Associate Professor David Booth

MS Australia Principal Research Fellow
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone 9845 8498
Fax 9845 9100

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Selected grants

2015

  • Translation of genetic, genomic and transcriptomic discoveries into clinical practice; Booth D; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.

2014

  • Investigating factors that lead to Multiple Sclerosis; Field J, Butzkeuven H, Booth D, Kilpatrick T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • NanoString nCounter Platform; deFazio A, Alexander I, Booth D, Byrne J, Christodoulou J, Clarke C, Cunningham A, George J, Graham J, Harman A, Liddle C, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Targetting early multiple sclerosis with UVB phototherapy; Hart P, Booth D, Kermode A, Nolan D, Lucas R, Carroll W, Cole J; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • How do the Vitamin D Receptor activation genes CYP27B1 and CYP24A1 alter susceptibility to autoimmune diseases?; Booth D, Batten M, Stewart G, Liddle C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Clinical implications of IL7R genotype: from disease risk to disease management; Stewart G, Booth D, Gottlieb D, McKay F, Vucic S, Rajasuriar R; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • The biologic and clinical implications of IL7Ra genotype in multiple sclerosis; Stewart G, Booth D, McKay F; Multiple Sclerosis Research Australia/Investigator Project Grants.

2011

  • Genetic Control of T cell Regulation in MS; Booth D, Stewart G, Vucic S, Heard R; Multiple Sclerosis Research Australia/Investigator Project Grants.
  • The effect of IL28B haplotype on hepatitis C virus infection and treatment response; Booth D, Ahlenstiel G, Stewart G, George J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Fiona McKay Salary Extension; Booth D; Institute for Immunology and Allergy Research/Donation.
  • The use of conditioned dendritic cells to generate an immune response environment of tolerance to alleviate the sypmtoms of multiple sclerosis.; Booth D; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • MSRA Senior Research Fellowship; Booth D; Multiple Sclerosis Research Australia/Research Support.

2009

  • Functional Genomics to Predict and Enhance Response to Interferon; George J, Suppiah V, Kingston D, Bahlo M, Yang J, McKay F, Booth D, Stewart G, Bahlo M; Australian Research Council (ARC)/Linkage Projects (LP).

2006

  • Host factors affecting of Hepatitis C-associated liver disease; Thomas D, George J, Stewart G, Booth D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Molecular response to interferon beta treatment in multiple sclerosis; Arthur J, Stewart G, Heard R, Booth D, Sedger L, Booth D, Stewart G, Heard R; Australian Research Council (ARC)/Linkage Projects (LP).

