Professor David Little

Professor
Paediatrics & Child Health, Children's Hospital, Westmead

Telephone +61 2 9845 3352
Fax +61 2 9687 3180

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Research interests

Dr Little commenced at the University of Sydney based at the Children’s Hospital, Westmead, when it opened in November 1995. In 1998 he began researching the role of bisphosphonates in distraction osteogenesis and in 1999 officially founded Orthopaedic Research and Biotechnology at CHW, which he heads.

In 2005 Dr Little was awarded his PhD on bisphosphonates in distraction osteogenesis. He has initiated further research on osteonecrosis, fracture healing and the interaction of the anabolic and catabolic responses in bone repair. Current focuses include improving bone healing outcomes in neurofibromatosis, and using muscle for in vivo bone tissue engineering. Dr Little remains active clinically and is now working on translating pre-clinical work on bone repair to clinical practice.

International links

Sweden

(Universtiy of Lund) A/Prof Magnus Tagil Combined research projects Exchange visits and presentations Future student exchange

Selected grants

2013

  • Practitioner Fellowship; Little D; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2012

  • Small Rodent Airlaw Caging System; George J, O'Connell P, Cunningham A, Hawthorne W, Little D, Djordjevic J, Harris D, Hebbard L, Liddle C, Fletcher J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Pre-clinical validation of a novel implant for bone tissue engineering; Little D, Cooper-White J, Ruys A, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Novel therapeutic interventions for the orthopaedic complications of Neurofibromatosis type 1 (NF1); Little D, Alexander I, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of muscle and the application of muscle-cell therapies in bone repair; Little D, Schindeler A, Hamrick M; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • In-Vivo Multispectral Imaging FX System: small animal imaging for multi-modal molecular signal localisation in live animals; Marsh D, Baxter R, Ashton A, Howell V, Soon P, Little D, Robinson B; Cancer Institute New South Wales/Equipment Grant.
  • A randomised controlled trial to evaluate the effectiveness of zoledronate therapy in osteonecrosis of the hip; Sambrook P, March L, Buchbinder R, Little D, Buchbinder R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Bisphosphonate Treatment of childhood femoral head avascular necrosis due to Perthes disease; Cowell C, Little D, Munns C, Foster B, Zacharin M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Novel coatings for orthopaedic implants; Grau G, Little D, Zreiqat H, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Novel Scaffolds for repairing bone defects; Zreiqat H, Little D, Dunstan C; Australian Orthopaedic Association Research Foundation Ltd/Research Support.
  • Modelling the loss of NF1 heterozygosity in congenital pseudarthrosis of the tibia (CPT); Little D, Baldock P, Schindeler A, Alexander I; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • The role of muscle cells in bone repair; Little D, Schindeler A; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Role of the Osteoclast in Endochondral Fracture Repair; Little D; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Relationship of the anabolic and catabolic responses in healing a critical sized defect in rats; Little D, Bilston L, Cowell C; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014). A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia, 10, 2250-2258. [More Information]
  • Gray, K., Gibbons, P., Little, D., Burns, J. (2014). Are unilateral and bilateral clubfeet created equal? Analysis of severity and correlation. Journal of Pediatric Orthopaedics. Part B, Article in Press.
  • Gray, K., Burns, J., Little, D., Bellemore, M., Gibbons, P. (2014). Is tibialis anterior tendon transfer effective for recurrent clubfoot? Clinical Orthopaedics and Related Research, 472(2), 750-758. [More Information]
  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014). Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhbmp-2 and anti-resorptive agents. European Cells and Materials, 27, 98-111.
  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]
  • Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Schindeler, A., et al (2013). Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopaedics, 33(3), 269-275. [More Information]
  • Bosemark, P., Isaksson, H., McDonald, M., Little, D., Tägil, M. (2013). Augmentation of autologous bone graft by a combination of bone morphogenic protein and bisphosphonate increased both callus volume and strength. Acta Orthopaedica, 84(1), 106-111. [More Information]
  • Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013). Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials, 26, 120-132. [More Information]
  • Schindeler, A., Kolind, M., Little, D. (2013). Cellular Transitions and Tissue Engineering. Cellular Reprogramming, 15(2), 101-106. [More Information]
  • McDonald, M., Morse, A., Mikulec, K., Peacock, L., Baldock, P., Kostenuik, P., Little, D. (2013). Matrix Metalloproteinase - Driven Endochondral Fracture Union Proceeds Independently of Osteoclast Activity. Journal of Bone and Mineral Research, 28(7), 1550-1560. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013). Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells and Materials, 25, 190-203. [More Information]
