Professor David Le Couteur

Professor
Medicine, Concord Clinical School
ANZAC Research Institute

Telephone +61 2 9767 6935
Fax +61 2 9767 5419

Map

Research interests

Biogerontology, Liver and aging, Liver sinusoid and aging, geriatric pharmacology

Selected grants

2015

  • Ageing and latelife health: calories, macronutrients or branched chain amino acids; Simpson S, Le Couteur D, Sinclair D, De Cabo R; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Health and lifespan regulation by NAD+ and SIRT2; Turner N, Sinclair D, Le Couteur D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Fenestrations and insulin; Le Couteur D; DVC Research/Bridging Support Grant.
  • Centre of Research Excellence in Medicines and Ageing; McLachlan A, Pearson S, Banks E, Preen D, Le Couteur D, Dobbins T, Etherton-Beer C, Buckley N, Viney R, Henry D; National Health and Medical Research Council (NHMRC)/Centres of Research Excellence.
  • EVOS FL Auto cell imaging system; Nicholson G, Clark G, Zhou H, Jessup W, Le Couteur D, McMahon A, McLachlan A, Allan C, Handelsman D, Hart D, Walters K, Kritharides L, Kockx M, Kennerson M, Cooper M, Seibel M, Verma N, Silveira P, Fromm P, Simanainen U, Cogger V, Zheng Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Automacs Pro Seperator; Hart D, Handelsman D, Le Couteur D, Nicholson G, Kritharides L, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, Simanainen U, Zheng Y, Seibel M; DVC Research/Equipment Grant.
  • Insights from ageing and calorie restriction for the prevention and treatment of paracetamol hepatotoxicity; Hilmer S, Kane A, Le Couteur D, Cogger V; Australian Association of Gerontology/RM Gibson Research Grants.
  • Patterns of care and health outcomes: Opportunities for epidemiology and health services research using whole of population, cross-jurisdictional linkage of routinely collected data; Aranda S, Currow D, Pearson S, Young J, Armstrong B, O'Connell D, McLachlan A, Le Couteur D, Buckley N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • IVIS Lumina II in vivo Imaging System; Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Speranza T, Zheng Y; DVC Research/Equipment Grant.

2012

  • High risk prescribing in older Australians; Le Couteur D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • High risk prescribing in older Australians; Banks E, Le Couteur D, Pearson S, McLachlan A, Viney R, Hilmer S, Gnjidic D, Blyth F; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • MOLECULAR IMAGER CHEMIDoc XRS SYSTEM & MINI P ROTEAN GEL/TRANSBLOT Cell SYSTEM (BIO-RAD. AUSTRALIA; Allan C, Handelsman D, Zhou H, Seibel M, Kennerson M, Nicholson G, Blair I, Le Couteur D, McMahon A, Hart D, Clark G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Ageing, Nutrition and Geometric Framework; Cumming R, Simpson S, Le Couteur D, Blyth F, Naganathan V, Kendig H, Seibel M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Lunar PIXImus II DEXA Scanner; Zhou H, Seibel M, Handelsman D, Le Couteur D, Nicholson G, Clarke S, Robertson G, van Zandwijk N, Freedman B, Kennerson M, Allan C, Walters K, Cogger V, Blair I, Reid G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • The Nutritional geometry of ageing in a rodent model ; Simpson S, Le Couteur D, Raubenheimer D, Ballard J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Optimising pain management in frail older people; McLachlan A, Naganathan V, Le Couteur D, Hilmer S, Gibson S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ageing, Werner syndrome and Pseudocapillarization; Le Couteur D, Cogger V, Lebel M, Quinn R, Hilmer S, McCuskey R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Stereomicroscope-Imaging Workstation; Allan C, Seibel M, Handelsman D, Le Couteur D, Kennerson M, Robertson G, Walters K, Cogger V, Nicholson G, Zhou H, Blair I, Simanainen U, McMahon A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Sirtuins and the molecular epidemiology of frailty in older men; De Cabo R, Cumming R, Le Couteur D, Kennerson M, De Cabo R, Naganathan V, Sambrook P; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Caloric restriction, ageing and the liver sinusoidal endothelium: mechanisms and implications; Le Couteur D, De Cabo R, De Cabo R, Cogger V, Hilmer S, Frazer R; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Cell culture quarantine and storage facility plus assessories; Dunstan C, Witting P, Myers S, Handelsman D, Seibel M, Nicholson G, Zhou H, Kennerson M, Allan C, Freedman B, Le Couteur D, Muller M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • KODAK Image Station 2000mm Multi-Modal Imager; Seibel M, Nicholson G, Witting P, Le Couteur D, Freedman B, Dunstan C, Blair J, Kennerson M, Myers S, Muller M; University of Sydney/Major Equipment.

2005

  • Bio-Rad iCycler iQ5 Real-Time PCR & Mutation detection system; Seibel M, Le Couteur D, Freedman B, Nicholson G, Handelsman D, Kennerson M, Dunstan C, Allan C, Witting P, Kril J, Muller M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Mechanisms for ageing changes in the hepatic sinusoid; Le Couteur D, McKinnon K, Fraser R, Muller M, Cogger V, Harris M, Sullivan D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • How is lipoprotein disposition influenced by fenestrae in the hepatic sinusoidal endothelium?; Le Couteur D, McKinnon K, Fraser R, Cogger V, Sullivan D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Victor 3 Multi-label Plate Reader; Witting P, Handelsman D, Le Couteur D, Nicholson G, Seibel M, Kril J, Kritharides L, Kennerson M; University of Sydney/Major Equipment.

2004

  • Dual Energy X-Ray (DEXA) densitometer hologic discovery W and software; Cumming R, Handelsman D, Seibel M, Sambrook P, Naganathan V, Mitchell P, Le Couteur D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Digital stereo Investigator system; Handelsman D, Allan C, Le Couteur D, Nicholson G, Illingworth P, Kril J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • OPTIMAX TLX 120 ultracentrifuge; Witting P, Handelsman D, Nicholson G, Lay P, Kritharides L, Kril J, Le Couteur D, Lowe H, Kennerson M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The aetiology of Parkinsons disease; Le Couteur D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Concord hormones and ageing in men project; Naganathan V, Le Couteur D, Cumming R, Handelsman D, Seibel M, Creasey H, Sambrook P, Waite L; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Australian Ageing Alliance. Application two: Geriatric pharmacology; Le Couteur D, Cumming R; National Health and Medical Research Council (NHMRC)/Strategic Research Development Committee (SDRC): Healthy Ageing.
  • The effect of hepatic pseudocapillarisation of old age on the disposition of chylomicron remnants and chylomicrons; Le Couteur D, Sullivan D, Fraser R, McLean A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Axio vert 25CFL inverted microscope; Biolab safety cabinet; Biolab EMA incubator; Biolab EMA autoclave; Le Couteur D, Harris M, Kril J, Allan C, Handelsman D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Pharmacological, metabolic & therapeutic implications of the oxygen diffusion barrier hypothesis of ageing in the liver; Le Couteur D; Department of Veterans' Affairs/Research Grant.
  • Mass spectrometry upgrade to HPLC; Kril J, Lim J, Illingworth P, Seibel M, Nicholson G, Le Couteur D, Handelsman D; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2001

  • Scoping study on ageing research; Le Couteur D, Khalil Z, Kendig H, McCallum J, Andrews D; National Health and Medical Research Council (NHMRC)/Strategic Research Development Committee (SDRC): Healthy Ageing.
  • Not known; Le Couteur D; DVC Research/Research and Development Scheme: Research and Development (R&D).

2000

  • Waters high performance liquid chromatography (HPLC) system; Le Couteur D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Hepatic oxygenation and aging; Le Couteur D, McLean A, Ansselin A; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers.
  • McMahon, A., Hing, A., Cogger, V., Le Couteur, D. (2011). Animal models of early atherosclerosis: How to translate the data into clinical perspectives. In Petru Liuba (Eds.), Silent Vasculopathy in Childhood: Should Clinicians Care, (pp. 39-64). India: Transworld Research Network.
  • Everitt, A., Heilbronn, L., Morris, B., Brown-Borg, H., Merry, B., Simpson, S., Varady, K., Masoro, E., Redman, L., Le Couteur, D. (2010). Conclusion: Human Calorie Restriction and Anti-Aging Therapy. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 311-318). Dordrecht: Springer.
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2010). Dosing Errors: Age-Related Changes in Pharmacokinetics. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 127-135). New York: Springer Science + Business Media.
  • Everitt, A., Heilbronn, L., Le Couteur, D. (2010). Food Intake, Life Style, Aging and Human Longevity. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 15-41). Dordrecht: Springer.
  • Everitt, A., Brown-Borg, H., Le Couteur, D., Bartke, A. (2010). Food Restriction, Hormones, Genes and Aging. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 217-318). Dordrecht: Springer.
  • Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer.
  • Le Couteur, D., Kendig, H., Naganathan, V., McLachlan, A. (2010). The Ethics of Prescribing Medications to Older People. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 29-42). New York: Springer Science + Business Media.
  • Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.
  • Le Couteur, D., Naganathan, V., Cogger, V., Cumming, R., McLean, A. (2006). Pharmacotherapy in the elderly: clinical issues and perspectives. In Kohli K, Gupta M, Tejwani S. (Eds.), In Contemporary Perspectives on Clinical Pharmacotherapeutics, (pp. 709-722). New Dehli: Elsevier.