2005

  • Genes associated with multiple sclerosis; Stewart G, Booth D, Heard R, Compston A; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Roberts, S., Mitchell, J., Leung, R., Booth, D., Bollipo, S., Ostapowicz, G., Sloss, A., McCaughan, G., Dore, G., Thompson, A., George, J., et al (2014). Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: Analysis from the PREDICT and CHARIOT studies. Journal of Gastroenterology and Hepatology, 29(1), 179-184. [More Information]
  • O'Connor, K., Parnell, G., Patrick, E., Ahlenstiel, G., Suppiah, V., van der Poorten, D., Read, S., Leung, R., Douglas, M., Yang, J., Stewart, G., Liddle, C., George, J., Booth, D. (2014). Hepatic metallothionein expression in chronic hepatitis C virus infection is IFNL3 genotype-dependent. Genes and Immunity, 15(2), 88-94. [More Information]
  • O'Connor, K., Ahlenstiel, G., Suppiah, V., Schibeci, S., Ong, A., Leung, R., van der Poorten, D., Douglas, M., Weltman, M., Stewart, G., Liddle, C., George, J., Booth, D. (2014). IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis. Innate Immunity, 20(6), 598-605. [More Information]
  • Eslam, M., Leung, R., Romero-Gomez, M., Mangia, A., Irving, W., Sheridan, D., Spengler, U., Mollison, L., Cheng, W., Bugianesi, E., Douglas, M., Booth, D., George, J., Ahlenstiel, G., et al (2014). IFNL3 polymorphisms predict response to therapy in chronic hepatitis C genotype 2/3 infection. Journal of Hepatology, 61(2), 235-241. [More Information]
  • Parnell, G., Gatt, P., McKay, F., Schibeci, S., Krupa, M., Powell, J., Visscher, P., Montgomery, G., Lechner-Scott, J., Broadley, S., Liddle, C., Vucic, S., Stewart, G., Booth, D., et al (2014). Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season. Multiple Sclerosis Journal, 20(6), 675-685. [More Information]
  • Parnell, G., Gatt, P., Krupa, M., Dorothee, N., McKay, F., Schibeci, S., Batten, M., Baranzini, S., Henderson, A., Barnett, M., Vucic, S., Stewart, G., Booth, D., et al (2014). The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clinical Immunology, 151(1), 16-24. [More Information]
  • Shahijanian, F., Parnell, G., McKay, F., Gatt, P., Shojaei, M., O'Connor, K., Schibeci, S., Brilot-Turville, F., Liddle, C., Batten, M., Stewart, G., Booth, D. (2014). The CYP27B1 variant associated with increased risk of autoimmune disease is underexpressed in tolerising dendritic cells. Human Molecular Genetics, 23(6), 1425-1434. [More Information]
  • Mechelli, R., Umeton, R., Policano, C., Annibali, V., Coarelli, G., Ricigliano, V., Vittori, D., Fornasiero, A., Buscarinu, M., Booth, D., et al (2013). A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis. PLoS One, 8(5), 1-9. [More Information]
  • Beecham, A., Patsopoulos, N., Xifara, D., Davis, M., Kempinnen, A., Cotsapas, C., Shah, T., Spencer, C., Booth, D., Goris, A., Vucic, S., Stewart, G., et al (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics, 45(11), 1353-1362. [More Information]
  • Suppiah, V., Armstrong, N., O'Connor, K., Berg, T., Weltman, M., Abate, M., Spengler, U., Bassendine, M., Dore, G., Irving, W., Stewart, G., George, J., Booth, D., Ahlenstiel, G., et al (2013). CCR5-Delta32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection. Genes and Immunity, 14(5), 286-290. [More Information]
  • Mohammad, M., Hassanpour, M., Tsai, V., Li, H., Ruitenberg, M., Booth, D., Serrats, J., Hart, P., Symonds, G., Sawchenko, P., et al (2013). Dendritic cells and multiple sclerosis: disease, tolerance and therapy. International Journal of Molecular Sciences, 14(1), 547-562. [More Information]
  • Booth, D. (2013). Do pathogens contribute to multiple sclerosis aetiology? Microbiology Australia, 2013, 144-146.
  • Petta, S., Rosso, C., Leung, R., Abate, M., Booth, D., Solomone, F., Gambino, R., Rizzetto, M., Caviglia, P., Smedile, A., George, J., et al (2013). Effects of IL28B rs12979860 CC Genotype on Metabolic Profile and Sustained Virologic Response in Patients with Genotype 1 Chronic Hepatitis C. Clinical Gastroenterology and Hepatology, 11(3), 311-317. [More Information]
  • Lee, S., Harold, D., Nyholt, D., Goddard, M., Zondervan, K., Williams, J., Montgomery, G., Wray, N., Visscher, P., Scott, R., Booth, D., Stewart, G., Heard, R., et al (2013). Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Human Molecular Genetics, 22(4), 832-841. [More Information]
  • Patsopoulos, N., Barcellos, L., Hintzen, R., Schaefer, C., van Duijn, C., Noble, J., Raj, T., Booth, D., Stewart, G., Heard, R., et al (2013). Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS One, 9(11), 1-10. [More Information]
  • Parnell, G., Tang, B., Nalos, M., Armstrong, N., Huang, S., Booth, D., McLean, A. (2013). Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions. Shock (Philadelphia), 40(3), 166-174. [More Information]
  • Lin, R., Charlesworth, J., Stankovich, J., Perreau, V., Brown, M., Taylor, B., Baxter, A., Kermode, A., Bahlo, M., Booth, D., Stewart, G., Barnett, M., Heard, R., et al (2013). Identity-by-Descent Mapping to Detect Rare Variants Conferring Susceptibility to Multiple Sclerosis. PLoS One, 8(3), 1-8. [More Information]
  • McKay, F., Hoe, E., Parnell, G., Gatt, P., Schibeci, S., Stewart, G., Booth, D. (2013). IL7Ralpha Expression and Upregulation by IFNbeta in Dendritic Cell Subsets Is Haplotype-Dependent. PLoS One, 8(10), 1-10. [More Information]
  • Eslam, M., Booth, D., George, J., Ahlenstiel, G. (2013). Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection. World Journal of Gastroenterology, 19(41), 7055-7061. [More Information]
  • Booth, D., George, J. (2013). Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C. Nature Genetics, 45(2), 119-120. [More Information]
  • Lill, C., Schjeide, B., Graetz, C., Ban, M., Alcina, A., Ortiz, M., Perez, J., Damotte, V., Booth, D., de Lapuente, A., Stewart, G., et al (2013). MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. Brain, 136(6), 1778-1782. [More Information]
  • Baranzini, S., Khankhanian, P., Patsopoulos, N., Li, M., Stankovich, J., Cotsapas, C., Bach Søndergaard, H., Ban, M., Booth, D., Stewart, G., et al (2013). Network-Based Multiple Sclerosis Pathway Analysis with GWAS Data from 15,000 Cases and 30,000 Controls. American Journal of Human Genetics, 92, 854-865. [More Information]
  • Mero, I., Gustavsen, M., Sæther, H., Fla ̊ m, S., Berg-Hansen, P., Søndergaard, H., Jensen, P., Berge, T., Bjølgerud, A., et al, et al (2013). Oligoclonal Band Status in Scandinavian Multiple Sclerosis Patients Is Associated with Specific Genetic Risk Alleles. PLoS One, 8(3), e58352-e58352. [More Information]
