Associate Professor David Wang

Clinical Associate Professor
Woolcock Institute and Royal Prince Alfred Hospital, Central Clinical School

Telephone 9515 5402
Fax 9515 7196

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Biographical details

Dr Wang (PhD, MAppSci, BMed, RPSGT) is a medical graduate from China and obtained his Masters Degree in insomnia research at the Faculty of Health Sciences, RMIT University in 1999. Then he undertook his PhD in Clinical Sleep Medicine at Melbourne University and completed his project before moving to the University of Sydney in 2004. He was awarded a NHMRC Training Fellowship in 2009 and a NHMRC Project Grant as CI-A in 2013. He is a reviewer for NHMRC Project Grant and National Nature Science Foundation of China, and 10 peer-reviewed journals.

Research interests

He has broad interest in sleep and breathing, ventilatory control, hypercapnia and hypoxia, drug effects, and neurocognitive functions. His major research interest is exploring the mechanisms of sleep-disordered breathing, and phenotyping relevant treatment/drug effects using awake ventilatory chemoreflex technique. He is also interested with exploring neuro-cognitive outcomes of sleep-disordered breathing, and relevant hypoxia and hypercapnia mechanisms.

International links

Canada

(Toronto University) Ongoing research collaborations with Prof James Duffin

China

(Tongji University) Set up clinical sleep laboratory at Shanghai Pulmonary Hospital, Tongji University

United Kingdom

(Surrey Sleep Research Centre, University of Surrey) Ongoing collaborations with Prof Derk-Jan Dijk

United States

(Beth Israel Deaconess Medical Center, Harvard Medical School) Ongoing collaborations with Prof Robert Thomas

United States

(University of Wisconsin (Madison)) Ongoing collaborations with Prof Jerry Dempsey

Selected grants

2013

  • Evaluating the effect of morphine on obstructive sleep apnea; Wang D, Eckert D, Somogyi A, Grunstein R, Wong K; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Effect of opioids on breathing during sleep; Wang D; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Journals

