, O., Whitehead, N., Yeung, E., Phillips, W., Allen, D. (2008). TRPC1 binds to caveolin-3 and is regulated by Src kinase – role in Duchenne muscular dystrophy. Journal of Cell Science, 121(13), 2246-2255. [More Information]
  • Aydin, J., Korhonen, T., Tavi, P., Allen, D., Westerblad, H., Bruton, J. (2007). Activation of Ca2+-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca2+ release. Acta Physiologica, 191(2), 131-137.
  • Williams, I., Allen, D. (2007). Improved Ca2+ handling and reduced inflammation in mdx (dystrophic) mice hearts following in vivo antioxidant treatment. Journal of Molecular and Cellular Cardiology, 42(6 Suppl 1), S165.
  • Ju, Y., Allen, D. (2007). Store-Operated Ca(2+) Entry and TRPC Expression; Possible Roles in Cardiac Pacemaker Tissue. Heart, Lung and Circulation, 16(5), 349-355. [More Information]
  • Ju, Y., Chu, Y., Chaulet, H., Lai, D., Gervasio, O., Graham, R., Cannell, M., Allen, D. (2007). Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node. Circulation Research, 100(11), 1605-1614. [More Information]
  • Ward, M., Allen, D. (2007). Stretch-mediated changes in intracellular Ca2+ in isolated mouse myocardium. Journal of Molecular and Cellular Cardiology, 42(6 Suppl 1), S107.
  • Williams, I., Xiao, X., Ju, Y., Allen, D. (2007). The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms. Pfluegers Archiv: European journal of physiology, 454(6), 903-912. [More Information]
  • Williams, I., Allen, D. (2007). The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice. American Journal of Physiology: Heart and Circulatory Physiology, 293(3), H1969-H1977. [More Information]
  • Allen, D., Westerblad, H. (2007). Understanding muscle from its length. The Journal of Physiology, 583(1), 3-4. [More Information]
  • Moopanar, T., Xiao, X., Jiang, L., Chen, Z., Kemp, B., Allen, D. (2006). AICAR inhibits the Na+/H+ exchanger in rat hearts-possible contribution to cardioprotection. Pfluegers Archiv: European journal of physiology, 453(2), 147-156. [More Information]
  • Williams, I., Allen, D. (2006). Altered calcium handling in young and old mdx mice: The role of the stretch-activated channel. Journal of Molecular and Cellular Cardiology, 41(4), 751.
  • Ju, Y., Allen, D., Cannell, M. (2006). Confocal images of the spontaneous Ca2+ activity in the mouse sino-atrial node. Journal of Molecular and Cellular Cardiology, 41(4), 738-738.
  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006). Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene Therapy (Basingstoke), 13(22), 1611-1615. [More Information]
  • Williams, I., Allen, D. (2006). Intracellular calcium handling in ventricular myocytes from mdx mice. American Journal of Physiology: Heart and Circulatory Physiology, 292(2), H846-H855. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Bailey, C., Rasko, J., Allen, D., Semsarian, C. (2006). Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 41(4), 623-632. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Rasko, J., Bailey, C., Allen, D., Semsarian, C. (2006). Mouse cardiac troponin I model of hypertrophic cardiomyopathy: Phenotype associated with abnormal calcium handling. Journal of Molecular and Cellular Cardiology, 41(4), 747 (abstract 41)-747.
  • Whitehead, N., Yeung, E., Allen, D. (2006). Muscle damage in mdx (dystrophic) mice: role of calcium and reactive oxygen species. Clinical and Experimental Pharmacology and Physiology, 33(7), 657-662. [More Information]
  • Whitehead, N., Streamer, M., Lusambili, L., Sachs, F., Allen, D. (2006). Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice. Neuromuscular Disorders, 16(12), 845-854. [More Information]
  • Moopanar, T., Allen, D. (2006). The activity-induced reduction of myofibrillar Ca2+ sensitivity in mouse skeletal muscle is reversed by dithiothreitol. The Journal of Physiology, 571(1), 191-200. [More Information]
  • Chu, Y., Allen, D., Ju, Y. (2006). The immunolocalization of TRPC1 in mouse sino-atrial node. Journal of Molecular and Cellular Cardiology, 41(4), 735-735.
  • Allen, D. (2006). Why stretched muscles hurt - Is there a role for half-sarcomere dynamics? The Journal of Physiology, 573(1), 4. [More Information]
  • Williams, I., Allen, D. (2005). Abnormal calcium transients in cardiomyocytes from mdx (dystrophic) mice. Journal of Molecular and Cellular Cardiology, 39(3), 565.
  • Ju, Y., Allen, D. (2005). Cyanide inhibits the Na+/Ca2+ exchanger in isolated cardiac pacemaker cells of the cane toad. Pfluegers Archiv: European journal of physiology, 449(5), 442-448. [More Information]
  • Yeung, E., Whitehead, N., Suchyna, T., Gottlieb, P., Sachs, F., Allen, D. (2005). Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse. The Journal of Physiology, 562(2), 367-380.
  • Kizana, E., Ginn, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation, 111(4), 394-398. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Thomas, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts Modulate Cardiomyocyte Excitability: Insights from Fibroblasts with Genetically Altered Connexin43 Expression. Journal of Gene Medicine, 7(point P8 on page 1127), 1127-1127.
  • Allen, D., Whitehead, N., Yeung, E. (2005). Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: role of ionic changes. The Journal of Physiology, 567(3), 723-735. [More Information]