  • Cortes, A., Field, J., Glazov, E., Hadler, J., Stankovich, J., Brown, M., Baxter, A., Kermode, A., Taylor, B., Booth, D., Stewart, G., Vucic, S., et al (2013). Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes. Human Molecular Genetics, 22(11), 2283-2292. [More Information]
  • Parnell, G., McLean, A., Booth, D., Armstrong, N., Nalos, M., Huang, S., Manak, J., Tang, W., Tam, O., Chan, S., Tang, B. (2012). A distinct influenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia. Critical Care, 16(4), 1-12. [More Information]
  • Martinelli-Boneschi, F., Esposito, F., Brambilla, P., Lindstrom, E., Lavorgna, G., Stankovich, J., Rodegher, M., Capra, R., Ghezzi, A., Coniglio, G., Booth, D., Stewart, G., et al (2012). A genome-wide association study in progressive multiple sclerosis. Multiple Sclerosis Journal, 18(10), 1384-1394. [More Information]
  • Fischer, J., Bohm, S., Scholz, M., Muller, T., Witt, H., George, J., Sarrazin, C., Susser, S., Schott, E., Suppiah, V., Booth, D., Stewart, G., et al (2012). Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection. Hepatology, 55(6), 1700-1710. [More Information]
  • Patin, E., Kutalik, Z., Guergnon, J., Bibert, S., Nalpas, B., Jouanguy, E., Munteanu, M., Bousquet, L., Argiro, L., Halfon, P., Suppiah, V., Stewart, G., Booth, D., George, J., et al (2012). Genome-Wide Association Study Identifies Variants Associated With Progression of Liver Fibrosis From HCV Infection. Gastroenterology, 143(5), 1244-1252. [More Information]
  • Booth, D., Ahlenstiel, G., George, J. (2012). Pharmacogenomics of hepatitis C infections: personalizing therapy. Genome Medicine, 4(12), 1-10. [More Information]
  • Rajasuriar, R., Booth, D., Gouillou, M., Spelman, T., James, I., Solomon, A., Chua, K., Stewart, G., Deeks, S., Bangsberg, D., et al (2012). The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART. Genes and Immunity, 13(1), 83-93. [More Information]
  • Suan, D., Booth, D., Kennedy, I., Downie, J., Earls, P., Gottlieb, D., Stewart, G., Ling, M. (2012). Vitreal deposits in Val71Ala transthyretin amyloidosis. Internal Medicine Journal, 42(1), 106-108. [More Information]
  • Ahlenstiel, G., Booth, D., George, J. (2012). Will IL28B polymorphisms remain relevant to direct-acting antiviral treatment paradigms? Antiviral Therapy, 17(6 Pt B), 1163-1170. [More Information]
  • Parnell, G., McLean, A., Booth, D., Huang, S., Nalos, M., Tang, B. (2011). Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection – A Meta-Analysis of Genomic Signatures in Circulating Leukocytes. PLoS One, 6(3), e17186-1-e17186-10. [More Information]
  • Ahlenstiel, G., Booth, D., George, J. (2011). Clinical significance of IL28B gene variation in hepatitis C virus infection. Hot Topics in viral Hepatitis, (20), 17-24. [More Information]
  • Sawcer, S., Hallenthal, G., Pirinen, M., Spencer, C., Patsopoulos, N., Moutsianas, L., Dilthey, A., Su, Z., et al, Booth, D., Heard, R., Stewart, G. (2011). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature, 476(7359), 214-219. [More Information]
  • Patsopoulos, N., Esposito, F., Reischl, J., Lehr, S., Bauer, D., Heubach, J., Sandbrink, R., Pohl, C., Edan, G., Kappos, L., Booth, D., et al (2011). Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Annals of Neurology, 70(6), 897-912. [More Information]
  • Afdhal, N., McHutchison, J., Zeuzem, S., Mangia, A., Pawlotsky, J., Murray, J., Shianna, K., Tanaka, Y., Thomas, D., Booth, D., et al (2011). Hepatitis C Pharmacogenetics: State of the Art in 2010. Hepatology, 53(1), 336-345. [More Information]
  • Smith, K., Suppiah, V., O'Connor, K., Berg, T., Weltman, M., Abate, M., Spengler, U., Bassendine, M., Matthews, G., Irving, W., Ahlenstiel, G., Stewart, G., George, J., Booth, D., et al (2011). Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort. Genome Medicine, 3(8), 57-1-57-13. [More Information]
  • Suppiah, V., Gaudieri, S., Armstrong, N., O'Connor, K., Berg, T., Weltman, M., Abate, M., Spengler, U., Bassendine, M., Dore, G., Ahlenstiel, G., Stewart, G., George, J., Booth, D., et al (2011). IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study. PLoS Medicine, 8(9), e1001092-1-e1001092-8. [More Information]
  • Cunningham, A., Booth, D. (2011). The first common cold sore susceptibility gene. The Journal of Infectious Diseases, 204(11), 1645-1647. [More Information]
  • Suan, D., O'Connor, K., Booth, D., Liddle, C., Stewart, G. (2011). Voriconazole toxicity related to polymorphisms in CYP2C19. Internal Medicine Journal, 41(4), 364-365. [More Information]
  • Field, J., Browning, S., Johnson, L., Danoy, P., Varney, M., Tait, B., Gandhi, K., Charlesworth, J., Heard, R., The Australia and New Zealand Multiple Sclerosis Genetics Consortium, (., Stewart, G., Booth, D., et al (2010). A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis. PLoS One, 5(10, Article number e13454), e13454 - 1-e13454 - 7. [More Information]
  • Riveros, C., Mellor, D., Gandhi, K., McKay, F., Cox, M., Berretta, R., Vaezpour, S., Inostroza-Ponta, M., Broadley, S., Heard, R., Vucic, S., Stewart, G., Booth, D., et al (2010). A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis. PLoS One, 5(12), e14176-1-e14176-28. [More Information]
  • Rajasuriar, R., Booth, D., Solomon, A., Chua, K., Spelman, T., Gouillou, M., Schlub, T., Davenport, M., Crowe, S., Elliot, J., Stewart, G., et al (2010). Biological Determinants of Immune Reconstitution in HIV-Infected Patients Receiving Antiretroviral Therapy: The Role of Interleukin 7 and Interleukin 7 Receptor alpha and Microbial Translocation. The Journal of Infectious Diseases, 202(8), 1254-1264. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Gandhi, K., Heard, R., Stewart, G., Booth, D. (2010). Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. Journal of Immunology, 184(5), 2512-2517. [More Information]
  • Esposito, F., Patsopolous, N., Cepok, S., Kockum, J., Leppa, V., Booth, D., Heard, R., Stewart, G., Cox, M., Scott, R., et al (2010). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes and Immunity, 11(5), 397-405. [More Information]
  • Ahlenstiel, G., Booth, D., George, J. (2010). IL28B in hepatitis C virus infection: translating pharmacogenomics into clinical practice. Journal of Gastroenterology and Hepatology, 45(9), 903-910. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2010). Interleukin 7 Receptor Alpha Chain (IL-7Ralpha) Haplotypes Vary in Their Influence on Multiple Sclerosis Susceptibility and Response to Interferon Beta. Journal of Interferon and Cytokine Research, 30(5), 291-298. [More Information]