  • Wang, D., Thomas, R., Yee, B., Grunstein, R. (2016). Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep disordered breathing. Journal of Applied Physiology, 120(12), 184-186. [More Information]
  • Wang, D., Thomas, R., Yee, B., Grunstein, R. (2016). Last Word on Viewpoint: Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing. Journal of Applied Physiology, 120(12), 1489-1489. [More Information]
  • Vakulin, A., D'Rozario, A., Kim, J., Watson, B., Cross, N., Wang, D., Coeytaux Jackson, A., Bartlett, D., Wong, K., Grunstein, R. (2016). Quantitative sleep EEG and polysomnographic predictors of driving simulator performance in obstructive sleep apnea. Clinical Neurophysiology, 127(2), 1428-1435. [More Information]
  • Nguyen, C., Kim, J., Grunstein, R., Thamrin, C., Wang, D. (2016). Respiratory variability during sleep in methadone maintenance treatment patients. The Journal of Clinical Sleep Medicine, 12(4), 607-616. [More Information]
  • Wang, D., Yee, B., Wong, K., Kim, J., Dijk, D., Duffin, J., Grunstein, R. (2015). Comparing the effect of hypercapnia and hypoxia on the electroencephalogram during wakefulness. Clinical Neurophysiology, 126(1), 103-109. [More Information]
  • Wang, D., Bai, X., Williams, S., Hua, S., Kim, J., Marshall, N., D'Rozario, A., Grunstein, R. (2015). Modafinil Increases Awake EEG Activation and Improves Performance in Obstructive Sleep Apnea During Continuous Positive Airway Pressure Withdrawal. Sleep, 38(8), 1297-1303. [More Information]
  • Wang, D., Lintzeris, N., Leung, S., Haber, P., Yee, B., Grunstein, R. (2015). Reversal of central sleep apnoea with change from methadone to buprenorphine-naloxone: a case report. European Respiratory Journal, 46(4), 1202-1205. [More Information]
  • Wang, D., Yee, B., Rowsell, L. (2015). Sleep-disordered breathing-related neurocognitive impairment, time to think beyond hypoxia and sleep fragmentation? Sleep and Breathing, 19, 23-24. [More Information]
  • Wang, D., Piper, A., Yee, B., Wong, K., Kim, J., D'Rozario, A., Rowsell, L., Dijk, D., Grunstein, R. (2014). Hypercapnia is a Key Correlate of EEG Activation and Daytime Sleepiness in Hypercapnic Sleep Disordered Breathing Patients. The Journal of Clinical Sleep Medicine, 10(5), 517-522. [More Information]
  • Dempsey, J., Xie, A., Patz, D., Wang, D. (2014). Physiology in Medicine: Obstructive sleep apnea pathogenesis and treatment--considerations beyond airway anatomy. Journal of Applied Physiology, 116(1), 3-12. [More Information]
  • Wang, D., Rowsell, L., Yee, B. (2014). Positive airway pressure treatment for opioid-related central sleep apnea, where are we now? Sleep and Breathing, 18(2), 229-231. [More Information]
  • Naqvi, H., Wang, D., Glozier, N., Grunstein, R. (2014). Sleep-disordered breathing and psychiatric disorders. Current Psychiatry Reports, 16(12), 1-11. [More Information]
  • Wang, D., Eckert, D., Grunstein, R. (2013). Drug effects on ventilatory control and upper airway physiology related to sleep apnea. Respiratory Physiology and Neurobiology, 188(3), 257-266. [More Information]
  • Wang, D., Somogyi, A., Yee, B., Wong, K., Kaur, J., Wrigley, P., Grunstein, R. (2013). The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea. Respiratory Physiology and Neurobiology, 185(3), 526-532. [More Information]
  • Killick, R., Wang, D., Hoyos, C., Yee, B., Grunstein, R., Liu, P. (2013). The effects of testosterone on ventilatory responses in men with obstructive sleep apnoea: a randomised, placebo-controlled trial. Journal of Sleep Research, 22(3), 331-336. [More Information]
  • Wang, D., Marshall, N., Duffin, J., Yee, B., Wong, K., Noori, N., Ng, S., Grunstein, R. (2011). Phenotyping interindividual variability in obstructive sleep apnoea response to temazepam using ventilatory chemoreflexes during wakefulness. Journal of Sleep Research, 20(4), 526-532. [More Information]
  • Wang, D., Piper, A., Wong, K., Yee, B., Marshall, N., Dijk, D., Grunstein, R. (2011). Slow Wave Sleep in Patients with Respiratory Failure. Sleep Medicine, 12(4), 378-383. [More Information]
  • Phillips, C., Yee, B., Trenell, M., Magnussen, J., Wang, D., Banerjee, D., Berend, N., Grunstein, R. (2009). Changes in regional adiposity and cardio-metabolic function following a weight loss program with sibutramine in obese men with obstructive sleep apnea. The Journal of Clinical Sleep Medicine, 5(5), 416-421. [More Information]
  • Piper, A., Wang, D., Yee, B., Grunstein, R., Barnes, D. (2008). Randomised trial of CPAP vs bilevel support in the treatment of obesity hypoventilation syndrome without severe nocturnal desaturation. Thorax, 63(5), 395-401. [More Information]
  • Vedam, H., Phillips, C., Wang, D., Barnes, D., Hedner, J., Unger, G., Grunstein, R. (2008). Short-term hypoxia reduces arterial stiffness in healthy men. European Journal of Applied Physiology, 105(1), 19-25. [More Information]
  • Wang, D., Teichtahl, H., Goodman, C., Drummer, O., Grunstein, R., Kronborg, I. (2008). Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: Possible mechanisms. The Journal of Clinical Sleep Medicine, 4(6), 557-562. [More Information]
  • Wang, D., Wong, K., Dungan, G., Buchanan, P., Yee, B., Grunstein, R. (2008). The validity of wrist actimetry assessment of sleep with and without sleep apnea. The Journal of Clinical Sleep Medicine, 4(5), 450-455. [More Information]
  • Wang, D., Teichtahl, H. (2007). Opioids, sleep architecture and sleep-disordered breathing. Sleep Medicine Reviews, 11(1), 35-46. [More Information]
  • Teichtahl, H., Wang, D. (2007). Sleep-disordered breathing with chronic opioid use. Expert Opinion on Drug Safety, 6(6), 641-649. [More Information]
  • Wang, D., Grunstein, R., Teichtahl, H. (2006). Association between ventilatory response to hypercapnia and obstructive sleep apnea-hypopnea index in asymptomatic subjects. Sleep and Breathing, 11(2), 103-108. [More Information]
  • Wang, D., Teichtahl, H., Drummer, O., Goodman, C., Cherry, G., Cunnington, D., Kronborg, I. (2005). Central Sleep Apnea in Stable Methadone Maintenance Treatment Patients. Chest, 128(3), 1348-1356. [More Information]
  • Teichtahl, H., Wang, D., Cunnington, D., Quinnell, T., Tran, H., Kronborg, I., Drummer, O. (2005). Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients. Chest, 128(3), 1339-1347. [More Information]
  • Teichtahl, H., Wang, D., Cunnington, D., Kronborg, H., Goodman, C., Prodromidis, A., Drummer, O. (2004). Cardiorespiratory function in stable methadone maintenance treatment (MMT) patients. Addiction Biology, 9(3-4), 247-253. [More Information]
  • Teichtahl, H., Cunnington, D., Cherry, G., Wang, D. (2003). Scoring polysomnography respiratory events: the utility of nasal pressure and oro-nasal thermal sensor recordings. Sleep Medicine, 4(5), 419-425. [More Information]