  • Sousa, D., McDonald, M., Mikulec, K., Peacock, L., Herzog, H., Lamghari, M., Little, D., Baldock, P. (2013). Neuropeptide Y modulates fracture healing through Y1 receptor signaling. Journal of Orthopaedic Research, 31(10), 1570-1578. [More Information]
  • Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013). Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research, 8(1), 1-9. [More Information]
  • Padhye, B., Dalla-Pozza, L., Little, D., Munns, C. (2013). Use of Zoledronic Acid for Treatment of Chemotherapy Related Osteonecrosis in Children and Adolescents: A Retrospective Analysis. Pediatric Blood and Cancer, 60(9), 1539-1545. [More Information]
  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2012). A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research, 27(1), 68-78. [More Information]
  • Young, M., Little, D., Kim, H. (2012). Evidence for using bisphosphonate to treat Legg-Calve-Perthes disease. Clinical Orthopaedics and Related Research, 470(9), 2462-2475. [More Information]
  • McDonald, M., Morse, A., Mikulec, K., Peacock, L., Yu, N., Baldock, P., Birke, O., Liu, M., Ke, H., Little, D. (2012). Inhibition of Sclerostin by Systemic Treatment with Sclerostin Antibody Enhances Healing of Proximal Tibial Defects in Ovariectomized Rats. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 30(10), 1541-1548. [More Information]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PLoS One, 7(7), 1-17. [More Information]
  • Gray, K., Pacey, V., Gibbons, P., Little, D., Frost, C., Burns, J. (2012). Interventions for congenital talipes equinovarus (clubfoot) (Review). Cochrane Database of Systematic Reviews, 4(2012), 1-27. [More Information]
  • Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012). Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience (Elite Edition), 4E(7), 2647-2653. [More Information]
  • El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011). Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants, 1(3), 13-18.
  • Wilkinson, J., Little, D. (2011). Bisphosphonates in orthopedic applications. Bone, 49(1), 95-102. [More Information]
  • McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2011). Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 29(5), 726-733. [More Information]
  • Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011). Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. Journal of Bone and Joint Surgery: British Volume, 93 B (8), 1134-1139. [More Information]
  • Birke, O., Davies, N., Latimer, M., Little, D., Bellemore, M. (2011). Experience With the Fassier-Duval Telescopic Rod: First 24 Consecutive Cases With a Minimum of 1-Year Follow-up. Journal of Pediatric Orthopaedics, 31(4), 458-464. [More Information]
  • Little, D., Kim, H. (2011). Future Biologic Treatments for Perthes Disease. Orthopedic Clinics of North America, 42(3), 423-427. [More Information]
  • Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011). JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone, 49(6), 1311-1316. [More Information]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
  • Little, D., Kim, H. (2011). Potential for Bisphosphonate Treatment in Legg-Calve-Perthes Disease. Journal of Pediatric Orthopaedics, 31(SUPPL. 2), S182-S188. [More Information]
  • Birke, O., Mitchell, P., Onikul, E., Little, D. (2011). The Effect of Hip Position Upon the Location of the Sciatic Nerve: An MRI Study. Journal of Pediatric Orthopaedics, 31(2), 165-169. [More Information]
  • Sim, P., Johannesen, J., Briody, J., McQuade, M., Hsu, B., Bridge, C., Little, D., Cowell, C., Munns, C. (2011). Zoledronic acid improves bone mineral density, reduces bone turnover and improves skeletal architecture over 2 years of treatment in children with secondary osteoporosis. Bone, 49(5), 939-943. [More Information]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]
  • Ferri-de-Barros, F., Little, D., Bridge, C., Cummine, J., Cree, A. (2010). Atlantoaxial and Craniocervical Arthrodesis in Children: A Tomographic Study Comparing Suitability of C2 Pedicles and C2 Laminae for Screw Fixation. Spine, 35(3), 291-293. [More Information]
  • Yu, N., Schindeler, A., Little, D., Ruys, A. (2010). Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 93B(1), 285-295. [More Information]
  • Goldhahn, J., Little, D., Mitchell, P., Fazzalari, N., Reid, I., Aspenberg, P., Marsh, D., Augat, P., Bavonratanavech, S., Bostrom, M., Dunstan, C., et al (2010). Evidence for anti-osteoporosis therapy in acute fracture situations-Recommendations of a multidisciplinary workshop of the International Society for Fracture Repair. Bone, 46(2), 267-271.
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010). In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells and Materials, 20, 431-442. [More Information]
  • Tagil, M., McDonald, M., Morse, A., Peacock, L., Mikulec, K., Maddock (nee Amanat), N., Godfrey, C., Little, D. (2010). Intermittent PTH(1-34) does not increase union rates in open rat femoral fractures and exhibits attenuated anabolic effects compared to closed fractures. Bone, 46(3), 852-859. [More Information]
  • Gray, K., Pacey, V., Gibbons, P., Little, D., Burns, J. (2010). Interventions for congenital talipes equinovarus (Protocol). Cochrane Database of Systematic Reviews, 7(CD008602), CD008602-1-CD008602-9. [More Information]
  • Kumar, J., Ramachandran, M., Little, D., Zenios, M. (2010). Pelvic osteomyelitis in children. Journal of Pediatric Orthopaedics, 19(1), 38-41. [More Information]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010). Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics, 4(6), 507-517. [More Information]