  • Booth, D., Heard, R., Stewart, G., Cox, M., Scott, R., Lechner-Scott, J., Goris, A., Dobosi, R., Dubois, B., Saarela, J., et al (2010). Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics, 42(6), 469-470. [More Information]
  • Cox, M., Cairns, M., Gandhi, K., Carroll, A., Moscovis, S., Stewart, G., Broadley, S., Scott, R., Booth, D., Lechner-Scott, J., et al (2010). MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood. PLoS One, 5(8), e12132 - 1-e12132 - 7. [More Information]
  • Gandhi, K., McKay, F., Diefenbach, E., Crossett, B., Schibeci, S., Heard, R., Stewart, G., Booth, D., Arthur, J. (2010). Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis. PLoS One, 5(5), e10484 - 1-e10484 - 9. [More Information]
  • Grebely, J., Petoumenos, K., Hellard, M., Matthews, G., Suppiah, V., Applegate, T., Yeung, B., Marks, P., Rawlinson, W., Lloyd, A., Booth, D., George, J., et al (2010). Potential Role for Interleukin-28B Genotype in Treatment Decision-Making in Recent Hepatitis C Virus Infection. Hepatology, 52(4), 1216-1224. [More Information]
  • Gandhi, K., McKay, F., Cox, M., Riveros, C., Armstrong, N., Heard, R., Vucic, S., Williams, D., Stankovich, J., Brown, M., Stewart, G., Booth, D., et al (2010). The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Human Molecular Genetics, 19(11), 2134-2143. [More Information]
  • Booth, D. (2009). An 82-year-old woman with intermittent claudication. Medicine Today, 10(4), 72-73.
  • Bahlo, M., Booth, D., Broadley, S., Brown, M., Foote, S., Griffiths, L., Kilpatrick, T., Lechner-Scott, J., Moscato, P., Perreau, V., Stewart, G., Wiley, J., et al (2009). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics, 41(7), 824-830.
  • Suppiah, V., Moldovan, M., Ahlenstiel, G., Berg, T., Weltman, M., Abate, M., Bassendine, M., Spengler, U., Dore, G., Powell, E., Stewart, G., Booth, D., George, J., et al (2009). IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nature Genetics, 41(10), 1100-1104. [More Information]
  • Ban, M., Goris, A., Lorentzen, A., Baker, A., Mihalova, T., Ingram, G., Booth, D., Heard, R., Stewart, G., Bogaert, E., et al (2009). Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal of Human Genetics, 17, 1309-1313. [More Information]
  • De Jager, P., Baecher-Allan, C., Maier, L., Arthur, A., Ottoboni, L., Barcellos, L., McCauley, J., Sawcer, S., Goris, A., Saarela, J., Booth, D., Stewart, G., et al (2009). The role of the CD58 locus in multiple sclerosis. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 106(13), 5264-5269. [More Information]
  • Gandhi, K., McKay, F., Schibeci, S., Arthur, J., Heard, R., Stewart, G., Booth, D. (2008). BAFF is a Biological Response Marker to IFN-beta Treatment in Multiple Sclerosis. Journal of Interferon and Cytokine Research, 28(9), 529-540. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2008). CD127 immunophenotyping suggests altered CD4(+) T cell regulation in primary progressive multiple sclerosis. Journal of Autoimmunity, 31(1), 52-58. [More Information]
  • Arthur, A., Armati, P., Bye, C., The Southern MS Genetics Consortium, N., Heard, R., Stewart, G., Pollard, J., Booth, D. (2008). Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Medical Genetics, 9(17), 1-12. [More Information]
  • Burfoot, R., Jensen, C., Field, J., Stankovich, J., Varney, M., Johnson, L., Butzkueven, H., Booth, D., Bahlo, M., Tait, B., Heard, R., Stewart, G., et al (2008). SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. Tissue Antigens: immune response genetics, 71(1), 42-50. [More Information]
  • Hensiek, A., Seaman, S., Barcellos, L., Oturai, A., Eraksoi, M., Cocco, E., Vecsei, L., Stewart, G., Dubois, B., Bellman-Strobl, J., Booth, D., et al (2007). Familial effects on the clinical course of multiple sclerosis. Neurology, 68(5), 376-383. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2007). Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes and Immunity, 9((accepted 6 September, 2007)), 1-6. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Rubio, J., Stewart, G. (2006). An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians. BMC Medical Genetics, 7, 64-64. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2006). An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians. Multiple Sclerosis: clinical and laboratory research, 12(6), 710-722. [More Information]
  • McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2006). Analysis of neutralizing antibodies to therapeutic interferon-beta in multiple sclerosis patients: a comparison of three methods in a large Australasian cohort. Journal of Immunological Methods, 310(1-2), 20-29. [More Information]
  • Lachmann, J., Sengul, B., Yavuzsen, T., Booth, D., Booth, S., Bybee, A., Gallimore, J., Soyturk, M., Akar, S., Tunca, M., et al (2006). Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Print Edition), 45(6), 746-750. [More Information]
  • Sawcer, S., Ban, M., Maranian, M., Yeo, T., Compston, A., Kirby, A., Daly, M., De Jager, P., Walsh, E., Heard, R., Stewart, G., Booth, D., et al (2005). A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Burgner, D., Stewart, G. (2005). An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients. European Journal of Human Genetics, 13(7), 815-822. [More Information]
  • Booth, D., Arthur, A., Teutsch, S., Bye, C., Rubio, J., Armati, P., Pollard, J., Heard, R., Stewart, G. (2005). Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. Journal of Molecular Medicine. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Guerin, J., Kaldor, J., Stewart, G. (2004). Analysis Of The Ccl3-L1 Gene For Association With Hiv-1 Susceptibility And Disease Progression. AIDS, 18(7), 1069-1071.
  • Ban, M., Sawcer, S., Heard, R., Bennetts, B., Adams, S., Booth, D., Perich, V., Setakis, E., Compston, A., Stewart, G. (2003). A genome-wide screen for linkage disequilibrium in Australian HLA-DRB1*1501 positive multiple sclerosis patients. Journal of Neuroimmunology, 143(1-2), 60-64. [More Information]
  • Teutsch, S., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2003). Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis. European Journal of Human Genetics, 11(7), 509-515.
  • Esposito, G., Garcia, J., Mangione, P., Giorgetti, S., Corazza, A., Viglino, P., Chiti, F., Andreola, A., Dumy, P., Booth, D., et al (2003). Structural and folding dynamic properties of the T70N variant of human lysozyme. Journal of Biological Chemistry, 278(28), 25910-25918. [More Information]