2016

  • Wang, D., Thomas, R., Yee, B., Grunstein, R. (2016). Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep disordered breathing. Journal of Applied Physiology, 120(12), 184-186. [More Information]
  • Wang, D., Thomas, R., Yee, B., Grunstein, R. (2016). Last Word on Viewpoint: Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing. Journal of Applied Physiology, 120(12), 1489-1489. [More Information]
  • Vakulin, A., D'Rozario, A., Kim, J., Watson, B., Cross, N., Wang, D., Coeytaux Jackson, A., Bartlett, D., Wong, K., Grunstein, R. (2016). Quantitative sleep EEG and polysomnographic predictors of driving simulator performance in obstructive sleep apnea. Clinical Neurophysiology, 127(2), 1428-1435. [More Information]
  • Nguyen, C., Kim, J., Grunstein, R., Thamrin, C., Wang, D. (2016). Respiratory variability during sleep in methadone maintenance treatment patients. The Journal of Clinical Sleep Medicine, 12(4), 607-616. [More Information]

2015

  • Wang, D., Yee, B., Wong, K., Kim, J., Dijk, D., Duffin, J., Grunstein, R. (2015). Comparing the effect of hypercapnia and hypoxia on the electroencephalogram during wakefulness. Clinical Neurophysiology, 126(1), 103-109. [More Information]
  • Wang, D., Bai, X., Williams, S., Hua, S., Kim, J., Marshall, N., D'Rozario, A., Grunstein, R. (2015). Modafinil Increases Awake EEG Activation and Improves Performance in Obstructive Sleep Apnea During Continuous Positive Airway Pressure Withdrawal. Sleep, 38(8), 1297-1303. [More Information]
  • Wang, D., Lintzeris, N., Leung, S., Haber, P., Yee, B., Grunstein, R. (2015). Reversal of central sleep apnoea with change from methadone to buprenorphine-naloxone: a case report. European Respiratory Journal, 46(4), 1202-1205. [More Information]
  • Wang, D., Yee, B., Rowsell, L. (2015). Sleep-disordered breathing-related neurocognitive impairment, time to think beyond hypoxia and sleep fragmentation? Sleep and Breathing, 19, 23-24. [More Information]

2014

  • Wang, D., Piper, A., Yee, B., Wong, K., Kim, J., D'Rozario, A., Rowsell, L., Dijk, D., Grunstein, R. (2014). Hypercapnia is a Key Correlate of EEG Activation and Daytime Sleepiness in Hypercapnic Sleep Disordered Breathing Patients. The Journal of Clinical Sleep Medicine, 10(5), 517-522. [More Information]
  • Dempsey, J., Xie, A., Patz, D., Wang, D. (2014). Physiology in Medicine: Obstructive sleep apnea pathogenesis and treatment--considerations beyond airway anatomy. Journal of Applied Physiology, 116(1), 3-12. [More Information]
  • Wang, D., Rowsell, L., Yee, B. (2014). Positive airway pressure treatment for opioid-related central sleep apnea, where are we now? Sleep and Breathing, 18(2), 229-231. [More Information]
  • Naqvi, H., Wang, D., Glozier, N., Grunstein, R. (2014). Sleep-disordered breathing and psychiatric disorders. Current Psychiatry Reports, 16(12), 1-11. [More Information]

