Professor David Cook

Professor
Physiology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9036 3314
Fax +61 2 9036 3316

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Research interests

Professor David I Cook is a leading epithelial transport physiologist who has extensive research track record in investigating cellular mechanisms that regulate of ion channels in the kidney, gut, lung and exocrine glands during normal and disease stages.

ion transport, cystic fibrosis, intracellular cellular signalling

Selected grants

2013

  • ZnT-1 regulates Store Operated Calcium Channels in salivary gland physiology and pathology; Cook D, Moran A, Muallem S; Australian Research Council (ARC)/Discovery Projects (DP).

2011

  • Interaction between H5N1 and the respiratory epithelium; Cook D, Dinudom A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Regulation of epithelial sodium channels by caveolin; Cook D, Dinudom A; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Dietary fats as drivers of obesity-related inflammation; Storlien L, Hunt N, Cook D, Caterson I; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Novel kinases - how do they regulate epithelial ion transport, and what is their role in epithelial function?; Cook D; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • The impact of avian influenza virus on the respiratory epithelium; Cook D; University of Sydney/Bridging Support.
  • Physiological function of Nedd4-2 in regulating the epithelial sodium channel; Kumar S, Cook D; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • The impact of avian influenza virus on respiratory epithelium; Cook D; University of Sydney/Bridging Support.
  • Phospholipids and kinase as regulators of the epithelial sodium channels; Cook D; Australian Research Council (ARC)/Discovery Projects (DP).
  • Relationship between cell-cell interactions and disease severity in patients with cerebral malaria; Grau G, Cook D, Hunt N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Determining the cellular mechanisms involved in the airway response to topical citrate; Middleton P, Cook D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Voltage Clamp System; Cook D; Clive & Vera Ramaciotti Foundation/Clive & Vera Ramaciotti Fndtn.
  • Epithelial ion transport defects in cystic fibrosis; Cook D; Cystic Fibrosis Australia/Research Grant.
  • PHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer research; Halliday G, Ho J, Conigrave A, Iland H, Lee C, Joshua D, Cook D, Richardson D, Reichardt J, Grau G, Lovejoy D, Hunt N, King N, Mason R, Murphy C, Sharland A, Assinder S, Dong Q, Bishop A; Cancer Institute New South Wales/Infrastructure Grant.

2006

  • University of Sydney - Bridging Support Grant; Cook D; University of Sydney/Bridging Support.
  • Carv Ii Confocal Imager; Cook D; Clive & Vera Ramaciotti Foundation/General Grants.
  • Advanced Imaging Flow Cytometry Facility for NSW; King N, Campbell I, Cook D, Black J, Halliday G, McAvoy J, Gunning P, Pollard J, Murray M, Britton W, Dawes I, Khachigian L, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2005

  • Amaxa nucleofector II; Cook D; Clive & Vera Ramaciotti Foundation/Research Grant.
  • Mechanisms of Nedd4/Nedd4-2-mediated regulation of the epithelial sodium channel; Cook D, Dinudom A, Kumar S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • FACS Aria for the University of Sydney Flow Cytometry Facility; King N, Pollard J, Rasko J, Lovicu F, Bishop A, Bertolino P, Briscoe H, Gillies M, Madigan M, McAvoy J, Murphy C, Balcar V, Armour C, Hughes M, Reeve V, Christopherson R, Halliday G, Christie M, Pollock C, McCaughan G, Gorrell M, Dong Q, Abendroth A, Menzies S, Barnetson R, Byrne S, Hunt N, Hambly B, Cook D, Mason R, Day M, Black J; University of Sydney/Equipment Grant.

2004

  • 2-electrode voltage clamp (2EVC) and assessories; Vandenberg R, Mitrovic A, Cook D, Collins M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Fluorimetric imaging equipment; Cook D, Dinudom A; Clive & Vera Ramaciotti Foundation/Research Grant.

2003

  • Regulation of the epithelial sodium channel by cytosolic chloride and proinflammatory cytokines?; Dinudom A, Cook D, Young J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Novel ways of regulating epithelial transport; Cook D, Young J, Dinudom A; Australian Research Council (ARC)/Discovery Projects (DP).

