Dr David Bowen

Senior Lecturer
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6264

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Selected grants

2015

  • Unraveling mechanisms of liver transplant tolerance; Bertolino P, Bowen D, McCaughan G, Dwyer K; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Prognostic and mechanistic insights into outcomes of liver transplantation for hepatitis C related liver disease via analysis ofHCV evolution post-transplant; Bowen D, McCaughan G; Sydney Local Health District/Royal Prince Alfred Transplant Institute.

2013

  • Liver-directed MHC gene transfer for the induction of transplantation tolerance; from proof of principle to a robust and clinically-applicable strategy.; Sharland A, Bowen D, Bishop A; RPA Transplant Institute/Research Support.

2012

  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • HCV Immunity Post Liver Transplant; Bowen D, Luciani F, Bull R, Shackel N, Bassendine M; DVC Research/Bridging Support Grant.

2011

  • Deciphering mechanisms of liver allograft tolerance; Bertolino P, Dwyer K, Bowen D, Bishop A; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Next-generation high-speed flow cytometric cell sorter; Fazekas B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Dendritic cell phenotype and function in chronic hepatic C virus infection; Bowen D; Sylvia and Charles Viertel Charitable Foundation/Establishment Grants for Viertel Clinical Investigators.

2008

  • Hepatitis C virus-specific immune responses post-liver transplantation; Bowen D; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Bowen, D. (2012). Immune Responses to HCV: Implications for Therapy. In Geoffrey W. McCaughan, John G. McHutchison, Jean-Michel Pawlotsky (Eds.), Advanced Therapy for Hepatitis C, (pp. 17-24). Chichester, United Kingdom: Wiley-Blackwell Publishing.
  • Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.
  • Bertolino, P., McCaughan, G., Bowen, D. (2008). Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In Emilio Jirillo (Eds.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications, (pp. 39-70). United States: Springer.
  • Bertolino, P., Bowen, D., Zen, M., McCaughan, G. (2005). Autoimmune hepatitis in transgenic mouse models: what lessons can be learnt? In H. P. Dienes, U. Leuschner, A. W. Lohse, M. P. Manns (Eds.), Autoimmune Liver Disease: Proceedings of the Falk Symposium No. 142, (pp. 60-72). The Netherlands: Springer.