2013

  • Wang, D., Eckert, D., Grunstein, R. (2013). Drug effects on ventilatory control and upper airway physiology related to sleep apnea. Respiratory Physiology and Neurobiology, 188(3), 257-266. [More Information]
  • Wang, D., Somogyi, A., Yee, B., Wong, K., Kaur, J., Wrigley, P., Grunstein, R. (2013). The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea. Respiratory Physiology and Neurobiology, 185(3), 526-532. [More Information]
  • Killick, R., Wang, D., Hoyos, C., Yee, B., Grunstein, R., Liu, P. (2013). The effects of testosterone on ventilatory responses in men with obstructive sleep apnoea: a randomised, placebo-controlled trial. Journal of Sleep Research, 22(3), 331-336. [More Information]

2011

  • Wang, D., Marshall, N., Duffin, J., Yee, B., Wong, K., Noori, N., Ng, S., Grunstein, R. (2011). Phenotyping interindividual variability in obstructive sleep apnoea response to temazepam using ventilatory chemoreflexes during wakefulness. Journal of Sleep Research, 20(4), 526-532. [More Information]
  • Wang, D., Piper, A., Wong, K., Yee, B., Marshall, N., Dijk, D., Grunstein, R. (2011). Slow Wave Sleep in Patients with Respiratory Failure. Sleep Medicine, 12(4), 378-383. [More Information]

2009

  • Phillips, C., Yee, B., Trenell, M., Magnussen, J., Wang, D., Banerjee, D., Berend, N., Grunstein, R. (2009). Changes in regional adiposity and cardio-metabolic function following a weight loss program with sibutramine in obese men with obstructive sleep apnea. The Journal of Clinical Sleep Medicine, 5(5), 416-421. [More Information]

2008

  • Piper, A., Wang, D., Yee, B., Grunstein, R., Barnes, D. (2008). Randomised trial of CPAP vs bilevel support in the treatment of obesity hypoventilation syndrome without severe nocturnal desaturation. Thorax, 63(5), 395-401. [More Information]
  • Vedam, H., Phillips, C., Wang, D., Barnes, D., Hedner, J., Unger, G., Grunstein, R. (2008). Short-term hypoxia reduces arterial stiffness in healthy men. European Journal of Applied Physiology, 105(1), 19-25. [More Information]
  • Wang, D., Teichtahl, H., Goodman, C., Drummer, O., Grunstein, R., Kronborg, I. (2008). Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: Possible mechanisms. The Journal of Clinical Sleep Medicine, 4(6), 557-562. [More Information]
  • Wang, D., Wong, K., Dungan, G., Buchanan, P., Yee, B., Grunstein, R. (2008). The validity of wrist actimetry assessment of sleep with and without sleep apnea. The Journal of Clinical Sleep Medicine, 4(5), 450-455. [More Information]

2007

  • Wang, D., Teichtahl, H. (2007). Opioids, sleep architecture and sleep-disordered breathing. Sleep Medicine Reviews, 11(1), 35-46. [More Information]
  • Teichtahl, H., Wang, D. (2007). Sleep-disordered breathing with chronic opioid use. Expert Opinion on Drug Safety, 6(6), 641-649. [More Information]

2006

  • Wang, D., Grunstein, R., Teichtahl, H. (2006). Association between ventilatory response to hypercapnia and obstructive sleep apnea-hypopnea index in asymptomatic subjects. Sleep and Breathing, 11(2), 103-108. [More Information]

2005

  • Wang, D., Teichtahl, H., Drummer, O., Goodman, C., Cherry, G., Cunnington, D., Kronborg, I. (2005). Central Sleep Apnea in Stable Methadone Maintenance Treatment Patients. Chest, 128(3), 1348-1356. [More Information]
  • Teichtahl, H., Wang, D., Cunnington, D., Quinnell, T., Tran, H., Kronborg, I., Drummer, O. (2005). Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients. Chest, 128(3), 1339-1347. [More Information]

2004

  • Teichtahl, H., Wang, D., Cunnington, D., Kronborg, H., Goodman, C., Prodromidis, A., Drummer, O. (2004). Cardiorespiratory function in stable methadone maintenance treatment (MMT) patients. Addiction Biology, 9(3-4), 247-253. [More Information]

2003

  • Teichtahl, H., Cunnington, D., Cherry, G., Wang, D. (2003). Scoring polysomnography respiratory events: the utility of nasal pressure and oro-nasal thermal sensor recordings. Sleep Medicine, 4(5), 419-425. [More Information]

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