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
  • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184. [More Information]
  • Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]
  • Kakar, S., Little, D., Einhorn, T. (2009). Can we improve fixation and outcomes in the treatment of femoral neck fractures? The use of pharmaceuticals. Journal of Orthopaedic Trauma, 23(6), 413-421. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Baldock, P., Lee, N., Driessler, F., Lin, S., Allison, S., Stehrer, B., Lin, E., Zhang, L., et al, Little, D. (2009). Neuropeptide Y Knockout Mice Reveal a Central Role of NPY in the Coordination of Bone Mass to Body Weight. PLoS One, 4(12), e8415-1-e8415-9. [More Information]
  • Elefterious, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., et al (2009). Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics. Part A, 149(10), 2327-2338. [More Information]
  • Nguyen, K., Briody, J., McQuade, M., Little, D., Cowell, C., Munns, C. (2009). Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. Bone, 45(5), 898-902. [More Information]
  • Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]
  • Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008). Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 87B(2), 482-491. [More Information]
  • McDonald, M., Dulai, S., Godfrey, C., Maddock (nee Amanat), N., Sztynda, T., Little, D. (2008). Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone, 43(4), 653-662. [More Information]
  • Schindeler, A., McDonald, M., Little, D., Bokka, P. (2008). Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 19(5), 459-466. [More Information]
  • Little, D. (2008). Humanising a Mouse Gene for Human Therapeutics - Lessons From Denosumab. Journal of Bone and Mineral Research, 24, 179-81. [More Information]
  • Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008). Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(1), 65-74. [More Information]
  • Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008). Models of Tibial Fracture Healing in Normal and Nf1-Deficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(8), 1053-1060. [More Information]
  • McDonald, M., Tägil, M., Morse, A., Godfrey, C., Maddock (nee Amanat), N., Little, D. (2008). PTH treatment increases fracture callus size and strength more effectively in closed than open fractures. Bone, 42(Supplement 1), S78-S79. [More Information]
  • Schindeler, A., Little, D. (2008). Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone, 42(4), 616-622. [More Information]
  • Maddock (nee Amanat), N., He, L., Swain, M., Little, D. (2008). The effect of zoledronic acid on the intrinsic material properites of healing bone: An indentation study. Medical Engineering and Physics, 30(7), 843-847. [More Information]
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008). The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology, 149(5), 2403-2410. [More Information]
  • Munns, C., Rajab, M., Hong, J., Briody, J., Hoegler, W., McQuade, M., Little, D., Cowell, C. (2007). Acute phase response and mineral status following low dose intravenous zoledronic acid in children. Bone, 41, 366-370. [More Information]
  • Schindeler, A., Little, D. (2007). Bisphosphonate action: Revelations and deceptions from in vitro studies. Journal of Pharmaceutical Sciences, 96(8), 1872-1878. [More Information]
  • Kiely, P., Ward, K., Bellemore, M., Briody, J., Cowell, C., Little, D. (2007). Bisphosphonate rescue in distraction osteogenesis: a case series. Journal of Pediatric Orthopaedics, 27(4), 467-471. [More Information]
  • Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007). Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of Pediatric Orthopaedics, 27(4), 472-475. [More Information]
  • Zenios, M., Ramachandran, M., Milne, B., Little, D., Smith, N. (2007). Intraoperative stability testing of lateral-entry pin fixation of pediatric supracondylar humeral fractures. Journal of Pediatric Orthopaedics, 27(6), 695-702. [More Information]
  • Ramachandran, M., Ward, K., Brown, R., Munns, C., Cowell, C., Little, D. (2007). Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents. Journal of Bone and Joint Surgery-American Volume, 89(8), 1727-1734. [More Information]
  • Kumar, V., Kumar, D., Howman-Giles, R., Little, D. (2007). Is (99m)Tc-labelled pamidronate a better agent than (99m)Tc-medronate for bone imaging? Nuclear Medicine Communications, 28(2), 101-107. [More Information]
  • Kumar, V., Kumar, D., Howman-Giles, R., Little, D. (2007). Is Tc-99m-labelled pamidronate a better agent than Tc-99m-medronate for bone imaging? Nuclear Medicine Communications, 28(2), 101-107.
  • Baldock, P., Allison, S., Lundberg, P., Lee, N., Slack, K., Lin, E., Enriquez, R., McDonald, M., Zhang, L., During, M., Little, D., et al (2007). Novel role of y1 receptors in the coordinated regulation of bone and energy homeostasis. Journal of Biological Chemistry, 282(26), 19092-19102. [More Information]
  • Maddock (nee Amanat), N., McDonald, M., Godfrey, C., Bilston, L., Little, D. (2007). Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. Journal of Bone and Mineral Research, 22(6), 867-876. [More Information]
  • Zenios, M., Ramachandran, M., Axt, M., Gibbons, P., Peat, J., Little, D. (2007). Posterior sloping angle of the capital femoral physis: interobserver and intraobserver reliability testing and predictor of bilaterality. Journal of Pediatric Orthopaedics, 27(7), 801-804. [More Information]