2002

  • Regulation of the epithelial sodium channel by the Nedd4-like protein KIAA0439; Cook D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Molecular basis of G protein receptor-effector coupling in epithelial cells; Cook D, Poronnik P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Regulation of the activity and the surface expression of sodium channels; Cook D, Young J; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Axopatch 200B patch-clamp amplifier; Cook D; Australian Kidney Foundation/Research Grant.
  • Interactions between systems that control sodium channels in renal epithelia; Cook D, Young J; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Intracellular mechanisms controlling sodium channels in salivary duct cells; Cook D, Young J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Electroneutral transport in salivary duct cells; Cook D, Young J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Homocellular regulation in salivary epithelia; Cook D, Young J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Control of epithelial Na+ channels in an absorptive epithelium; Cook D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Studies on the role of ion channels in early embryonic development; Cook D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Equipment to allow simultaneous voltage clamp and confocal microscopy on a single cell; Allen D, Cook D, Bennett M; Clive & Vera Ramaciotti Foundation/Research Grant.
  • Cloning and characterisation of an epithelial protein; Cook D, Wade D, Jazwinska L, Pond S; Johnson and Johnson Research Pty Ltd/BLO Project.
  • Control of Na+ channels in B lymphocytes from normotensive and hypertensive subjects; Cook D; Heart Foundation of Australia/Grants-in-Aid.
  • Control of potassium channels in early mouse embryos; Day M, Cook D; National Health and Medical Research Council (NHMRC)/Project Grants.

1999

  • Nikon fluorescence microscope for visualisation of GEP expressing adenoviruses and fusion proteins; Poronnik P, Cook D; Clive & Vera Ramaciotti Foundation/Research Grants.

Selected publications

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Book Chapters

  • Cook, D., Keech, A., Gebski, V., Pike, R., Wonders, S. (2008). Balancing the outcomes: reporting harms (adverse events). In Anthony Keech, Val Gebski, Rhana Pike (Eds.), Interpreting and reporting clinical trials: a guide to the CONSORT statement and the principles of randomised controlled trials, (pp. 132-142). Sydney: AMPCo.
  • Cook, D., Keech, A., Gebski, V. (2007). Subgroup analysis in clinical trials. In Anthony Keech, Val Gebski, Rhana Pike (Eds.), Interpreting and reporting clinical trials: a guide to the CONSORT statement and the principles of randomised controlled trials, (pp. 105-113). Sydney: AMPCo.
  • Jaeschke, R., Guyatt,, G., Barratt, A., Walters, S., Cook, D., McAlister, F., Attia, J. (2002). Therapy and Understanding the Results: Measures of Association. In Gordon Guyatt & Drummond Rennie (Eds.), Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, (pp. 363-389). United States: American Medical Association.