Journals

  • Fransen, M., Su, S., Harmer, A., Blyth, F., Naganathan, V., Sambrook, P., Le Couteur, D., Cumming, R. (2014). A longitudinal study of knee pain in older men: Concord Health and Ageing in Men Project. Age and Ageing, 43(2), 206-212. [More Information]
  • Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
  • Le Couteur, D., Simpson, S., De Cabo, R. (2014). Are glycans the holy grail for biomarkers of aging? (Comment on: Glycans Are a Novel Biomarker of Chronological and Biological Age by Kristic et al.). Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(7), 777-778. [More Information]
  • Hirani, V., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014). Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(3), 417-425. [More Information]
  • Cogger, V., Svistounov, D., Warren, A., Zykova, S., Melvin, R., Solon-Biet, S., O'Reilly, J., McMahon, A., Ballard, J., De Cabo, R., Le Couteur, D., et al (2014). Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(9), 1076-1086. [More Information]
  • Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Longitudinal and Cross-Sectional Relationships of Circulating Reproductive Hormone Levels to Self-Rated Health and Health-Related Quality of Life in Community-Dwelling Older Men. Journal of Clinical Endocrinology and Metabolism, 99(5), 1638-1647. [More Information]
  • Hsu, B., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Longitudinal relationships of circulating reproductive hormone with functional disability, muscle mass and strength in community-dwelling older men; The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 99(9), 3310-3318. [More Information]
  • Hirani, V., Cumming, R., Le Couteur, D., Naganathan, V., Blyth, F., Handelsman, D., Waite, L., Seibel, M. (2014). Low Levels of 25-Hydroxy Vitamin D and Active 1,25-Dihydroxyvitamin D Independently Associated with Type 2 Diabetes Mellitus in Older Australian Men: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(9), 1741-1747. [More Information]
  • Gnjidic, D., Blyth, F., Le Couteur, D., Cumming, R., McLachlan, A., Handelsman, D., Seibel, M., Waite, L., Naganathan, V. (2014). Nonsteroidal anti-inflammatory drugs (NSAIDs) in older people: Prescribing patterns according to pain prevalence and adherence to clinical guidelines. Pain, 155(9), 1814-1820. [More Information]
  • Fairhall, N., Sherrington, C., Cameron, I., Blyth, F., Naganathan, V., Clemson, L., Le Couteur, D., Handelsman, D., Waite, L., Cumming, R. (2014). Predicting participation restriction in community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 43(1), 31-37. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Bell, J. (2014). Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology, 28(1), 10-19. [More Information]
  • Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
  • Le Couteur, D., Wilder, S., De Cabo, R., Simpson, S. (2014). The Evolution of Research on Ageing and Nutrition. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(1), 1-2. [More Information]
  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]
  • Bleicher, K., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014). U-Shaped Association Between Serum 25-Hydroxyvitamin D and Fracture Risk in Older Men: Results from the Prospective Population Based CHAMP Study. Journal of Bone and Mineral Research, 29(9), 2024-2031. [More Information]
  • Cogger, V., Roessner, U., Warren, A., Fraser, R., Le Couteur, D. (2013). A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations. Computational and Structural Biotechnology Journal, 8(11), 1-9. [More Information]
  • Hirani, V., Naganathan, V., Cumming, R., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013). Associations Between Frailty and Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Concentrations in Older Australian Men: The Concord Health and Ageing in Men Project. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 68(9), 1112-1121. [More Information]
  • McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013). Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica, 50(4), 645-649. [More Information]
  • Wilder, S., Le Couteur, D., Simpson, S. (2013). Diet mediates the relationship between longevity and reproduction in mammals. Age, 35(3), 921-927. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2013). Discontinuation of statins in routine care settings. Annals of Internal Medicine, 159(1), 73-74. [More Information]
  • Huang, X., Hancock, D., Gosby, A., McMahon, A., Solon-Biet, S., Le Couteur, D., Conigrave, A., Raubenheimer, D., Simpson, S. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage and heat production in mice. Obesity, 21(1), 85-92. [More Information]
  • Gnjidic, D., Le Couteur, D., Pearson, S., McLachlan, A., Viney, R., Hilmer, S., Blyth, F., Joshy, G., Banks, E. (2013). High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health, 13, 1-9. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2013). Optimal cutoff of polypharmacy and outcomes - reply. Journal of Clinical Epidemiology, 66(4), 465-466. [More Information]
  • Le Couteur, D., Doust, J., Creasey, H., Brayne, C. (2013). Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis. BMJ (International Edition), 347(7925), 1-6. [More Information]
  • Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2013). Predictors of the rate of BMD loss in older men: findings from the CHAMP study. Osteoporosis International, 24(7), 1951-1963. [More Information]
  • Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., et al (2013). Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review, 32(2), 218-222. [More Information]
  • Horan, M., Rumbley, J., Melvin, R., Le Couteur, D., Ballard, J. (2013). Quaternary protein modeling to predict the function of DNA variation found in human mitochondrial cytochrome c oxidase. Journal of Human Genetics, 58(3), 127-134. [More Information]
  • Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013). Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open, 3(3), 1-10. [More Information]
  • Hirani, V., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013). Vitamin D Status Among Older Community Dwelling Men Living In A Sunny Country And Associations With Lifestyle Factors: The Concord Health And Ageing In Men Project, Sydney, Australia. The Journal of Nutrition, Health and Aging, 17(7), 587-593. [More Information]
  • Le Couteur, D., Robinson, M., Leverton, A., Creasey, H., Waite, L., Atkins, K., McLachlan, A. (2012). Adherence, persistence and continuation with cholinesterase inhibitors in Alzheimer's disease. Australasian Journal on Ageing, 31(3), 164-169. [More Information]
  • Le Couteur, D., McLachlan, A., Quinn, R., Simpson, S., De Cabo, R. (2012). Aging biology and novel targets for drug discovery. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 168-174. [More Information]
  • Le Couteur, D., McLachlan, A., De Cabo, R. (2012). Aging, Drugs, and Drug Metabolism. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 137-139. [More Information]
  • Baur, J., Ungvari, Z., Minor, R., Le Couteur, D., De Cabo, R. (2012). Are sirtuins viable targets for improving healthspan and lifespan? Nature Reviews. Drug Discovery, 11(6), 443-461. [More Information]
  • Gnjidic, D., Le Couteur, D., Kouladjian, L., Hilmer, S. (2012). Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clinics in Geriatric Medicine, 28(2), 237-253. [More Information]
  • Le Couteur, D., Handelsman, D. (2012). DNA damage, NF-κB and accelerated aging. Asian Journal of Andrology, 14(6), 811-812. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2012). Drug Burden Index and Beers Criteria: Impact on Functional Outcomes in Older People Living in Self-Care Retirement Villages. The Journal of Clinical Pharmacology, 52(2), 258-265. [More Information]
  • Gnjidic, D., Le Couteur, D., Naganathan, V., Cumming, R., Creasey, H., Waite, L., Sharma, A., Blyth, F., Hilmer, S. (2012). Effects of drug burden index on cognitive function in older men. Journal of Clinical Psychopharmacology, 32(2), 273-277. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology and Therapeutics, 91(3), 521-528. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2012). High-risk prescribing in older people: More harm than good? Aging Health, 8(4), 325-327. [More Information]
  • Bell, S., Le Couteur, D., McLachlan, A., Chen, T., Moles, R., Basger, B., Hilmer, S. (2012). Improving medicine selection for older people: Do we need an Australian classification for inappropriate medicines use? Australian Family Physician, 41(1/2), 9-10. [More Information]
  • Gnjidic, D., Stanaway, F., Cumming, R., Waite, L., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D. (2012). Mild Cognitive Impairment Predicts Institutionalization among Older Men: A Population-Based Cohort Study. PLoS One, 7(9), 1-8. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2012). Off-Label Use of Medicines: Time for Action. Clinical Pharmacology and Therapeutics, 92(2), 157-157. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012). Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989-995. [More Information]
  • Litchfield, M., Cumming, R., Smith, D., Naganathan, V., Le Couteur, D., Waite, L., Blyth, F., Handelsman, D. (2012). Prostate-specific antigen levels in men aged 70 years and over: Findings from the CHAMP study. Medical Journal of Australia, 196(6), 395-398. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Svistounov, D., Warren, A., McNerney, G., Owen, D., Zencak, D., Zykova, S., Crane, H., Huser, T., Quinn, R., Smedsrod, B., Le Couteur, D., Cogger, V. (2012). The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells. PLoS One, 7(9), 1-9. [More Information]
  • Sorensen, K., McCourt, P., Berg, T., Crossley, C., Le Couteur, D., Wake, K., Smedsrod, B. (2012). The scavenger endothelial cell: a new player in homeostasis and immunity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 303(12), R1217-R1230. [More Information]
  • Hilmer, S., Gnjidic, D., Le Couteur, D. (2012). Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Australian Family Physician, 41(12), 924-928. [More Information]
  • Le Couteur, D., Simpson, S. (2011). Adaptive Senectitude: The Prolongevity Effects of Aging. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(2), 179-182. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • Stanaway, F., Blyth, F., Cumming, R., Naganathan, V., Handelsman, D., Waite, L., Sambrook, P., Creasey, H., Seibel, M., Le Couteur, D. (2011). Back pain in older male Italian-born immigrants in Australia: The importance of socioeconomic factors. European Journal of Pain, 15(1), 70-76. [More Information]
  • Travison, T., Nguyen, A., Naganathan, V., Stanaway, F., Blyth, F., Cumming, R., Le Couteur, D., Sambrook, P., Handelsman, D. (2011). Changes in Reproductive Hormone Concentrations Predict the Prevalence and Progression of the Frailty Syndrome in Older Men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 96(8), 2464-2474. [More Information]