2014

  • Roberts, S., Mitchell, J., Leung, R., Booth, D., Bollipo, S., Ostapowicz, G., Sloss, A., McCaughan, G., Dore, G., Thompson, A., George, J., et al (2014). Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: Analysis from the PREDICT and CHARIOT studies. Journal of Gastroenterology and Hepatology, 29(1), 179-184. [More Information]
  • O'Connor, K., Parnell, G., Patrick, E., Ahlenstiel, G., Suppiah, V., van der Poorten, D., Read, S., Leung, R., Douglas, M., Yang, J., Stewart, G., Liddle, C., George, J., Booth, D. (2014). Hepatic metallothionein expression in chronic hepatitis C virus infection is IFNL3 genotype-dependent. Genes and Immunity, 15(2), 88-94. [More Information]
  • O'Connor, K., Ahlenstiel, G., Suppiah, V., Schibeci, S., Ong, A., Leung, R., van der Poorten, D., Douglas, M., Weltman, M., Stewart, G., Liddle, C., George, J., Booth, D. (2014). IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis. Innate Immunity, 20(6), 598-605. [More Information]
  • Eslam, M., Leung, R., Romero-Gomez, M., Mangia, A., Irving, W., Sheridan, D., Spengler, U., Mollison, L., Cheng, W., Bugianesi, E., Douglas, M., Booth, D., George, J., Ahlenstiel, G., et al (2014). IFNL3 polymorphisms predict response to therapy in chronic hepatitis C genotype 2/3 infection. Journal of Hepatology, 61(2), 235-241. [More Information]
  • Parnell, G., Gatt, P., McKay, F., Schibeci, S., Krupa, M., Powell, J., Visscher, P., Montgomery, G., Lechner-Scott, J., Broadley, S., Liddle, C., Vucic, S., Stewart, G., Booth, D., et al (2014). Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season. Multiple Sclerosis Journal, 20(6), 675-685. [More Information]
  • Parnell, G., Gatt, P., Krupa, M., Dorothee, N., McKay, F., Schibeci, S., Batten, M., Baranzini, S., Henderson, A., Barnett, M., Vucic, S., Stewart, G., Booth, D., et al (2014). The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clinical Immunology, 151(1), 16-24. [More Information]
  • Shahijanian, F., Parnell, G., McKay, F., Gatt, P., Shojaei, M., O'Connor, K., Schibeci, S., Brilot-Turville, F., Liddle, C., Batten, M., Stewart, G., Booth, D. (2014). The CYP27B1 variant associated with increased risk of autoimmune disease is underexpressed in tolerising dendritic cells. Human Molecular Genetics, 23(6), 1425-1434. [More Information]