Journals

  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Author reply: RE Terlipressin therapy for moderate to severe hyponatraemia in patients with liver failure. Internal Medicine Journal, 43(5), 607-607. [More Information]
  • Tay, S., Lu, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A., Cowan, P., McCaughan, G., Dwyer, K., Bowen, D., et al (2013). Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation. Liver Transplantation, 19(11), 1224-1235. [More Information]
  • Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
  • Bowen, D., Shackel, N. (2013). Hepatitis C Pathogenesis and Outcomes After Liver Transplantation: Probing MicroRNA Expression for New Insights. Liver Transplantation, 19(4), 355-357. [More Information]
  • McCaughan, G., Bowen, D., Bertolino, P. (2013). Operational tolerance in liver transplantation: Shall we predict or promote? Liver Transplantation, 19(9), 933-936. [More Information]
  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Terlipressin Therapy for Moderate to Severe Hyponatremia in Patients with Liver Failure. Internal Medicine Journal, 43(3), 240-246. [More Information]
  • Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012). Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International, 32(10), 1527-1534. [More Information]
  • Bowen, D. (2012). Finding a role for Th17 cells in hepatitis C pathogenesis. Journal of Gastroenterology and Hepatology, 27(2), 188-191. [More Information]
  • Holz, L., Benseler, V., Vo, M., McGuffog, C., Van Rooijen, N., McCaughan, G., Bowen, D., Bertolino, P. (2012). Naive CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2(low) Bim(high) phenotype, poor CTL function and cell death. Journal of Hepatology, 57(4), 830-836. [More Information]
  • Bishop, A., Bertolino, P., Bowen, D., McCaughan, G. (2012). Tolerance in liver transplantation. Best Practice & Research: Clinical Gastroenterology, 26(1), 73-84. [More Information]
  • Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012). Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology, 57(2), 352-358. [More Information]
  • Wood, N., Linn, M., Bowen, D. (2011). Exhausted or just sleeping: Awakening virus-specific responses in chronic hepatitis C virus infection. Hepatology, 54(5), 1879-1882. [More Information]
  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(40), 16735-16740. [More Information]
  • McCaughan, G., Shackel, N., Bowen, D. (2011). Liver transplantation and hepatitis C: will understanding the interleukin-28B polymorphisms improve outcomes? Liver Transplantation, 17(3), 219-221. [More Information]
  • McCaughan, G., Bowen, D. (2011). Pathogenesis of cholestatic hepatitis C. Journal of Hepatology, 54, 392-394. [More Information]
  • Benseler, V., Tay, S., Bowen, D., Bertolino, P. (2011). Role of the Hepatic Parenchyma in Liver Transplant Tolerance: a Paradigm Revisited. Digestive Diseases, 29(4), 391-401. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
  • Holz, L., Bowen, D., Bertolino, P. (2010). Mechanisms of T cell death in the liver: to Bim or not to Bim? Digestive Diseases, 28(1), 14-24. [More Information]
  • Fuller, M., Shoukry, N., Gushima, T., Bowen, D., Callendret, B., Campbell, K., Hasselschwert, D., Hughes, A., Walker, C. (2010). Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology, 51(2), 378-387. [More Information]
  • Shackel, N., Bowen, D., McCaughan, G. (2010). Snipping away at hepatitis C. Hepatology, 51(2), 703-705. [More Information]
  • Bowen, D. (2010). Toward small animal models for the study of human hepatitis viruses. Hepatology, 52(1), 382-388. [More Information]
  • McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
  • Velazquez, V., Bowen, D., Walker, C. (2009). Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy. Blood, 113(3), 538-545. [More Information]
  • Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., D'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008). Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology, 135(3), 989-997. [More Information]
  • Ramalingam, R., Meyer-Olson, D., Shoukry, N., Bowen, D., Walker, C., Kalams, S. (2008). Kinetic analysis by real-time PCR of Hepatitis C Virus (HCV)-specific T cells in peripheral blood and liver after challenge with HCV. Journal of Virology, 82(21), 10487-10492. [More Information]
  • Holz, L., McCaughan, G., Benseler, V., Bertolino, P., Bowen, D. (2008). Liver tolerance and the manipulation of immune outcomes. Inflammation and Allergy: Drug Targets, 7(1), 6-18. [More Information]
  • Bowen, D. (2008). Of mice and molecular mimicry: Modeling autoimmune hepatitis. Hepatology, 48(3), 1013-1015. [More Information]
  • Bowen, D., Shoukry, N., Grakoui, A., Fuller, M., Cawthon, A., Dong, C., Hasselschwert, D., Brasky, K., Freeman, G., Seth, N., et al (2008). Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. Journal of Virology, 82(10), 5109-5114. [More Information]
  • Bertolino, P., Bowen, D., Benseler, V. (2007). T cells in the liver: there is life beyond the graveyard. Hepatology, 45(6), 1580-1582. [More Information]
  • Benseler, V., McCaughan, G., Schlitt, H., Bishop, A., Bowen, D., Bertolino, P. (2007). The liver: a special case in transplantation tolerance. Seminars in Liver Disease, 27(2), 194-213. [More Information]
  • Dahlke, M., Loi, R., Warren, A., Holz, L., Popp, F., Weiss, D., Piso, P., Bowen, D., McCaughan, G., Schlitt, H., Bertolino, P. (2006). Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology, 44(2), 334-341. [More Information]
  • Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]
  • Bowen, D., Walker, C. (2005). Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature, 436(7053), 946-952. [More Information]
  • Bertolino, P., Schrage, A., Bowen, D., Klugewitz, K., Ghani, S., Eulenburg, K., Holz, L., Hogg, N., McCaughan, G., Hamann, A. (2005). Early intrahepatic antigen-specific retention of naïve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology, 42(5), 1063-1071. [More Information]
  • Bowen, D., McCaughan, G., Bertolino, P. (2005). Intrahepatic immunity: a tale of two sites? Trends in Immunology, 26(10), 512-517. [More Information]
  • Bowen, D., Walker, C. (2005). Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man. The Journal of Experimental Medicine, 201(11), 1709-1714. [More Information]
  • Sun, J., Tumurbaatar, B., Jia, J., Diao, H., Bodola, F., Lemon, S., Tang, W., Bowen, D., McCaughan, G., Bertolino, P., et al (2005). Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury. Journal of Virology, 79(16), 10730-10739. [More Information]
  • Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.
  • Bowen, D., Walker, C. (2005). The origin of quasispecies: Cause or consequence of chronic hepatitis C viral infection? Journal of Hepatology, 42(3), 408-417. [More Information]
  • McCaughan, G., Bertolino, P., Bowen, D., Zen, M., Holz, L., Davis, T. (2004). The Site Of Primary T Cell Activation Is A Determinant Of The Balance Between Intrahepatic Tolerance And Immunity. Journal of Clinical Investigation, 114(5), 701-712.
  • Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264.
  • Zekry, A., Bishop, A., Bowen, D., Gleeson, M., Guney, S., Painter, D., McCaughan, G. (2002). Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury. Liver Transplantation, 8(3), 292-301.
  • Yan, Y., Putten, K., Bowen, D., Painter, D., Kohar, J., Sharland, A., McCaughan, G., Bishop, A. (2002). Postoperative administration of donor B cells induces rat kidney allograft acceptance: lack of association with TH2 cytokine expression in long-term accepted grafts. Transplantation, 73(7), 1123-1130.
  • Bertolino, P., McCaughan, G., Bowen, D. (2002). Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'. Immunology and Cell Biology, 80(1), 84-92.
  • Bertolino, P., Bowen, D., McCaughan, G., Fazekas, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.
  • Yan, Y., Shastry, S., Richards, C., Wang, C., Bowen, D., Sharland, A., Painter, D., McCaughan, G., Bishop, A. (2001). Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. Journal of Immunology, 166, 5258-5264.
  • McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191.