  • Little, D., Ramachandran, M., Schindeler, A. (2007). The anabolic and catabolic responses in bone repair. Journal of Bone and Joint Surgery: British Volume, 89(4), 425-433. [More Information]
  • Nelson, D., Zenios, M., Ward, K., Ramachandran, M., Little, D. (2007). The deformity index as a predictor of final radiological outcome in Perthes' disease. Journal of Bone and Joint Surgery: British Volume, 89(10), 1369-1374. [More Information]
  • Little, D., Ward, K., Kiely, P., Bellemore, M., Briody, J., Cowell, C. (2006). Bisphosphonate rescue in distraction osteogenesis: A case series. Bone, 38(3, Supplement 1), S80-S80.
  • Bransford, R., Goergens, E., Briody, J., Maddock (nee Amanat), N., Cree, A., Little, D. (2006). Effect of zoledronic acid in an L6-L7 rabbit spine fusion model. European Spine Journal, Online Article, 1-6. [More Information]
  • Kumar, D., Kumar, V., Little, D., Howman-Giles, R., Wong, E., Ali, S. (2006). Evaluation of biodistribution by local versus systemic administration of (99m)Tc-labeled pamidronate. Journal of orthopaedic science, 11(5), 512-520. [More Information]
  • Baldock, P., Allison, S., McDonald, M., Sainsbury, A., Enriquez, R., Little, D., Eisman, J., Gardiner, E., Herzog, H. (2006). Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways. Journal of Bone and Mineral Research, 21(10), 1600-1607. [More Information]
  • Maddock (nee Amanat), N., McDonald, M., Godfrey, C., Bilston, L., Little, D. (2006). Optimal timing of bolus intravenous zoledronic acid in a rat fracture model. Bone, 38, S43-S43.
  • Schindeler, A., Little, D. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? Journal of Bone and Mineral Research, 21(9), 1331-1338. [More Information]
  • Jackson, R., McDonald, M., Nurcombe, V., Little, D., Cool, S. (2006). The use of heparan sulfate to augment fracture repair in a rat fracture model. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 24(4), 636-644. [More Information]
  • Maddock (nee Amanat), N., Brown, R., Bilston, L., Little, D. (2005). A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 23(5), 1029-34. [More Information]
  • Little, D., McDonald, M., Bransford, R., Godfrey, C., Maddock (nee Amanat), N. (2005). Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model. Journal of Bone and Mineral Research, 20(11), 2044-52. [More Information]
  • Schindeler, A., Little, D. (2005). Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochemical and Biophysical Research Communications, 338(2), 710-716. [More Information]
  • Cowell, C., Little, D., Ward, K. (2005). Quantification of metaphyseal modeling in children treated with bisphosphonates. Bone, 36(6), 999-1002. [More Information]
  • Smith, E., Little, D., Briody, J., McEvoy, A., Smith, N., Eisman, J., Gardiner, E. (2005). Transient Disturbance in Physeal Morphology Is Associated With Long-Term Effects of Nitrogen-Containing Bisphosphonates in Growing Rabbits. Journal of Bone and Mineral Research, 20(10), 1731-1741. [More Information]
  • Bobyn, J., Hacking, S., Krygier, J., Harvey, E., Little, D., Tanzer, M. (2005). Zoledronic acid causes enhancement of bone growth into porous implants. Journal of Bone and Joint Surgery: British Volume, 87-B (3), 416-420.
  • Little, D., McDonald, M., Sharpe, I., Peat, R., Williams, P., McEvoy, A. (2005). Zoledronic acid improves femoral head sphericity in a rat model of perthes disease. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 23(4), 862-868. [More Information]
  • McDonald, M., Dulai, S., Godfrey, C., Hamilton, B., Little, D. (2005). Zoledronic acid treatment enhances hard callus formation without delaying endochondral repair in a rat fracture model. Bone, 36(point P377-Mo), S305-S305.
  • Maddock (nee Amanat), N., Brown, R., Bilston, L., Little, D. (2004). A Single Systemic Dose Of Pamidronate Increases Bone Mineral Content And Strength Over Local Pamidronate Administration Or Saline In A Rat Fracture Model. Bone, 34, S46-S47.
  • Chia, J., Holland, A., Little, D., Cass, D. (2004). Pelvic Fractures And Associated Injuries In Children. Journal of Trauma, 56(1), 83-88.
  • Hogler, W., Yap, F., Little, D., Ambler, G., McQuade, M., Cowell, C. (2004). Short-Term Safety Assessment In The Use Of Intravenous Zoledronic Acid In Children. The Journal of Pediatrics, 145(5), 701-704.
  • Smith, E., McEvoy, A., Little, D., Baldock, P., Eisman, J., Gardiner, E. (2004). Transient Retention Of Endochondral Cartilaginous Matrix With Bisphosphonate Treatment In A Long-Term Rabbit Model Of Distraction Osteogenesis. Journal of Bone and Mineral Research, 19(10), 1698-1705.
  • Uglow, M., Peat, R., Hile, M., Bilston, L., Smith, E., Little, D. (2003). Low-Intensity Ultrasound Stimulation in Distraction Osteogenesis in Rabbits. Clinical Orthopaedics and Related Research, 417, 303-312.
  • Little, D., Smith, N., Williams, P., Briody, J., Bilston, L., Smith, E., Gardiner, E., Cowell, C. (2003). Zoledronic acid prevents osteopenia and increases bone strength in a rabbit model of distraction osteogenesis. Journal of Bone and Mineral Research, 18(7), 1300-1307.
  • Little, D., Peat, R., McEvoy, A., Williams, P., Smith, E., Baldock, P. (2003). Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats. Journal of Bone and Mineral Research, 18(11), 2016-2022.
  • Little, D., Bilston, L., Cornell, M., Hile,, M., Briody, J., Cowell, C. (2001). Effect of pamidronate on distraction osteogenesis and fixator-related osteoporosis. Injury, 32.