  • McLachlan, A., Bath, S., Naganathan, V., Hilmer, S., Le Couteur, D., Gibson, S., Blyth, F. (2011). Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. British Journal of Clinical Pharmacology, 71(3), 351-364. [More Information]
  • Le Couteur, D., Banks, E., Gnjidic, D., McLachlan, A. (2011). Deprescribing. Australian Prescriber, 34(6), 182-185.
  • Le Couteur, D., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Kennerson, M., Naganathan, V., Cumming, R., De Cabo, R. (2011). Determinants of Serum-Induced SIRT1 Expression in Older Men: The CHAMP Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(1), 3-8. [More Information]
  • Stanaway, F., Cumming, R., Naganathan, V., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M., Sambrook, P. (2011). Ethnicity and falls in older men: low rate of falls in Italian-born men in Australia. Age and Ageing, 40, 595-601. [More Information]
  • Le Couteur, D., Cogger, V., Dobbs, B., Fraser, R. (2011). Fenestrations and lipoproteins. Cardiovascular pathology, 20(3), 191-193. [More Information]
  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(40), 16735-16740. [More Information]
  • Stanaway, F., Gnjidic, D., Blyth, F., Le Couteur, D., Naganathan, V., Waite, L., Seibel, M., Handelsman, D., Sambrook, P., Cumming, R. (2011). How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ: British Medical Journal, 343, d7679-1-d7679-4. [More Information]
  • Blyth, F., Cumming, R., Nicholas, M., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2011). Intrusive Pain and Worry about Health in Older Men: The CHAMP Study. Pain, 152(2), 447-452. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2011). Reducing drugs in older adults is more. Archives of Internal Medicine, 171(9), 868-869. [More Information]
  • Labbé, A., Garand, C., Cogger, V., Paquet, E., Desbiens, M., Le Couteur, D., Lebel, M. (2011). Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(312492), 264-278. [More Information]
  • Nabipour, I., Sambrook, P., Blyth, F., Janu, M., Waite, L., Naganathan, V., Handelsman, D., Le Couteur, D., Cumming, R., Seibel, M. (2011). Serum Uric Acid Is Associated With Bone Health in Older Men: A Cross-Sectional Population-Based Study. Journal of Bone and Mineral Research, 26(5), 955-964. [More Information]
  • Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2011). Socioeconomic status and bone health in community-dwelling older men: The CHAMP Study. Osteoporosis International, 22(5), 1343-1353. [More Information]
  • Everitt, A., Le Couteur, D., Kendig, H. (2011). The Changing Face of Ageing Research and Practice in Australia over the last 50 years. Australasian Journal on Ageing, 30(4), 173-174. [More Information]
  • Warren, A., Cogger, V., Fraser, R., DeLeve, L., McCuskey, R., Le Couteur, D. (2011). The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research, 2011 (Article ID 439835), 1-7. [More Information]
  • Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]
  • Bleicher, K., Cumming, R., Naganathan, V., Travison, T., Sambrook, P., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M. (2011). The role of fat and lean mass in bone loss in older men: Findings from the CHAMP study. Bone, 49(6), 1299-1305. [More Information]
  • Le Couteur, D., Sinclair, D. (2010). A Blueprint for Developing Therapeutic Approaches That Increase Healthspan and Delay Death. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(7), 693-4. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2010). A Pilot Randomized Clinical Trial Utilizing the Drug Burden Index to Reduce Exposure to Anticholinergic and Sedative Medications in Older People. The Annals of Pharmacotherapy, 44(11), 1725-1732. [More Information]
  • Le Couteur, D., Lakatta, E. (2010). A Vascular Theory of Aging. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(10), 1025-7. [More Information]
  • Simon-Santamaria, J., Malovic, I., Warren, A., Oteiza, A., Le Couteur, D., Smedsrod, B., McCourt, P., Sorensen, K. (2010). Age-Related Changes in Scavenger Receptor-Mediated Endocytosis in Rat Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(9), 951-960. [More Information]
  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
  • Le Couteur, D., Ford, G., McLachlan, A. (2010). Evidence, Ethics and Medication Management in Older People. Journal of Pharmacy Practice and Research, 40(2), 148-152.
  • Rochat, S., Cumming, R., Blyth, F., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2010). Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 39(2), 228-233. [More Information]
  • Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2010). Lifestyle factors, medications, and disease influence bone mineral density in older men: findings from the CHAMP study. Osteoporosis International, Online, 1-17. [More Information]
  • Warren, A., Cogger, V., Arias, I., McCuskey, R., Le Couteur, D. (2010). Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice. Microcirculation, 17(1), 32-38. [More Information]
  • Hairi, N., Cumming, R., Naganathan, V., Handelsman, D., Le Couteur, D., Creasey, H., Waite, L., Seibel, M., Sambrook, P. (2010). Loss of Muscle Strength, Mass (Sarcopenia), and Quality (Specific Force) and Its Relationship with Functional Limitation and Physical Disability: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 58(11), 2055-2062. [More Information]
  • Pallardo, F., Lloret, A., Lebel, M., d’Ischia, M., Cogger, V., Le Couteur, D., Gadaleta, M., Castello, G., Pagano, G. (2010). Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. Biogerontology, 11(4), 401-419. [More Information]
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2010). Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. International Journal of Infectious Diseases, 14(10), e857-e867. [More Information]
  • Bleicher, K., Naganathan, V., Cumming, R., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Creasey, H. (2010). Prevalence and treatment of osteoporosis in older Australian men: findings from the CHAMP study. Medical Journal of Australia, 193(7), 387-391. [More Information]
  • Le Couteur, D. (2010). Red yeast rice for dyslipidemia in statin-intolerant patients. Annals of Internal Medicine, 152(2), 134-135. [More Information]
  • Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2010). Socioeconomic status and bone health in community-dwelling older men: the CHAMP Study. Osteoporosis International, 22(5), 1343-1353. [More Information]
  • Le Couteur, D., Blyth, F., Creasey, H., Handelsman, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L., Cumming, R. (2010). The Association of Alanine Transaminase With Aging, Frailty, and Mortality. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(7), 712-717. [More Information]
  • Sabaretnam, T., Kritharides, L., O'Reilly, J., Le Couteur, D. (2010). The effect of aging on the response of isolated hepatocytes to hydrogen peroxide and tert-butyl hydroperoxide. Toxicology in Vitro, 24(1), 123-128. [More Information]
  • O'Reilly, J., Cogger, V., Fraser, R., Le Couteur, D. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. [More Information]
  • Sabaretnam, T., O'Reilly, J., Kritharides, L., Le Couteur, D. (2010). The effect of old age on apolipoprotein E and its receptors in rat liver. Age, 32(1), 69-77. [More Information]
  • Cogger, V., McNerney, G., Nyunt, T., DeLeve, L., McCourt, P., Smedsrod, B., Le Couteur, D., Huser, T. (2010). Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. Journal of Structural Biology, 171(3), 382-388. [More Information]
  • Kwong, P., Cumming, R., Chan, L., Seibel, M., Naganathan, V., Creasey, H., Le Couteur, D., Waite, L., Sambrook, P., Handelsman, D. (2010). Urinary incontinence and quality of life among older community-dwelling Australian men: the CHAMP study. Age and Ageing, 39(3), 349-354. [More Information]
  • Massip, L., Garand, C., Paquet, E., Cogger, V., O'Reilly, J., Tworek, L., Hatherall, A., Taylor, C., Thorin, E., Zahradka, P., Le Couteur, D., et al (2010). Vitamin C restores healthy aging in a mouse model for Werner syndrome. The F A S E B Journal, 24(1), 158-172. [More Information]
  • Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
  • Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009). Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology, 68(1), 97-105. [More Information]
  • Sabaretnam, T., Harris, M., Kockx, M., Witting, P., Le Couteur, D., Kritharides, L. (2009). Effects of hydrogen peroxide and apolipoprotein e isoforms on apolipoprotein e trafficking in HepG2 cells. Clinical and Experimental Pharmacology and Physiology, 36(12), e96-e102. [More Information]
  • Smedsrd, B., Le Couteur, D., Ikejima, K., Kawada, N., Naito, M., Knolle, P., Nagy, L., Senoo, H., Vidal-Vanaclocha, F., Yamaguchi, N., et al (2009). Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium. Liver International, 29(4), 490-501. [More Information]
  • O'Reilly, J., Cogger, V., Le Couteur, D. (2009). Old age is associated with ultrastructural changes in isolated rat liver sinusoidal endothelial cells. Journal of Electron Microscopy, 59(1), 65-69. [More Information]
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2009). Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. Pathology, 41(7), 615-621. [More Information]
  • Le Couteur, D., Everitt, A., Lebel, M. (2009). The aging liver. Geriatrics and Ageing, 12, 319-322.
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2009). Variability in response to medicines in older people: Phenotypic and genotypic factors. Clinical Pharmacology and Therapeutics, 85(4), 431-433. [More Information]
  • Cumming, R., Handelsman, D., Seibel, M., Creasey, H., Sambrook, P., Waite, L., Naganathan, V., Le Couteur, D., Litchfield, M. (2008). Cohort profile: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology, doi:10.1093/ije/dyn071, 1-5. [More Information]
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
  • Iyer, S., Naganathan, V., McLachlan, A., Le Couteur, D. (2008). Medication Withdrawal Trials in People Aged 65 Years and Older: A Systematic Review. Drugs and Aging, 25(12), 1021-1031. [More Information]
  • Le Couteur, D., Warren, A., Cogger, V., Smedsrod, B., Sorensen, K., De Cabo, R., Fraser, R., McCuskey, R. (2008). Old age and the hepatic sinusoid. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 291(6), 672-683. [More Information]
  • Blyth, F., Rochat, S., Cumming, R., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2008). Pain, frailty and comorbidity on older men: The CHAMP study. Pain, 140(1), 224-230. [More Information]
  • Le Couteur, D., Kendig, H. (2008). Pharmaco-epistemology for the prescribing geriatrician. Australasian Journal on Ageing, 27(1), 3-7. [More Information]
  • Cheluvappa, R., Shimmon, R., Dawson, M., Hilmer, S., Le Couteur, D. (2008). Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochimica Polonica, 55(3), 571-580. [More Information]
  • Pearson, K., Baur, J., Lewis, K., Peshkin, L., Price, N., Labinskyy, N., Swindell, W., Kamara, D., Minor, R., et al, Le Couteur, D., Jamieson, H. (2008). Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism, 8(2), 157-168. [More Information]