  • Moopanar, T., Allen, D. (2005). Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 degrees C. The Journal of Physiology, 564(Part 1), 189-199. [More Information]
  • Ju, Y., Allen, D. (2005). Store-operated CA(2+) entry in mouse sinoatrial node. Journal of Molecular and Cellular Cardiology, 38(6), 1032-1032.
  • Ju, Y., Chaulet, H., Graham, R., Allen, D. (2005). Store-operated Ca2+ channel activity and expression of TRPCs genes in mouse sinoatrial node. Journal of Molecular and Cellular Cardiology, 39(1), 170-170.
  • Allen, D., Hardeman, E., North, K., Alexander, I., Cooper, S., Maxwell, A., Kizana, E., Ghoddusi, M. (2004). C2C12 Co-Culture On A Fibroblast Substratum Enables Sustained Survival Of Contractile, Highly Differentiated Myotubes With Peripheral Nuclei And Adult Fast Myosin Expression. Cell Motility and the Cytoskeleton, 58(3), 200-211. [More Information]
  • Ju, Y., Allen, D. (2004). Cyanide inhibits Na+-Ca2+ exchanger in single pacemaker cells isolated from sinus venosus of cane toad. Journal of Molecular and Cellular Cardiology, 37(1), 231-231.
  • Allen, D., Ju, Y. (2004). Lessons from the toad pacemaker cells; role of intracellular calcium. Journal of Molecular and Cellular Cardiology, 37(1), 339-340.
  • Williams, I., Xiao, X., Ju, Y., Allen, D. (2004). Rise of intracellular Na2+during cardiac ischaemia: the underlying mechanisms. Journal of Molecular and Cellular Cardiology, 37(1), 232-232.
  • Allen, D. (2004). Skeletal Muscle Function: Role Of Ionic Changes In Fatigue, Damage And Disease. Clinical and Experimental Pharmacology and Physiology, 31(8), 485-493.
  • Yeung, E., Allen, D. (2004). Stretch-Activated Channels In Stretch-Induced Muscle Damage: Role In Muscular Dystrophy. Clinical and Experimental Pharmacology and Physiology, 31(8), 551-556.
  • Ju, Y., Huang, W., Jiang, L., Barden, J., Allen, D. (2003). ATP modulates intracellular Ca2+ and firing rate through a P2Y 1 purinoceptor in cane toad pacemaker cells. The Journal of Physiology, 552(3), 777-787.
  • Tavi, P., Allen, D., Niemela, P., Vuolteenaho, O., Weckström, M., Westerblad, H. (2003). Calmodulin kinase modulates Ca2+ release in mouse skeletal muscle. The Journal of Physiology, 551, 5-12.
  • Ju, Y., Allen, D. (2003). Early effects of metabolic inhibition on intracellular Ca2+ in toad pacemaker cells: involvement of Ca2+ stores. American Journal of Physiology: Heart and Circulatory Physiology, 284(4), H1087-H1094.
  • Yeung, E., Head, S., Allen, D. (2003). Gadolinium reduces short-term stretch-induced muscle damage in isolated mdx mouse muscle fibres. The Journal of Physiology, 552(2), 449-458.
  • Ju, Y., Wu, M., Chaulet, H., Marciniec, T., Graham, R., Allen, D. (2003). IGF-1 enhances a store-operated Ca2+ channel in skeletal muscle myoblasts: involvement of a CD20-like protein. Journal of Cellular Physiology, 197(1), 53-60. [More Information]
  • Yeung, E., Bourreau, J., Allen, D., Ballard, H. (2003). Intracellular sodium in mammalian muscle fibers after eccentric contractions. Journal of Applied Physiology, 94(6), 2475-2482.
  • Allen, D., Xiao, X. (2003). Role of the cardiac Na+ /H+ exchanger during ischemia and reperfusion. Cardiovascular Research, 57(4), 934-941.
  • Xiao, X., Allen, D. (2003). The cardioprotective effects of Na+/H+ exchange inhibition and mitochondrial K ATP channel activation are additive in the isolated rat heart. Pfluegers Archiv: European journal of physiology, 447(3), 272-279. [More Information]
  • Xiao, X., Allen, D. (2003). The role of endogenous angiotensin II in ischaemia, reperfusion and preconditioning of the isolated rat heart. Pfluegers Archiv: European journal of physiology, 445(6), 643-650.
  • Yeung, E., Balnave, C., Ballard, H., Bourreau, J., Allen, D. (2002). Development of T-tubular vacuoles in eccentrically damaged mouse muscle fibres. The Journal of Physiology, 540(2), 581-592.
  • Allen, D., Lannergren, J., Westerblad, H. (2002). Intracellular ATP measured with lucferin/luciferase in isolated single skeletal muscle fibres. Pfluegers Archiv: European journal of physiology, 443(5-6), 836-842. [More Information]
  • Westerblad, H., Allen, D., Lännergren, J. (2002). Muscle fatigue: Lactic acid or inorganic phosphate the Major cause? Physiology, 17(1), 17-21.
  • Allen, D., Westerblad, H., Kabbarra, A. (2002). Muscle Fatigue: The role of intracellular calcium stores. Journal of Applied Physiology, 27(1), 83-96.
  • Allen, D., Westerblad, H. (2002). Recent advances in the understanding of skeletal muscle fatigue. Current Opinion In Rheumatology, 14(6), 648-652.
  • Ju, Y., Allen, D. (2001). Does Ca2+ release from the sarcoplasmic reticulum influence heart rate? Clinical and Experimental Pharmacology and Physiology, 28, 703-708.
  • Allen, D. (2001). Eccentric Muscle damage: mechanisms of early reduction of force. Acta Physiologica, 171, 311-319.
  • Allen, D., Xiao, X. (2001). Na+ entry during ischemia, reperfusion and preconditioning. Cardiovascular Research, 50, 164-166.
  • Allen, D., Westerblad, H. (2001). Role of Phosphate and calcium stores in muscle fatigue. The Journal of Physiology, 536.3, 657-665.
  • Kabbara, A., Allen, D. (2001). The use of the inidicator fluo-FN to measure sarcoplasmic reticulum calcium in single muslce fibres of the cane toad. The Journal of Physiology, 534.1, 87-97.