Conferences

  • Gibbons, P., Little, D., Burns, J., Gray, K. (2012). Biomechanical assessment of children requiring tibialis anterior surgical tendon transfer for residual congenital talipes equinovarus. 3rd Congress of the International Foot and Ankle Biomechanics Community. BioMed Central.
  • Schindeler, A., Ramachandran, M., Little, D. (2006). BMP-2 treatment produces an attenuated response in a mouse model of type 1 neurofibromatosis.
  • Tägil, M., W-Dahl, A., Astrand, J., Little, D., Toksvig-Larsen, S. (2006). Decreasing the catabolic response by a single bisphosphonate infusion shortens the healing time in hemicallotasis operations.
  • McDonald, M., Dulai, S., Godfrey, C., Sztynda, T., Little, D. (2006). Endochondral repair and development proceed normally during zoledronic acid treatment.
  • Schindeler, A., Little, D. (2006). Osteoclasts but not osteoblasts are affected by bispbospbonate bound to a calcified substrate.
  • McDonald, M., Dulai, S., Godfrey, C., Sztynda, T., Little, D. (2006). Single dose zoledronic acid treatment is superior to continuous treatment in enhancing hard callus formation and strength without delayed remodelling. [More Information]
  • Little, D., Bransford, R., McDonald, M., Godfrey, C., Maddock (nee Amanat), N. (2005). Manipulation of the anabolic and catabolic responses in a critical defect model with OP-1 and zoledronic acid. 2nd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, New York: Elsevier Science.

2014

  • Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014). A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia, 10, 2250-2258. [More Information]
  • Gray, K., Gibbons, P., Little, D., Burns, J. (2014). Are unilateral and bilateral clubfeet created equal? Analysis of severity and correlation. Journal of Pediatric Orthopaedics. Part B, Article in Press.
  • Gray, K., Burns, J., Little, D., Bellemore, M., Gibbons, P. (2014). Is tibialis anterior tendon transfer effective for recurrent clubfoot? Clinical Orthopaedics and Related Research, 472(2), 750-758. [More Information]
  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014). Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhbmp-2 and anti-resorptive agents. European Cells and Materials, 27, 98-111.

2013

  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]
  • Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Schindeler, A., et al (2013). Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopaedics, 33(3), 269-275. [More Information]
  • Bosemark, P., Isaksson, H., McDonald, M., Little, D., Tägil, M. (2013). Augmentation of autologous bone graft by a combination of bone morphogenic protein and bisphosphonate increased both callus volume and strength. Acta Orthopaedica, 84(1), 106-111. [More Information]
  • Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013). Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials, 26, 120-132. [More Information]
  • Schindeler, A., Kolind, M., Little, D. (2013). Cellular Transitions and Tissue Engineering. Cellular Reprogramming, 15(2), 101-106. [More Information]
  • McDonald, M., Morse, A., Mikulec, K., Peacock, L., Baldock, P., Kostenuik, P., Little, D. (2013). Matrix Metalloproteinase - Driven Endochondral Fracture Union Proceeds Independently of Osteoclast Activity. Journal of Bone and Mineral Research, 28(7), 1550-1560. [More Information]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013). Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells and Materials, 25, 190-203. [More Information]
  • Sousa, D., McDonald, M., Mikulec, K., Peacock, L., Herzog, H., Lamghari, M., Little, D., Baldock, P. (2013). Neuropeptide Y modulates fracture healing through Y1 receptor signaling. Journal of Orthopaedic Research, 31(10), 1570-1578. [More Information]
  • Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013). Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research, 8(1), 1-9. [More Information]
  • Padhye, B., Dalla-Pozza, L., Little, D., Munns, C. (2013). Use of Zoledronic Acid for Treatment of Chemotherapy Related Osteonecrosis in Children and Adolescents: A Retrospective Analysis. Pediatric Blood and Cancer, 60(9), 1539-1545. [More Information]

2012

  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2012). A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research, 27(1), 68-78. [More Information]
  • Gibbons, P., Little, D., Burns, J., Gray, K. (2012). Biomechanical assessment of children requiring tibialis anterior surgical tendon transfer for residual congenital talipes equinovarus. 3rd Congress of the International Foot and Ankle Biomechanics Community. BioMed Central.
  • Young, M., Little, D., Kim, H. (2012). Evidence for using bisphosphonate to treat Legg-Calve-Perthes disease. Clinical Orthopaedics and Related Research, 470(9), 2462-2475. [More Information]
  • McDonald, M., Morse, A., Mikulec, K., Peacock, L., Yu, N., Baldock, P., Birke, O., Liu, M., Ke, H., Little, D. (2012). Inhibition of Sclerostin by Systemic Treatment with Sclerostin Antibody Enhances Healing of Proximal Tibial Defects in Ovariectomized Rats. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 30(10), 1541-1548. [More Information]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PLoS One, 7(7), 1-17. [More Information]
  • Gray, K., Pacey, V., Gibbons, P., Little, D., Frost, C., Burns, J. (2012). Interventions for congenital talipes equinovarus (clubfoot) (Review). Cochrane Database of Systematic Reviews, 4(2012), 1-27. [More Information]
  • Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012). Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience (Elite Edition), 4E(7), 2647-2653. [More Information]