  • Martinez, I., Nedredal, G., Oie, C., Warren, A., Johansen, O., Le Couteur, D., Smedsrod, B. (2008). The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells. Comparative Hepatology, 7(4), 1-11. [More Information]
  • Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]
  • Le Couteur, D., Cogger, V., McCuskey, R., De Cabo, R., Smedsrod, B., Sorensen, K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. New York Academy of Sciences. Annals, 1114, 79-87. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Hilmer, S., McLachlan, A., Le Couteur, D. (2007). Clinical pharmacology in the geriatric patient. Fundamental and Clinical Pharmacology, 21(3), 217-230. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. New York Academy of Sciences. Annals, 1114, 88-92. [More Information]
  • Everitt, A., Le Couteur, D. (2007). Life Extension by Calorie Restriction in Humans. New York Academy of Sciences. Annals, 1114, 428-433. [More Information]
  • Latimer Hill, E., Cumming, R., Lewis, R., Carrington, S., Le Couteur, D. (2007). Sleep disturbances and falls in older people. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62A(1), 62-66. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]
  • Cheluvappa, R., Jamieson, H., Muller, M., Le Couteur, D. (2007). The effect of Pseudomonas aeruginosa virulence factor, pyocyanin, on the liver sinusoidal endothelial cell. Journal of Gastroenterology and Hepatology, 22(8), 1350-1351. [More Information]
  • Fisher, A., Davis, M., Rubenach, S., Le Couteur, D., McLean, A. (2007). The site-specific epidemiology of hip fracture in the Australian Capital Territory with projections for the first half of the 21st century: Implications for clinical management and health services planning. Australasian Journal on Ageing, 26(1), 45-51.
  • Le Couteur, D., Bailey, L., Naganathan, V. (2006). Beta-blockers and heart failure in older people. European heart journal, 27(7), 887-8; author reply 888-9. [More Information]
  • Everitt, A., Hilmer, S., Brand-Miller, J., Jamieson, H., Truswell, A., Sharma, A., Mason, R., Morris, B., Le Couteur, D. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1(1), 11-31.
  • Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
  • Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
  • Baur, J., Pearson, K., Price, N., Jamieson, H., Lerin, C., Kalra, A., Prabhu, V., Allard, J., Lopez-Lluch, G., Lewis, K., Le Couteur, D., et al (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444(7117), 337-342. [More Information]
  • Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]
  • Cooper, G., Le Couteur, D., Richardson, D., Buckley, N. (2005). A randomized clinical trial of activated charcoal for the routine management of oral drug overdose. QJM, 98(9), 655-660. [More Information]
  • Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
  • Hien, L., Cumming, R., Cameron, I., Chen, J., Lord, S., March, L., Schwarz, J., Le Couteur, D., Sambrook, P. (2005). Atypical antipsychotic medications and risk of falls in residents of aged care facilities. Journal of the American Geriatrics Society, 53(8), 1290-1295. [More Information]
  • Everitt, A., Roth, G., Le Couteur, D., Hilmer, S. (2005). Calorie restriction versus drug therapy to delay the onset of ageing diseases and extend life. Age, 27(1), 39-48. [More Information]
  • Park, G., Katelaris, P., Jones, D., Ngu, M., Le Couteur, D. (2005). Caution before embracing serum markers of liver fibrosis in clinical practice. Gastroenterology, 128(4), 1145-1146. [More Information]
  • Hilmer, S., Shenfield, G., Le Couteur, D. (2005). Clinical Implications of Changes in Hepatic Drug Metabolism in Older People. Therapeutics and Clinical Risk Management, 1(2), 151-156.
  • Graffen, M., Saligari, M., Le Couteur, D., Naganathan, V., McLean, A. (2005). Development of a mentorship programme for rural general practitioners by visiting specialist physicians. Rural and Remote Health, 5(2), 374-374. [More Information]
  • Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
  • Harris, M., Le Couteur, D., Arias, I. (2005). Progressive familial intrahepatic cholestasis: genetic disorders of biliary transporters. Journal of Gastroenterology and Hepatology, 20(6), 807-17. [More Information]
  • Katelaris, P., Jones, B., Lin, B., Le Couteur, D., Ngu, M., Park, G., Seow, F. (2005). The 13C-caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy. Alimentary Pharmacology and Therapeutics, 22(5), 395-403. [More Information]
  • Fisher, A., Davis, M., Le Couteur, D. (2005). The effect of meals at different mealtimes on blood pressure and symptoms in geriatric patients with postprandial hypotension. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 60(2), 184-5; author reply 185-6. [More Information]
  • Fisher, A., Davis, M., McLean, A., Le Couteur, D. (2005). The Epidemiology of falls in semi independent residents in residential care. Australasian Journal on Ageing, 24(2), 98-102.
  • Le Couteur, D., Fraser, R., Hilmer, S., Rivory, L., McLean, A. (2005). The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clinical Pharmacokinetics, 44(2), 187-200. [More Information]
  • Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.
  • McLean, A., Le Couteur, D. (2004). Aging Biology And Geriatric Clinical Pharmacology. Pharmacological Reviews, 56(2), 163-184.
  • Whitbread, A., Mellick, G., Silburn, P., Le Couteur, D., Board, P. (2004). Glutathione Transferase Omega Class Polymorphisms In Parkinson Disease. Neurology, 62(10), 1910-1911.
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., McLean, A., Le Couteur, D. (2004). Preliminary Analysis Of The Sinusoidal Endothelium And Space Of Disse In Ageing Papio Hamadrayas. Comparative Hepatology, 3(Suppl 1), S26-S27.
  • Cumming, R., Glasgow, N., Le Couteur, D., Naganathan, V., Hilmer, S. (2004). Prescribing In Older People. Australian Family Physician, 33(10), 777-781.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • Cogger, V., Muller, M., Fraser, R., McLean, A., Khan, J., Le Couteur, D. (2004). The Effects Of Oxidative Stress On The Liver Sieve. Journal of Hepatology, 41(3), 370-376.
  • Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799.
  • Sullivan, D., Celermajer, D., Le Couteur, D., Lam, C. (2004). The Vascular Implications Of Postprandial Lipoprotein Metabolism. Clinical Biochemist Reviews, 25(1), 19-30.
  • Le Couteur, D., Yin, Z., McLean, A., Rivory, L. (2004). Wash-In Methodology And Modeling To Determine Hepatocellular D-Glucose Transport In The Perfused Rat Liver. Japanese journal of physiology, 54(4), 421-429.
  • Fisher, A., McLean, A., Davis, M., Le Couteur, D. (2003). A multi-center, case control study of the effects of antihypertensive therapy on orthostatic hypotension, postprandial hypotension and falls in octo-and nonagenarians in residential care facilities. Current Therapeutic Research: Clinical and Experimental, 64(3), 206-214.
  • McLean, A., Cogger, V., Chong, G., Warren, A., Markus, A., Dahlstrom, J., Le Couteur, D. (2003). Age-related pseudocapillarization of the human liver. Journal of Pathology, 200(1), 112-117. [More Information]
  • Braet, F., Muller, M., Vekemans, K., Wisse, E., Le Couteur, D. (2003). Antimycin A-induced defenestration in rat hepatic sinusoidal endothelial cells. Hepatology, 38(2), 394-402. [More Information]
  • Cumming, R., Le Couteur, D. (2003). Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs, 17(11), 825-837.
  • Sangalli, M., McLean, A., Peek, M., Rivory, L., Le Couteur, D. (2003). Carbon monoxide disposition and permeability-surface area product in the foetal circulation of the perfused term human placenta. Placenta, 24(1), 8-11.
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., Le Couteur, D., McLean, A. (2003). Hepatic sinusoidal pseudocappilarization with aging in the non-human primate. Experimental Gerontology, 38(10), 1101-1107. [More Information]
  • Le Couteur, D., Fisher, A., Davis, M., McLean, A. (2003). Postprandial systolic blood pressure responses of older people in residential care: association with risk of falling. Gerontology: international journal of experimental, clinical, behavioral, regenerative and technical gerontology, 49(4), 260-264.
  • Park, G., Katelaris, P., Jones, D., Seow, F., Le Couteur, D., Ngu, M. (2003). Validity of the 13C-caffeine breath test as a noninvasive, quantitative test of liver function. Hepatology, 38(5), 1227-1236.
  • Hilmer, S., Naganathan, V., Le Couteur, D. (2003). Why do physicians choose to train in geriatric medicine? Australasian Journal on Ageing, 11(3), 160-162.
  • Croft-Baker, J., Croft-Baker, L., Le Couteur, D., McLean, A. (2002). Age related factors determining safe prescribing for older people. C M E Journal: Geriatric Medicine (CME Geriatric Medicine), 4(1), 4-8.
  • Le Couteur, D., Muller, M., Yang,, M., Mellick, G., McLean, A. (2002). Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease. Reviews on Environmental Health, , 51-64.
  • Yang, M., Mclean, A., Le Couteur, D. (2002). Age-related alteration in hepatic disposition of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and pesticides. Pharmacology and Toxicology, 90(4), 203-207.
  • Andrews, G., Khalil, Z., Le Couteur, D. (2002). Aging research worldwide: Experimental gerontological research in Australia. Experimental Gerontology, 37(12), 1301-1308.
  • Shenfield, G., Le Couteur, D., Rivory, L. (2002). Clinical pharmacology. Medical Journal of Australia, , 9-9.
  • Harvey, P., Gready, J., Yin, Z., Le Couteur, D., Mclean, A. (2002). Hepatic phospholipid changes induced by sustained oxygen supplementation. Pharmacology and Toxicology, 91(3), 150-152.
  • Le Couteur, D., Fraser, R., Cogger, V., McLean, A. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. The Lancet, 359(9317), 1612-1615.
  • Buchanan, D., Silburn, P., Chalk, J., Le Couteur, D., Mellick, G. (2002). The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients. Neuroscience Letters, 327(2), 91-94.
  • Cho, S., McLean, A., Rivory, L., Gatenby, P., Le Couteur, D., Hardman,, D. (2001). Carbon monoxide wash-in method to determine gas transfer in vascular beds: application to rat hindlimb. American Journal of Physiology: Heart and Circulatory Physiology, 280.
  • Cogger, V., Markus, A., Harvey, P., Ansselin, A., McLean, A., Le Couteur, D., Yin,, Z. (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33, 537-543.
  • Cogger, V., Ansselin, A., Le Couteur, D., McLean, A., Mross, P., Hosie, M. (2001). The effect of acute oxidative stress on the ultrastructure of the perfused rat liver. Pharmacology and Toxicology, 89, 306-311.
  • Harvey, P., Gready, J., Yin, Z., Le Couteur, D., McLean, A. (2000). Acute Oxygen Supplementation Restores Markers of Hepatocyte Energy Status and Hypoxia in Cirrhotic Rats. Journal of Pharmacology and Experimental Therapeutics, 293(2), 641-645.
  • Yang, M., McLean, A., Rivory, L., Le Couteur, D. (2000). Hepatic Disposition of Neurotoxins and Pesticides. Pharmacology and Toxicology, 87(6), 286-291.