2013

  • Allen, D. (2013). Dynamic changes in the contractile apparatus during exercise. Acta Physiologica, 208(3), 220-221. [More Information]
  • Allen, D., Halligan, R. (2013). The function of animal ethics committees. Between the Species, 16(1), 1-5.

2012

  • Ju, Y., Woodcock, E., Allen, D., Cannell, M. (2012). Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms. Journal of Molecular and Cellular Cardiology, 53(3), 375-381. [More Information]
  • Zhang, B., Whitehead, N., Gervasio, O., Reardon, T., Vale, M., Fatkin, D., Dietrich, A., Yeung, E., Allen, D. (2012). Pathways of Ca2+ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle. Journal of Applied Physiology, 112(12), 2077-2086. [More Information]
  • Allen, D., Ju, Y., Liu, J., Imtiaz, M. (2012). SOCE as a Determinant of Cardiac Pacemaker Activity. In Klaus Groschner, Wolfgang Graier and Christoph Romanin (Eds.), Store-operated Ca2+ Entry (SOCE) Pathways: Emerging Signaling Concepts in Human (PATHO)Physiology, (pp. 363-376). Vienna: Springer.
  • Allen, D., Trajanovska, S. (2012). The multiple roles of phosphate in muscle fatigue. Frontiers in Physiology, 3, 1-8. [More Information]