2013

  • Mechelli, R., Umeton, R., Policano, C., Annibali, V., Coarelli, G., Ricigliano, V., Vittori, D., Fornasiero, A., Buscarinu, M., Booth, D., et al (2013). A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis. PLoS One, 8(5), 1-9. [More Information]
  • Beecham, A., Patsopoulos, N., Xifara, D., Davis, M., Kempinnen, A., Cotsapas, C., Shah, T., Spencer, C., Booth, D., Goris, A., Vucic, S., Stewart, G., et al (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics, 45(11), 1353-1362. [More Information]
  • Suppiah, V., Armstrong, N., O'Connor, K., Berg, T., Weltman, M., Abate, M., Spengler, U., Bassendine, M., Dore, G., Irving, W., Stewart, G., George, J., Booth, D., Ahlenstiel, G., et al (2013). CCR5-Delta32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection. Genes and Immunity, 14(5), 286-290. [More Information]
  • Mohammad, M., Hassanpour, M., Tsai, V., Li, H., Ruitenberg, M., Booth, D., Serrats, J., Hart, P., Symonds, G., Sawchenko, P., et al (2013). Dendritic cells and multiple sclerosis: disease, tolerance and therapy. International Journal of Molecular Sciences, 14(1), 547-562. [More Information]
  • Booth, D. (2013). Do pathogens contribute to multiple sclerosis aetiology? Microbiology Australia, 2013, 144-146.
  • Petta, S., Rosso, C., Leung, R., Abate, M., Booth, D., Solomone, F., Gambino, R., Rizzetto, M., Caviglia, P., Smedile, A., George, J., et al (2013). Effects of IL28B rs12979860 CC Genotype on Metabolic Profile and Sustained Virologic Response in Patients with Genotype 1 Chronic Hepatitis C. Clinical Gastroenterology and Hepatology, 11(3), 311-317. [More Information]
  • Lee, S., Harold, D., Nyholt, D., Goddard, M., Zondervan, K., Williams, J., Montgomery, G., Wray, N., Visscher, P., Scott, R., Booth, D., Stewart, G., Heard, R., et al (2013). Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Human Molecular Genetics, 22(4), 832-841. [More Information]
  • Patsopoulos, N., Barcellos, L., Hintzen, R., Schaefer, C., van Duijn, C., Noble, J., Raj, T., Booth, D., Stewart, G., Heard, R., et al (2013). Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS One, 9(11), 1-10. [More Information]
  • Parnell, G., Tang, B., Nalos, M., Armstrong, N., Huang, S., Booth, D., McLean, A. (2013). Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions. Shock (Philadelphia), 40(3), 166-174. [More Information]
  • Lin, R., Charlesworth, J., Stankovich, J., Perreau, V., Brown, M., Taylor, B., Baxter, A., Kermode, A., Bahlo, M., Booth, D., Stewart, G., Barnett, M., Heard, R., et al (2013). Identity-by-Descent Mapping to Detect Rare Variants Conferring Susceptibility to Multiple Sclerosis. PLoS One, 8(3), 1-8. [More Information]
  • McKay, F., Hoe, E., Parnell, G., Gatt, P., Schibeci, S., Stewart, G., Booth, D. (2013). IL7Ralpha Expression and Upregulation by IFNbeta in Dendritic Cell Subsets Is Haplotype-Dependent. PLoS One, 8(10), 1-10. [More Information]
  • Eslam, M., Booth, D., George, J., Ahlenstiel, G. (2013). Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection. World Journal of Gastroenterology, 19(41), 7055-7061. [More Information]
  • Booth, D., George, J. (2013). Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C. Nature Genetics, 45(2), 119-120. [More Information]
  • Lill, C., Schjeide, B., Graetz, C., Ban, M., Alcina, A., Ortiz, M., Perez, J., Damotte, V., Booth, D., de Lapuente, A., Stewart, G., et al (2013). MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. Brain, 136(6), 1778-1782. [More Information]
  • Baranzini, S., Khankhanian, P., Patsopoulos, N., Li, M., Stankovich, J., Cotsapas, C., Bach Søndergaard, H., Ban, M., Booth, D., Stewart, G., et al (2013). Network-Based Multiple Sclerosis Pathway Analysis with GWAS Data from 15,000 Cases and 30,000 Controls. American Journal of Human Genetics, 92, 854-865. [More Information]
  • Mero, I., Gustavsen, M., Sæther, H., Fla ̊ m, S., Berg-Hansen, P., Søndergaard, H., Jensen, P., Berge, T., Bjølgerud, A., et al, et al (2013). Oligoclonal Band Status in Scandinavian Multiple Sclerosis Patients Is Associated with Specific Genetic Risk Alleles. PLoS One, 8(3), e58352-e58352. [More Information]
  • Cortes, A., Field, J., Glazov, E., Hadler, J., Stankovich, J., Brown, M., Baxter, A., Kermode, A., Taylor, B., Booth, D., Stewart, G., Vucic, S., et al (2013). Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes. Human Molecular Genetics, 22(11), 2283-2292. [More Information]

2012

  • Parnell, G., McLean, A., Booth, D., Armstrong, N., Nalos, M., Huang, S., Manak, J., Tang, W., Tam, O., Chan, S., Tang, B. (2012). A distinct influenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia. Critical Care, 16(4), 1-12. [More Information]
  • Martinelli-Boneschi, F., Esposito, F., Brambilla, P., Lindstrom, E., Lavorgna, G., Stankovich, J., Rodegher, M., Capra, R., Ghezzi, A., Coniglio, G., Booth, D., Stewart, G., et al (2012). A genome-wide association study in progressive multiple sclerosis. Multiple Sclerosis Journal, 18(10), 1384-1394. [More Information]
  • Fischer, J., Bohm, S., Scholz, M., Muller, T., Witt, H., George, J., Sarrazin, C., Susser, S., Schott, E., Suppiah, V., Booth, D., Stewart, G., et al (2012). Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection. Hepatology, 55(6), 1700-1710. [More Information]
  • Patin, E., Kutalik, Z., Guergnon, J., Bibert, S., Nalpas, B., Jouanguy, E., Munteanu, M., Bousquet, L., Argiro, L., Halfon, P., Suppiah, V., Stewart, G., Booth, D., George, J., et al (2012). Genome-Wide Association Study Identifies Variants Associated With Progression of Liver Fibrosis From HCV Infection. Gastroenterology, 143(5), 1244-1252. [More Information]
  • Booth, D., Ahlenstiel, G., George, J. (2012). Pharmacogenomics of hepatitis C infections: personalizing therapy. Genome Medicine, 4(12), 1-10. [More Information]
  • Rajasuriar, R., Booth, D., Gouillou, M., Spelman, T., James, I., Solomon, A., Chua, K., Stewart, G., Deeks, S., Bangsberg, D., et al (2012). The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART. Genes and Immunity, 13(1), 83-93. [More Information]
  • Suan, D., Booth, D., Kennedy, I., Downie, J., Earls, P., Gottlieb, D., Stewart, G., Ling, M. (2012). Vitreal deposits in Val71Ala transthyretin amyloidosis. Internal Medicine Journal, 42(1), 106-108. [More Information]
  • Ahlenstiel, G., Booth, D., George, J. (2012). Will IL28B polymorphisms remain relevant to direct-acting antiviral treatment paradigms? Antiviral Therapy, 17(6 Pt B), 1163-1170. [More Information]