2013

  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Author reply: RE Terlipressin therapy for moderate to severe hyponatraemia in patients with liver failure. Internal Medicine Journal, 43(5), 607-607. [More Information]
  • Tay, S., Lu, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A., Cowan, P., McCaughan, G., Dwyer, K., Bowen, D., et al (2013). Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation. Liver Transplantation, 19(11), 1224-1235. [More Information]
  • Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
  • Bowen, D., Shackel, N. (2013). Hepatitis C Pathogenesis and Outcomes After Liver Transplantation: Probing MicroRNA Expression for New Insights. Liver Transplantation, 19(4), 355-357. [More Information]
  • McCaughan, G., Bowen, D., Bertolino, P. (2013). Operational tolerance in liver transplantation: Shall we predict or promote? Liver Transplantation, 19(9), 933-936. [More Information]
  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Terlipressin Therapy for Moderate to Severe Hyponatremia in Patients with Liver Failure. Internal Medicine Journal, 43(3), 240-246. [More Information]

2012

  • Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012). Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International, 32(10), 1527-1534. [More Information]
  • Bowen, D. (2012). Finding a role for Th17 cells in hepatitis C pathogenesis. Journal of Gastroenterology and Hepatology, 27(2), 188-191. [More Information]
  • Bowen, D. (2012). Immune Responses to HCV: Implications for Therapy. In Geoffrey W. McCaughan, John G. McHutchison, Jean-Michel Pawlotsky (Eds.), Advanced Therapy for Hepatitis C, (pp. 17-24). Chichester, United Kingdom: Wiley-Blackwell Publishing.
  • Holz, L., Benseler, V., Vo, M., McGuffog, C., Van Rooijen, N., McCaughan, G., Bowen, D., Bertolino, P. (2012). Naive CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2(low) Bim(high) phenotype, poor CTL function and cell death. Journal of Hepatology, 57(4), 830-836. [More Information]
  • Bishop, A., Bertolino, P., Bowen, D., McCaughan, G. (2012). Tolerance in liver transplantation. Best Practice & Research: Clinical Gastroenterology, 26(1), 73-84. [More Information]
  • Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012). Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology, 57(2), 352-358. [More Information]

2011

  • Wood, N., Linn, M., Bowen, D. (2011). Exhausted or just sleeping: Awakening virus-specific responses in chronic hepatitis C virus infection. Hepatology, 54(5), 1879-1882. [More Information]
  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(40), 16735-16740. [More Information]
  • McCaughan, G., Shackel, N., Bowen, D. (2011). Liver transplantation and hepatitis C: will understanding the interleukin-28B polymorphisms improve outcomes? Liver Transplantation, 17(3), 219-221. [More Information]
  • McCaughan, G., Bowen, D. (2011). Pathogenesis of cholestatic hepatitis C. Journal of Hepatology, 54, 392-394. [More Information]
  • Benseler, V., Tay, S., Bowen, D., Bertolino, P. (2011). Role of the Hepatic Parenchyma in Liver Transplant Tolerance: a Paradigm Revisited. Digestive Diseases, 29(4), 391-401. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]

2010

  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
  • Holz, L., Bowen, D., Bertolino, P. (2010). Mechanisms of T cell death in the liver: to Bim or not to Bim? Digestive Diseases, 28(1), 14-24. [More Information]
  • Fuller, M., Shoukry, N., Gushima, T., Bowen, D., Callendret, B., Campbell, K., Hasselschwert, D., Hughes, A., Walker, C. (2010). Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology, 51(2), 378-387. [More Information]
  • Shackel, N., Bowen, D., McCaughan, G. (2010). Snipping away at hepatitis C. Hepatology, 51(2), 703-705. [More Information]
  • Bowen, D. (2010). Toward small animal models for the study of human hepatitis viruses. Hepatology, 52(1), 382-388. [More Information]

2009

  • McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
  • Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.
  • Velazquez, V., Bowen, D., Walker, C. (2009). Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy. Blood, 113(3), 538-545. [More Information]