2011

  • Gervasio, O., Phillips, W., Cole, L., Allen, D. (2011). Caveolae respond to cell stretch and contribute to stretch-induced signaling. Journal of Cell Science, 124(21), 3581-3590. [More Information]
  • Ju, Y., Liu, J., Lee, B., Lai, D., Woodcock, E., Lei, M., Cannell, M., Allen, D. (2011). Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node. Circulation Research, 109(8), 848-857. [More Information]
  • Allen, D., Whitehead, N. (2011). Duchenne muscular dystrophy – What causes the increased membrane permeability in skeletal muscle? The International Journal of Biochemistry and Cell Biology, 43(3), 290-294. [More Information]
  • Westerblad, H., Allen, D. (2011). Emerging Roles of ROS/RNS in Muscle Function and Fatigue. Antioxidants & Redox Signaling, 15(9), 2487-2499. [More Information]
  • Allen, D., Clugston, E., Petersen, Y., Röder, I., Chapman, B., Rudolf, R. (2011). Interactions between intracellular calcium and phosphate in intact mouse muscle during fatigue. Journal of Applied Physiology, 111(2), 358-366. [More Information]
  • Mohl, M., lismaa, S., Xiao, X., Friedrich, O., Wagner, S., Nikolova-Krstevski, V., Wu, J., Yu, Z., Feneley, M., Fatkin, D., Allen, D., et al (2011). Regulation of murine cardiac contractility by activation of a1A-adrenergic receptor-operated Ca 2+ entry. Cardiovascular Research, 91, 310-319. [More Information]
  • Guo, W., Shi, X., Liu, A., Yang, G., Yu, F., Zheng, Q., Wang, Z., Allen, D., Lu, Z. (2011). RNA binding protein QKI inhibits the ischemia/reperfusion-induced apoptosis in neonatal cardiomyocytes. Cellular Physiology and Biochemistry, 28(4), 593-602. [More Information]
  • Allen, D., Ward, M. (2011). Roles of cardiac SAC beyond mechano-electric coupling: stretch-enhanced force generation and muscular dystrophy. In Peter Kohl; Frederick Sachs; M R Franz (Eds.), Cardiac Mechano-Electric Coupling and Arrhythmias, (pp. 435-441). Oxford: Oxford University Press.

2010

  • Allen, D., Gervasio, O., Yeung, E., Whitehead, N. (2010). Calcium and the damage pathways in muscular dystrophy. Canadian Journal of Physiology and Pharmacology, 88(2), 83-91. [More Information]
  • Whitehead, N., Yeung, E., Froehner, S., Allen, D. (2010). Skeletal Muscle NADPH Oxidase Is Increased and Triggers Stretch-Induced Damage in the mdx Mouse. PLoS One, 5(12), e15354-1-e15354-10. [More Information]
  • Allen, D., Zhang, B., Whitehead, N. (2010). Stretch-Induced Membrane Damage in Muscle: Comparison of Wild-Type and mdx Mice. In D E Rassier (Eds.), Muscle Biophysics: From Molecules to Cells, (pp. 297-313). New York: Springer.
  • Allen, D., Westerblad, H. (2010). What limits exercise during high-intensity aerobic exercise? European Journal of Applied Physiology, 110(3), 661-662. [More Information]

2009

  • Westerblad, H., Allen, D. (2009). Cellular mechanisms of skeletal muscle fatigue. In Williams, Craig A~Ratel, Sebastien~ (Eds.), Human Muscle Fatigue, (pp. 48-75). United Kingdom: Routledge imprint of Taylor & Francis.
  • Reardon, T., Allen, D. (2009). Iron injections in mice increase skeletal muscle iron content, induce oxidative stress and reduce exercise performance. Experimental Physiology, 94(6), 720-730. [More Information]
  • Reardon, T., Allen, D. (2009). Time to fatigue is increased in mouse muscle at 37°C; the role of iron and reactive oxygen species. The Journal of Physiology, 587(19), 4705-4716. [More Information]
  • Murphy, E., Allen, D. (2009). Why did the NHE inhibitor clinical trials fail? Journal of Molecular and Cellular Cardiology, 46(2), 137-141. [More Information]