2011

  • Parnell, G., McLean, A., Booth, D., Huang, S., Nalos, M., Tang, B. (2011). Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection – A Meta-Analysis of Genomic Signatures in Circulating Leukocytes. PLoS One, 6(3), e17186-1-e17186-10. [More Information]
  • Ahlenstiel, G., Booth, D., George, J. (2011). Clinical significance of IL28B gene variation in hepatitis C virus infection. Hot Topics in viral Hepatitis, (20), 17-24. [More Information]
  • Sawcer, S., Hallenthal, G., Pirinen, M., Spencer, C., Patsopoulos, N., Moutsianas, L., Dilthey, A., Su, Z., et al, Booth, D., Heard, R., Stewart, G. (2011). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature, 476(7359), 214-219. [More Information]
  • Patsopoulos, N., Esposito, F., Reischl, J., Lehr, S., Bauer, D., Heubach, J., Sandbrink, R., Pohl, C., Edan, G., Kappos, L., Booth, D., et al (2011). Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Annals of Neurology, 70(6), 897-912. [More Information]
  • Afdhal, N., McHutchison, J., Zeuzem, S., Mangia, A., Pawlotsky, J., Murray, J., Shianna, K., Tanaka, Y., Thomas, D., Booth, D., et al (2011). Hepatitis C Pharmacogenetics: State of the Art in 2010. Hepatology, 53(1), 336-345. [More Information]
  • Smith, K., Suppiah, V., O'Connor, K., Berg, T., Weltman, M., Abate, M., Spengler, U., Bassendine, M., Matthews, G., Irving, W., Ahlenstiel, G., Stewart, G., George, J., Booth, D., et al (2011). Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort. Genome Medicine, 3(8), 57-1-57-13. [More Information]
  • Suppiah, V., Gaudieri, S., Armstrong, N., O'Connor, K., Berg, T., Weltman, M., Abate, M., Spengler, U., Bassendine, M., Dore, G., Ahlenstiel, G., Stewart, G., George, J., Booth, D., et al (2011). IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study. PLoS Medicine, 8(9), e1001092-1-e1001092-8. [More Information]
  • Cunningham, A., Booth, D. (2011). The first common cold sore susceptibility gene. The Journal of Infectious Diseases, 204(11), 1645-1647. [More Information]
  • Suan, D., O'Connor, K., Booth, D., Liddle, C., Stewart, G. (2011). Voriconazole toxicity related to polymorphisms in CYP2C19. Internal Medicine Journal, 41(4), 364-365. [More Information]

2010

  • Field, J., Browning, S., Johnson, L., Danoy, P., Varney, M., Tait, B., Gandhi, K., Charlesworth, J., Heard, R., The Australia and New Zealand Multiple Sclerosis Genetics Consortium, (., Stewart, G., Booth, D., et al (2010). A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis. PLoS One, 5(10, Article number e13454), e13454 - 1-e13454 - 7. [More Information]
  • Riveros, C., Mellor, D., Gandhi, K., McKay, F., Cox, M., Berretta, R., Vaezpour, S., Inostroza-Ponta, M., Broadley, S., Heard, R., Vucic, S., Stewart, G., Booth, D., et al (2010). A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis. PLoS One, 5(12), e14176-1-e14176-28. [More Information]
  • Rajasuriar, R., Booth, D., Solomon, A., Chua, K., Spelman, T., Gouillou, M., Schlub, T., Davenport, M., Crowe, S., Elliot, J., Stewart, G., et al (2010). Biological Determinants of Immune Reconstitution in HIV-Infected Patients Receiving Antiretroviral Therapy: The Role of Interleukin 7 and Interleukin 7 Receptor alpha and Microbial Translocation. The Journal of Infectious Diseases, 202(8), 1254-1264. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Gandhi, K., Heard, R., Stewart, G., Booth, D. (2010). Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. Journal of Immunology, 184(5), 2512-2517. [More Information]
  • Esposito, F., Patsopolous, N., Cepok, S., Kockum, J., Leppa, V., Booth, D., Heard, R., Stewart, G., Cox, M., Scott, R., et al (2010). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes and Immunity, 11(5), 397-405. [More Information]
  • Ahlenstiel, G., Booth, D., George, J. (2010). IL28B in hepatitis C virus infection: translating pharmacogenomics into clinical practice. Journal of Gastroenterology and Hepatology, 45(9), 903-910. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2010). Interleukin 7 Receptor Alpha Chain (IL-7Ralpha) Haplotypes Vary in Their Influence on Multiple Sclerosis Susceptibility and Response to Interferon Beta. Journal of Interferon and Cytokine Research, 30(5), 291-298. [More Information]
  • Booth, D., Heard, R., Stewart, G., Cox, M., Scott, R., Lechner-Scott, J., Goris, A., Dobosi, R., Dubois, B., Saarela, J., et al (2010). Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics, 42(6), 469-470. [More Information]
  • Cox, M., Cairns, M., Gandhi, K., Carroll, A., Moscovis, S., Stewart, G., Broadley, S., Scott, R., Booth, D., Lechner-Scott, J., et al (2010). MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood. PLoS One, 5(8), e12132 - 1-e12132 - 7. [More Information]
  • Gandhi, K., McKay, F., Diefenbach, E., Crossett, B., Schibeci, S., Heard, R., Stewart, G., Booth, D., Arthur, J. (2010). Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis. PLoS One, 5(5), e10484 - 1-e10484 - 9. [More Information]
  • Grebely, J., Petoumenos, K., Hellard, M., Matthews, G., Suppiah, V., Applegate, T., Yeung, B., Marks, P., Rawlinson, W., Lloyd, A., Booth, D., George, J., et al (2010). Potential Role for Interleukin-28B Genotype in Treatment Decision-Making in Recent Hepatitis C Virus Infection. Hepatology, 52(4), 1216-1224. [More Information]
  • Gandhi, K., McKay, F., Cox, M., Riveros, C., Armstrong, N., Heard, R., Vucic, S., Williams, D., Stankovich, J., Brown, M., Stewart, G., Booth, D., et al (2010). The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Human Molecular Genetics, 19(11), 2134-2143. [More Information]