2008

  • Bertolino, P., McCaughan, G., Bowen, D. (2008). Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In Emilio Jirillo (Eds.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications, (pp. 39-70). United States: Springer.
  • Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., D'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008). Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology, 135(3), 989-997. [More Information]
  • Ramalingam, R., Meyer-Olson, D., Shoukry, N., Bowen, D., Walker, C., Kalams, S. (2008). Kinetic analysis by real-time PCR of Hepatitis C Virus (HCV)-specific T cells in peripheral blood and liver after challenge with HCV. Journal of Virology, 82(21), 10487-10492. [More Information]
  • Holz, L., McCaughan, G., Benseler, V., Bertolino, P., Bowen, D. (2008). Liver tolerance and the manipulation of immune outcomes. Inflammation and Allergy: Drug Targets, 7(1), 6-18. [More Information]
  • Bowen, D. (2008). Of mice and molecular mimicry: Modeling autoimmune hepatitis. Hepatology, 48(3), 1013-1015. [More Information]
  • Bowen, D., Shoukry, N., Grakoui, A., Fuller, M., Cawthon, A., Dong, C., Hasselschwert, D., Brasky, K., Freeman, G., Seth, N., et al (2008). Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. Journal of Virology, 82(10), 5109-5114. [More Information]

2007

  • Bertolino, P., Bowen, D., Benseler, V. (2007). T cells in the liver: there is life beyond the graveyard. Hepatology, 45(6), 1580-1582. [More Information]
  • Benseler, V., McCaughan, G., Schlitt, H., Bishop, A., Bowen, D., Bertolino, P. (2007). The liver: a special case in transplantation tolerance. Seminars in Liver Disease, 27(2), 194-213. [More Information]

2006

  • Dahlke, M., Loi, R., Warren, A., Holz, L., Popp, F., Weiss, D., Piso, P., Bowen, D., McCaughan, G., Schlitt, H., Bertolino, P. (2006). Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology, 44(2), 334-341. [More Information]
  • Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]

2005

  • Bowen, D., Walker, C. (2005). Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature, 436(7053), 946-952. [More Information]
  • Bertolino, P., Bowen, D., Zen, M., McCaughan, G. (2005). Autoimmune hepatitis in transgenic mouse models: what lessons can be learnt? In H. P. Dienes, U. Leuschner, A. W. Lohse, M. P. Manns (Eds.), Autoimmune Liver Disease: Proceedings of the Falk Symposium No. 142, (pp. 60-72). The Netherlands: Springer.
  • Bertolino, P., Schrage, A., Bowen, D., Klugewitz, K., Ghani, S., Eulenburg, K., Holz, L., Hogg, N., McCaughan, G., Hamann, A. (2005). Early intrahepatic antigen-specific retention of naïve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology, 42(5), 1063-1071. [More Information]
  • Bowen, D., McCaughan, G., Bertolino, P. (2005). Intrahepatic immunity: a tale of two sites? Trends in Immunology, 26(10), 512-517. [More Information]
  • Bowen, D., Walker, C. (2005). Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man. The Journal of Experimental Medicine, 201(11), 1709-1714. [More Information]
  • Sun, J., Tumurbaatar, B., Jia, J., Diao, H., Bodola, F., Lemon, S., Tang, W., Bowen, D., McCaughan, G., Bertolino, P., et al (2005). Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury. Journal of Virology, 79(16), 10730-10739. [More Information]
  • Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.
  • Bowen, D., Walker, C. (2005). The origin of quasispecies: Cause or consequence of chronic hepatitis C viral infection? Journal of Hepatology, 42(3), 408-417. [More Information]

2004

  • McCaughan, G., Bertolino, P., Bowen, D., Zen, M., Holz, L., Davis, T. (2004). The Site Of Primary T Cell Activation Is A Determinant Of The Balance Between Intrahepatic Tolerance And Immunity. Journal of Clinical Investigation, 114(5), 701-712.

2002

  • Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264.
  • Zekry, A., Bishop, A., Bowen, D., Gleeson, M., Guney, S., Painter, D., McCaughan, G. (2002). Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury. Liver Transplantation, 8(3), 292-301.
  • Yan, Y., Putten, K., Bowen, D., Painter, D., Kohar, J., Sharland, A., McCaughan, G., Bishop, A. (2002). Postoperative administration of donor B cells induces rat kidney allograft acceptance: lack of association with TH2 cytokine expression in long-term accepted grafts. Transplantation, 73(7), 1123-1130.
  • Bertolino, P., McCaughan, G., Bowen, D. (2002). Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'. Immunology and Cell Biology, 80(1), 84-92.

2001

  • Bertolino, P., Bowen, D., McCaughan, G., Fazekas, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.
  • Yan, Y., Shastry, S., Richards, C., Wang, C., Bowen, D., Sharland, A., Painter, D., McCaughan, G., Bishop, A. (2001). Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. Journal of Immunology, 166, 5258-5264.

2000

  • McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191.

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