2008

  • Allen, D., Lamb, G., Westerblad, H. (2008). Cellular mechanisms of skeletal muscle fatigue. In Taylor N.A.S., Groeller H. (Eds.), Physiological Bases of Human Performance During Work and Exercise, (pp. 115-125). Edinburgh: Churchill Livingstone.
  • Allen, D. (2008). Fatigue in working muscles. Journal of Applied Physiology, 106, 358-9. [More Information]
  • Allen, D., Lamb, G., Westerblad, H. (2008). Impaired calcium release during fatigue. Journal of Applied Physiology, 104(1), 296-305. [More Information]
  • Whitehead, N., Pham, C., Gervasio, O., Allen, D. (2008). N-Acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice. The Journal of Physiology, 586(7), 2003-2014. [More Information]
  • Zhang, B., Yeung, S., Allen, D., Qin, L., Yeung, E. (2008). Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions. Journal of Applied Physiology, 105(1), 352-357. [More Information]
  • Allen, D., Lamb, G., Westerblad, H. (2008). Skeletal muscle fatigue: cellular mechanisms. Physiological Reviews, 88(1), 287-332. [More Information]
  • Ward, M., Williams, I., Chu, Y., Cooper, P., Ju, Y., Allen, D. (2008). Stretch-activated channels in the heart: contributions to length-dependence and to cardiomyopathy. Progress in Biophysics and Molecular Biology, 97(2-3), 232-249. [More Information]
  • Gervasio, O., Whitehead, N., Yeung, E., Phillips, W., Allen, D. (2008). TRPC1 binds to caveolin-3 and is regulated by Src kinase – role in Duchenne muscular dystrophy. Journal of Cell Science, 121(13), 2246-2255. [More Information]

2007

  • Aydin, J., Korhonen, T., Tavi, P., Allen, D., Westerblad, H., Bruton, J. (2007). Activation of Ca2+-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca2+ release. Acta Physiologica, 191(2), 131-137.
  • Williams, I., Allen, D. (2007). Improved Ca2+ handling and reduced inflammation in mdx (dystrophic) mice hearts following in vivo antioxidant treatment. Journal of Molecular and Cellular Cardiology, 42(6 Suppl 1), S165.
  • Ju, Y., Allen, D. (2007). Store-Operated Ca(2+) Entry and TRPC Expression; Possible Roles in Cardiac Pacemaker Tissue. Heart, Lung and Circulation, 16(5), 349-355. [More Information]
  • Ju, Y., Chu, Y., Chaulet, H., Lai, D., Gervasio, O., Graham, R., Cannell, M., Allen, D. (2007). Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node. Circulation Research, 100(11), 1605-1614. [More Information]
  • Ward, M., Allen, D. (2007). Stretch-mediated changes in intracellular Ca2+ in isolated mouse myocardium. Journal of Molecular and Cellular Cardiology, 42(6 Suppl 1), S107.
  • Williams, I., Xiao, X., Ju, Y., Allen, D. (2007). The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms. Pfluegers Archiv: European journal of physiology, 454(6), 903-912. [More Information]
  • Williams, I., Allen, D. (2007). The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice. American Journal of Physiology: Heart and Circulatory Physiology, 293(3), H1969-H1977. [More Information]
  • Allen, D., Westerblad, H. (2007). Understanding muscle from its length. The Journal of Physiology, 583(1), 3-4. [More Information]