2011

  • El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011). Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants, 1(3), 13-18.
  • Wilkinson, J., Little, D. (2011). Bisphosphonates in orthopedic applications. Bone, 49(1), 95-102. [More Information]
  • McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2011). Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 29(5), 726-733. [More Information]
  • Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011). Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. Journal of Bone and Joint Surgery: British Volume, 93 B (8), 1134-1139. [More Information]
  • Birke, O., Davies, N., Latimer, M., Little, D., Bellemore, M. (2011). Experience With the Fassier-Duval Telescopic Rod: First 24 Consecutive Cases With a Minimum of 1-Year Follow-up. Journal of Pediatric Orthopaedics, 31(4), 458-464. [More Information]
  • Little, D., Kim, H. (2011). Future Biologic Treatments for Perthes Disease. Orthopedic Clinics of North America, 42(3), 423-427. [More Information]
  • Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011). JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone, 49(6), 1311-1316. [More Information]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
  • Little, D., Kim, H. (2011). Potential for Bisphosphonate Treatment in Legg-Calve-Perthes Disease. Journal of Pediatric Orthopaedics, 31(SUPPL. 2), S182-S188. [More Information]
  • Birke, O., Mitchell, P., Onikul, E., Little, D. (2011). The Effect of Hip Position Upon the Location of the Sciatic Nerve: An MRI Study. Journal of Pediatric Orthopaedics, 31(2), 165-169. [More Information]
  • Sim, P., Johannesen, J., Briody, J., McQuade, M., Hsu, B., Bridge, C., Little, D., Cowell, C., Munns, C. (2011). Zoledronic acid improves bone mineral density, reduces bone turnover and improves skeletal architecture over 2 years of treatment in children with secondary osteoporosis. Bone, 49(5), 939-943. [More Information]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]

2010

  • Ferri-de-Barros, F., Little, D., Bridge, C., Cummine, J., Cree, A. (2010). Atlantoaxial and Craniocervical Arthrodesis in Children: A Tomographic Study Comparing Suitability of C2 Pedicles and C2 Laminae for Screw Fixation. Spine, 35(3), 291-293. [More Information]
  • Yu, N., Schindeler, A., Little, D., Ruys, A. (2010). Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 93B(1), 285-295. [More Information]
  • Goldhahn, J., Little, D., Mitchell, P., Fazzalari, N., Reid, I., Aspenberg, P., Marsh, D., Augat, P., Bavonratanavech, S., Bostrom, M., Dunstan, C., et al (2010). Evidence for anti-osteoporosis therapy in acute fracture situations-Recommendations of a multidisciplinary workshop of the International Society for Fracture Repair. Bone, 46(2), 267-271.
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010). In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells and Materials, 20, 431-442. [More Information]
  • Tagil, M., McDonald, M., Morse, A., Peacock, L., Mikulec, K., Maddock (nee Amanat), N., Godfrey, C., Little, D. (2010). Intermittent PTH(1-34) does not increase union rates in open rat femoral fractures and exhibits attenuated anabolic effects compared to closed fractures. Bone, 46(3), 852-859. [More Information]
  • Gray, K., Pacey, V., Gibbons, P., Little, D., Burns, J. (2010). Interventions for congenital talipes equinovarus (Protocol). Cochrane Database of Systematic Reviews, 7(CD008602), CD008602-1-CD008602-9. [More Information]
  • Kumar, J., Ramachandran, M., Little, D., Zenios, M. (2010). Pelvic osteomyelitis in children. Journal of Pediatric Orthopaedics, 19(1), 38-41. [More Information]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010). Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics, 4(6), 507-517. [More Information]
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
  • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184. [More Information]
  • Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]

2009

  • Kakar, S., Little, D., Einhorn, T. (2009). Can we improve fixation and outcomes in the treatment of femoral neck fractures? The use of pharmaceuticals. Journal of Orthopaedic Trauma, 23(6), 413-421. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Baldock, P., Lee, N., Driessler, F., Lin, S., Allison, S., Stehrer, B., Lin, E., Zhang, L., et al, Little, D. (2009). Neuropeptide Y Knockout Mice Reveal a Central Role of NPY in the Coordination of Bone Mass to Body Weight. PLoS One, 4(12), e8415-1-e8415-9. [More Information]
  • Elefterious, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., et al (2009). Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics. Part A, 149(10), 2327-2338. [More Information]
  • Nguyen, K., Briody, J., McQuade, M., Little, D., Cowell, C., Munns, C. (2009). Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. Bone, 45(5), 898-902. [More Information]
  • Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]

2008

  • Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008). Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 87B(2), 482-491. [More Information]
  • McDonald, M., Dulai, S., Godfrey, C., Maddock (nee Amanat), N., Sztynda, T., Little, D. (2008). Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone, 43(4), 653-662. [More Information]
  • Schindeler, A., McDonald, M., Little, D., Bokka, P. (2008). Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 19(5), 459-466. [More Information]
  • Little, D. (2008). Humanising a Mouse Gene for Human Therapeutics - Lessons From Denosumab. Journal of Bone and Mineral Research, 24, 179-81. [More Information]
  • Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008). Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(1), 65-74. [More Information]
  • Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008). Models of Tibial Fracture Healing in Normal and Nf1-Deficient Mice. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 26(8), 1053-1060. [More Information]
  • McDonald, M., Tägil, M., Morse, A., Godfrey, C., Maddock (nee Amanat), N., Little, D. (2008). PTH treatment increases fracture callus size and strength more effectively in closed than open fractures. Bone, 42(Supplement 1), S78-S79. [More Information]
  • Schindeler, A., Little, D. (2008). Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone, 42(4), 616-622. [More Information]
  • Maddock (nee Amanat), N., He, L., Swain, M., Little, D. (2008). The effect of zoledronic acid on the intrinsic material properites of healing bone: An indentation study. Medical Engineering and Physics, 30(7), 843-847. [More Information]
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008). The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology, 149(5), 2403-2410. [More Information]