2014

  • Fransen, M., Su, S., Harmer, A., Blyth, F., Naganathan, V., Sambrook, P., Le Couteur, D., Cumming, R. (2014). A longitudinal study of knee pain in older men: Concord Health and Ageing in Men Project. Age and Ageing, 43(2), 206-212. [More Information]
  • Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
  • Le Couteur, D., Simpson, S., De Cabo, R. (2014). Are glycans the holy grail for biomarkers of aging? (Comment on: Glycans Are a Novel Biomarker of Chronological and Biological Age by Kristic et al.). Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(7), 777-778. [More Information]
  • Hirani, V., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014). Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(3), 417-425. [More Information]
  • Cogger, V., Svistounov, D., Warren, A., Zykova, S., Melvin, R., Solon-Biet, S., O'Reilly, J., McMahon, A., Ballard, J., De Cabo, R., Le Couteur, D., et al (2014). Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(9), 1076-1086. [More Information]
  • Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Longitudinal and Cross-Sectional Relationships of Circulating Reproductive Hormone Levels to Self-Rated Health and Health-Related Quality of Life in Community-Dwelling Older Men. Journal of Clinical Endocrinology and Metabolism, 99(5), 1638-1647. [More Information]
  • Hsu, B., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Longitudinal relationships of circulating reproductive hormone with functional disability, muscle mass and strength in community-dwelling older men; The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 99(9), 3310-3318. [More Information]
  • Hirani, V., Cumming, R., Le Couteur, D., Naganathan, V., Blyth, F., Handelsman, D., Waite, L., Seibel, M. (2014). Low Levels of 25-Hydroxy Vitamin D and Active 1,25-Dihydroxyvitamin D Independently Associated with Type 2 Diabetes Mellitus in Older Australian Men: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(9), 1741-1747. [More Information]
  • Gnjidic, D., Blyth, F., Le Couteur, D., Cumming, R., McLachlan, A., Handelsman, D., Seibel, M., Waite, L., Naganathan, V. (2014). Nonsteroidal anti-inflammatory drugs (NSAIDs) in older people: Prescribing patterns according to pain prevalence and adherence to clinical guidelines. Pain, 155(9), 1814-1820. [More Information]
  • Fairhall, N., Sherrington, C., Cameron, I., Blyth, F., Naganathan, V., Clemson, L., Le Couteur, D., Handelsman, D., Waite, L., Cumming, R. (2014). Predicting participation restriction in community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 43(1), 31-37. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Bell, J. (2014). Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology, 28(1), 10-19. [More Information]
  • Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
  • Le Couteur, D., Wilder, S., De Cabo, R., Simpson, S. (2014). The Evolution of Research on Ageing and Nutrition. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(1), 1-2. [More Information]
  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]
  • Bleicher, K., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014). U-Shaped Association Between Serum 25-Hydroxyvitamin D and Fracture Risk in Older Men: Results from the Prospective Population Based CHAMP Study. Journal of Bone and Mineral Research, 29(9), 2024-2031. [More Information]

2013

  • Cogger, V., Roessner, U., Warren, A., Fraser, R., Le Couteur, D. (2013). A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations. Computational and Structural Biotechnology Journal, 8(11), 1-9. [More Information]
  • Hirani, V., Naganathan, V., Cumming, R., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013). Associations Between Frailty and Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Concentrations in Older Australian Men: The Concord Health and Ageing in Men Project. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 68(9), 1112-1121. [More Information]
  • McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013). Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica, 50(4), 645-649. [More Information]
  • Wilder, S., Le Couteur, D., Simpson, S. (2013). Diet mediates the relationship between longevity and reproduction in mammals. Age, 35(3), 921-927. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2013). Discontinuation of statins in routine care settings. Annals of Internal Medicine, 159(1), 73-74. [More Information]
  • Huang, X., Hancock, D., Gosby, A., McMahon, A., Solon-Biet, S., Le Couteur, D., Conigrave, A., Raubenheimer, D., Simpson, S. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage and heat production in mice. Obesity, 21(1), 85-92. [More Information]
  • Gnjidic, D., Le Couteur, D., Pearson, S., McLachlan, A., Viney, R., Hilmer, S., Blyth, F., Joshy, G., Banks, E. (2013). High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health, 13, 1-9. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2013). Optimal cutoff of polypharmacy and outcomes - reply. Journal of Clinical Epidemiology, 66(4), 465-466. [More Information]
  • Le Couteur, D., Doust, J., Creasey, H., Brayne, C. (2013). Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis. BMJ (International Edition), 347(7925), 1-6. [More Information]
  • Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2013). Predictors of the rate of BMD loss in older men: findings from the CHAMP study. Osteoporosis International, 24(7), 1951-1963. [More Information]
  • Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., et al (2013). Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review, 32(2), 218-222. [More Information]
  • Horan, M., Rumbley, J., Melvin, R., Le Couteur, D., Ballard, J. (2013). Quaternary protein modeling to predict the function of DNA variation found in human mitochondrial cytochrome c oxidase. Journal of Human Genetics, 58(3), 127-134. [More Information]
  • Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013). Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open, 3(3), 1-10. [More Information]
  • Hirani, V., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013). Vitamin D Status Among Older Community Dwelling Men Living In A Sunny Country And Associations With Lifestyle Factors: The Concord Health And Ageing In Men Project, Sydney, Australia. The Journal of Nutrition, Health and Aging, 17(7), 587-593. [More Information]