Journals

  • Shusterman, E., Beharier, O., Shiri, L., Zarivach, R., Etzion, Y., Campbell, C., Lee, I., Okabayashi, K., Dinudom, A., Cook, D., Moran, A., et al (2014). ZnT-1 extrudes zinc from mammalian cells functioning as a Zn(2+)/H(+) exchanger. Metallomics, 6(9), 1656-1663. [More Information]
  • Arnaiz, I., Johnson, M., Cook, D., Day, M. (2013). Changing expression of chloride channels during preimplantation mouse development. Reproduction, 145(1), 73-84. [More Information]
  • Campbell, C., Voyles, J., Cook, D., Dinudom, A. (2012). Frog skin epithelium: Electrolyte transport and chytridiomycosis. The International Journal of Biochemistry and Cell Biology, 44(3), 431-434. [More Information]
  • Lam, Y., Ha, C., Campbell, C., Mitchell, A., Dinudom, A., Oscarsson, J., Cook, D., Hunt, N., Caterson, I., Holmes, A., Storlien, L. (2012). Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-induced Obese Mice. PLoS One, 7(3), 1-10. [More Information]
  • Hee, L., Dinudom, A., Mitchell, A., Grau, G., Cook, D., Hunt, N., Ball, H. (2011). Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. International Journal for Parasitology, 41(1), 81-88. [More Information]
  • Lee, I., Song, S., Campbell, C., Kumar, S., Cook, D., Dinudom, A. (2011). Regulation of the Epithelial Na+ Channel by the RH-Domain of G Protein-coupled Receptor Kinase, GRK2, and Gαq/11. Journal of Biological Chemistry, 286(22), 19259-19269. [More Information]
  • Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D., et al (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9. [More Information]
  • Ousingsawat, J., Mirza, M., Tian, Y., Roussa, E., Schreiber, R., Cook, D., Kunzelmann, K. (2011). Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pfluegers Archiv: European journal of physiology, 461(5), 579-589. [More Information]
  • Hu, H., O'Mullane, L., Cummins, M., Campbell, C., Hosoda, Y., Poronnik, P., Dinudom, A., Cook, D. (2010). Negative regulation of Ca2+ influx during P2Y2 purinergic receptor activation is mediated by Gβγ-subunits. Cell Calcium, 47(1), 55-64. [More Information]
  • Voyles, J., Young, S., Berger, L., Campbell, C., Voyles, W., Dinudom, A., Cook, D., Webb, R., Alford, R., Skerratt, L., et al (2009). Pathogenesis of chytridiomycosis, a cause of catastrophic amphibian declines. Science, 326(5952), 582-585. [More Information]
  • O'Mullane, L., Cook, D., Dinudom, A. (2009). Purinergic regulation of the epithelial Na+ channel. Clinical and Experimental Pharmacology and Physiology, 36(10), 1016-1022. [More Information]
  • Lee, I., Campbell, C., Song, S., Day, M., Kumar, S., Cook, D., Dinudom, A. (2009). The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. Journal of Biological Chemistry, 284(19), 12663-12669. [More Information]
  • Lee, I., Campbell, C., Cook, D., Dinudom, A. (2008). Regulation of epithelial Na+ channels by aldosterone: role of Sgk1. Clinical and Experimental Pharmacology and Physiology, 35(2), 235-241. [More Information]
  • Wielpuetz, M., Lee, I., Dinudom, A., Boulkroun, S., Farman, N., Cook, D., Korbmacher, C., Rauh, R. (2007). (NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells. Journal of Biological Chemistry, 282(38), 28264-28273.
  • Lee, I., Dinudom, A., Sanchez-Perez, A., Kumar, S., Cook, D. (2007). Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Journal of Biological Chemistry, 282(41), 29866-29873. [More Information]
  • Sanchez-Perez, A., Kumar, S., Cook, D. (2007). GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2. Biochemical and Biophysical Research Communications, 359(3), 611-615. [More Information]
  • Kunzelmann, K., Sun, J., Meanger, J., King, N., Cook, D. (2007). Inhibition of airway Na+ transport by respiratory syncytial virus. Journal of Virology, 81(8), 3714-3720. [More Information]
  • Arthur, J., Sanchez-Perez, A., Cook, D. (2006). Scoring of predicted GRK2 phosphorylation sites in Nedd4-2. Bioinformatics. [More Information]
  • Rauh, R., Dinudom, A., Fotia, A., Paulides, M., Kumar, S., Korbmacher, C., Cook, D. (2006). Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pfluegers Archiv: European journal of physiology, 452(3), 290-299. [More Information]
  • Fotia, A., Cook, D., Kumar, S. (2006). The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities. The International Journal of Biochemistry and Cell Biology, 38(3), 472-479. [More Information]
  • Kunzelmann, K., Konig, J., Sun, J., Markovich, D., King, N., Karupiah, G., Young, J., Cook, D. (2004). Acute Effects Of Parainfluenza Virus On Epithelial Electrolyte Transport. Journal of Biological Chemistry, 279(47), 48760-48766.
  • Keech, A., Wonders, S., Cook, D., Gebski, V. (2004). Balancing the outcomes: reporting adverse events. Medical Journal of Australia, 181(4), 215-218.
  • Winston, N., Johnson, M., McConnell, J., Cook, D., Day, M. (2004). Expression And Role Of The Ether-à-Go-Go-Related (MERG1A) Potassium-Channel Protein During Preimplantation Mouse Development. Biology Of Reproduction, 70(4), 1070-1079.
  • Hryciw, D., Ekberg, J., Lee, A., Lensink, I., Kumar, S., Guggino, W., Cook, D., Pollock, C., Poronnik, P. (2004). Nedd4-2 Functionally Interacts With Clc-5: Involvement In Constitutive Albumin Endocytosis In Proximal Tubule Cells. Journal of Biological Chemistry, 279(53), 54996-55007.
  • Fotia, A., Ekberg, J., Adams, D., Cook, D., Poronnik, P., Kumar, S. (2004). Regulation Of Neuronal Voltage-Gated Sodium Channels By The Ubiquitin-Protein Ligases Nedd4 And Nedd4-2. Journal of Biological Chemistry, 279(28), 28930-28935.
  • Cook, D., Gebski, V., Keech, A. (2004). Subgroup analysis in clinical trials. Medical Journal of Australia, 180(6), 289-291.
  • Dinudom, A., Fotia, A., Lefkowitz, R., Young, J., Kumar, S., Cook, D. (2004). The Kinase Grk2 Regulates Nedd4/Nedd4-2-Dependent Control Of Epithelial Na+ Channels. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 101(32), 11886-11890.
  • Weinhaus, A., TABIIN, M., Poronnik, P., PALMA, C., Cook, D., Tuch, B. (2003). Insulin secretagogues, but not glucose, stimulate an increase in (Ca2+)i in the fetal human and porcine Beta-cell. Journal of Clinical Endocrinology and Metabolism, 88(6), 2753-2759.
  • Fotia, A., Dinudom, A., Shearwin, K., Koch, J., Korbmacher, C., Cook, D., Kumar, S. (2003). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. The F A S E B Journal, 17(1), 70-72.
  • Cummins, M., O'Mullane, L., Barden, J., Cook, D., Poronnik, P. (2002). Antisense co-suppression of Galphaq & Galpha11 demonstrates that both isoforms mediate M3-receptor-activated Ca2+ signalling in intact epithelial cells. Pfluegers Archiv: European journal of physiology, 444(5), 644-653. [More Information]
  • Harding, E., Gibb, C., Johnson, M., Cook, D., Day, M. (2002). Developmental changes in the management of acid loads during preimplantation mouse development. Biology Of Reproduction, 67(5), 1419-1429.
  • Kunzelmann, K., Schreiber, R., Cook, D. (2002). Mechanisms for the inhibition of amilorie-sensitive Na+ absorption by extracellular nucleotides in mouse trachea. European Journal of Applied Physiology, 444(1-2), 220-226. [More Information]
  • Konstas, A., Shearwin-Whyatt, L., Fotia, A., Degger, B., Riccardi, D., Cook, D., Korbmacher, C., Kumar, S. (2002). Regulation of the epithelial sodium channel by N4WBP5A a novel Nedd4/Nedd4-2-interacting protein. Journal of Biological Chemistry, 277(33), 29406-29416.
  • Fotia, A., Dinudom, A., Shearwin, K., Koch, J., Korbacher, C., Cook, D., Kumar, S. (2002). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. The F A S E B Journal, 10(1), 1-22.
  • Cook, D., Young, J. (2002). Towards a physiology of epithelial pathogens. European Journal of Applied Physiology, 443(3), 339-343.
  • Dinudom, A., Komwatana, P., Young, J., Cook, D., Harvey, K., Jolliffe, C., Kumar, S. (2001). Roles of the C Termini of alpha, beta and subunits of epithelial Na+ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na+. Journal of Biological Chemistry, 276, 13744-13749.
  • Dinudom, A., Cook, D., Harvey, K., Kumar, S. (2001). The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. Journal of Biological Chemistry, 276, 8597-8601.
  • Day, M., Winston, N., Cook, D., Johnson, M., McConnel, J. (2001). tiK+ toK+: an embryonic clock? Reproduction, Fertility and Development, 13, 69-79.