2009

  • Booth, D. (2009). An 82-year-old woman with intermittent claudication. Medicine Today, 10(4), 72-73.
  • Bahlo, M., Booth, D., Broadley, S., Brown, M., Foote, S., Griffiths, L., Kilpatrick, T., Lechner-Scott, J., Moscato, P., Perreau, V., Stewart, G., Wiley, J., et al (2009). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nature Genetics, 41(7), 824-830.
  • Suppiah, V., Moldovan, M., Ahlenstiel, G., Berg, T., Weltman, M., Abate, M., Bassendine, M., Spengler, U., Dore, G., Powell, E., Stewart, G., Booth, D., George, J., et al (2009). IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nature Genetics, 41(10), 1100-1104. [More Information]
  • Ban, M., Goris, A., Lorentzen, A., Baker, A., Mihalova, T., Ingram, G., Booth, D., Heard, R., Stewart, G., Bogaert, E., et al (2009). Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal of Human Genetics, 17, 1309-1313. [More Information]
  • De Jager, P., Baecher-Allan, C., Maier, L., Arthur, A., Ottoboni, L., Barcellos, L., McCauley, J., Sawcer, S., Goris, A., Saarela, J., Booth, D., Stewart, G., et al (2009). The role of the CD58 locus in multiple sclerosis. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 106(13), 5264-5269. [More Information]

2008

  • Gandhi, K., McKay, F., Schibeci, S., Arthur, J., Heard, R., Stewart, G., Booth, D. (2008). BAFF is a Biological Response Marker to IFN-beta Treatment in Multiple Sclerosis. Journal of Interferon and Cytokine Research, 28(9), 529-540. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2008). CD127 immunophenotyping suggests altered CD4(+) T cell regulation in primary progressive multiple sclerosis. Journal of Autoimmunity, 31(1), 52-58. [More Information]
  • Arthur, A., Armati, P., Bye, C., The Southern MS Genetics Consortium, N., Heard, R., Stewart, G., Pollard, J., Booth, D. (2008). Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Medical Genetics, 9(17), 1-12. [More Information]
  • Burfoot, R., Jensen, C., Field, J., Stankovich, J., Varney, M., Johnson, L., Butzkueven, H., Booth, D., Bahlo, M., Tait, B., Heard, R., Stewart, G., et al (2008). SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. Tissue Antigens: immune response genetics, 71(1), 42-50. [More Information]

2007

  • Hensiek, A., Seaman, S., Barcellos, L., Oturai, A., Eraksoi, M., Cocco, E., Vecsei, L., Stewart, G., Dubois, B., Bellman-Strobl, J., Booth, D., et al (2007). Familial effects on the clinical course of multiple sclerosis. Neurology, 68(5), 376-383. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2007). Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes and Immunity, 9((accepted 6 September, 2007)), 1-6. [More Information]

2006

  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Rubio, J., Stewart, G. (2006). An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians. BMC Medical Genetics, 7, 64-64. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2006). An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians. Multiple Sclerosis: clinical and laboratory research, 12(6), 710-722. [More Information]
  • McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2006). Analysis of neutralizing antibodies to therapeutic interferon-beta in multiple sclerosis patients: a comparison of three methods in a large Australasian cohort. Journal of Immunological Methods, 310(1-2), 20-29. [More Information]
  • Lachmann, J., Sengul, B., Yavuzsen, T., Booth, D., Booth, S., Bybee, A., Gallimore, J., Soyturk, M., Akar, S., Tunca, M., et al (2006). Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Print Edition), 45(6), 746-750. [More Information]

2005

  • Sawcer, S., Ban, M., Maranian, M., Yeo, T., Compston, A., Kirby, A., Daly, M., De Jager, P., Walsh, E., Heard, R., Stewart, G., Booth, D., et al (2005). A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Burgner, D., Stewart, G. (2005). An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients. European Journal of Human Genetics, 13(7), 815-822. [More Information]
  • Booth, D., Arthur, A., Teutsch, S., Bye, C., Rubio, J., Armati, P., Pollard, J., Heard, R., Stewart, G. (2005). Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. Journal of Molecular Medicine. [More Information]

2004

  • Bugeja, M., Booth, D., Bennetts, B., Guerin, J., Kaldor, J., Stewart, G. (2004). Analysis Of The Ccl3-L1 Gene For Association With Hiv-1 Susceptibility And Disease Progression. AIDS, 18(7), 1069-1071.

2003

  • Ban, M., Sawcer, S., Heard, R., Bennetts, B., Adams, S., Booth, D., Perich, V., Setakis, E., Compston, A., Stewart, G. (2003). A genome-wide screen for linkage disequilibrium in Australian HLA-DRB1*1501 positive multiple sclerosis patients. Journal of Neuroimmunology, 143(1-2), 60-64. [More Information]
  • Teutsch, S., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2003). Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis. European Journal of Human Genetics, 11(7), 509-515.
  • Esposito, G., Garcia, J., Mangione, P., Giorgetti, S., Corazza, A., Viglino, P., Chiti, F., Andreola, A., Dumy, P., Booth, D., et al (2003). Structural and folding dynamic properties of the T70N variant of human lysozyme. Journal of Biological Chemistry, 278(28), 25910-25918. [More Information]

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