2012

  • Le Couteur, D., Robinson, M., Leverton, A., Creasey, H., Waite, L., Atkins, K., McLachlan, A. (2012). Adherence, persistence and continuation with cholinesterase inhibitors in Alzheimer's disease. Australasian Journal on Ageing, 31(3), 164-169. [More Information]
  • Le Couteur, D., McLachlan, A., Quinn, R., Simpson, S., De Cabo, R. (2012). Aging biology and novel targets for drug discovery. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 168-174. [More Information]
  • Le Couteur, D., McLachlan, A., De Cabo, R. (2012). Aging, Drugs, and Drug Metabolism. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 137-139. [More Information]
  • Baur, J., Ungvari, Z., Minor, R., Le Couteur, D., De Cabo, R. (2012). Are sirtuins viable targets for improving healthspan and lifespan? Nature Reviews. Drug Discovery, 11(6), 443-461. [More Information]
  • Gnjidic, D., Le Couteur, D., Kouladjian, L., Hilmer, S. (2012). Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clinics in Geriatric Medicine, 28(2), 237-253. [More Information]
  • Le Couteur, D., Handelsman, D. (2012). DNA damage, NF-κB and accelerated aging. Asian Journal of Andrology, 14(6), 811-812. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2012). Drug Burden Index and Beers Criteria: Impact on Functional Outcomes in Older People Living in Self-Care Retirement Villages. The Journal of Clinical Pharmacology, 52(2), 258-265. [More Information]
  • Gnjidic, D., Le Couteur, D., Naganathan, V., Cumming, R., Creasey, H., Waite, L., Sharma, A., Blyth, F., Hilmer, S. (2012). Effects of drug burden index on cognitive function in older men. Journal of Clinical Psychopharmacology, 32(2), 273-277. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology and Therapeutics, 91(3), 521-528. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2012). High-risk prescribing in older people: More harm than good? Aging Health, 8(4), 325-327. [More Information]
  • Bell, S., Le Couteur, D., McLachlan, A., Chen, T., Moles, R., Basger, B., Hilmer, S. (2012). Improving medicine selection for older people: Do we need an Australian classification for inappropriate medicines use? Australian Family Physician, 41(1/2), 9-10. [More Information]
  • Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers.
  • Gnjidic, D., Stanaway, F., Cumming, R., Waite, L., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D. (2012). Mild Cognitive Impairment Predicts Institutionalization among Older Men: A Population-Based Cohort Study. PLoS One, 7(9), 1-8. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2012). Off-Label Use of Medicines: Time for Action. Clinical Pharmacology and Therapeutics, 92(2), 157-157. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012). Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989-995. [More Information]
  • Litchfield, M., Cumming, R., Smith, D., Naganathan, V., Le Couteur, D., Waite, L., Blyth, F., Handelsman, D. (2012). Prostate-specific antigen levels in men aged 70 years and over: Findings from the CHAMP study. Medical Journal of Australia, 196(6), 395-398. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Svistounov, D., Warren, A., McNerney, G., Owen, D., Zencak, D., Zykova, S., Crane, H., Huser, T., Quinn, R., Smedsrod, B., Le Couteur, D., Cogger, V. (2012). The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells. PLoS One, 7(9), 1-9. [More Information]
  • Sorensen, K., McCourt, P., Berg, T., Crossley, C., Le Couteur, D., Wake, K., Smedsrod, B. (2012). The scavenger endothelial cell: a new player in homeostasis and immunity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 303(12), R1217-R1230. [More Information]
  • Hilmer, S., Gnjidic, D., Le Couteur, D. (2012). Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Australian Family Physician, 41(12), 924-928. [More Information]

2011

  • Le Couteur, D., Simpson, S. (2011). Adaptive Senectitude: The Prolongevity Effects of Aging. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(2), 179-182. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • McMahon, A., Hing, A., Cogger, V., Le Couteur, D. (2011). Animal models of early atherosclerosis: How to translate the data into clinical perspectives. In Petru Liuba (Eds.), Silent Vasculopathy in Childhood: Should Clinicians Care, (pp. 39-64). India: Transworld Research Network.
  • Stanaway, F., Blyth, F., Cumming, R., Naganathan, V., Handelsman, D., Waite, L., Sambrook, P., Creasey, H., Seibel, M., Le Couteur, D. (2011). Back pain in older male Italian-born immigrants in Australia: The importance of socioeconomic factors. European Journal of Pain, 15(1), 70-76. [More Information]
  • Travison, T., Nguyen, A., Naganathan, V., Stanaway, F., Blyth, F., Cumming, R., Le Couteur, D., Sambrook, P., Handelsman, D. (2011). Changes in Reproductive Hormone Concentrations Predict the Prevalence and Progression of the Frailty Syndrome in Older Men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 96(8), 2464-2474. [More Information]
  • McLachlan, A., Bath, S., Naganathan, V., Hilmer, S., Le Couteur, D., Gibson, S., Blyth, F. (2011). Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. British Journal of Clinical Pharmacology, 71(3), 351-364. [More Information]
  • Le Couteur, D., Banks, E., Gnjidic, D., McLachlan, A. (2011). Deprescribing. Australian Prescriber, 34(6), 182-185.
  • Le Couteur, D., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Kennerson, M., Naganathan, V., Cumming, R., De Cabo, R. (2011). Determinants of Serum-Induced SIRT1 Expression in Older Men: The CHAMP Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(1), 3-8. [More Information]
  • Stanaway, F., Cumming, R., Naganathan, V., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M., Sambrook, P. (2011). Ethnicity and falls in older men: low rate of falls in Italian-born men in Australia. Age and Ageing, 40, 595-601. [More Information]
  • Le Couteur, D., Cogger, V., Dobbs, B., Fraser, R. (2011). Fenestrations and lipoproteins. Cardiovascular pathology, 20(3), 191-193. [More Information]
  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(40), 16735-16740. [More Information]
  • Stanaway, F., Gnjidic, D., Blyth, F., Le Couteur, D., Naganathan, V., Waite, L., Seibel, M., Handelsman, D., Sambrook, P., Cumming, R. (2011). How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ: British Medical Journal, 343, d7679-1-d7679-4. [More Information]
  • Blyth, F., Cumming, R., Nicholas, M., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2011). Intrusive Pain and Worry about Health in Older Men: The CHAMP Study. Pain, 152(2), 447-452. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2011). Reducing drugs in older adults is more. Archives of Internal Medicine, 171(9), 868-869. [More Information]
  • Labbé, A., Garand, C., Cogger, V., Paquet, E., Desbiens, M., Le Couteur, D., Lebel, M. (2011). Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(312492), 264-278. [More Information]
  • Nabipour, I., Sambrook, P., Blyth, F., Janu, M., Waite, L., Naganathan, V., Handelsman, D., Le Couteur, D., Cumming, R., Seibel, M. (2011). Serum Uric Acid Is Associated With Bone Health in Older Men: A Cross-Sectional Population-Based Study. Journal of Bone and Mineral Research, 26(5), 955-964. [More Information]
  • Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2011). Socioeconomic status and bone health in community-dwelling older men: The CHAMP Study. Osteoporosis International, 22(5), 1343-1353. [More Information]
  • Everitt, A., Le Couteur, D., Kendig, H. (2011). The Changing Face of Ageing Research and Practice in Australia over the last 50 years. Australasian Journal on Ageing, 30(4), 173-174. [More Information]
  • Warren, A., Cogger, V., Fraser, R., DeLeve, L., McCuskey, R., Le Couteur, D. (2011). The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research, 2011 (Article ID 439835), 1-7. [More Information]
  • Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]
  • Bleicher, K., Cumming, R., Naganathan, V., Travison, T., Sambrook, P., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M. (2011). The role of fat and lean mass in bone loss in older men: Findings from the CHAMP study. Bone, 49(6), 1299-1305. [More Information]