Conferences

  • Monkaresi, H., Calvo, R., Chow, K., Mullan, B., Lam, M., Twigg, S., Cook, D. (2013). Intelligent Diabetes Lifestyle Coach. 25th Australian Computer-Human Interaction Conference: Augmentation, Application, Innovation, Collaboration (OzCHI 2013), Adelaide, Australia: Association for Computing Machinery (ACM).
  • Hryciw, D., Ekberg, J., Lee, A., Lensink, I., Kumar, S., Guggino, W., Cook, D., Pollock, C., Poronnik, P. (2012). Nedd4-2 is required for constitutive albumin endocytosis in proximal tubule cells. 35th International Congress of Physiological Sciences, United States: Federation of American Societies for Experimental Biology.
  • Day, M., Bailey, C., Rasko, J., Johnson, M., Cook, D. (2005). Maintenance of potassium channel activity prevents cell division in the mouse preimplantation embryo. The Society for the Study of Reproduction 38th Annual Meeting (SSR 2005), Kansas, USA: Allen Press Inc.
  • Hu, H., Cook, D. (2005). Phospholipase C beta isoforms mediating the CCh-induced calcium response. 35th International Congress of Physiological Sciences, United States: Federation of American Societies for Experimental Biology.
  • Ekberg, J., Fotia, A., Adams, D., Cook, D., Kumar, S., Poronnik, P. (2005). Sglk-1 and Nedd4/4-2 regulation of voltage-sensitive sodium channels. 35th International Congress of Physiological Sciences, United States: Federation of American Societies for Experimental Biology.