2006

  • Moopanar, T., Xiao, X., Jiang, L., Chen, Z., Kemp, B., Allen, D. (2006). AICAR inhibits the Na+/H+ exchanger in rat hearts-possible contribution to cardioprotection. Pfluegers Archiv: European journal of physiology, 453(2), 147-156. [More Information]
  • Williams, I., Allen, D. (2006). Altered calcium handling in young and old mdx mice: The role of the stretch-activated channel. Journal of Molecular and Cellular Cardiology, 41(4), 751.
  • Ju, Y., Allen, D., Cannell, M. (2006). Confocal images of the spontaneous Ca2+ activity in the mouse sino-atrial node. Journal of Molecular and Cellular Cardiology, 41(4), 738-738.
  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006). Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene Therapy (Basingstoke), 13(22), 1611-1615. [More Information]
  • Williams, I., Allen, D. (2006). Intracellular calcium handling in ventricular myocytes from mdx mice. American Journal of Physiology: Heart and Circulatory Physiology, 292(2), H846-H855. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Bailey, C., Rasko, J., Allen, D., Semsarian, C. (2006). Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 41(4), 623-632. [More Information]
  • Tsoutsman, T., Chung, J., Doolan, A., Nguyen, L., Williams, I., Tu, E., Lam, L., Rasko, J., Bailey, C., Allen, D., Semsarian, C. (2006). Mouse cardiac troponin I model of hypertrophic cardiomyopathy: Phenotype associated with abnormal calcium handling. Journal of Molecular and Cellular Cardiology, 41(4), 747 (abstract 41)-747.
  • Whitehead, N., Yeung, E., Allen, D. (2006). Muscle damage in mdx (dystrophic) mice: role of calcium and reactive oxygen species. Clinical and Experimental Pharmacology and Physiology, 33(7), 657-662. [More Information]
  • Whitehead, N., Streamer, M., Lusambili, L., Sachs, F., Allen, D. (2006). Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice. Neuromuscular Disorders, 16(12), 845-854. [More Information]
  • Moopanar, T., Allen, D. (2006). The activity-induced reduction of myofibrillar Ca2+ sensitivity in mouse skeletal muscle is reversed by dithiothreitol. The Journal of Physiology, 571(1), 191-200. [More Information]
  • Chu, Y., Allen, D., Ju, Y. (2006). The immunolocalization of TRPC1 in mouse sino-atrial node. Journal of Molecular and Cellular Cardiology, 41(4), 735-735.
  • Allen, D. (2006). Why stretched muscles hurt - Is there a role for half-sarcomere dynamics? The Journal of Physiology, 573(1), 4. [More Information]

2005

  • Williams, I., Allen, D. (2005). Abnormal calcium transients in cardiomyocytes from mdx (dystrophic) mice. Journal of Molecular and Cellular Cardiology, 39(3), 565.
  • Ju, Y., Allen, D. (2005). Cyanide inhibits the Na+/Ca2+ exchanger in isolated cardiac pacemaker cells of the cane toad. Pfluegers Archiv: European journal of physiology, 449(5), 442-448. [More Information]
  • Yeung, E., Whitehead, N., Suchyna, T., Gottlieb, P., Sachs, F., Allen, D. (2005). Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse. The Journal of Physiology, 562(2), 367-380.
  • Kizana, E., Ginn, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation, 111(4), 394-398. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Thomas, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts Modulate Cardiomyocyte Excitability: Insights from Fibroblasts with Genetically Altered Connexin43 Expression. Journal of Gene Medicine, 7(point P8 on page 1127), 1127-1127.
  • Allen, D., Whitehead, N., Yeung, E. (2005). Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: role of ionic changes. The Journal of Physiology, 567(3), 723-735. [More Information]
  • Moopanar, T., Allen, D. (2005). Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 degrees C. The Journal of Physiology, 564(Part 1), 189-199. [More Information]
  • Ju, Y., Allen, D. (2005). Store-operated CA(2+) entry in mouse sinoatrial node. Journal of Molecular and Cellular Cardiology, 38(6), 1032-1032.
  • Ju, Y., Chaulet, H., Graham, R., Allen, D. (2005). Store-operated Ca2+ channel activity and expression of TRPCs genes in mouse sinoatrial node. Journal of Molecular and Cellular Cardiology, 39(1), 170-170.

2004

  • Allen, D., Hardeman, E., North, K., Alexander, I., Cooper, S., Maxwell, A., Kizana, E., Ghoddusi, M. (2004). C2C12 Co-Culture On A Fibroblast Substratum Enables Sustained Survival Of Contractile, Highly Differentiated Myotubes With Peripheral Nuclei And Adult Fast Myosin Expression. Cell Motility and the Cytoskeleton, 58(3), 200-211. [More Information]
  • Ju, Y., Allen, D. (2004). Cyanide inhibits Na+-Ca2+ exchanger in single pacemaker cells isolated from sinus venosus of cane toad. Journal of Molecular and Cellular Cardiology, 37(1), 231-231.
  • Allen, D., Ju, Y. (2004). Lessons from the toad pacemaker cells; role of intracellular calcium. Journal of Molecular and Cellular Cardiology, 37(1), 339-340.
  • Williams, I., Xiao, X., Ju, Y., Allen, D. (2004). Rise of intracellular Na2+during cardiac ischaemia: the underlying mechanisms. Journal of Molecular and Cellular Cardiology, 37(1), 232-232.
  • Allen, D. (2004). Skeletal Muscle Function: Role Of Ionic Changes In Fatigue, Damage And Disease. Clinical and Experimental Pharmacology and Physiology, 31(8), 485-493.
  • Yeung, E., Allen, D. (2004). Stretch-Activated Channels In Stretch-Induced Muscle Damage: Role In Muscular Dystrophy. Clinical and Experimental Pharmacology and Physiology, 31(8), 551-556.