2010

  • Le Couteur, D., Sinclair, D. (2010). A Blueprint for Developing Therapeutic Approaches That Increase Healthspan and Delay Death. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(7), 693-4. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2010). A Pilot Randomized Clinical Trial Utilizing the Drug Burden Index to Reduce Exposure to Anticholinergic and Sedative Medications in Older People. The Annals of Pharmacotherapy, 44(11), 1725-1732. [More Information]
  • Le Couteur, D., Lakatta, E. (2010). A Vascular Theory of Aging. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(10), 1025-7. [More Information]
  • Simon-Santamaria, J., Malovic, I., Warren, A., Oteiza, A., Le Couteur, D., Smedsrod, B., McCourt, P., Sorensen, K. (2010). Age-Related Changes in Scavenger Receptor-Mediated Endocytosis in Rat Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(9), 951-960. [More Information]
  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
  • Everitt, A., Heilbronn, L., Morris, B., Brown-Borg, H., Merry, B., Simpson, S., Varady, K., Masoro, E., Redman, L., Le Couteur, D. (2010). Conclusion: Human Calorie Restriction and Anti-Aging Therapy. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 311-318). Dordrecht: Springer.
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2010). Dosing Errors: Age-Related Changes in Pharmacokinetics. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 127-135). New York: Springer Science + Business Media.
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
  • Le Couteur, D., Ford, G., McLachlan, A. (2010). Evidence, Ethics and Medication Management in Older People. Journal of Pharmacy Practice and Research, 40(2), 148-152.
  • Everitt, A., Heilbronn, L., Le Couteur, D. (2010). Food Intake, Life Style, Aging and Human Longevity. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 15-41). Dordrecht: Springer.
  • Everitt, A., Brown-Borg, H., Le Couteur, D., Bartke, A. (2010). Food Restriction, Hormones, Genes and Aging. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 217-318). Dordrecht: Springer.
  • Rochat, S., Cumming, R., Blyth, F., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2010). Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 39(2), 228-233. [More Information]
  • Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2010). Lifestyle factors, medications, and disease influence bone mineral density in older men: findings from the CHAMP study. Osteoporosis International, Online, 1-17. [More Information]
  • Warren, A., Cogger, V., Arias, I., McCuskey, R., Le Couteur, D. (2010). Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice. Microcirculation, 17(1), 32-38. [More Information]
  • Hairi, N., Cumming, R., Naganathan, V., Handelsman, D., Le Couteur, D., Creasey, H., Waite, L., Seibel, M., Sambrook, P. (2010). Loss of Muscle Strength, Mass (Sarcopenia), and Quality (Specific Force) and Its Relationship with Functional Limitation and Physical Disability: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 58(11), 2055-2062. [More Information]
  • Pallardo, F., Lloret, A., Lebel, M., d’Ischia, M., Cogger, V., Le Couteur, D., Gadaleta, M., Castello, G., Pagano, G. (2010). Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. Biogerontology, 11(4), 401-419. [More Information]
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2010). Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. International Journal of Infectious Diseases, 14(10), e857-e867. [More Information]
  • Bleicher, K., Naganathan, V., Cumming, R., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Creasey, H. (2010). Prevalence and treatment of osteoporosis in older Australian men: findings from the CHAMP study. Medical Journal of Australia, 193(7), 387-391. [More Information]
  • Le Couteur, D. (2010). Red yeast rice for dyslipidemia in statin-intolerant patients. Annals of Internal Medicine, 152(2), 134-135. [More Information]
  • Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2010). Socioeconomic status and bone health in community-dwelling older men: the CHAMP Study. Osteoporosis International, 22(5), 1343-1353. [More Information]
  • Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer.
  • Le Couteur, D., Blyth, F., Creasey, H., Handelsman, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L., Cumming, R. (2010). The Association of Alanine Transaminase With Aging, Frailty, and Mortality. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(7), 712-717. [More Information]
  • Sabaretnam, T., Kritharides, L., O'Reilly, J., Le Couteur, D. (2010). The effect of aging on the response of isolated hepatocytes to hydrogen peroxide and tert-butyl hydroperoxide. Toxicology in Vitro, 24(1), 123-128. [More Information]
  • O'Reilly, J., Cogger, V., Fraser, R., Le Couteur, D. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. [More Information]
  • Sabaretnam, T., O'Reilly, J., Kritharides, L., Le Couteur, D. (2010). The effect of old age on apolipoprotein E and its receptors in rat liver. Age, 32(1), 69-77. [More Information]
  • Le Couteur, D., Kendig, H., Naganathan, V., McLachlan, A. (2010). The Ethics of Prescribing Medications to Older People. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 29-42). New York: Springer Science + Business Media.
  • Cogger, V., McNerney, G., Nyunt, T., DeLeve, L., McCourt, P., Smedsrod, B., Le Couteur, D., Huser, T. (2010). Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. Journal of Structural Biology, 171(3), 382-388. [More Information]
  • Kwong, P., Cumming, R., Chan, L., Seibel, M., Naganathan, V., Creasey, H., Le Couteur, D., Waite, L., Sambrook, P., Handelsman, D. (2010). Urinary incontinence and quality of life among older community-dwelling Australian men: the CHAMP study. Age and Ageing, 39(3), 349-354. [More Information]
  • Massip, L., Garand, C., Paquet, E., Cogger, V., O'Reilly, J., Tworek, L., Hatherall, A., Taylor, C., Thorin, E., Zahradka, P., Le Couteur, D., et al (2010). Vitamin C restores healthy aging in a mouse model for Werner syndrome. The F A S E B Journal, 24(1), 158-172. [More Information]

2009

  • Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
  • Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009). Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology, 68(1), 97-105. [More Information]
  • Sabaretnam, T., Harris, M., Kockx, M., Witting, P., Le Couteur, D., Kritharides, L. (2009). Effects of hydrogen peroxide and apolipoprotein e isoforms on apolipoprotein e trafficking in HepG2 cells. Clinical and Experimental Pharmacology and Physiology, 36(12), e96-e102. [More Information]
  • Smedsrd, B., Le Couteur, D., Ikejima, K., Kawada, N., Naito, M., Knolle, P., Nagy, L., Senoo, H., Vidal-Vanaclocha, F., Yamaguchi, N., et al (2009). Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium. Liver International, 29(4), 490-501. [More Information]
  • O'Reilly, J., Cogger, V., Le Couteur, D. (2009). Old age is associated with ultrastructural changes in isolated rat liver sinusoidal endothelial cells. Journal of Electron Microscopy, 59(1), 65-69. [More Information]
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2009). Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. Pathology, 41(7), 615-621. [More Information]
  • Le Couteur, D., Everitt, A., Lebel, M. (2009). The aging liver. Geriatrics and Ageing, 12, 319-322.
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2009). Variability in response to medicines in older people: Phenotypic and genotypic factors. Clinical Pharmacology and Therapeutics, 85(4), 431-433. [More Information]

2008

  • Cumming, R., Handelsman, D., Seibel, M., Creasey, H., Sambrook, P., Waite, L., Naganathan, V., Le Couteur, D., Litchfield, M. (2008). Cohort profile: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology, doi:10.1093/ije/dyn071, 1-5. [More Information]
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
  • Iyer, S., Naganathan, V., McLachlan, A., Le Couteur, D. (2008). Medication Withdrawal Trials in People Aged 65 Years and Older: A Systematic Review. Drugs and Aging, 25(12), 1021-1031. [More Information]
  • Le Couteur, D., Warren, A., Cogger, V., Smedsrod, B., Sorensen, K., De Cabo, R., Fraser, R., McCuskey, R. (2008). Old age and the hepatic sinusoid. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 291(6), 672-683. [More Information]
  • Blyth, F., Rochat, S., Cumming, R., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2008). Pain, frailty and comorbidity on older men: The CHAMP study. Pain, 140(1), 224-230. [More Information]
  • Le Couteur, D., Kendig, H. (2008). Pharmaco-epistemology for the prescribing geriatrician. Australasian Journal on Ageing, 27(1), 3-7. [More Information]
  • Cheluvappa, R., Shimmon, R., Dawson, M., Hilmer, S., Le Couteur, D. (2008). Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochimica Polonica, 55(3), 571-580. [More Information]
  • Pearson, K., Baur, J., Lewis, K., Peshkin, L., Price, N., Labinskyy, N., Swindell, W., Kamara, D., Minor, R., et al, Le Couteur, D., Jamieson, H. (2008). Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism, 8(2), 157-168. [More Information]
  • Martinez, I., Nedredal, G., Oie, C., Warren, A., Johansen, O., Le Couteur, D., Smedsrod, B. (2008). The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells. Comparative Hepatology, 7(4), 1-11. [More Information]
  • Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]

2007

  • Le Couteur, D., Cogger, V., McCuskey, R., De Cabo, R., Smedsrod, B., Sorensen, K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. New York Academy of Sciences. Annals, 1114, 79-87. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Hilmer, S., McLachlan, A., Le Couteur, D. (2007). Clinical pharmacology in the geriatric patient. Fundamental and Clinical Pharmacology, 21(3), 217-230. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. New York Academy of Sciences. Annals, 1114, 88-92. [More Information]
  • Everitt, A., Le Couteur, D. (2007). Life Extension by Calorie Restriction in Humans. New York Academy of Sciences. Annals, 1114, 428-433. [More Information]
  • Latimer Hill, E., Cumming, R., Lewis, R., Carrington, S., Le Couteur, D. (2007). Sleep disturbances and falls in older people. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62A(1), 62-66. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]
  • Cheluvappa, R., Jamieson, H., Muller, M., Le Couteur, D. (2007). The effect of Pseudomonas aeruginosa virulence factor, pyocyanin, on the liver sinusoidal endothelial cell. Journal of Gastroenterology and Hepatology, 22(8), 1350-1351. [More Information]
  • Fisher, A., Davis, M., Rubenach, S., Le Couteur, D., McLean, A. (2007). The site-specific epidemiology of hip fracture in the Australian Capital Territory with projections for the first half of the 21st century: Implications for clinical management and health services planning. Australasian Journal on Ageing, 26(1), 45-51.