2014

  • Shusterman, E., Beharier, O., Shiri, L., Zarivach, R., Etzion, Y., Campbell, C., Lee, I., Okabayashi, K., Dinudom, A., Cook, D., Moran, A., et al (2014). ZnT-1 extrudes zinc from mammalian cells functioning as a Zn(2+)/H(+) exchanger. Metallomics, 6(9), 1656-1663. [More Information]

2013

  • Arnaiz, I., Johnson, M., Cook, D., Day, M. (2013). Changing expression of chloride channels during preimplantation mouse development. Reproduction, 145(1), 73-84. [More Information]
  • Monkaresi, H., Calvo, R., Chow, K., Mullan, B., Lam, M., Twigg, S., Cook, D. (2013). Intelligent Diabetes Lifestyle Coach. 25th Australian Computer-Human Interaction Conference: Augmentation, Application, Innovation, Collaboration (OzCHI 2013), Adelaide, Australia: Association for Computing Machinery (ACM).

2012

  • Campbell, C., Voyles, J., Cook, D., Dinudom, A. (2012). Frog skin epithelium: Electrolyte transport and chytridiomycosis. The International Journal of Biochemistry and Cell Biology, 44(3), 431-434. [More Information]
  • Lam, Y., Ha, C., Campbell, C., Mitchell, A., Dinudom, A., Oscarsson, J., Cook, D., Hunt, N., Caterson, I., Holmes, A., Storlien, L. (2012). Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-induced Obese Mice. PLoS One, 7(3), 1-10. [More Information]
  • Hryciw, D., Ekberg, J., Lee, A., Lensink, I., Kumar, S., Guggino, W., Cook, D., Pollock, C., Poronnik, P. (2012). Nedd4-2 is required for constitutive albumin endocytosis in proximal tubule cells. 35th International Congress of Physiological Sciences, United States: Federation of American Societies for Experimental Biology.

2011

  • Hee, L., Dinudom, A., Mitchell, A., Grau, G., Cook, D., Hunt, N., Ball, H. (2011). Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. International Journal for Parasitology, 41(1), 81-88. [More Information]
  • Lee, I., Song, S., Campbell, C., Kumar, S., Cook, D., Dinudom, A. (2011). Regulation of the Epithelial Na+ Channel by the RH-Domain of G Protein-coupled Receptor Kinase, GRK2, and Gαq/11. Journal of Biological Chemistry, 286(22), 19259-19269. [More Information]
  • Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D., et al (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9. [More Information]
  • Ousingsawat, J., Mirza, M., Tian, Y., Roussa, E., Schreiber, R., Cook, D., Kunzelmann, K. (2011). Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pfluegers Archiv: European journal of physiology, 461(5), 579-589. [More Information]

2010

  • Hu, H., O'Mullane, L., Cummins, M., Campbell, C., Hosoda, Y., Poronnik, P., Dinudom, A., Cook, D. (2010). Negative regulation of Ca2+ influx during P2Y2 purinergic receptor activation is mediated by Gβγ-subunits. Cell Calcium, 47(1), 55-64. [More Information]

2009

  • Voyles, J., Young, S., Berger, L., Campbell, C., Voyles, W., Dinudom, A., Cook, D., Webb, R., Alford, R., Skerratt, L., et al (2009). Pathogenesis of chytridiomycosis, a cause of catastrophic amphibian declines. Science, 326(5952), 582-585. [More Information]
  • O'Mullane, L., Cook, D., Dinudom, A. (2009). Purinergic regulation of the epithelial Na+ channel. Clinical and Experimental Pharmacology and Physiology, 36(10), 1016-1022. [More Information]
  • Lee, I., Campbell, C., Song, S., Day, M., Kumar, S., Cook, D., Dinudom, A. (2009). The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. Journal of Biological Chemistry, 284(19), 12663-12669. [More Information]