2007

  • Munns, C., Rajab, M., Hong, J., Briody, J., Hoegler, W., McQuade, M., Little, D., Cowell, C. (2007). Acute phase response and mineral status following low dose intravenous zoledronic acid in children. Bone, 41, 366-370. [More Information]
  • Schindeler, A., Little, D. (2007). Bisphosphonate action: Revelations and deceptions from in vitro studies. Journal of Pharmaceutical Sciences, 96(8), 1872-1878. [More Information]
  • Kiely, P., Ward, K., Bellemore, M., Briody, J., Cowell, C., Little, D. (2007). Bisphosphonate rescue in distraction osteogenesis: a case series. Journal of Pediatric Orthopaedics, 27(4), 467-471. [More Information]
  • Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007). Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of Pediatric Orthopaedics, 27(4), 472-475. [More Information]
  • Zenios, M., Ramachandran, M., Milne, B., Little, D., Smith, N. (2007). Intraoperative stability testing of lateral-entry pin fixation of pediatric supracondylar humeral fractures. Journal of Pediatric Orthopaedics, 27(6), 695-702. [More Information]
  • Ramachandran, M., Ward, K., Brown, R., Munns, C., Cowell, C., Little, D. (2007). Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents. Journal of Bone and Joint Surgery-American Volume, 89(8), 1727-1734. [More Information]
  • Kumar, V., Kumar, D., Howman-Giles, R., Little, D. (2007). Is (99m)Tc-labelled pamidronate a better agent than (99m)Tc-medronate for bone imaging? Nuclear Medicine Communications, 28(2), 101-107. [More Information]
  • Kumar, V., Kumar, D., Howman-Giles, R., Little, D. (2007). Is Tc-99m-labelled pamidronate a better agent than Tc-99m-medronate for bone imaging? Nuclear Medicine Communications, 28(2), 101-107.
  • Baldock, P., Allison, S., Lundberg, P., Lee, N., Slack, K., Lin, E., Enriquez, R., McDonald, M., Zhang, L., During, M., Little, D., et al (2007). Novel role of y1 receptors in the coordinated regulation of bone and energy homeostasis. Journal of Biological Chemistry, 282(26), 19092-19102. [More Information]
  • Maddock (nee Amanat), N., McDonald, M., Godfrey, C., Bilston, L., Little, D. (2007). Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. Journal of Bone and Mineral Research, 22(6), 867-876. [More Information]
  • Zenios, M., Ramachandran, M., Axt, M., Gibbons, P., Peat, J., Little, D. (2007). Posterior sloping angle of the capital femoral physis: interobserver and intraobserver reliability testing and predictor of bilaterality. Journal of Pediatric Orthopaedics, 27(7), 801-804. [More Information]
  • Little, D., Ramachandran, M., Schindeler, A. (2007). The anabolic and catabolic responses in bone repair. Journal of Bone and Joint Surgery: British Volume, 89(4), 425-433. [More Information]
  • Nelson, D., Zenios, M., Ward, K., Ramachandran, M., Little, D. (2007). The deformity index as a predictor of final radiological outcome in Perthes' disease. Journal of Bone and Joint Surgery: British Volume, 89(10), 1369-1374. [More Information]

2006

  • Little, D., Ward, K., Kiely, P., Bellemore, M., Briody, J., Cowell, C. (2006). Bisphosphonate rescue in distraction osteogenesis: A case series. Bone, 38(3, Supplement 1), S80-S80.
  • Schindeler, A., Ramachandran, M., Little, D. (2006). BMP-2 treatment produces an attenuated response in a mouse model of type 1 neurofibromatosis.
  • Tägil, M., W-Dahl, A., Astrand, J., Little, D., Toksvig-Larsen, S. (2006). Decreasing the catabolic response by a single bisphosphonate infusion shortens the healing time in hemicallotasis operations.
  • Bransford, R., Goergens, E., Briody, J., Maddock (nee Amanat), N., Cree, A., Little, D. (2006). Effect of zoledronic acid in an L6-L7 rabbit spine fusion model. European Spine Journal, Online Article, 1-6. [More Information]
  • McDonald, M., Dulai, S., Godfrey, C., Sztynda, T., Little, D. (2006). Endochondral repair and development proceed normally during zoledronic acid treatment.
  • Kumar, D., Kumar, V., Little, D., Howman-Giles, R., Wong, E., Ali, S. (2006). Evaluation of biodistribution by local versus systemic administration of (99m)Tc-labeled pamidronate. Journal of orthopaedic science, 11(5), 512-520. [More Information]
  • Baldock, P., Allison, S., McDonald, M., Sainsbury, A., Enriquez, R., Little, D., Eisman, J., Gardiner, E., Herzog, H. (2006). Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways. Journal of Bone and Mineral Research, 21(10), 1600-1607. [More Information]
  • Maddock (nee Amanat), N., McDonald, M., Godfrey, C., Bilston, L., Little, D. (2006). Optimal timing of bolus intravenous zoledronic acid in a rat fracture model. Bone, 38, S43-S43.
  • Schindeler, A., Little, D. (2006). Osteoclasts but not osteoblasts are affected by bispbospbonate bound to a calcified substrate.
  • Schindeler, A., Little, D. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? Journal of Bone and Mineral Research, 21(9), 1331-1338. [More Information]
  • McDonald, M., Dulai, S., Godfrey, C., Sztynda, T., Little, D. (2006). Single dose zoledronic acid treatment is superior to continuous treatment in enhancing hard callus formation and strength without delayed remodelling. [More Information]
  • Jackson, R., McDonald, M., Nurcombe, V., Little, D., Cool, S. (2006). The use of heparan sulfate to augment fracture repair in a rat fracture model. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 24(4), 636-644. [More Information]