2006

  • Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.
  • Le Couteur, D., Bailey, L., Naganathan, V. (2006). Beta-blockers and heart failure in older people. European heart journal, 27(7), 887-8; author reply 888-9. [More Information]
  • Everitt, A., Hilmer, S., Brand-Miller, J., Jamieson, H., Truswell, A., Sharma, A., Mason, R., Morris, B., Le Couteur, D. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1(1), 11-31.
  • Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
  • Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
  • Le Couteur, D., Naganathan, V., Cogger, V., Cumming, R., McLean, A. (2006). Pharmacotherapy in the elderly: clinical issues and perspectives. In Kohli K, Gupta M, Tejwani S. (Eds.), In Contemporary Perspectives on Clinical Pharmacotherapeutics, (pp. 709-722). New Dehli: Elsevier.
  • Baur, J., Pearson, K., Price, N., Jamieson, H., Lerin, C., Kalra, A., Prabhu, V., Allard, J., Lopez-Lluch, G., Lewis, K., Le Couteur, D., et al (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444(7117), 337-342. [More Information]
  • Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]

2005

  • Cooper, G., Le Couteur, D., Richardson, D., Buckley, N. (2005). A randomized clinical trial of activated charcoal for the routine management of oral drug overdose. QJM, 98(9), 655-660. [More Information]
  • Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
  • Hien, L., Cumming, R., Cameron, I., Chen, J., Lord, S., March, L., Schwarz, J., Le Couteur, D., Sambrook, P. (2005). Atypical antipsychotic medications and risk of falls in residents of aged care facilities. Journal of the American Geriatrics Society, 53(8), 1290-1295. [More Information]
  • Everitt, A., Roth, G., Le Couteur, D., Hilmer, S. (2005). Calorie restriction versus drug therapy to delay the onset of ageing diseases and extend life. Age, 27(1), 39-48. [More Information]
  • Park, G., Katelaris, P., Jones, D., Ngu, M., Le Couteur, D. (2005). Caution before embracing serum markers of liver fibrosis in clinical practice. Gastroenterology, 128(4), 1145-1146. [More Information]
  • Hilmer, S., Shenfield, G., Le Couteur, D. (2005). Clinical Implications of Changes in Hepatic Drug Metabolism in Older People. Therapeutics and Clinical Risk Management, 1(2), 151-156.
  • Graffen, M., Saligari, M., Le Couteur, D., Naganathan, V., McLean, A. (2005). Development of a mentorship programme for rural general practitioners by visiting specialist physicians. Rural and Remote Health, 5(2), 374-374. [More Information]
  • Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
  • Harris, M., Le Couteur, D., Arias, I. (2005). Progressive familial intrahepatic cholestasis: genetic disorders of biliary transporters. Journal of Gastroenterology and Hepatology, 20(6), 807-17. [More Information]
  • Katelaris, P., Jones, B., Lin, B., Le Couteur, D., Ngu, M., Park, G., Seow, F. (2005). The 13C-caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy. Alimentary Pharmacology and Therapeutics, 22(5), 395-403. [More Information]
  • Fisher, A., Davis, M., Le Couteur, D. (2005). The effect of meals at different mealtimes on blood pressure and symptoms in geriatric patients with postprandial hypotension. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 60(2), 184-5; author reply 185-6. [More Information]
  • Fisher, A., Davis, M., McLean, A., Le Couteur, D. (2005). The Epidemiology of falls in semi independent residents in residential care. Australasian Journal on Ageing, 24(2), 98-102.
  • Le Couteur, D., Fraser, R., Hilmer, S., Rivory, L., McLean, A. (2005). The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clinical Pharmacokinetics, 44(2), 187-200. [More Information]
  • Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.

2004

  • McLean, A., Le Couteur, D. (2004). Aging Biology And Geriatric Clinical Pharmacology. Pharmacological Reviews, 56(2), 163-184.
  • Whitbread, A., Mellick, G., Silburn, P., Le Couteur, D., Board, P. (2004). Glutathione Transferase Omega Class Polymorphisms In Parkinson Disease. Neurology, 62(10), 1910-1911.
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., McLean, A., Le Couteur, D. (2004). Preliminary Analysis Of The Sinusoidal Endothelium And Space Of Disse In Ageing Papio Hamadrayas. Comparative Hepatology, 3(Suppl 1), S26-S27.
  • Cumming, R., Glasgow, N., Le Couteur, D., Naganathan, V., Hilmer, S. (2004). Prescribing In Older People. Australian Family Physician, 33(10), 777-781.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • Cogger, V., Muller, M., Fraser, R., McLean, A., Khan, J., Le Couteur, D. (2004). The Effects Of Oxidative Stress On The Liver Sieve. Journal of Hepatology, 41(3), 370-376.
  • Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799.
  • Sullivan, D., Celermajer, D., Le Couteur, D., Lam, C. (2004). The Vascular Implications Of Postprandial Lipoprotein Metabolism. Clinical Biochemist Reviews, 25(1), 19-30.
  • Le Couteur, D., Yin, Z., McLean, A., Rivory, L. (2004). Wash-In Methodology And Modeling To Determine Hepatocellular D-Glucose Transport In The Perfused Rat Liver. Japanese journal of physiology, 54(4), 421-429.

2003

  • Fisher, A., McLean, A., Davis, M., Le Couteur, D. (2003). A multi-center, case control study of the effects of antihypertensive therapy on orthostatic hypotension, postprandial hypotension and falls in octo-and nonagenarians in residential care facilities. Current Therapeutic Research: Clinical and Experimental, 64(3), 206-214.
  • McLean, A., Cogger, V., Chong, G., Warren, A., Markus, A., Dahlstrom, J., Le Couteur, D. (2003). Age-related pseudocapillarization of the human liver. Journal of Pathology, 200(1), 112-117. [More Information]
  • Braet, F., Muller, M., Vekemans, K., Wisse, E., Le Couteur, D. (2003). Antimycin A-induced defenestration in rat hepatic sinusoidal endothelial cells. Hepatology, 38(2), 394-402. [More Information]
  • Cumming, R., Le Couteur, D. (2003). Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs, 17(11), 825-837.
  • Sangalli, M., McLean, A., Peek, M., Rivory, L., Le Couteur, D. (2003). Carbon monoxide disposition and permeability-surface area product in the foetal circulation of the perfused term human placenta. Placenta, 24(1), 8-11.
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., Le Couteur, D., McLean, A. (2003). Hepatic sinusoidal pseudocappilarization with aging in the non-human primate. Experimental Gerontology, 38(10), 1101-1107. [More Information]
  • Le Couteur, D., Fisher, A., Davis, M., McLean, A. (2003). Postprandial systolic blood pressure responses of older people in residential care: association with risk of falling. Gerontology: international journal of experimental, clinical, behavioral, regenerative and technical gerontology, 49(4), 260-264.
  • Park, G., Katelaris, P., Jones, D., Seow, F., Le Couteur, D., Ngu, M. (2003). Validity of the 13C-caffeine breath test as a noninvasive, quantitative test of liver function. Hepatology, 38(5), 1227-1236.
  • Hilmer, S., Naganathan, V., Le Couteur, D. (2003). Why do physicians choose to train in geriatric medicine? Australasian Journal on Ageing, 11(3), 160-162.

2002

  • Croft-Baker, J., Croft-Baker, L., Le Couteur, D., McLean, A. (2002). Age related factors determining safe prescribing for older people. C M E Journal: Geriatric Medicine (CME Geriatric Medicine), 4(1), 4-8.
  • Le Couteur, D., Muller, M., Yang,, M., Mellick, G., McLean, A. (2002). Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease. Reviews on Environmental Health, , 51-64.
  • Yang, M., Mclean, A., Le Couteur, D. (2002). Age-related alteration in hepatic disposition of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and pesticides. Pharmacology and Toxicology, 90(4), 203-207.
  • Andrews, G., Khalil, Z., Le Couteur, D. (2002). Aging research worldwide: Experimental gerontological research in Australia. Experimental Gerontology, 37(12), 1301-1308.
  • Shenfield, G., Le Couteur, D., Rivory, L. (2002). Clinical pharmacology. Medical Journal of Australia, , 9-9.
  • Harvey, P., Gready, J., Yin, Z., Le Couteur, D., Mclean, A. (2002). Hepatic phospholipid changes induced by sustained oxygen supplementation. Pharmacology and Toxicology, 91(3), 150-152.
  • Le Couteur, D., Fraser, R., Cogger, V., McLean, A. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. The Lancet, 359(9317), 1612-1615.
  • Buchanan, D., Silburn, P., Chalk, J., Le Couteur, D., Mellick, G. (2002). The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients. Neuroscience Letters, 327(2), 91-94.

2001

  • Cho, S., McLean, A., Rivory, L., Gatenby, P., Le Couteur, D., Hardman,, D. (2001). Carbon monoxide wash-in method to determine gas transfer in vascular beds: application to rat hindlimb. American Journal of Physiology: Heart and Circulatory Physiology, 280.
  • Cogger, V., Markus, A., Harvey, P., Ansselin, A., McLean, A., Le Couteur, D., Yin,, Z. (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33, 537-543.
  • Cogger, V., Ansselin, A., Le Couteur, D., McLean, A., Mross, P., Hosie, M. (2001). The effect of acute oxidative stress on the ultrastructure of the perfused rat liver. Pharmacology and Toxicology, 89, 306-311.

2000

  • Harvey, P., Gready, J., Yin, Z., Le Couteur, D., McLean, A. (2000). Acute Oxygen Supplementation Restores Markers of Hepatocyte Energy Status and Hypoxia in Cirrhotic Rats. Journal of Pharmacology and Experimental Therapeutics, 293(2), 641-645.
  • Yang, M., McLean, A., Rivory, L., Le Couteur, D. (2000). Hepatic Disposition of Neurotoxins and Pesticides. Pharmacology and Toxicology, 87(6), 286-291.

To update your profile click here. For support on your academic profile contact .