2003

  • Ju, Y., Huang, W., Jiang, L., Barden, J., Allen, D. (2003). ATP modulates intracellular Ca2+ and firing rate through a P2Y 1 purinoceptor in cane toad pacemaker cells. The Journal of Physiology, 552(3), 777-787.
  • Tavi, P., Allen, D., Niemela, P., Vuolteenaho, O., Weckström, M., Westerblad, H. (2003). Calmodulin kinase modulates Ca2+ release in mouse skeletal muscle. The Journal of Physiology, 551, 5-12.
  • Ju, Y., Allen, D. (2003). Early effects of metabolic inhibition on intracellular Ca2+ in toad pacemaker cells: involvement of Ca2+ stores. American Journal of Physiology: Heart and Circulatory Physiology, 284(4), H1087-H1094.
  • Yeung, E., Head, S., Allen, D. (2003). Gadolinium reduces short-term stretch-induced muscle damage in isolated mdx mouse muscle fibres. The Journal of Physiology, 552(2), 449-458.
  • Ju, Y., Wu, M., Chaulet, H., Marciniec, T., Graham, R., Allen, D. (2003). IGF-1 enhances a store-operated Ca2+ channel in skeletal muscle myoblasts: involvement of a CD20-like protein. Journal of Cellular Physiology, 197(1), 53-60. [More Information]
  • Yeung, E., Bourreau, J., Allen, D., Ballard, H. (2003). Intracellular sodium in mammalian muscle fibers after eccentric contractions. Journal of Applied Physiology, 94(6), 2475-2482.
  • Allen, D., Xiao, X. (2003). Role of the cardiac Na+ /H+ exchanger during ischemia and reperfusion. Cardiovascular Research, 57(4), 934-941.
  • Xiao, X., Allen, D. (2003). The cardioprotective effects of Na+/H+ exchange inhibition and mitochondrial K ATP channel activation are additive in the isolated rat heart. Pfluegers Archiv: European journal of physiology, 447(3), 272-279. [More Information]
  • Xiao, X., Allen, D. (2003). The role of endogenous angiotensin II in ischaemia, reperfusion and preconditioning of the isolated rat heart. Pfluegers Archiv: European journal of physiology, 445(6), 643-650.

2002

  • Yeung, E., Balnave, C., Ballard, H., Bourreau, J., Allen, D. (2002). Development of T-tubular vacuoles in eccentrically damaged mouse muscle fibres. The Journal of Physiology, 540(2), 581-592.
  • Allen, D., Lannergren, J., Westerblad, H. (2002). Intracellular ATP measured with lucferin/luciferase in isolated single skeletal muscle fibres. Pfluegers Archiv: European journal of physiology, 443(5-6), 836-842. [More Information]
  • Westerblad, H., Allen, D., Lännergren, J. (2002). Muscle fatigue: Lactic acid or inorganic phosphate the Major cause? Physiology, 17(1), 17-21.
  • Allen, D., Westerblad, H., Kabbarra, A. (2002). Muscle Fatigue: The role of intracellular calcium stores. Journal of Applied Physiology, 27(1), 83-96.
  • Allen, D., Westerblad, H. (2002). Recent advances in the understanding of skeletal muscle fatigue. Current Opinion In Rheumatology, 14(6), 648-652.

2001

  • Ju, Y., Allen, D. (2001). Does Ca2+ release from the sarcoplasmic reticulum influence heart rate? Clinical and Experimental Pharmacology and Physiology, 28, 703-708.
  • Allen, D. (2001). Eccentric Muscle damage: mechanisms of early reduction of force. Acta Physiologica, 171, 311-319.
  • Allen, D., Xiao, X. (2001). Na+ entry during ischemia, reperfusion and preconditioning. Cardiovascular Research, 50, 164-166.
  • Allen, D., Westerblad, H. (2001). Role of Phosphate and calcium stores in muscle fatigue. The Journal of Physiology, 536.3, 657-665.
  • Kabbara, A., Allen, D. (2001). The use of the inidicator fluo-FN to measure sarcoplasmic reticulum calcium in single muslce fibres of the cane toad. The Journal of Physiology, 534.1, 87-97.

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