2008

  • Cook, D., Keech, A., Gebski, V., Pike, R., Wonders, S. (2008). Balancing the outcomes: reporting harms (adverse events). In Anthony Keech, Val Gebski, Rhana Pike (Eds.), Interpreting and reporting clinical trials: a guide to the CONSORT statement and the principles of randomised controlled trials, (pp. 132-142). Sydney: AMPCo.
  • Lee, I., Campbell, C., Cook, D., Dinudom, A. (2008). Regulation of epithelial Na+ channels by aldosterone: role of Sgk1. Clinical and Experimental Pharmacology and Physiology, 35(2), 235-241. [More Information]

2007

  • Wielpuetz, M., Lee, I., Dinudom, A., Boulkroun, S., Farman, N., Cook, D., Korbmacher, C., Rauh, R. (2007). (NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells. Journal of Biological Chemistry, 282(38), 28264-28273.
  • Lee, I., Dinudom, A., Sanchez-Perez, A., Kumar, S., Cook, D. (2007). Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Journal of Biological Chemistry, 282(41), 29866-29873. [More Information]
  • Sanchez-Perez, A., Kumar, S., Cook, D. (2007). GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2. Biochemical and Biophysical Research Communications, 359(3), 611-615. [More Information]
  • Kunzelmann, K., Sun, J., Meanger, J., King, N., Cook, D. (2007). Inhibition of airway Na+ transport by respiratory syncytial virus. Journal of Virology, 81(8), 3714-3720. [More Information]
  • Cook, D., Keech, A., Gebski, V. (2007). Subgroup analysis in clinical trials. In Anthony Keech, Val Gebski, Rhana Pike (Eds.), Interpreting and reporting clinical trials: a guide to the CONSORT statement and the principles of randomised controlled trials, (pp. 105-113). Sydney: AMPCo.

2006

  • Arthur, J., Sanchez-Perez, A., Cook, D. (2006). Scoring of predicted GRK2 phosphorylation sites in Nedd4-2. Bioinformatics. [More Information]
  • Rauh, R., Dinudom, A., Fotia, A., Paulides, M., Kumar, S., Korbmacher, C., Cook, D. (2006). Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pfluegers Archiv: European journal of physiology, 452(3), 290-299. [More Information]
  • Fotia, A., Cook, D., Kumar, S. (2006). The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities. The International Journal of Biochemistry and Cell Biology, 38(3), 472-479. [More Information]

2005

  • Day, M., Bailey, C., Rasko, J., Johnson, M., Cook, D. (2005). Maintenance of potassium channel activity prevents cell division in the mouse preimplantation embryo. The Society for the Study of Reproduction 38th Annual Meeting (SSR 2005), Kansas, USA: Allen Press Inc.
  • Hu, H., Cook, D. (2005). Phospholipase C beta isoforms mediating the CCh-induced calcium response. 35th International Congress of Physiological Sciences, United States: Federation of American Societies for Experimental Biology.
  • Ekberg, J., Fotia, A., Adams, D., Cook, D., Kumar, S., Poronnik, P. (2005). Sglk-1 and Nedd4/4-2 regulation of voltage-sensitive sodium channels. 35th International Congress of Physiological Sciences, United States: Federation of American Societies for Experimental Biology.