2005

  • Maddock (nee Amanat), N., Brown, R., Bilston, L., Little, D. (2005). A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 23(5), 1029-34. [More Information]
  • Little, D., Bransford, R., McDonald, M., Godfrey, C., Maddock (nee Amanat), N. (2005). Manipulation of the anabolic and catabolic responses in a critical defect model with OP-1 and zoledronic acid. 2nd Joint Meeting of the European Calcified Tissue Society and the International Bone and Mineral Society, New York: Elsevier Science.
  • Little, D., McDonald, M., Bransford, R., Godfrey, C., Maddock (nee Amanat), N. (2005). Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model. Journal of Bone and Mineral Research, 20(11), 2044-52. [More Information]
  • Schindeler, A., Little, D. (2005). Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochemical and Biophysical Research Communications, 338(2), 710-716. [More Information]
  • Cowell, C., Little, D., Ward, K. (2005). Quantification of metaphyseal modeling in children treated with bisphosphonates. Bone, 36(6), 999-1002. [More Information]
  • Smith, E., Little, D., Briody, J., McEvoy, A., Smith, N., Eisman, J., Gardiner, E. (2005). Transient Disturbance in Physeal Morphology Is Associated With Long-Term Effects of Nitrogen-Containing Bisphosphonates in Growing Rabbits. Journal of Bone and Mineral Research, 20(10), 1731-1741. [More Information]
  • Bobyn, J., Hacking, S., Krygier, J., Harvey, E., Little, D., Tanzer, M. (2005). Zoledronic acid causes enhancement of bone growth into porous implants. Journal of Bone and Joint Surgery: British Volume, 87-B (3), 416-420.
  • Little, D., McDonald, M., Sharpe, I., Peat, R., Williams, P., McEvoy, A. (2005). Zoledronic acid improves femoral head sphericity in a rat model of perthes disease. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 23(4), 862-868. [More Information]
  • McDonald, M., Dulai, S., Godfrey, C., Hamilton, B., Little, D. (2005). Zoledronic acid treatment enhances hard callus formation without delaying endochondral repair in a rat fracture model. Bone, 36(point P377-Mo), S305-S305.

2004

  • Maddock (nee Amanat), N., Brown, R., Bilston, L., Little, D. (2004). A Single Systemic Dose Of Pamidronate Increases Bone Mineral Content And Strength Over Local Pamidronate Administration Or Saline In A Rat Fracture Model. Bone, 34, S46-S47.
  • Chia, J., Holland, A., Little, D., Cass, D. (2004). Pelvic Fractures And Associated Injuries In Children. Journal of Trauma, 56(1), 83-88.
  • Hogler, W., Yap, F., Little, D., Ambler, G., McQuade, M., Cowell, C. (2004). Short-Term Safety Assessment In The Use Of Intravenous Zoledronic Acid In Children. The Journal of Pediatrics, 145(5), 701-704.
  • Smith, E., McEvoy, A., Little, D., Baldock, P., Eisman, J., Gardiner, E. (2004). Transient Retention Of Endochondral Cartilaginous Matrix With Bisphosphonate Treatment In A Long-Term Rabbit Model Of Distraction Osteogenesis. Journal of Bone and Mineral Research, 19(10), 1698-1705.

2003

  • Uglow, M., Peat, R., Hile, M., Bilston, L., Smith, E., Little, D. (2003). Low-Intensity Ultrasound Stimulation in Distraction Osteogenesis in Rabbits. Clinical Orthopaedics and Related Research, 417, 303-312.
  • Little, D., Smith, N., Williams, P., Briody, J., Bilston, L., Smith, E., Gardiner, E., Cowell, C. (2003). Zoledronic acid prevents osteopenia and increases bone strength in a rabbit model of distraction osteogenesis. Journal of Bone and Mineral Research, 18(7), 1300-1307.
  • Little, D., Peat, R., McEvoy, A., Williams, P., Smith, E., Baldock, P. (2003). Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats. Journal of Bone and Mineral Research, 18(11), 2016-2022.

2001

  • Little, D., Bilston, L., Cornell, M., Hile,, M., Briody, J., Cowell, C. (2001). Effect of pamidronate on distraction osteogenesis and fixator-related osteoporosis. Injury, 32.

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