2004

  • Kunzelmann, K., Konig, J., Sun, J., Markovich, D., King, N., Karupiah, G., Young, J., Cook, D. (2004). Acute Effects Of Parainfluenza Virus On Epithelial Electrolyte Transport. Journal of Biological Chemistry, 279(47), 48760-48766.
  • Keech, A., Wonders, S., Cook, D., Gebski, V. (2004). Balancing the outcomes: reporting adverse events. Medical Journal of Australia, 181(4), 215-218.
  • Winston, N., Johnson, M., McConnell, J., Cook, D., Day, M. (2004). Expression And Role Of The Ether-à-Go-Go-Related (MERG1A) Potassium-Channel Protein During Preimplantation Mouse Development. Biology Of Reproduction, 70(4), 1070-1079.
  • Hryciw, D., Ekberg, J., Lee, A., Lensink, I., Kumar, S., Guggino, W., Cook, D., Pollock, C., Poronnik, P. (2004). Nedd4-2 Functionally Interacts With Clc-5: Involvement In Constitutive Albumin Endocytosis In Proximal Tubule Cells. Journal of Biological Chemistry, 279(53), 54996-55007.
  • Fotia, A., Ekberg, J., Adams, D., Cook, D., Poronnik, P., Kumar, S. (2004). Regulation Of Neuronal Voltage-Gated Sodium Channels By The Ubiquitin-Protein Ligases Nedd4 And Nedd4-2. Journal of Biological Chemistry, 279(28), 28930-28935.
  • Cook, D., Gebski, V., Keech, A. (2004). Subgroup analysis in clinical trials. Medical Journal of Australia, 180(6), 289-291.
  • Dinudom, A., Fotia, A., Lefkowitz, R., Young, J., Kumar, S., Cook, D. (2004). The Kinase Grk2 Regulates Nedd4/Nedd4-2-Dependent Control Of Epithelial Na+ Channels. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 101(32), 11886-11890.

2003

  • Weinhaus, A., TABIIN, M., Poronnik, P., PALMA, C., Cook, D., Tuch, B. (2003). Insulin secretagogues, but not glucose, stimulate an increase in (Ca2+)i in the fetal human and porcine Beta-cell. Journal of Clinical Endocrinology and Metabolism, 88(6), 2753-2759.
  • Fotia, A., Dinudom, A., Shearwin, K., Koch, J., Korbmacher, C., Cook, D., Kumar, S. (2003). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. The F A S E B Journal, 17(1), 70-72.

2002

  • Cummins, M., O'Mullane, L., Barden, J., Cook, D., Poronnik, P. (2002). Antisense co-suppression of Galphaq & Galpha11 demonstrates that both isoforms mediate M3-receptor-activated Ca2+ signalling in intact epithelial cells. Pfluegers Archiv: European journal of physiology, 444(5), 644-653. [More Information]
  • Harding, E., Gibb, C., Johnson, M., Cook, D., Day, M. (2002). Developmental changes in the management of acid loads during preimplantation mouse development. Biology Of Reproduction, 67(5), 1419-1429.
  • Kunzelmann, K., Schreiber, R., Cook, D. (2002). Mechanisms for the inhibition of amilorie-sensitive Na+ absorption by extracellular nucleotides in mouse trachea. European Journal of Applied Physiology, 444(1-2), 220-226. [More Information]
  • Konstas, A., Shearwin-Whyatt, L., Fotia, A., Degger, B., Riccardi, D., Cook, D., Korbmacher, C., Kumar, S. (2002). Regulation of the epithelial sodium channel by N4WBP5A a novel Nedd4/Nedd4-2-interacting protein. Journal of Biological Chemistry, 277(33), 29406-29416.
  • Fotia, A., Dinudom, A., Shearwin, K., Koch, J., Korbacher, C., Cook, D., Kumar, S. (2002). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. The F A S E B Journal, 10(1), 1-22.
  • Jaeschke, R., Guyatt,, G., Barratt, A., Walters, S., Cook, D., McAlister, F., Attia, J. (2002). Therapy and Understanding the Results: Measures of Association. In Gordon Guyatt & Drummond Rennie (Eds.), Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, (pp. 363-389). United States: American Medical Association.
  • Cook, D., Young, J. (2002). Towards a physiology of epithelial pathogens. European Journal of Applied Physiology, 443(3), 339-343.

2001

  • Dinudom, A., Komwatana, P., Young, J., Cook, D., Harvey, K., Jolliffe, C., Kumar, S. (2001). Roles of the C Termini of alpha, beta and subunits of epithelial Na+ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na+. Journal of Biological Chemistry, 276, 13744-13749.
  • Dinudom, A., Cook, D., Harvey, K., Kumar, S. (2001). The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. Journal of Biological Chemistry, 276, 8597-8601.
  • Day, M., Winston, N., Cook, D., Johnson, M., McConnel, J. (2001). tiK+ toK+: an embryonic clock? Reproduction, Fertility and Development, 13, 69-79.

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